Member Publications

Jump to specific year:

78 Member Publications for March 2013

Energetic role of the paddle motif in voltage gating of Shaker K⁺ channels.
1. Nat Struct Mol Biol - published March 31, 2013
2. Z Lu, J Yamakaze, HG Shin, Y Ramu, Y Xu
Characterization of a dual-tropic Human immunodeficiency virus (HIV-1) strain derived from the prototypical X4 isolate HXBc2.
1. Virology - published March 30, 2013
2. J Sodroski, W Yuan, D Bowder, B Pacheco, SH Xiang
Design, Synthesis, and Structure-Activity Relationship Studies of Fluorescent Inhibitors of Cycloxygenase-2 as Targeted Optical Imaging Agents.
1. Bioconjug Chem - published March 28, 2013
2. LJ Marnett, K Ghebreselasie, BC Crews, MJ Uddin
A General, Enantioselective Synthesis of 1-Azabicyclo[m.n.0]alkane Ring Systems.
1. Tetrahedron Lett - published March 27, 2013
2. CW Lindsley, TE Wadzinski, LC Konkol, ML Schulte, TJ Senter
Forming Cross-Linked Peptidoglycan from Synthetic Gram-Negative Lipid II.
1. J Am Chem Soc - published March 27, 2013
2. D Kahne, S Walker, JM May, H Tsukamoto, TJ Lupoli, MD Lebar
Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains.
1. Proc Natl Acad Sci U S A - published March 27, 2013
2. PD Kwong, L Shapiro, JR Mascola, JC Mullikin, Program NISC Comparative Sequencing, WC Koff, DR Burton, M Simek, BF Haynes, SM Alam, J Blinn, KE Lloyd, J Eudailey, R Parks, Z Zhang, J Skinner, M Pancera, K McKee, G Lu, MK Louder, B Zhang, Y Yang, G Ofek, J Zhu
Structure and activity of the flagellar rotor protein FliY: A member of the CheC phosphatase family.
1. J Biol Chem - published March 26, 2013
2. BR Crane, G Gonzalez-Bonet, AM Bilwes, AR Greenswag, R Sircar
Role of Rhodobacter sphaeroides Photosynthetic Reaction Center Residue M214 in the Composition, Absorbance Properties, and Conformations of H_A and B_A Cofactors.
1. Biochemistry - published March 25, 2013
2. JT Beatty, ME Murphy, AG Mauk, FI Rosell, A Hardjasa, RG Saer
Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker.
1. Mol Cell Biol - published March 25, 2013
2. J Kuriyan, A Weiss, TA Kadlecek, S Deindl, PR Visperas, T Barros, Q Yan
Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain.
1. Proc Natl Acad Sci U S A - published March 25, 2013
2. S Subramaniam, ML Mayer, MJ Borgnia, A Bartesaghi, K Klymko, J Zhang, O Kuybeda, DM Schauder
A unified conformational selection and induced fit approach to protein-peptide docking.
1. PLoS One - published March 22, 2013
2. Trellet M, Melquiond AS, Bonvin AM
Updated structure of Drosophila cryptochrome.
1. Nature - published March 21, 2013
2. D Leys, BR Crane, NS Scrutton, MW Young, J Widom, D Top, AT Vaidya, AR Jones, BD Zoltowski, C Levy
DNA nanotubes for NMR structure determination of membrane proteins.
1. Nat Protoc - published March 21, 2013
2. WM Shih, JJ Chou, MA McClintock, G Bellot
Corrigendum: Structure of full-length Drosophila cryptochrome.
1. Nature - published March 20, 2013
2. AT Vaidya, BD Zoltowski, BR Crane, MW Young, J Widom, D Top
Polyprotein Context Regulates the Activity of Poliovirus 2CATPase Bound to Bilayer Nanodiscs.
1. J Virol - published March 20, 2013
2. OB Peersen, HP Huntoon, CL Springer
Structural Insights into the Regulation of Foreign Genes in Salmonella by the Hha/H-NS Complex.
1. J Biol Chem - published March 20, 2013
2. WW Navarre, PL Howell, H Robinson, J Stevenson, JC Whitney, SS Ali
Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation.
1. Proc Natl Acad Sci U S A - published March 19, 2013
2. JF Zhang, JM Pascal, M Zhang
NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
1. Proc Natl Acad Sci U S A - published March 19, 2013
2. M Ikura, BG Neel, MJ Smith
Need for and access to health care and medicines: are there gender inequities?
1. PLoS One - published March 19, 2013
2. Wagner AK, Graves AJ, Fan Z, Walker S, Zhang F, Ross-Degnan D
Impact of macromolecular crowding on DNA replication.
