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147 Member Publications for June 2016

UtpA and UtpB chaperone nascent pre-ribosomal RNA and U3 snoRNA to initiate eukaryotic ribosome assembly.
1. Nat Commun - published June 30, 2016
2. Hunziker M, Barandun J, Petfalski E, Tan D, Delan-Forino C, Molloy KR, Kim KH, Dunn-Davies H, Shi Y, Chaker-Margot M, Chait BT, Walz T, Tollervey D, Klinge S
Dual effect of histone H4 on prothrombin activation.
1. J. Thromb. Haemost. - published June 30, 2016
2. Pozzi N, Di Cera E
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 29, 2016
2. Guaitoli G, Raimondi F, Gilsbach BK, Gómez-Llorente Y, Deyaert E, Renzi F, Li X, Schaffner A, Jagtap PK, Boldt K, von Zweydorf F, Gotthardt K, Lorimer DD, Yue Z, Burgin A, Janjic N, Sattler M, Versées W, Ueffing M, Ubarretxena-Belandia I, Kortholt A, Gloeckner CJ
Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling.
1. Cell Rep - published June 28, 2016
2. Hwang SY, Deng X, Byun S, Lee C, Lee SJ, Suh H, Zhang J, Kang Q, Zhang T, Westover KD, Mandinova A, Lee SW
Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer.
1. Nat Microbiol - published June 28, 2016
2. Kabanova A, Marcandalli J, Zhou T, Bianchi S, Baxa U, Tsybovsky Y, Lilleri D, Silacci-Fregni C, Foglierini M, Fernandez-Rodriguez BM, Druz A, Zhang B, Geiger R, Pagani M, Sallusto F, Kwong PD, Corti D, Lanzavecchia A, Perez L
New hardware and workflows for semi-automated correlative cryo-fluorescence and cryo-electron microscopy/tomography.
1. J. Struct. Biol. - published June 28, 2016
2. Schorb M, Gaechter L, Avinoam O, Sieckmann F, Clarke M, Bebeacua C, Bykov YS, Sonnen AF, Lihl R, Briggs JA
CSAR Benchmark Exercise 2013: Evaluation of Results from a Combined Computational Protein Design, Docking, and Scoring/Ranking Challenge.
1. J Chem Inf Model - published June 27, 2016
2. Smith RD, Damm-Ganamet KL, Dunbar JB, Ahmed A, Chinnaswamy K, Delproposto JE, Kubish GM, Tinberg CE, Khare SD, Dou J, Doyle L, Stuckey JA, Baker D, Carlson HA
CSAR 2014: A Benchmark Exercise Using Unpublished Data from Pharma.
1. J Chem Inf Model - published June 27, 2016
2. Carlson HA, Smith RD, Damm-Ganamet KL, Stuckey JA, Ahmed A, Convery MA, Somers DO, Kranz M, Elkins PA, Cui G, Peishoff CE, Lambert MH, Dunbar JB
A gene cluster for the biosynthesis of moenomycin family antibiotics in the genome of teicoplanin producer Actinoplanes teichomyceticus.
1. Appl. Microbiol. Biotechnol. - published June 27, 2016
2. Horbal L, Ostash B, Luzhetskyy A, Walker S, Kalinowski J, Fedorenko V
Peptide drugs accelerate BMP-2-induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling.
1. Bioessays - published June 27, 2016
2. Sugamori Y, Mise-Omata S, Maeda C, Aoki S, Tabata Y, Murali R, Yasuda H, Udagawa N, Suzuki H, Honma M, Aoki K
Atypical calcium regulation of the PKD2-L1 polycystin ion channel.
1. Elife - published June 27, 2016
2. DeCaen PG, Liu X, Abiria S, Clapham DE
CTLA-4 limits anti-CD20-mediated tumor regression.
1. Clin. Cancer Res. - published June 27, 2016
2. Ren Z, Guo J, Liao J, Luan Y, Liu Z, Sun Z, Liu X, Liang Y, Peng H, Fu YX
The assembly of C. elegans lamins into macroscopic fibers.
1. J Mech Behav Biomed Mater - published June 25, 2016
2. Zingerman-Koladko I, Khayat M, Harapin J, Shoseyov O, Gruenbaum Y, Salman A, Medalia O, Ben-Harush K
Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies.
1. Elife - published June 25, 2016
2. Carlson LA, Bai Y, Keane SC, Doudna JA, Hurley JH
Clathrin modulates vesicle scission, but not invagination shape, in yeast endocytosis.
1. Elife - published June 24, 2016
2. Kukulski W, Picco A, Specht T, Briggs JA, Kaksonen M
The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels.
