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123 Member Publications for September 2022

Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants.
1. Front Immunol - published September 29, 2022
2. Li Q, Humphries F, Girardin RC, Wallace A, Ejemel M, Amcheslavsky A, McMahon CT, Schiller ZA, Ma Z, Cruz J, Dupuis AP, Payne AF, Maryam A, Yilmaz NK, McDonough KA, Pierce BG, Schiffer CA, Kruse AC, Klempner MS, Cavacini LA, Fitzgerald KA, Wang Y
Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development.
1. Front Mol Biosci - published September 23, 2022
2. Wareham LK, Whitener AE, Wu HJ, Wu SY, Mchaourab HS, Mortlock DP, Kuchtey RW, Kuchtey J
T Stage and Pretreatment Standardized Uptake Values Predict Tumor Recurrence With 5-Fraction SABR in Early-Stage Non-Small Cell Lung Cancer.
1. Adv Radiat Oncol - published September 23, 2022
2. Hsu EJ, Mendel JT, Ward KA, El-Ashmawy M, Lee M, Choy H, Westover KD, Vo DT, Timmerman RD, Sher DJ, Iyengar P
Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens.
1. Front Immunol - published September 19, 2022
2. de Souza MO, Madan B, Teng IT, Huang A, Liu L, Fahad AS, Lopez Acevedo SN, Pan X, Sastry M, Gutierrez-Gonzalez M, Yin MT, Zhou T, Ho DD, Kwong PD, DeKosky BJ
Practical method for RF pulse distortion compensation using multiple square pulses for low-field MRI.
1. PLoS One - published September 16, 2022
2. Ha Y, Selvaganesan K, Wu B, Hancock K, Rogers C 3rd, Hosseinnezhadian S, Galiana G, Constable RT
Case Report: Resolution of radiation pneumonitis with androgens and growth hormone.
1. Front Oncol - published September 12, 2022
2. Yen A, Westover KD
Conserved FimH mutations in the global Escherichia coli ST131 multi-drug resistant lineage weaken interdomain interactions and alter adhesin function.
1. Comput Struct Biotechnol J - published September 12, 2022
2. Qin J, Wilson KA, Sarkar S, Heras B, O'Mara ML, Totsika M
Coevolution of the Ess1-CTD axis in polar fungi suggests a role for phase separation in cold tolerance.
1. Sci Adv - published September 9, 2022
2. Palumbo RJ, McKean N, Leatherman E, Namitz KEW, Connell L, Wolfe A, Moody K, Gostinčar C, Gunde-Cimerman N, Bah A, Hanes SD
A two-step mechanism governing PARP1-DNA retention by PARP inhibitors.
1. Sci Adv - published September 9, 2022
2. Xue H, Bhardwaj A, Yin Y, Fijen C, Ephstein A, Zhang L, Ding X, Pascal JM, VanArsdale TL, Rothenberg E
Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis.
1. Elife - published September 8, 2022
2. Muckenfuss LM, Migenda Herranz AC, Boneberg FM, Clerici M, Jinek M
Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins.
1. Science - published September 8, 2022
2. Pechincha C, Groessl S, Kalis R, de Almeida M, Zanotti A, Wittmann M, Schneider M, de Campos RP, Rieser S, Brandstetter M, Schleiffer A, Müller-Decker K, Helm D, Jabs S, Haselbach D, Lemberg MK, Zuber J, Palm W
Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3.
1. Nat Commun - published September 8, 2022
2. Peters CE, Schulze-Gahmen U, Eckhardt M, Jang GM, Xu J, Pulido EH, Bardine C, Craik CS, Ott M, Gozani O, Verba KA, Hüttenhain R, Carette JE, Krogan NJ
Techno-ecological synergies of hydropower plants: Insights from GHG mitigation.
1. Sci Total Environ - published September 8, 2022
2. Liu X, Zheng X, Wu L, Deng S, Pan H, Zhou J, Zhang X, Luo Y
How An Assembly Factor Enhances Covalent FAD Attachment to the Flavoprotein Subunit of Complex II.
1. J Biol Chem - published September 8, 2022
2. Maklashina E, Iverson TM, Cecchini G
Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing.
1. ACS Med Chem Lett - published September 8, 2022
2. Dalle Vedove A, Cazzanelli G, Batiste L, Marchand JR, Spiliotopoulos D, Corsi J, D'Agostino VG, Caflisch A, Lolli G
Fragment Ligands of the m⁶A-RNA Reader YTHDF2.
