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143 Member Publications for October 2022

Analysis of two cooperating antibodies unveils immune pressure imposed on HIV Env to elicit a V3-glycan supersite broadly neutralizing antibody lineage.
1. Front Immunol - published October 13, 2022
2. Finkelstein MT, Parker Miller E, Erdman MC, Fera D
Blocking LAIR1 signaling in immune cells inhibits tumor development.
1. Front Immunol - published October 10, 2022
2. Xie J, Gui X, Deng M, Chen H, Chen Y, Liu X, Ku Z, Tan L, Huang R, He Y, Zhang B, Lewis C, Chen K, Xu L, Xu J, Huang T, Liao XC, Zhang N, An Z, Zhang CC
Pairwise sequence similarity mapping with PaSiMap: Reclassification of immunoglobulin domains from titin as case study.
1. Comput Struct Biotechnol J - published October 10, 2022
2. Su K, Mayans O, Diederichs K, Fleming JR
Crystal Structures of Epstein-Barr Virus Bcl-2 Homolog BHRF1 Bound to Bid and Puma BH3 Motif Peptides.
1. Viruses - published October 9, 2022
2. Suraweera CD, Hinds MG, Kvansakul M
Microfluidic Enrichment and Computational Analysis of Rare Sequences from Mixed Genomic Samples for Metagenomic Mining.
1. CRISPR J - published October 7, 2022
2. Cui N, Faure G, Singh A, Macrae R, Zhang F
Comparative genomic and biochemical analyses identify a collagen galactosylhydroxylysyl glucosyltransferase from Acanthamoeba polyphaga mimivirus.
1. Sci Rep - published October 7, 2022
2. Wu W, Kim JS, Bailey AO, Russell WK, Richards SJ, Chen T, Chen T, Chen Z, Liang B, Yamauchi M, Guo H
A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses.
1. Commun Biol - published October 7, 2022
2. Gross SM, Dane MA, Smith RL, Devlin KL, McLean IC, Derrick DS, Mills CE, Subramanian K, London AB, Torre D, Evangelista JE, Clarke DJB, Xie Z, Erdem C, Lyons N, Natoli T, Pessa S, Lu X, Mullahoo J, Li J, Adam M, Wassie B, Liu M, Kilburn DF, Liby TA, Bucher E, Sanchez-Aguila C, Daily K, Omberg L, Wang Y, Jacobson C, Yapp C, Chung M, Vidovic D, Lu Y, Schurer S, Lee A, Pillai A, Subramanian A, Papanastasiou M, Fraenkel E, Feiler HS, Mills GB, Jaffe JD, Ma'ayan A, Birtwistle MR, Sorger PK, Korkola JE, Gray JW, Heiser LM
The Vaccinia Virus DNA Helicase Structure from Combined Single-Particle Cryo-Electron Microscopy and AlphaFold2 Prediction.
1. Viruses - published October 7, 2022
2. Hutin S, Ling WL, Tarbouriech N, Schoehn G, Grimm C, Fischer U, Burmeister WP
Bimetallic Alloys b-As_xP_1-x at High Concentration Differences: Ideal for Photonic Devices.
1. J Phys Chem Lett - published October 6, 2022
2. Liu F, Yu Q, Xue J, Shu B, Zheng C, Deng H, Zhang X, Gong P, Chen M, Lin H, Wang J, Zhu S, Wu J
Loss-of-function variants in MYCBP2 cause neurobehavioural phenotypes and corpus callosum defects.
1. Brain - published October 6, 2022
2. AlAbdi L, Desbois M, Rusnac DV, Sulaiman RA, Rosenfeld JA, Lalani S, Murdock DR, Burrage LC, Undiagnosed Diseases Network., Billie Au PY, Towner S, Wilson WG, Wong L, Brunet T, Strobl-Wildemann G, Burton JE, Hoganson G, McWalter K, Begtrup A, Zarate YA, Christensen EL, Opperman KJ, Giles AC, Helaby R, Kania A, Zheng N, Grill B, Alkuraya FS
The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation.
1. Nat Commun - published October 6, 2022
2. Duszczyk MM, Wischnewski H, Kazeeva T, Arora R, Loughlin FE, von Schroetter C, Pradère U, Hall J, Ciaudo C, Allain FH
Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion.
1. Nat Commun - published October 6, 2022
2. Patel PN, Dickey TH, Hopp CS, Diouf A, Tang WK, Long CA, Miura K, Crompton PD, Tolia NH
Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers.