1. Nat Commun - published June 23, 2016
2. Bavi N, Cortes DM, Cox CD, Rohde PR, Liu W, Deitmer JW, Bavi O, Strop P, Hill AP, Rees D, Corry B, Perozo E, Martinac B
Structural basis for membrane anchoring of HIV-1 envelope spike.
1. Science - published June 23, 2016
2. Dev J, Park D, Fu Q, Chen J, Ha HJ, Ghantous F, Herrmann T, Chang W, Liu Z, Frey G, Seaman MS, Chen B, Chou JJ
Structure of the frequency-interacting RNA helicase: a protein interaction hub for the circadian clock.
1. EMBO J. - published June 23, 2016
2. Conrad KS, Hurley JM, Widom J, Ringelberg CS, Loros JJ, Dunlap JC, Crane BR
Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 23, 2016
2. Shu B, Gong P
Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases.
1. Biochemistry - published June 22, 2016
2. Chen Z, Thomas SN, Bolduc DM, Jiang X, Zhang X, Wolberger C, Cole PA
Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 22, 2016
2. Song AS, Poor TA, Abriata LA, Jardetzky TS, Dal Peraro M, Lamb RA
Multiple Calmodulin-binding Sites Positively and Negatively Regulate Arabidopsis CYCLIC NUCLEOTIDE-GATED CHANNEL12.
1. Plant Cell - published June 22, 2016
2. DeFalco TA, Marshall CB, Munro K, Kang HG, Moeder W, Ikura M, Snedden WA, Yoshioka K
Lipids regulate Lck activity through their interactions with the Lck SH2 domain.
1. J. Biol. Chem. - published June 22, 2016
2. Sheng R, Jung DJ, Silkov A, Kim H, Singaram I, Wang ZG, Xin Y, Kim E, Park MJ, Thiagarajan-Rosenkranz P, Smrt S, Honig B, Baek K, Ryu S, Lorieau J, Kim YM, Cho W
Mutagenesis of Paramyxovirus Hemagglutinin-Neuraminidase Membrane Proximal Stalk Region Influences Stability, Receptor Binding and Neuraminidase Activity.
1. J. Virol. - published June 22, 2016
2. Adu-Gyamfi E, Kim LS, Jardetzky TS, Lamb RA
Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example.
1. J. Am. Chem. Soc. - published June 21, 2016
2. Oyala PH, Ravichandran KR, Funk MA, Stucky PA, Stich TA, Drennan CL, Britt RD, Stubbe J
Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.
1. Leukemia - published June 21, 2016
2. Hing ZA, Fung HY, Ranganathan P, Mitchell S, El-Gamal D, Woyach JA, Williams K, Goettl VM, Smith J, Yu X, Meng X, Sun Q, Cagatay T, Lehman AM, Lucas DM, Baloglu E, Shacham S, Kauffman MG, Byrd JC, Chook YM, Garzon R, Lapalombella R
Contrasting Effects of the γ-Aminobutyric Acid Type A Receptor β3 Subunit N265M Mutation on Loss of Righting Reflexes Induced by Etomidate and the Novel Anesthetic Barbiturate R-mTFD-MPAB.
1. Anesth. Analg. - published June 21, 2016
2. Amlong CA, Perkins MG, Houle TT, Miller KW, Pearce RA
Ultrastructural Analysis of Self-Associated RyR2s.
1. Biophys. J. - published June 21, 2016
2. Cabra V, Murayama T, Samsó M
Artesunate ameliorates severe acute pancreatitis (SAP) in rats by inhibiting expression of pro-inflammatory cytokines and Toll-like receptor 4.
1. Int. Immunopharmacol. - published June 20, 2016
2. Cen Y, Liu C, Li X, Yan Z, Kuang M, Su Y, Pan X, Qin R, Liu X, Zheng J, Zhou H
Identifying the functional contribution of the defatty-acylase activity of SIRT6.
1. Nat. Chem. Biol. - published June 20, 2016
2. Zhang X, Khan S, Jiang H, Antonyak MA, Chen X, Spiegelman NA, Shrimp JH, Cerione RA, Lin H
Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.
1. Nucleic Acids Res. - published June 20, 2016
2. Kozel C, Thompson B, Hustak S, Moore C, Nakashima A, Singh CR, Reid M, Cox C, Papadopoulos E, Luna RE, Anderson A, Tagami H, Hiraishi H, Slone EA, Yoshino KI, Asano M, Gillaspie S, Nietfeld J, Perchellet JP, Rothenburg S, Masai H, Wagner G, Beeser A, Kikkawa U, Fleming SD, Asano K
A Potential Structural Switch for Regulating DNA-Binding by TEAD Transcription Factors.
