Member Publications

Jump to specific year:

82 Member Publications for February 2013

Probing the Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulator (PAM) Binding Pocket: Discovery of Point Mutations that Engender a "Molecular Switch" in PAM Pharmacology.
1. Mol Pharmacol - published February 26, 2013
2. PJ Conn, J Meiler, CW Lindsley, SR Stauffer, EF Squire, SD Reiff, ED Nguyen, KJ Gregory
N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function.
1. PLoS One - published February 23, 2013
2. Pancera M, Yang Y, Louder MK, Gorman J, Lu G, McLellan JS, Stuckey J, Zhu J, Burton DR, Koff WC, Mascola JR, Kwong PD
Paclitaxel-Conjugated PAMAM Dendrimers Adversely Affect Microtubule Structure through Two Independent Modes of Action.
1. Biomacromolecules - published February 21, 2013
2. NG Walter, RG Larson, JR Baker, G Skiniotis, E Meyhöfer, N Kaul, JF Herbstman, SK Choi, MH Li, EN Cline
Flexible backbone sampling methods to model and design protein alternative conformations.
1. Methods Enzymol - published February 21, 2013
2. Ollikainen N, Smith CA, Fraser JS, Kortemme T
HAMP domain conformers that propagate opposite signals in bacterial chemoreceptors.
1. PLoS Biol - published February 21, 2013
2. Airola MV, Sukomon N, Samanta D, Borbat PP, Freed JH, Watts KJ, Crane BR
Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition.
1. Cancer Discov - published February 21, 2013
2. K Stegmaier, JE Bradner, WA Weiss, AL Kung, CH Benes, U McDermott, MJ Garnett, P Greninger, WC Gustafson, R Zeid, EA Nekritz, YH Chanthery, J Qi, CF Bassil, G Alexe, SM Frumm, A Puissant
Membrane-Dependent Modulation of the mTOR Activator Rheb: NMR Observations of a GTPase Tethered to a Lipid-Bilayer Nanodisc.
1. J Am Chem Soc - published February 20, 2013
2. M Ikura, F Inagaki, LE Kay, V Stambolic, Y Kobashigawa, PB Stathopulos, CB Marshall, MT Mazhab-Jafari
The clathrin adaptor complexes as a paradigm for membrane-associated allostery.
1. Protein Sci - published February 19, 2013
2. JH Hurley, JS Bonifacino, X Ren, BJ Canagarajah
Ryanodine Receptor Calcium Release Channels: Lessons from structure-function studies.
1. FEBS J - published February 18, 2013
2. M Ikura, M Enomoto, PB Stathopulos, FJ Amador
Monomeric α-catenin links cadherin to the actin cytoskeleton.
1. Nat Cell Biol - published February 17, 2013
2. U Tepass, M Ikura, M Pellikka, N Ishiyama, R Sarpal, R Desai
Simultaneous Femtosecond X-ray Spectroscopy and Diffraction of Photosystem II at Room Temperature.
1. Science - published February 14, 2013
2. A Miahnahri, AR Fry, D Milathianaki, D Difiore, S Gul, G Han, A Lampe, S Koroidov, B Lassalle-Kaiser, RG Sierra, H Laksmono, J Hellmich, C Glöckner, N Echols, RJ Gildea, J Hattne, R Tran, R Alonso-Mori, J Kern, J Yano, U Bergmann, VK Yachandra, NK Sauter, A Zouni, J Messinger, S Boutet, GJ Williams, MJ Bogan, PD Adams, P Glatzel, WE White, PH Zwart, RW Grosse-Kunstleve, MJ Latimer, J Sellberg, TC Weng, D Sokaras, JE Koglin, MM Seibert, M Messerschmidt, DW Schafer
Superatom Paramagnetism Enables Gold Nanocluster Heating in Applied Radiofrequency Fields.
