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155 Member Publications for August 2022

Antibody-mediated immunity to SARS-CoV-2 spike.
1. Adv Immunol - published August 29, 2022
2. Errico JM, Adams LJ, Fremont DH
A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria.
1. Front Immunol - published August 22, 2022
2. Kreft L, Schepers A, Hils M, Swiontek K, Flatley A, Janowski R, Mirzaei MK, Dittmar M, Chakrapani N, Desai MS, Eyerich S, Deng L, Niessing D, Fischer K, Feederle R, Blank S, Schmidt-Weber CB, Hilger C, Biedermann T, Ohnmacht C
Humoral responses to the SARS-CoV-2 spike and receptor binding domain in context of pre-existing immunity confer broad sarbecovirus neutralization.
1. Front Immunol - published August 22, 2022
2. Hauser BM, Sangesland M, Lam EC, Feldman J, Balazs AB, Lingwood D, Schmidt AG
Monitoring functional RNA binding of RNA-dependent ATPase enzymes such as SF2 helicases using RNA dependent ATPase assays: A RIG-I case study.
1. Methods Enzymol - published August 14, 2022
2. Guo R, Pyle AM
Molecular dynamics analysis of the structural properties of the transglutaminases of Kutzneria albida and Streptomyces mobaraensis.
1. Comput Struct Biotechnol J - published August 11, 2022
2. Giordano D, Langini C, Caflisch A, Marabotti A, Facchiano A
Modular Adapters Utilizing Binders of Different Molecular Types Expand Cell-Targeting Options for Adenovirus Gene Delivery.
1. Bioconjug Chem - published August 9, 2022
2. Freitag PC, Brandl F, Brücher D, Weiss F, Dreier B, Plückthun A
The mechanism of RNA capping by SARS-CoV-2.
1. Nature - published August 9, 2022
2. Park GJ, Osinski A, Hernandez G, Eitson JL, Majumdar A, Tonelli M, Henzler-Wildman K, Pawłowski K, Chen Z, Li Y, Schoggins JW, Tagliabracci VS
A pathogenic proteolysis-resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function.
1. JCI Insight - published August 9, 2022
2. Kim H, Lenoir S, Helfricht A, Jung T, Karneva ZK, Lee Y, Beumer W, van der Horst GB, Anthonijsz H, Buil LC, van der Ham F, Platenburg GJ, Purhonen P, Hebert H, Humbert S, Saudou F, Klein P, Song JJ
SARS-CoV-2 hybrid immunity: silver bullet or silver lining?
1. Nat Rev Immunol - published August 9, 2022
2. Suryawanshi R, Ott M
Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
1. Elife - published August 8, 2022
2. Schrecker M, Castaneda JC, Devbhandari S, Kumar C, Remus D, Hite RK
Novel interaction interfaces mediate the interaction between the NEIL1 DNA glycosylase and mitochondrial transcription factor A.
1. Front Cell Dev Biol - published August 8, 2022
2. Sharma N, Thompson MK, Arrington JF, Terry DM, Chakravarthy S, Prevelige PE, Prakash A
Autoantibody mimicry of hormone action at the thyrotropin receptor.
1. Nature - published August 8, 2022
2. Faust B, Billesbølle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A
Programmable DARPin-based receptors for the detection of thrombotic markers.
1. Nat Chem Biol - published August 8, 2022
2. Strittmatter T, Wang Y, Bertschi A, Scheller L, Freitag PC, Ray PG, Stuecheli P, Schaefer JV, Reinberg T, Tsakiris D, Plückthun A, Ye H, Fussenegger M
Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
1. J Biol Chem - published August 8, 2022
2. Orlando BJ, Dominik PK, Roy S, Ogbu CP, Erramilli SK, Kossiakoff AA, Vecchio AJ
Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape.
1. Lancet Infect Dis - published August 8, 2022
2. Mazur NI, Terstappen J, Baral R, Bardají A, Beutels P, Buchholz UJ, Cohen C, Crowe JE Jr, Cutland CL, Eckert L, Feikin D, Fitzpatrick T, Fong Y, Graham BS, Heikkinen T, Higgins D, Hirve S, Klugman KP, Kragten-Tabatabaie L, Lemey P, Libster R, Löwensteyn Y, Mejias A, Munoz FM, Munywoki PK, Mwananyanda L, Nair H, Nunes MC, Ramilo O, Richmond P, Ruckwardt TJ, Sande C, Srikantiah P, Thacker N, Waldstein KA, Weinberger D, Wildenbeest J, Wiseman D, Zar HJ, Zambon M, Bont L
mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant.
1. Commun Biol - published August 6, 2022
2. Nanishi E, McGrath ME, O'Meara TR, Barman S, Yu J, Wan H, Dillen CA, Menon M, Seo HS, Song K, Xu AZ, Sebastian L, Brook B, Bosco AN, Borriello F, Ernst RK, Barouch DH, Dhe-Paganon S, Levy O, Frieman MB, Dowling DJ
Structural and dynamic mechanisms of GABA(A) receptor modulators with opposing activities.
1. Nat Commun - published August 6, 2022
2. Zhu S, Sridhar A, Teng J, Howard RJ, Lindahl E, Hibbs RE
BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
1. Cancer Discov - published August 5, 2022
2. Xia M, David L, Teater M, Gutierrez J, Wang X, Meydan C, Lytle A, Slack GW, Scott DW, Morin RD, Onder O, Elenitoba-Johnson KSJ, Zamponi N, Cerchietti L, Lu T, Philippar U, Fontan L, Wu H, Melnick AM
Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1.