1. Commun Biol - published October 6, 2022
2. Hakkaart C, Pearson JF, Marquart L, Dennis J, Wiggins GAR, Barnes DR, Robinson BA, Mace PD, Aittomäki K, Andrulis IL, Arun BK, Azzollini J, Balmaña J, Barkardottir RB, Belhadj S, Berger L, Blok MJ, Boonen SE, Borde J, Bradbury AR, Brunet J, Buys SS, Caligo MA, Campbell I, Chung WK, Claes KBM, GEMO Study Collaborators., EMBRACE Collaborators., Collonge-Rame MA, Cook J, Cosgrove C, Couch FJ, Daly MB, Dandiker S, Davidson R, de la Hoya M, de Putter R, Delnatte C, Dhawan M, Diez O, Ding YC, Domchek SM, Donaldson A, Eason J, Easton DF, Ehrencrona H, Engel C, Evans DG, Faust U, Feliubadaló L, Fostira F, Friedman E, Frone M, Frost D, Garber J, Gayther SA, Gehrig A, Gesta P, Godwin AK, Goldgar DE, Greene MH, Hahnen E, Hake CR, Hamann U, Hansen TVO, Hauke J, Hentschel J, Herold N, Honisch E, Hulick PJ, Imyanitov EN, SWE-BRCA Investigators., kConFab Investigators., HEBON Investigators., Isaacs C, Izatt L, Izquierdo A, Jakubowska A, James PA, Janavicius R, John EM, Joseph V, Karlan BY, Kemp Z, Kirk J, Konstantopoulou I, Koudijs M, Kwong A, Laitman Y, Lalloo F, Lasset C, Lautrup C, Lazaro C, Legrand C, Leslie G, Lesueur F, Mai PL, Manoukian S, Mari V, Martens JWM, McGuffog L, Mebirouk N, Meindl A, Miller A, Montagna M, Moserle L, Mouret-Fourme E, Musgrave H, Nambot S, Nathanson KL, Neuhausen SL, Nevanlinna H, Yie JNY, Nguyen-Dumont T, Nikitina-Zake L, Offit K, Olah E, Olopade OI, Osorio A, Ott CE, Park SK, Parsons MT, Pedersen IS, Peixoto A, Perez-Segura P, Peterlongo P, Pocza T, Radice P, Ramser J, Rantala J, Rodriguez GC, Rønlund K, Rosenberg EH, Rossing M, Schmutzler RK, Shah PD, Sharif S, Sharma P, Side LE, Simard J, Singer CF, Snape K, Steinemann D, Stoppa-Lyonnet D, Sutter C, Tan YY, Teixeira MR, Teo SH, Thomassen M, Thull DL, Tischkowitz M, Toland AE, Trainer AH, Tripathi V, Tung N, van Engelen K, van Rensburg EJ, Vega A, Viel A, Walker L, Weitzel JN, Wevers MR, Chenevix-Trench G, Spurdle AB, Antoniou AC, Walker LC
Protocol to quantify enzymatic effects on vitreous liquefaction in porcine eyes using a transwell-plate system.
1. STAR Protoc - published October 6, 2022
2. Wolf J, Sabage LE, Sun YJ, Mahajan VB
Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation.
1. Cell Chem Biol - published October 6, 2022
2. You I, Donovan KA, Krupnick NM, Boghossian AS, Rees MG, Ronan MM, Roth JA, Fischer ES, Wang ES, Gray NS
Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis.
1. Cell Metab - published October 6, 2022
2. Zhang Z, Jiang Y, Su L, Ludwig S, Zhang X, Tang M, Li X, Anderton P, Zhan X, Choi M, Russell J, Bu CH, Lyon S, Xu D, Hildebrand S, Scott L, Quan J, Simpson R, Sun Q, Qin B, Collie T, Tadesse M, Moresco EMY, Beutler B
The brain-specific splice variant of the CDC42 GTPase works together with the kinase ACK to down-regulate the EGF receptor in promoting neurogenesis.
1. J Biol Chem - published October 5, 2022
2. Endo M, Cerione RA
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.
1. Proc Natl Acad Sci U S A - published October 4, 2022
2. Yang K, Wang C, Kreutzberger AJB, Ojha R, Kuivanen S, Couoh-Cardel S, Muratcioglu S, Eisen TJ, White KI, Held RG, Subramanian S, Marcus K, Pfuetzner RA, Esquivies L, Doyle CA, Kuriyan J, Vapalahti O, Balistreri G, Kirchhausen T, Brunger AT
Characterization of a Radical SAM Oxygenase for the Ether Crosslinking in Darobactin Biosynthesis.
1. J Am Chem Soc - published October 4, 2022
2. Nguyen H, Made Kresna ID, Böhringer N, Ruel J, Mora E, Kramer JC, Lewis K, Nicolet Y, Schäberle TF, Yokoyama K
Rift Valley Fever Virus Infects the Posterior Segment of the Eye and Induces Inflammation in a Rat Model of Ocular Disease.
1. J Virol - published October 4, 2022
2. Schwarz MM, Connors KA, Davoli KA, McMillen CM, Albe JR, Hoehl RM, Demers MJ, Ganaie SS, Price DA, Leung DW, Amarasinghe GK, McElroy AK, Reed DS, Hartman AL
MCL-1 is a master regulator of cancer dependency on fatty acid oxidation.
1. Cell Rep - published October 4, 2022
2. Prew MS, Adhikary U, Choi DW, Portero EP, Paulo JA, Gowda P, Budhraja A, Opferman JT, Gygi SP, Danial NN, Walensky LD
Protein Data Bank: A Comprehensive Review of 3D Structure Holdings and Worldwide Utilization by Researchers, Educators, and Students.
1. Biomolecules - published October 4, 2022
2. Burley SK, Berman HM, Duarte JM, Feng Z, Flatt JW, Hudson BP, Lowe R, Peisach E, Piehl DW, Rose Y, Sali A, Sekharan M, Shao C, Vallat B, Voigt M, Westbrook JD, Young JY, Zardecki C
Lipid Expansion Microscopy.
1. J Am Chem Soc - published October 3, 2022
2. White BM, Kumar P, Conwell AN, Wu K, Baskin JM
Toward more potent imidazopyridine inhibitors of Candida albicans Bdf1: Modeling the role of structural waters in selective ligand binding.
1. J Comput Chem - published October 3, 2022
2. Zhou Y, Overhulse JM, Dupper NJ, Guo Y, Kashemirov BA, Wei K, Govin J, Petosa C, McKenna CE
The synergistic compatibility mechanisms of fuzi against chronic heart failure in animals: A systematic review and meta-analysis.
1. Front Pharmacol - published October 3, 2022
2. Liu X, Xie X, Luo M, Zhao Y, Li M, Peng F, Peng C
Hiding in plain sight: three chemically distinct α-helix types - ERRATUM.
1. Q Rev Biophys - published October 3, 2022
2. Zhang S, Egli M
A language model beats alphafold2 on orphans.
