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131 Member Publications for October 2015

A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.
1. PLoS Pathog. - published October 31, 2015
2. Freund NT, Horwitz JA, Nogueira L, Sievers SA, Scharf L, Scheid JF, Gazumyan A, Liu C, Velinzon K, Goldenthal A, Sanders RW, Moore JP, Bjorkman PJ, Seaman MS, Walker BD, Klein F, Nussenzweig MC
Structure-enhanced methods in the development of non-nucleoside inhibitors targeting HIV reverse transcriptase variants.
1. Future Microbiol - published October 31, 2015
2. Frey KM
Non-classical amine recognition evolved in a large clade of olfactory receptors.
1. Elife - published October 31, 2015
2. Li Q, Tachie-Baffour Y, Liu Z, Baldwin MW, Kruse AC, Liberles SD
Two promising future developments of cryo-EM: capturing short-lived states and mapping a continuum of states of a macromolecule.
1. Microscopy (Oxf) - published October 31, 2015
2. Chen B, Frank J
Solution Structural Studies of GTP:Adenosylcobinamide-Phosphateguanylyl Transferase (CobY) from Methanocaldococcus jannaschii.
1. PLoS ONE - published October 30, 2015
2. Singarapu KK, Otte MM, Tonelli M, Westler WM, Escalante-Semerena JC, Markley JL
The nucleotide-dependent interaction of FlaH and FlaI is essential for assembly and function of the archaellum motor.
1. Mol. Microbiol. - published October 29, 2015
2. Chaudhury P, Neiner T, D'Imprima E, Banerjee A, Reindl S, Ghosh A, Arvai AS, Mills DJ, van der Does C, Tainer JA, Vonck J, Albers SV
Exposing Hidden Alternative Backbone Conformations in X-ray Crystallography Using qFit.
1. PLoS Comput. Biol. - published October 28, 2015
2. Keedy DA, Fraser JS, van den Bedem H
Structural Refinement of Proteins by Restrained Molecular Dynamics Simulations with Non-interacting Molecular Fragments.
1. PLoS Comput. Biol. - published October 28, 2015
2. Shen R, Han W, Fiorin G, Islam SM, Schulten K, Roux B
Hsp90-Cdc37 complexes with protein kinases form cooperatively with multiple distinct interaction sites.
1. J. Biol. Chem. - published October 28, 2015
2. Eckl JM, Scherr MJ, Freiburger L, Daake MA, Sattler M, Richter K
Regulation of sister chromatid cohesion during the mitotic cell cycle.
1. Sci China Life Sci - published October 28, 2015
2. Zheng G, Yu H
HIV-1 Adapts to Replicate in Cells Expressing Common Marmoset APOBEC3G and BST2.
1. J. Virol. - published October 28, 2015
2. Fernández-Oliva A, Finzi A, Haim H, Menéndez-Arias L, Sodroski J, Pacheco B
Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex.
1. EMBO J. - published October 28, 2015
2. Lye MF, Sharma M, El Omari K, Filman DJ, Schuermann JP, Hogle JM, Coen DM
Structural basis of membrane budding by the nuclear egress complex of herpesviruses.
1. EMBO J. - published October 28, 2015
2. Bigalke JM, Heldwein EE
Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration.
1. Proc. Natl. Acad. Sci. U.S.A. - published October 27, 2015
2. Lee S, Greenlee EB, Amick JR, Ligon GF, Lillquist JS, Natoli EJ, Hadari Y, Alvarado D, Schlessinger J
Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR.
1. J. Biomol. NMR - published October 27, 2015
2. Takeuchi K, Arthanari H, Shimada I, Wagner G
Brucella abortus Cell Cycle and Infection Are Coordinated.
1. Trends Microbiol. - published October 27, 2015
2. De Bolle X, Crosson S, Matroule JY, Letesson JJ
Crystal structure of group II intron domain 1 reveals a template for RNA assembly.
1. Nat. Chem. Biol. - published October 26, 2015
2. Zhao C, Rajashankar KR, Marcia M, Pyle AM
Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.