1. ACS Nano - published February 13, 2013
2. CJ Ackerson, BJ Ackerson, G Collins, S Choi, RS McCoy
Direct activation of full-length proapoptotic BAK.
1. Proc Natl Acad Sci U S A - published February 12, 2013
2. LD Walensky, GH Bird, CR Braun, ES Leshchiner
Mechanism of tetracycline resistance by ribosomal protection protein Tet(O).
1. Nat Commun - published February 12, 2013
2. J Frank, V Hauryliuk, KS Wilson, K Schulten, T Tenson, KY Chan, CC Lu, U Allas, NS Thakor, GC Atkinson, W Li
The Pyrrole Etomidate Analog Carboetomidate Potently Inhibits Human 5-HT3A Receptor Function: Comparisons with Etomidate and Potential Implications for Emetogenesis.
1. Anesth Analg - published February 11, 2013
2. DE Raines, KW Miller, R Desai
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome.
1. Nature - published February 10, 2013
2. J Frank, S Madison-Antenucci, E Westhof, C Bajaj, RA Grassucci, HY Liao, Q Zhang, A Jobe, F Jossinet, SN Buss, J Fu, A des Georges, Y Hashem
Direct molecular evolution of detergent-stable G protein-coupled receptors using polymer encapsulated cells.
1. J Mol Biol - published February 8, 2013
2. Scott DJ, Plückthun A
Structural Analysis of the Oligomeric States of Helicobacter pylori VacA Toxin.
1. J Mol Biol - published February 8, 2013
2. MD Ohi, TL Cover, DB Lacy, Y Takizawa, CK Yip, I Eli, SE Collier, C González-Rivera, TM Pyburn, MG Chambers
MERTK interactions with SH2-domain proteins in the retinal pigment epithelium.
1. PLoS One - published February 8, 2013
2. Shelby SJ, Colwill K, Dhe-Paganon S, Pawson T, Thompson DA
Loop-Loop Interactions Regulate KaiA-Stimulated KaiC Phosphorylation in the Cyanobacterial KaiABC Circadian Clock.
1. Biochemistry - published February 7, 2013
2. CH Johnson, JA Smith, T Mori, Y Xu, JH Sheehan, R Pattanayek, M Egli
Self-organization of the vesicular stomatitis virus nucleocapsid into a bullet shape.
1. Nat Commun - published February 7, 2013
2. Desfosses A, Ribeiro EA Jr, Schoehn G, Blondel D, Guilligay D, Jamin M, Ruigrok RW, Gutsche I
Revisiting the putative TCR Cα dimerization model through structural analysis.
1. Front Immunol - published February 7, 2013
2. Wang JH, Reinherz EL
Properties of cell death models calibrated and compared using Bayesian approaches.
1. Mol Syst Biol - published February 7, 2013
2. Eydgahi H, Chen WW, Muhlich JL, Vitkup D, Tsitsiklis JN, Sorger PK
Optimized phospholipid bilayer nanodiscs facilitate high-resolution structure determination of membrane proteins.
1. J Am Chem Soc - published February 6, 2013
2. G Wagner, T Raschle, M Etzkorn, F Hagn
Achieving Control over the Branched/Linear Selectivity in Palladium-Catalyzed Allylic Amination.
1. J Org Chem - published February 6, 2013
2. AK Yudin, ID Watson, I Dubovyk
A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors.
1. EMBO J - published February 6, 2013
2. Malvezzi F, Litos G, Schleiffer A, Heuck A, Mechtler K, Clausen T, Westermann S
Structural basis for conformational switching and GTP loading of the large G protein atlastin.
1. EMBO J - published February 6, 2013
2. H Sondermann, WR Zipfel, JP O'Donnell, NM Benvin, K Szeto, A Singh, LJ Byrnes
Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric complex.
1. PLoS One - published February 6, 2013
2. Stiegler AL, Grant TD, Luft JR, Calderwood DA, Snell EH, Boggon TJ
Nature of KaiB-KaiC binding in the cyanobacterial circadian oscillator.
