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161 Member Publications for October 2014

Crystal structure of human protein N-terminal glutamine amidohydrolase, an initial component of the N-end rule pathway.
1. PLoS ONE - published October 31, 2014
2. Park MS, Bitto E, Kim KR, Bingman CA, Miller MD, Kim HJ, Han BW, Phillips GN
Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force.
1. Science - published October 31, 2014
2. Buckley CD, Tan J, Anderson KL, Hanein D, Volkmann N, Weis WI, Nelson WJ, Dunn AR
RNA. Complete pairing not needed.
1. Science - published October 31, 2014
2. Patel DJ
Goniometer-based femtosecond crystallography with X-ray free electron lasers.
1. Proc. Natl. Acad. Sci. U.S.A. - published October 31, 2014
2. Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO
A liaR Deletion Restores Susceptibility to Daptomycin and Antimicrobial Peptides in Multidrug-Resistant Enterococcus faecalis.
1. J. Infect. Dis. - published October 31, 2014
2. Reyes J, Panesso D, Tran TT, Mishra NN, Cruz MR, Munita JM, Singh KV, Yeaman MR, Murray BE, Shamoo Y, Garsin D, Bayer AS, Arias CA
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
1. Nature - published October 30, 2014
2. Sackton KL, Dimova N, Zeng X, Tian W, Zhang M, Sackton TB, Meaders J, Pfaff KL, Sigoillot F, Yu H, Luo X, King RW
Structure of a cupin protein Plu4264 from Photorhabdus luminescens subsp. laumondii TTO1 at 1.35 Å resolution.
1. Proteins - published October 30, 2014
2. Weerth RS, Michalska K, Bingman CA, Yennamalli RM, Li H, Jedrzejczak R, Wang F, Babnigg G, Joachimiak A, Thomas MG, Phillips GN
Insight into the allosteric mechanism of Scapharca dimeric hemoglobin.
1. Biochemistry - published October 30, 2014
2. Laine JM, Amat M, Morgan BR, Royer WE, Massi F
Biosynthesis of 8-hydroxyquinoline-2-carboxylic acid, an iron chelator from the gut of the lepidopteran Spodoptera littoralis.
1. Org. Biomol. Chem. - published October 30, 2014
2. Pesek J, Svoboda J, Sattler M, Bartram S, Boland W
Structural basis for the de-N-acetylation of poly-β-1,6-N-acetyl-D-glucosamine in Gram-positive bacteria.
1. J. Biol. Chem. - published October 30, 2014
2. Little DJ, Bamford NC, Podrovskaya V, Robinson H, Nitz M, Howell PL
Cellular manganese content is developmentally regulated in human dopaminergic neurons.
1. Sci Rep - published October 29, 2014
2. Kumar KK, Lowe EW, Aboud AA, Neely MD, Redha R, Bauer JA, Odak M, Weaver CD, Meiler J, Aschner M, Bowman AB
Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease.
1. Proc. Natl. Acad. Sci. U.S.A. - published October 29, 2014
2. Ozen A, Lin KH, Kurt Yilmaz N, Schiffer CA
Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells.
1. Proc. Natl. Acad. Sci. U.S.A. - published October 28, 2014
2. Roy S, Ly D, Li NS, Altman JD, Piccirilli JA, Moody DB, Adams EJ
Loss of conformational entropy in protein folding calculated using realistic ensembles and its implications for NMR-based calculations.
1. Proc. Natl. Acad. Sci. U.S.A. - published October 28, 2014
2. Baxa MC, Haddadian EJ, Jumper JM, Freed KF, Sosnick TR
Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes.
1. Proc. Natl. Acad. Sci. U.S.A. - published October 28, 2014
2. Pratt AJ, Shin DS, Merz GE, Rambo RP, Lancaster WA, Dyer KN, Borbat PP, Poole FL, Adams MW, Freed JH, Crane BR, Tainer JA, Getzoff ED
Calsyntenin3: Molecular Architecture and Interaction with Neurexin 1alpha.
1. J. Biol. Chem. - published October 28, 2014
2. Lu Z, Wang Y, Chen F, Tong H, Reddy MV, Luo L, Seshadrinathan S, Zhang L, Holthauzen LM, Craig AM, Ren G, Rudenko G
Synthetic Antibody Fragment Targeting Nicastrin Affects Assembly and Trafficking of γ-Secretase.
1. J. Biol. Chem. - published October 28, 2014
2. Zhang X, Hoey R, Koide A, Dolios G, Paduch M, Nguyen P, Wu X, Li Y, Wagner SL, Wang R, Koide S, Sisodia SS
Crystal Structure of Tryptophan Lyase (NosL): Evidence for Radical Formation at the Amino Group of Tryptophan.
1. Angew. Chem. Int. Ed. Engl. - published October 27, 2014
2. Nicolet Y, Zeppieri L, Amara P, Fontecilla-Camps JC
Scaling laws governing stochastic growth and division of single bacterial cells.