1. Nat Commun - published March 19, 2013
2. CC Richardson, G Wagner, SJ Lee, SR Akabayov, B Akabayov
A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy.
1. Proc Natl Acad Sci U S A - published March 18, 2013
2. JH Hurley, RE Stanley, MJ Ragusa, CC Jao
Molecular assembly of botulinum neurotoxin progenitor complexes.
1. Proc Natl Acad Sci U S A - published March 18, 2013
2. DB Lacy, MD Ohi, N Shine, SK Dessain, DA Benefield
SCF^FBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket.
1. Nature - published March 17, 2013
2. N Zheng, M Pagano, MF Bush, NH Saifee, ST Marionni, TR Hinds, L Busino, W Xing
The missing linker: a dimerization motif located within polyketide synthase modules.
1. ACS Chem Biol - published March 16, 2013
2. Zheng J, Fage CD, Demeler B, Hoffman DW, Keatinge-Clay AT
Using yeast to study potassium channel function and interactions with small molecules.
1. Methods Mol Biol - published March 16, 2013
2. Bagriantsev SN, Minor DL Jr
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.
1. Biol Psychiatry - published March 15, 2013
2. PJ Conn, CW Lindsley, CK Jones, JS Daniels, CM Niswender, Z Xiang, FE Dudek, SR Stauffer, KJ Gregory, JT Manka, RD Gogliotti, Y Zhou, HP Cho, PN Vinson, TM Bridges, WA Pouliot, MJ Noetzel, JM Rook
Cooperative Effects of Drug-Resistance Mutations in the Flap Region of HIV-1 Protease.
1. ACS Chem Biol - published March 15, 2013
2. CA Schiffer, RW Shafer, N Kurt Yilmaz, C Rosi, JE Foulkes-Murzycki
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule.
1. Bioorg Med Chem Lett - published March 15, 2013
2. JS Daniels, TJ Utley, TM Bridges, DJ Sheffler, PR Gentry, BJ Melancon, MS Poslusney, MR Wood, CW Lindsley, PJ Conn, CM Niswender
Secondary mechanisms of diversification in the human antibody repertoire.
1. Front Immunol - published March 14, 2013
2. Briney BS, Crowe JE Jr
Carboetomidate: An Analog of Etomidate That Interacts Weakly with 11β-Hydroxylase.
1. Anesth Analg - published March 14, 2013
2. DE Raines, KW Miller, R Ge, JF Cotten, R Bernhardt, J Neunzig, X Zhou, S Shanmugasundararaj
RNA-protein analysis using a conditional CRISPR nuclease.
1. Proc Natl Acad Sci U S A - published March 14, 2013
2. JA Doudna, L Bruhn, S Laderman, CD Wenger, B Smart, K Zhou, A Apffel, RE Haurwitz, HY Lee
Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer.
1. J Med Chem - published March 13, 2013
2. TM Penning, LJ Marnett, DW Christianson, Y Jin, MC Byrns, M Chen, AO Adeniji, AJ Liedtke
Development of Dual PLD1/2 and PLD2 Selective Inhibitors from a Common 1,3,8-Triazaspiro[4.5]decane Core: Discovery of ML298 and ML299 That Decrease Invasive Migration in U87-MG Glioblastoma Cells.
1. J Med Chem - published March 13, 2013
2. CW Lindsley, HA Brown, R Morrison, JS Daniels, PG Thomas, 3rd Oguin TH, KA Brown, SA Scott, MC O'Reilly
Viral counterattack against the host innate immune system.
1. Cell Res - published March 12, 2013
2. S Hur, B Wu
Rules for the recognition of dilysine retrieval motifs by coatomer.
1. EMBO J - published March 12, 2013
2. J Goldberg, W Ma
Architecture of the Soluble Receptor Aer2 Indicates an In-Line Mechanism for PAS and HAMP Domain Signaling.
1. J Mol Biol - published March 11, 2013
2. BR Crane, KJ Watts, JH Freed, PP Borbat, R Sircar, J Widom, N Sukomon, D Huh, MV Airola
7.5-Å Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase.
1. J Mol Biol - published March 11, 2013
2. M Leibundgut, N Ban, D Boehringer
Ring cycle for dilating and constricting the nuclear pore.
1. Proc Natl Acad Sci U S A - published March 11, 2013
2. I Melcák, G Blobel, SR Solmaz
Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.
1. Mol Cell - published March 7, 2013
2. Olsen SK, Lima CD
Structural model for the protein-translocating element of the twin-arginine transport system.
