Member Publications

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139 Member Publications for July 2016

Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis.
1. J. Mol. Biol. - published July 31, 2016
2. Xiong ZJ, Huang J, Poda G, Pomès R, Privé GG
Preparing recombinant yeast septins and their analysis by electron microscopy.
1. Methods Cell Biol - published July 31, 2016
2. Bertin A, Nogales E
A Machine Learning Approach for Hot-Spot Detection at Protein-Protein Interfaces.
1. Int J Mol Sci - published July 30, 2016
2. Melo R, Fieldhouse R, Melo A, Correia JD, Cordeiro MN, Gümüş ZH, Costa J, Bonvin AM, Moreira IS
Development of Human Monoclonal Antibodies Against Respiratory Syncytial Virus Using a High Efficiency Human Hybridoma Technique.
1. Methods Mol Biol - published July 29, 2016
2. Alvarado G, Crowe JE Jr
Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4.
1. Elife - published July 29, 2016
2. Nicoludis JM, Vogt BE, Green AG, Schärfe CP, Marks DS, Gaudet R
Compositional Control of Phase-Separated Cellular Bodies.
1. Cell - published July 28, 2016
2. Banani SF, Rice AM, Peeples WB, Lin Y, Jain S, Parker R, Rosen MK
Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis.
1. Cell - published July 28, 2016
2. Choi E, Zhang X, Xing C, Yu H
Pre-assembled Nuclear Pores Insert into the Nuclear Envelope during Early Development.
1. Cell - published July 28, 2016
2. Hampoelz B, Mackmull MT, Machado P, Ronchi P, Bui KH, Schieber N, Santarella-Mellwig R, Necakov A, Andrés-Pons A, Philippe JM, Lecuit T, Schwab Y, Beck M
Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses.
1. Cell - published July 28, 2016
2. Joyce MG, Wheatley AK, Thomas PV, Chuang GY, Soto C, Bailer RT, Druz A, Georgiev IS, Gillespie RA, Kanekiyo M, Kong WP, Leung K, Narpala SN, Prabhakaran MS, Yang ES, Zhang B, Zhang Y, Asokan M, Boyington JC, Bylund T, Darko S, Lees CR, Ransier A, Shen CH, Wang L, Whittle JR, Wu X, Yassine HM, Santos C, Matsuoka Y, Tsybovsky Y, Baxa U, NISC Comparative Sequencing Program, Mullikin JC, Subbarao K, Douek DC, Graham BS, Koup RA, Ledgerwood JE, Roederer M, Shapiro L, Kwong PD, Mascola JR, McDermott AB
Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus.
1. PLoS ONE - published July 28, 2016
2. Boyington JC, Joyce MG, Sastry M, Stewart-Jones GB, Chen M, Kong WP, Ngwuta JO, Thomas PV, Tsybovsky Y, Yang Y, Zhang B, Chen L, Druz A, Georgiev IS, Ko K, Zhou T, Mascola JR, Graham BS, Kwong PD
The structural basis of modified nucleosome recognition by 53BP1.
1. Nature - published July 27, 2016
2. Wilson MD, Benlekbir S, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
1. Nature - published July 27, 2016
2. Lee AS, Kranzusch PJ, Doudna JA, Cate JH
Small-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains.
1. J. Struct. Biol. - published July 27, 2016
2. Gakhar L, Bassuk AG, Velez G, Khan S, Yang J, Tsang SH, Mahajan VB
Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.
1. Mol. Psychiatry - published July 26, 2016
2. Kim MJ, Biag J, Fass DM, Lewis MC, Zhang Q, Fleishman M, Gangwar SP, Machius M, Fromer M, Purcell SM, McCarroll SA, Rudenko G, Premont RT, Scolnick EM, Haggarty SJ
A conserved hydrophobic core in Gαi1 regulates G protein activation and release from activated receptor.
1. J. Biol. Chem. - published July 26, 2016
2. Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE
Family-specific kinesin structures reveal neck-linker length based on initiation of the coiled-coil.
1. J. Biol. Chem. - published July 26, 2016
2. Phillips RK, Peter LG, Gilbert SP, Rayment I
Molecular Mechanisms of Enzyme Activation by Monovalent Cations.
1. J. Biol. Chem. - published July 26, 2016
2. Gohara DW, Di Cera E
Prolonged Particulate Hexavalent Chromium Exposure Suppresses Homologous Recombination Repair in Human Lung Cells.