1. J. Mol. Biol. - published June 19, 2016
2. Lee DS, Vonrhein C, Albarado D, Raman CS, Veeraraghavan S
Defining the limits and reliability of rigid-body fitting in cryo-EM maps using multi-scale image pyramids.
1. J. Struct. Biol. - published June 19, 2016
2. van Zundert GC, Bonvin AM
Genome-wide association study of pathological gambling.
1. Eur. Psychiatry - published June 18, 2016
2. Lang M, Leménager T, Streit F, Fauth-Bühler M, Frank J, Juraeva D, Witt SH, Degenhardt F, Hofmann A, Heilmann-Heimbach S, Kiefer F, Brors B, Grabe HJ, John U, Bischof A, Bischof G, Völker U, Homuth G, Beutel M, Lind PA, Medland SE, Slutske WS, Martin NG, Völzke H, Nöthen MM, Meyer C, Rumpf HJ, Wurst FM, Rietschel M, Mann KF
Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin.
1. J. Biol. Chem. - published June 17, 2016
2. Vemu A, Atherton J, Spector JO, Szyk A, Moores CA, Roll-Mecak A
Bacillus anthracis Prolyl 4-Hydroxylase Modifies Collagen-like Substrates in Asymmetric Patterns.
1. J. Biol. Chem. - published June 17, 2016
2. Schnicker NJ, Dey M
Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length.
1. Nat Commun - published June 17, 2016
2. Zheng X, Ramani A, Soni K, Gottardo M, Zheng S, Ming Gooi L, Li W, Feng S, Mariappan A, Wason A, Widlund P, Pozniakovsky A, Poser I, Deng H, Ou G, Riparbelli M, Giuliano C, Hyman AA, Sattler M, Gopalakrishnan J, Li H
The complexity of life and death decisions in mitosis.
1. Mol Cell Oncol - published June 17, 2016
2. Diaz-Martinez LA, Yu H
Chemical genetics: Unraveling cell death mysteries.
1. Nat. Chem. Biol. - published June 17, 2016
2. Cotto-Rios XM, Gavathiotis E
Bayesian Factor Analysis as a Variable-Selection Problem: Alternative Priors and Consequences.
1. Multivariate Behav Res - published June 17, 2016
2. Lu ZH, Chow SM, Loken E
Relating conformation to function in integrin α5β1.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 17, 2016
2. Su Y, Xia W, Li J, Walz T, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA
CRISPR Immunological Memory Requires a Host Factor for Specificity.
1. Mol. Cell - published June 16, 2016
2. Nuñez JK, Bai L, Harrington LB, Hinder TL, Doudna JA
Engineering Recombinant Reoviruses To Display gp41 Membrane-Proximal External-Region Epitopes from HIV-1.
1. mSphere - published June 16, 2016
2. Boehme KW, Ikizler M, Iskarpatyoti JA, Wetzel JD, Willis J, Crowe JE Jr, LaBranche CC, Montefiori DC, Wilson GJ, Dermody TS
Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein.
1. mSphere - published June 16, 2016
2. Dorobantu CM, Albulescu L, Lyoo H, van Kampen M, De Francesco R, Lohmann V, Harak C, van der Schaar HM, Strating JR, Gorbalenya AE, van Kuppeveld FJ
Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.
1. PLoS Pathog. - published June 16, 2016
2. Reguera J, Gerlach P, Rosenthal M, Gaudon S, Coscia F, Günther S, Cusack S
Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation.
1. Nat Commun - published June 16, 2016
2. Desrochers LM, Bordeleau F, Reinhart-King CA, Cerione RA, Antonyak MA
The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction.
1. Nat Commun - published June 16, 2016
2. Wakeman CA, Moore JL, Noto MJ, Zhang Y, Singleton MD, Prentice BM, Gilston BA, Doster RS, Gaddy JA, Chazin WJ, Caprioli RM, Skaar EP
Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway.
1. Acta Crystallogr D Struct Biol - published June 16, 2016
2. Hicks KA, Ealick SE
Crystal structure of a chimaeric bacterial glutamate dehydrogenase.
1. Acta Crystallogr F Struct Biol Commun - published June 16, 2016
2. Oliveira T, Sharkey MA, Engel PC, Khan AR
Cyclization strategies of meditopes: affinity and diffraction studies of meditope-Fab complexes.
1. Acta Crystallogr F Struct Biol Commun - published June 16, 2016
2. Bzymek KP, Ma Y, Avery KA, Horne DA, Williams JC
Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in Endothelial Cells.
1. mSphere - published June 16, 2016
2. Craven R, Lacy DB
Structural organization of membrane-inserted hexamers formed by Helicobacter pylori VacA toxin.
