Member Publications
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141 Member Publications for August 2016
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Frealign: An Exploratory Tool for Single-Particle Cryo-EM.
- Meth. Enzymol. - published August 31, 2016
- Grigorieff N
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Cryo-EM Structure Determination Using Segmented Helical Image Reconstruction.
- Meth. Enzymol. - published August 31, 2016
- Fromm SA, Sachse C
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High-Resolution Macromolecular Structure Determination by MicroED, a cryo-EM Method.
- Meth. Enzymol. - published August 31, 2016
- Rodriguez JA, Gonen T
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Cryo-Electron Tomography and Subtomogram Averaging.
- Meth. Enzymol. - published August 31, 2016
- Wan W, Briggs JA
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Structural basis of kainate subtype glutamate receptor desensitization.
- Nature - published August 31, 2016
- Meyerson JR, Chittori S, Merk A, Rao P, Han TH, Serpe M, Mayer ML, Subramaniam S
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Structure of an N276-dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole adjacent to the CD4 Binding Site.
- J. Virol. - published August 31, 2016
- Wibmer CK, Gorman J, Anthony CS, Mkhize NN, Druz A, York T, Schmidt SD, Labuschagne P, Louder MK, Bailer RT, Abdool Karim SS, Mascola JR, Williamson C, Moore PL, Kwong PD, Morris L
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Packaging and prefusion stabilization separately and additively increase the quantity and quality of RSV-neutralizing antibodies induced by respiratory syncytial virus (RSV) fusion protein expressed by a parainfluenza vector.
- J. Virol. - published August 31, 2016
- Liang B, Ngwuta JO, Herbert R, Swerczek J, Dorward DW, Amaro-Carambot E, Mackow N, Kabatova B, Lingemann M, Surman S, Yang L, Chen M, Moin SM, Kumar A, McLellan JS, Kwong PD, Graham BS, Schaap-Nutt A, Collins PL, Munir S
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Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.
- EBioMedicine - published August 31, 2016
- Bradley T, Trama A, Tumba N, Gray E, Lu X, Madani N, Jahanbakhsh F, Eaton A, Xia SM, Parks R, Lloyd KE, Sutherland LL, Scearce RM, Bowman CM, Barnett S, Abdool-Karim SS, Boyd SD, Melillo B, Smith AB, Sodroski J, Kepler TB, Alam SM, Gao F, Bonsignori M, Liao HX, Moody MA, Montefiori D, Santra S, Morris L, Haynes BF
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Crystal Structures of Quinolinate Synthase in Complex with a Substrate Analogue, the Condensation Intermediate, and Substrate-Derived Product.
- J. Am. Chem. Soc. - published August 30, 2016
- Volbeda A, Darnault C, Renoux O, Reichmann D, Amara P, Ollagnier de Choudens S, Fontecilla-Camps JC
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Documentation of an Imperative To Improve Methods for Predicting Membrane Protein Stability.
- Biochemistry - published August 30, 2016
- Kroncke BM, Duran AM, Mendenhall JL, Meiler J, Blume JD, Sanders CR
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Staphylococcal SCCmec elements encode an active MCM-like helicase and thus may be replicative.
- Nat. Struct. Mol. Biol. - published August 29, 2016
- Mir-Sanchis I, Roman CA, Misiura A, Pigli YZ, Boyle-Vavra S, Rice PA
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Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses.
- J. Mol. Biol. - published August 28, 2016
- Chatterjee S, Basler CF, Amarasinghe GK, Leung DW
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Dimerization Controls Marburg Virus VP24-dependent Modulation of Host Antioxidative Stress Responses.
- J. Mol. Biol. - published August 28, 2016
- Johnson B, Li J, Adhikari J, Edwards MR, Zhang H, Schwarz T, Leung DW, Basler CF, Gross ML, Amarasinghe GK
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Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection.
- Nat Commun - published August 27, 2016
- Ferretti LP, Himmels SF, Trenner A, Walker C, von Aesch C, Eggenschwiler A, Murina O, Enchev RI, Peter M, Freire R, Porro A, Sartori AA
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Asymmetric cryo-EM reconstruction of phage MS2 reveals genome structure in situ.
- Nat Commun - published August 27, 2016
- Koning RI, Gomez-Blanco J, Akopjana I, Vargas J, Kazaks A, Tars K, Carazo JM, Koster AJ
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The future of NMR-based metabolomics.