1. Cell Cycle - published February 6, 2013
2. M Egli, MD Ohi, KK Yadagiri, R Pattanayek
A common structure for the potexviruses.
1. Virology - published February 5, 2013
2. J Groom, C Azzo, A Maris, W Bian, A Kendall, G Stubbs, JS Wall, PL Stewart, J Shi, D Williams
Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase.
1. Biochemistry - published February 5, 2013
2. Lokareddy RK, Bhardwaj A, Cingolani G
Cryo-electron microscopy three-dimensional structure of the jumbo phage ΦRSL1 infecting the phytopathogen Ralstonia solanacearum.
1. Structure - published February 5, 2013
2. Effantin G, Hamasaki R, Kawasaki T, Bacia M, Moriscot C, Weissenhorn W, Yamada T, Schoehn G
DNA repair: trust but verify.
1. Curr Biol - published February 4, 2013
2. Spies M
Full-length Gα(q)-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain.
1. Nat Struct Mol Biol - published February 3, 2013
2. JJ Tesmer, G Skiniotis, CA Boguth, S Dutta, AM Lyon
Substrate recognition of PLCγ1 via a specific docking surface on Itk.
1. J Mol Biol - published February 2, 2013
2. Xie Q, Joseph RE, Fulton DB, Andreotti AH
Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.
1. Mol Cell - published February 2, 2013
2. Liu W, Draheim KM, Zhang R, Calderwood DA, Boggon TJ
CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression.
1. Mol Cell - published February 2, 2013
2. Kim DY, Kwon E, Hartley PD, Crosby DC, Mann S, Krogan NJ, Gross JD
Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration.
1. Proc Natl Acad Sci U S A - published February 2, 2013
2. Bilguvar K, Tyagi NK, Ozkara C, Tuysuz B, Bakircioglu M, Choi M, Delil S, Caglayan AO, Baranoski JF, Erturk O, Yalcinkaya C, Karacorlu M, Dincer A, Johnson MH, Mane S, Chandra SS, Louvi A, Boggon TJ, Lifton RP, Horwich AL, Gunel M
The quiet renaissance of protein nuclear magnetic resonance.
1. Biochemistry - published February 2, 2013
2. Barrett PJ, Chen J, Cho MK, Kim JH, Lu Z, Mathew S, Peng D, Song Y, Van Horn WD, Zhuang T, Sönnichsen FD, Sanders CR
Structural and functional analysis of the DEAF-1 and BS69 MYND domains.
1. PLoS One - published February 2, 2013
2. Kateb F, Perrin H, Tripsianes K, Zou P, Spadaccini R, Bottomley M, Franzmann TM, Buchner J, Ansieau S, Sattler M
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.
1. Cell - published February 2, 2013
2. Yoo SH, Mohawk JA, Siepka SM, Shan Y, Huh SK, Hong HK, Kornblum I, Kumar V, Koike N, Xu M, Nussbaum J, Liu X, Chen Z, Chen ZJ, Green CB, Takahashi JS
Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.
1. Cell - published February 2, 2013
2. Hao YH, Doyle JM, Ramanathan S, Gomez TS, Jia D, Xu M, Chen ZJ, Billadeau DD, Rosen MK, Potts PR
Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.
1. Cell - published February 2, 2013
2. Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T
Numerical 3D modeling of heat transfer in human tissues for microwave radiometry monitoring of brown fat metabolism.
1. Proc SPIE Int Soc Opt Eng - published February 2, 2013
2. Rodrigues DB, Maccarini PF, Salahi S, Colebeck E, Topsakal E, Pereira PJ, Limão-Vieira P, Stauffer PR
ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding.
1. Cell Microbiol - published February 1, 2013
2. Effantin G, Dordor A, Sandrin V, Martinelli N, Sundquist WI, Schoehn G, Weissenhorn W
Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry.