1. Proc. Natl. Acad. Sci. U.S.A. - published October 27, 2014
2. Iyer-Biswas S, Wright CS, Henry JT, Lo K, Burov S, Lin Y, Crooks GE, Crosson S, Dinner AR, Scherer NF
Benchmarking all-atom simulations using hydrogen exchange.
1. Proc. Natl. Acad. Sci. U.S.A. - published October 27, 2014
2. Skinner JJ, Yu W, Gichana EK, Baxa MC, Hinshaw JR, Freed KF, Sosnick TR
Microfluidic isolation of cancer-cell-derived microvesicles from hetergeneous extracellular shed vesicle populations.
1. Biomed Microdevices - published October 25, 2014
2. Santana SM, Antonyak MA, Cerione RA, Kirby BJ
Current Perspectives on HIV-1 Antiretroviral Drug Resistance.
1. Viruses - published October 25, 2014
2. Iyidogan P, Anderson KS
A polyketide synthase acyltransferase domain structure suggests a recognition mechanism for its hydroxymalonyl-acyl carrier protein substrate.
1. PLoS One - published October 24, 2014
2. Park H, Kevany BM, Dyer DH, Thomas MG, Forest KT
GPU-accelerated analysis and visualization of large structures solved by molecular dynamics flexible fitting.
1. Faraday Discuss. - published October 24, 2014
2. Stone JE, McGreevy R, Isralewitz B, Schulten K
High thermodynamic stability of parametrically designed helical bundles.
1. Science - published October 24, 2014
2. Huang PS, Oberdorfer G, Xu C, Pei XY, Nannenga BL, Rogers JM, DiMaio F, Gonen T, Luisi B, Baker D
Characterization of the Grp94/OS-9 Chaperone-Lectin Complex.
1. J. Mol. Biol. - published October 23, 2014
2. Seidler PM, Shinsky SA, Hong F, Li Z, Cosgrove MS, Gewirth DT
Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors.
1. J. Med. Chem. - published October 23, 2014
2. Pantouris G, Rajasekaran D, Garcia AB, Ruiz VG, Leng L, Jorgensen WL, Bucala R, Lolis EJ
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
1. Nature - published October 23, 2014
2. Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD
A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).
1. J. Biol. Chem. - published October 23, 2014
2. Fahrner M, Muik M, Schindl R, Butorac C, Stathopulos P, Zheng L, Jardin I, Ikura M, Romanin C
Stereocontrolled Disruption of the Ugi Reaction toward the Production of Chiral Piperazinones: Substrate Scope and Process Development.
1. J. Org. Chem. - published October 22, 2014
2. Zaretsky S, Adachi S, Rotstein BH, Hickey JL, Scully CC, St Denis JD, Courtemanche R, Yu JC, Chung BK, Yudin AK
Detection of lipid-linked peptidoglycan precursors by exploiting an unexpected transpeptidase reaction.
1. J. Am. Chem. Soc. - published October 22, 2014
2. Qiao Y, Lebar MD, Schirner K, Schaefer K, Tsukamoto H, Kahne D, Walker S
Efficient Modification of Alpha-Synuclein Serine 129 by Protein Kinase CK1 Requires Phosphorylation of Tyrosine 125 as a Priming Event.
1. ACS Chem Neurosci - published October 22, 2014
2. Kosten J, Binolfi A, Stuiver M, Verzini S, Theillet FX, Bekei B, van Rossum M, Selenko P
Structure and insights into the function of a Ca(2+)-activated Cl(-) channel.
1. Nature - published October 22, 2014
2. Dickson VK, Pedi L, Long SB
Human Cytomegalovirus UL97 Phosphorylates the Viral Nuclear Egress Complex.
1. J. Virol. - published October 22, 2014
2. Sharma M, Bender BJ, Kamil JP, Lye MF, Pesola JM, Reim NI, Hogle JM, Coen DM
Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis.
1. Proc. Natl. Acad. Sci. U.S.A. - published October 22, 2014
2. Lohman DC, Forouhar F, Beebe ET, Stefely MS, Minogue CE, Ulbrich A, Stefely JA, Sukumar S, Luna-Sánchez M, Jochem A, Lew S, Seetharaman J, Xiao R, Wang H, Westphall MS, Wrobel RL, Everett JK, Mitchell JC, López LC, Coon JJ, Tong L, Pagliarini DJ
Human Translation Initiation Factor eIF4G1 Possesses a Low-Affinity ATP Binding Site Facing the ATP-Binding Cleft of eIF4A in the eIF4G/eIF4A Complex.
1. Biochemistry - published October 21, 2014
2. Akabayov SR, Akabayov B, Wagner G
Structural and Functional Insights into the N-Terminus of Schizosaccharomyces pombe Cdc5.
1. Biochemistry - published October 21, 2014
2. Collier SE, Voehler M, Peng D, Ohi R, Gould KL, Reiter NJ, Ohi MD
The Host Protein Calprotectin Modulates the Helicobacter pylori cag Type IV Secretion System via Zinc Sequestration.
1. PLoS Pathog. - published October 21, 2014
2. Gaddy JA, Radin JN, Loh JT, Piazuelo MB, Kehl-Fie TE, Delgado AG, Ilca FT, Peek RM, Cover TL, Chazin WJ, Skaar EP, Scott Algood HM
Functionally Important Carboxyls in a Bacterial Homologue of the Vesicular Monoamine Transporter (VMAT).