- Curr. Opin. Biotechnol. - published August 27, 2016
- Markley JL, Brüschweiler R, Edison AS, Eghbalnia HR, Powers R, Raftery D, Wishart DS
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Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
- PLoS Pathog. - published August 26, 2016
- Jardine JG, Sok D, Julien JP, Briney B, Sarkar A, Liang CH, Scherer EA, Henry Dunand CJ, Adachi Y, Diwanji D, Hsueh J, Jones M, Kalyuzhniy O, Kubitz M, Spencer S, Pauthner M, Saye-Francisco KL, Sesterhenn F, Wilson PC, Galloway DM, Stanfield RL, Wilson IA, Burton DR, Schief WR
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Structure of the STRA6 receptor for retinol uptake.
- Science - published August 26, 2016
- Chen Y, Clarke OB, Kim J, Stowe S, Kim YK, Assur Z, Cavalier M, Godoy-Ruiz R, von Alpen DC, Manzini C, Blaner WS, Frank J, Quadro L, Weber DJ, Shapiro L, Hendrickson WA, Mancia F
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Seipin is required for converting nascent to mature lipid droplets.
- Elife - published August 26, 2016
- Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV
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Evoking picomolar binding in RNA by a single phosphorodithioate linkage.
- Nucleic Acids Res. - published August 26, 2016
- Abeydeera ND, Egli M, Cox N, Mercier K, Conde JN, Pallan PS, Mizurini DM, Sierant M, Hibti FE, Hassell T, Wang T, Liu FW, Liu HM, Martinez C, Sood AK, Lybrand TP, Frydman C, Monteiro RQ, Gomer RH, Nawrot B, Yang X
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TRPA1 and TRPV1 contribute to iodine antiseptics-associated pain and allergy.
- EMBO Rep. - published August 26, 2016
- Su D, Zhao H, Hu J, Tang D, Cui J, Zhou M, Yang J, Wang S
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Targeted Disruption of the Interaction Between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
- J. Biol. Chem. - published August 25, 2016
- Alicea-Velázquez NL, Shinsky SA, Loh DM, Lee JH, Skalnik DG, Cosgrove MS
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Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
- Nature - published August 24, 2016
- Tang L, Gamal El-Din TM, Swanson TM, Pryde DC, Scheuer T, Zheng N, Catterall WA
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Mechanism of Error-Free Bypass of the Environmental Carcinogen N-(2-Deoxyguanosin-8-yl)-3-aminobenzanthrone Adduct by Human DNA Polymerase.
- Chembiochem - published August 24, 2016
- Patra A, Politica DA, Chatterjee A, Tokarsky EJ, Suo Z, Basu AK, Stone MP, Egli M
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High-resolution crystal structures of Colocasia esculenta tarin lectin.
- Glycobiology - published August 24, 2016
- Pereira PR, Meagher JL, Winter HC, Goldstein IJ, Paschoalin VM, Silva JT, Stuckey JA
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Crystallographic snapshots of sulfur insertion by lipoyl synthase.
- Proc. Natl. Acad. Sci. U.S.A. - published August 23, 2016
- McLaughlin MI, Lanz ND, Goldman PJ, Lee KH, Booker SJ, Drennan CL
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A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins.
- Elife - published August 23, 2016
- Sung MK, Porras-Yakushi TR, Reitsma JM, Huber FM, Sweredoski MJ, Hoelz A, Hess S, Deshaies RJ
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Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι.
- J. Biol. Chem. - published August 23, 2016
- Choi JY, Patra A, Yeom M, Lee YS, Zhang Q, Egli M, Guengerich FP
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Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices.
- Nat. Chem. Biol. - published August 22, 2016
- Bird GH, Mazzola E, Opoku-Nsiah K, Lammert MA, Godes M, Neuberg DS, Walensky LD
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A Small-Molecule Inhibitor of Lin28.
- ACS Chem. Biol. - published August 22, 2016
- Roos M, Pradère U, Ngondo RP, Behera A, Allegrini S, Civenni G, Zagalak JA, Marchand JR, Menzi M, Towbin H, Scheuermann J, Neri D, Caflisch A, Catapano CV, Ciaudo C, Hall J
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TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats.
- Proc. Natl. Acad. Sci. U.S.A. - published August 22, 2016
- Ma W, Goldberg J
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Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.
- Proc. Natl. Acad. Sci. U.S.A. - published August 22, 2016
- Li X, Saha P, Li J, Blobel G, Pfeffer SR
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Changes in active site histidine hydrogen bonding trigger cryptochrome activation.
- Proc. Natl. Acad. Sci. U.S.A. - published August 22, 2016
- Ganguly A, Manahan CC, Top D, Yee EF, Lin C, Young MW, Thiel W, Crane BR
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Liquid-liquid phase separation in cellular signaling systems.