1. Sci Adv - published August 5, 2022
2. Jones AN, Graß C, Meininger I, Geerlof A, Klostermann M, Zarnack K, Krappmann D, Sattler M
Immediate and Sustained Effects of Cobalt and Zinc-Containing Pigments on Macrophages.
1. Front Immunol - published August 5, 2022
2. Devcic J, Dussol M, Collin-Faure V, Pérard J, Fenel D, Schoehn G, Carrière M, Rabilloud T, Dalzon B
The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing.
1. PLoS Pathog - published August 5, 2022
2. Pfoh R, Subramanian AS, Huang J, Little DJ, Forman A, DiFrancesco BR, Balouchestani-Asli N, Kitova EN, Klassen JS, Pomès R, Nitz M, Howell PL
Structure-based evolutionary relationship between IscB and Cas9.
1. Cell Res - published August 5, 2022
2. Jia N, Patel DJ
Reply to Comment on "Binding Affinity Determines Substrate Specificity and Enables Discovery of substrates for N-Myristoyltransferases".
1. ACS Catal - published August 5, 2022
2. Su D, Kosciuk T, Lin H
Inhibition of H1 and H5 Influenza A Virus Entry by Diverse Macrocyclic Peptides Targeting the Hemagglutinin Stem Region.
1. ACS Chem Biol - published August 4, 2022
2. Pascha MN, Thijssen V, Egido JE, Linthorst MW, van Lanen JH, van Dongen DAA, Hopstaken AJP, van Kuppeveld FJM, Snijder J, de Haan CAM, Jongkees SAK
Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition.
1. Elife - published August 4, 2022
2. Li Y, Balakrishnan VK, Rowse M, Wu CG, Bravos AP, Yadav VK, Ivarsson Y, Strack S, Novikova IV, Xing Y
Rotavirus VP4 Epitope of a Broadly Neutralizing Human Antibody Defined by Its Structure Bound with an Attenuated-Strain Virion.
1. J Virol - published August 4, 2022
2. Jenni S, Li Z, Wang Y, Bessey T, Salgado EN, Schmidt AG, Greenberg HB, Jiang B, Harrison SC
PEX5 translocation into and out of peroxisomes drives matrix protein import.
1. Mol Cell - published August 4, 2022
2. Skowyra ML, Rapoport TA
A Review of Clinical Efficacy Data Supporting Emergency Use Authorization for COVID-19 Therapeutics and Lessons for Future Pandemics.
1. Clin Transl Sci - published August 4, 2022
2. Yoo SH, Kim L, Lu M, Nagoshi K, Namchuk MN
The SOS response-associated peptidase (SRAP) domain of YedK catalyzes ring opening of abasic sites and reversal of its DNA-protein crosslink.
1. J Biol Chem - published August 4, 2022
2. Paulin KA, Cortez D, Eichman BF
Short Arrestin-3-Derived Peptides Activate JNK3 in Cells.
1. Int J Mol Sci - published August 4, 2022
2. Perry-Hauser NA, Kaoud TS, Stoy H, Zhan X, Chen Q, Dalby KN, Iverson TM, Gurevich VV, Gurevich EV
A multispecific antibody confers pan-reactive SARS-CoV-2 neutralization and prevents immune escape.
1. bioRxiv - published August 4, 2022
2. Misasi J, Wei RR, Wang L, Pegu A, Wei CJ, Oloniniyi OK, Zhou T, Zhao B, Choe M, Boruszczak M, Chen M, Leung K, Li J, Yang ES, Yang ZY, Zhang Y, Carlton K, Harris DR, Ivleva VB, Lei P, Liu C, Longobardi L, Olia AS, Shi W, Wolff JJ, Gall J, Koup RA, Kwong PD, Mascola JR, Nabel GJ, Sullivan NJ
Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses.
1. Immunity - published August 4, 2022
2. Tas JMJ, Koo JH, Lin YC, Xie Z, Steichen JM, Jackson AM, Hauser BM, Wang X, Cottrell CA, Torres JL, Warner JE, Kirsch KH, Weldon SR, Groschel B, Nogal B, Ozorowski G, Bangaru S, Phelps N, Adachi Y, Eskandarzadeh S, Kubitz M, Burton DR, Lingwood D, Schmidt AG, Nair U, Ward AB, Schief WR, Batista FD
Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis.
1. mBio - published August 3, 2022
2. DiVenere AM, Amengor D, Silva RP, Goldsmith JA, McLellan JS, Maynard JA
¹⁵N-Detected TROSY NMR experiments to study large disordered proteins in high-field magnets.
1. Chem Commun (Camb) - published August 3, 2022
2. Dubey A, Viennet T, Chhabra S, Takeuchi K, Seo HC, Bermel W, Frueh DP, Arthanari H
Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-β-C-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects.
1. J Am Chem Soc - published August 3, 2022
2. Guenther DC, Mori S, Matsuda S, Gilbert JA, Willoughby JLS, Hyde S, Bisbe A, Jiang Y, Agarwal S, Madaoui M, Janas MM, Charisse K, Maier MA, Egli M, Manoharan M
A mitotic chromatin phase transition prevents perforation by microtubules.
1. Nature - published August 3, 2022
2. Schneider MWG, Gibson BA, Otsuka S, Spicer MFD, Petrovic M, Blaukopf C, Langer CCH, Batty P, Nagaraju T, Doolittle LK, Rosen MK, Gerlich DW
Teixobactin kills bacteria by a two-pronged attack on the cell envelope.