1. J. Biol. Chem. - published October 21, 2014
2. Yaffe D, Vergara-Jaque A, Shuster Y, Listov D, Meena S, Singh SK, Forrest LR, Schuldiner S
Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity.
1. Cancer Res. - published October 21, 2014
2. Kawasumi M, Bradner JE, Tolliday N, Thibodeau R, Sloan H, Brummond KM, Nghiem P
The Making of a Sweet Modification: Structure and Function of O-GlcNAc Transferase.
1. J. Biol. Chem. - published October 21, 2014
2. Janetzko J, Walker S
Protein modification by adenine propenal.
1. Chem. Res. Toxicol. - published October 20, 2014
2. Shuck SC, Wauchope OR, Rose KL, Kingsley PJ, Rouzer CA, Shell SM, Sugitani N, Chazin WJ, Zagol-Ikapitte I, Boutaud O, Oates JA, Galligan JJ, Beavers WN, Marnett LJ
A computational study on a strategy for isolating a stable cyclopentadienyl cation.
1. Chemistry - published October 20, 2014
2. Iversen KJ, Wilson DJ, Dutton JL
Major Groove Orientation of the (2S)-N(6)-(2-Hydroxy-3-buten-1-yl)-2'-deoxyadenosine DNA Adduct Induced by 1,2-Epoxy-3-butene.
1. Chem. Res. Toxicol. - published October 20, 2014
2. Kowal EA, Wickramaratne S, Kotapati S, Turo M, Tretyakova N, Stone MP
Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.
1. Nat. Struct. Mol. Biol. - published October 19, 2014
2. Ehrnstorfer IA, Geertsma ER, Pardon E, Steyaert J, Dutzler R
Biomolecular Halogen Bonds.
1. Top Curr Chem - published October 19, 2014
2. Ho PS
Pharmacological targeting of the pseudokinase Her3.
1. Nat. Chem. Biol. - published October 19, 2014
2. Xie T, Lim SM, Westover KD, Dodge ME, Ercan D, Ficarro SB, Udayakumar D, Gurbani D, Tae HS, Riddle SM, Sim T, Marto JA, Jänne PA, Crews CM, Gray NS
Prothrombin structure: unanticipated features and opportunities.
1. Expert Rev Proteomics - published October 18, 2014
2. Pozzi N, Di Cera E
Chemical Modulation of Mutant mGlu1 Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics.
1. ACS Chem. Biol. - published October 17, 2014
2. Cho HP, Garcia-Barrantes PM, Brogan JT, Hopkins CR, Niswender CM, Rodriguez AL, Venable DF, Morrison RD, Bubser M, Daniels JS, Jones CK, Conn PJ, Lindsley CW
Shifting the energy landscape of multicomponent reactions using aziridine aldehyde dimers: a mechanistic study.
1. J. Org. Chem. - published October 17, 2014
2. Belding L, Zaretsky S, Rotstein BH, Yudin AK, Dudding T
Effects of Bu-Shen-An-Tai recipe and its two components on endometrial morphology during peri-implantation in superovulated mice.
1. J. Huazhong Univ. Sci. Technol. Med. Sci. - published October 17, 2014
2. Cui DD, Zheng CH, Gong P, Wen L, Ma WW, Zhou SC, Zhang MM
Drugging the undruggable RAS: Mission Possible?
1. Nat Rev Drug Discov - published October 17, 2014
2. Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ
Electronic detection of dsDNA transition from helical to zipper conformation using graphene nanopores.
1. Nanotechnology - published October 17, 2014
2. Sathe C, Girdhar A, Leburton JP, Schulten K
New tools provide a second look at HDV ribozyme structure, dynamics and cleavage.
1. Nucleic Acids Res. - published October 17, 2014
2. Kapral GJ, Jain S, Noeske J, Doudna JA, Richardson DC, Richardson JS
Structural mechanism of glutamate receptor activation and desensitization.
1. Nature - published October 16, 2014
2. Meyerson JR, Kumar J, Chittori S, Rao P, Pierson J, Bartesaghi A, Mayer ML, Subramaniam S
Phase transitions of multivalent proteins can promote clustering of membrane receptors.
1. Elife - published October 16, 2014
2. Banjade S, Rosen MK
Cardiac Troponin I Pro82Ser Variant Induces Diastolic Dysfunction, Blunts β- Adrenergic Response and Impairs Myofilament Cooperativity.
1. J. Appl. Physiol. - published October 16, 2014
2. Ramirez-Correa GA, Frazier AH, Zhu G, Zhang P, Rappold T, Kooij V, Bedja D, Snyder GA, Lugo-Fagundo NS, Hariharan R, Li Y, Shen X, Gao WD, Cingolani OH, Takimoto E, Foster DB, Murphy AM
Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors.