1. Curr Opin Virol - published February 1, 2013
2. Stampfer SD, Heldwein EE
Synthase-dependent exopolysaccharide secretion in Gram-negative bacteria.
1. Trends Microbiol - published February 1, 2013
2. Whitney JC, Howell PL
Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry.
1. Anal Biochem - published February 1, 2013
2. Jiang H, Sherwood R, Zhang S, Zhu X, Liu Q, Graeff R, Kriksunov IA, Lee HC, Hao Q, Lin H
High-throughput identification of putative receptors for cancer-binding peptides using biopanning and microarray analysis.
1. Integr Biol (Camb) - published February 1, 2013
2. Ferraro DJ, Bhave SR, Kotipatruni RP, Hunn JC, Wildman SA, Hong C, Dadey DY, Muhoro LK, Jaboin JJ, Thotala D, Hallahan DE
Crystal structures of acetate kinases from the eukaryotic pathogens Entamoeba histolytica and Cryptococcus neoformans.
1. J Struct Biol - published February 1, 2013
2. Thaker TM, Tanabe M, Fowler ML, Preininger AM, Ingram-Smith C, Smith KS, Iverson TM
In-house UV radiation-damage-induced phasing of selenomethionine-labeled protein structures.
1. J Struct Biol - published February 1, 2013
2. Pereira PJ, Royant A, Panjikar S, de Sanctis D
The bacterial cytoskeleton: more than twisted filaments.
1. Curr Opin Cell Biol - published February 1, 2013
2. Pilhofer M, Jensen GJ
Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage.
1. Mol Cell Biol - published February 1, 2013
2. Mazumder A, Tummler K, Bathe M, Samson LD
Rho GTPases and their roles in cancer metabolism.
1. Trends Mol Med - published February 1, 2013
2. Wilson KF, Erickson JW, Antonyak MA, Cerione RA
Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome.
1. J Struct Biol - published February 1, 2013
2. Sharma G, Pallesen J, Das S, Grassucci R, Langlois R, Hampton CM, Kelly DF, des Georges A, Frank J
Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop.
1. J Biol Chem - published February 1, 2013
2. Amacher JF, Cushing PR, Bahl CD, Beck T, Madden DR
Production of a de-novo designed antimicrobial peptide in Nicotiana benthamiana.
1. Plant Mol Biol - published February 1, 2013
2. Zeitler B, Bernhard A, Meyer H, Sattler M, Koop HU, Lindermayr C
HIV-1 frameshift efficiency is primarily determined by the stability of base pairs positioned at the mRNA entrance channel of the ribosome.
1. Nucleic Acids Res - published February 1, 2013
2. Mouzakis KD, Lang AL, Vander Meulen KA, Easterday PD, Butcher SE
Modulation of quaternary structure and enhancement of ligand binding by the K-turn of tandem glycine riboswitches.
1. RNA - published February 1, 2013
2. Baird NJ, Ferré-D'Amaré AR
Engineering visual arrestin-1 with special functional characteristics.
1. J Biol Chem - published February 1, 2013
2. Vishnivetskiy SA, Chen Q, Palazzo MC, Brooks EK, Altenbach C, Iverson TM, Hubbell WL, Gurevich VV
RRM-RNA recognition: NMR or crystallography…and new findings.
1. Curr Opin Struct Biol - published February 1, 2013
2. Daubner GM, Cléry A, Allain FH
Cell-free production of integral membrane aspartic acid proteases reveals zinc-dependent methyltransferase activity of the Pseudomonas aeruginosa prepilin peptidase PilD.
1. Microbiologyopen - published February 1, 2013
2. Aly KA, Beebe ET, Chan CH, Goren MA, Sepúlveda C, Makino S, Fox BG, Forest KT
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.
1. Cell Cycle - published February 1, 2013
2. Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M
There and back again: new single-molecule insights in the motion of DNA repair proteins.
1. Curr Opin Struct Biol - published February 1, 2013
2. Spies M
FASTDEF: fast defocus and astigmatism estimation for high-throughput transmission electron microscopy.
