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125 Member Publications for August 2014

Coupling of g proteins to reconstituted monomers and tetramers of the M2 muscarinic receptor.
1. J. Biol. Chem. - published August 29, 2014
2. Redka DS, Morizumi T, Elmslie G, Paranthaman P, Shivnaraine RV, Ellis J, Ernst OP, Wells JW
A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrimeric Gi protein α subunit.
1. J. Biol. Chem. - published August 29, 2014
2. Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE
RNA-guided assembly of Rev-RRE nuclear export complexes.
1. Elife - published August 29, 2014
2. Bai Y, Tambe A, Zhou K, Doudna JA
Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
1. Nat Commun - published August 29, 2014
2. Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, Toro A, Lucas JL, Vuga D, Lehmann L, Durocher D, Zeng Q, Patterson JB, Sicheri F
von Willebrand factor, Jedi knight of the bloodstream.
1. Blood - published August 28, 2014
2. Springer TA
Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.
1. Cell - published August 28, 2014
2. Kranzusch PJ, Lee AS, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA
Structure of RNA 3'-phosphate cyclase bound to substrate RNA.
1. RNA - published August 28, 2014
2. Desai KK, Bingman CA, Cheng CL, Phillips GN, Raines RT
Evolution of substrate specificity in bacterial AA10 lytic polysaccharide monooxygenases.
1. Biotechnol Biofuels - published August 28, 2014
2. Book AJ, Yennamalli RM, Takasuka TE, Currie CR, Phillips GN, Fox BG
ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue.
1. Mol Metab - published August 28, 2014
2. Kim M, Neinast MD, Frank AP, Sun K, Park J, Zehr JA, Vishvanath L, Morselli E, Amelotte M, Palmer BF, Gupta RK, Scherer PE, Clegg DJ
Comparative analysis of the transcriptome across distant species.
1. Nature - published August 28, 2014
2. Gerstein MB, Rozowsky J, Yan KK, Wang D, Cheng C, Brown JB, Davis CA, Hillier L, Sisu C, Li JJ, Pei B, Harmanci AO, Duff MO, Djebali S, Alexander RP, Alver BH, Auerbach R, Bell K, Bickel PJ, Boeck ME, Boley NP, Booth BW, Cherbas L, Cherbas P, Di C, Dobin A, Drenkow J, Ewing B, Fang G, Fastuca M, Feingold EA, Frankish A, Gao G, Good PJ, Guigó R, Hammonds A, Harrow J, Hoskins RA, Howald C, Hu L, Huang H, Hubbard TJ, Huynh C, Jha S, Kasper D, Kato M, Kaufman TC, Kitchen RR, Ladewig E, Lagarde J, Lai E, Leng J, Lu Z, MacCoss M, May G, McWhirter R, Merrihew G, Miller DM, Mortazavi A, Murad R, Oliver B, Olson S, Park PJ, Pazin MJ, Perrimon N, Pervouchine D, Reinke V, Reymond A, Robinson G, Samsonova A, Saunders GI, Schlesinger F, Sethi A, Slack FJ, Spencer WC, Stoiber MH, Strasbourger P, Tanzer A, Thompson OA, Wan KH, Wang G, Wang H, Watkins KL, Wen J, Wen K, Xue C, Yang L, Yip K, Zaleski C, Zhang Y, Zheng H, Brenner SE, Graveley BR, Celniker SE, Gingeras TR, Waterston R
Molecular architecture of the 40S⋅eIF1⋅eIF3 translation initiation complex.
1. Cell - published August 28, 2014
2. Erzberger JP, Stengel F, Pellarin R, Zhang S, Schaefer T, Aylett CH, Cimermančič P, Boehringer D, Sali A, Aebersold R, Ban N
Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence.
1. World J. Gastroenterol. - published August 28, 2014
2. Liu CJ, Chang J, Lee PH, Lin DY, Wu CC, Jeng LB, Lin YJ, Mok KT, Lee WC, Yeh HZ, Ho MC, Yang SS, Yang MD, Yu MC, Hu RH, Peng CY, Lai KL, Chang SS, Chen PJ
Single-cell identity generated by combinatorial homophilic interactions between α, β, and γ protocadherins.