1. ACS Med Chem Lett - published September 8, 2022
2. Nai F, Nachawati R, Zálešák F, Wang X, Li Y, Caflisch A
Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection.
1. Sci Transl Med - published September 7, 2022
2. Saunders KO, Edwards RJ, Tilahun K, Manne K, Lu X, Cain DW, Wiehe K, Williams WB, Mansouri K, Hernandez GE, Sutherland L, Scearce R, Parks R, Barr M, DeMarco T, Eater CM, Eaton A, Morton G, Mildenberg B, Wang Y, Rountree RW, Tomai MA, Fox CB, Moody MA, Alam SM, Santra S, Lewis MG, Denny TN, Shaw GM, Montefiori DC, Acharya P, Haynes BF
Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B.
1. PLoS Comput Biol - published September 7, 2022
2. Orädd F, Steffen JH, Gourdon P, Andersson M
Transcriptional Plasticity Drives Leukemia Immune Escape.
1. Blood Cancer Discov - published September 6, 2022
2. Eagle K, Harada T, Kalfon J, Perez MW, Heshmati Y, Ewers J, Koren JV, Dempster JM, Kugener G, Paralkar VR, Lin CY, Dharia NV, Stegmaier K, Orkin SH, Pimkin M
USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer.
1. Proc Natl Acad Sci U S A - published September 6, 2022
2. Xie H, Zhou J, Liu X, Xu Y, Hepperla AJ, Simon JM, Wang T, Yao H, Liao C, Baldwin AS, Gong K, Zhang Q
Mapping the per-residue surface electrostatic potential of CAPRIN1 along its phase-separation trajectory.
1. Proc Natl Acad Sci U S A - published September 6, 2022
2. Toyama Y, Rangadurai AK, Forman-Kay JD, Kay LE
Nanobodies identify an activated state of the TRIB2 pseudokinase.
1. Structure - published September 6, 2022
2. Jamieson SA, Pudjihartono M, Horne CR, Viloria JS, Dunlop JL, McMillan HD, Day RC, Keeshan K, Murphy JM, Mace PD
Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity.
1. Viruses - published September 6, 2022
2. Barzak FM, Ryan TM, Mohammadzadeh N, Harjes S, Kvach MV, Kurup HM, Krause KL, Chelico L, Filichev VV, Harjes E, Jameson GB
Cryo-EM reveals local and global structural rearrangements in RYR mutants.
1. J Gen Physiol - published September 5, 2022
2. Iyer KA, Hu Y, Klose T, Murayama T, Samsó M
Biophysical characterisation of the Bcl-x pre-mRNA and binding specificity of the ellipticine derivative GQC-05: Implication for alternative splicing regulation.
1. Front Mol Biosci - published September 5, 2022
2. Bhogadia M, Stone B, Del Villar Guerra R, Muskett FW, Ghosh S, Taladriz-Sender A, Burley GA, Eperon IC, Hudson AJ, Dominguez C
Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns.
1. Nat Commun - published September 5, 2022
2. Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Lyu W, Zhu L, van Zundert GCP, Robertson MJ, Skiniotis G, Du Y, Hu H, Ye RD
Ectopic JAK-STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance.
1. Nat Cancer - published September 5, 2022
2. Deng S, Wang C, Wang Y, Xu Y, Li X, Johnson NA, Mukherji A, Lo UG, Xu L, Gonzalez J, Metang LA, Ye J, Tirado CR, Rodarte K, Zhou Y, Xie Z, Arana C, Annamalai V, Liu X, Vander Griend DJ, Strand D, Hsieh JT, Li B, Raj G, Wang T, Mu P
A Prosperous Future.
1. J Biochem - published September 5, 2022
2. Lemmon MA
A bead-based method for high-throughput mapping of the sequence- and force-dependence of T cell activation.
1. Nat Methods - published September 5, 2022
2. Feng Y, Zhao X, White AK, Garcia KC, Fordyce PM
Oncometabolite d-2HG alters T cell metabolism to impair CD8⁺ T cell function.
1. Science - published September 3, 2022
2. Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, Zaganjor E, McBrayer SK, Sorger PK, Sharpe AH, Wucherpfennig KW, Santagata S, Agar NYR, Suvà ML, Haigis MC
Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.
1. Elife - published September 3, 2022
2. Siepe DH, Henneberg LT, Wilson SC, Hess GT, Bassik MC, Zinn K, Garcia KC
Structural analysis of human CEACAM1 oligomerization.