1. Nature - published October 26, 2015
2. Hengrung N, El Omari K, Serna Martin I, Vreede FT, Cusack S, Rambo RP, Vonrhein C, Bricogne G, Stuart DI, Grimes JM, Fodor E
Second messenger - Sensing riboswitches in bacteria.
1. Semin. Cell Dev. Biol. - published October 24, 2015
2. Ramesh A
Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.
1. Biochim. Biophys. Acta - published October 24, 2015
2. Yu X, Nandekar P, Mustafa G, Cojocaru V, Lepesheva GI, Wade RC
CacyBP/SIP--Structure and variety of functions.
1. Biochim. Biophys. Acta - published October 24, 2015
2. Topolska-Woś AM, Chazin WJ, Filipek A
Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping.
1. Nat Protoc - published October 23, 2015
2. Treweek JB, Chan KY, Flytzanis NC, Yang B, Deverman BE, Greenbaum A, Lignell A, Xiao C, Cai L, Ladinsky MS, Bjorkman PJ, Fowlkes CC, Gradinaru V
Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange.
1. Nat Protoc - published October 23, 2015
2. Hmelo LR, Borlee BR, Almblad H, Love ME, Randall TE, Tseng BS, Lin C, Irie Y, Storek KM, Yang JJ, Siehnel RJ, Howell PL, Singh PK, Tolker-Nielsen T, Parsek MR, Schweizer HP, Harrison JJ
Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury.
1. Redox Biol - published October 23, 2015
2. Jang S, Yu LR, Abdelmegeed MA, Gao Y, Banerjee A, Song BJ
The Potential Role of Solvation in Antibody Recognition of the Lewis Y Antigen.
1. Monoclon Antib Immunodiagn Immunother - published October 23, 2015
2. Saha S, Murali R, Pashov A, Kieber-Emmons T
HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons.
1. Science - published October 23, 2015
2. Shen QT, Ren X, Zhang R, Lee IH, Hurley JH
Molecular logic of neuronal self-recognition through protocadherin domain interactions.
1. Cell - published October 22, 2015
2. Rubinstein R, Thu CA, Goodman KM, Wolcott HN, Bahna F, Mannepalli S, Ahlsen G, Chevee M, Halim A, Clausen H, Maniatis T, Shapiro L, Honig B
Evolving new protein-protein interaction specificity through promiscuous intermediates.
1. Cell - published October 22, 2015
2. Aakre CD, Herrou J, Phung TN, Perchuk BS, Crosson S, Laub MT
Acinetobacter baumannii Repeatedly Evolves a Hypermutator Phenotype in Response to Tigecycline That Effectively Surveys Evolutionary Trajectories to Resistance.
1. PLoS ONE - published October 22, 2015
2. Hammerstrom TG, Beabout K, Clements TP, Saxer G, Shamoo Y
Comparative RNA seq analysis of the New Zealand glowworm Arachnocampa luminosa reveals bioluminescence-related genes.
1. BMC Genomics - published October 22, 2015
2. Sharpe ML, Dearden PK, Gimenez G, Krause KL
Dna2 nuclease-helicase structure, mechanism and regulation by Rpa.
1. Elife - published October 22, 2015
2. Zhou C, Pourmal S, Pavletich NP
Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity.
1. Cell - published October 22, 2015
2. Swanson MD, Boudreaux DM, Salmon L, Chugh J, Winter HC, Meagher JL, André S, Murphy PV, Oscarson S, Roy R, King S, Kaplan MH, Goldstein IJ, Tarbet EB, Hurst BL, Smee DF, de la Fuente C, Hoffmann HH, Xue Y, Rice CM, Schols D, Garcia JV, Stuckey JA, Gabius HJ, Al-Hashimi HM, Markovitz DM
Computational Tools To Model Halogen Bonds in Medicinal Chemistry.
1. J. Med. Chem. - published October 21, 2015
2. Ford MC, Ho PS
Deciphering the human immunome.
1. Expert Rev Vaccines - published October 21, 2015
2. Crowe JE Jr, Koff WC
Crystal Structure of the Human Cytomegalovirus Glycoprotein B.
1. PLoS Pathog. - published October 21, 2015
2. Burke HG, Heldwein EE
Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies.