- Curr. Opin. Struct. Biol. - published August 20, 2016
- Chong PA, Forman-Kay JD
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RSV N-nanorings fused to palivizumab-targeted neutralizing epitope as a nanoparticle RSV vaccine.
- Nanomedicine - published August 20, 2016
- Hervé PL, Deloizy C, Descamps D, Rameix-Welti MA, Fix J, McLellan JS, Eléouët JF, Riffault S
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Immunogenic cross-talk between dengue and Zika viruses.
- Nat. Immunol. - published August 19, 2016
- Harrison SC
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Mechanistic Basis of Glutaminase Activation: A Key Enzyme that Promotes Glutamine Metabolism in Cancer Cells.
- J. Biol. Chem. - published August 19, 2016
- Li Y, Erickson JW, Stalnecker CA, Katt WP, Huang Q, Cerione RA, Ramachandran S
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Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.
- Mol. Cell - published August 18, 2016
- Stefely JA, Licitra F, Laredj L, Reidenbach AG, Kemmerer ZA, Grangeray A, Jaeg-Ehret T, Minogue CE, Ulbrich A, Hutchins PD, Wilkerson EM, Ruan Z, Aydin D, Hebert AS, Guo X, Freiberger EC, Reutenauer L, Jochem A, Chergova M, Johnson IE, Lohman DC, Rush MJ, Kwiecien NW, Singh PK, Schlagowski AI, Floyd BJ, Forsman U, Sindelar PJ, Westphall MS, Pierrel F, Zoll J, Dal Peraro M, Kannan N, Bingman CA, Coon JJ, Isope P, Puccio H, Pagliarini DJ
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Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High-Diversity Transposon Libraries.
- MBio - published August 18, 2016
- Rajagopal M, Martin MJ, Santiago M, Lee W, Kos VN, Meredith T, Gilmore MS, Walker S
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Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing and interaction with the LDL receptor.
- Protein Sci. - published August 18, 2016
- Garvie CW, Fraley CV, Elowe NH, Culyba EK, Lemke CT, Hubbard BK, Kaushik VK, Daniels DS
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Discovery of a proteinaceous cellular receptor for a norovirus.
- Science - published August 18, 2016
- Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW
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Chemical Biology Interrogates Protein Arginine Phosphorylation.
- Cell Chem Biol - published August 18, 2016
- Suskiewicz MJ, Clausen T
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Constraints on the Radical Cation Center of Cytochrome c Peroxidase for Electron Transfer from Cytochrome c.
- Biochemistry - published August 17, 2016
- Payne TM, Yee EF, Dzikovski B, Crane BR
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Towards a structural blueprint for bilayer-mediated channel mechanosensitivity.
- Channels (Austin) - published August 17, 2016
- Bavi N, Cox CD, Perozo E, Martinac B
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Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy.
- Mol. Biol. Cell - published August 17, 2016
- Aguet F, Upadhyayula S, Gaudin R, Chou YY, Cocucci E, He K, Chen BC, Mosaliganti K, Pasham M, Skillern W, Legant WR, Liu TL, Findlay G, Marino E, Danuser G, Megason S, Betzig E, Kirchhausen T
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Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.
- Cancer Discov - published August 17, 2016
- Kühn MW, Song E, Feng Z, Sinha A, Chen CW, Deshpande AJ, Cusan M, Farnoud N, Mupo A, Grove C, Koche R, Bradner JE, de Stanchina E, Vassiliou GS, Hoshii T, Armstrong SA
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Protocols for Molecular Modeling with Rosetta3 and RosettaScripts.
- Biochemistry - published August 16, 2016
- Bender BJ, Cisneros A, Duran AM, Finn JA, Fu D, Lokits AD, Mueller BK, Sangha AK, Sauer MF, Sevy AM, Sliwoski G, Sheehan JH, DiMaio F, Meiler J, Moretti R
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Myosin light chain kinase steady-state kinetics: comparison of smooth muscle myosin II and nonmuscle myosin IIB as substrates.
- Cell Biochem. Funct. - published August 16, 2016
- Alcala DB, Haldeman BD, Brizendine RK, Krenc AK, Baker JE, Rock RS, Cremo CR
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Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage.
- Nucleic Acids Res. - published August 16, 2016
- Steffen JD, McCauley MM, Pascal JM
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Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anti-cancer agent.
- Blood - published August 16, 2016
- Xiang M, Kim H, Ho VT, Walker SR, Bar-Natan M, Anahtar M, Liu S, Toniolo PA, Kroll Y, Jones N, Giaccone ZT, Heppler LN, Ye DQ, Marineau JJ, Shaw D, Bradner JE, Blonquist T, Neuberg D, Hetz C, Stone RM, Soiffer RJ, Frank DA
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Accelerating the discovery of antibacterial compounds using pathway-directed whole cell screening.