1. Commun Biol - published September 3, 2022
2. Gandhi AK, Sun ZJ, Huang YH, Kim WM, Yang C, Petsko GA, Beauchemin N, Blumberg RS
GroovDB: A Database of Ligand-Inducible Transcription Factors.
1. ACS Synth Biol - published September 3, 2022
2. d'Oelsnitz S, Love JD, Diaz DJ, Ellington AD
Single-chain Insulin Analogs Threaded by the Insulin Receptor αCT Domain.
1. Biophys J - published September 3, 2022
2. Smith NA, Menting JG, Weiss MA, Lawrence MC, Smith BJ
Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants.
1. Cell Rep - published September 3, 2022
2. Chen Z, Zhang P, Matsuoka Y, Tsybovsky Y, West K, Santos C, Boyd LF, Nguyen H, Pomerenke A, Stephens T, Olia AS, Zhang B, De Giorgi V, Holbrook MR, Gross R, Postnikova E, Garza NL, Johnson RF, Margulies DH, Kwong PD, Alter HJ, Buchholz UJ, Lusso P, Farci P
Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange.
1. Blood - published September 2, 2022
2. Anderson JR, Li J, Springer TA, Brown A
Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex.
1. Sci Adv - published September 2, 2022
2. Bous J, Fouillen A, Orcel H, Trapani S, Cong X, Fontanel S, Saint-Paul J, Lai-Kee-Him J, Urbach S, Sibille N, Sounier R, Granier S, Mouillac B, Bron P
Dynamic Protein-RNA recognition in primary MicroRNA processing.
1. Curr Opin Struct Biol - published September 2, 2022
2. Ruiz-Arroyo VM, Nam Y
Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study.
1. Lancet Respir Med - published September 2, 2022
2. Solomon JJ, Danoff SK, Woodhead FA, Hurwitz S, Maurer R, Glaspole I, Dellaripa PF, Gooptu B, Vassallo R, Cox PG, Flaherty KR, Adamali HI, Gibbons MA, Troy L, Forrest IA, Lasky JA, Spencer LG, Golden J, Scholand MB, Chaudhuri N, Perrella MA, Lynch DA, Chambers DC, Kolb M, Spino C, Raghu G, Goldberg HJ, Rosas IO, TRAIL1 Network Investigators.
Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.
1. Neuron - published September 2, 2022
2. Cao C, Barros-Álvarez X, Zhang S, Kim K, Dämgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Hüttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL
Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome.
1. Proc Natl Acad Sci U S A - published September 2, 2022
2. Rahman S, Hoffmann NA, Worden EJ, Smith ML, Namitz KEW, Knutson BA, Cosgrove MS, Wolberger C
Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex.
1. Proc Natl Acad Sci U S A - published September 2, 2022
2. Bernardes NE, Fung HYJ, Li Y, Chen Z, Chook YM
Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors.
1. Eur J Med Chem - published September 2, 2022
2. Gannam ZTK, Jamali H, Kweon OS, Herrington J, Shillingford SR, Papini C, Gentzel E, Lolis E, Bennett AM, Ellman JA, Anderson KS
Patch Testing With Nickel Sulfate 5.0% Traces Significantly More Contact Allergy Than 2.5%: A Prospective Study Within the International Contact Dermatitis Research Group.
1. Dermatitis - published September 2, 2022
2. Svedman C, Ale I, Goh CL, Goncalo M, Lee JY, Ljubojevic Hadžavdić S, Matsunaga K, Bach RO, Pratt M, Puangpet P, Sasseville D, Andersen KE, Dahlin J, Suzuki K, Yagami A, Bruze M
Kinesin-1, -2 and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport.
1. Elife - published September 2, 2022
2. Gicking AM, Ma TC, Feng Q, Jiang R, Badieyan S, Cianfrocco MA, Hancock WO
The HIV-1 protein Nef activates the Tec family kinase Btk by stabilizing an intermolecular SH3-SH2 domain interaction.
1. Sci Signal - published September 2, 2022
2. Aryal M, Lin D, Regan K, Du S, Shi H, Alvarado JJ, Ilina TV, Andreotti AH, Smithgall TE
Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.
1. J Med Chem - published September 2, 2022
2. Bubenik M, Mader P, Mochirian P, Vallée F, Clark J, Truchon JF, Perryman AL, Pau V, Kurinov I, Zahn KE, Leclaire ME, Papp R, Mathieu MC, Hamel M, Duffy NM, Godbout C, Casas-Selves M, Falgueyret JP, Baruah PS, Nicolas O, Stocco R, Poirier H, Martino G, Fortin AB, Roulston A, Chefson A, Dorich S, St-Onge M, Patel P, Pellerin C, Ciblat S, Pinter T, Barabé F, El Bakkouri M, Parikh P, Gervais C, Sfeir A, Mamane Y, Morris SJ, Black WC, Sicheri F, Gallant M
The Sialyl Lewis X Glycan Receptor Facilitates Infection of Subtype H7 Avian Influenza A Viruses.