1. PLoS Pathog. - published October 21, 2015
2. Ciferri C, Chandramouli S, Leitner A, Donnarumma D, Cianfrocco MA, Gerrein R, Friedrich K, Aggarwal Y, Palladino G, Aebersold R, Norais N, Settembre EC, Carfi A
Activation and lysis of human CD4 cells latently infected with HIV-1.
1. Nat Commun - published October 21, 2015
2. Pegu A, Asokan M, Wu L, Wang K, Hataye J, Casazza JP, Guo X, Shi W, Georgiev I, Zhou T, Chen X, O'Dell S, Todd JP, Kwong PD, Rao SS, Yang ZY, Koup RA, Mascola JR, Nabel GJ
The cerebral cavernous malformations proteins.
1. Oncotarget - published October 20, 2015
2. Li X, Fisher OS, Boggon TJ
Endocytosis of ligand activated sphingosine 1-phosphate receptor 1 mediated by the clathrin-pathway.
1. Traffic - published October 20, 2015
2. Reeves PM, Kang YL, Kirchhausen T
Reconstitution of the receptor-binding motif of the SARS coronavirus.
1. Protein Eng. Des. Sel. - published October 20, 2015
2. Freund NT, Roitburd-Berman A, Sui J, Marasco WA, Gershoni JM
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
1. Nat. Cell Biol. - published October 19, 2015
2. Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J
Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome biogenesis.
1. Nat. Struct. Mol. Biol. - published October 19, 2015
2. Chaker-Margot M, Hunziker M, Barandun J, Dill BD, Klinge S
PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
1. Nat. Immunol. - published October 19, 2015
2. Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, Lawson TG, Omattage NS, Brett TJ, Holtzman MJ
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.
1. Cancer Discov - published October 19, 2015
2. Seashore-Ludlow B, Rees MG, Cheah JH, Cokol M, Price EV, Coletti ME, Jones V, Bodycombe NE, Soule CK, Gould J, Alexander B, Li A, Montgomery P, Wawer MJ, Kuru N, Kotz JD, Hon CS, Munoz B, Liefeld T, Dančík V, Bittker JA, Palmer M, Bradner JE, Shamji AF, Clemons PA, Schreiber SL
Structure of an RNA polymerase II preinitiation complex.
1. Proc. Natl. Acad. Sci. U.S.A. - published October 19, 2015
2. Murakami K, Tsai KL, Kalisman N, Bushnell DA, Asturias FJ, Kornberg RD
Identification of the PhoB regulon and role of PhoU in the phosphate-starvation response of Caulobacter crescentus.
1. J. Bacteriol. - published October 19, 2015
2. Lubin EA, Henry JT, Fiebig A, Crosson S, Laub MT
BCL::Conf: small molecule conformational sampling using a knowledge based rotamer library.
1. J Cheminform - published October 17, 2015
2. Kothiwale S, Mendenhall JL, Meiler J
Structures of the double-ring AAA ATPase Pex1/Pex6 involved in peroxisome biogenesis.
1. FEBS J. - published October 17, 2015
2. Tan D, Blok NB, Rapoport TA, Walz T
The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.
1. PLoS Biol. - published October 16, 2015
2. Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, Zhang Y, Yates Iii JR, Itkin-Ansari P, Volkmann N, Kaufman RJ
Effect of European Chafer Larvae (Coleoptera: Scarabaeidae) on Winter Wheat and Role of Neonicotinoid Seed Treatments in Their Management.
1. J. Econ. Entomol. - published October 16, 2015
2. Renkema JM, Difonzo CD, Smith JL, Schaafsma AW
A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class.
1. Angew. Chem. Int. Ed. Engl. - published October 16, 2015
2. Košutić M, Neuner S, Ren A, Flür S, Wunderlich C, Mairhofer E, Vušurović N, Seikowski J, Breuker K, Höbartner C, Patel DJ, Kreutz C, Micura R
Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2.
1. Science - published October 16, 2015
2. Jiao L, Liu X
An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin.
1. Elife - published October 16, 2015
2. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC
Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.
1. Mol. Cell - published October 15, 2015
2. Lin Y, Protter DS, Rosen MK, Parker R
The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.