1. Toxicol. Sci. - published July 25, 2016
2. Browning CL, Qin Q, Kelly DF, Prakash R, Vanoli F, Jasin M, Wise JP
Extended surface for membrane association in Zika virus NS1 structure.
1. Nat. Struct. Mol. Biol. - published July 25, 2016
2. Brown WC, Akey DL, Konwerski JR, Tarrasch JT, Skiniotis G, Kuhn RJ, Smith JL
Atomic resolution structure determination by the cryo-EM method MicroED.
1. Protein Sci. - published July 25, 2016
2. Liu S, Hattne J, Reyes FE, Sanchez-Martinez S, Jason de la Cruz M, Shi D, Gonen T
Salmonella infection enhances erythropoietin production by the kidney and liver correlating with elevated bacterial burdens.
1. Infect. Immun. - published July 25, 2016
2. Li LX, Benoun JM, Weiskopf K, Garcia KC, McSorley SJ
Clostridium difficile toxins TcdA and TcdB cause colonic tissue damage by distinct mechanisms.
1. Infect. Immun. - published July 25, 2016
2. Chumbler NM, Farrow MA, Lapierre LA, Franklin JL, Lacy DB
CRYSTAL STRUCTURE OF THE METALLO-BETA-LACTAMASE GOB IN THE PERIPLASMIC DI-ZINC FORM REVEALS AN UNUSUAL METAL SITE.
1. Antimicrob. Agents Chemother. - published July 25, 2016
2. Morán-Barrio J, Lisa MN, Larrieux N, Drusin SI, Viale AM, Moreno DM, Buschiazzo A, Vila AJ
Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.
1. EMBO J. - published July 25, 2016
2. Vogl C, Panou I, Yamanbaeva G, Wichmann C, Mangosing SJ, Vilardi F, Indzhykulian AA, Pangršič T, Santarelli R, Rodriguez-Ballesteros M, Weber T, Jung S, Cardenas E, Wu X, Wojcik SM, Kwan KY, Del Castillo I, Schwappach B, Strenzke N, Corey DP, Lin SY, Moser T
Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).
1. J. Biol. Chem. - published July 22, 2016
2. Fang Z, Marshall CB, Yin JC, Mazhab-Jafari MT, Gasmi-Seabrook GM, Smith MJ, Nishikawa T, Xu Y, Neel BG, Ikura M
Crystal Structures of the Iron-Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate.
1. Biochemistry - published July 22, 2016
2. Fenwick MK, Ealick SE
Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition.
1. Cell Res. - published July 22, 2016
2. Gao P, Yang H, Rajashankar KR, Huang Z, Patel DJ
Unlocking the Mechanisms of Anesthesia.
1. Anesth. Analg. - published July 22, 2016
2. Roth SH, Miller KW, Orser BA, Urban BW
Structural biology of glutamate receptor ion channel complexes.
1. Curr. Opin. Struct. Biol. - published July 22, 2016
2. Mayer ML
Accurate design of megadalton-scale two-component icosahedral protein complexes.
1. Science - published July 22, 2016
2. Bale JB, Gonen S, Liu Y, Sheffler W, Ellis D, Thomas C, Cascio D, Yeates TO, Gonen T, King NP, Baker D
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
1. Mol. Cell - published July 21, 2016
2. Wang P, Doxtader KA, Nam Y
Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20.
1. Mol. Cell - published July 21, 2016
2. Li H, Lim KS, Kim H, Hinds TR, Jo U, Mao H, Weller CE, Sun J, Chatterjee C, D'Andrea AD, Zheng N
Distinct Functions of Argonaute Slicer in siRNA Maturation and Heterochromatin Formation.
1. Mol. Cell - published July 21, 2016
2. Jain R, Iglesias N, Moazed D
Glucosylsphingosine is a key Biomarker of Gaucher Disease.
1. Am. J. Hematol. - published July 21, 2016
2. Murugesan V, Chuang WL, Liu J, Lischuk A, Kacena K, Lin H, Pastores GM, Yang R, Keutzer J, Zhang K, Mistry PK
The archiving and dissemination of biological structure data.
1. Curr. Opin. Struct. Biol. - published July 21, 2016
2. Berman HM, Burley SK, Kleywegt GJ, Markley JL, Nakamura H, Velankar S
Monochromatic multicomponent fluorescence sedimentation velocity for the study of high-affinity protein interactions.
1. Elife - published July 20, 2016
2. Zhao H, Fu Y, Glasser C, Andrade Alba EJ, Mayer ML, Patterson G, Schuck P
Microvesicle Cargo and Function Changes Upon the Induction of Cellular Transformation.