1. Nature - published August 3, 2022
2. Shukla R, Lavore F, Maity S, Derks MGN, Jones CR, Vermeulen BJA, Melcrová A, Morris MA, Becker LM, Wang X, Kumar R, Medeiros-Silva J, van Beekveld RAM, Bonvin AMJJ, Lorent JH, Lelli M, Nowick JS, MacGillavry HD, Peoples AJ, Spoering AL, Ling LL, Hughes DE, Roos WH, Breukink E, Lewis K, Weingarth M
The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis.
1. Immunity - published August 3, 2022
2. Leng F, Zhang W, Ramirez RN, Leon J, Zhong Y, Hou L, Yuki K, van der Veeken J, Rudensky AY, Benoist C, Hur S
Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential.
1. Stem Cell Reports - published August 3, 2022
2. Stutzman MJ, Kim CSJ, Tester DJ, Hamrick SK, Dotzler SM, Giudicessi JR, Miotto MC, Gc JB, Frank J, Marks AR, Ackerman MJ
A conserved sequence motif in the E. coli soluble FAD-containing pyridine nucleotide transhydrogenase is important for reaction efficiency.
1. J Biol Chem - published August 3, 2022
2. Partipilo M, Yang G, Mascotti ML, Wijma HJ, Slotboom DJ, Fraaije MW
Potently neutralizing and protective anti-human metapneumovirus antibodies target diverse sites on the fusion glycoprotein.
1. Immunity - published August 3, 2022
2. Rappazzo CG, Hsieh CL, Rush SA, Esterman ES, Delgado T, Geoghegan JC, Wec AZ, Sakharkar M, Más V, McLellan JS, Walker LM
Identification of mEAK-7 as a human V-ATPase regulator via cryo-EM data mining.
1. Proc Natl Acad Sci U S A - published August 3, 2022
2. Wang L, Wu D, Robinson CV, Fu TM
Conformation of von Willebrand factor in shear flow revealed with stroboscopic single-molecule imaging.
1. Blood - published August 3, 2022
2. Bergal HT, Jiang Y, Yang D, Springer TA, Wong WP
Chemically targeting the redox switch in AP1 transcription factor ΔFOSB.
1. Nucleic Acids Res - published August 3, 2022
2. Kumar A, Aglyamova G, Yim YY, Bailey AO, Lynch HM, Powell RT, Nguyen ND, Rosenthal Z, Zhao WN, Li Y, Chen J, Fan S, Lee H, Russell WK, Stephan C, Robison AJ, Haggarty SJ, Nestler EJ, Zhou J, Machius M, Rudenko G
Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations.
1. Elife - published August 3, 2022
2. Choudhary GS, Pellagatti A, Agianian B, Smith MA, Bhagat TD, Gordon-Mitchell S, Sahu S, Pandey S, Shah N, Aluri S, Aggarwal R, Aminov S, Schwartz L, Steeples V, Booher RN, Ramachandra M, Samson M, Carbajal M, Pradhan K, Bowman TV, Pillai MM, Will B, Wickrema A, Shastri A, Bradley RK, Martell RE, Steidl UG, Gavathiotis E, Boultwood J, Starczynowski DT, Verma A
Structural basis for activation of Arf1 at the Golgi complex.
1. Cell Rep - published August 3, 2022
2. Muccini AJ, Gustafson MA, Fromme JC
Structural basis of ion uptake in copper-transporting P_1B-type ATPases.
1. Nat Commun - published August 3, 2022
2. Salustros N, Grønberg C, Abeyrathna NS, Lyu P, Orädd F, Wang K, Andersson M, Meloni G, Gourdon P
Structures of a phycobilisome in light-harvesting and photoprotected states.
1. Nature - published August 3, 2022
2. Domínguez-Martín MA, Sauer PV, Kirst H, Sutter M, Bína D, Greber BJ, Nogales E, Polívka T, Kerfeld CA
Characterisation of a Seneca Valley virus thermostable mutant.
1. Virology - published August 3, 2022
2. Jayawardena N, McCarthy C, Wang I, Waqqar S, Burga LN, Strauss M, Bostina M
Cereblon covalent modulation through structure-based design of histidine targeting chemical probes.
1. RSC Chem Biol - published August 3, 2022
2. Cruite JT, Dann GP, Che J, Donovan KA, Ferrao S, Ficarro SB, Fischer ES, Gray NS, Huerta F, Kong NR, Liu H, Marto JA, Metivier RJ, Nowak RP, Zerfas BL, Jones LH
Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles.
1. Proc Natl Acad Sci U S A - published August 2, 2022
2. Syed AM, Ciling A, Taha TY, Chen IP, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Suryawanshi R, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Tabata T, Ott M, Doudna JA
Shelterin is a dimeric complex with extensive structural heterogeneity.
1. Proc Natl Acad Sci U S A - published August 2, 2022
2. Zinder JC, Olinares PDB, Svetlov V, Bush MW, Nudler E, Chait BT, Walz T, de Lange T
Golgi stress induces SIRT2 to counteract Shigella infection via defatty-acylation.
1. Nat Commun - published August 2, 2022
2. Wang M, Zhang Y, Komaniecki GP, Lu X, Cao J, Zhang M, Yu T, Hou D, Spiegelman NA, Yang M, Price IR, Lin H
Antibody binding increases the flexibility of the prion protein.
1. Biochim Biophys Acta Proteins Proteom - published August 2, 2022
2. Ilie IM, Caflisch A
Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change.