1. Mol. Cell - published October 15, 2015
2. Chen S, Yang Z, Wilkinson AW, Deshpande AJ, Sidoli S, Krajewski K, Strahl BD, Garcia BA, Armstrong SA, Patel DJ, Gozani O
FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs.
1. Mol. Cell - published October 15, 2015
2. Kemble DJ, McCullough LL, Whitby FG, Formosa T, Hill CP
Genetic characterization and improved genotyping of the dysferlin-deficient mouse strain Dysf (tm1Kcam).
1. Skelet Muscle - published October 15, 2015
2. Wiktorowicz T, Kinter J, Kobuke K, Campbell KP, Sinnreich M
Single-particle electron microscopy in the study of membrane protein structure.
1. Microscopy (Oxf) - published October 15, 2015
2. De Zorzi R, Mi W, Liao M, Walz T
Characterization and quantification of proteins secreted by single human embryos prior to implantation.
1. EMBO Mol Med - published October 15, 2015
2. Poli M, Ori A, Child T, Jaroudi S, Spath K, Beck M, Wells D
The right place at the right time: chaperoning core histone variants.
1. EMBO Rep. - published October 14, 2015
2. Mattiroli F, D'Arcy S, Luger K
An RNA Hybridization Assay for Screening Influenza A Virus Polymerase Inhibitors Using the Entire Ribonucleoprotein Complex.
1. Assay Drug Dev Technol - published October 14, 2015
2. Roch FF, Hinterkörner G, Menke J, Tang GQ, Cusack S, Butzendobler B, Buschmann H, Datta K, Wolkerstorfer A
Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface.
1. J. Struct. Biol. - published October 14, 2015
2. Zhang R, Li X, Boggon TJ
Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells.
1. J Mol Cell Biol - published October 14, 2015
2. Morozumi Y, Boussouar F, Tan M, Chaikuad A, Jamshidikia M, Colak G, He H, Nie L, Petosa C, de Dieuleveult M, Curtet S, Vitte AL, Rabatel C, Debernardi A, Cosset FL, Verhoeyen E, Emadali A, Schweifer N, Gianni D, Gut M, Guardiola P, Rousseaux S, Gérard M, Knapp S, Zhao Y, Khochbin S
Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus.
1. J. Bacteriol. - published October 14, 2015
2. Pratt AJ, DiDonato M, Shin DS, Cabelli DE, Bruns CK, Belzer CA, Gorringe AR, Langford PR, Tabatabai LB, Kroll JS, Tainer JA, Getzoff ED
Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera.
1. Sci Transl Med - published October 14, 2015
2. Ngwuta JO, Chen M, Modjarrad K, Joyce MG, Kanekiyo M, Kumar A, Yassine HM, Moin SM, Killikelly AM, Chuang GY, Druz A, Georgiev IS, Rundlet EJ, Sastry M, Stewart-Jones GB, Yang Y, Zhang B, Nason MC, Capella C, Peeples ME, Ledgerwood JE, McLellan JS, Kwong PD, Graham BS
A new member of the V1V2-directed CAP256-VRC26 lineage that shows increased breadth and exceptional potency.
1. J. Virol. - published October 14, 2015
2. Doria-Rose NA, Bhiman JN, Roark RS, Schramm CA, Gorman J, Chuang GY, Pancera M, Cale EM, Ernandes MJ, Louder MK, Asokan M, Bailer RT, Druz A, Fraschilla IR, Garrett NJ, Jarosinski M, Lynch RM, McKee K, O'Dell S, Pegu A, Schmidt SD, Staupe RP, Sutton MS, Wang K, Wibmer CK, Haynes BF, Abdool-Karim S, Shapiro L, Kwong PD, Moore PL, Morris L, Mascola JR
Nicotinamide mononucleotide adenylyltransferase displays alternate binding modes for nicotinamide nucleotides.
1. Acta Crystallogr. D Biol. Crystallogr. - published October 13, 2015
2. Pfoh R, Pai EF, Saridakis V
A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions.