1. Nat Biotechnol - published October 3, 2022
2. Michaud JM, Madani A, Fraser JS
IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern.
1. Nat Commun - published October 3, 2022
2. Chang MR, Tomasovic L, Kuzmina NA, Ronk AJ, Byrne PO, Johnson R, Storm N, Olmedillas E, Hou YJ, Schäfer A, Leist SR, Tse LV, Ke H, Coherd C, Nguyen K, Kamkaew M, Honko A, Zhu Q, Alter G, Saphire EO, McLellan JS, Griffiths A, Baric RS, Bukreyev A, Marasco WA
Single-sequence protein structure prediction using a language model and deep learning.
1. Nat Biotechnol - published October 3, 2022
2. Chowdhury R, Bouatta N, Biswas S, Floristean C, Kharkare A, Roye K, Rochereau C, Ahdritz G, Zhang J, Church GM, Sorger PK, AlQuraishi M
Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation.
1. J Biol Chem - published October 3, 2022
2. Carlson CR, Adly AN, Bi M, Howard CJ, Frost A, Cheng Y, Morgan DO
A cryptic transcription factor regulates Caulobacter adhesin development.
1. PLoS Genet - published October 3, 2022
2. McLaughlin M, Hershey DM, Reyes Ruiz LM, Fiebig A, Crosson S
Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons.
1. mBio - published October 3, 2022
2. Kong W, Montano M, Corley MJ, Helmy E, Kobayashi H, Kinisu M, Suryawanshi R, Luo X, Royer LA, Roan NR, Ott M, Ndhlovu LC, Greene WC
Long-Lasting Protection Induced by a Polyanhydride Nanovaccine against Respiratory Syncytial Virus in an Outbred Mouse Model.
1. J Virol - published October 3, 2022
2. Stephens LM, Ross KA, McLellan JS, Narasimhan B, Varga SM
Infant Antibody Repertoires during the First Two Years of Influenza Vaccination.
1. mBio - published October 3, 2022
2. Kuraoka M, Curtis NC, Watanabe A, Tanno H, Shin S, Ye K, Macdonald E, Lavidor O, Kong S, Von Holle T, Windsor I, Ippolito GC, Georgiou G, Walter EB, Kelsoe G, Harrison SC, Moody MA, Bajic G, Lee J
Identification of potential candidate genes and regulatory pathways related to reproductive capacity in hypothalamus and pituitarium of male ducks (Anas platyrhynchos) by differential transcriptome analysis.
1. J Anim Sci - published October 3, 2022
2. Zhang Z, Yang Y, Huang L, Chen L, Zhang G, Gong P, Ye S, Feng Y
In through the Out Door: A Functional Virulence Factor Secretion System Is Necessary for Phage Infection in Ralstonia solanacearum.
1. mBio - published October 3, 2022
2. Xavier ADS, de Melo AG, Hendrich CG, Tremblay DM, Rousseau GM, Plante PL, Forest KT, Alfenas-Zerbini P, Allen C, Moineau S
A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology.
1. Elife - published October 3, 2022
2. Campbell BFN, Dittmann A, Dreier B, Plückthun A, Tyagarajan SK
Nebulized mRNA-Encoded Antibodies Protect Hamsters from SARS-CoV-2 Infection.
1. Adv Sci (Weinh) - published October 3, 2022
2. Vanover D, Zurla C, Peck HE, Orr-Burks N, Joo JY, Murray J, Holladay N, Hobbs RA, Jung Y, Chaves LCS, Rotolo L, Lifland AW, Olivier AK, Li D, Saunders KO, Sempowski GD, Crowe JE Jr, Haynes BF, Lafontaine ER, Hogan RJ, Santangelo PJ
Prediction of early-stage melanoma recurrence using clinical and histopathologic features.
1. NPJ Precis Oncol - published October 3, 2022
2. Wan G, Nguyen N, Liu F, DeSimone MS, Leung BW, Rajeh A, Collier MR, Choi MS, Amadife M, Tang K, Zhang S, Phillipps JS, Jairath R, Alexander NA, Hua Y, Jiao M, Chen W, Ho D, Duey S, Németh IB, Marko-Varga G, Valdés JG, Liu D, Boland GM, Gusev A, Sorger PK, Yu KH, Semenov YR
Estimated Versus Measured Glomerular Filtration Rate in Men at Risk for Mesoamerican Nephropathy.
1. Am J Kidney Dis - published October 3, 2022
2. Raines NH, Inker LA, Seegmiller JC, Brooks DR, Gonzalez-Quiroz M, Friedman DJ
Exploring ABOBEC3A and APOBEC3B substrate specificity and their role in HPV positive head and neck cancer.
1. iScience - published October 2, 2022
2. Papini C, Wang Z, Kudalkar SN, Schrank TP, Tang S, Sasaki T, Wu C, Tejada B, Ziegler SJ, Xiong Y, Issaeva N, Yarbrough WG, Anderson KS
Lessons from the pandemic: Responding to emerging zoonotic viral diseases-a Keystone Symposia report.
1. Ann N Y Acad Sci - published October 2, 2022
2. Cable J, Fauci A, Dowling WE, Günther S, Bente DA, Yadav PD, Madoff LC, Wang LF, Arora RK, Van Kerkhove M, Chu MC, Jaenisch T, Epstein JH, Frost SDW, Bausch DG, Hensley LE, Bergeron É, Sitaras I, Gunn MD, Geisbert TW, Muñoz-Fontela C, Krammer F, de Wit E, Nordenfelt P, Saphire EO, Gilbert SC, Corbett KS, Branco LM, Baize S, van Doremalen N, Krieger MA, Clemens SAC, Hesselink R, Hartman D
A unified approach to sequential and non-sequential structure alignment of proteins, RNAs, and DNAs.