1. Cell - published August 28, 2014
2. Thu CA, Chen WV, Rubinstein R, Chevee M, Wolcott HN, Felsovalyi KO, Tapia JC, Shapiro L, Honig B, Maniatis T
Favorable Outcomes in Elderly Patients Undergoing High-Dose Therapy and Autologous Stem Cell Transplantation for Non-Hodgkin Lymphoma.
1. Biol. Blood Marrow Transplant. - published August 28, 2014
2. Dahi PB, Tamari R, Devlin SM, Maloy M, Bhatt V, Scordo M, Goldberg J, Zelenetz AD, Hamlin PA, Matasar MJ, Maragulia J, Giralt SA, Perales MA, Moskowitz CH, Sauter CS
Small heterocycles in multicomponent reactions.
1. Chem. Rev. - published August 27, 2014
2. Rotstein BH, Zaretsky S, Rai V, Yudin AK
Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
1. J. Am. Chem. Soc. - published August 27, 2014
2. Ragland DA, Nalivaika EA, Nalam MN, Prachanronarong KL, Cao H, Bandaranayake RM, Cai Y, Kurt-Yilmaz N, Schiffer CA
Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics.
1. J. Am. Chem. Soc. - published August 27, 2014
2. Galligan JJ, Rose KL, Beavers WN, Hill S, Tallman KA, Tansey WP, Marnett LJ
Biochemical Characterization and Crystal Structures of a Fungal Family 3 β-Glucosidase, Cel3A from Hypocrea jecorina.
1. J. Biol. Chem. - published August 27, 2014
2. Karkehabadi S, Helmich KE, Kaper T, Hansson H, Mikkelsen NE, Gudmundsson M, Piens K, Fujdala M, Banerjee G, Scott-Craig JS, Walton JD, Phillips GN, Sandgren M
Small molecule Mcl-1 inhibitors for the treatment of cancer.
1. Pharmacol. Ther. - published August 27, 2014
2. Belmar J, Fesik SW
Total synthesis of viridicatumtoxin B and analogues thereof: strategy evolution, structural revision, and biological evaluation.
1. J. Am. Chem. Soc. - published August 27, 2014
2. Nicolaou KC, Hale CR, Nilewski C, Ioannidou HA, ElMarrouni A, Nilewski LG, Beabout K, Wang TT, Shamoo Y
Functional evolution of ribonuclease inhibitor: insights from birds and reptiles.
1. J. Mol. Biol. - published August 26, 2014
2. Lomax JE, Bianchetti CM, Chang A, Phillips GN, Fox BG, Raines RT
KIF14 binds tightly to microtubules and adopts a rigor-like conformation.
1. J. Mol. Biol. - published August 26, 2014
2. Arora K, Talje L, Asenjo AB, Andersen P, Atchia K, Joshi M, Sosa H, Allingham JS, Kwok BH
Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids.
1. Proc. Natl. Acad. Sci. U.S.A. - published August 26, 2014
2. Santa Maria JP, Sadaka A, Moussa SH, Brown S, Zhang YJ, Rubin EJ, Gilmore MS, Walker S
B cell homeostasis and follicle confines are governed by fibroblastic reticular cells.
1. Nat. Immunol. - published August 25, 2014
2. Cremasco V, Woodruff MC, Onder L, Cupovic J, Nieves-Bonilla JM, Schildberg FA, Chang J, Cremasco F, Harvey CJ, Wucherpfennig K, Ludewig B, Carroll MC, Turley SJ
How lamina-associated polypeptide 1 (LAP1) activates Torsin.
1. Elife - published August 24, 2014
2. Sosa BA, Demircioglu FE, Chen JZ, Ingram J, Ploegh HL, Schwartz TU
Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide.