1. Acta Crystallogr. D Biol. Crystallogr. - published October 13, 2015
2. Murray TD, Lyubimov AY, Ogata CM, Vo H, Uervirojnangkoorn M, Brunger AT, Berger JM
Inhibition of APOBEC3G Activity Impedes Double-Strand DNA Repair.
1. FEBS J. - published October 13, 2015
2. Prabhu P, Shandilya SM, Britan-Rosich E, Nagler A, Schiffer CA, Kotler M
Trimodal Therapy: Combining Hyperthermia with Repurposed Bexarotene and Ultrasound for Treating Liver Cancer.
1. ACS Nano - published October 12, 2015
2. Misra SK, Ghoshal G, Gartia MR, Wu Z, De AK, Ye M, Bromfield CR, Williams EM, Singh K, Tangella KV, Rund L, Schulten K, Schook LB, Ray PS, Burdette EC, Pan D
Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies.
1. Nat. Med. - published October 12, 2015
2. Bhiman JN, Anthony C, Doria-Rose NA, Karimanzira O, Schramm CA, Khoza T, Kitchin D, Botha G, Gorman J, Garrett NJ, Abdool Karim SS, Shapiro L, Williamson C, Kwong PD, Mascola JR, Morris L, Moore PL
Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia.
1. Haematologica - published October 11, 2015
2. Bury L, Falcinelli E, Chiasserini D, Springer TA, Italiano JE, Gresele P
Structural biology of the import pathways of peroxisomal matrix proteins.
1. Biochim. Biophys. Acta - published October 10, 2015
2. Emmanouilidis L, Gopalswamy M, Passon DM, Wilmanns M, Sattler M
The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein.
1. J. Mol. Biol. - published October 9, 2015
2. Morgan CE, Meagher JL, Levengood JD, Delproposto J, Rollins C, Stuckey JA, Tolbert BS
Structural Insights into Nonspecific Binding of DNA by TrmBL2, an Archaeal Chromatin Protein.
1. J Mol Biol - published October 9, 2015
2. Ahmad MUD, Waege I, Hausner W, Thomm M, Boos W, Diederichs K, Welte W
Mis16 Independently Recognizes Histone H4 and the CENP-A(Cnp1)-Specific Chaperone Scm3sp.
1. J. Mol. Biol. - published October 9, 2015
2. An S, Kim H, Cho US
Getting to reproducible antibodies: the rationale for sequenced recombinant characterized reagents.
1. Protein Eng. Des. Sel. - published October 9, 2015
2. Bradbury AR, Plückthun A
GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase KRAS4B, Exposing the Effector Binding Site.
1. J. Biol. Chem. - published October 9, 2015
2. Lu S, Banerjee A, Jang H, Zhang J, Gaponenko V, Nussinov R
Glycine receptor mechanism elucidated by electron cryo-microscopy.
1. Nature - published October 8, 2015
2. Du J, Lü W, Wu S, Cheng Y, Gouaux E
Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis.
1. Cell - published October 8, 2015
2. Berchowitz LE, Kabachinski G, Walker MR, Carlile TM, Gilbert WV, Schwartz TU, Amon A
Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I.
1. MBio - published October 8, 2015
2. Xu J, Mercado-López X, Grier JT, Kim WK, Chun LF, Irvine EB, Del Toro Duany Y, Kell A, Hur S, Gale M, Raj A, López CB
General Stress Signaling in the Alphaproteobacteria.
1. Annu. Rev. Genet. - published October 8, 2015
2. Fiebig A, Herrou J, Willett J, Crosson S
Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance.
1. ACS Med Chem Lett - published October 8, 2015
2. Gray WT, Frey KM, Laskey SB, Mislak AC, Spasov KA, Lee WG, Bollini M, Siliciano RF, Jorgensen WL, Anderson KS
Probing Structural Dynamics and Topology of the KCNE1 Membrane Protein in Lipid Bilayers via Site-Directed Spin Labeling and Electron Paramagnetic Resonance Spectroscopy.
1. Biochemistry - published October 7, 2015
2. Sahu ID, Craig AF, Dunagan MM, Troxel KR, Zhang R, Meiberg AG, Harmon CN, McCarrick RM, Kroncke BM, Sanders CR, Lorigan GA
Bacterial amyloid formation: structural insights into curli biogensis.