- Bioorg. Med. Chem. - published August 16, 2016
- Matano LM, Morris HG, Wood BM, Meredith TC, Walker S
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In vitro evolution of coenzyme-independent variants from the glmS ribozyme structural scaffold.
- Methods - published August 15, 2016
- Lau MW, Ferré-D'Amaré AR
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Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens.
- J. Virol. - published August 15, 2016
- Sexton NR, Smith EC, Blanc H, Vignuzzi M, Peersen OB, Denison MR
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An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation.
- Nat. Struct. Mol. Biol. - published August 15, 2016
- Imai S, Kumar P, Hellen CU, D'Souza VM, Wagner G
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SEDS proteins are a widespread family of bacterial cell wall polymerases.
- Nature - published August 15, 2016
- Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ
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Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.
- Proc. Natl. Acad. Sci. U.S.A. - published August 15, 2016
- Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ
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Crystal structure of an Fe-S cluster-containing fumarate hydratase enzyme from Leishmania major reveals a unique protein fold.
- Proc. Natl. Acad. Sci. U.S.A. - published August 15, 2016
- Feliciano PR, Drennan CL, Nonato MC
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Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin.
- Proc. Natl. Acad. Sci. U.S.A. - published August 15, 2016
- Li S, Yen L, Pastor WA, Johnston JB, Du J, Shew CJ, Liu W, Ho J, Stender B, Clark AT, Burlingame AL, Daxinger L, Patel DJ, Jacobsen SE
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Recognition elements in the histone H3 and H4 tails for seven different Importins.
- J. Biol. Chem. - published August 15, 2016
- Soniat M, Cağatay T, Chook YM
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Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.
- Circ Arrhythm Electrophysiol - published August 13, 2016
- Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC
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Analytical optimization of active bandwidth and quality factor for TOCSY experiments in NMR spectroscopy.
- J. Biomol. NMR - published August 13, 2016
- Coote P, Bermel W, Wagner G, Arthanari H
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3D implementation of the symbol nomenclature for graphical representation of glycans.
- Glycobiology - published August 13, 2016
- Thieker DF, Hadden JA, Schulten K, Woods RJ
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Crystal structure of Clostridium difficile toxin A.
- Nat Microbiol - published August 12, 2016
- Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB
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Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism.
- Science - published August 12, 2016
- Whicher JR, MacKinnon R
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STRUCTURAL BIOLOGY. Twists and turns in gating ion channels with voltage.
- Science - published August 12, 2016
- Toombes GE, Swartz KJ
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Structural Basis of Zika Virus-Specific Antibody Protection.
- Cell - published August 11, 2016
- Zhao H, Fernandez E, Dowd KA, Speer SD, Platt DJ, Gorman MJ, Govero J, Nelson CA, Pierson TC, Diamond MS, Fremont DH
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GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.
- Cell - published August 11, 2016
- Thomsen AR, Plouffe B, Cahill TJ, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ
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Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases.
- PLoS One - published August 11, 2016
- Verma A, Basile AO, Bradford Y, Kuivaniemi H, Tromp G, Carey D, Gerhard GS, Crowe JE Jr, Ritchie MD, Pendergrass SA
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Catenin delta-1 (CTNND1) phosphorylation controls the mesenchymal to epithelial transition in astrocytic tumors.
- Hum. Mol. Genet. - published August 11, 2016
- Yang J, Bassuk AG, Merl-Pham J, Hsu CW, Colgan DF, Li X, Au KS, Zhang L, Smemo S, Justus S, Nagahama Y, Grossbach AJ, Howard MA, Kawasaki H, Feldstein NA, Dobyns WB, Northrup H, Hauck SM, Ueffing M, Mahajan VB, Tsang SH
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Reprogramming towards anabolism impedes degeneration in a preclinical model of retinitis pigmentosa.
- Hum. Mol. Genet. - published August 11, 2016
- Zhang L, Justus S, Xu Y, Pluchenik T, Hsu CW, Yang J, Duong JK, Lin CS, Jia Y, Bassuk AG, Mahajan VB, Tsang SH
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tRNA-mimicry in IRES-mediated translation and recoding.
- RNA Biol - published August 11, 2016
- Butcher SE, Jan E
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Intensive treatment and survival outcomes in NUT midline carcinoma of the head and neck.