1. J. Biol. Chem. - published August 22, 2014
2. Yin L, Trenh P, Guce A, Wieczorek M, Lange S, Sticht J, Jiang W, Bylsma M, Mellins ED, Freund C, Stern LJ
Assembly mechanism of Trypanosoma brucei BILBO1, a multidomain cytoskeletal protein.
1. J. Biol. Chem. - published August 22, 2014
2. Vidilaseris K, Shimanovskaya E, Esson HJ, Morriswood B, Dong G
Impact on Pulmonary Arterial Pressures after Repeated Endovascular Thrombectomy of Dialysis Grafts: A Prospective Follow-up Study.
1. J Vasc Interv Radiol - published August 22, 2014
2. Hsieh MY, Lai CL, Wu YW, Lin L, Ho MC, Wu CC
Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I.
1. Mol. Cell - published August 21, 2014
2. Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor KE, Walz T, Penczek PA, Hur S
Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.
1. Mol. Cell - published August 21, 2014
2. Shan C, Elf S, Ji Q, Kang HB, Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J
A novel zebrafish model to provide mechanistic insights into the inflammatory events in carrageenan-induced abdominal edema.
1. PLoS One - published August 21, 2014
2. Huang SY, Feng CW, Hung HC, Chakraborty C, Chen CH, Chen WF, Jean YH, Wang HM, Sung CS, Sun YM, Wu CY, Liu W, Hsiao CD, Wen ZH
Selection of chromosomal DNA libraries using a multiplex CRISPR system.
1. Elife - published August 21, 2014
2. Ryan OW, Skerker JM, Maurer MJ, Li X, Tsai JC, Poddar S, Lee ME, DeLoache W, Dueber JE, Arkin AP, Cate JH
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
1. Nature - published August 21, 2014
2. Althoff T, Hibbs RE, Banerjee S, Gouaux E
Nucleotide-dependent interactions within a specialized Hsp70/Hsp40 complex involved in Fe-S cluster biogenesis.
1. J. Am. Chem. Soc. - published August 20, 2014
2. Kim JH, Alderson TR, Frederick RO, Markley JL
The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue.
1. Neuron - published August 20, 2014
2. Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HD, Svergun DI, Zhang Y, Wang JH, Meijers R
Chemically modified peptide scaffolds target the CFTR-associated ligand PDZ domain.
1. PLoS One - published August 20, 2014
2. Amacher JF, Zhao R, Spaller MR, Madden DR
Threonine 149 phosphorylation enhances ΔFosB transcriptional activity to control psychomotor responses to cocaine.
1. J. Neurosci. - published August 20, 2014
2. Cates HM, Thibault M, Pfau M, Heller E, Eagle A, Gajewski P, Bagot R, Colangelo C, Abbott T, Rudenko G, Neve R, Nestler EJ, Robison AJ
Sensitive, selective analysis of selenium oxoanions using microchip electrophoresis with contact conductivity detection.
1. Anal. Chem. - published August 19, 2014
2. Noblitt SD, Staicu LC, Ackerson CJ, Henry CS
pH-induced conformational change of IscU at low pH correlates with protonation/deprotonation of two conserved histidine residues.
1. Biochemistry - published August 19, 2014
2. Dai Z, Kim JH, Tonelli M, Ali IK, Markley JL
Protective hinge in insulin opens to enable its receptor engagement.
1. Proc. Natl. Acad. Sci. U.S.A. - published August 19, 2014
2. Menting JG, Yang Y, Chan SJ, Phillips NB, Smith BJ, Whittaker J, Wickramasinghe NP, Whittaker LJ, Pandyarajan V, Wan ZL, Yadav SP, Carroll JM, Strokes N, Roberts CT, Ismail-Beigi F, Milewski W, Steiner DF, Chauhan VS, Ward CW, Weiss MA, Lawrence MC
Crystal structures of designed armadillo repeat proteins: Implications of construct design and crystallization conditions on overall structure.
1. Protein Sci. - published August 19, 2014
2. Reichen C, Madhurantakam C, Plückthun A, Mittl PR
Double homeobox gene, Duxbl, promotes myoblast proliferation and abolishes myoblast differentiation by blocking MyoD transactivation.