1. J. Biol. Chem. - published July 20, 2016
2. Kreger BT, Dougherty AL, Greene KS, Cerione RA, Antonyak MA
Mechanism of substrate specificity of phosphatidylinositol phosphate kinases.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 20, 2016
2. Muftuoglu Y, Xue Y, Gao X, Wu D, Ha Y
Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies.
1. Structure - published July 20, 2016
2. Davenport TM, Gorman J, Joyce MG, Zhou T, Soto C, Guttman M, Moquin S, Yang Y, Zhang B, Doria-Rose NA, Hu SL, Mascola JR, Kwong PD, Lee KK
Finding Our Way in the Dark Proteome.
1. J. Am. Chem. Soc. - published July 19, 2016
2. Bhowmick A, Brookes DH, Yost SR, Dyson HJ, Forman-Kay JD, Gunter D, Head-Gordon M, Hura GL, Pande VS, Wemmer DE, Wright PE, Head-Gordon T
Post-crystallization Improvement of RNA Crystals by Synergistic Ion Exchange and Dehydration.
1. Bio Protoc - published July 19, 2016
2. Zhang J, Ferré-D'Amaré AR
Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
1. Nat. Chem. Biol. - published July 19, 2016
2. Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM
Binding of transition metals to S100 proteins.
1. Sci China Life Sci - published July 19, 2016
2. Gilston BA, Skaar EP, Chazin WJ
Structural mechanism of ligand activation in human calcium-sensing receptor.
1. Elife - published July 19, 2016
2. Geng Y, Mosyak L, Kurinov I, Zuo H, Sturchler E, Cheng TC, Subramanyam P, Brown AP, Brennan SC, Mun HC, Bush M, Chen Y, Nguyen TX, Cao B, Chang DD, Quick M, Conigrave AD, Colecraft HM, McDonald P, Fan QR
Ribosome•RelA structures reveal the mechanism of stringent response activation.
1. Elife - published July 19, 2016
2. Loveland AB, Bah E, Madireddy R, Zhang Y, Brilot AF, Grigorieff N, Korostelev AA
Structural Architecture of Prothrombin in Solution Revealed by Single Molecule Spectroscopy.
1. J. Biol. Chem. - published July 19, 2016
2. Pozzi N, Bystranowska D, Zuo X, Di Cera E
Molecular architecture of the complete COG tethering complex.
1. Nat. Struct. Mol. Biol. - published July 18, 2016
2. Ha JY, Chou HT, Ungar D, Yip CK, Walz T, Hughson FM
Structure and function of the bacterial decapping enzyme NudC.
1. Nat. Chem. Biol. - published July 18, 2016
2. Höfer K, Li S, Abele F, Frindert J, Schlotthauer J, Grawenhoff J, Du J, Patel DJ, Jäschke A
CATCHR, HOPS and CORVET tethering complexes share a similar architecture.
1. Nat. Struct. Mol. Biol. - published July 18, 2016
2. Chou HT, Dukovski D, Chambers MG, Reinisch KM, Walz T
Flexible, symmetry-directed approach to assembling protein cages.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 18, 2016
2. Sciore A, Su M, Koldewey P, Eschweiler JD, Diffley KA, Linhares BM, Ruotolo BT, Bardwell JC, Skiniotis G, Marsh EN
Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 18, 2016
2. Shi X, Mihaylova VT, Kuruvilla L, Chen F, Viviano S, Baldassarre M, Sperandio D, Martinez R, Yue P, Bates JG, Breckenridge DG, Schlessinger J, Turk BE, Calderwood DA
Cryptosporidium and Toxoplasma parasites are inhibited by a benzoxaborole targeting leucyl-tRNA synthetase.
1. Antimicrob. Agents Chemother. - published July 18, 2016
2. Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S
Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.