1. Mol. Microbiol. - published June 16, 2016
2. Pyburn TM, Foegeding NJ, González-Rivera C, McDonald NA, Gould KL, Cover TL, Ohi MD
Human sterol 14α-demethylase (CYP51) as a target for anticancer chemotherapy: Towards structure-aided drug design.
1. J. Lipid Res. - published June 16, 2016
2. Hargrove TY, Friggeri L, Wawrzak Z, Sivakumaran S, Yazlovitskaya EM, Hiebert SW, Guengerich FP, Waterman MR, Lepesheva GI
Oncogenic deregulation of EZH2 as an opportunity for targeted therapy in lung cancer.
1. Cancer Discov - published June 16, 2016
2. Zhang H, Qi J, Reyes JM, Li L, Rao PK, Li F, Lin CY, Perry JA, Lawlor MA, Federation A, De Raedt T, Li YY, Liu Y, Duarte MA, Zhang Y, Herter-Sprie GS, Kikuchi E, Carretero J, Perou CM, Reibel JB, Paulk J, Bronson RT, Watanabe H, Fillmore CM, Kim CF, Hammerman PS, Brown M, Cichowski K, Long H, Bradner JE, Wong KK
Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP).
1. Bioorg. Med. Chem. - published June 15, 2016
2. Korwar S, Morris BL, Parikh HI, Coover RA, Doughty TW, Love IM, Hilbert BJ, Royer WE, Kellogg GE, Grossman SR, Ellis KC
Classic Spotlight: Studies of the Stringent Response.
1. J. Bacteriol. - published June 15, 2016
2. Gourse RL, Crosson S
Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8.
1. PLoS ONE - published June 15, 2016
2. Soto C, Ofek G, Joyce MG, Zhang B, McKee K, Longo NS, Yang Y, Huang J, Parks R, Eudailey J, Lloyd KE, Alam SM, Haynes BF, NISC Comparative Sequencing Program, Mullikin JC, Connors M, Mascola JR, Shapiro L, Kwong PD
Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein.
1. PLoS Pathog. - published June 15, 2016
2. Fernández-García Y, Reguera J, Busch C, Witte G, Sánchez-Ramos O, Betzel C, Cusack S, Günther S, Reindl S
Enhancer regions show high histone H3.3 turnover that changes during differentiation.
1. Elife - published June 15, 2016
2. Deaton AM, Gómez-Rodríguez M, Mieczkowski J, Tolstorukov MY, Kundu S, Sadreyev RI, Jansen LE, Kingston RE
Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors.
1. Elife - published June 15, 2016
2. Yamamoto K, Wang J, Sprinzen L, Xu J, Haddock CJ, Li C, Lee BJ, Loredan DG, Jiang W, Vindigni A, Wang D, Rabadan R, Zha S
Structure of human Niemann-Pick C1 protein.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 15, 2016
2. Li X, Wang J, Coutavas E, Shi H, Hao Q, Blobel G
Deprotonations in the Reaction of Flavin-Dependent Thymidylate Synthase.
1. Biochemistry - published June 14, 2016
2. Stull FW, Bernard SM, Sapra A, Smith JL, Zuiderweg ER, Palfey BA
Natural polymerase fusion as an initiation regulator?
1. Oncotarget - published June 14, 2016
2. Lu G, Gong P
Discovery of Small-Molecule Modulators of the Human Y4 Receptor.
1. PLoS ONE - published June 14, 2016
2. Sliwoski G, Schubert M, Stichel J, Weaver D, Beck-Sickinger AG, Meiler J
Structural basis for phospholipid scrambling in the TMEM16 family.
1. Curr. Opin. Struct. Biol. - published June 14, 2016
2. Brunner JD, Schenck S, Dutzler R
Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.
1. Nucleic Acids Res. - published June 14, 2016
2. Wan LC, Pillon MC, Thevakumaran N, Sun Y, Chakrabartty A, Guarné A, Kurinov I, Durocher D, Sicheri F
A structural phylogeny for understanding 2-oxoacid oxidoreductase function.
1. Curr. Opin. Struct. Biol. - published June 14, 2016
2. Gibson MI, Chen PY, Drennan CL
Implementation of a cryo-electron tomography tilt-scheme optimized for high resolution subtomogram averaging.
1. J. Struct. Biol. - published June 14, 2016
2. Hagen WJ, Wan W, Briggs JA
The conserved TPR-containing C-terminal domain of Pseudomonas aeruginosa FimV is required for its cAMP-dependent and independent functions.