1. Cell Tissue Res. - published August 19, 2014
2. Wu SL, Li GZ, Chou CY, Tsai MS, Chen YP, Li CJ, Liou GG, Chang WW, Chen SL, Wang SH
The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.
1. Sci Signal - published August 19, 2014
2. Kiuchi T, Ortiz-Zapater E, Monypenny J, Matthews DR, Nguyen LK, Barbeau J, Coban O, Lawler K, Burford B, Rolfe DJ, de Rinaldis E, Dafou D, Simpson MA, Woodman N, Pinder S, Gillett CE, Devauges V, Poland SP, Fruhwirth G, Marra P, Boersma YL, Plückthun A, Gullick WJ, Yarden Y, Santis G, Winn M, Kholodenko BN, Martin-Fernandez ML, Parker P, Tutt A, Ameer-Beg SM, Ng T
Manipulation of receptor oligomerization as a strategy to inhibit signaling by TNF superfamily members.
1. Sci Signal - published August 19, 2014
2. Warren JT, Nelson CA, Decker CE, Zou W, Fremont DH, Teitelbaum SL
From perylene to a 22-ring aromatic hydrocarbon in one-pot.
1. Angew. Chem. Int. Ed. Engl. - published August 18, 2014
2. Schuler B, Collazos S, Gross L, Meyer G, Pérez D, Guitián E, Peña D
Sac1-Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus.
1. J. Cell Biol. - published August 18, 2014
2. Cai Y, Deng Y, Horenkamp F, Reinisch KM, Burd CG
The development and application of a quantitative peptide microarray based approach to protein interaction domain specificity space.
1. Mol. Cell Proteomics - published August 18, 2014
2. Engelmann BW, Kim Y, Wang M, Peters B, Rock RS, Nash PD
Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex.
1. Elife - published August 17, 2014
2. Nangle SN, Rosensweig C, Koike N, Tei H, Takahashi JS, Green CB, Zheng N
Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors.
1. Bioorg. Med. Chem. Lett. - published August 15, 2014
2. Barnes-Seeman D, Boiselle C, Capacci-Daniel C, Chopra R, Hoffmaster K, Jones CT, Kato M, Lin K, Ma S, Pan G, Shu L, Wang J, Whiteman L, Xu M, Zheng R, Fu J
7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds.
1. Bioorg. Med. Chem. Lett. - published August 15, 2014
2. D'Erasmo MP, Smith WB, Munoz A, Mohandas P, Au AS, Marineau JJ, Quadri LE, Bradner JE, Murelli RP
4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis.
1. Oncotarget - published August 15, 2014
2. Yi T, Kabha E, Papadopoulos E, Wagner G
Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms.
1. Elife - published August 15, 2014
2. Lai Y, Diao J, Cipriano DJ, Zhang Y, Pfuetzner RA, Padolina MS, Brunger AT
A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.
1. Genes Dev. - published August 15, 2014
2. Cheng Z, Cheung P, Kuo AJ, Yukl ET, Wilmot CM, Gozani O, Patel DJ
Hydrocarbon-stapled peptides: principles, practice, and progress.
1. J. Med. Chem. - published August 14, 2014
2. Walensky LD, Bird GH
α-Borylcarbonyl compounds: from transient intermediates to robust building blocks.
1. Dalton Trans - published August 14, 2014
2. He Z, Zajdlik A, Yudin AK
Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14α-demethylase: two regions of the enzyme molecule potentiate its inhibition.
1. J. Med. Chem. - published August 14, 2014
2. Friggeri L, Hargrove TY, Rachakonda G, Williams AD, Wawrzak Z, Di Santo R, De Vita D, Waterman MR, Tortorella S, Villalta F, Lepesheva GI
Visualization of arrestin recruitment by a G-protein-coupled receptor.