1. iScience - published October 2, 2022
2. Zhang C, Pyle AM
Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics.
1. Proc Natl Acad Sci U S A - published October 2, 2022
2. Nye TM, Tükenmez H, Singh P, Flores-Mireles AL, Obernuefemann CLP, Pinkner JS, Sarkar S, Bonde M, Lindgren AEG, Dodson KW, Johansson J, Almqvist F, Caparon MG, Hultgren SJ
Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
1. J Med Chem - published October 2, 2022
2. Narayanan D, Tran KT, Pallesen JS, Solbak SMØ, Qin Y, Mukminova E, Luchini M, Vasilyeva KO, González Chichón D, Goutsiou G, Poulsen C, Haapanen N, Popowicz GM, Sattler M, Olagnier D, Gajhede M, Bach A
Molecular structures reveal synergistic rescue of Δ508 CFTR by Trikafta modulators.
1. Science - published October 2, 2022
2. Fiedorczuk K, Chen J
Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes.
1. Elife - published October 2, 2022
2. Juette MF, Carelli JD, Rundlet EJ, Brown A, Shao S, Ferguson A, Wasserman MR, Holm M, Taunton J, Blanchard SC
Structure and flexibility of the yeast NuA4 histone acetyltransferase complex.
1. Elife - published October 2, 2022
2. Zukin SA, Marunde MR, Popova IK, Soczek KM, Nogales E, Patel AB
RfaH Counter-Silences Inhibition of Transcript Elongation by H-NS-StpA Nucleoprotein Filaments in Pathogenic Escherichia coli.
1. mBio - published October 2, 2022
2. Hustmyer CM, Wolfe MB, Welch RA, Landick R
Venetoclax and idasanutlin in relapsed/refractory AML: a non-randomized, open-label phase 1b trial.
1. Blood - published October 2, 2022
2. Daver NG, Dail M, Garcia JS, Jonas BA, Yee KWL, Kelly KR, Vey N, Assouline S, Roboz GJ, Paolini S, Pollyea DA, Tafuri A, Brandwein JM, Pigneux A, Powell BL, Fenaux P, Olin RL, Visani G, Martinelli G, Onishi M, Wang J, Huang W, Green C, Ott MG, Hong WJ, Konopleva MY, Andreeff M
The beauty of simplicity in membrane biology.
1. Nat Cell Biol - published October 2, 2022
2. Stachowiak JC, Kirchhausen T
Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069.
1. J Med Chem - published October 2, 2022
2. Orsi DL, Pook E, Bräuer N, Friberg A, Lienau P, Lemke CT, Stellfeld T, Brüggemeier U, Pütter V, Meyer H, Baco M, Tang S, Cherniack AD, Westlake L, Bender SA, Kocak M, Strathdee CA, Meyerson M, Eis K, Goldstein JT
Hierarchical time-series analysis of dynamic bioprocess systems.
1. Biotechnol J - published October 2, 2022
2. Alinaghi M, Surowiec I, Scholze S, McCready C, Zehe C, Johansson E, Trygg J, Cloarec O
Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co-Condensation of Wnt Signalodroplets.
1. Small - published October 2, 2022
2. Philippi M, Richter CP, Kappen M, Watrinet I, Miao Y, Runge M, Jorde L, Korneev S, Holtmannspötter M, Kurre R, Holthuis JCM, Garcia KC, Plückthun A, Steinhart M, Piehler J, You C
Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA.
1. J Med Chem - published October 2, 2022
2. Fathalla RK, Fröhner W, Bader CD, Fischer PD, Dahlem C, Chatterjee D, Mathea S, Kiemer AK, Arthanari H, Müller R, Abdel-Halim M, Ducho C, Engel M
Leveraging patient derived models of FGFR2 fusion positive intrahepatic cholangiocarcinoma to identify synergistic therapies.
1. NPJ Precis Oncol - published October 2, 2022
2. Lidsky ME, Wang Z, Lu M, Liu A, Hsu SD, McCall SJ, Sheng Z, Granek JA, Owzar K, Anderson KS, Wood KC
Structure-Based Discovery of a Novel Class of Small-Molecule Pure Antagonists of Integrin αVβ3.
1. J Chem Inf Model - published October 2, 2022
2. Sen S, Spasic A, Sinha A, Wang J, Bush M, Li J, Nešić D, Zhou Y, Angiulli G, Morgan P, Salas-Estrada L, Takagi J, Walz T, Coller BS, Filizola M
SCF^FBXW7 regulates G2-M progression through control of CCNL1 ubiquitination.
1. EMBO Rep - published October 2, 2022
2. O'Brien S, Kelso S, Steinhart Z, Orlicky S, Mis M, Kim Y, Lin S, Sicheri F, Angers S
A first-principles study of the ultra-high spin rectification effect based on nitride MXenes (Sc₂NO₂, Ti₂NO₂).
1. Phys Chem Chem Phys - published October 2, 2022
2. Gong P, Zhang X, Liu F, Zhu S
Editorial overview: Understanding membrane and membrane proteins: Where do we go now?
1. Curr Opin Struct Biol - published October 2, 2022
2. Banerjee A, Palacín M
Imaging and Editing the Phospholipidome.
1. Acc Chem Res - published October 2, 2022
2. Chiu DC, Baskin JM
Ribosome-mediated biosynthesis of pyridazinone oligomers in vitro.
1. Nat Commun - published October 2, 2022
2. Lee J, Coronado JN, Cho N, Lim J, Hosford BM, Seo S, Kim DS, Kofman C, Moore JS, Ellington AD, Anslyn EV, Jewett MC
Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
1. Neuron - published October 2, 2022
2. Zhao C, MacKinnon R
A type III-E CRISPR Craspase exhibiting RNase and protease activities.