1. J Virol - published September 2, 2022
2. Guan M, Olivier AK, Lu X, Epperson W, Zhang X, Zhong L, Waters K, Mamaliger N, Li L, Wen F, Tao YJ, DeLiberto TJ, Wan XF
Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirus.
1. Cell Rep - published September 2, 2022
2. Rush SA, Brar G, Hsieh CL, Chautard E, Rainho-Tomko JN, Slade CD, Bricault CA, Kume A, Kearns J, Groppo R, Mundle ST, Zhang L, Casimiro D, Fu TM, DiNapoli JM, McLellan JS
Investigating the Impact of Polymer Length, Attachment Site, and Charge on Enzymatic Activity and Stability of Cellulase.
1. Biomacromolecules - published September 2, 2022
2. Wright TA, Bennett C, Johnson MR, Fischesser H, Chandrarathne BM, Ram N, Maloof E, Tyler A, Upshaw CR, Stewart JM, Page RC, Konkolewicz D
Emerging principles of cytokine pharmacology and therapeutics.
1. Nat Rev Drug Discov - published September 2, 2022
2. Saxton RA, Glassman CR, Garcia KC
Structural Insights into Microbial One-Carbon Metabolic Enzymes Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenases and Acetyl-CoA Synthases.
1. Biochemistry - published September 2, 2022
2. Biester A, Marcano-Delgado AN, Drennan CL
Neutralizing immunity induced against the Omicron BA.1 and BA.2 variants in vaccine breakthrough infections.
1. J Infect Dis - published September 2, 2022
2. Brazer N, Morris MK, Servellita V, Anglin K, Saldhi P, Garcia-Knight M, Bethancourt S, Sotomayor-Gonzalez A, Wang B, Foresythe A, Nguyen J, Gliwa AS, Pineda-Ramirez J, Sanchez RD, Zhang Y, Ott M, Wadford DA, Andino R, Kelly JD, Hanson C, Chiu C
Engineered LwaCas13a with enhanced collateral activity for nucleic acid detection.
1. Nat Chem Biol - published September 2, 2022
2. Yang J, Song Y, Deng X, Vanegas JA, You Z, Zhang Y, Weng Z, Avery L, Dieckhaus KD, Peddi A, Gao Y, Zhang Y, Gao X
Interactions of Curcumin's Degradation Products with the Aβ₄₂ Dimer: A Computational Study.
1. J Phys Chem B - published September 2, 2022
2. Dehabadi MH, Caflisch A, Ilie IM, Firouzi R
Detection of biomarkers for filoviral infection with a silicon photonic resonator platform.
1. STAR Protoc - published September 2, 2022
2. Meserve K, Qavi AJ, Aman MJ, Vu H, Zeitlin L, Dye JM, Froude JW, Leung DW, Yang L, Holtsberg FW, Amarasinghe GK, Bailey RC
Structure and Specificity of an Anti-Chloramphenicol Single Domain Antibody for Detection of Amphenicol Residues.
1. Protein Sci - published September 2, 2022
2. Swofford CA, Nordeen SA, Chen L, Desai MM, Chen J, Springs SL, Schwartz TU, Sinskey AJ
Enterovirus D68 Infection in Human Primary Airway and Brain Organoids: No Additional Role for Heparan Sulfate Binding for Neurotropism.
1. Microbiol Spectr - published September 2, 2022
2. Sridhar A, Depla JA, Mulder LA, Karelehto E, Brouwer L, Kruiswijk L, Vieira de Sá R, Meijer A, Evers MM, van Kuppeveld FJM, Pajkrt D, Wolthers KC
Comparative sequence analysis of vitamin K-dependent coagulation factors.
1. J Thromb Haemost - published September 2, 2022
2. Stojanovski BM, Di Cera E
Computational identification of a systemic antibiotic for gram-negative bacteria.
1. Nat Microbiol - published September 2, 2022
2. Miller RD, Iinishi A, Modaresi SM, Yoo BK, Curtis TD, Lariviere PJ, Liang L, Son S, Nicolau S, Bargabos R, Morrissette M, Gates MF, Pitt N, Jakob RP, Rath P, Maier T, Malyutin AG, Kaiser JT, Niles S, Karavas B, Ghiglieri M, Bowman SEJ, Rees DC, Hiller S, Lewis K
Protein-imprinted particles for coronavirus capture from solution.