1. Trends Microbiol. - published October 7, 2015
2. Van Gerven N, Klein RD, Hultgren SJ, Remaut H
Binding screen for cftr correctors finds new chemical matter and yields insights into cf therapeutic strategy.
1. Protein Sci. - published October 7, 2015
2. Hall JD, Wang H, Byrnes LJ, Shanker S, Wang K, Efremov IV, Chong PA, Forman-Kay JD, Aulabaugh AE
Bispecific antibodies targeting different epitopes on the HIV-1 envelope exhibit broad and potent neutralization.
1. J. Virol. - published October 7, 2015
2. Asokan M, Rudicell RS, Louder M, McKee K, O'Dell S, Stewart-Jones G, Wang K, Xu L, Chen X, Choe M, Chuang G, Georgiev IS, Joyce MG, Kirys T, Ko S, Pegu A, Shi W, Todd JP, Yang Z, Bailer RT, Rao S, Kwong PD, Nabel GJ, Mascola JR
Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex.
1. Structure - published October 6, 2015
2. Qi S, Kim do J, Stjepanovic G, Hurley JH
Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins.
1. PLoS ONE - published October 6, 2015
2. Zhong N, Loppnau P, Seitova A, Ravichandran M, Fenner M, Jain H, Bhattacharya A, Hutchinson A, Paduch M, Lu V, Olszewski M, Kossiakoff AA, Dowdell E, Koide A, Koide S, Huang H, Nadeem V, Sidhu SS, Greenblatt JF, Marcon E, Arrowsmith CH, Edwards AM, Gräslund S
Towards the molecular mechanism of the integration of peroxisomal membrane proteins.
1. Biochim. Biophys. Acta - published October 6, 2015
2. Giannopoulou EA, Emmanouilidis L, Sattler M, Dodt G, Wilmanns M
Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM.
1. Elife - published October 6, 2015
2. Zhou A, Rohou A, Schep DG, Bason JV, Montgomery MG, Walker JE, Grigorieff N, Rubinstein JL
Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus.
1. Nat. Rev. Microbiol. - published October 6, 2015
2. Messaoudi I, Amarasinghe GK, Basler CF
Resting state of the human proton channel dimer in a lipid bilayer.
1. Proc. Natl. Acad. Sci. U.S.A. - published October 6, 2015
2. Li Q, Shen R, Treger JS, Wanderling SS, Milewski W, Siwowska K, Bezanilla F, Perozo E
Kinesin-2 KIF3AC and KIF3AB Can Drive Long-Range Transport along Microtubules.
1. Biophys. J. - published October 6, 2015
2. Guzik-Lendrum S, Rank KC, Bensel BM, Taylor KC, Rayment I, Gilbert SP
Conformationally selective biophysical assay for influenza vaccine potency determination.
1. Vaccine - published October 5, 2015
2. Wen Y, Han L, Palladino G, Ferrari A, Xie Y, Carfi A, Dormitzer PR, Settembre EC
Lipopolysaccharide transport to the cell surface: periplasmic transport and assembly into the outer membrane.
1. Philos. Trans. R. Soc. Lond., B, Biol. Sci. - published October 5, 2015
2. May JM, Sherman DJ, Simpson BW, Ruiz N, Kahne D
Lipopolysaccharide transport to the cell surface: biosynthesis and extraction from the inner membrane.
1. Philos. Trans. R. Soc. Lond., B, Biol. Sci. - published October 5, 2015
2. Simpson BW, May JM, Sherman DJ, Kahne D, Ruiz N
Editorial overview: Protein design and evolution-new protein architectures, evolutionary fine-tuning and analysis.
1. Curr. Opin. Struct. Biol. - published October 5, 2015
2. Fleishman SJ, Plückthun A
Observing the overall rocking motion of a protein in a crystal.
1. Nat Commun - published October 5, 2015
2. Ma P, Xue Y, Coquelle N, Haller JD, Yuwen T, Ayala I, Mikhailovskii O, Willbold D, Colletier JP, Skrynnikov NR, Schanda P
Determinants of amyloid fibril degradation by the PDZ protease HTRA1.