1. Cell Res - published October 2, 2022
2. Yang H, Patel DJ
An RSV live-attenuated vaccine candidate lacking G protein mucin domains is attenuated, immunogenic, and effective in preventing RSV in BALB/c mice.
1. J Infect Dis - published October 2, 2022
2. Roe MK, Perez MA, Hsiao HM, Lapp SA, Sun HY, Jadhao S, Young AR, Batista YS, Reed RC, Taz A, Piantadosi A, Chen X, Liang B, Koval M, Snider TA, Moore ML, Anderson EJ, Anderson LJ, Stobart CC, Rostad CA
Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein.
1. Cell Rep - published October 2, 2022
2. Park JS, Choi J, Cao L, Mohanty J, Suzuki Y, Park A, Baker D, Schlessinger J, Lee S
Engineering of HIV-1 neutralizing antibody CAP256V2LS for manufacturability and improved half life.
1. Sci Rep - published October 2, 2022
2. Zhang B, Gollapudi D, Gorman J, O'Dell S, Damron LF, McKee K, Asokan M, Yang ES, Pegu A, Lin BC, Chao CW, Chen X, Gama L, Ivleva VB, Law WH, Liu C, Louder MK, Schmidt SD, Shen CH, Shi W, Stein JA, Seaman MS, McDermott AB, Carlton K, Mascola JR, Kwong PD, Lei QP, Doria-Rose NA
Novel cryo-tomography workflow reveals nanometer-scale responses of epithelial cells to matrix stiffness and dimensionality.
1. Mol Biol Cell - published October 2, 2022
2. Gaietta G, Kai F, Swift MF, Weaver VM, Volkmann N, Hanein D
Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose).
1. Cell Rep - published October 2, 2022
2. Kuttiyatveetil JRA, Soufari H, Dasovich M, Uribe IR, Mirhasan M, Cheng SJ, Leung AKL, Pascal JM
Polerovirus N-terminal readthrough domain structures reveal molecular strategies for mitigating virus transmission by aphids.
1. Nat Commun - published October 2, 2022
2. Schiltz CJ, Wilson JR, Hosford CJ, Adams MC, Preising SE, DeBlasio SL, MacLeod HJ, Van Eck J, Heck ML, Chappie JS
Design, Synthesis, and Evaluation of a Cross-Linked Oligonucleotide as the First Nanomolar Inhibitor of APOBEC3A.
1. Biochemistry - published October 2, 2022
2. Kurup HM, Kvach MV, Harjes S, Barzak FM, Jameson GB, Harjes E, Filichev VV
Covalent disruptor of YAP-TEAD association suppresses defective hippo signaling.
1. Elife - published October 2, 2022
2. Fan M, Lu W, Che J, Kwiatkowski NP, Gao Y, Seo HS, Ficarro SB, Gokhale PC, Liu Y, Geffken EA, Lakhani J, Song K, Kuljanin M, Ji W, Jiang J, He Z, Tse J, Boghossian AS, Rees MG, Ronan MM, Roth JA, Mancias JD, Marto JA, Dhe-Paganon S, Zhang T, Gray NS
Small-molecule inhibition of the archetypal UbiB protein COQ8.
1. Nat Chem Biol - published October 2, 2022
2. Murray NH, Asquith CRM, Fang Z, East MP, Ptak N, Smith RW, Vasta JD, Zimprich CA, Corona CR, Robers MB, Johnson GL, Bingman CA, Pagliarini DJ
Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains.
1. Nat Biotechnol - published October 2, 2022
2. Speltz TE, Qiao Z, Swenson CS, Shangguan X, Coukos JS, Lee CW, Thomas DM, Santana J, Fanning SW, Greene GL, Moellering RE
Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack.
1. Nat Commun - published October 2, 2022
2. Yang S, Hiotis G, Wang Y, Chen J, Wang JH, Kim M, Reinherz EL, Walz T
Structural basis for Cas9 off-target activity.
1. Cell - published October 2, 2022
2. Pacesa M, Lin CH, Cléry A, Saha A, Arantes PR, Bargsten K, Irby MJ, Allain FH, Palermo G, Cameron P, Donohoue PD, Jinek M
Surface Passivation with a Perfluoroalkane Brush Improves the Precision of Single-Molecule Measurements.
1. ACS Appl Mater Interfaces - published October 2, 2022
2. Bueno-Alejo CJ, Santana Vega M, Chaplin AK, Farrow C, Axer A, Burley GA, Dominguez C, Kara H, Paschalis V, Tubasum S, Eperon IC, Clark AW, Hudson AJ
Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition.
1. Immunity - published October 2, 2022
2. Chen WH, Kim J, Bu W, Board NL, Tsybovsky Y, Wang Y, Hostal A, Andrews SF, Gillespie RA, Choe M, Stephens T, Yang ES, Pegu A, Peterson CE, Fisher BE, Mascola JR, Pittaluga S, McDermott AB, Kanekiyo M, Joyce MG, Cohen JI
BAF complex maintains glioma stem cells in pediatric H3K27M-glioma.
1. Cancer Discov - published October 2, 2022
2. Panditharatna E, G Marques J, Wang T, Trissal MC, Liu I, Jiang L, Beck A, Groves A, Dharia NV, Li D, Hoffman SE, Kugener G, Shaw ML, Mire HM, Hack OA, Dempster JM, Lareau C, Dai L, Sigua LH, Quezada MA, Stanton AJ, Wyatt M, Kalani Z, Goodale A, Vazquez F, Piccioni F, Doench JG, Root DE, Anastas JN, Jones KL, Saur Conway A, Stopka S, Regan MS, Liang Y, Seo HS, Song K, Bashyal P, Jerome WP, Mathewson ND, Dhe-Paganon S, Suva ML, Carcaboso AM, Lavarino C, Mora J, Nguyen QD, Ligon KL, Shi Y, Agnihotri S, Agar NYR, Stegmaier K, Stiles CD, Monje M, Golub TR, Qi J, Filbin MG
Analysis of tripartite Synaptotagmin-1-SNARE-complexin-1 complexes in solution.