1. Clin. Cancer Res. - published October 15, 2014
2. Wainwright DA, Chang AL, Dey M, Balyasnikova IV, Kim CK, Tobias A, Cheng Y, Kim JW, Qiao J, Zhang L, Han Y, Lesniak MS
Efficient initial volume determination from electron microscopy images of single particles.
1. Bioinformatics - published October 15, 2014
2. Vargas J, Alvarez-Cabrera AL, Marabini R, Carazo JM, Sorzano CO
Inhibition of Enterovirus 71 by Adenosine Analog NITD008.
1. J. Virol. - published October 15, 2014
2. Deng CL, Yeo H, Ye HQ, Liu SQ, Shang BD, Gong P, Alonso S, Shi PY, Zhang B
The Epstein-Barr Virus (EBV) Glycoprotein B Cytoplasmic C-Terminal Tail Domain Regulates the Energy Requirement for EBV-Induced Membrane Fusion.
1. J. Virol. - published October 15, 2014
2. Chen J, Zhang X, Jardetzky TS, Longnecker R
Probing the Functions of the Paramyxovirus Glycoproteins F and HN with a Panel of Synthetic Antibodies.
1. J. Virol. - published October 15, 2014
2. Welch BD, Paduch M, Leser GP, Bergman Z, Kors CA, Paterson RG, Jardetzky TS, Kossiakoff AA, Lamb RA
Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents.
1. ACS Chem Neurosci - published October 15, 2014
2. Bubser M, Bridges TM, Dencker D, Gould RW, Grannan M, Noetzel MJ, Lamsal A, Niswender CM, Daniels JS, Poslusney MS, Melancon BJ, Tarr JC, Byers FW, Wess J, Duggan ME, Dunlop J, Wood MW, Brandon NJ, Wood MR, Lindsley CW, Conn PJ, Jones CK
Counteracting suppression of CFTR and voltage-gated K(+) channels by a bacterial pathogenic factor with the natural product tannic acid.
1. Elife - published October 15, 2014
2. Ramu Y, Xu Y, Shin HG, Lu Z
Crystallographic studies of [NiFe]-hydrogenase mutants: towards consensus structures for the elusive unready oxidized states.
1. J. Biol. Inorg. Chem. - published October 15, 2014
2. Volbeda A, Martin L, Barbier E, Gutiérrez-Sanz O, De Lacey AL, Liebgott PP, Dementin S, Rousset M, Fontecilla-Camps JC
Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-dependent RNA Polymerases.
1. J. Virol. - published October 15, 2014
2. Campagnola G, McDonald S, Beaucourt S, Vignuzzi M, Peersen OB
Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase (HDAC) Inhibitors by Multimodality Molecular Imaging in Living Subjects.
1. Cancer Res. - published October 15, 2014
2. Chan CT, Qi J, Smith W, Paranol R, Mazitschek R, West N, Reeves R, Chiosis G, Schreiber SL, Bradner JE, Paulmurugan R, Gambhir SS
Perturbation in the conserved methyltransferase-polymerase interface of flavivirus NS5 differentially affects polymerase initiation and elongation.
1. J. Virol. - published October 15, 2014
2. Wu J, Lu G, Zhang B, Gong P
Characterization of Variants of the Pore-Forming Toxin ClyA from Escherichia coli Controlled by a Redox Switch.
1. Biochemistry - published October 14, 2014
2. Roderer D, Benke S, Müller M, Fäh-Rechsteiner H, Ban N, Schuler B, Glockshuber R
Pyrene-Based Quantitative Detection of the 5-Formylcytosine Loci Symmetry in the CpG Duplex Content during TET-Dependent Demethylation.
1. Angew. Chem. Int. Ed. Engl. - published October 13, 2014
2. Xu L, Chen YC, Chong J, Fin A, McCoy LS, Xu J, Zhang C, Wang D
TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer.
1. Cancer Cell - published October 13, 2014
2. Fayngerts SA, Wu J, Oxley CL, Liu X, Vourekas A, Cathopoulis T, Wang Z, Cui J, Liu S, Sun H, Lemmon MA, Zhang L, Shi Y, Chen YH
Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum.
1. Nature - published October 12, 2014
2. Li X, Roberti R, Blobel G
Investigating the ring expansion reaction of pentaphenylborole and an azide.
1. Chem. Commun. (Camb.) - published October 11, 2014
2. Couchman SA, Thompson TK, Wilson DJ, Dutton JL, Martin CD
Structure of catalase determined by MicroED.
1. Elife - published October 11, 2014
2. Nannenga BL, Shi D, Hattne J, Reyes FE, Gonen T
Design and characterization of structured protein linkers with differing flexibilities.
1. Protein Eng. Des. Sel. - published October 11, 2014
2. Klein JS, Jiang S, Galimidi RP, Keeffe JR, Bjorkman PJ
Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors.
1. Neuropharmacology - published October 11, 2014
2. Forman SA, Chiara DC, Miller KW
Evolutionarily conserved roles of the dicer helicase domain in regulating RNA interference processing.
1. J. Biol. Chem. - published October 10, 2014
2. Kidwell MA, Chan JM, Doudna JA
A Novel Protein-Protein Interaction in the RES (REtention and Splicing) Complex.