1. J Sep Sci - published September 2, 2022
2. Senehi NL, Ykema MR, Sun R, Verduzco R, Stadler LB, Tao YJ, Alvarez PJJ
Induced CD45 Proximity Potentiates Natural Killer Cell Receptor Antagonism.
1. ACS Synth Biol - published September 2, 2022
2. Ren J, Jo Y, Picton LK, Su LL, Raulet DH, Garcia KC
Reflections on Integrins-Past, Present, and Future: The Albert Lasker Basic Medical Research Award.
1. JAMA - published September 2, 2022
2. Hynes RO, Ruoslahti E, Springer TA
Bespoke library docking for 5-HT_2A receptor agonists with antidepressant activity.
1. Nature - published September 2, 2022
2. Kaplan AL, Confair DN, Kim K, Barros-Álvarez X, Rodriguiz RM, Yang Y, Kweon OS, Che T, McCorvy JD, Kamber DN, Phelan JP, Martins LC, Pogorelov VM, DiBerto JF, Slocum ST, Huang XP, Kumar JM, Robertson MJ, Panova O, Seven AB, Wetsel AQ, Wetsel WC, Irwin JJ, Skiniotis G, Shoichet BK, Roth BL, Ellman JA
Unravelling the role of transient redox partner complexes in P450 electron transfer mechanics.
1. Sci Rep - published September 2, 2022
2. Hargrove TY, Lamb DC, Smith JA, Wawrzak Z, Kelly SL, Lepesheva GI
Developmental dynamics of RNA translation in the human brain.
1. Nat Neurosci - published September 2, 2022
2. Duffy EE, Finander B, Choi G, Carter AC, Pritisanac I, Alam A, Luria V, Karger A, Phu W, Sherman MA, Assad EG, Pajarillo N, Khitun A, Crouch EE, Ganesh S, Chen J, Berger B, Sestan N, O'Donnell-Luria A, Huang EJ, Griffith EC, Forman-Kay JD, Moses AM, Kalish BT, Greenberg ME
Improved mammalian retromer cryo-EM structures reveal a new assembly interface.
1. J Biol Chem - published September 2, 2022
2. Kendall AK, Chandra M, Xie B, Wan W, Jackson LP
Viruses inhibit TIR gcADPR signaling to overcome bacterial defense.
1. Nature - published September 2, 2022
2. Leavitt A, Yirmiya E, Amitai G, Lu A, Garb J, Herbst E, Morehouse BR, Hobbs SJ, Antine SP, Sun ZJ, Kranzusch PJ, Sorek R
Complete Genome Sequence of the Uropathogenic Methicillin-Resistant Staphylococcus aureus Strain MRSA-1369.
1. Microbiol Resour Announc - published September 2, 2022
2. Tükenmez H, Nye TM, Bonde M, Caparon MG, Almqvist F, Hultgren SJ, Johansson J
Spatiotemporal organisation of protein processing in the kidney.
1. Nat Commun - published September 2, 2022
2. Polesel M, Kaminska M, Haenni D, Bugarski M, Schuh C, Jankovic N, Kaech A, Mateos JM, Berquez M, Hall AM
Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
1. Nat Struct Mol Biol - published September 2, 2022
2. Bonsor DA, Alexander P, Snead K, Hartig N, Drew M, Messing S, Finci LI, Nissley DV, McCormick F, Esposito D, Rodriguez-Viciana P, Stephen AG, Simanshu DK
High-throughput approaches to understand and engineer bacteriophages.
1. Trends Biochem Sci - published September 2, 2022
2. Huss P, Chen J, Raman S
A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM.
1. STAR Protoc - published September 2, 2022
2. Zhang K, Julius D, Cheng Y
Access and utilization of long chain fatty acyl-CoA by zDHHC protein acyltransferases.
1. Curr Opin Struct Biol - published September 2, 2022
2. Puthenveetil R, Gómez-Navarro N, Banerjee A
A review: Pharmacokinetics and pharmacology of aminoalcohol-diterpenoid alkaloids from Aconitum species.
1. J Ethnopharmacol - published September 2, 2022
2. Tao H, Liu X, Tian R, Liu Y, Zeng Y, Meng X, Zhang Y
Tryptophan mutations in G3BP1 tune the stability of a cellular signaling hub by weakening transient interactions with Caprin1 and USP10.