- Cancer - published August 10, 2016
- Chau NG, Hurwitz S, Mitchell CM, Aserlind A, Grunfeld N, Kaplan L, Hsi P, Bauer DE, Lathan CS, Rodriguez-Galindo C, Tishler RB, Haddad RI, Sallan SE, Bradner JE, French CA
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Capturing a substrate in an activated RING E3/E2-SUMO complex.
- Nature - published August 10, 2016
- Streich FC, Lima CD
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N-terminal domain of complexin independently activates calcium-triggered fusion.
- Proc. Natl. Acad. Sci. U.S.A. - published August 9, 2016
- Lai Y, Choi UB, Zhang Y, Zhao M, Pfuetzner RA, Wang AL, Diao J, Brunger AT
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Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.
- Proc Natl Acad Sci U S A - published August 9, 2016
- Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG
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Protein-like Nanoparticles Based on Orthogonal Self-Assembly of Chimeric Peptides.
- Small - published August 9, 2016
- Jiang L, Xu D, Namitz KE, Cosgrove MS, Lund R, Dong H
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HER2-positive breast cancer targeting and treatment by a peptide-conjugated mini nanodrug.
- Nanomedicine - published August 9, 2016
- Ding H, Gangalum PR, Galstyan A, Fox I, Patil R, Hubbard P, Murali R, Ljubimova JY, Holler E
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Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase.
- Antimicrob. Agents Chemother. - published August 8, 2016
- Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR
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PRODIGY: a web server for predicting the binding affinity of protein-protein complexes.
- Bioinformatics - published August 8, 2016
- Xue LC, Rodrigues JP, Kastritis PL, Bonvin AM, Vangone A
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An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.
- J. Exp. Med. - published August 8, 2016
- Atapattu L, Saha N, Chheang C, Eissman MF, Xu K, Vail ME, Hii L, Llerena C, Liu Z, Horvay K, Abud HE, Kusebauch U, Moritz RL, Ding BS, Cao Z, Rafii S, Ernst M, Scott AM, Nikolov DB, Lackmann M, Janes PW
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Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
- Nat Microbiol - published August 8, 2016
- Pallesen J, Murin CD, de Val N, Cottrell CA, Hastie KM, Turner HL, Fusco ML, Flyak AI, Zeitlin L, Crowe JE Jr, Andersen KG, Saphire EO, Ward AB
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Spirochaete flagella hook proteins self-catalyse a lysinoalanine covalent crosslink for motility.
- Nat Microbiol - published August 8, 2016
- Miller MR, Miller KA, Bian J, James ME, Zhang S, Lynch MJ, Callery PS, Hettick JM, Cockburn A, Liu J, Li C, Crane BR, Charon NW
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Erratum: "Ionic strength independence of charge distributions in solvation of biomolecules" [J. Chem. Phys. 141, 22D503 (2014)].
- J Chem Phys - published August 7, 2016
- Virtanen JJ, Sosnick TR, Freed KF
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Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design.
- Sci Rep - published August 6, 2016
- Broad J, Maurel D, Kung VW, Hicks GA, Schemann M, Barnes MR, Kenakin TP, Granier S, Sanger GJ
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Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES.
- J Biol Chem - published August 5, 2016
- Hall G, Cullen E, Sawmynaden K, Arnold J, Fox S, Cowan R, Muskett FW, Matthews D, Merritt A, Kettleborough C, Cruikshank W, Taylor D, Bayliss R, Carr MD
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C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.
- Science - published August 5, 2016
- Abudayyeh OO, Gootenberg JS, Konermann S, Joung J, Slaymaker IM, Cox DB, Shmakov S, Makarova KS, Semenova E, Minakhin L, Severinov K, Regev A, Lander ES, Koonin EV, Zhang F
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TakeTwo: an indexing algorithm suited to still images with known crystal parameters.
- Acta Crystallogr D Struct Biol - published August 5, 2016
- Ginn HM, Roedig P, Kuo A, Evans G, Sauter NK, Ernst OP, Meents A, Mueller-Werkmeister H, Miller RJ, Stuart DI
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Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems.
- Science - published August 5, 2016
- Mohanraju P, Makarova KS, Zetsche B, Zhang F, Koonin EV, van der Oost J
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Structures of KdnB and KdnA from Shewanella oneidensis: Key Enzymes in the Formation of 8-Amino-3,8-Dideoxy-d-Manno-Octulosonic Acid.
- Biochemistry - published August 4, 2016
- Zachman-Brockmeyer TR, Thoden JB, Holden HM
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Structural Studies on a Glucosamine/Glucosaminide N-Acetyltransferase.
- Biochemistry - published August 4, 2016
- Dopkins BJ, Tipton PA, Thoden JB, Holden HM
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Structural and Functional Investigation of FdhC from Acinetobacter nosocomialis: A Sugar N-Acyltransferase Belonging to the GNAT Superfamily.