1. J. Biol. Chem. - published October 10, 2014
2. Tripsianes K, Friberg A, Barrandon C, Brooks M, van Tilbeurgh H, Seraphin B, Sattler M
Structure of urea transporters.
1. Subcell Biochem - published October 10, 2014
2. Levin EJ, Zhou M
STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel.
1. Nat Commun - published October 10, 2014
2. Gudlur A, Quintana A, Zhou Y, Hirve N, Mahapatra S, Hogan PG
Aromatic Anchor at an Invariant Hormone-Receptor Interface. FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.
1. J. Biol. Chem. - published October 10, 2014
2. Pandyarajan V, Smith BJ, Phillips NB, Whittaker L, Cox GP, Wickramasinghe N, Menting JG, Wan ZL, Whittaker J, Ismail-Beigi F, Lawrence MC, Weiss MA
Paired immunoglobulin-like receptor B regulates platelet activation.
1. Blood - published October 9, 2014
2. Fan X, Shi P, Dai J, Lu Y, Chen X, Liu X, Zhang K, Wu X, Sun Y, Wang K, Zhu L, Zhang CC, Zhang J, Chen GQ, Zheng J, Liu J
Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway.
1. Nature - published October 9, 2014
2. Faehnle CR, Walleshauser J, Joshua-Tor L
Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7.
1. ACS Chem Neurosci - published October 9, 2014
2. Jalan-Sakrikar N, Field JR, Klar R, Mattmann ME, Gregory KJ, Zamorano R, Engers DW, Bollinger SR, Weaver CD, Days EL, Lewis LM, Utley TJ, Hurtado M, Rigault D, Acher F, Walker AG, Melancon BJ, Wood MR, Lindsley CW, Conn PJ, Xiang Z, Hopkins CR, Niswender CM
Crystal structure of a eukaryotic group II intron lariat.
1. Nature - published October 9, 2014
2. Robart AR, Chan RT, Peters JK, Rajashankar KR, Toor N
CRISPR-Cas9 knockin mice for genome editing and cancer modeling.
1. Cell - published October 9, 2014
2. Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F
Constitutive phospholipid scramblase activity of a G protein-coupled receptor.
1. Nat Commun - published October 9, 2014
2. Goren MA, Morizumi T, Menon I, Joseph JS, Dittman JS, Cherezov V, Stevens RC, Ernst OP, Menon AK
Identification of the Major Prostaglandin Glycerol Ester Hydrolase in Human Cancer Cells.
1. J. Biol. Chem. - published October 9, 2014
2. Manna JD, Wepy JA, Hsu KL, Chang JW, Cravatt BF, Marnett LJ
Intrinsically disordered tubulin tails: complex tuners of microtubule functions?
1. Semin. Cell Dev. Biol. - published October 9, 2014
2. Roll-Mecak A
Pharmacoeconomics and the medicinal chemist.
1. ACS Med Chem Lett - published October 9, 2014
2. Lindsley CW
Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine.
1. Cell Host Microbe - published October 8, 2014
2. Williams BB, Van Benschoten AH, Cimermancic P, Donia MS, Zimmermann M, Taketani M, Ishihara A, Kashyap PC, Fraser JS, Fischbach MA
Proof of dual-topology architecture of Fluc F(-) channels with monobody blockers.
1. Nat Commun - published October 8, 2014
2. Stockbridge RB, Koide A, Miller C, Koide S
Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes.
1. Elife - published October 8, 2014
2. Chen L, Xu Y, Healer J, Thompson JK, Smith BJ, Lawrence MC, Cowman AF
Neutrophil-lymphocyte and platelet-lymphocyte ratios as prognostic factors following stereotactic radiation therapy for early-stage non-small cell lung cancer.
1. J Thorac Oncol - published October 8, 2014
2. Cannon NA, Meyer J, Iyengar P, Ahn C, Westover KD, Choy H, Timmerman R
Research at the Harvard Anesthesia Departments.
1. Anesthesiology - published October 8, 2014
2. Forman SA, Miller KW, Talmor D, Hickey P, Strichartz G, Wiener-Kronish J
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.
1. Science - published October 8, 2014
2. Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB, Kwong PD, Blanchard SC, Mothes W
Substrate-Specific Activation of the Mitotic Kinase Bub1 through Intramolecular Autophosphorylation and Kinetochore Targeting.
1. Structure - published October 8, 2014
2. Lin Z, Jia L, Tomchick DR, Luo X, Yu H
Promiscuous nickel import in human pathogens: structure, thermodynamics, and evolution of extracytoplasmic nickel-binding proteins.
1. Structure - published October 7, 2014
2. Lebrette H, Brochier-Armanet C, Zambelli B, de Reuse H, Borezée-Durant E, Ciurli S, Cavazza C
The Structure of a Conserved Piezo Channel Domain Reveals a Topologically Distinct β Sandwich Fold.
1. Structure - published October 7, 2014
2. Kamajaya A, Kaiser JT, Lee J, Reid M, Rees DC
Mass spec studio for integrative structural biology.
1. Structure - published October 7, 2014
2. Rey M, Sarpe V, Burns KM, Buse J, Baker CA, van Dijk M, Wordeman L, Bonvin AM, Schriemer DC
The Homology Model of PMP22 Suggests Mutations Resulting in Peripheral Neuropathy Disrupt Transmembrane Helix Packing.
1. Biochemistry - published October 7, 2014
2. Mittendorf KF, Kroncke BM, Meiler J, Sanders CR
Epigenetic dysregulation by nickel through repressive chromatin domain disruption.
1. Proc. Natl. Acad. Sci. U.S.A. - published October 7, 2014
2. Jose CC, Xu B, Jagannathan L, Trac C, Mallela RK, Hattori T, Lai D, Koide S, Schones DE, Cuddapah S
Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins.
1. Proc. Natl. Acad. Sci. U.S.A. - published October 7, 2014
2. Herzik MA, Jonnalagadda R, Kuriyan J, Marletta MA
Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery.
1. Drug Discov. Today - published October 7, 2014
2. Kothiwale S, Borza CM, Lowe W, Pozzi A, Meiler J
Phosphatidic acid modulation of Kv channel voltage sensor function.
1. Elife - published October 7, 2014
2. Hite RK, Butterwick JA, MacKinnon R
Copper-Based Pulsed Dipolar ESR Spectroscopy as a Probe of Protein Conformation Linked to Disease States.
1. Biophys. J. - published October 7, 2014
2. Merz GE, Borbat PP, Pratt AJ, Getzoff ED, Freed JH, Crane BR
Kinesin-12 Kif15 Targets Kinetochore Fibers through an Intrinsic Two-Step Mechanism.
1. Curr. Biol. - published October 6, 2014
2. Sturgill EG, Das DK, Takizawa Y, Shin Y, Collier SE, Ohi MD, Hwang W, Lang MJ, Ohi R
Crowning Proteins: Modulating the Protein Surface Properties using Crown Ethers.
1. Angew. Chem. Int. Ed. Engl. - published October 6, 2014
2. Lee CC, Maestre-Reyna M, Hsu KC, Wang HC, Liu CI, Jeng WY, Lin LL, Wood R, Chou CC, Yang JM, Wang AH
Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets.
1. Protein Sci. - published October 6, 2014
2. Clinton TR, Weinstock MT, Jacobsen MT, Szabo-Fresnais N, Pandya MJ, Whitby FG, Herbert AS, Prugar LI, McKinnon R, Hill CP, Welch BD, Dye JM, Eckert DM, Kay MS
Multiple Propofol-binding Sites in a γ-Aminobutyric Acid Type A Receptor (GABAAR) Identified Using a Photoreactive Propofol Analog.
1. J. Biol. Chem. - published October 3, 2014
2. Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB
Kinesin-2 KIF3AB Exhibits Novel ATPase Characteristics.
1. J. Biol. Chem. - published October 3, 2014
2. Albracht CD, Rank KC, Obrzut S, Rayment I, Gilbert SP
Global analysis of human nonreceptor tyrosine kinase specificity using high-density Peptide microarrays.
1. J. Proteome Res. - published October 3, 2014
2. Deng Y, Alicea-Velázquez NL, Bannwarth L, Lehtonen SI, Boggon TJ, Cheng HC, Hytönen VP, Turk BE
Therapeutic Strategies to Inhibit MYC.
1. Cold Spring Harb Perspect Med - published October 3, 2014
2. McKeown MR, Bradner JE
The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation.
1. Elife - published October 3, 2014
2. Willer T, Inamori K, Venzke D, Harvey C, Morgensen G, Hara Y, Beltrán Valero de Bernabé D, Yu L, Wright KM, Campbell KP
Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.
1. Science - published October 3, 2014
2. Theurillat JP, Udeshi ND, Errington WJ, Svinkina T, Baca SC, Pop M, Wild PJ, Blattner M, Groner AC, Rubin MA, Moch H, Privé GG, Carr SA, Garraway LA
Proteomics. Tracking cancer drugs in living cells by thermal profiling of the proteome.
1. Science - published October 3, 2014
2. Savitski MM, Reinhard FB, Franken H, Werner T, Savitski MF, Eberhard D, Martinez Molina D, Jafari R, Dovega RB, Klaeger S, Kuster B, Nordlund P, Bantscheff M, Drewes G
Construction of a quadruple auxotrophic mutant of an industrial polyploidy Saccharomyces cerevisiae using RNA-guided Cas9 nuclease.
1. Appl. Environ. Microbiol. - published October 3, 2014
2. Zhang GC, Kong II, Kim H, Liu JJ, Cate JH, Jin YS
Real-time observation of signal recognition particle binding to actively translating ribosomes.
1. Elife - published October 3, 2014
2. Noriega TR, Chen J, Walter P, Puglisi JD
A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.
1. J Mol Biol - published October 2, 2014
2. Boyken SE, Chopra N, Xie Q, Joseph RE, Wales TE, Fulton DB, Engen JR, Jernigan RL, Andreotti AH
The Protein Targeting Factor Get3 Functions as ATP-Independent Chaperone under Oxidative Stress Conditions.
1. Mol. Cell - published October 2, 2014
2. Voth W, Schick M, Gates S, Li S, Vilardi F, Gostimskaya I, Southworth DR, Schwappach B, Jakob U
Enhancer RNA Facilitates NELF Release from Immediate Early Genes.
1. Mol. Cell - published October 2, 2014
2. Schaukowitch K, Joo JY, Liu X, Watts JK, Martinez C, Kim TK
Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration.
1. J. Pharmacol. Exp. Ther. - published October 2, 2014
2. Tsugawa D, Oya Y, Masuzaki R, Ray K, Engers DW, Dib M, Do N, Kuramitsu K, Ho K, Frist A, Yu PB, Bloch KD, Lindsley CW, Hopkins CR, Hong CC, Karp SJ
Kruidenier et al. reply.
1. Nature - published October 2, 2014
2. Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM
Looking at LncRNAs with the Ribozyme Toolkit.
1. Mol. Cell - published October 2, 2014
2. Pyle AM
γδ T cell surveillance via CD1 molecules.
1. Trends Immunol. - published October 2, 2014
2. Luoma AM, Castro CD, Adams EJ
Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli.
1. mBio - published October 2, 2014
2. Greene SE, Pinkner JS, Chorell E, Dodson KW, Shaffer CL, Conover MS, Livny J, Hadjifrangiskou M, Almqvist F, Hultgren SJ
Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling.
1. Dev Cell - published October 2, 2014
2. Zhou Y, Nathans J
Validation and incremental value of the hybrid algorithm for CTO PCI.
1. Catheter Cardiovasc Interv - published October 1, 2014
2. Pershad A, Eddin M, Girotra S, Cotugno R, Daniels D, Lombardi W
Antimicrobial peptide resistance of Vibrio cholerae results from an LPS modification pathway related to nonribosomal peptide synthetases.
1. ACS Chem Biol - published October 1, 2014
2. Henderson JC, Fage CD, Cannon JR, Brodbelt JS, Keatinge-Clay AT, Trent MS
Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation.
1. J. Cell. Sci. - published October 1, 2014
2. Huet-Calderwood C, Brahme NN, Kumar N, Stiegler AL, Raghavan S, Boggon TJ, Calderwood DA
Induction and suppression of innate antiviral responses by picornaviruses.
1. Cytokine Growth Factor Rev - published October 1, 2014
2. Feng Q, Langereis MA, van Kuppeveld FJ
A double-hotdog with a new trick: structure and mechanism of the trans-acyltransferase polyketide synthase enoyl-isomerase.
1. ACS Chem Biol - published October 1, 2014
2. Gay DC, Spear PJ, Keatinge-Clay AT
CRISPR-mediated direct mutation of cancer genes in the mouse liver.
1. Nature - published October 1, 2014
2. Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T
Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of α-dystroglycan in cells and tissues.
1. J Biol Chem - published October 1, 2014
2. Inamori K, Willer T, Hara Y, Venzke D, Anderson ME, Clarke NF, Guicheney P, Bönnemann CG, Moore SA, Campbell KP
SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression.
1. Cancer Res - published October 1, 2014
2. Wang S, Sun W, Zhao Y, McEachern D, Meaux I, Barrière C, Stuckey JA, Meagher JL, Bai L, Liu L, Hoffman-Luca CG, Lu J, Shangary S, Yu S, Bernard D, Aguilar A, Dos-Santos O, Besret L, Guerif S, Pannier P, Gorge-Bernat D, Debussche L
HemR is an OmpR/PhoB-like response regulator from Leptospira, which simultaneously effects transcriptional activation and repression of key haem metabolism genes.
1. Mol Microbiol - published October 1, 2014
2. Morero NR, Botti H, Nitta KR, Carrión F, Obal G, Picardeau M, Buschiazzo A
Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors.
1. Org Biomol Chem - published October 1, 2014
2. He B, Hu J, Zhang X, Lin H
Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.
1. J Biol Chem - published October 1, 2014
2. Tang W, Strachan RT, Lefkowitz RJ, Rockman HA
Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354.
1. Bioorg. Med. Chem. Lett. - published October 1, 2014
2. Wen W, Young SE, Duvernay MT, Schulte ML, Nance KD, Melancon BJ, Engers J, Locuson CW, Wood MR, Daniels JS, Wu W, Lindsley CW, Hamm HE, Stauffer SR
The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation.
1. EMBO Mol Med - published October 1, 2014
2. Abot A, Fontaine C, Buscato M, Solinhac R, Flouriot G, Fabre A, Drougard A, Rajan S, Laine M, Milon A, Muller I, Henrion D, Adlanmerini M, Valéra MC, Gompel A, Gerard C, Péqueux C, Mestdagt M, Raymond-Letron I, Knauf C, Ferriere F, Valet P, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Lenfant F, Greene GL, Foidart JM, Arnal JF
Structural and mechanistic insights into poly(uridine) tract recognition by the hnRNP C RNA recognition motif.