1. Nature - published August 14, 2014
2. Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, Chen X, Hanna R, Choi M, Yao XJ, Klink BU, Kahsai AW, Sidhu SS, Koide S, Penczek PA, Kossiakoff AA, Woods VL, Kobilka BK, Skiniotis G, Lefkowitz RJ
Pyrrolo[3,2-b]quinoxaline derivatives as types I1/2 and II Eph tyrosine kinase inhibitors: structure-based design, synthesis, and in vivo validation.
1. J. Med. Chem. - published August 14, 2014
2. Unzue A, Dong J, Lafleur K, Zhao H, Frugier E, Caflisch A, Nevado C
Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.
1. Cell - published August 14, 2014
2. Dürr KL, Chen L, Stein RA, De Zorzi R, Folea IM, Walz T, Mchaourab HS, Gouaux E
Defining the recognition elements of Lewis Y-reactive antibodies.
1. PLoS ONE - published August 14, 2014
2. Saha S, Pashov A, Siegel ER, Murali R, Kieber-Emmons T
DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.
1. Elife - published August 14, 2014
2. Costa A, Renault L, Swuec P, Petojevic T, Pesavento JJ, Ilves I, MacLellan-Gibson K, Fleck RA, Botchan MR, Berger JM
Selective methyl labeling of eukaryotic membrane proteins using cell-free expression.
1. J. Am. Chem. Soc. - published August 13, 2014
2. Linser R, Gelev V, Hagn F, Arthanari H, Hyberts SG, Wagner G
ω-Alkynyl lipid surrogates for polyunsaturated fatty acids: free radical and enzymatic oxidations.
1. J. Am. Chem. Soc. - published August 13, 2014
2. Beavers WN, Serwa R, Shimozu Y, Tallman KA, Vaught M, Dalvie ED, Marnett LJ, Porter NA
A type VI secretion-related pathway in Bacteroidetes mediates interbacterial antagonism.
1. Cell Host Microbe - published August 13, 2014
2. Russell AB, Wexler AG, Harding BN, Whitney JC, Bohn AJ, Goo YA, Tran BQ, Barry NA, Zheng H, Peterson SB, Chou S, Gonen T, Goodlett DR, Goodman AL, Mougous JD
Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.
1. Cell Host Microbe - published August 13, 2014
2. Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, Berry KN, Yen B, Hamilton J, Brett TJ, Pappu RV, Leung DW, Basler CF, Amarasinghe GK
Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity.
1. Proc. Natl. Acad. Sci. U.S.A. - published August 12, 2014
2. Xu L, Zhang L, Chong J, Xu J, Huang X, Wang D
mRNA transport meets membrane traffic.
1. Trends Genet. - published August 12, 2014
2. Jansen RP, Niessing D, Baumann S, Feldbrügge M
Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease.
1. J Chem Theory Comput - published August 12, 2014
2. Cai Y, Myint W, Paulsen JL, Schiffer CA, Ishima R, Kurt Yilmaz N
RNA polymerase pausing and nascent-RNA structure formation are linked through clamp-domain movement.
1. Nat. Struct. Mol. Biol. - published August 11, 2014
2. Hein PP, Kolb KE, Windgassen T, Bellecourt MJ, Darst SA, Mooney RA, Landick R
Uric acid and thiocyanate as competing substrates of lactoperoxidase.
1. J Biol Chem - published August 8, 2014
2. Seidel A, Parker H, Turner R, Dickerhof N, Khalilova IS, Wilbanks SM, Kettle AJ, Jameson GN
Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5.
1. Front Immunol - published August 8, 2014
2. Reikine S, Nguyen JB, Modis Y
The bromodomain of Gcn5 regulates site-specificity of lysine acetylation on histone H3.
1. Mol. Cell Proteomics - published August 8, 2014
2. Cieniewicz AM, Moreland L, Ringel AE, Mackintosh SG, Raman A, Gilbert TM, Wolberger C, Tackett AJ, Taverna SD
E pluribus unum, no more: from one crystal, many conformations.