1. Nat. Chem. Biol. - published October 5, 2015
2. Poepsel S, Sprengel A, Sacca B, Kaschani F, Kaiser M, Gatsogiannis C, Raunser S, Clausen T, Ehrmann M
Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel.
1. Nature - published October 5, 2015
2. Hite RK, Yuan P, Li Z, Hsuing Y, Walz T, MacKinnon R
PAK kinases mediate the phosphorylation of PREX2 to initiate feedback inhibition of Rac1.
1. J. Biol. Chem. - published October 5, 2015
2. Barrows D, Schoenfeld SM, Hodakoski C, Silkov A, Honig B, Couvillon A, Shymanets A, Nürnberg B, Asara JM, Parsons R
Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis.
1. J. Exp. Med. - published October 5, 2015
2. Viny AD, Ott CJ, Spitzer B, Rivas M, Meydan C, Papalexi E, Yelin D, Shank K, Reyes J, Chiu A, Romin Y, Boyko V, Thota S, Maciejewski JP, Melnick A, Bradner JE, Levine RL
Transcriptional regulators of GntR family in Streptomyces coelicolor A3(2): analysis in silico and in vivo of YtrA subfamily.
1. Folia Microbiol. (Praha) - published October 3, 2015
2. Tsypik O, Yushchuk O, Zaburannyi N, Flärdh K, Walker S, Fedorenko V, Ostash B
The cysteine dioxygenase homologue from Pseudomonas aeruginosa is a 3-mercaptopropionate dioxygenase.
1. J Biol Chem - published October 2, 2015
2. Tchesnokov EP, Fellner M, Siakkou E, Kleffmann T, Martin LW, Aloi S, Lamont IL, Wilbanks SM, Jameson GN
Architecture of the fungal nuclear pore inner ring complex.
1. Science - published October 2, 2015
2. Stuwe T, Bley CJ, Thierbach K, Petrovic S, Schilbach S, Mayo DJ, Perriches T, Rundlet EJ, Jeon YE, Collins LN, Huber FM, Lin DH, Paduch M, Koide A, Lu V, Fischer J, Hurt E, Koide S, Kossiakoff AA, Hoelz A
Thermodynamics of Rev-RNA interactions in HIV-1 Rev-RRE assembly.
1. Biochemistry - published October 2, 2015
2. Jayaraman B, Mavor D, Gross JD, Frankel AD
Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.
1. Cell - published October 2, 2015
2. Zetsche B, Gootenberg JS, Abudayyeh OO, Slaymaker IM, Makarova KS, Essletzbichler P, Volz SE, Joung J, van der Oost J, Regev A, Koonin EV, Zhang F
High-resolution structures of a heterochiral coiled coil.
1. Proc Natl Acad Sci U S A - published October 2, 2015
2. Mortenson DE, Steinkruger JD, Kreitler DF, Perroni DV, Sorenson GP, Huang L, Mittal R, Yun HG, Travis BR, Mahanthappa MK, Forest KT, Gellman SH
Biosynthesis of a Novel Glutamate Racemase Containing a Site-Specific 7-Hydroxycoumarin Amino Acid: Enzyme-Ligand Promiscuity Revealed at the Atomistic Level.
1. ACS Cent Sci - published October 2, 2015
2. Dean SF, Whalen KL, Spies MA
The secretory pathway kinases.
1. Biochim Biophys Acta - published October 1, 2015
2. Sreelatha A, Kinch LN, Tagliabracci VS
Facile electrochemical detection of botulinum neurotoxin type E using a two-step proteolytic cleavage.
1. Biosens Bioelectron - published October 1, 2015
2. Park S, Shin YM, Song JJ, Yang H
H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses.
1. Immunology - published October 1, 2015
2. Bidula S, Sexton DW, Yates M, Abdolrasouli A, Shah A, Wallis R, Reed A, Armstrong-James D, Schelenz S
RecF and RecR Play Critical Roles in the Homologous Recombination and Single-Strand Annealing Pathways of Mycobacteria.
1. J Bacteriol - published October 1, 2015
2. Gupta R, Shuman S, Glickman MS
Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth.