1. J Am Heart Assoc - published July 16, 2016
2. van 't Hof FN, Ruigrok YM, Lee CH, Ripke S, Anderson G, de Andrade M, Baas AF, Blankensteijn JD, Böttinger EP, Bown MJ, Broderick J, Bijlenga P, Carrell DS, Crawford DC, Crosslin DR, Ebeling C, Eriksson JG, Fornage M, Foroud T, von Und Zu Fraunberg M, Friedrich CM, Gaál EI, Gottesman O, Guo DC, Harrison SC, Hernesniemi J, Hofman A, Inoue I, Jääskeläinen JE, Jones GT, Kiemeney LA, Kivisaari R, Ko N, Koskinen S, Kubo M, Kullo IJ, Kuivaniemi H, Kurki MI, Laakso A, Lai D, Leal SM, Lehto H, LeMaire SA, Low SK, Malinowski J, McCarty CA, Milewicz DM, Mosley TH, Nakamura Y, Nakaoka H, Niemelä M, Pacheco J, Peissig PL, Pera J, Rasmussen-Torvik L, Ritchie MD, Rivadeneira F, van Rij AM, Santos-Cortez RL, Saratzis A, Slowik A, Takahashi A, Tromp G, Uitterlinden AG, Verma SS, Vermeulen SH, Wang GT, Aneurysm Consortium; Vascular Research Consortium of New Zealand, Han B, Rinkel GJ, de Bakker PI
Targeting Bacterial Dsb Proteins for the Development of Anti-Virulence Agents.
1. Molecules - published July 16, 2016
2. Smith RP, Paxman JJ, Scanlon MJ, Heras B
New Insight into the Catalytic Mechanism of Bacterial MraY from Enzyme Kinetics and Docking Studies.
1. J. Biol. Chem. - published July 15, 2016
2. Liu Y, Rodrigues JP, Bonvin AM, Zaal EA, Berkers CR, Heger M, Gawarecka K, Swiezewska E, Breukink E, Egmond MR
Twenty years on: the impact of fragments on drug discovery.
1. Nat Rev Drug Discov - published July 15, 2016
2. Erlanson DA, Fesik SW, Hubbard RE, Jahnke W, Jhoti H
Structural basis for integration of GluD receptors within synaptic organizer complexes.
1. Science - published July 15, 2016
2. Elegheert J, Kakegawa W, Clay JE, Shanks NF, Behiels E, Matsuda K, Kohda K, Miura E, Rossmann M, Mitakidis N, Motohashi J, Chang VT, Siebold C, Greger IH, Nakagawa T, Yuzaki M, Aricescu AR
Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD.
1. Cell - published July 14, 2016
2. Baldridge RD, Rapoport TA
Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein.
1. PLoS One - published July 14, 2016
2. Hicar MD, Chen X, Sulli C, Barnes T, Goodman J, Sojar H, Briney B, Willis J, Chukwuma VU, Kalams SA, Doranz BJ, Spearman P, Crowe JE Jr
Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway.
1. Sci Signal - published July 14, 2016
2. Shi T, Niepel M, McDermott JE, Gao Y, Nicora CD, Chrisler WB, Markillie LM, Petyuk VA, Smith RD, Rodland KD, Sorger PK, Qian WJ, Wiley HS
Observation of an E2 (Ubc9)-homodimer by crystallography.
1. Data Brief - published July 14, 2016
2. Alontaga AY, Ambaye ND, Li YJ, Vega R, Chen CH, Bzymek KP, Williams JC, Hu W, Chen Y
An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation.
1. Science - published July 14, 2016
2. Schur FK, Obr M, Hagen WJ, Wan W, Jakobi AJ, Kirkpatrick JM, Sachse C, Kräusslich HG, Briggs JA
Intravitreal Foscarnet With Concurrent Silicone Oil Tamponade for Rhegmatogenous Retinal Detachment Secondary to Viral Retinitis.
1. Retina (Philadelphia, Pa.) - published July 14, 2016
2. Xu K, Chin EK, Mahajan VB, Almeida DR
Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.
1. J. Antibiot. - published July 13, 2016
2. Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, Joachimiak A, Phillips GN, Shen B
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
1. Nature - published July 13, 2016
2. Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ
Poliovirus Polymerase Leu420 Facilitates RNA Recombination and Ribavirin Resistance.
1. J. Virol. - published July 13, 2016
2. Kempf BJ, Peersen OB, Barton DJ
Biophysical and Biochemical Characterization of Avian Secretory Component Provides Structural Insights into the Evolution of the Polymeric Ig Receptor.
1. J. Immunol. - published July 13, 2016
2. Stadtmueller BM, Yang Z, Huey-Tubman KE, Roberts-Mataric H, Hubbell WL, Bjorkman PJ
Antigenic characterization of influenza viruses produced using synthetic DNA and novel backbones.