1. Curr. Opin. Struct. Biol. - published August 8, 2014
2. Woldeyes RA, Sivak DA, Fraser JS
A motif in LILRB2 critical for Angptl2 binding and activation.
1. Blood - published August 7, 2014
2. Deng M, Lu Z, Zheng J, Wan X, Chen X, Hirayasu K, Sun H, Lam Y, Chen L, Wang Q, Song C, Huang N, Gao GF, Jiang Y, Arase H, Zhang CC
Radiofrequency heating pathways for gold nanoparticles.
1. Nanoscale - published August 7, 2014
2. Collins CB, McCoy RS, Ackerson BJ, Collins GJ, Ackerson CJ
Mechanism of DNA methylation-directed histone methylation by KRYPTONITE.
1. Mol. Cell - published August 7, 2014
2. Du J, Johnson LM, Groth M, Feng S, Hale CJ, Li S, Vashisht AA, Gallego-Bartolome J, Wohlschlegel JA, Patel DJ, Jacobsen SE
A dynamin mutant defines a superconstricted prefission state.
1. Cell Rep - published August 7, 2014
2. Sundborger AC, Fang S, Heymann JA, Ray P, Chappie JS, Hinshaw JE
A tethered delivery mechanism explains the catalytic action of a microtubule polymerase.
1. Elife - published August 7, 2014
2. Ayaz P, Munyoki S, Geyer EA, Piedra FA, Vu ES, Bromberg R, Otwinowski Z, Grishin NV, Brautigam CA, Rice LM
Reconstitution of peptidoglycan cross-linking leads to improved fluorescent probes of cell wall synthesis.
1. J. Am. Chem. Soc. - published August 6, 2014
2. Lebar MD, May JM, Meeske AJ, Leiman SA, Lupoli TJ, Tsukamoto H, Losick R, Rudner DZ, Walker S, Kahne D
Redefining the DNA-binding domain of human XPA.
1. J. Am. Chem. Soc. - published August 6, 2014
2. Sugitani N, Shell SM, Soss SE, Chazin WJ
An H3K36me3 binding PWWP protein targets the NuA3 acetyltransferase complex to coordinate transcriptional elongation at coding regions.
1. Mol. Cell Proteomics - published August 6, 2014
2. Gilbert TM, McDaniel SL, Byrum SD, Cades JA, Dancy BC, Wade H, Tackett AJ, Strahl BD, Taverna SD
Structure of the C. elegans ZYG-1 cryptic polo box suggests a conserved mechanism for centriolar docking of Plk4 kinases.
1. Structure - published August 5, 2014
2. Shimanovskaya E, Viscardi V, Lesigang J, Lettman MM, Qiao R, Svergun DI, Round A, Oegema K, Dong G
The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities.
1. Biochemistry - published August 5, 2014
2. Huoh YS, Ferguson KM
Structures of yeast 80S ribosome-tRNA complexes in the rotated and nonrotated conformations.
1. Structure - published August 5, 2014
2. Svidritskiy E, Brilot AF, Koh CS, Grigorieff N, Korostelev AA
Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.
1. Proc. Natl. Acad. Sci. U.S.A. - published August 5, 2014
2. Papadopoulos E, Jenni S, Kabha E, Takrouri KJ, Yi T, Salvi N, Luna RE, Gavathiotis E, Mahalingam P, Arthanari H, Rodriguez-Mias R, Yefidoff-Freedman R, Aktas BH, Chorev M, Halperin JA, Wagner G
Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes.
1. Proc. Natl. Acad. Sci. U.S.A. - published August 5, 2014
2. Goñi GM, Epifano C, Boskovic J, Camacho-Artacho M, Zhou J, Bronowska A, Martín MT, Eck MJ, Kremer L, Gräter F, Gervasio FL, Perez-Moreno M, Lietha D
Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE.
1. Nat Commun - published August 5, 2014
2. Wisedchaisri G, Park MS, Iadanza MG, Zheng H, Gonen T
The immunology connection--my first T cell receptor structure projects.
1. Protein Cell - published August 5, 2014
2. Wang JH
Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.