1. J. Bacteriol. - published June 13, 2016
2. Buensuceso RN, Nguyen Y, Zhang K, Daniel-Ivad M, Sugiman-Marangos SN, Fleetwood AD, Zhulin IB, Junop MS, Howell PL, Burrows LL
Structural basis of adhesive binding by desmocollins and desmogleins.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 13, 2016
2. Harrison OJ, Brasch J, Lasso G, Katsamba PS, Ahlsen G, Honig B, Shapiro L
Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 13, 2016
2. Goricanec D, Stehle R, Egloff P, Grigoriu S, Plückthun A, Wagner G, Hagn F
Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 13, 2016
2. Shu Q, Krezel AM, Cusumano ZT, Pinkner JS, Klein R, Hultgren SJ, Frieden C
Inositol Polyphosphate Binding Specificity of the Jasmonate Receptor Complex.
1. Plant Physiol. - published June 12, 2016
2. Laha D, Parvin N, Dynowski M, Johnen P, Mao H, Bitters ST, Zheng N, Schaaf G
Biofilm Exopolysaccharides of Pathogenic Fungi: Lessons from Bacteria.
1. J. Biol. Chem. - published June 10, 2016
2. Sheppard DC, Howell PL
Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment.
1. PLoS Pathog. - published June 10, 2016
2. Bender RR, Muth A, Schneider IC, Friedel T, Hartmann J, Plückthun A, Maisner A, Buchholz CJ
NrdR Transcription Regulation: Global Proteome Analysis and Its Role in Escherichia coli Viability and Virulence.
1. PLoS One - published June 9, 2016
2. Naveen V, Hsiao CD
Sestrin regulation of TORC1: Is Sestrin a leucine sensor?
1. Sci Signal - published June 9, 2016
2. Lee JH, Cho US, Karin M
Evolution of High Cellulolytic Activity in Symbiotic Streptomyces through Selection of Expanded Gene Content and Coordinated Gene Expression.
1. PLoS Biol. - published June 9, 2016
2. Book AJ, Lewin GR, McDonald BR, Takasuka TE, Wendt-Pienkowski E, Doering DT, Suh S, Raffa KF, Fox BG, Currie CR
An Introduction to Programming for Bioscientists: A Python-Based Primer.
1. PLoS Comput. Biol. - published June 9, 2016
2. Ekmekci B, McAnany CE, Mura C
Higher-order assemblies of oligomeric cargo receptor complexes form the membrane scaffold of the Cvt vesicle.
1. EMBO Rep. - published June 9, 2016
2. Bertipaglia C, Schneider S, Jakobi AJ, Tarafder AK, Bykov YS, Picco A, Kukulski W, Kosinski J, Hagen WJ, Ravichandran AC, Wilmanns M, Kaksonen M, Briggs JA, Sachse C
Recent Structural Insights into Cytochrome P450 Function.
1. Trends Pharmacol. Sci. - published June 9, 2016
2. Guengerich FP, Waterman MR, Egli M
Toward the atomic structure of the nuclear pore complex: when top down meets bottom up.
1. Nat. Struct. Mol. Biol. - published June 9, 2016
2. Hoelz A, Glavy JS, Beck M
Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase.
1. Antimicrob. Agents Chemother. - published June 9, 2016
2. Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, Cusack S, Rosenthal PJ
Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence.
1. Mol. Hum. Reprod. - published June 9, 2016
2. Molinari E, Bar H, Pyle AM, Patrizio P
Exploring the interplay between experimental methods and the performance of predictors of binding affinity change upon mutations in protein complexes.
1. Protein Eng. Des. Sel. - published June 9, 2016
2. Geng C, Vangone A, Bonvin AM
The CENP-T/-W complex is a binding partner of the histone chaperone FACT.
1. Genes Dev. - published June 9, 2016
2. Prendergast L, Müller S, Liu Y, Huang H, Dingli F, Loew D, Vassias I, Patel DJ, Sullivan KF, Almouzni G
Intracellular Action of a Secreted Peptide Required for Fungal Virulence.
1. Cell Host Microbe - published June 8, 2016
2. Homer CM, Summers DK, Goranov AI, Clarke SC, Wiesner DL, Diedrich JK, Moresco JJ, Toffaletti D, Upadhya R, Caradonna I, Petnic S, Pessino V, Cuomo CA, Lodge JK, Perfect J, Yates JR 3rd, Nielsen K, Craik CS, Madhani HD
Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3.
1. J. Biol. Chem. - published June 8, 2016
2. Kim S, Natesan S, Cornilescu G, Carlson S, Tonelli M, McClurg UL, Binda O, Robson CN, Markley JL, Balaz S, Glass KC
G-quadruplex RNA binding and recognition by the lysine-specific histone demethylase-1 enzyme.
1. RNA - published June 8, 2016
2. Hirschi A, Martin WJ, Luka Z, Loukachevitch LV, Reiter NJ
The Response of Acinetobacter baumannii to Zinc Starvation.