1. J Biol Chem - published August 2, 2022
2. Su Y, Iacob RE, Li J, Engen JR, Springer TA
Structural basis of mRNA maturation: Time to put it together.
1. Curr Opin Struct Biol - published August 2, 2022
2. Vorländer MK, Pacheco-Fiallos B, Plaschka C
Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter.
1. Proc Natl Acad Sci U S A - published August 2, 2022
2. Del Alamo D, DeSousa L, Nair RM, Rahman S, Meiler J, Mchaourab HS
On the formation of ordered protein assemblies in cell-cell interfaces.
1. Proc Natl Acad Sci U S A - published August 2, 2022
2. Boni N, Shapiro L, Honig B, Wu Y, Rubinstein R
Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair.
1. Proc Natl Acad Sci U S A - published August 2, 2022
2. Kim M, Kim HS, D'Souza A, Gallagher K, Jeong E, Topolska-Wós A, Ogorodnik Le Meur K, Tsai CL, Tsai MS, Kee M, Tainer JA, Yeo JE, Chazin WJ, Schärer OD
NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.
1. bioRxiv - published August 2, 2022
2. Simoneau CR, Chen PY, Xing GK, Khalid MM, Meyers NL, Hayashi JM, Taha TY, Leon KE, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose J, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M
Enantioselective Approach for Expanding the Three-Dimensional Space of Tetrahydroquinoline to Develop BET Bromodomain Inhibitors*.
1. Chemistry - published August 2, 2022
2. Lespinasse MA, Wei K, Perrin J, Winkler M, Hamaidia S, Leroy A, Jilkova ZM, Philouze C, Marche PN, Petosa C, Govin J, Emadali A, Wong YS
The Acyl-CoA Specificity of Human Lysine Acetyltransferase KAT2A.
1. Biochemistry - published August 2, 2022
2. Anmangandla A, Ren Y, Fu Q, Zhang S, Lin H
SPEACH_AF: Sampling protein ensembles and conformational heterogeneity with Alphafold2.
1. PLoS Comput Biol - published August 2, 2022
2. Stein RA, Mchaourab HS
Transcriptomic Data Sets for Zymomonas mobilis 2032 during Fermentation of Ammonia Fiber Expansion (AFEX)-Pretreated Corn Stover and Switchgrass Hydrolysates.
1. Microbiol Resour Announc - published August 2, 2022
2. Zhang Y, Myers KS, Place M, Serate J, Xie D, Pohlmann E, La Reau A, Landick R, Sato TK
Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis.
1. Nat Chem Biol - published August 2, 2022
2. Imai Y, Hauk G, Quigley J, Liang L, Son S, Ghiglieri M, Gates MF, Morrissette M, Shahsavari N, Niles S, Baldisseri D, Honrao C, Ma X, Guo JJ, Berger JM, Lewis K
Bifidobacterium animalis sup F1-7 Acts as an Effective Activator to Regulate Immune Response Via Casepase-3 and Bak of FAS/CD95 Pathway.
1. Probiotics Antimicrob Proteins - published August 2, 2022
2. Lu Y, Liang X, Wu Y, Wang R, Liu T, Yi H, Yu Z, Zhang Z, Gong P, Zhang L
Uropathogenic Escherichia coli subverts mitochondrial metabolism to enable intracellular bacterial pathogenesis in urinary tract infection.
1. Nat Microbiol - published August 2, 2022
2. Beebout CJ, Robertson GL, Reinfeld BI, Blee AM, Morales GH, Brannon JR, Chazin WJ, Rathmell WK, Rathmell JC, Gama V, Hadjifrangiskou M
De novo mutations in the BMP signaling pathway in lambdoid craniosynostosis.
1. Hum Genet - published August 2, 2022
2. Timberlake AT, Kiziltug E, Jin SC, Nelson-Williams C, Loring E, Yale Center for Genome Analysis., Allocco A, Marlier A, Banka S, Stuart H, Passos-Buenos MR, Rosa R, Rogatto SR, Tonne E, Stiegler AL, Boggon TJ, Alperovich M, Steinbacher D, Staffenberg DA, Flores RL, Persing JA, Kahle KT, Lifton RP
PI(4,5)P₂-stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt-β-catenin signaling.
1. Sci Signal - published August 2, 2022
2. Mahoney JP, Bruguera ES, Vasishtha M, Killingsworth LB, Kyaw S, Weis WI
Nanoscale 3D spatial addressing and valence control of quantum dots using wireframe DNA origami.
1. Nat Commun - published August 2, 2022
2. Chen C, Wei X, Parsons MF, Guo J, Banal JL, Zhao Y, Scott MN, Schlau-Cohen GS, Hernandez R, Bathe M
An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae.
1. Elife - published August 2, 2022
2. Kralt A, Wojtynek M, Fischer JS, Agote-Aran A, Mancini R, Dultz E, Noor E, Uliana F, Tatarek-Nossol M, Antonin W, Onischenko E, Medalia O, Weis K
Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex.
1. Nat Commun - published August 2, 2022
2. Foucher AE, Touat-Todeschini L, Juarez-Martinez AB, Rakitch A, Laroussi H, Karczewski C, Acajjaoui S, Soler-López M, Cusack S, Mackereth CD, Verdel A, Kadlec J
R-loop formation and conformational activation mechanisms of Cas9.
1. Nature - published August 2, 2022
2. Pacesa M, Loeff L, Querques I, Muckenfuss LM, Sawicka M, Jinek M
Redirecting the Neo-Substrate Specificity of Cereblon-Targeting PROTACs to Helios.