- Biochemistry - published August 4, 2016
- Salinger AJ, Thoden JB, Holden HM
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HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing.
- Mol. Cell - published August 4, 2016
- Liu H, Liang C, Kollipara RK, Matsui M, Ke X, Jeong BC, Wang Z, Yoo KS, Yadav GP, Kinch LN, Grishin NV, Nam Y, Corey DR, Kittler R, Liu Q
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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.
- Mol. Cell - published August 4, 2016
- Garner TP, Reyna DE, Priyadarshi A, Chen HC, Li S, Wu Y, Ganesan YT, Malashkevich VN, Almo SS, Cheng EH, Gavathiotis E
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Integral Membrane Protein Expression in Saccharomyces cerevisiae.
- Methods Mol Biol - published August 4, 2016
- Boswell-Casteel RC, Johnson JM, Stroud RM, Hays FA
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Small-Scale Screening to Large-Scale Over-Expression of Human Membrane Proteins for Structural Studies.
- Methods Mol Biol - published August 4, 2016
- Chaudhary S, Saha S, Thamminana S, Stroud RM
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Fusion to a homo-oligomeric scaffold allows cryo-EM analysis of a small protein.
- Sci Rep - published August 4, 2016
- Coscia F, Estrozi LF, Hans F, Malet H, Noirclerc-Savoye M, Schoehn G, Petosa C
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Rapid molecular diagnostics of severe primary immunodeficiency determined by using targeted next-generation sequencing.
- J. Allergy Clin. Immunol. - published August 4, 2016
- Yu H, Zhang VW, Stray-Pedersen A, Hanson IC, Forbes LR, de la Morena MT, Chinn IK, Gorman E, Mendelsohn NJ, Pozos T, Wiszniewski W, Nicholas SK, Yates AB, Moore LE, Berge KE, Sorte H, Bayer DK, ALZahrani D, Geha RS, Feng Y, Wang G, Orange JS, Lupski JR, Wang J, Wong LJ
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Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia.
- Elife - published August 4, 2016
- Demircioglu FE, Sosa BA, Ingram J, Ploegh HL, Schwartz TU
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HU multimerization shift controls nucleoid compaction.
- Sci Adv - published August 3, 2016
- Hammel M, Amlanjyoti D, Reyes FE, Chen JH, Parpana R, Tang HY, Larabell CA, Tainer JA, Adhya S
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Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.
- Nature - published August 3, 2016
- Saxton RA, Chantranupong L, Knockenhauer KE, Schwartz TU, Sabatini DM
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The dimerization equilibrium of a ClC Cl(-)/H(+) antiporter in lipid bilayers.
- Elife - published August 3, 2016
- Chadda R, Krishnamani V, Mersch K, Wong J, Brimberry M, Chadda A, Kolmakova-Partensky L, Friedman LJ, Gelles J, Robertson JL
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Flexibility of the head-stalk linker domain of paramyxovirus HN glycoprotein is essential for triggering virus fusion.
- J. Virol. - published August 3, 2016
- Adu-Gyamfi E, Kim LS, Jardetzky TS, Lamb RA
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Biochemical and structural analysis of the interaction between β-amyloid and fibrinogen.
- Blood - published August 2, 2016
- Zamolodchikov D, Berk-Rauch HE, Oren DA, Stor DS, Singh PK, Kawasaki M, Aso K, Strickland S, Ahn HJ
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Role of the PFXFATG[G/Y] Motif in the Activation of SdrG, a Response Regulator Involved in the Alphaproteobacterial General Stress Response.
- Structure - published August 2, 2016
- Campagne S, Dintner S, Gottschlich L, Thibault M, Bortfeld-Miller M, Kaczmarczyk A, Francez-Charlot A, Allain FH, Vorholt JA
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Pathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence.
- Cell Rep - published August 2, 2016
- Hawman DW, Fox JM, Ashbrook AW, May NA, Schroeder KMS, Torres RM, Crowe JE Jr, Dermody TS, Diamond MS, Morrison TE
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Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein.
- Cell Rep - published August 2, 2016
- McMillan BJ, Tibbe C, Jeon H, Drabek AA, Klein T, Blacklow SC
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Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons.
- Science - published August 2, 2016
- Habib N, Li Y, Heidenreich M, Swiech L, Avraham-Davidi I, Trombetta JJ, Hession C, Zhang F, Regev A
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Label-Free Electrical Detection of Enzymatic Reactions in Nanochannels.