1. Vaccine - published July 12, 2016
2. Suphaphiphat P, Whittaker L, De Souza I, Daniels RS, Dormitzer PR, McCauley JW, Settembre EC
2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
1. Cell Rep - published July 12, 2016
2. Shalev-Benami M, Zhang Y, Matzov D, Halfon Y, Zackay A, Rozenberg H, Zimmerman E, Bashan A, Jaffe CL, Yonath A, Skiniotis G
In-Cell Protein Structures from 2D NMR Experiments.
1. J Phys Chem Lett - published July 12, 2016
2. Müntener T, Häussinger D, Selenko P, Theillet FX
Activation Mechanism of the Bacteroides fragilis Cysteine Peptidase, Fragipain.
1. Biochemistry - published July 12, 2016
2. Herrou J, Choi VM, Bubeck Wardenburg J, Crosson S
Cryo-electron Microscopy Structure of the Native Prototype Foamy Virus Glycoprotein and Virus Architecture.
1. PLoS Pathog. - published July 12, 2016
2. Effantin G, Estrozi LF, Aschman N, Renesto P, Stanke N, Lindemann D, Schoehn G, Weissenhorn W
Structural Determinants of Sleeping Beauty Transposase Activity.
1. Mol. Ther. - published July 12, 2016
2. Abrusán G, Yant SR, Szilágyi A, Marsh JA, Mátés L, Izsvák Z, Barabás O, Ivics Z
CrispRVariants charts the mutation spectrum of genome engineering experiments.
1. Nat. Biotechnol. - published July 12, 2016
2. Lindsay H, Burger A, Biyong B, Felker A, Hess C, Zaugg J, Chiavacci E, Anders C, Jinek M, Mosimann C, Robinson MD
Severe Gut Microbiota Dysbiosis Is Associated With Poor Growth in Patients With Short Bowel Syndrome.
1. JPEN J Parenter Enteral Nutr - published July 12, 2016
2. Piper HG, Fan D, Coughlin LA, Ho EX, McDaniel MM, Channabasappa N, Kim J, Kim M, Zhan X, Xie Y, Koh AY
Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.
1. Nat. Chem. Biol. - published July 11, 2016
2. Ren A, Vušurović N, Gebetsberger J, Gao P, Juen M, Kreutz C, Micura R, Patel DJ
Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.
1. Nat. Chem. Biol. - published July 11, 2016
2. Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill Iii TJ, Dennison SM, Staus DP, Thomsen AR, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, Alam SM, Sullenger BA, Lefkowitz RJ
Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion.
1. EMBO J. - published July 11, 2016
2. Malmersjö S, Di Palma S, Diao J, Lai Y, Pfuetzner RA, Wang AL, McMahon MA, Hayer A, Porteus M, Bodenmiller B, Brunger AT, Meyer T
Secondary glaucoma in CAPN5-associated neovascular inflammatory vitreoretinopathy.
1. Clin Ophthalmol - published July 9, 2016
2. Cham A, Bansal M, Banda HK, Kwon Y, Tlucek PS, Bassuk AG, Tsang SH, Sobol WM, Folk JC, Yeh S, Mahajan VB
Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences.
1. Nucleic Acids Res. - published July 8, 2016
2. Bacolla A, Tainer JA, Vasquez KM, Cooper DN
Dynamic binding of replication protein a is required for DNA repair.
1. Nucleic Acids Res - published July 8, 2016
2. Chen R, Subramanyam S, Elcock AH, Spies M, Wold MS
FoXS, FoXSDock and MultiFoXS: Single-state and multi-state structural modeling of proteins and their complexes based on SAXS profiles.
1. Nucleic Acids Res. - published July 8, 2016
2. Schneidman-Duhovny D, Hammel M, Tainer JA, Sali A
Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases.
1. J. Biol. Chem. - published July 8, 2016
2. Valencia-Sánchez MI, Rodríguez-Hernández A, Ferreira R, Santamaría-Suárez HA, Arciniega M, Dock-Bregeon AC, Moras D, Beinsteiner B, Mertens H, Svergun D, Brieba LG, Grøtli M, Torres-Larios A
Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms.
1. Sci Adv - published July 8, 2016
2. Baker P, Hill PJ, Snarr BD, Alnabelseya N, Pestrak MJ, Lee MJ, Jennings LK, Tam J, Melnyk RA, Parsek MR, Sheppard DC, Wozniak DJ, Howell PL
Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA Precursors.
1. Mol. Cell - published July 7, 2016
2. Chen YC, Stuwe E, Luo Y, Ninova M, Le Thomas A, Rozhavskaya E, Li S, Vempati S, Laver JD, Patel DJ, Smibert CA, Lipshitz HD, Fejes Toth K, Aravin AA
LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.