1. Sci Signal - published August 5, 2014
2. Wang X, Boyken SE, Hu J, Xu X, Rimer RP, Shea MA, Shaw AS, Andreotti AH, Huang YH
c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets.
1. Nat. Chem. Biol. - published August 4, 2014
2. Ren A, Patel DJ
High-resolution structure determination by continuous-rotation data collection in MicroED.
1. Nat. Methods - published August 4, 2014
2. Nannenga BL, Shi D, Leslie AG, Gonen T
A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand.
1. J. Biomol. NMR - published August 4, 2014
2. Sun Q, Phan J, Friberg AR, Camper DV, Olejniczak ET, Fesik SW
WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis.
1. Oncogene - published August 4, 2014
2. Vassilopoulos A, Tominaga Y, Kim HS, Lahusen T, Li B, Yu H, Gius D, Deng CX
Molecular dynamics in drug design.
1. Eur J Med Chem - published August 4, 2014
2. Zhao H, Caflisch A
Structural basis of lipid binding for the membrane-embedded tetraacyldisaccharide-1-phosphate 4'-kinase LpxK.
1. J Biol Chem - published August 2, 2014
2. Emptage RP, Tonthat NK, York JD, Schumacher MA, Zhou P
A conformational landscape for alginate secretion across the outer membrane of Pseudomonas aeruginosa.
1. Acta Crystallogr. D Biol. Crystallogr. - published August 2, 2014
2. Tan J, Rouse SL, Li D, Pye VE, Vogeley L, Brinth AR, El Arnaout T, Whitney JC, Howell PL, Sansom MS, Caffrey M
Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization.
1. Curr Protoc Immunol - published August 2, 2014
2. Yin L, Stern LJ
EFA6 controls Arf1 and Arf6 activation through a negative feedback loop.
1. Proc Natl Acad Sci U S A - published August 2, 2014
2. Padovani D, Folly-Klan M, Labarde A, Boulakirba S, Campanacci V, Franco M, Zeghouf M, Cherfils J
Intracellular neutralization of a virus using a cell-penetrating molecular transporter.
1. Nanomedicine (Lond) - published August 1, 2014
2. Sapparapu G, Sims AL, Aiyegbo MS, Shaikh FY, Harth EM, Crowe JE Jr
Two steps forward, one step back: determining XPD helicase mechanism by single-molecule fluorescence and high-resolution optical tweezers.
1. DNA Repair (Amst) - published August 1, 2014
2. Spies M
Atomic basis of CRM1-cargo recognition, release and inhibition.
1. Semin Cancer Biol - published August 1, 2014
2. Fung HY, Chook YM
Structure and function of the hydrophilic Photosystem II assembly proteins: Psb27, Psb28 and Ycf48.
1. Plant Physiol Biochem - published August 1, 2014
2. Mabbitt PD, Wilbanks SM, Eaton-Rye JJ
Single particle electron cryo-microscopy of a mammalian ion channel.
1. Curr Opin Struct Biol - published August 1, 2014
2. Liao M, Cao E, Julius D, Cheng Y
Protein structure determination by MicroED.
1. Curr Opin Struct Biol - published August 1, 2014
2. Nannenga BL, Gonen T
Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks.
1. Biochim Biophys Acta - published August 1, 2014
2. Du J, Patel DJ
Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap.
1. Mol Cell Proteomics - published August 1, 2014
2. Trentini DB, Fuhrmann J, Mechtler K, Clausen T
Structure and mechanism of COPI vesicle biogenesis.
1. Curr Opin Cell Biol - published August 1, 2014
2. Jackson LP
A chromogenic assay of substrate depletion by thiol dioxygenases.
1. Anal Biochem - published August 1, 2014
2. Fellner M, Doughty LM, Jameson GN, Wilbanks SM
The physiological target for LeuRS translational quality control is norvaline.
1. EMBO J - published August 1, 2014
2. Cvetesic N, Palencia A, Halasz I, Cusack S, Gruic-Sovulj I
Intricate protein-protein interactions in the cyanobacterial circadian clock.