1. FEBS Open Bio - published October 2, 2022
2. Jaczynska K, Esquivies L, Pfuetzner RA, Alten B, Brewer KD, Zhou Q, Kavalali ET, Brunger AT, Rizo J
Why are some people more attractive to mosquitoes than others?
1. Cell - published October 2, 2022
2. Zhao J, Del Mármol J
Structure and functionality of a multimeric human COQ7:COQ9 complex.
1. Mol Cell - published October 2, 2022
2. Manicki M, Aydin H, Abriata LA, Overmyer KA, Guerra RM, Coon JJ, Dal Peraro M, Frost A, Pagliarini DJ
Analysis of insertions and extensions in the functional evolution of the ribonucleotide reductase family.
1. Protein Sci - published October 2, 2022
2. Burnim AA, Xu D, Spence MA, Jackson C, Ando N
A novel connection between Trypanosoma brucei mitochondrial proteins TbTim17 and TbTRAP1 is discovered using Biotinylation Identification (BioID).
1. J Biol Chem - published October 2, 2022
2. Soto-Gonzalez F, Tripathi A, Cooley A, Paromov V, Rana T, Chaudhuri M
Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8(+) T cell immunity.
1. Nat Commun - published October 2, 2022
2. Rosás-Umbert M, Gunst JD, Pahus MH, Olesen R, Schleimann M, Denton PW, Ramos V, Ward A, Kinloch NN, Copertino DC, Escribà T, Llano A, Brumme ZL, Brad Jones R, Mothe B, Brander C, Fox J, Nussenzweig MC, Fidler S, Caskey M, Tolstrup M, Søgaard OS
Rieske Oxygenase Catalyzed C-H Bond Functionalization Reactions in Chlorophyll b Biosynthesis.
1. ACS Cent Sci - published October 2, 2022
2. Liu J, Knapp M, Jo M, Dill Z, Bridwell-Rabb J
Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964.
1. Structure - published October 2, 2022
2. Kelso S, O'Brien S, Kurinov I, Angers S, Sicheri F
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein.
1. DNA Repair (Amst) - published October 2, 2022
2. Bhat DS, Spies MA, Spies M
Smart data collection for CryoEM.
1. J Struct Biol - published October 2, 2022
2. Bepler T, Borst AJ, Bouvette J, Cannone G, Chen S, Cheng A, Cheng A, Fan Q, Grollios F, Gupta H, Gupta M, Humphreys T, Kim PT, Kuang H, Li Y, Noble AJ, Punjani A, Rice WJ, Oscar S Sorzano C, Stagg SM, Strauss J, Yu L, Carragher B, Potter CS
Iminologous epoxide ring-closure.
1. Chem Sci - published October 2, 2022
2. Tien CH, Lough AJ, Yudin AK
High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma.
1. Pharmaceuticals (Basel) - published October 2, 2022
2. Garcha HK, Nawar N, Sorger H, Erdogan F, Aung MMK, Sedighi A, Manaswiyoungkul P, Seo HS, Schönefeldt S, Pölöske D, Dhe-Paganon S, Neubauer HA, Mustjoki SM, Herling M, de Araujo ED, Moriggl R, Gunning PT
Structure and Catalytic Mechanism of Radical SAM Methylases.
1. Life (Basel) - published October 2, 2022
2. Nguyen TQ, Nicolet Y
Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes.
1. Immunity - published October 2, 2022
2. Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Binding stoichiometry and structural model of the HIV-1 Rev/importin β complex.
1. Life Sci Alliance - published October 1, 2022
2. Spittler D, Indorato RL, Boeri Erba E, Delaforge E, Signor L, Harris SJ, Garcia-Saez I, Palencia A, Gabel F, Blackledge M, Noirclerc-Savoye M, Petosa C
Personalized structural biology reveals the molecular mechanisms underlying heterogeneous epileptic phenotypes caused by de novo KCNC2 variants.
1. HGG Adv - published October 1, 2022
2. Mukherjee S, Cassini TA, Hu N, Yang T, Li B, Shen W, Moth CW, Rinker DC, Sheehan JH, Cogan JD, Undiagnosed Diseases Network., Newman JH, Hamid R, Macdonald RL, Roden DM, Meiler J, Kuenze G, Phillips JA, Capra JA
AML-131 ERG: From a Fortuitous Discovery to Potential Treatment for AML.
1. Clin Lymphoma Myeloma Leuk - published October 1, 2022
2. Kugler E, Madiwale S, Yong D, Birger Y, Thoms JA, Sykes DB, Yassin M, Aqaqe N, Rein A, Fishman H, Geron I, Chen CW, Raught B, Liu Q, Milyavsky M, Pimanda J, Privé GG, Izraeli S
CLL-120 Pirtobrutinib, A Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Previously Treated CLL/SLL: Updated Results from the Phase 1/2 BRUIN Study.
1. Clin Lymphoma Myeloma Leuk - published October 1, 2022
2. Coombs CC, Pagel JM, Shah NN, Lamanna N, Munir T, Lech-Maranda E, Eyre TA, Woyach JA, Wierda WG, Cheah CY, Cohen JB, Roeker LE, Patel MR, Fakhri B, Barve MA, Tam CS, Lewis D, Gerson JN, Alencar A, Ujjani C, Flinn I, Sundaram S, Ma S, Jagadeesh D, Rhodes J, Taylor J, Abdel-Wahab O, Ghia P, Schuster SJ, Wang D, Nair B, Zhu E, Tsai DE, Davids MS, Brown JR, Jurczak W, Mato AR
The green pigment of life.