1. ACS Chem Biol - published August 2, 2022
2. Verano AL, You I, Donovan KA, Mageed N, Yue H, Nowak RP, Fischer ES, Wang ES, Gray NS
In situ single particle classification reveals distinct 60S maturation intermediates in cells.
1. Elife - published August 2, 2022
2. Lucas BA, Zhang K, Loerch S, Grigorieff N
Clinical characteristics of high myopia in female carriers of pathogenic RPGR mutations: a case series and review of the literature.
1. Ophthalmic Genet - published August 2, 2022
2. Tran M, Kolesnikova M, Kim AH, Kowal T, Ning K, Mahajan VB, Tsang SH, Sun Y
Structure and engineering of the minimal type VI CRISPR-Cas13bt3.
1. Mol Cell - published August 2, 2022
2. Nakagawa R, Kannan S, Altae-Tran H, Takeda SN, Tomita A, Hirano H, Kusakizako T, Nishizawa T, Yamashita K, Zhang F, Nishimasu H, Nureki O
Sending the message: specialized RNA export mechanisms in trypanosomes.
1. Trends Parasitol - published August 2, 2022
2. Obado SO, Rout MP, Field MC
Cryo-EM studies of membrane proteins at 200 keV.
1. Curr Opin Struct Biol - published August 2, 2022
2. Thangaratnarajah C, Rheinberger J, Paulino C
Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax1 PBM.
1. FEBS J - published August 2, 2022
2. Javorsky A, Maddumage JC, Mackie ERR, Soares da Costa TP, Humbert PO, Kvansakul M
IDPConformerGenerator: A Flexible Software Suite for Sampling the Conformational Space of Disordered Protein States.
1. J Phys Chem A - published August 2, 2022
2. Teixeira JMC, Liu ZH, Namini A, Li J, Vernon RM, Krzeminski M, Shamandy AA, Zhang O, Haghighatlari M, Yu L, Head-Gordon T, Forman-Kay JD
IL-2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor.
1. Am J Transplant - published August 2, 2022
2. Hirai T, Lin PY, Ramos TL, Simonetta F, Su LL, Picton LK, Baker J, Lohmeyer JK, Garcia KC, Negrin RS
Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma.
1. Sci Rep - published August 2, 2022
2. Napolitano V, Softley CA, Blat A, Kalel VC, Schorpp K, Siebenmorgen T, Hadian K, Erdmann R, Sattler M, Popowicz GM, Dubin G
US-align: universal structure alignments of proteins, nucleic acids, and macromolecular complexes.
1. Nat Methods - published August 2, 2022
2. Zhang C, Shine M, Pyle AM, Zhang Y
Innate type 2 immunity controls hair follicle commensalism by Demodex mites.
1. Immunity - published August 2, 2022
2. Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, Ansel KM, Spitzer MH, Liang HE, Locksley RM
Electron-counting MicroED data with the K2 and K3 direct electron detectors.
1. J Struct Biol - published August 2, 2022
2. Clabbers MTB, Martynowycz MW, Hattne J, Nannenga BL, Gonen T
Assessing PDB macromolecular crystal structure confidence at the individual amino acid residue level.
1. Structure - published August 2, 2022
2. Shao C, Bittrich S, Wang S, Burley SK
Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1.
1. Redox Biol - published August 2, 2022
2. Skoko JJ, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen CE, Ma H, Liu Y, Wu H, Furdui CM, Manevich Y, Morrison CG, Brown ET, Normolle D, Spies M, Spies MA, Carroll K, Neumann CA
Inactivation of the Complement Lectin Pathway by Candida tropicalis Secreted Aspartyl Protease-1.
1. Immunobiology - published August 2, 2022
2. Valand N, Brunt E, Gazioglu O, Yesilkaya H, Mitchell D, Horley N, Arroo R, Kishore U, Wallis R, Girija UV
Exploring the target scope of KEAP1 E3 ligase-based PROTACs.
1. Cell Chem Biol - published August 2, 2022
2. Du G, Jiang J, Henning NJ, Safaee N, Koide E, Nowak RP, Donovan KA, Yoon H, You I, Yue H, Eleuteri NA, He Z, Li Z, Huang HT, Che J, Nabet B, Zhang T, Fischer ES, Gray NS
Emerging roles of spliceosome in cancer and immunity.
1. Protein Cell - published August 1, 2022
2. Yang H, Beutler B, Zhang D
Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans.
1. Life Sci Alliance - published August 1, 2022
2. Stogios PJ, Liston SD, Semper C, Quade B, Michalska K, Evdokimova E, Ram S, Otwinowski Z, Borek D, Cowen LE, Savchenko A
Highly protective antimalarial antibodies via precision library generation and yeast display screening.
1. J Exp Med - published August 1, 2022
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Monoclonal antibodies binding data for SARS-CoV-2 proteins.
1. Data Brief - published August 1, 2022
2. Mishra N, Teyra J, Boytz R, Miersch S, Merritt TN, Cardarelli L, Gorelik M, Mihalic F, Jemth P, Davey RA, Sidhu SS, Leung DW, Amarasinghe GK
Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.
1. Proc Natl Acad Sci U S A - published August 1, 2022
2. Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
Akkermansia muciniphila phospholipid induces homeostatic immune responses.
1. Nature - published August 1, 2022
2. Bae M, Cassilly CD, Liu X, Park SM, Tusi BK, Chen X, Kwon J, Filipčík P, Bolze AS, Liu Z, Vlamakis H, Graham DB, Buhrlage SJ, Xavier RJ, Clardy J
Discovery of a drug to treat airway mucus hypersecretion.