1. Cell Stem Cell - published July 7, 2016
2. Zhang J, Ratanasirintrawoot S, Chandrasekaran S, Wu Z, Ficarro SB, Yu C, Ross CA, Cacchiarelli D, Xia Q, Seligson M, Shinoda G, Xie W, Cahan P, Wang L, Ng SC, Tintara S, Trapnell C, Onder T, Loh YH, Mikkelsen T, Sliz P, Teitell MA, Asara JM, Marto JA, Li H, Collins JJ, Daley GQ
α-Methylation follows condensation in the gephyronic acid modular polyketide synthase.
1. Chem Commun (Camb) - published July 7, 2016
2. Wagner DT, Stevens DC, Mehaffey MR, Manion HR, Taylor RE, Brodbelt JS, Keatinge-Clay AT
Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.
1. Mol. Cell - published July 7, 2016
2. Itakura E, Zavodszky E, Shao S, Wohlever ML, Keenan RJ, Hegde RS
Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.
1. Sci Rep - published July 7, 2016
2. Ahmad S, Pecqueur L, Dreier B, Hamdane D, Aumont-Nicaise M, Plückthun A, Knossow M, Gigant B
Sensitive proton-detected solid-state NMR spectroscopy of large proteins with selective CH3 labelling: application to the 50S ribosome subunit.
1. Chem. Commun. (Camb.) - published July 7, 2016
2. Kurauskas V, Crublet E, Macek P, Kerfah R, Gauto DF, Boisbouvier J, Schanda P
Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein.
1. Mol. Cell - published July 7, 2016
2. Pak CW, Kosno M, Holehouse AS, Padrick SB, Mittal A, Ali R, Yunus AA, Liu DR, Pappu RV, Rosen MK
Heat Shock Factor 1: From Fire Chief to Crowd-Control Specialist.
1. Mol. Cell - published July 7, 2016
2. Triandafillou CG, Drummond DA
Recognition of influenza H3N2 variant virus by human neutralizing antibodies.
1. JCI Insight - published July 7, 2016
2. Bangaru S, Nieusma T, Kose N, Thornburg NJ, Finn JA, Kaplan BS, King HG, Singh V, Lampley RM, Sapparapu G, Cisneros A 3rd, Edwards KM, Slaughter JC, Edupuganti S, Lai L, Richt JA, Webby RJ, Ward AB, Crowe JE Jr
Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone.
1. Structure - published July 6, 2016
2. Chan SW, Yau J, Ing C, Liu K, Farber P, Won A, Bhandari V, Kara-Yacoubian N, Seraphim TV, Chakrabarti N, Kay LE, Yip CM, Pomès R, Sharpe S, Houry WA
ATP Is an Allosteric Inhibitor of Coxsackievirus B3 Polymerase.
1. Biochemistry - published July 6, 2016
2. Karr JP, Peersen OB
Loop Electrostatics Asymmetry Modulates the Preexisting Conformational Equilibrium in Thrombin.
1. Biochemistry - published July 6, 2016
2. Pozzi N, Zerbetto M, Acquasaliente L, Tescari S, Frezzato D, Polimeno A, Gohara DW, Di Cera E, De Filippis V
Versatile Structures of α-Synuclein.
1. Front Mol Neurosci - published July 6, 2016
2. Wang C, Zhao C, Li D, Tian Z, Lai Y, Diao J, Liu C
Structural basis for acyl-group discrimination by human Gcn5L2.
1. Acta Crystallogr D Struct Biol - published July 6, 2016
2. Ringel AE, Wolberger C
Peptide Synthesis on a Next-Generation DNA Sequencing Platform.
1. Chembiochem - published July 6, 2016
2. Svensen N, Peersen OB, Jaffrey SR
Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 6, 2016
2. Young LN, Cho K, Lawrence R, Zoncu R, Hurley JH
Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunits.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 6, 2016
2. Doamekpor SK, Lee JW, Hepowit NL, Wu C, Charenton C, Leonard M, Bengtson MH, Rajashankar KR, Sachs MS, Lima CD, Joazeiro CA
Peptide-induced de novo bone formation after tooth extraction prevents alveolar bone loss in a murine tooth extraction model.
1. Eur. J. Pharmacol. - published July 5, 2016
2. Arai Y, Aoki K, Shimizu Y, Tabata Y, Ono T, Murali R, Mise-Omata S, Wakabayashi N
Novel calmodulin mutations associated with congenital long QT syndrome affect calcium current in human cardiomyocytes.