1. Nat Chem - published October 1, 2022
2. Knapp M, Bridwell-Rabb J
Saturation mutagenesis of a predicted ancestral Syk-family kinase.
1. Protein Sci - published October 1, 2022
2. Hobbs HT, Shah NH, Shoemaker SR, Amacher JF, Marqusee S, Kuriyan J
Expanding the eukaryotic genetic code with a biosynthesized 21st amino acid.
1. Protein Sci - published October 1, 2022
2. Wu KL, Moore JA, Miller MD, Chen Y, Lee C, Xu W, Peng Z, Duan Q, Phillips GN Jr, Uribe RA, Xiao H
SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.
1. Proc Natl Acad Sci U S A - published October 1, 2022
2. Gui M, Croft JT, Zabeo D, Acharya V, Kollman JM, Burgoyne T, Höög JL, Brown A
Antigen-specific depletion of CD4⁺ T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity.
1. Sci Immunol - published October 1, 2022
2. Yi J, Miller AT, Archambault AS, Jones AJ, Bradstreet TR, Bandla S, Hsu YS, Edelson BT, Zhou YW, Fremont DH, Egawa T, Singh N, Wu GF, Hsieh CS
Probing Molecular Interactions of Antibody Drugs, Silicone Oil, and Surfactant at Buried Interfaces In Situ.
1. Anal Chem - published October 1, 2022
2. Lu T, Fu L, Qiu Y, Zhang J, Chen Z
Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
1. J Med Chem - published October 1, 2022
2. Wang Y, Xu F, Nichols CB, Shi Y, Hellinga HW, Alspaugh JA, Distefano MD, Beese LS
Microtubule-severing enzymes.
1. Curr Biol - published October 1, 2022
2. Sarbanes SL, Zehr EA, Roll-Mecak A
SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers.
1. Biochemistry - published October 1, 2022
2. Somberg NH, Wu WW, Medeiros-Silva J, Dregni AJ, Jo H, DeGrado WF, Hong M
Sequential action of a tRNA base editor in conversion of cytidine to pseudouridine.
1. Nat Commun - published October 1, 2022
2. Kimura S, Srisuknimit V, McCarty KL, Dedon PC, Kranzusch PJ, Waldor MK
Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance.
1. Cancer Discov - published October 1, 2022
2. Lyu J, Liu Y, Gong L, Chen M, Madanat YF, Zhang Y, Cai F, Gu Z, Cao H, Kaphle P, Kim YJ, Kalkan FN, Stephens H, Dickerson KE, Ni M, Chen W, Patel P, Mims AS, Borate U, Burd A, Cai SF, Yin CC, You MJ, Chung SS, Collins RH, DeBerardinis RJ, Liu X, Xu J
The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells.
1. Sci Adv - published October 1, 2022
2. Galazzo L, Meier G, Januliene D, Parey K, De Vecchis D, Striednig B, Hilbi H, Schäfer LV, Kuprov I, Moeller A, Bordignon E, Seeger MA
Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA.
1. Nature - published October 1, 2022
2. Hirano S, Kappel K, Altae-Tran H, Faure G, Wilkinson ME, Kannan S, Demircioglu FE, Yan R, Shiozaki M, Yu Z, Makarova KS, Koonin EV, Macrae RK, Zhang F
Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors.
1. Nat Commun - published October 1, 2022
2. Chou DB, Furlong BA, Posey RR, Kyprianou C, O'Sullivan LR, David R, Randle SJ, Polanska UM, Travers J, Urosevic J, Hutchinson JN, Che J, Howley AM, Hasserjian RP, Prantil-Baun R, Ingber DE
Chorioretinal atrophy following voretigene neparvovec despite the presence of fundus autofluorescence.
1. Mol Genet Genomic Med - published October 1, 2022
2. Kolesnikova M, Lima de Carvalho JR Jr, Parmann R, Kim AH, Mahajan VB, Tsang SH, Sparrow JR
Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition.
1. Proc Natl Acad Sci U S A - published October 1, 2022
2. Frias ES, Hoseini MS, Krukowski K, Paladini MS, Grue K, Ureta G, Rienecker KDA, Walter P, Stryker MP, Rosi S
Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function.
1. Proc Natl Acad Sci U S A - published October 1, 2022
2. Hawley KM, Eclov RJ, Schnorenberg MR, Tian Y, Shah RN, Thomas-Toth AT, Fefferman M, Bird GH, Walensky LD, Tirrell MV, LaBelle JL
Structural principles of B-cell antigen receptor assembly.
1. Nature - published October 1, 2022
2. Dong Y, Pi X, Bartels-Burgahn F, Saltukoglu D, Liang Z, Yang J, Alt FW, Reth M, Wu H
Structural studies of the phosphoribosyltransferase involved in cobamide biosynthesis in methanogenic archaea and cyanobacteria.
1. Sci Rep - published October 1, 2022
2. Jeter VL, Schwarzwalder AH, Rayment I, Escalante-Semerena JC
Ensemble-function relationships to dissect mechanisms of enzyme catalysis.
1. Sci Adv - published October 1, 2022
2. Yabukarski F, Doukov T, Pinney MM, Biel JT, Fraser JS, Herschlag D
Author Correction: Ectopic JAK-STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance.