1. J Biol Chem - published September 2, 2022
2. Sheehan CT, Hampton TH, Madden DR
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.
1. Eur J Med Chem - published September 2, 2022
2. Napolitano V, Mróz P, Marciniak M, Kalel VC, Softley CA, Janna Olmos JD, Tippler BG, Schorpp K, Rioton S, Fröhlich T, Plettenburg O, Hadian K, Erdmann R, Sattler M, Popowicz GM, Dawidowski M, Dubin G
Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy.
1. Int J Mol Sci - published September 2, 2022
2. Zhang Y, Wang Y, Uslu S, Venkatachalapathy S, Rashidian M, Schaefer JV, Plückthun A, Distefano MD
Unorthodox PCNA Binding by Chromatin Assembly Factor 1.
1. Int J Mol Sci - published September 2, 2022
2. Gopinathan Nair A, Rabas N, Lejon S, Homiski C, Osborne MJ, Cyr N, Sverzhinsky A, Melendy T, Pascal JM, Laue ED, Borden KLB, Omichinski JG, Verreault A
Interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses.
1. Cell - published September 2, 2022
2. Buckner CM, Kardava L, El Merhebi O, Narpala SR, Serebryannyy L, Lin BC, Wang W, Zhang X, Lopes de Assis F, Kelly SEM, Teng IT, McCormack GE, Praiss LH, Seamon CA, Rai MA, Kalish H, Kwong PD, Proschan MA, McDermott AB, Fauci AS, Chun TW, Moir S
The Multicellular Effects of VDAC1 N-Terminal-Derived Peptide.
1. Biomolecules - published September 2, 2022
2. Anand U, Shteinfer-Kuzmine A, Sela G, Santhanam M, Gottschalk B, Boujemaa-Paterski R, Medalia O, Graier WF, Shoshan-Barmatz V
Assessment of nucleotide/nucleoside analog intervention in primer-dependent viral RNA-dependent RNA polymerases.
1. STAR Protoc - published September 1, 2022
2. Liu Q, Wu J, Gong P
Herpes simplex virus lymphadenitis is associated with tumor reduction in a patient with chronic lymphocytic leukemia.
1. J Clin Invest - published September 1, 2022
2. Chang A, Sholukh AM, Wieland A, Jaye DL, Carrington M, Huang ML, Xie H, Jerome KR, Roychoudhury P, Greninger AL, Koff JL, Cohen JB, Koelle DM, Corey L, Flowers CR, Ahmed R
Treatment potential in APOL1-associated nephropathy.
1. Curr Opin Nephrol Hypertens - published September 1, 2022
2. Friedman DJ, Ma L, Freedman BI
Transient transfection and purification of SARS-CoV-2 spike protein from mammalian cells.
1. STAR Protoc - published September 1, 2022
2. Stalls V, Janowska K, Acharya P
Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein.
1. Cell Host Microbe - published September 1, 2022
2. Javanmardi K, Segall-Shapiro TH, Chou CW, Boutz DR, Olsen RJ, Xie X, Xia H, Shi PY, Johnson CD, Annapareddy A, Weaver S, Musser JM, Ellington AD, Finkelstein IJ, Gollihar JD
Label-free protocol to quantify protein affinity using isothermal titration calorimetry and bio-layer interferometry of a human eIF5-mimic protein.
1. STAR Protoc - published September 1, 2022
2. Singh CR, Jaiswal R, Escalante CR, Asano K
Compendium of proteins containing segments that exhibit zero-tolerance to amino acid variation in humans.
1. Protein Sci - published September 1, 2022
2. Sanders AL, Hermanson JN, Samuels DC, Plate L, Sanders CR
Of problems and opportunities-How to treat and how to not treat crystallographic fragment screening data.
1. Protein Sci - published September 1, 2022
2. Weiss MS, Wollenhaupt J, Correy GJ, Fraser JS, Heine A, Klebe G, Krojer T, Thunissen M, Pearce NM
Integrated multi-omic data reveal the potential molecular mechanisms of the nutrition and flavor in Liancheng white duck meat.
1. Front Genet - published September 1, 2022
2. Zhou H, Yang Y, Wang L, Ye S, Liu J, Gong P, Qian Y, Zeng H, Chen X
Crystallization and preliminary X-ray analysis of the C-type lectin domain of the spicule matrix protein SM50 from Strongylocentrotus purpuratus. Corrigendum.
1. Acta Crystallogr F Struct Biol Commun - published September 1, 2022
2. Ebenhoch R, Juneja P, Rao A, Cölfen H, Diederichs K, Welte W
Lisaftoclax (APG-2575) is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy.