- ACS Nano - published August 2, 2016
- Duan C, Alibakhshi MA, Kim DK, Brown CM, Craik CS, Majumdar A
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Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).
- Clin Transl Allergy - published August 2, 2016
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Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter.
- Sci Signal - published August 2, 2016
- Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Hussain G, Duran D, Liang B, Sun D, Bönnemann CG, Delpire E
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A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex.
- Nucleic Acids Res. - published August 2, 2016
- Rodgers ML, Didychuk AL, Butcher SE, Brow DA, Hoskins AA
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Regression of chemotherapy-resistant Polymerase epsilon (POLE) ultra-mutated and MSH6 hyper-mutated endometrial tumors with nivolumab.
- Clin. Cancer Res. - published August 2, 2016
- Santin AD, Bellone S, Buza N, Choi J, Schwartz PE, Schlessinger J, Lifton RP
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Near-atomic cryo-EM structure of PRC1 bound to the microtubule.
- Proc Natl Acad Sci U S A - published August 2, 2016
- Kellogg EH, Howes S, Ti SC, Ramírez-Aportela E, Kapoor TM, Chacón P, Nogales E
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Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.
- Cell - published August 2, 2016
- Schmidt JC, Zaug AJ, Cech TR
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Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
- Cell - published August 2, 2016
- Huang P, Nedelcu D, Watanabe M, Jao C, Kim Y, Liu J, Salic A
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Opportunities and challenges in modeling human brain disorders in transgenic primates.
- Nat Neurosci - published August 2, 2016
- Jennings CG, Landman R, Zhou Y, Sharma J, Hyman J, Movshon JA, Qiu Z, Roberts AC, Roe AW, Wang X, Zhou H, Wang L, Zhang F, Desimone R, Feng G
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A critical examination of the recently reported crystal structures of the human SMN protein.
- Hum Mol Genet - published August 2, 2016
- Weiss MS, Diederichs K, Read RJ, Panjikar S, Van Duyne GD, Matera AG, Fischer U, Grimm C
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Certain (-)-epigallocatechin-3-gallate (EGCG) auto-oxidation products (EAOPs) retain the cytotoxic activities of EGCG.
- Food Chem - published August 1, 2016
- Wei Y, Chen P, Ling T, Wang Y, Dong R, Zhang C, Zhang L, Han M, Wang D, Wan X, Zhang J
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Crystal structure of the drug-resistant S31N influenza M2 proton channel.
- Protein Sci - published August 1, 2016
- Thomaston JL, DeGrado WF
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Studying Dynamics by Magic-Angle Spinning Solid-State NMR Spectroscopy: Principles and Applications to Biomolecules.
- Prog Nucl Magn Reson Spectrosc - published August 1, 2016
- Schanda P, Ernst M
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Identification of a Functionally Relevant Adeno-Associated Virus Rep68 Oligomeric Interface.
- J Virol - published August 1, 2016
- Bardelli M, Zárate-Pérez F, Agúndez L, Linden RM, Escalante CR, Henckaerts E
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Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection.
- Curr Opin Cell Biol - published August 1, 2016
- Meyers NL, Fontaine KA, Kumar GR, Ott M
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Structure of Complement C3(H2O) Revealed By Quantitative Cross-Linking/Mass Spectrometry And Modeling.
- Mol Cell Proteomics - published August 1, 2016
- Chen ZA, Pellarin R, Fischer L, Sali A, Nilges M, Barlow PN, Rappsilber J
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Self-Assembly of Measles Virus Nucleocapsid-like Particles: Kinetics and RNA Sequence Dependence.
- Angew. Chem. Int. Ed. Engl. - published August 1, 2016
- Milles S, Jensen MR, Communie G, Maurin D, Schoehn G, Ruigrok RW, Blackledge M
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Eradication of Acute Myeloid Leukemia with FLT3 Ligand-Targeted miR-150 Nanoparticles.
- Cancer Res. - published August 1, 2016
- Jiang X, Bugno J, Hu C, Yang Y, Herold T, Qi J, Chen P, Gurbuxani S, Arnovitz S, Strong J, Ferchen K, Ulrich B, Weng H, Wang Y, Huang H, Li S, Neilly MB, Larson RA, Le Beau MM, Bohlander SK, Jin J, Li Z, Bradner JE, Hong S, Chen J
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Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors.
- J Med Chem - published August 1, 2016
- Bonafoux D, Nanthakumar S, Bandarage UK, Memmott C, Lowe D, Aronov AM, Bhisetti GR, Bonanno KC, Coll J, Leeman J, Lepre CA, Lu F, Perola E, Rijnbrand R, Taylor WP, Wilson D, Zhou Y, Zwahlen J, Ter Haar E
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International AIDS Society global scientific strategy: towards an HIV cure 2016.