1. J Struct Biol - published February 1, 2013
2. Vargas J, Otón J, Marabini R, Jonic S, de la Rosa-Trevín JM, Carazo JM, Sorzano CO
Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.
1. Nucleic Acids Res - published February 1, 2013
2. Patra A, Harp J, Pallan PS, Zhao L, Abramov M, Herdewijn P, Egli M
The high kinetic stability of a G-quadruplex limits hnRNP F qRRM3 binding to G-tract RNA.
1. Nucleic Acids Res - published February 1, 2013
2. Samatanga B, Dominguez C, Jelesarov I, Allain FH
Multiplex genome engineering using CRISPR/Cas systems.
1. Science - published February 1, 2013
2. Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Zhang F
A dual role for mycobacterial RecO in RecA-dependent homologous recombination and RecA-independent single-strand annealing.
1. Nucleic Acids Res - published February 1, 2013
2. Gupta R, Ryzhikov M, Koroleva O, Unciuleac M, Shuman S, Korolev S, Glickman MS
Finding the end: recruitment of telomerase to telomeres.
1. Nat Rev Mol Cell Biol - published February 1, 2013
2. Nandakumar J, Cech TR
Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency.
1. Bioorg Med Chem Lett - published February 1, 2013
2. Bollini M, Gallardo-Macias R, Spasov KA, Tirado-Rives J, Anderson KS, Jorgensen WL
A new structural framework for integrating replication protein A into DNA processing machinery.
1. Nucleic Acids Res - published February 1, 2013
2. Brosey CA, Yan C, Tsutakawa SE, Heller WT, Rambo RP, Tainer JA, Ivanov I, Chazin WJ
Single-molecule spectroscopy of protein folding dynamics--expanding scope and timescales.
1. Curr Opin Struct Biol - published February 1, 2013
2. Schuler B, Hofmann H
Conformational heterogeneity of the aspartate transporter Glt(Ph).
1. Nat Struct Mol Biol - published February 1, 2013
2. Hänelt I, Wunnicke D, Bordignon E, Steinhoff HJ, Slotboom DJ
Coordinating the impact of structural genomics on the human α-helical transmembrane proteome.
1. Nat Struct Mol Biol - published February 1, 2013
2. Pieper U, Schlessinger A, Kloppmann E, Chang GA, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, Stroud RM, Stevens RC, Sali A
HIV-1: packaging a shifty genome?
1. Cell Host Microbe - published February 1, 2013
2. Durney MA, D'Souza VM
Direct detection pays off for electron cryo-microscopy.
1. Elife - published February 1, 2013
2. Grigorieff N
MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication.
1. PLoS Pathog - published February 1, 2013
2. Fleming P, Kvansakul M, Voigt V, Kile BT, Kluck RM, Huang DC, Degli-Esposti MA, Andoniou CE
The apoptogenic toxin AIP56 is a metalloprotease A-B toxin that cleaves NF-κb P65.
1. PLoS Pathog - published February 1, 2013
2. Silva DS, Pereira LM, Moreira AR, Ferreira-da-Silva F, Brito RM, Faria TQ, Zornetta I, Montecucco C, Oliveira P, Azevedo JE, Pereira PJ, Macedo-Ribeiro S, do Vale A, dos Santos NM
Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates.
1. Elife - published February 1, 2013
2. Ivanovic T, Choi JL, Whelan SP, van Oijen AM, Harrison SC
Structure-based peptide mimicry of tumor-associated antigens.
1. Monoclon Antib Immunodiagn Immunother - published February 1, 2013
2. Ohtaki A, Kieber-Emmons T, Murali R
Noise analysis and performance comparison of low current measurement systems for biomedical applications.
1. IEEE Trans Biomed Circuits Syst - published February 1, 2013
2. Dongsoo Kim, Goldstein B, Wei Tang, Sigworth FJ, Culurciello E