1. J Am Chem Soc - published October 1, 2014
2. Cieniková Z, Damberger FF, Hall J, Allain FH, Maris C
The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain.
1. Nucleic Acids Res - published October 1, 2014
2. Rawling DC, Kohlway AS, Luo D, Ding SC, Pyle AM
Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4).
1. Nucleic Acids Res - published October 1, 2014
2. Thornton JE, Du P, Jing L, Sjekloca L, Lin S, Grossi E, Sliz P, Zon LI, Gregory RI
Identification of human TERT elements necessary for telomerase recruitment to telomeres.
1. Elife - published October 1, 2014
2. Schmidt JC, Dalby AB, Cech TR
The complete structure of the large subunit of the mammalian mitochondrial ribosome.
1. Nature - published October 1, 2014
2. Greber BJ, Boehringer D, Leibundgut M, Bieri P, Leitner A, Schmitz N, Aebersold R, Ban N
Delayed Ras/PKA signaling augments the unfolded protein response.
1. Proc Natl Acad Sci U S A - published October 1, 2014
2. Pincus D, Aranda-Díaz A, Zuleta IA, Walter P, El-Samad H
Dengue viruses are enhanced by distinct populations of serotype cross-reactive antibodies in human immune sera.
1. PLoS Pathog - published October 1, 2014
2. de Alwis R, Williams KL, Schmid MA, Lai CY, Patel B, Smith SA, Crowe JE, Wang WK, Harris E, de Silva AM
Evidence of a bacterial receptor for lysozyme: binding of lysozyme to the anti-σ factor RsiV controls activation of the ecf σ factor σV.
1. PLoS Genet - published October 1, 2014
2. Hastie JL, Williams KB, Sepúlveda C, Houtman JC, Forest KT, Ellermeier CD
Biochemical and biophysical characterization of the Selenium binding and reducing site in Arabidopsis thaliana homologue to mammals Selenium Binding Protein 1.
1. J. Biol. Chem. - published October 1, 2014
2. Schild F, Kieffer-Jaquinod S, Palencia A, Cobessi D, Sarret G, Zubieta C, Jourdain A, Dumas R, Forge V, Testemale D, Bourguignon J, Hugouvieux V
New methods for indexing multi-lattice diffraction data.
1. Acta Crystallogr D Biol Crystallogr - published October 1, 2014
2. Gildea RJ, Waterman DG, Parkhurst JM, Axford D, Sutton G, Stuart DI, Sauter NK, Evans G, Winter G
Use of massively multiple merged data for low-resolution S-SAD phasing and refinement of flavivirus NS1.
1. Acta Crystallogr D Biol Crystallogr - published October 1, 2014
2. Akey DL, Brown WC, Konwerski JR, Ogata CM, Smith JL
Crystallographic study of the phosphoethanolamine transferase EptC required for polymyxin resistance and motility in Campylobacter jejuni.
1. Acta Crystallogr D Biol Crystallogr - published October 1, 2014
2. Fage CD, Brown DB, Boll JM, Keatinge-Clay AT, Trent MS
Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
1. Acta Crystallogr. D Biol. Crystallogr. - published October 1, 2014
2. Qiu W, Lam R, Voytyuk O, Romanov V, Gordon R, Gebremeskel S, Vodsedalek J, Thompson C, Beletskaya I, Battaile KP, Pai EF, Rottapel R, Chirgadze NY
Expression, purification and preliminary crystallographic analysis of the cryptic polo-box domain of Caenorhabditis elegans ZYG-1.
1. Acta Crystallogr F Struct Biol Commun - published October 1, 2014
2. Shimanovskaya E, Dong G
Multi-crystal native SAD analysis at 6 keV.
1. Acta Crystallogr. D Biol. Crystallogr. - published October 1, 2014
2. Liu Q, Guo Y, Chang Y, Cai Z, Assur Z, Mancia F, Greene MI, Hendrickson WA
Response to On prompt update of literature references in the Protein Data Bank.
1. Acta Crystallogr. D Biol. Crystallogr. - published October 1, 2014
2. Berman HM, Burley SK, Kleywegt GJ, Nakamura H, Markley JL
Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance.
1. Development - published October 1, 2014
2. Hua ZL, Chang H, Wang Y, Smallwood PM, Nathans J
Cullin E3 ligases and their rewiring by viral factors.
1. Biomolecules - published October 1, 2014
2. Mahon C, Krogan NJ, Craik CS, Pick E
Isotropic actomyosin dynamics promote organization of the apical cell cortex in epithelial cells.
1. J Cell Biol - published October 1, 2014
2. Klingner C, Cherian AV, Fels J, Diesinger PM, Aufschnaiter R, Maghelli N, Keil T, Beck G, Tolić-Nørrelykke IM, Bathe M, Wedlich-Soldner R
Academia and industry: Companies on campus.
1. Nature - published October 1, 2014
2. Watson-Capps JJ, Cech TR
Committing the Oldest Sins in the Newest Kind of Ways-Antibodies Targeting the Influenza Virus Type A Hemagglutinin Globular Head.
1. Microbiol Spectr - published October 1, 2014
2. Krause JC, Crowe JE Jr