- Nat Med - published August 1, 2016
- Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, International AIDS Society Towards a Cure Working Group., Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J
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Determinants of VH1-46 Cross-Reactivity to Pemphigus Vulgaris Autoantigen Desmoglein 3 and Rotavirus Antigen VP6.
- J Immunol - published August 1, 2016
- Cho MJ, Ellebrecht CT, Hammers CM, Mukherjee EM, Sapparapu G, Boudreaux CE, McDonald SM, Crowe JE Jr, Payne AS
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Erratum for Metrick and Heldwein, Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21.
- J. Virol. - published August 1, 2016
- Metrick CM, Heldwein EE
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Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study.
- J Am Chem Soc - published August 1, 2016
- Elkins MR, Wang T, Nick M, Jo H, Lemmin T, Prusiner SB, DeGrado WF, Stöhr J, Hong M
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Organometallic Complex Formed by an Unconventional Radical S-Adenosylmethionine Enzyme.
- J Am Chem Soc - published August 1, 2016
- Dong M, Horitani M, Dzikovski B, Pandelia ME, Krebs C, Freed JH, Hoffman BM, Lin H
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Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.
- Nat. Struct. Mol. Biol. - published August 1, 2016
- Joyce MG, Zhang B, Ou L, Chen M, Chuang GY, Druz A, Kong WP, Lai YT, Rundlet EJ, Tsybovsky Y, Yang Y, Georgiev IS, Guttman M, Lees CR, Pancera M, Sastry M, Soto C, Stewart-Jones GB, Thomas PV, Van Galen JG, Baxa U, Lee KK, Mascola JR, Graham BS, Kwong PD
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Genetic variation in MHC proteins is associated with T cell receptor expression biases.
- Nat. Genet. - published August 1, 2016
- Sharon E, Sibener LV, Battle A, Fraser HB, Garcia KC, Pritchard JK
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Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation.
- Nat. Struct. Mol. Biol. - published August 1, 2016
- Yokom AL, Gates SN, Jackrel ME, Mack KL, Su M, Shorter J, Southworth DR
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Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition.
- Proc. Natl. Acad. Sci. U.S.A. - published August 1, 2016
- Shi X, Sousa LP, Mandel-Bausch EM, Tome F, Reshetnyak AV, Hadari Y, Schlessinger J, Lax I
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Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria.
- PLoS Negl Trop Dis - published August 1, 2016
- Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH
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Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.
- Mol Cell - published August 1, 2016
- Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA
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Analysis of protein-coding genetic variation in 60,706 humans.
- Nature - published August 1, 2016
- Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, O'Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T, Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K, Zhao F, Zou J, Pierce-Hoffman E, Berghout J, Cooper DN, Deflaux N, DePristo M, Do R, Flannick J, Fromer M, Gauthier L, Goldstein J, Gupta N, Howrigan D, Kiezun A, Kurki MI, Moonshine AL, Natarajan P, Orozco L, Peloso GM, Poplin R, Rivas MA, Ruano-Rubio V, Rose SA, Ruderfer DM, Shakir K, Stenson PD, Stevens C, Thomas BP, Tiao G, Tusie-Luna MT, Weisburd B, Won HH, Yu D, Altshuler DM, Ardissino D, Boehnke M, Danesh J, Donnelly S, Elosua R, Florez JC, Gabriel SB, Getz G, Glatt SJ, Hultman CM, Kathiresan S, Laakso M, McCarroll S, McCarthy MI, McGovern D, McPherson R, Neale BM, Palotie A, Purcell SM, Saleheen D, Scharf JM, Sklar P, Sullivan PF, Tuomilehto J, Tsuang MT, Watkins HC, Wilson JG, Daly MJ, MacArthur DG, Exome Aggregation Consortium.
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Lesion Orientation of O(4)-Alkylthymidine Influences Replication by Human DNA Polymerase η.
- Chem Sci - published August 1, 2016
- O'Flaherty DK, Patra A, Su Y, Guengerich FP, Egli M, Wilds CJ
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Sporulation, bacterial cell envelopes and the origin of life.
- Nat Rev Microbiol - published August 1, 2016
- Tocheva EI, Ortega DR, Jensen GJ
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Conformational Shift of a β-Hairpin Peptide upon Complex Formation with an Oligo-proline Peptide Studied by Mass Spectrometry.
- ChemistrySelect - published August 1, 2016
- Kölbel K, Warnke S, Seo J, von Helden G, Moretti R, Meiler J, Pagel K, Sinz A