1. Cell Host Microbe - published June 8, 2016
2. Nairn BL, Lonergan ZR, Wang J, Braymer JJ, Zhang Y, Calcutt MW, Lisher JP, Gilston BA, Chazin WJ, de Crécy-Lagard V, Giedroc DP, Skaar EP
Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.
1. J. Biol. Chem. - published June 8, 2016
2. Lawrence CF, Margetts MB, Menting JG, Smith NA, Smith BJ, Ward CW, Lawrence MC
Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration.
1. Cell Host Microbe - published June 8, 2016
2. Diaz-Ochoa VE, Lam D, Lee CS, Klaus S, Behnsen J, Liu JZ, Chim N, Nuccio SP, Rathi SG, Mastroianni JR, Edwards RA, Jacobo CM, Cerasi M, Battistoni A, Ouellette AJ, Goulding CW, Chazin WJ, Skaar EP, Raffatellu M
Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites.
1. Structure - published June 7, 2016
2. Simon B, Huart AS, Temmerman K, Vahokoski J, Mertens HD, Komadina D, Hoffmann JE, Yumerefendi H, Svergun DI, Kursula P, Schultz C, McCarthy AA, Hart DJ, Wilmanns M
Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model.
1. Oncotarget - published June 7, 2016
2. Suarez ER, Chang de K, Sun J, Sui J, Freeman GJ, Signoretti S, Zhu Q, Marasco WA
The Structure of a Sugar Transporter of the Glucose EIIC Superfamily Provides Insight into the Elevator Mechanism of Membrane Transport.
1. Structure - published June 7, 2016
2. McCoy JG, Ren Z, Stanevich V, Lee J, Mitra S, Levin EJ, Poget S, Quick M, Im W, Zhou M
A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1.
1. Cell Rep - published June 7, 2016
2. Nnamani MC, Ganguly S, Erkenbrack EM, Lynch VJ, Mizoue LS, Tong Y, Darling HL, Fuxreiter M, Meiler J, Wagner GP
Reverse transcriptases lend a hand in splicing catalysis.
1. Nat. Struct. Mol. Biol. - published June 7, 2016
2. Piccirilli JA, Staley JP
A pH-Mediated Topological Switch within the N-Terminal Domain of Human Caveolin-3.
1. Biophys. J. - published June 7, 2016
2. Kim JH, Schlebach JP, Lu Z, Peng D, Reasoner KC, Sanders CR
Competition between Coiled-Coil Structures and the Impact on Myosin-10 Bundle Selection.
1. Biophys. J. - published June 7, 2016
2. Vavra KC, Xia Y, Rock RS
Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer.
1. Nat. Struct. Mol. Biol. - published June 7, 2016
2. Lees-Miller SP, Beattie TL, Tainer JA
Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction.
1. Curr. Opin. Struct. Biol. - published June 7, 2016
2. Guo B, McMillan BJ, Blacklow SC
Gold nanoparticle capture within protein crystal scaffolds.
1. Nanoscale - published June 6, 2016
2. Kowalski AE, Huber TR, Ni TW, Hartje LF, Appel KL, Yost JW, Ackerson CJ, Snow CD
Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin.
1. Oncogene - published June 6, 2016
2. Elf S, Lin R, Xia S, Pan Y, Shan C, Wu S, Lonial S, Gaddh M, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Boggon TJ, Fan J, Chen J
Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer.
1. Nat Microbiol - published June 6, 2016
2. Kabanova A, Marcandalli J, Zhou T, Bianchi S, Baxa U, Tsybovsky Y, Lilleri D, Silacci-Fregni C, Foglierini M, Fernandez-Rodriguez BM, Druz A, Zhang B, Geiger R, Pagani M, Sallusto F, Kwong PD, Corti D, Lanzavecchia A, Perez L
Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS-p110 crosstalk.
1. Nat Commun - published June 4, 2016
2. Tamaskovic R, Schwill M, Nagy-Davidescu G, Jost C, Schaefer DC, Verdurmen WP, Schaefer JV, Honegger A, Plückthun A
Claws, Disorder, and Conformational Dynamics of the C-Terminal Region of Human Desmoplakin.
1. J Phys Chem B - published June 3, 2016
2. McAnany CE, Mura C
Predicting Allosteric Effects from Orthosteric Binding in Hsp90-Ligand Interactions: Implications for Fragment-Based Drug Design.
1. PLoS Comput. Biol. - published June 3, 2016
2. Chandramohan A, Krishnamurthy S, Larsson A, Nordlund P, Jansson A, Anand GS
DBSI Server: DNA Binding Site Identifier.
1. Bioinformatics - published June 3, 2016
2. Sukumar S, Zhu X, Ericksen SS, Mitchell JC
Fusion of the endoplasmic reticulum by membrane-bound GTPases.