1. Proc Natl Acad Sci U S A - published March 7, 2013
2. JR Schnell, BC Berks, MS Sansom, CR Timmel, A De Riso, J Harmer, CE Tait, SL Rouse, F Rodriguez
Ordering a dynamic protein via a small-molecule stabilizer.
1. J Am Chem Soc - published March 6, 2013
2. Wang N, Majmudar CY, Pomerantz WC, Gagnon JK, Sadowsky JD, Meagher JL, Johnson TK, Stuckey JA, Brooks CL 3rd, Wells JA, Mapp AK
Antimalarial Activities of 6-Iodouridine and Its Prodrugs and Potential for Combination Therapy.
1. J Med Chem - published March 6, 2013
2. LP Kotra, KC Kain, EF Pai, P Malhotra, A Mohmmed, AM Bello, E Wasilewski, IE Crandall
Noddy, a Mouse Harboring a Missense Mutation in Protocadherin-15, Reveals the Impact of Disrupting a Critical Interaction Site between Tip-Link Cadherins in Inner Ear Hair Cells.
1. J Neurosci - published March 6, 2013
2. KN Alagramam, DP Corey, SD Brown, D Furness, R Gaudet, A Parker, G Ball, RE Hardisty-Hughes, DH Chen, J Gerka-Stuyt, SR Gopal, KJ Kinder, M Sotomayor, R Geng
Calmodulin mutations associated with recurrent cardiac arrest in infants.
1. Circulation - published March 5, 2013
2. Jr George AL, PJ Schwartz, WJ Chazin, TM Strom, T Meitinger, S Kääb, DW Benson, C Shaffer, T Clark, BM Beckmann, P Lichtner, T Wieland, M Pedrazzini, JD Kunic, SG Rathi, MD Feldkamp, J Papagiannis, M Ovadia, BF Cuneo, GM De Ferrari, E Graf, CN Johnson, L Crotti
The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics.
1. Structure - published March 5, 2013
2. Liu X, Shepherd TR, Murray AM, Xu Z, Fuentes EJ
The exomer cargo adaptor features a flexible hinge domain.
1. Structure - published March 5, 2013
2. Richardson BC, Fromme JC
Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters.
1. Proc Natl Acad Sci U S A - published March 5, 2013
2. Dreier B, Honegger A, Hess C, Nagy-Davidescu G, Mittl PR, Grütter MG, Belousova N, Mikheeva G, Krasnykh V, Plückthun A
Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens.
1. Proc Natl Acad Sci U S A - published March 5, 2013
2. Damo SM, Kehl-Fie TE, Sugitani N, Holt ME, Rathi S, Murphy WJ, Zhang Y, Betz C, Hench L, Fritz G, Skaar EP, Chazin WJ
Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase.
1. Proc Natl Acad Sci U S A - published March 5, 2013
2. Minnihan EC, Ando N, Brignole EJ, Olshansky L, Chittuluru J, Asturias FJ, Drennan CL, Nocera DG, Stubbe J
Responses of hair follicle-associated structures to loss of planar cell polarity signaling.
1. Proc Natl Acad Sci U S A - published March 5, 2013
2. Chang H, Nathans J
Amino acid-selective segmental isotope labeling of multidomain proteins for structural biology.
1. Chembiochem - published March 4, 2013
2. Michel E, Skrisovska L, Wüthrich K, Allain FH
VNI Cures Acute and Chronic Experimental Chagas Disease.
1. J Infect Dis - published March 4, 2013
2. GI Lepesheva, JN Johnston, MR Waterman, CA Johnson, TY Hargrove, YY Kleshchenko, PN Nde, MC Dobish, F Villalta
Tuning the Moenomycin Pharmacophore To Enable Discovery of Bacterial Cell Wall Synthesis Inhibitors.
1. J Am Chem Soc - published March 4, 2013
2. D Kahne, S Walker, EH Doud, H Tsukamoto, CM Gampe
Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex.
1. J Biomol NMR - published March 3, 2013
2. M Sattler, F Gabel, M Sonntag, I Wang, J Hennig
Structural visualization of key steps in human transcription initiation.
1. Nature - published March 2, 2013
2. He Y, Fang J, Taatjes DJ, Nogales E
Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity.
1. PLoS One - published March 2, 2013
2. Ho MC, Wilczek C, Bonanno JB, Xing L, Seznec J, Matsui T, Carter LG, Onikubo T, Kumar PR, Chan MK, Brenowitz M, Cheng RH, Reimer U, Almo SC, Shechter D
Structure and ubiquitination-dependent activation of TANK-binding kinase 1.