1. Heart Rhythm - published July 5, 2016
2. Pipilas DC, Johnson CN, Webster G, Schlaepfer J, Fellmann F, Sekarski N, Wren LM, Ogorodnik KV, Chazin DM, Chazin WJ, Crotti L, Bhuiyan ZA, George AL
The heterodimeric ABC transporter EfrCD mediates multidrug efflux in Enterococcus faecalis.
1. Antimicrob. Agents Chemother. - published July 5, 2016
2. Hürlimann LM, Corradi V, Hohl M, Bloemberg GV, Tieleman DP, Seeger MA
DNA Polymerase-γ R953C Mutant is Associated with ART-Induced Mitochondrial Toxicity.
1. Antimicrob. Agents Chemother. - published July 5, 2016
2. Li M, Mislak AC, Foli Y, Agbosu E, Bose V, Bhandari S, Szymanski MR, Shumate CK, Yin YW, Anderson KS, Paintsil E
Structure and Function of the PriC DNA Replication Restart Protein.
1. J. Biol. Chem. - published July 5, 2016
2. Wessel SR, Cornilescu CC, Cornilescu G, Metz A, Leroux M, Hu K, Sandler SJ, Markley JL, Keck JL
A non-oligomerizing mutant form of Helicobacter pylori VacA allows structural analysis of the p33 domain.
1. Infect. Immun. - published July 5, 2016
2. González-Rivera C, Campbell AM, Rutherford SA, Pyburn TM, Foegeding NJ, Barke TL, Spiller BW, McClain MS, Ohi MD, Lacy DB, Cover TL
Group II Intron Self-Splicing.
1. Annu Rev Biophys - published July 5, 2016
2. Pyle AM
In Vitro Chromatin Assembly: Strategies and Quality Control.
1. Meth. Enzymol. - published July 4, 2016
2. Muthurajan U, Mattiroli F, Bergeron S, Zhou K, Gu Y, Chakravarthy S, Dyer P, Irving T, Luger K
Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function.
1. Nucleic Acids Res. - published July 4, 2016
2. Chillón I, Pyle AM
First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.
1. Biochim. Biophys. Acta - published July 3, 2016
2. Yurtsever Z, Patel DA, Kober DL, Su A, Miller CA, Romero AG, Holtzman MJ, Brett TJ
Synergy between NMR measurements and MD simulations of protein/RNA complexes: application to the RRMs, the most common RNA recognition motifs.
1. Nucleic Acids Res - published July 2, 2016
2. Krepl M, Cléry A, Blatter M, Allain FH, Sponer J
The HIV-1 Tat Protein Is Monomethylated at Lysine 71 by the Lysine Methyltransferase KMT7.
1. J Biol Chem - published July 2, 2016
2. Ali I, Ramage H, Boehm D, Dirk LM, Sakane N, Hanada K, Pagans S, Kaehlcke K, Aull K, Weinberger L, Trievel R, Schnoelzer M, Kamada M, Houtz R, Ott M
The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2 T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of Cells.
1. J Biol Chem - published July 2, 2016
2. Duan Y, Ma G, Huang X, D'Amore PA, Zhang F, Lei H
Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress.
1. Elife - published July 2, 2016
2. Gallagher CM, Walter P
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.
1. Elife - published July 2, 2016
2. Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, Hodder P, Wiseman RL, Kelly JW
Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch.
1. Elife - published July 2, 2016
2. Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P
Expression, Purification and Crystallization of the Herpesvirus Nuclear Egress Complex (NEC).
1. Bio Protoc - published July 2, 2016
2. Bigalke JM, Heldwein EE
Next-generation sequencing yields the complete mitochondrial genome of the longfang moray, Enchelynassa canina (Anguilliformes: Muraenidae).
1. Mitochondrial DNA A DNA Mapp Seq Anal - published July 1, 2016
2. Loh KH, Shao KT, Chen HM, Chen CH, Loo PL, Hui AT, Lim PE, Chong VC, Shen KN, Hsiao CD
Complete mitogenome of two moray eels of Gymnothorax formosus and Scuticaria tigrina (Anguilliformes: Muraenidae).
1. Mitochondrial DNA A DNA Mapp Seq Anal - published July 1, 2016
2. Loh KH, Shao KT, Chen CH, Chen HM, Then AY, Loo PL, Lim PE, Chong VC, Shen KN, Hsiao CD
Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles.
