Member Publications

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112 Member Publications for July 2022

Structural basis of receptor usage by the engineered capsid AAV-PHP.eB.
1. Mol Ther Methods Clin Dev - published July 31, 2022
2. Jang S, Shen HK, Ding X, Miles TF, Gradinaru V
Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors.
1. Commun Biol - published July 30, 2022
2. Rohac R, Crack JC, de Rosny E, Gigarel O, Le Brun NE, Fontecilla-Camps JC, Volbeda A
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2.
1. bioRxiv - published July 28, 2022
2. Gahbauer S, Correy GJ, Schuller M, Ferla MP, Doruk YU, Rachman M, Wu T, Diolaiti M, Wang S, Neitz RJ, Fearon D, Radchenko D, Moroz Y, Irwin JJ, Renslo AR, Taylor JC, Gestwicki JE, von Delft F, Ashworth A, Ahel I, Shoichet BK, Fraser JS
Phylogenetic Classification and Functional Review of Autotransporters.
1. Front Immunol - published July 21, 2022
2. Clarke KR, Hor L, Pilapitiya A, Luirink J, Paxman JJ, Heras B
Approaches to Using the Chameleon: Robust, Automated, Fast-Plunge cryoEM Specimen Preparation.
1. Front Mol Biosci - published July 11, 2022
2. Levitz TS, Weckener M, Fong I, Naismith JH, Drennan CL, Brignole EJ, Clare DK, Darrow MC
Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis.
1. Front Pharmacol - published July 11, 2022
2. Lai Y, Tuvim MJ, Leitz J, Peters J, Pfuetzner RA, Esquivies L, Zhou Q, Czako B, Cross JB, Jones P, Dickey BF, Brunger AT
Hyper-swivel head domain motions are required for complete mRNA-tRNA translocation and ribosome resetting.
1. Nucleic Acids Res - published July 9, 2022
2. Nishima W, Girodat D, Holm M, Rundlet EJ, Alejo JL, Fischer K, Blanchard SC, Sanbonmatsu KY
Protein-protein conjugation enhances immunogenicity of SARS-CoV-2 Receptor Binding Domain (RBD) vaccines.
1. iScience - published July 9, 2022
2. Scaria PV, Rowe CG, Chen BB, Dickey TH, Renn JP, Lambert LE, Barnafo EK, Rausch KM, Tolia NH, Duffy PE
APOBEC mutagenesis and selection for NFE2L2 contribute to the origin of lung squamous-cell carcinoma.
1. Lung Cancer - published July 9, 2022
2. Cannataro VL, Kudalkar S, Dasari K, Gaffney SG, Lazowski HM, Jackson LK, Yildiz I, Das RK, Gould Rothberg BE, Anderson KS, Townsend JP
Signaling Pathways in Neurovascular Development.
1. Annu Rev Neurosci - published July 8, 2022
2. Rattner A, Wang Y, Nathans J
PRC2, Chromatin Regulation, and Human Disease: Insights From Molecular Structure and Function.
1. Front Oncol - published July 8, 2022
2. Liu X, Liu X
The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven mechanism.
1. PLoS Pathog - published July 8, 2022
2. Thorsen MK, Draganova EB, Heldwein EE
Author Correction: Plasticity in ligand recognition at somatostatin receptors.
1. Nat Struct Mol Biol - published July 8, 2022
2. Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G
Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation.
1. Sci Adv - published July 8, 2022
2. Harrison JJEK, Passos DO, Bruhn JF, Bauman JD, Tuberty L, DeStefano JJ, Ruiz FX, Lyumkis D, Arnold E
Author Correction: Bat coronaviruses related to SARS-CoV-2 and infectious for human cells.
1. Nature - published July 7, 2022
2. Temmam S, Vongphayloth K, Baquero E, Munier S, Bonomi M, Regnault B, Douangboubpha B, Karami Y, Chrétien D, Sanamxay D, Xayaphet V, Paphaphanh P, Lacoste V, Somlor S, Lakeomany K, Phommavanh N, Pérot P, Dehan O, Amara F, Donati F, Bigot T, Nilges M, Rey FA, van der Werf S, Brey PT, Eloit M
Modulating mitofusins to control mitochondrial function and signaling.
1. Nat Commun - published July 7, 2022
2. Zacharioudakis E, Agianian B, Kumar Mv V, Biris N, Garner TP, Rabinovich-Nikitin I, Ouchida AT, Margulets V, Nordstrøm LU, Riley JS, Dolgalev I, Chen Y, Wittig AJH, Pekson R, Mathew C, Wei P, Tsirigos A, Tait SWG, Kirshenbaum LA, Kitsis RN, Gavathiotis E
Structural mechanisms of GABA_A receptor autoimmune encephalitis.
1. Cell - published July 7, 2022
2. Noviello CM, Kreye J, Teng J, Prüss H, Hibbs RE
Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis.
1. Infect Immun - published July 7, 2022
2. Pike CM, Tam J, Melnyk RA, Theriot CM
Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases as Antibiofilm Agents in Acute Pulmonary Pseudomonas aeruginosa Infection.
1. Antimicrob Agents Chemother - published July 7, 2022
2. Ostapska H, Raju D, Corsini R, Lehoux M, Lacdao I, Gilbert S, Sivarajah P, Bamford NC, Baker P, Gravelat FN, Howell PL, Sheppard DC
Implications of conformational flexibility, lipid binding, and regulatory domains in cell traversal-protein CelTOS for apicomplexan migration.
1. J Biol Chem - published July 6, 2022
2. Kumar H, Jimah JR, Misal SA, Salinas ND, Fried M, Schlesinger PH, Tolia NH
Gold nanomaterials and their potential use as cryo-electron tomography labels.
1. J Struct Biol - published July 6, 2022
2. Terrence Beales C, Medalia O
Intranasal administration of a live-attenuated recombinant newcastle disease virus expressing the SARS-CoV-2 Spike protein induces high neutralizing antibody levels and protects from experimental challenge infection in hamsters.
1. Vaccine - published July 6, 2022
2. de Swart RL, de Leeuw OS, Oreshkova N, Gerhards NM, Albulescu IC, Vreman S, Gonzales JL, Maas R, van Kuppeveld FJM, Soema P, Bosch BJ, Peeters BPH
Correction: Chaudhuri et al. Diverse Functions of Tim50, a Component of the Mitochondrial Inner Membrane Protein Translocase. Int. J. Mol. Sci. 2021, 22, 7779.
1. Int J Mol Sci - published July 6, 2022
2. Chaudhuri M, Tripathi A, Gonzalez FS
Structure of the human cation-chloride cotransport KCC1 in an outward-open state.
1. Proc Natl Acad Sci U S A - published July 5, 2022
2. Zhao Y, Shen J, Wang Q, Ruiz Munevar MJ, Vidossich P, De Vivo M, Zhou M, Cao E
High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials.
1. Chembiochem - published July 5, 2022
2. Solares MJ, Jonaid GM, Luqiu WY, Berry S, Khadela J, Liang Y, Evans MC, Pridham KJ, Dearnaley WJ, Sheng Z, Kelly DF
Peter J. Roach (1948-2022).
1. Cell Metab - published July 5, 2022
2. Gentry MS, Harris RA, Tagliabracci VS
Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models.
1. Science - published July 5, 2022
2. Cohen AA, van Doremalen N, Greaney AJ, Andersen H, Sharma A, Starr TN, Keeffe JR, Fan C, Schulz JE, Gnanapragasam PNP, Kakutani LM, West AP Jr, Saturday G, Lee YE, Gao H, Jette CA, Lewis MG, Tan TK, Townsend AR, Bloom JD, Munster VJ, Bjorkman PJ
STING controls energy stress-induced autophagy and energy metabolism via STX17.
1. J Cell Biol - published July 4, 2022
2. Rong Y, Zhang S, Nandi N, Wu Z, Li L, Liu Y, Wei Y, Zhao Y, Yuan W, Zhou C, Xiao G, Levine B, Yan N, Mou S, Deng L, Tang Z, Liu X, Kramer H, Zhong Q
Methyl probes in proteins for determining ligand binding mode in weak protein-ligand complexes.
1. Sci Rep - published July 4, 2022
2. Mohanty B, Orts J, Wang G, Nebl S, Alwan WS, Doak BC, Williams ML, Heras B, Mobli M, Scanlon MJ
A roadmap for designing narrow-spectrum antibiotics targeting bacterial pathogens.
1. Microb Cell - published July 4, 2022
2. Cao X, Landick R, Campbell EA
Outer hair cell function is normal in βV spectrin knockout mice.
1. Hear Res - published July 3, 2022
2. Stankewich MC, Bai JP, Stabach PR, Khan S, Tan WJT, Surguchev A, Song L, Morrow JS, Santos-Sacchi J, Navaratnam DS
Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance.
1. Nat Commun - published July 3, 2022
2. Zhuang X, Wang Z, Fan J, Bai X, Xu Y, Chou JJ, Hou T, Chen S, Pan L
Huntingtin turnover: modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550.
1. Hum Mol Genet - published July 3, 2022
2. Lee Y, Kim H, Barker D, Vijayvargia R, Atwal RS, Specht H, Keshishian H, Carr SA, Lee R, Kwak S, Hyun KG, Loupe J, MacDonald ME, Song JJ, Seong IS
Editorial overview: Modern and future methods for studying macromolecular assemblies in action.
1. Curr Opin Struct Biol - published July 3, 2022
2. Brown A, Fraternali F
Listeria monocytogenes two component system PieRS regulates secretion chaperones PrsA1 and PrsA2 and enhances bacterial translocation across the intestine.
1. Mol Microbiol - published July 3, 2022
2. Cahoon LA, Alejandro-Navarreto X, Gururaja AN, Light SH, Alonzo F, Anderson WF, Freitag NE
Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains.
1. Nat Commun - published July 2, 2022
2. Case JB, Mackin S, Errico JM, Chong Z, Madden EA, Whitener B, Guarino B, Schmid MA, Rosenthal K, Ren K, Dang HV, Snell G, Jung A, Droit L, Handley SA, Halfmann PJ, Kawaoka Y, Crowe JE Jr, Fremont DH, Virgin HW, Loo YM, Esser MT, Purcell LA, Corti D, Diamond MS
Tropism of SARS-CoV-2 for human cortical astrocytes.
1. Proc Natl Acad Sci U S A - published July 2, 2022
2. Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Ross J, Parikshak N, Wang S, Zhou L, Koontz M, Velmeshev D, Siebert CV, Gemenes KM, Tabata T, Perez Y, Wang L, Mostajo-Radji MA, de Majo M, Donohue KC, Shin D, Salma J, Pollen AA, Nowakowski TJ, Ullian E, Kumar GR, Winkler EA, Crouch EE, Ott M, Kriegstein AR
Organizing Structural Principles of the Interleukin-17 Ligand-Receptor Axis.
1. Nature - published July 2, 2022
2. Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC
Cryo-EM structure of an active bacterial TIR-STING filament complex.
1. Nature - published July 2, 2022
2. Morehouse BR, Yip MCJ, Keszei AFA, McNamara-Bordewick NK, Shao S, Kranzusch PJ
Neurotensin orchestrates valence assignment in the amygdala.
1. Nature - published July 2, 2022
2. Li H, Namburi P, Olson JM, Borio M, Lemieux ME, Beyeler A, Calhoon GG, Hitora-Imamura N, Coley AA, Libster A, Bal A, Jin X, Wang H, Jia C, Choudhury SR, Shi X, Felix-Ortiz AC, de la Fuente V, Barth VP, King HO, Izadmehr EM, Revanna JS, Batra K, Fischer KB, Keyes LR, Padilla-Coreano N, Siciliano CA, McCullough KM, Wichmann R, Ressler KJ, Fiete IR, Zhang F, Li Y, Tye KM
ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.
1. Nature - published July 2, 2022
2. de Reuver R, Verdonck S, Dierick E, Nemegeer J, Hessmann E, Ahmad S, Jans M, Blancke G, Van Nieuwerburgh F, Botzki A, Vereecke L, van Loo G, Declercq W, Hur S, Vandenabeele P, Maelfait J
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
1. Nat Biotechnol - published July 2, 2022
2. Rothenberger S, Hurdiss DL, Walser M, Malvezzi F, Mayor J, Ryter S, Moreno H, Liechti N, Bosshart A, Iss C, Calabro V, Cornelius A, Hospodarsch T, Neculcea A, Looser T, Schlegel A, Fontaine S, Villemagne D, Paladino M, Schiegg D, Mangold S, Reichen C, Radom F, Kaufmann Y, Schaible D, Schlegel I, Zitt C, Sigrist G, Straumann M, Wolter J, Comby M, Sacarcelik F, Drulyte I, Lyoo H, Wang C, Li W, Du W, Binz HK, Herrup R, Lusvarghi S, Neerukonda SN, Vassell R, Wang W, Adler JM, Eschke K, Nascimento M, Abdelgawad A, Gruber AD, Bushe J, Kershaw O, Knutson CG, Balavenkatraman KK, Ramanathan K, Wyler E, Teixeira Alves LG, Lewis S, Watson R, Haeuptle MA, Zürcher A, Dawson KM, Steiner D, Weiss CD, Amstutz P, van Kuppeveld FJM, Stumpp MT, Bosch BJ, Engler O, Trimpert J
Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration.
1. Nat Commun - published July 2, 2022
2. Gomez-Sintes R, Xin Q, Jimenez-Loygorri JI, McCabe M, Diaz A, Garner TP, Cotto-Rios XM, Wu Y, Dong S, Reynolds CA, Patel B, de la Villa P, Macian F, Boya P, Gavathiotis E, Cuervo AM
Atg23 is a vesicle-tethering protein.
1. Autophagy - published July 2, 2022
2. Leary KA, Hawkins WD, Andhare D, Popelka H, Klionsky DJ, Ragusa MJ
Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer.
1. Proc Natl Acad Sci U S A - published July 2, 2022
2. Brown BP, Zhang YK, Kim S, Finneran P, Yan Y, Du Z, Kim J, Hartzler AL, LeNoue-Newton ML, Smith AW, Meiler J, Lovly CM
Plasmonic Fluor-Enhanced Antigen Arrays for High-Throughput, Serological Studies of SARS-CoV-2.
1. ACS Infect Dis - published July 2, 2022
2. Qavi AJ, Wu C, Lloyd M, Zaman MM, Luan J, Ballman C, Leung DW, Crick SL, Farnsworth CW, Amarasinghe GK
First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation.
1. J Med Chem - published July 2, 2022
2. Sandoval JE, Ramabadran R, Stillson N, Sarah L, Fujimori DG, Goodell MA, Reich N
Molecular mechanism of the severe MH/CCD mutation Y522S in skeletal ryanodine receptor (RyR1) by cryo-EM.
1. Proc Natl Acad Sci U S A - published July 2, 2022
2. Iyer KA, Hu Y, Klose T, Murayama T, Samsó M
Purification and membrane interactions of human KCNQ1_100-370 potassium ion channel.
1. Biochim Biophys Acta Biomembr - published July 2, 2022
2. Dixit G, Stowe RB, Bates A, Jaycox CK, Escobar JR, Harding BD, Drew DL Jr, New CP, Sahu ID, Edelmann RE, Dabney-Smith C, Sanders CR, Lorigan GA
Staphylococcal self-loading helicases couple the staircase mechanism with inter domain high flexibility.
1. Nucleic Acids Res - published July 2, 2022
2. Qiao C, Debiasi-Anders G, Mir-Sanchis I
A Single-Component Luminescent Biosensor for the SARS-CoV-2 Spike Protein.
1. J Am Chem Soc - published July 2, 2022
2. Ravalin M, Roh H, Suryawanshi R, Kumar GR, Pak JE, Ott M, Ting AY
Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys.
1. Nat Microbiol - published July 2, 2022
2. Fenwick C, Turelli P, Ni D, Perez L, Lau K, Herate C, Marlin R, Lana E, Pellaton C, Raclot C, Esteves-Leuenberger L, Campos J, Farina A, Fiscalini F, Dereuddre-Bosquet N, Relouzat F, Abdelnabi R, Foo CS, Neyts J, Leyssen P, Lévy Y, Pojer F, Stahlberg H, LeGrand R, Trono D, Pantaleo G
Structural basis of human TREX1 DNA degradation and autoimmune disease.
1. Nat Commun - published July 2, 2022
2. Zhou W, Richmond-Buccola D, Wang Q, Kranzusch PJ
Structure and Function of Plant and Mammalian TPC Channels.
1. Handb Exp Pharmacol - published July 2, 2022
2. She J, Guo J, Jiang Y
Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
1. J Med Chem - published July 2, 2022
2. Szychowski J, Papp R, Dietrich E, Liu B, Vallée F, Leclaire ME, Fourtounis J, Martino G, Perryman AL, Pau V, Yin SY, Mader P, Roulston A, Truchon JF, Marshall CG, Diallo M, Duffy NM, Stocco R, Godbout C, Bonneau-Fortin A, Kryczka R, Bhaskaran V, Mao D, Orlicky S, Beaulieu P, Turcotte P, Kurinov I, Sicheri F, Mamane Y, Gallant M, Black WC
ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.
1. EMBO J - published July 2, 2022
2. Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R, Weaver VM
NMR Reveals Specific Tracts within the Intrinsically Disordered Regions of the SARS-CoV-2 Nucleocapsid Protein Involved in RNA Encountering.
1. Biomolecules - published July 2, 2022
2. Pontoriero L, Schiavina M, Korn SM, Schlundt A, Pierattelli R, Felli IC
Author Correction: A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.
1. Nat Commun - published July 2, 2022
2. Li T, Cai H, Yao H, Zhou B, Zhang N, van Vlissingen MF, Kuiken T, Han W, GeurtsvanKessel CH, Gong Y, Zhao Y, Shen Q, Qin W, Tian XX, Peng C, Lai Y, Wang Y, Hutter CAJ, Kuo SM, Bao J, Liu C, Wang Y, Richard AS, Raoul H, Lan J, Seeger MA, Cong Y, Rockx B, Wong G, Bi Y, Lavillette D, Li D
Structures of Atm1 provide insight into [2Fe-2S] cluster export from mitochondria.
1. Nat Commun - published July 2, 2022
2. Li P, Hendricks AL, Wang Y, Villones RLE, Lindkvist-Petersson K, Meloni G, Cowan JA, Wang K, Gourdon P
In situ architecture of the ciliary base reveals the stepwise assembly of intraflagellar transport trains.
1. Science - published July 2, 2022
2. van den Hoek H, Klena N, Jordan MA, Alvarez Viar G, Righetto RD, Schaffer M, Erdmann PS, Wan W, Geimer S, Plitzko JM, Baumeister W, Pigino G, Hamel V, Guichard P, Engel BD
Fusion protein strategies for cryo-EM study of G protein-coupled receptors.
1. Nat Commun - published July 2, 2022
2. Zhang K, Wu H, Hoppe N, Manglik A, Cheng Y
Selenocyanate derived Se-incorporation into the Nitrogenase Fe protein cluster.
1. Elife - published July 2, 2022
2. Buscagan TM, Kaiser JT, Rees DC
Functional Studies and Revision of the NFAT-133/TM-123 Biosynthetic Pathway in Streptomyces pactum.
1. ACS Chem Biol - published July 2, 2022
2. Zhou W, Alharbi HA, Hummingbird E, Keatinge-Clay AT, Mahmud T
Ubiquitination drives COPI priming and Golgi SNARE localization.
1. Elife - published July 2, 2022
2. Date SS, Xu P, Hepowit NL, Diab NS, Best J, Xie B, Du J, Strieter ER, Jackson LP, MacGurn JA, Graham TR
Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease.
1. Bioorg Med Chem - published July 2, 2022
2. Yuan X, Jiang H, Fu D, Robida A, Rajanayake K, Yuan H, Wen B, Sun D, Watch BT, Chinnaswamy K, Stuckey JA, Paczesny S, Rech JC, Yang CY
LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells.
1. Protein Cell - published July 1, 2022
2. Sun Z, Yu H, Zhao J, Tan T, Pan H, Zhu Y, Chen L, Zhang C, Zhang L, Lei A, Xu Y, Bi X, Huang X, Gao B, Wang L, Correia C, Chen M, Sun Q, Feng Y, Shen L, Wu H, Wang J, Shen X, Daley GQ, Li H, Zhang J
Investigation of β-Substitution Activity of O-Acetylserine Sulfhydrolase from Citrullus vulgaris.
1. Chembiochem - published July 1, 2022
2. Smith JL, Harrison IM, Bingman CA, Buller AR
PcoB is a defense outer membrane protein that facilitates cellular uptake of copper.
1. Protein Sci - published July 1, 2022
2. Li P, Nayeri N, Górecki K, Becares ER, Wang K, Mahato DR, Andersson M, Abeyrathna SS, Lindkvist-Petersson K, Meloni G, Missel JW, Gourdon P
Comparing methods for immobilizing HIV-1 SOSIPs in ELISAs that evaluate antibody binding.
1. Sci Rep - published July 1, 2022
2. Dam KA, Mutia PS, Bjorkman PJ
Perspectives from a Predominantly African American Community about Biobank Research and a Biobank Consent Form.
1. Ethics Hum Res - published July 1, 2022
2. Sedig LK, De Loney EH, Bailey SB, Spector-Bagdady K, Ghita B, Krienke LK, Hutchinson R
Molecular subclasses of clear cell ovarian carcinoma and their impact on disease behavior and outcomes.
1. Clin Cancer Res - published July 1, 2022
2. Bolton KL, Chen D, Corona de la Fuente RI, Fu Z, Murali R, K Bel M, Tazi Y, Cunningham JM, Chan ICC, Wiley BJ, Moukarzel LA, Winham SJ, Armasu SM, Lester J, Elishaev E, Laslavic A, Kennedy CJ, Piskorz A, Sekowska M, Brand AH, Chiew YE, Pharoah P, Elias KM, Drapkin R, Churchman M, Gourley C, DeFazio A, Karlan B, Brenton JD, Weigelt B, Anglesio MS, Huntsman D, Gayther SA, