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136 Member Publications for September 2014

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane.
1. Proc. Natl. Acad. Sci. U.S.A. - published September 30, 2014
2. Westphal D, Dewson G, Menard M, Frederick P, Iyer S, Bartolo R, Gibson L, Czabotar PE, Smith BJ, Adams JM, Kluck RM
Structural Analysis of Asunaprevir Resistance in HCV NS3/4A Protease.
1. ACS Chem. Biol. - published September 30, 2014
2. Soumana DI, Ali A, Schiffer CA
Image Distortions of a Partially Fluorinated Hydrocarbon Molecule in Atomic Force Microscopy with Carbon Monoxide Terminated Tips.
1. Nano Lett. - published September 30, 2014
2. Moll N, Schuler B, Kawai S, Xu F, Peng L, Orita A, Otera J, Curioni A, Neu M, Repp J, Meyer G, Gross L
Structural Insights Into HLA-DM Mediated MHC II Peptide Exchange.
1. Curr Top Biochem Res - published September 30, 2014
2. Painter CA, Stern LJ
Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.
1. Elife - published September 30, 2014
2. Lew ED, Oh J, Burrola PG, Lax I, Zagórska A, Través PG, Schlessinger J, Lemke G
Four GTPases Differentially Regulate the Sec7 Arf-GEF to Direct Traffic at the trans-Golgi Network.
1. Dev. Cell - published September 29, 2014
2. McDonold CM, Fromme JC
Revisiting the NMR solution structure of the Cel48S type-I dockerin module from Clostridium thermocellum reveals a cohesin-primed conformation.
1. J. Struct. Biol. - published September 28, 2014
2. Chen C, Cui Z, Xiao Y, Cui Q, Smith SP, Lamed R, Bayer EA, Feng Y
Programmable RNA recognition and cleavage by CRISPR/Cas9.
1. Nature - published September 28, 2014
2. O'Connell MR, Oakes BL, Sternberg SH, East-Seletsky A, Kaplan M, Doudna JA
RIG-I self-oligomerization is either dispensable or very transient for signal transduction.
1. PLoS One - published September 27, 2014
2. Louber J, Kowalinski E, Bloyet LM, Brunel J, Cusack S, Gerlier D
Amyloid-β Peptide-specific DARPins as a Novel Class of Potential Therapeutics for Alzheimer Disease.
1. J. Biol. Chem. - published September 26, 2014
2. Hanenberg M, McAfoose J, Kulic L, Welt T, Wirth F, Parizek P, Strobel L, Cattepoel S, Späni C, Derungs R, Maier M, Plückthun A, Nitsch RM
The T4 Phage DNA Mimic Protein Arn Inhibits the DNA Binding Activity of the Bacterial Histone-like Protein H-NS.
1. J. Biol. Chem. - published September 26, 2014
2. Ho CH, Wang HC, Ko TP, Chang YC, Wang AH
Ligand binding to the FeMo-cofactor: structures of CO-bound and reactivated nitrogenase.
1. Science - published September 26, 2014
2. Spatzal T, Perez KA, Einsle O, Howard JB, Rees DC
The Brucella abortus virulence regulator, LovhK, is a sensor kinase in the general stress response signalling pathway.
1. Mol. Microbiol. - published September 26, 2014
2. Kim HS, Willett JW, Jain-Gupta N, Fiebig A, Crosson S
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease.
1. Nature - published September 25, 2014
2. Anders C, Niewoehner O, Duerst A, Jinek M
Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.
1. Cell Rep - published September 25, 2014
2. Gao P, Zillinger T, Wang W, Ascano M, Dai P, Hartmann G, Tuschl T, Deng L, Barchet W, Patel DJ
Structural basis for biomolecular recognition in overlapping binding sites in a diiron enzyme system.
1. Nat Commun - published September 25, 2014
2. Acheson JF, Bailey LJ, Elsen NL, Fox BG
Sequence co-evolution gives 3D contacts and structures of protein complexes.
1. Elife - published September 25, 2014
2. Hopf TA, Schärfe CP, Rodrigues JP, Green AG, Kohlbacher O, Sander C, Bonvin AM, Marks DS
Crystal structure of patatin-17 in complex with aged and non-aged organophosphorus compounds.
1. PLoS One - published September 24, 2014
2. Wijeyesakere SJ, Richardson RJ, Stuckey JA
Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB.
1. Elife - published September 24, 2014
2. Eicher T, Seeger MA, Anselmi C, Zhou W, Brandstätter L, Verrey F, Diederichs K, Faraldo-Gómez JD, Pos KM
Antimycobacterial activity of DNA intercalator inhibitors of Mycobacterium tuberculosis primase DnaG.
1. J. Antibiot. - published September 24, 2014
2. Gajadeera C, Willby MJ, Green KD, Shaul P, Fridman M, Garneau-Tsodikova S, Posey JE, Tsodikov OV
PARP1-driven Poly-ADP-ribosylation Regulates BRCA1 Function in Homologous Recombination Mediated DNA Repair.
1. Cancer Discov - published September 24, 2014
2. Hu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM
Hyperglycosylated stable core immunogens designed to present the CD4 binding site preferentially recognized by broadly neutralizing antibodies.
1. J. Virol. - published September 24, 2014
2. Ingale J, Tran K, Kong L, Dey B, McKee K, Schief W, Kwong PD, Mascola JR, Wyatt RT
Interactions Between Metal-Binding Domains Modulate Intracellular Targeting of Cu(I)-ATPase ATP7B, as Revealed by Nanobody Binding.
1. J. Biol. Chem. - published September 24, 2014
2. Huang Y, Nokhrin S, Hassanzadeh-Ghassabeh G, Yu CH, Yang H, Barry AN, Tonelli M, Markley JL, Muyldermans S, Dmitriev OY, Lutsenko S
NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis.
1. Mol. Cell - published September 24, 2014
2. Brown JD, Lin CY, Duan Q, Griffin G, Federation AJ, Paranal RM, Bair S, Newton G, Lichtman AH, Kung AL, Yang T, Wang H, Luscinskas FW, Croce KJ, Bradner JE, Plutzky J
Nanodisco Balls: Control over Surface versus Core Loading of Diagnostically Active Nanocrystals into Polymer Nanoparticles.
1. ACS Nano - published September 23, 2014
2. Chhour P, Gallo N, Cheheltani R, Williams D, Al-Zaki A, Paik T, Nichol JL, Tian Z, Naha PC, Witschey WR, Allcock HR, Murray CB, Tsourkas A, Cormode DP
Editorial overview: Membranes: Recent methods in the study of membrane protein structure.
1. Curr. Opin. Struct. Biol. - published September 23, 2014
2. Gonen T, Waksman G
Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases.
1. Trends Biochem. Sci. - published September 23, 2014
2. Endres NF, Barros T, Cantor AJ, Kuriyan J
Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding.
1. Elife - published September 23, 2014
2. Gelfand MV, Hagan N, Tata A, Oh WJ, Lacoste B, Kang KT, Kopycinska J, Bischoff J, Wang JH, Gu C
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.
1. J. Exp. Med. - published September 22, 2014
2. Shingai M, Donau OK, Plishka RJ, Buckler-White A, Mascola JR, Nabel GJ, Nason MC, Montefiori D, Moldt B, Poignard P, Diskin R, Bjorkman PJ, Eckhaus MA, Klein F, Mouquet H, Cetrulo Lorenzi JC, Gazumyan A, Burton DR, Nussenzweig MC, Martin MA, Nishimura Y
Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles.
1. Neuropsychopharmacology - published September 22, 2014
2. Rook JM, Tantawy MN, Ansari MS, Felts AS, Stauffer SR, Emmitte KA, Kessler RM, Niswender CM, Daniels JS, Jones CK, Lindsley CW, Conn PJ
Mutational Analysis of the Integral Membrane Methyltransferase Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Reveals Potential Substrate Binding Sites.
1. J. Biol. Chem. - published September 19, 2014
2. Diver MM, Long SB
Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the warburg effect.
1. J. Biol. Chem. - published September 19, 2014
2. Fan J, Kang HB, Shan C, Elf S, Lin R, Xie J, Gu TL, Aguiar M, Lonning S, Chung TW, Arellano M, Khoury HJ, Shin DM, Khuri FR, Boggon TJ, Kang S, Chen J
X-ray Crystal Structure of Teicoplanin A2-2 Bound to a Catalytic Peptide Sequence via the Carrier Protein Strategy.
1. J. Org. Chem. - published September 19, 2014
2. Han S, Le BV, Hajare HS, Baxter RH, Miller SJ
A Universal Approach to Prepare Reagents for DNA-Assisted Protein Analysis.
1. PLoS ONE - published September 19, 2014
2. Yan J, Gu GJ, Jost C, Hammond M, Plückthun A, Landegren U, Kamali-Moghaddam M
IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
1. Mol. Cell - published September 18, 2014
2. Ferrao R, Zhou H, Shan Y, Liu Q, Li Q, Shaw DE, Li X, Wu H
Structural Basis for the Oligomerization of the MADS Domain Transcription Factor SEPALLATA3 in Arabidopsis.
1. Plant Cell - published September 18, 2014
2. Puranik S, Acajjaoui S, Conn S, Costa L, Conn V, Vial A, Marcellin R, Melzer R, Brown E, Hart D, Theißen G, Silva CS, Parcy F, Dumas R, Nanao M, Zubieta C
Photochemistry of flavoprotein light sensors.
1. Nat. Chem. Biol. - published September 17, 2014
2. Conrad KS, Manahan CC, Crane BR
Drift of the HIV-1 envelope glycoprotein gp120 toward increased neutralization resistance over the course of the epidemic: a comprehensive study using the most potent and broadly neutralizing monoclonal antibodies.
1. J. Virol. - published September 17, 2014
2. Bouvin-Pley M, Morgand M, Meyer L, Goujard C, Moreau A, Mouquet H, Nussenzweig M, Pace C, Ho D, Bjorkman PJ, Baty D, Chames P, Pancera M, Kwong PD, Poignard P, Barin F, Braibant M
Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on SARS-Coronavirus Neutralization Escape and Fitness.
1. J. Virol. - published September 17, 2014
2. Sui J, Deming M, Rockx B, Liddington RC, Zhu QK, Baric RS, Marasco WA
Dynamin recruitment and membrane scission at the neck of a clathrin-coated pit.
1. Mol. Biol. Cell - published September 17, 2014
2. Cocucci E, Gaudin R, Kirchhausen T
The Conserved Disulfide Bond within Domain II (D-II) of Epstein-Barr Virus (EBV) gH has Divergent Roles in Membrane Fusion with Epithelial Cells and B Cells.
1. J. Virol. - published September 17, 2014
2. Möhl BS, Sathiyamoorthy K, Jardetzky TS, Longnecker R
Spectroscopic and computational investigation of iron(III) cysteine dioxygenase: implications for the nature of the putative superoxo-Fe(III) intermediate.
1. Biochemistry - published September 16, 2014
2. Blaesi EJ, Fox BG, Brunold TC
Single-molecule spectroscopy reveals chaperone-mediated expansion of substrate protein.
1. Proc. Natl. Acad. Sci. U.S.A. - published September 16, 2014
2. Kellner R, Hofmann H, Barducci A, Wunderlich B, Nettels D, Schuler B
Crystallographic Evidence of Drastic Conformational Changes in the Active Site of a Flavin-Dependent N-Hydroxylase.
1. Biochemistry - published September 16, 2014
2. Setser JW, Heemstra JR, Walsh CT, Drennan CL
Engineering and two-stage evolution of a lignocellulosic hydrolysate-tolerant Saccharomyces cerevisiae strain for anaerobic fermentation of xylose from AFEX pretreated corn stover.
1. PLoS One - published September 16, 2014
2. Parreiras LS, Breuer RJ, Avanasi Narasimhan R, Higbee AJ, La Reau A, Tremaine M, Qin L, Willis LB, Bice BD, Bonfert BL, Pinhancos RC, Balloon AJ, Uppugundla N, Liu T, Li C, Tanjore D, Ong IM, Li H, Pohlmann EL, Serate J, Withers ST, Simmons BA, Hodge DB, Westphall MS, Coon JJ, Dale BE, Balan V, Keating DH, Zhang Y, Landick R, Gasch AP, Sato TK
Dimerization-induced allostery in protein kinase regulation.
1. Trends Biochem. Sci. - published September 16, 2014
2. Lavoie H, Li JJ, Thevakumaran N, Therrien M, Sicheri F
Phosphorylation of Nox1 Regulates Association with NoxA1 Activation Domain.
1. Circ. Res. - published September 16, 2014
2. Streeter J, Schickling BM, Jiang S, Stanic B, Thiel WH, Gakhar L, Houtman JC, Miller FJ
Discovery of potent and selective GIRK1/2 modulators via 'molecular switches' within a series of 1-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)ureas.
1. Bioorg. Med. Chem. Lett. - published September 16, 2014
2. Wen W, Wu W, Weaver CD, Lindsley CW
In vivo analysis of formation and endocytosis of the Wnt/β-catenin signaling complex in zebrafish embryos.
1. J. Cell. Sci. - published September 15, 2014
2. Hagemann AI, Kurz J, Kauffeld S, Chen Q, Reeves PM, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S
2013 Philip S. Portoghese Medicinal Chemistry Lectureship: Drug Discovery Targeting Allosteric Sites.
1. J. Med. Chem. - published September 15, 2014
2. Lindsley CW
Structural analysis and modeling reveals new mechanisms governing ESCRT-III spiral filament assembly.
1. J. Cell Biol. - published September 15, 2014
2. Shen QT, Schuh AL, Zheng Y, Quinney K, Wang L, Hanna M, Mitchell JC, Otegui MS, Ahlquist P, Cui Q, Audhya A
Computerized quantification of ultrasonic heterogeneity in thyroid nodules.
1. Ultrasound Med Biol - published September 15, 2014
2. Chen KY, Chen CN, Wu MH, Ho MC, Tai HC, Kuo WH, Huang WC, Wang YH, Chen A, Chang KJ
Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation.
1. Nat. Genet. - published September 15, 2014
2. Romberg N, Al Moussawi K, Nelson-Williams C, Stiegler AL, Loring E, Choi M, Overton J, Meffre E, Khokha MK, Huttner AJ, West B, Podoltsev NA, Boggon TJ, Kazmierczak BI, Lifton RP
Binge alcohol promotes hypoxic liver injury through a CYP2E1-HIF-1α-dependent apoptosis pathway in mice and humans.
1. Free Radic. Biol. Med. - published September 15, 2014
2. Yun JW, Son MJ, Abdelmegeed MA, Banerjee A, Morgan TR, Yoo SH, Song BJ
Activation of the C-N bond of N-heterocyclic carbenes by inorganic elements.
1. Dalton Trans - published September 14, 2014
2. Iversen KJ, Wilson DJ, Dutton JL
Phospholipase D facilitates efficient entry of influenza virus, allowing escape from innate immune inhibition.
1. J. Biol. Chem. - published September 12, 2014
2. Oguin TH, Sharma S, Stuart AD, Duan S, Scott SA, Jones CK, Daniels JS, Lindsley CW, Thomas PG, Brown HA
Structure and substrate specificity of a eukaryotic fucosidase from Fusarium graminearum.
1. J. Biol. Chem. - published September 12, 2014
2. Cao H, Walton JD, Brumm P, Phillips GN
Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1.
1. Nat Commun - published September 12, 2014
2. Meiri D, Marshall CB, Mokady D, LaRose J, Mullin M, Gingras AC, Ikura M, Rottapel R
An inheritable variant of the innate immune receptor MDA5 promotes clearance of hepatitis C virus.
1. Hepatology - published September 12, 2014
2. Modis Y
Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition.
1. FEBS Lett. - published September 12, 2014
2. Cherkesova TS, Hargrove TY, Vanrell MC, Ges I, Usanov SA, Romano PS, Lepesheva GI
Insights into β2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3.
1. Protein Sci. - published September 12, 2014
2. Qi S, O'Hayre M, Gutkind JS, Hurley JH
New insights into the spatiotemporal localization of prothrombinase in vivo.
1. Blood - published September 11, 2014
2. Ivanciu L, Krishnaswamy S, Camire RM
Critical glycosylated residues in exon three of erythrocyte glycophorin a engage Plasmodium falciparum EBA-175 and define receptor specificity.
1. MBio - published September 11, 2014
2. Salinas ND, Paing MM, Tolia NH
NMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound states.
1. Biomol NMR Assign - published September 11, 2014
2. Takeuchi K, Sun ZY, Li S, Gal M, Wagner G
Key steps in ERAD of luminal ER proteins reconstituted with purified components.
1. Cell - published September 11, 2014
2. Stein A, Ruggiano A, Carvalho P, Rapoport TA
Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity.
1. ACS Med Chem Lett - published September 11, 2014
2. Berry CB, Bubser M, Jones CK, Hayes JP, Wepy JA, Locuson CW, Daniels JS, Lindsley CW, Hopkins CR
Discovery of a Highly Selective PLD2 Inhibitor (ML395): A New Probe with Improved Physiochemical Properties and Broad-Spectrum Antiviral Activity against Influenza Strains.
1. ChemMedChem - published September 10, 2014
2. O'Reilly MC, Oguin TH, Scott SA, Thomas PG, Locuson CW, Morrison RD, Daniels JS, Brown HA, Lindsley CW
Discovery and Characterization of 2-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a Potent and Selective Positive Allosteric Modulator of MrgX1.
1. ChemMedChem - published September 10, 2014
2. Wen W, Wang Y, Li Z, Tseng PY, McManus OB, Wu M, Li M, Lindsley CW, Dong X, Hopkins CR
Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies.
1. Cell Host Microbe - published September 10, 2014
2. Kepler TB, Liao HX, Alam SM, Bhaskarabhatla R, Zhang R, Yandava C, Stewart S, Anasti K, Kelsoe G, Parks R, Lloyd KE, Stolarchuk C, Pritchett J, Solomon E, Friberg E, Morris L, Karim SS, Cohen MS, Walter E, Moody MA, Wu X, Altae-Tran HR, Georgiev IS, Kwong PD, Boyd SD, Fire AZ, Mascola JR, Haynes BF
Structural characterization of anti-inflammatory immunoglobulin G Fc proteins.
1. J. Mol. Biol. - published September 9, 2014
2. Ahmed AA, Giddens J, Pincetic A, Lomino JV, Ravetch JV, Wang LX, Bjorkman PJ
The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant.
1. Proc. Natl. Acad. Sci. U.S.A. - published September 9, 2014
2. Wei Y, Funk MA, Rosado LA, Baek J, Drennan CL, Stubbe J
The association between 5-HTTLPR gene polymorphism and behavioral inhibition in Chinese toddlers.
1. Dev Psychobiol - published September 9, 2014
2. Chen X, Zhang G, Liang Z, Zhang M, Way N, Yoshikawa H, Ke X, Lu Z, Deng H
Deformable elastic network refinement for low-resolution macromolecular crystallography.
1. Acta Crystallogr. D Biol. Crystallogr. - published September 9, 2014
2. Schröder GF, Levitt M, Brunger AT
Allosteric inhibitors of calpains: Reevaluating inhibition by PD150606 and LSEAL.
1. Biochim. Biophys. Acta - published September 9, 2014
2. Low KE, Karunan Partha S, Davies PL, Campbell RL
xMDFF: molecular dynamics flexible fitting of low-resolution X-ray structures.
1. Acta Crystallogr. D Biol. Crystallogr. - published September 9, 2014
2. McGreevy R, Singharoy A, Li Q, Zhang J, Xu D, Perozo E, Schulten K
Use of miRNA Response Sequences to Block Off-target Replication and Increase the Safety of an Unattenuated, Glioblastoma-targeted Oncolytic HSV.
1. Mol. Ther. - published September 9, 2014
2. Mazzacurati L, Marzulli M, Reinhart B, Miyagawa Y, Uchida H, Goins WF, Li A, Kaur B, Caligiuri M, Cripe T, Chiocca N, Amankulor N, Cohen JB, Glorioso JC, Grandi P
Molecular mechanisms for contribution of MHC molecules to autoimmune diseases.
1. Curr. Opin. Immunol. - published September 9, 2014
2. Sollid LM, Pos W, Wucherpfennig KW
An ankyrin repeat domain of AKR2 drives chloroplast targeting through coincident binding of two chloroplast lipids.
1. Dev. Cell - published September 8, 2014
2. Kim DH, Park MJ, Gwon GH, Silkov A, Xu ZY, Yang EC, Song S, Song K, Kim Y, Yoon HS, Honig B, Cho W, Cho Y, Hwang I
Ena/VASP proteins cooperate with the WAVE complex to regulate the actin cytoskeleton.
1. Dev. Cell - published September 8, 2014
2. Chen XJ, Squarr AJ, Stephan R, Chen B, Higgins TE, Barry DJ, Martin MC, Rosen MK, Bogdan S, Way M
Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2.
1. Protein Sci. - published September 8, 2014
2. Ringel AE, Roman C, Wolberger C
Structural basis for membrane binding and remodeling by the exomer secretory vesicle cargo adaptor.
1. Dev. Cell - published September 8, 2014
2. Paczkowski JE, Fromme JC
A structure-based mechanism for tRNA and retroviral RNA remodelling during primer annealing.
1. Nature - published September 7, 2014
2. Miller SB, Yildiz FZ, Lo JA, Wang B, D'Souza VM
Structural basis for the assembly of the Sxl-Unr translation regulatory complex.
1. Nature - published September 7, 2014
2. Hennig J, Militti C, Popowicz GM, Wang I, Sonntag M, Geerlof A, Gabel F, Gebauer F, Sattler M
PONDEROSA-C/S: client-server based software package for automated protein 3D structure determination.
1. J. Biomol. NMR - published September 6, 2014
2. Lee W, Stark JL, Markley JL
The evolutionary journey of Argonaute proteins.
1. Nat. Struct. Mol. Biol. - published September 6, 2014
2. Swarts DC, Makarova K, Wang Y, Nakanishi K, Ketting RF, Koonin EV, Patel DJ, van der Oost J
Immunotherapy advances for glioblastoma.
1. Neuro-oncology - published September 6, 2014
2. Reardon DA, Freeman G, Wu C, Chiocca EA, Wucherpfennig KW, Wen PY, Fritsch EF, Curry WT, Sampson JH, Dranoff G
Influence of Pathogenic Mutations on the Energetics of Translocon-Mediated Bilayer Integration of Transmembrane Helices.
1. J. Membr. Biol. - published September 6, 2014
2. Schlebach JP, Sanders CR
Structural determinants for binding of sorting nexin 17 (SNX17) to the cytoplasmic adaptor protein Krev interaction trapped 1 (KRIT1).
1. J. Biol. Chem. - published September 5, 2014
2. Stiegler AL, Zhang R, Liu W, Boggon TJ
Chemical interrogation of the malaria kinome.
1. Chembiochem - published September 5, 2014
2. Derbyshire ER, Zuzarte-Luís V, Magalhães AD, Kato N, Sanschagrin PC, Wang J, Zhou W, Miduturu CV, Mazitschek R, Sliz P, Mota MM, Gray NS, Clardy J
Solid-phase synthesis of piperazinones via disrupted Ugi condensation.
1. Org. Lett. - published September 5, 2014
2. Treder AP, Tremblay MC, Yudin AK, Marsault E
Identifying the interaction of maternal sensitivity and two serotonin-related gene polymorphisms on infant self-regulation.
1. Infant Behav Dev - published September 5, 2014
2. Zhang M, Chen X, Deng H, Lu Z
Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP.
1. Elife - published September 4, 2014
2. Chatterjee D, Cooley RB, Boyd CD, Mehl RA, O'Toole GA, Sondermann H
Philip J. Fay (1953-2014).
1. J. Thromb. Haemost. - published September 4, 2014
2. Krishnaswamy S, Lollar P
Genes contributing to Staphylococcus aureus fitness in abscess- and infection-related ecologies.
1. MBio - published September 4, 2014
2. Valentino MD, Foulston L, Sadaka A, Kos VN, Villet RA, Santa Maria J, Lazinski DW, Camilli A, Walker S, Hooper DC, Gilmore MS
Stitched α-helical peptides via bis ring-closing metathesis.
1. J. Am. Chem. Soc. - published September 3, 2014
2. Hilinski GJ, Kim YW, Hong J, Kutchukian PS, Crenshaw CM, Berkovitch SS, Chang A, Ham S, Verdine GL
Facile formation of homoleptic Au(III) trications via simultaneous oxidation and ligand delivery from [PhI(pyridine)2](2+).
1. J. Am. Chem. Soc. - published September 3, 2014
2. Corbo R, Pell TP, Stringer BD, Hogan CF, Wilson DJ, Barnard PJ, Dutton JL
Development of a Highly Potent, Novel M5 Positive Allosteric Modulator (PAM) Demonstrating CNS Exposure: 1-((1H-Indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380).
1. J. Med. Chem. - published September 3, 2014
2. Gentry PR, Kokubo M, Bridges TM, Noetzel MJ, Cho HP, Lamsal A, Smith E, Chase P, Hodder PS, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Wood MR
High-resolution visualisation of the states and pathways sampled in molecular dynamics simulations.
1. Sci Rep - published September 3, 2014
2. Blöchliger N, Vitalis A, Caflisch A
Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3.
1. J. Neurosci. - published September 3, 2014
2. Shanks NF, Cais O, Maruo T, Savas JN, Zaika EI, Azumaya CM, Yates JR, Greger I, Nakagawa T
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface.
1. Nature - published September 3, 2014
2. Huang J, Kang BH, Pancera M, Lee JH, Tong T, Feng Y, Imamichi H, Georgiev IS, Chuang GY, Druz A, Doria-Rose NA, Laub L, Sliepen K, van Gils MJ, de la Peña AT, Derking R, Klasse PJ, Migueles SA, Bailer RT, Alam M, Pugach P, Haynes BF, Wyatt RT, Sanders RW, Binley JM, Ward AB, Mascola JR, Kwong PD, Connors M
Cys-scanning disulfide crosslinking and bayesian modeling probe the transmembrane signaling mechanism of the histidine kinase, PhoQ.
1. Structure - published September 2, 2014
2. Molnar KS, Bonomi M, Pellarin R, Clinthorne GD, Gonzalez G, Goldberg SD, Goulian M, Sali A, DeGrado WF
Fatty acid flippase activity of UCP2 is essential for its proton transport in mitochondria.
1. Cell Metab. - published September 2, 2014
2. Berardi MJ, Chou JJ
Crystal structure of a nematode-infecting virus.
1. Proc. Natl. Acad. Sci. U.S.A. - published September 2, 2014
2. Guo YR, Hryc CF, Jakana J, Jiang H, Wang D, Chiu W, Zhong W, Tao YJ
Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone.
1. Proc. Natl. Acad. Sci. U.S.A. - published September 2, 2014
2. Muthurajan UM, Hepler MR, Hieb AR, Clark NJ, Kramer M, Yao T, Luger K
Assembly and dynamics of the autophagy-initiating Atg1 complex.
1. Proc. Natl. Acad. Sci. U.S.A. - published September 2, 2014
2. Stjepanovic G, Davies CW, Stanley RE, Ragusa MJ, Kim do J, Hurley JH
Structural similarity of secretins from type II and type III secretion systems.
1. Structure - published September 2, 2014
2. Tosi T, Estrozi LF, Job V, Guilvout I, Pugsley AP, Schoehn G, Dessen A
Sensitive and selective plasmon ruler nanosensors for monitoring the apoptotic drug response in leukemia.
1. ACS Nano - published September 2, 2014
2. Tajon CA, Seo D, Asmussen J, Shah N, Jun YW, Craik CS
Aromatic inhibitors derived from ammonia-pretreated lignocellulose hinder bacterial ethanologenesis by activating regulatory circuits controlling inhibitor efflux and detoxification.
1. Front Microbiol - published September 2, 2014
2. Keating DH, Zhang Y, Ong IM, McIlwain S, Morales EH, Grass JA, Tremaine M, Bothfeld W, Higbee A, Ulbrich A, Balloon AJ, Westphall MS, Aldrich J, Lipton MS, Kim J, Moskvin OV, Bukhman YV, Coon JJ, Kiley PJ, Bates DM, Landick R
Editorial overview: Engineering and design: Raising the bar through innovation and integration.
1. Curr. Opin. Struct. Biol. - published September 2, 2014
2. Koide S, Kortemme T
Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.
1. Nat Rev Drug Discov - published September 2, 2014
2. Conn PJ, Lindsley CW, Meiler J, Niswender CM
Dramatic improvement of crystals of large RNAs by cation replacement and dehydration.
1. Structure - published September 2, 2014
2. Zhang J, Ferré-D'Amaré AR
A molecular simulation protocol to avoid sampling redundancy and discover new states.
1. Biochim. Biophys. Acta - published September 2, 2014
2. Bacci M, Vitalis A, Caflisch A
Structural insights into the tumor-promoting function of the MTDH-SND1 complex.
1. Cell Rep - published September 2, 2014
2. Guo F, Wan L, Zheng A, Stanevich V, Wei Y, Satyshur KA, Shen M, Lee W, Kang Y, Xing Y
Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.
1. Leukemia - published September 1, 2014
2. Reynolds C, Roderick JE, LaBelle JL, Bird G, Mathieu R, Bodaar K, Colon D, Pyati U, Stevenson KE, Qi J, Harris M, Silverman LB, Sallan SE, Bradner JE, Neuberg DS, Look AT, Walensky LD, Kelliher MA, Gutierrez A
Structural and functional studies of a trans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction.
1. Proteins - published September 1, 2014
2. Piasecki SK, Zheng J, Axelrod AJ, Detelich ME, Keatinge-Clay AT
STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.
1. J Virol - published September 1, 2014
2. Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE Jr, Boyd KL, Moore ML, Zhou W, Peebles RS Jr
Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16.