1. Clin Transl Med - published August 1, 2022
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The Innate Immune Protein Calprotectin Interacts With and Encases Biofilm Communities of Pseudomonas aeruginosa and Staphylococcus aureus.
1. Front Cell Infect Microbiol - published August 1, 2022
2. Baishya J, Everett JA, Chazin WJ, Rumbaugh KP, Wakeman CA
A lipopolysaccharide-dependent phage infects a pseudomonad phytopathogen and can evolve to evade phage resistance.
1. Environ Microbiol - published August 1, 2022
2. Warring SL, Malone LM, Jayaraman J, Easingwood RA, Rigano LA, Frampton RA, Visnovsky SB, Addison SM, Hernandez L, Pitman AR, Lopez Acedo E, Kleffmann T, Templeton MD, Bostina M, Fineran PC
Mechanism of the cadherin-catenin F-actin catch bond interaction.
1. Elife - published August 1, 2022
2. Wang A, Dunn AR, Weis WI
Mechanism of client selection by the protein quality-control factor UBE2O.
1. Nat Struct Mol Biol - published August 1, 2022
2. Yip MCJ, Sedor SF, Shao S
The crystal structure of CbpD clarifies substrate-specificity motifs in chitin-active lytic polysaccharide monooxygenases.
1. Acta Crystallogr D Struct Biol - published August 1, 2022
2. Dade CM, Douzi B, Cambillau C, Ball G, Voulhoux R, Forest KT
Room-temperature serial synchrotron crystallography of Drosophila cryptochrome.
1. Acta Crystallogr D Struct Biol - published August 1, 2022
2. Schneps CM, Ganguly A, Crane BR
Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
1. J Biol Chem - published August 1, 2022
2. Yu Z, Chen J, Takagi E, Wang F, Saha B, Liu X, Joubert LM, Gleason CE, Jin M, Li C, Nowotny C, Agard D, Cheng Y, Pearce D
A Homozygous Missense Variant in KRT25 Underlying Overlapping Phenotype with Woolly Hair and Dental Anomalies.
1. J Invest Dermatol - published August 1, 2022
2. Raza R, Chhabra G, Bilal M, Ndiaye MA, Liaqat K, Nawaz S, Sgro JY, Rayment I, Ahmad W, Ahmad N
Crystal structures of glutamyl-tRNA synthetase from Elizabethkingia anopheles and E. meningosepticum.
1. Acta Crystallogr F Struct Biol Commun - published August 1, 2022
2. Brooks L, Subramanian S, Dranow DM, Mayclin SJ, Myler PJ, Asojo OA
Yeast PI31 inhibits the proteasome by a direct multisite mechanism.
1. Nat Struct Mol Biol - published August 1, 2022
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Engineered IL13 variants direct specificity of IL13Rα2-targeted CAR T cell therapy.
1. Proc Natl Acad Sci U S A - published August 1, 2022
2. Stern LA, Gholamin S, Moraga I, Yang X, Saravanakumar S, Cohen JR, Starr R, Aguilar B, Salvary V, Hibbard JC, Kalbasi A, Shepphird JK, O'Hearn J, Garcia KC, Brown CE
Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1.
1. Proc Natl Acad Sci U S A - published August 1, 2022
2. Schwarz MM, Price DA, Ganaie SS, Feng A, Mishra N, Hoehl RM, Fatma F, Stubbs SH, Whelan SPJ, Cui X, Egawa T, Leung DW, Amarasinghe GK, Hartman AL
System-wide analyses reveal essential roles of N-terminal protein modification in bacterial membrane integrity.
1. iScience - published August 1, 2022
2. Yang CI, Zhu Z, Jones JJ, Lomenick B, Chou TF, Shan SO
Durability of Heterologous and Homologous COVID-19 Vaccine Boosts.
1. JAMA Netw Open - published August 1, 2022
2. Tan CS, Collier AY, Yu J, Liu J, Chandrashekar A, McMahan K, Jacob-Dolan C, He X, Roy V, Hauser BM, Munt JE, Mallory ML, Mattocks M, Powers JM, Meganck RM, Rowe M, Hemond R, Bondzie EA, Jaegle KH, Baric RS, Schmidt AG, Alter G, Le Gars M, Sadoff J, Barouch DH
B-to-A transition in target DNA during retroviral integration.
1. Nucleic Acids Res - published August 1, 2022
2. Jóźwik IK, Li W, Zhang DW, Wong D, Grawenhoff J, Ballandras-Colas A, Aiyer S, Cherepanov P, Engelman AN, Lyumkis D
Molecular explorations of cancer biology and therapeutics at PDB-101.
1. Oncogene - published August 1, 2022
2. Goodsell DS, Dutta S, Voigt M, Zardecki C, Burley SK
Molecular architecture of bacterial type IV secretion systems.
1. PLoS Pathog - published August 1, 2022
2. Sheedlo MJ, Ohi MD, Lacy DB, Cover TL
Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor.
1. ACS Chem Biol - published August 1, 2022
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Prokaryotic innate immunity through pattern recognition of conserved viral proteins.
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2. Gao LA, Wilkinson ME, Strecker J, Makarova KS, Macrae RK, Koonin EV, Zhang F
An Antibody from Single Human V_H-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion.
1. Sci Immunol - published August 1, 2022
2. Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
A haem-sequestering plant peptide promotes iron uptake in symbiotic bacteria.