1. Clin Cancer Res - published September 1, 2022
2. Deng J, Paulus A, Fang DD, Manna A, Wang G, Wang H, Zhu S, Chen J, Min P, Yin Y, Dutta N, Halder N, Ciccio G, Copland JA, Miller J, Han B, Bai L, Liu L, Wang M, McEachern D, Przybranowski S, Yang CY, Stuckey JA, Wu D, Li C, Ryan J, Letai A, Ailawadhi S, Yang D, Wang S, Chanan-Khan A, Zhai Y
Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade.
1. Elife - published September 1, 2022
2. Burnim AA, Spence MA, Xu D, Jackson CJ, Ando N
Cofactor-assisted dicing: insights from structural snapshots.
1. Cell Res - published September 1, 2022
2. Du J, Patel DJ
Affinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling.
1. Nat Chem Biol - published September 1, 2022
2. Gonzalez-Perez D, Das S, Antfolk D, Ahsan HS, Medina E, Dundes CE, Jokhai RT, Egan ED, Blacklow SC, Loh KM, Rodriguez PC, Luca VC
The hemolysin A secretion system is a multi-engine pump containing three ABC transporters.
1. Cell - published September 1, 2022
2. Zhao H, Lee J, Chen J
A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility.
1. Cell - published September 1, 2022
2. Sheu SH, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, Walpita D, Pasolli HA, Houser J, Sanchez-Martinez S, Brauchi SE, Banala S, Freeman M, Xu CS, Kirchhausen T, Hess HF, Lavis L, Li Y, Chaumont-Dubel S, Clapham DE
Inflammatory bowel disease and cardiovascular diseases.
1. Am J Med - published September 1, 2022
2. Chen B, Collen LV, Mowat C, Isaacs KL, Singh S, Kane SV, Loftus EV Jr, Farraye FA, Snapper S, Jneid H, Lavie CJ, Krittanawong C
Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests.
1. Cell - published September 1, 2022
2. Frank F, Keen MM, Rao A, Bassit L, Liu X, Bowers HB, Patel AB, Cato ML, Sullivan JA, Greenleaf M, Piantadosi A, Lam WA, Hudson WH, Ortlund EA
In silico prediction, characterization, docking studies and molecular dynamics simulation of human p97 in complex with p37 cofactor.
1. BMC Mol Cell Biol - published September 1, 2022
2. Mirzadeh A, Kobakhidze G, Vuillemot R, Jonic S, Rouiller I
SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.
1. PLoS Pathog - published September 1, 2022
2. Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Soveg FW, Gross JD, Krogan NJ, Jerome KR, Schilling B, Ott M, Verdin E
Structure and Function of the Nuclear Pore Complex.
1. Cold Spring Harb Perspect Biol - published September 1, 2022
2. Petrovic S, Mobbs GW, Bley CJ, Nie S, Patke A, Hoelz A
Transmembrane helices mediate the formation of a stable ternary complex of b₅R, cyt b₅, and SCD1.
1. Commun Biol - published September 1, 2022
2. Shen J, Wu G, Tsai AL, Zhou M
C3- and C3/C5-Epimerases Required for the Biosynthesis of the Capsular Polysaccharides from Campylobacter jejuni.
1. Biochemistry - published September 1, 2022
2. Ghosh MK, Xiang DF, Thoden JB, Holden HM, Raushel FM
Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1.
1. Nat Struct Mol Biol - published September 1, 2022
2. Prattes M, Grishkovskaya I, Hodirnau VV, Hetzmannseder C, Zisser G, Sailer C, Kargas V, Loibl M, Gerhalter M, Kofler L, Warren AJ, Stengel F, Haselbach D, Bergler H
Structural basis for topological regulation of Tn3 resolvase.
1. Nucleic Acids Res - published September 1, 2022
2. Montaño SP, Rowland SJ, Fuller JR, Burke ME, MacDonald AI, Boocock MR, Stark WM, Rice PA
A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy.
1. Cancer Cell - published September 1, 2022
2. Zhang Z, Rohweder PJ, Ongpipattanakul C, Basu K, Bohn MF, Dugan EJ, Steri V, Hann B, Shokat KM, Craik CS
Design of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody response.
1. Sci Adv - published September 1, 2022
2. Dickey TH, Tang WK, Butler B, Ouahes T, Orr-Gonzalez S, Salinas ND, Lambert LE, Tolia NH
Structural basis for APE1 processing DNA damage in the nucleosome.