1. Cell Rep - published March 2, 2013
2. Tu D, Zhu Z, Zhou AY, Yun CH, Lee KE, Toms AV, Li Y, Dunn GP, Chan E, Thai T, Yang S, Ficarro SB, Marto JA, Jeon H, Hahn WC, Barbie DA, Eck MJ
Tertiary and quaternary allostery in tetrameric hemoglobin from Scapharca inaequivalvis.
1. Biochemistry - published March 2, 2013
2. Ronda L, Bettati S, Henry ER, Kashav T, Sanders JM, Royer WE, Mozzarelli A
Structure of EvaA: a paradigm for sugar 2,3-dehydratases.
1. Biochemistry - published March 2, 2013
2. Kubiak RL, Thoden JB, Holden HM
Xylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2.
1. Glycobiology - published March 1, 2013
2. Inamori K, Hara Y, Willer T, Anderson ME, Zhu Z, Yoshida-Moriguchi T, Campbell KP
Solvated protein-protein docking using Kyte-Doolittle-based water preferences.
1. Proteins - published March 1, 2013
2. Kastritis PL, Visscher KM, van Dijk AD, Bonvin AM
Advances in integrative modeling of biomolecular complexes.
1. Methods - published March 1, 2013
2. Karaca E, Bonvin AM
Non-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombe.
1. DNA Repair (Amst) - published March 1, 2013
2. Adhikary S, Cato MC, McGary KL, Rokas A, Eichman BF
A conserved asparagine has a structural role in ubiquitin-conjugating enzymes.
1. Nat Chem Biol - published March 1, 2013
2. Berndsen CE, Wiener R, Yu IW, Ringel AE, Wolberger C
Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog.
1. J Biol Chem - published March 1, 2013
2. Jayakar SS, Dailey WP, Eckenhoff RG, Cohen JB
Structural determinants of skeletal muscle ryanodine receptor gating.
1. J Biol Chem - published March 1, 2013
2. Ramachandran S, Chakraborty A, Xu L, Mei Y, Samsó M, Dokholyan NV, Meissner G
Conformational change and human cytochrome c function: mutation of residue 41 modulates caspase activation and destabilizes Met-80 coordination.
1. J Biol Inorg Chem - published March 1, 2013
2. Josephs TM, Liptak MD, Hughes G, Lo A, Smith RM, Wilbanks SM, Bren KL, Ledgerwood EC
Endoplasmic reticulum stress sensing in the unfolded protein response.
1. Cold Spring Harb Perspect Biol - published March 1, 2013
2. Gardner BM, Pincus D, Gotthardt K, Gallagher CM, Walter P
Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation.
1. Development - published March 1, 2013
2. Walcher T, Xie Q, Sun J, Irmler M, Beckers J, Öztürk T, Niessing D, Stoykova A, Cvekl A, Ninkovic J, Götz M
Structural determinants of specific lipid binding to potassium channels.
1. J Am Chem Soc - published March 1, 2013
2. Weingarth M, Prokofyev A, van der Cruijsen EA, Nand D, Bonvin AM, Pongs O, Baldus M
Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stability.
1. Cold Spring Harb Perspect Med - published March 1, 2013
2. Chong PA, Kota P, Dokholyan NV, Forman-Kay JD
A tissue-engineered human dermal construct utilizing fibroblasts and transforming growth factor β1 to promote elastogenesis.
1. Biotechnol J - published March 1, 2013
2. Sommer N, Sattler M, Weise JM, Wenck H, Gallinat S, Fischer F
The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors.
1. Genes Dev - published March 1, 2013
2. Dai Q, Ren A, Westholm JO, Serganov AA, Patel DJ, Lai EC
Structural basis of protein complex formation and reconfiguration by polyglutamine disease protein Ataxin-1 and Capicua.
1. Genes Dev - published March 1, 2013
2. Kim E, Lu HC, Zoghbi HY, Song JJ
Structure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulation.
1. Acta Crystallogr D Biol Crystallogr - published March 1, 2013
2. Correa A, Trajtenberg F, Obal G, Pritsch O, Dighiero G, Oppezzo P, Buschiazzo A
Mitochondrial NDUFS3 regulates the ROS-mediated onset of metabolic switch in transformed cells.
1. Biol Open - published March 1, 2013
2. Suhane S, Kanzaki H, Arumugaswami V, Murali R, Ramanujan VK
Theory and simulations of adhesion receptor dimerization on membrane surfaces.
1. Biophys J - published March 1, 2013
2. Wu Y, Honig B, Ben-Shaul A
How to draw the line in biomedical research.
1. Elife - published March 1, 2013
2. Huang L, Rattner A, Liu H, Nathans J