1. Nat Microbiol - published August 1, 2022
2. Sankari S, Babu VMP, Bian K, Alhhazmi A, Andorfer MC, Avalos DM, Smith TA, Yoon K, Drennan CL, Yaffe MB, Lourido S, Walker GC
Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease M^pro and Papain-like Protease PL^pro of SARS-CoV-2.
1. J Chem Inf Model - published August 1, 2022
2. Santos LH, Kronenberger T, Almeida RG, Silva EB, Rocha REO, Oliveira JC, Barreto LV, Skinner D, Fajtová P, Giardini MA, Woodworth B, Bardine C, Lourenço AL, Craik CS, Poso A, Podust LM, McKerrow JH, Siqueira-Neto JL, O'Donoghue AJ, da Silva Júnior EN, Ferreira RS
A naturally arising broad and potent CD4-binding site antibody with low somatic mutation.
1. Sci Adv - published August 1, 2022
2. Barnes CO, Schoofs T, Gnanapragasam PNP, Golijanin J, Huey-Tubman KE, Gruell H, Schommers P, Suh-Toma N, Lee YE, Cetrulo Lorenzi JC, Piechocka-Trocha A, Scheid JF, West AP Jr, Walker BD, Seaman MS, Klein F, Nussenzweig MC, Bjorkman PJ
Reproductive Ophthalmology: The Intersection of Inherited Eye Diseases and Reproductive Technologies.
1. Retina - published August 1, 2022
2. Park JG, Xu CL, Boyd A, Aghajanova L, Mahajan VB, Wood EH
Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the ATF4 stress response and identification of Sirt5 as a key ATF4 effector.
1. Cell Death Discov - published August 1, 2022
2. Li R, Wilson KF, Cerione RA
Disulfide-crosslink analysis of the ubiquitin ligase Hrd1 complex during endoplasmic reticulum-associated protein degradation.
1. J Biol Chem - published August 1, 2022
2. Pisa R, Rapoport TA
Bps polysaccharide of Bordetella pertussis resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts Escherichia coli into a respiratory pathogen.
1. PLoS Pathog - published August 1, 2022
2. Fullen AR, Gutierrez-Ferman JL, Yount KS, Love CF, Choi HG, Vargas MA, Raju D, Corps KN, Howell PL, Dubey P, Deora R
Microfluidic-Derived Detection of Protein-Facilitated Copper Flux Across Lipid Membranes.
1. Anal Chem - published August 1, 2022
2. Górecki K, Hansen JS, Li P, Nayeri N, Lindkvist-Petersson K, Gourdon P
PH domain-mediated autoinhibition and oncogenic activation of Akt.
1. Elife - published August 1, 2022
2. Bae H, Viennet T, Park E, Chu N, Salguero A, Eck MJ, Arthanari H, Cole PA
A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA.
1. Commun Biol - published August 1, 2022
2. Pham VV, Gao M, Meagher JL, Smith JL, D'Souza VM
Author Correction: A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes.
1. Nat Commun - published August 1, 2022
2. Coelho CH, Tang WK, Burkhardt M, Galson JD, Muratova O, Salinas ND, Alves E Silva TL, Reiter K, MacDonald NJ, Nguyen V, Herrera R, Shimp R, Narum DL, Byrne-Steele M, Pan W, Hou X, Brown B, Eisenhower M, Han J, Jenkins BJ, Doritchamou JYA, Smelkinson MG, Vega-Rodríguez J, Trück J, Taylor JJ, Sagara I, Healy SA, Renn JP, Tolia NH, Duffy PE
Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle.
1. Nat Commun - published August 1, 2022
2. Jenni S, Horwitz JA, Bloyet LM, Whelan SPJ, Harrison SC
SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP.
1. Nat Commun - published August 1, 2022
2. Chau JE, Vish KJ, Boggon TJ, Stiegler AL
Hydroxamic Acid-Modified Peptide Library Provides Insights into the Molecular Basis for the Substrate Selectivity of HDAC Corepressor Complexes.
1. ACS Chem Biol - published August 1, 2022
2. Archibald LJ, Brown EA, Millard CJ, Watson PJ, Robertson NS, Wang S, Schwabe JWR, Jamieson AG
Stitching and registering highly multiplexed whole slide images of tissues and tumors using ASHLAR.
1. Bioinformatics - published August 1, 2022
2. Muhlich JL, Chen YA, Yapp C, Russell D, Santagata S, Sorger PK
Conformation and Pairing Properties of an O⁶-Methyl-2'-deoxyguanosine-Directed Benzimidazole Nucleoside Analog in Duplex DNA.
1. Chem Res Toxicol - published August 1, 2022
2. Kellum AH Jr, Pallan PS, Nilforoushan A, Sturla SJ, Stone MP, Egli M
Integrative model of the FSH receptor reveals the structural role of the flexible hinge region.
1. Structure - published August 1, 2022
2. Nagel M, Moretti R, Paschke R, von Bergen M, Meiler J, Kalkhof S
Herpes Simplex Virus 1 Entry Glycoproteins Form Complexes before and during Membrane Fusion.
1. mBio - published August 1, 2022
2. Pataki Z, Rebolledo Viveros A, Heldwein EE
A Chemical Approach to Introduce 2,6-Diaminopurine and 2-Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups.
1. Org Lett - published August 1, 2022
2. Madaoui M, Datta D, Wassarman K, Zlatev I, Egli M, Ross BS, Manoharan M
Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma.