1. Nat Commun - published September 1, 2022
2. Weaver TM, Hoitsma NM, Spencer JJ, Gakhar L, Schnicker NJ, Freudenthal BD
Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy.
1. Nat Commun - published September 1, 2022
2. Korir ML, Doster RS, Lu J, Guevara MA, Spicer SK, Moore RE, Francis JD, Rogers LM, Haley KP, Blackman A, Noble KN, Eastman AJ, Williams JA, Damo SM, Boyd KL, Townsend SD, Henrique Serezani C, Aronoff DM, Manning SD, Gaddy JA
Functional Comparison between Endogenous and Synthetic Notch Systems.
1. ACS Synth Biol - published September 1, 2022
2. Khamaisi B, Luca VC, Blacklow SC, Sprinzak D
A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability.
1. J Biol Chem - published September 1, 2022
2. Koochaki SHJ, Słabicki M, Lumpkin R, Zou C, Belizaire R, Fischer ES, Ebert BL
Development of Strategies for Community Engaged Research Dissemination by Basic Scientists: A Case Study.
1. Transl Res - published September 1, 2022
2. Stewart EC, Davis JS, Walters TS, Chen Z, Miller ST, Duke JM, Alexander LR, Russell R, Rowan N, Campbell L, Baxter I, Tolbert S, Erves JC
A structural platform for B cell receptor signaling.
1. Cell Res - published September 1, 2022
2. Xie W, Wucherpfennig K, Patel DJ
A general chemical principle for creating closure-stabilizing integrin inhibitors.
1. Cell - published September 1, 2022
2. Lin FY, Li J, Xie Y, Zhu J, Huong Nguyen TT, Zhang Y, Zhu J, Springer TA
The secreted protein Cowpox Virus 14 contributes to viral virulence and immune evasion by engaging Fc-gamma-receptors.
1. PLoS Pathog - published September 1, 2022
2. Iyer RF, Edwards DM, Kolb P, Raué HP, Nelson CA, Epperson ML, Slifka MK, Nolz JC, Hengel H, Fremont DH, Früh K
Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
1. J Med Chem - published September 1, 2022
2. Chana CK, Maisonneuve P, Posternak G, Grinberg NGA, Poirson J, Ona SM, Ceccarelli DF, Mader P, St-Cyr DJ, Pau V, Kurinov I, Tang X, Deng D, Cui W, Su W, Kuai L, Soll R, Tyers M, Röst HL, Batey RA, Taipale M, Gingras AC, Sicheri F
Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3.
1. Nat Chem - published September 1, 2022
2. Wang HY, Yang H, Holm M, Tom H, Oltion K, Al-Khdhairawi AAQ, Weber JF, Blanchard SC, Ruggero D, Taunton J
INOSITOL (1,3,4) TRIPHOSPHATE 5/6 KINASE1-Dependent Inositol Polyphosphates Regulate Auxin Responses in Arabidopsis.
1. Plant Physiol - published September 1, 2022
2. Laha NP, Giehl RFH, Riemer E, Qiu D, Pullagurla NJ, Schneider R, Dhir YW, Yadav R, Mihiret YE, Gaugler P, Gaugler V, Mao H, Zheng N, von Wirén N, Saiardi A, Bhattacharjee S, Jessen HJ, Laha D, Schaaf G
Structures of RNA ligase RtcB in complexes with divalent cations and GTP.
1. RNA - published September 1, 2022
2. Jacewicz A, Dantuluri S, Shuman S
A Comprehensive Evolutionary Study of Chloroplast RNA Editing in Gymnosperms: A Novel Type of G-to-A RNA Editing Is Common in Gymnosperms.
1. Int J Mol Sci - published September 1, 2022
2. Huang KY, Kan SL, Shen TT, Gong P, Feng YY, Du H, Zhao YP, Wan T, Wang XQ, Ran JH
Enzymatic and Molecular Characterization of Anti-Leishmania Molecules That Differently Target Leishmania and Mammalian eIF4A Proteins, LieIF4A and eIF4A_Mus.
1. Molecules - published September 1, 2022
2. Abdelkrim YZ, Harigua-Souiai E, Bassoumi-Jamoussi I, Barhoumi M, Banroques J, Essafi-Benkhadir K, Nilges M, Blondel A, Tanner NK, Guizani I
Building Protein Atomic Models from Cryo-EM Density Maps and Residue Co-Evolution.
1. Biomolecules - published September 1, 2022
2. Bouvier G, Bardiaux B, Pellarin R, Rapisarda C, Nilges M