1. J. Biol. Chem. - published August 1, 2014
2. Egli M
Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
1. ACS Chem Biol - published August 1, 2014
2. Li YC, Ho IH, Ku CC, Zhong YQ, Hu YP, Chen ZG, Chen CY, Lin WC, Zulueta MM, Hung SC, Lin MG, Wang CC, Hsiao CD
Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth.
1. J. Biol. Chem. - published August 1, 2014
2. Shan C, Kang HB, Elf S, Xie J, Gu TL, Aguiar M, Lonning S, Hitosugi T, Chung TW, Arellano M, Khoury HJ, Shin DM, Khuri FR, Boggon TJ, Fan J
Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency.
1. Bioorg. Med. Chem. Lett. - published August 1, 2014
2. Turlington M, Noetzel MJ, Bridges TM, Vinson PN, Steckler T, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Tong HM, Macdonald GJ, Daniels JS, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR
Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
1. Bioorg. Med. Chem. Lett. - published August 1, 2014
2. Bates BS, Rodriguez AL, Felts AS, Morrison RD, Venable DF, Blobaum AL, Byers FW, Lawson KP, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA
Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α.
1. Nat Neurosci - published August 1, 2014
2. Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Krnjević K, Kaufman RJ, Walter P, Costa-Mattioli M
A dimeric state for PRC2.
1. Nucleic Acids Res - published August 1, 2014
2. Davidovich C, Goodrich KJ, Gooding AR, Cech TR
Glucopyranosylidene-spiro-iminothiazolidinone, a new bicyclic ring system: synthesis, derivatization, and evaluation for inhibition of glycogen phosphorylase by enzyme kinetic and crystallographic methods.
1. Bioorg Med Chem - published August 1, 2014
2. Czifrák K, Páhi A, Deák S, Kiss-Szikszai A, Kövér KE, Docsa T, Gergely P, Alexacou KM, Papakonstantinou M, Leonidas DD, Zographos SE, Chrysina ED, Somsák L
The conserved potassium channel filter can have distinct ion binding profiles: structural analysis of rubidium, cesium, and barium binding in NaK2K.
1. J Gen Physiol - published August 1, 2014
2. Lam YL, Zeng W, Sauer DB, Jiang Y
Structural basis for activity of highly efficient RNA mimics of green fluorescent protein.
1. Nat Struct Mol Biol - published August 1, 2014
2. Warner KD, Chen MC, Song W, Strack RL, Thorn A, Jaffrey SR, Ferré-D'Amaré AR
Catalytic efficiency of designed catalytic proteins.
1. Curr Opin Struct Biol - published August 1, 2014
2. Korendovych IV, DeGrado WF
Improved vectors and genome-wide libraries for CRISPR screening.
1. Nat Methods - published August 1, 2014
2. Sanjana NE, Shalem O, Zhang F
General qPCR and Plate Reader Methods for Rapid Optimization of Membrane Protein Purification and Crystallization Using Thermostability Assays.
1. Curr Protoc Protein Sci - published August 1, 2014
2. Tomasiak TM, Pedersen BP, Chaudhary S, Rodriguez A, Colmanares YR, Roe-Zurz Z, Thamminana S, Tessema M, Stroud RM
Structural investigations of the RNA-binding properties of STAR proteins.
1. Biochem Soc Trans - published August 1, 2014
2. Feracci M, Foot J, Dominguez C
dxtbx: the diffraction experiment toolbox.
1. J Appl Crystallogr - published August 1, 2014
2. Parkhurst JM, Brewster AS, Fuentes-Montero L, Waterman DG, Hattne J, Ashton AW, Echols N, Evans G, Sauter NK, Winter G
Saffold cardiovirus and multiple sclerosis: no evidence for an association.
1. Ann Clin Transl Neurol - published August 1, 2014
2. Galama JM, Zoll JG, Lanke KH, de Jong AS, Melief J, Huitinga I, Verbeek MM, van Kuppeveld FJ