1. Trends Microbiol - published July 1, 2016
2. van der Schaar HM, Dorobantu CM, Albulescu L, Strating JRPM, van Kuppeveld FJM
Characterization of Epitope-Specific Anti-Respiratory Syncytial Virus (Anti-RSV) Antibody Responses after Natural Infection and after Vaccination with Formalin-Inactivated RSV.
1. J Virol - published July 1, 2016
2. Widjaja I, Wicht O, Luytjes W, Leenhouts K, Rottier PJM, van Kuppeveld FJM, Haijema BJ, de Haan CAM
Rearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor Activation.
1. J. Biol. Chem. - published July 1, 2016
2. Schaarschmidt J, Nagel MB, Huth S, Jaeschke H, Moretti R, Hintze V, von Bergen M, Kalkhof S, Meiler J, Paschke R
Coordinate action of distinct sequence elements localizes checkpoint kinase Hsl1 to the septin collar at the bud neck in Saccharomyces cerevisiae.
1. Mol Biol Cell - published July 1, 2016
2. Finnigan GC, Sterling SM, Duvalyan A, Liao EN, Sargsyan A, Garcia G 3rd, Nogales E, Thorner J
Photoactivatable protein labeling by singlet oxygen mediated reactions.
1. Bioorg Med Chem Lett - published July 1, 2016
2. To TL, Medzihradszky KF, Burlingame AL, DeGrado WF, Jo H, Shu X
Higher-order oligomerization of Spc110p drives γ-tubulin ring complex assembly.
1. Mol Biol Cell - published July 1, 2016
2. Lyon AS, Morin G, Moritz M, Yabut KC, Vojnar T, Zelter A, Muller E, Davis TN, Agard DA
Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η.
1. J. Biol. Chem. - published July 1, 2016
2. Patra A, Su Y, Zhang Q, Johnson KM, Guengerich FP, Egli M
Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation.
1. Science - published July 1, 2016
2. Gibson BA, Zhang Y, Jiang H, Hussey KM, Shrimp JH, Lin H, Schwede F, Yu Y, Kraus WL
Methyltransferases excised from trans-AT polyketide synthases operate on N-acetylcysteamine-bound substrates.
1. J Antibiot (Tokyo) - published July 1, 2016
2. Stevens DC, Wagner DT, Manion HR, Alexander BK, Keatinge-Clay AT
Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8.
1. Proc Natl Acad Sci U S A - published July 1, 2016
2. Pröpster JM, Yang F, Rabbani S, Ernst B, Allain FH, Schubert M
Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy.
1. Science - published July 1, 2016
2. Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI
Protein Complex Purification by Affinity Capture.
1. Cold Spring Harb Protoc - published July 1, 2016
2. LaCava J, Fernandez-Martinez J, Hakhverdyan Z, Rout MP
Density Gradient Ultracentrifugation to Isolate Endogenous Protein Complexes after Affinity Capture.
1. Cold Spring Harb Protoc - published July 1, 2016
2. Fernandez-Martinez J, LaCava J, Rout MP
Optimized Affinity Capture of Yeast Protein Complexes.
1. Cold Spring Harb Protoc - published July 1, 2016
2. LaCava J, Fernandez-Martinez J, Hakhverdyan Z, Rout MP
Native Elution of Yeast Protein Complexes Obtained by Affinity Capture.
1. Cold Spring Harb Protoc - published July 1, 2016
2. LaCava J, Fernandez-Martinez J, Rout MP
Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 1, 2016
2. Huang WY, Yan Q, Lin WC, Chung JK, Hansen SD, Christensen SM, Tu HL, Kuriyan J, Groves JT
HIV-host interactome revealed directly from infected cells.
1. Nat Microbiol - published July 1, 2016
2. Luo Y, Jacobs EY, Greco TM, Mohammed KD, Tong T, Keegan S, Binley JM, Cristea IM, Fenyö D, Rout MP, Chait BT, Muesing MA
Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells.
1. Elife - published July 1, 2016
2. Hengel SR, Malacaria E, Folly da Silva Constantino L, Bain FE, Diaz A, Koch BG, Yu L, Wu M, Pichierri P, Spies MA, Spies M
Static Clathrin Assemblies at the Peripheral Vacuole-Plasma Membrane Interface of the Parasitic Protozoan Giardia lamblia.
1. PLoS Pathog - published July 1, 2016
2. Zumthor JP, Cernikova L, Rout S, Kaech A, Faso C, Hehl AB