1. Nat Commun - published August 1, 2022
2. Coy S, Wang S, Stopka SA, Lin JR, Yapp C, Ritch CC, Salhi L, Baker GJ, Rashid R, Baquer G, Regan M, Khadka P, Cole KA, Hwang J, Wen PY, Bandopadhayay P, Santi M, De Raedt T, Ligon KL, Agar NYR, Sorger PK, Touat M, Santagata S
Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin.
1. Cell Rep - published August 1, 2022
2. Goldsmith JA, DiVenere AM, Maynard JA, McLellan JS
Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses.
1. Immunity - published August 1, 2022
2. McLeod B, Mabrouk MT, Miura K, Ravichandran R, Kephart S, Hailemariam S, Pham TP, Semesi A, Kucharska I, Kundu P, Huang WC, Johnson M, Blackstone A, Pettie D, Murphy M, Kraft JC, Leaf EM, Jiao Y, van de Vegte-Bolmer M, van Gemert GJ, Ramjith J, King CR, MacGill RS, Wu Y, Lee KK, Jore MM, King NP, Lovell JF, Julien JP
Endocytosis in the axon initial segment maintains neuronal polarity.
1. Nature - published August 1, 2022
2. Eichel K, Uenaka T, Belapurkar V, Lu R, Cheng S, Pak JS, Taylor CA, Südhof TC, Malenka R, Wernig M, Özkan E, Perrais D, Shen K
Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs.
1. Nat Commun - published August 1, 2022
2. Tucker K, Sridharan S, Adesnik H, Brohawn SG
Double NPY motifs at the N-terminus of the yeast t-SNARE Sso2 synergistically bind Sec3 to promote membrane fusion.
1. Elife - published August 1, 2022
2. Peer M, Yuan H, Zhang Y, Korbula K, Novick P, Dong G
RNA-Dependent RNA Polymerase of the Second Human Pegivirus Exhibits a High-Fidelity Feature.
1. Microbiol Spectr - published August 1, 2022
2. Chen S, Wu J, Yang X, Sun Q, Liu S, Rashid F, Dzakah EE, Wang H, Wang J, Gong P, Tang S
Characterization of Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Variants Selected for Resistance to a CD4-Mimetic Compound.
1. J Virol - published August 1, 2022
2. Anang S, Richard J, Bourassa C, Goyette G, Chiu TJ, Chen HC, Smith AB 3rd, Madani N, Finzi A, Sodroski J
Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine.
1. iScience - published August 1, 2022
2. Aslanoglou D, Bertera S, Friggeri L, Sánchez-Soto M, Lee J, Xue X, Logan RW, Lane JR, Yechoor VK, McCormick PJ, Meiler J, Free RB, Sibley DR, Bottino R, Freyberg Z
PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes.
1. Sci Immunol - published August 1, 2022
2. Clement CC, Osan J, Buque A, Nanaware PP, Chang YC, Perino G, Shetty M, Yamazaki T, Tsai WL, Urbanska AM, Calvo-Calle JM, Ramsamooj S, Ramsamooj S, Vergani D, Mieli-Vergani G, Terziroli Beretta-Piccoli B, Gadina M, Montagna C, Goncalves MD, Sallusto F, Galluzzi L, Soni RK, Stern LJ, Santambrogio L
Catching BETs by viruses.
1. Biochim Biophys Acta Gene Regul Mech - published August 1, 2022
2. Zandian M, Chen IP, Byrareddy SN, Fujimori DG, Ott M, Kutateladze TG
Targeting protein conformations with small molecules to control protein complexes.
1. Trends Biochem Sci - published August 1, 2022
2. Zacharioudakis E, Gavathiotis E
Structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8.
1. J Mol Biol - published August 1, 2022
2. Farhat D, Rezaei F, Ristovski M, Yang Y, Stancescu A, Dzimkova L, Samnani S, Couture JF, Lee JY
Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization.
1. iScience - published August 1, 2022
2. Patten JJ, Keiser PT, Morselli-Gysi D, Menichetti G, Mori H, Donahue CJ, Gan X, Valle ID, Geoghegan-Barek K, Anantpadma M, Boytz R, Berrigan JL, Stubbs SH, Ayazika T, O'Leary C, Jalloh S, Wagner F, Ayehunie S, Elledge SJ, Anderson D, Loscalzo J, Zitnik M, Gummuluru S, Namchuk MN, Barabási AL, Davey RA
Production of Eukaryotic Glycoproteins for Structural and Functional Studies Using Expi293F Cells.
1. Curr Protoc - published August 1, 2022
2. Greven JA, Brett TJ
Recent advances in wearable medical diagnostic sensors and new therapeutic dosage forms for fever in children.
1. J Pharm Biomed Anal - published August 1, 2022
2. Liu X, Huang S, Ma L, Ye H, Lin J, Cai X, Shang Q, Zheng C, Xu R, Zhang D
An Interpretable Machine-Learning Algorithm to Predict Disordered Protein Phase Separation Based on Biophysical Interactions.
1. Biomolecules - published August 1, 2022
2. Cai H, Vernon RM, Forman-Kay JD
Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity.
1. Eur J Med Chem - published August 1, 2022
2. Pang AH, Green KD, Chandrika NT, Garzan A, Punetha A, Holbrook SYL, Willby MJ, Posey JE, Tsodikov OV, Garneau-Tsodikova S
Antigen-guided depletion of anti-HLA antibody-producing cells by HLA-Fc fusion proteins.
1. Blood - published August 1, 2022
2. Webber AM, Bradstreet TR, Wang X, Guo H, Nelson CA, Fremont DH, Edelson BT, Liu C