1. Mol Cancer Ther - published October 1, 2015
2. Zhao DY, Jacobs KM, Hallahan DE, Thotala D
Assessing and maximizing data quality in macromolecular crystallography.
1. Curr Opin Struct Biol - published October 1, 2015
2. Karplus PA, Diederichs K
Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents.
1. ACS Chem Biol - published October 1, 2015
2. Kincaid VA, London N, Wangkanont K, Wesener DA, Marcus SA, Héroux A, Nedyalkova L, Talaat AM, Forest KT, Shoichet BK, Kiessling LL
ESCRTs are everywhere.
1. EMBO J. - published October 1, 2015
2. Hurley JH
Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback.
1. Nat Struct Mol Biol - published October 1, 2015
2. Tamayo AG, Duong HA, Robles MS, Mann M, Weitz CJ
In situ structural analysis of the human nuclear pore complex.
1. Nature - published October 1, 2015
2. von Appen A, Kosinski J, Sparks L, Ori A, DiGuilio AL, Vollmer B, Mackmull MT, Banterle N, Parca L, Kastritis P, Buczak K, Mosalaganti S, Hagen W, Andres-Pons A, Lemke EA, Bork P, Antonin W, Glavy JS, Bui KH, Beck M
[Total cholesterol mediates the effect of ABO blood group on coronary heart disease].
1. Zhonghua Xin Xue Guan Bing Za Zhi - published October 1, 2015
2. Gong P, Li S, Hu L, Luo S, Li J, Jiang H
Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography.
1. Nat Commun - published October 1, 2015
2. Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS
SRSF1-Regulated Alternative Splicing in Breast Cancer.
1. Mol Cell - published October 1, 2015
2. Anczuków O, Akerman M, Cléry A, Wu J, Shen C, Shirole NH, Raimer A, Sun S, Jensen MA, Hua Y, Allain FH, Krainer AR
Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
1. Science - published October 1, 2015
2. Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, Shultz LD, Mempel TR, Bjorkman PJ, Kumar P, Mothes W
Dynamical features of the Plasmodium falciparum ribosome during translation.
1. Nucleic Acids Res. - published October 1, 2015
2. Sun M, Li W, Blomqvist K, Das S, Hashem Y, Dvorin JD, Frank J
Solute carriers keep on rockin'.
1. Nat Struct Mol Biol - published October 1, 2015
2. Reithmeier RA, Moraes TF
Crystallizing the 6S and 8S spliceosomal assembly intermediates: a complex project.
1. Acta Crystallogr D Biol Crystallogr - published October 1, 2015
2. Pelz JP, Schindelin H, van Pee K, Kuper J, Kisker C, Diederichs K, Fischer U, Grimm C
A new quaternary structure epitope on dengue virus serotype 2 is the target of durable type-specific neutralizing antibodies.
1. mBio - published October 1, 2015
2. Gallichotte EN, Widman DG, Yount BL, Wahala WM, Durbin A, Whitehead S, Sariol CA, Crowe JE Jr, de Silva AM, Baric RS
Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response.
1. PLoS Comput Biol - published October 1, 2015
2. van der Lee R, Feng Q, Langereis MA, Ter Horst R, Szklarczyk R, Netea MG, Andeweg AC, van Kuppeveld FJ, Huynen MA
Mechanistic investigation of aziridine aldehyde-driven peptide macrocyclization: the imidoanhydride pathway.
1. Chem Sci - published October 1, 2015
2. Zaretsky S, Hickey JL, Tan J, Pichugin D, St Denis MA, Ler S, Chung BKW, Scully CCG, Yudin AK
SCT Promoter Methylation is a Highly Discriminative Biomarker for Lung and Many Other Cancers.
1. IEEE Life Sci Lett - published October 1, 2015
2. Sathe A, Zhang YA, Ma X, Ray P, Cadinu D, Wang YW, Yao X, Liu X, Tang H, Wang Y, Huang Y, Liu C, Gu J, Akerman M, Mo Y, Cheng C, Xuan Z, Chen L, Xiao G, Xie Y, Girard L, Wang H, Lam S, Wistuba II, Zhang L, Gazdar AF, Zhang MQ