1. Nat Cancer - published October 1, 2022
2. Deng S, Wang C, Wang Y, Xu Y, Li X, Johnson NA, Mukherji A, Lo UG, Xu L, Gonzalez J, Metang LA, Ye J, Tirado CR, Rodarte K, Zhou Y, Xie Z, Arana C, Annamalai V, Liu X, Vander Griend DJ, Strand D, Hsieh JT, Li B, Raj G, Wang T, Mu P
The core complex of the Ca²⁺-triggered presynaptic fusion machinery.
1. J Mol Biol - published October 1, 2022
2. Brunger AT, Leitz J
Diving into the complexity of the spirochetal endoflagellum.
1. Trends Microbiol - published October 1, 2022
2. San Martin F, Fule L, Iraola G, Buschiazzo A, Picardeau M
Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling.
1. Elife - published October 1, 2022
2. Barsi-Rhyne B, Manglik A, von Zastrow M
Redox properties and PAS domain structure of the E. coli Energy Sensor Aer indicate a multi-state sensing mechanism.
1. J Biol Chem - published October 1, 2022
2. Maschmann ZA, Chua TK, Chandrasekaran S, Ibáñez H, Crane BR
HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design.
1. Nat Commun - published October 1, 2022
2. Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
A small molecule inhibitor prevents gut bacterial genotoxin production.
1. Nat Chem Biol - published October 1, 2022
2. Volpe MR, Velilla JA, Daniel-Ivad M, Yao JJ, Stornetta A, Villalta PW, Huang HC, Bachovchin DA, Balbo S, Gaudet R, Balskus EP
Structural basis of colibactin activation by the ClbP peptidase.
1. Nat Chem Biol - published October 1, 2022
2. Velilla JA, Volpe MR, Kenney GE, Walsh RM Jr, Balskus EP, Gaudet R
Publisher Correction: Single-sequence protein structure prediction using a language model and deep learning.
1. Nat Biotechnol - published October 1, 2022
2. Chowdhury R, Bouatta N, Biswas S, Floristean C, Kharkar A, Roy K, Rochereau C, Ahdritz G, Zhang J, Church GM, Sorger PK, AlQuraishi M
Inhibited KdpFABC transitions into an E1 off-cycle state.
1. Elife - published October 1, 2022
2. Silberberg JM, Stock C, Hielkema L, Corey RA, Rheinberger J, Wunnicke D, Dubach VRA, Stansfeld PJ, Hänelt I, Paulino C
Proteome effects of genome-wide single gene perturbations.
1. Nat Commun - published October 1, 2022
2. Öztürk M, Freiwald A, Cartano J, Schmitt R, Dejung M, Luck K, Al-Sady B, Braun S, Levin M, Butter F
A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins.
1. Elife - published October 1, 2022
2. Kamal M, Tokmakjian L, Knox J, Mastrangelo P, Ji J, Cai H, Wojciechowski JW, Hughes MP, Takács K, Chu X, Pei J, Grolmusz V, Kotulska M, Forman-Kay JD, Roy PJ
Mechanism of an intramembrane chaperone for multipass membrane proteins.
1. Nature - published October 1, 2022
2. Smalinskaitė L, Kim MK, Lewis AJO, Keenan RJ, Hegde RS
Substrate-driven assembly of a translocon for multipass membrane proteins.
1. Nature - published October 1, 2022
2. Sundaram A, Yamsek M, Zhong F, Hooda Y, Hegde RS, Keenan RJ
Synthesis and Biological Evaluation of Aurachin D Analogues as Inhibitors of Mycobacterium tuberculosis Cytochrome bd Oxidase.
1. ACS Med Chem Lett - published October 1, 2022
2. Lawer A, Tyler C, Hards K, Keighley LM, Cheung CY, Kierek F, Su S, Matikonda SS, McInnes T, Tyndall JDA, Krause KL, Cook GM, Gamble AB
Fluorescence dequenching assay for the activity of TEV protease.
1. Anal Biochem - published October 1, 2022
2. Paththamperuma C, Page RC
Habitat quality dynamics in China's first group of national parks in recent four decades: Evidence from land use and land cover changes.
1. J Environ Manage - published October 1, 2022
2. Chen X, Yu L, Cao Y, Xu Y, Zhao Z, Zhuang Y, Liu X, Du Z, Liu T, Yang B, He L, Wu H, Yang R, Gong P
Starting a new chapter on class Ia ribonucleotide reductases.
1. Curr Opin Struct Biol - published October 1, 2022
2. Levitz TS, Drennan CL
The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands.
1. Mol Cell - published October 1, 2022
2. Wang W, Pyle AM
Structural investigation of eukaryotic cells: From the periphery to the interior by cryo-electron tomography.
1. Adv Biol Regul - published October 1, 2022
2. Wang C, Wojtynek M, Medalia O
Versatile Medium Entropy Ti-Based Bulk Metallic Glass Composites.
1. Materials (Basel) - published October 1, 2022
2. Liu T, Zhao Y, Feng L, Gong P
Viral Hijacking of BET Proteins.
1. Viruses - published October 1, 2022
2. Chen IP, Ott M
What bacterial cell death teaches us about life.
1. PLoS Pathog - published October 1, 2022
2. Johnson AG, Kranzusch PJ
Harnessing Antibody Polyspecificity for Cancer Immunotherapy.
1. Monoclon Antib Immunodiagn Immunother - published October 1, 2022
2. Pashov A, Murali R, Makhoul I, Karbassi B, Kieber-Emmons T
Covalent drugs targeting histidine - an unexploited opportunity?
1. RSC Med Chem - published October 1, 2022
2. Che J, Jones LH
Cryo-EM structures of coagulation factors.
1. Res Pract Thromb Haemost - published October 1, 2022
2. Di Cera E, Mohammed BM, Pelc LA, Stojanovski BM