1. Antimicrob Agents Chemother - published September 1, 2014
2. Mensa B, Howell GL, Scott R, DeGrado WF
Characterization and immunogenicity of a novel mosaic M HIV-1 gp140 trimer.
1. J. Virol. - published September 1, 2014
2. Nkolola JP, Bricault CA, Cheung A, Shields J, Perry J, Kovacs JM, Giorgi E, van Winsen M, Apetri A, Brinkman-van der Linden EC, Chen B, Korber B, Seaman MS, Barouch DH
Molecular landscape of the interaction between the urease accessory proteins UreE and UreG.
1. Biochim Biophys Acta - published September 1, 2014
2. Merloni A, Dobrovolska O, Zambelli B, Agostini F, Bazzani M, Musiani F, Ciurli S
FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.
1. Mol Biol Cell - published September 1, 2014
2. Schwartz JC, Podell ER, Han SS, Berry JD, Eggan KC, Cech TR
Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptation.
1. EMBO J. - published September 1, 2014
2. Díaz-Martínez LA, Karamysheva ZN, Warrington R, Li B, Wei S, Xie XJ, Roth MG, Yu H
Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries.
1. ACS Chem Neurosci - published September 1, 2014
2. Bagriantsev SN, Chatelain FC, Clark KA, Alagem N, Reuveny E, Minor DL Jr
Lipopolysaccharide assembly in the bacterial outer membrane revealed by X-ray crystallography.
1. Sci China Life Sci - published September 1, 2014
2. Jiang Y
ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery.
1. J Cell Sci - published September 1, 2014
2. Schuck S, Gallagher CM, Walter P
Traffic control: adaptor proteins guide dynein-cargo takeoff.
1. EMBO J. - published September 1, 2014
2. Cianfrocco MA, Leschziner AE
Remote control of myosin and kinesin motors using light-activated gearshifting.
1. Nat Nanotechnol - published September 1, 2014
2. Nakamura M, Chen L, Howes SC, Schindler TD, Nogales E, Bryant Z
Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum.
1. Nat Methods - published September 1, 2014
2. Wagner JC, Platt RJ, Goldfless SJ, Zhang F, Niles JC
Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target.
1. Science - published September 1, 2014
2. Mulepati S, Héroux A, Bailey S
Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase.
1. Bioorg. Med. Chem. Lett. - published September 1, 2014
2. Kumar VP, Cisneros JA, Frey KM, Castellanos-Gonzalez A, Wang Y, Gangjee A, White AC, Jorgensen WL, Anderson KS
A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry.
1. Nat. Chem. Biol. - published September 1, 2014
2. Herschhorn A, Gu C, Espy N, Richard J, Finzi A, Sodroski JG
Readmissions After Cardiac Surgery: Experience of the National Institutes of Health/Canadian Institutes of Health Research Cardiothoracic Surgical Trials Network.
1. Ann. Thorac. Surg. - published September 1, 2014
2. Iribarne A, Chang H, Alexander JH, Gillinov AM, Moquete E, Puskas JD, Bagiella E, Acker MA, Mayer ML, Ferguson TB, Burks S, Perrault LP, Welsh S, Johnston KC, Murphy M, DeRose JJ, Neill A, Dobrev E, Baio KT, Taddei-Peters W, Moskowitz AJ, O'Gara PT
Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.
1. Nat. Struct. Mol. Biol. - published September 1, 2014
2. Hara K, Zheng G, Qu Q, Liu H, Ouyang Z, Chen Z, Tomchick DR, Yu H
Carboplatin binding to histidine.
1. Acta Crystallogr F Struct Biol Commun - published September 1, 2014
2. Tanley SW, Diederichs K, Kroon-Batenburg LM, Levy C, Schreurs AM, Helliwell JR
The structure of alanine racemase from Acinetobacter baumannii.
1. Acta Crystallogr F Struct Biol Commun - published September 1, 2014
2. Davis E, Scaletti-Hutchinson E, Opel-Reading H, Nakatani Y, Krause KL
Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.
1. Proc Natl Acad Sci U S A - published September 1, 2014
2. Foijer F, Xie SZ, Simon JE, Bakker PL, Conte N, Davis SH, Kregel E, Jonkers J, Bradley A, Sorger PK
EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice.
1. Sci Transl Med - published September 1, 2014
2. Flores-Mireles AL, Pinkner JS, Caparon MG, Hultgren SJ