1. Semin. Cell Dev. Biol. - published June 3, 2016
2. Hu J, Rapoport TA
An Overview of Helicobacter pylori VacA Toxin Biology.
1. Toxins (Basel) - published June 3, 2016
2. Foegeding NJ, Caston RR, McClain MS, Ohi MD, Cover TL
H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.
1. Nature - published June 3, 2016
2. Saredi G, Huang H, Hammond CM, Alabert C, Bekker-Jensen S, Forne I, Reverón-Gómez N, Foster BM, Mlejnkova L, Bartke T, Cejka P, Mailand N, Imhof A, Patel DJ, Groth A
Mechanisms of Bacterial Transcription Termination: All Good Things Must End.
1. Annu Rev Biochem - published June 2, 2016
2. Ray-Soni A, Bellecourt MJ, Landick R
Structure and Function of the Mitochondrial Ribosome.
1. Annu. Rev. Biochem. - published June 2, 2016
2. Greber BJ, Ban N
Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling.
1. Blood - published June 2, 2016
2. Le Gall SM, Szabo R, Lee M, Kirchhofer D, Craik CS, Bugge TH, Camerer E
Phosphorylation of spore coat proteins by a family of atypical protein kinases.
1. Proc Natl Acad Sci U S A - published June 2, 2016
2. Nguyen KB, Sreelatha A, Durrant ES, Lopez-Garrido J, Muszewska A, Dudkiewicz M, Grynberg M, Yee S, Pogliano K, Tomchick DR, Pawłowski K, Dixon JE, Tagliabracci VS
Programming Self-Assembly of DNA Origami Honeycomb Two-Dimensional Lattices and Plasmonic Metamaterials.
1. J Am Chem Soc - published June 2, 2016
2. Wang P, Gaitanaros S, Lee S, Bathe M, Shih WM, Ke Y
Designer nanoscale DNA assemblies programmed from the top down.
1. Science - published June 2, 2016
2. Veneziano R, Ratanalert S, Zhang K, Zhang F, Yan H, Chiu W, Bathe M
Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.
1. BMC Struct. Biol. - published June 2, 2016
2. Marcotte DJ, Liu Y, Little K, Jones JH, Powell NA, Wildes CP, Silvian LF, Chodaparambil JV
Diffraction Techniques in Structural Biology.
1. Curr Protoc Nucleic Acid Chem - published June 2, 2016
2. Egli M
XPA: A key scaffold for human nucleotide excision repair.
1. DNA Repair (Amst.) - published June 2, 2016
2. Sugitani N, Sivley RM, Perry KE, Capra JA, Chazin WJ
Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex.
1. Elife - published June 2, 2016
2. Choi UB, Zhao M, Zhang Y, Lai Y, Brunger AT
Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
1. Cell - published June 2, 2016
2. Brown NG, VanderLinden R, Watson ER, Weissmann F, Ordureau A, Wu KP, Zhang W, Yu S, Mercredi PY, Harrison JS, Davidson IF, Qiao R, Lu Y, Dube P, Brunner MR, Grace CRR, Miller DJ, Haselbach D, Jarvis MA, Yamaguchi M, Yanishevski D, Petzold G, Sidhu SS, Kuhlman B, Kirschner MW, Harper JW, Peters JM, Stark H, Schulman BA
The Biochemistry of O-GlcNAc Transferase: Which Functions Make It Essential in Mammalian Cells?
1. Annu. Rev. Biochem. - published June 2, 2016
2. Levine ZG, Walker S
Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase.
1. Science - published June 2, 2016
2. Verba KA, Wang RY, Arakawa A, Liu Y, Shirouzu M, Yokoyama S, Agard DA
Structure of γ-tubulin small complex based on a cryo-EM map, chemical cross-links, and a remotely related structure.
1. J Struct Biol - published June 1, 2016
2. Greenberg CH, Kollman J, Zelter A, Johnson R, MacCoss MJ, Davis TN, Agard DA, Sali A
Site-Specific Radiofluorination of Biomolecules with 8-[(18)F]-Fluorooctanoic Acid Catalyzed by Lipoic Acid Ligase.
1. ACS Chem Biol - published June 1, 2016
2. Drake CR, Sevillano N, Truillet C, Craik CS, VanBrocklin HF, Evans MJ
CRISPR-Cas gene-editing reveals RsmA and RsmC act through FlhDC to repress the SdhE flavinylation factor and control motility and prodigiosin production in Serratia.
1. Microbiology (Reading) - published June 1, 2016
2. Hampton HG, McNeil MB, Paterson TJ, Ney B, Williamson NR, Easingwood RA, Bostina M, Salmond GPC, Fineran PC
Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells.
1. Virology - published June 1, 2016
2. Clark KB, Hsiao HM, Bassit L, Crowe JE Jr, Schinazi RF, Perng GC, Villinger F
Deep sequencing and human antibody repertoire analysis.
1. Curr Opin Immunol - published June 1, 2016
2. Boyd SD, Crowe JE Jr
Revealing Higher Order Protein Structure Using Mass Spectrometry.
1. J Am Soc Mass Spectrom - published June 1, 2016
2. Chait BT, Cadene M, Olinares PD, Rout MP, Shi Y
Molecular Signatures of Membrane Protein Complexes Underlying Muscular Dystrophy.
1. Mol Cell Proteomics - published June 1, 2016
2. Turk R, Hsiao JJ, Smits MM, Ng BH, Pospisil TC, Jones KS, Campbell KP, Wright ME
Value of histopathology for predicting the post-operative complications of ileo-anal anastomosis (J-pouch) procedure in children with refractory ulcerative colitis.
1. Pathology - published June 1, 2016
2. El Demellawy D, El Hallani S, de Nanassy J, Lee JY, Chan E, Sullivan K, Bass J, Mack D, Nasr A
Trypsin pre-treatment corrects SRID over-estimation of immunologically active, pre-fusion HA caused by mixed immunoprecipitin rings.
1. Vaccine - published June 1, 2016
2. Wen Y, Palladino G, Xie Y, Ferrari A, Ma X, Han L, Dormitzer PR, Settembre EC
Synthesis of Chiral Piperazinones Using Amphoteric Aziridine Aldehyde Dimers and Functionalized Isocyanides.
1. J. Org. Chem. - published June 1, 2016
2. Heine NB, Kaldas SJ, Belding L, Shmatova O, Dudding T, Nenajdenko VG, Studer A, Yudin AK
Genome Sequence and Analysis of a Stress-Tolerant, Wild-Derived Strain of Saccharomyces cerevisiae Used in Biofuels Research.
1. G3 (Bethesda) - published June 1, 2016
2. McIlwain SJ, Peris D, Sardi M, Moskvin OV, Zhan F, Myers KS, Riley NM, Buzzell A, Parreiras LS, Ong IM, Landick R, Coon JJ, Gasch AP, Sato TK, Hittinger CT
Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger.
1. Nat Struct Mol Biol - published June 1, 2016
2. Liao J, Marinelli F, Lee C, Huang Y, Faraldo-Gómez JD, Jiang Y
Structures of Preferred Human IgV Genes-Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation.
1. J. Immunol. - published June 1, 2016
2. Bryson S, Thomson CA, Risnes LF, Dasgupta S, Smith K, Schrader JW, Pai EF
Quantifying Variability of Manual Annotation in Cryo-Electron Tomograms.
1. Microsc Microanal - published June 1, 2016
2. Hecksel CW, Darrow MC, Dai W, Galaz-Montoya JG, Chin JA, Mitchell PG, Chen S, Jakana J, Schmid MF, Chiu W
Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology.
1. J Gen Physiol - published June 1, 2016
2. Barthmes M, Liao J, Jiang Y, Brüggemann A, Wahl-Schott C
Viral hijacking of a replicative helicase loader and its implications for helicase loading control and phage replication.
1. Elife - published June 1, 2016
2. Hood IV, Berger JM
Identification of rogue datasets in serial crystallography.
1. J Appl Crystallogr - published June 1, 2016
2. Assmann G, Brehm W, Diederichs K
IOTA: integration optimization, triage and analysis tool for the processing of XFEL diffraction images.
1. J Appl Crystallogr - published June 1, 2016
2. Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Murray TD, Sauter NK, Berger JM, Weis WI, Brunger AT
Modeling truncated pixel values of faint reflections in MicroED images.
1. J Appl Crystallogr - published June 1, 2016
2. Hattne J, Shi D, de la Cruz MJ, Reyes FE, Gonen T
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
1. Nature - published June 1, 2016
2. Gao Y, Cao E, Julius D, Cheng Y
Phylogeny Reconstruction with Alignment-Free Method That Corrects for Horizontal Gene Transfer.
1. PLoS Comput Biol - published June 1, 2016
2. Bromberg R, Grishin NV, Otwinowski Z
Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding.
1. PLoS Pathog - published June 1, 2016
2. Sapparapu G, Czakó R, Alvarado G, Shanker S, Prasad BV, Atmar RL, Estes MK, Crowe JE Jr
Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer.
1. Sci Adv - published June 1, 2016
2. Singhal H, Greene ME, Tarulli G, Zarnke AL, Bourgo RJ, Laine M, Chang YF, Ma S, Dembo AG, Raj GV, Hickey TE, Tilley WD, Greene GL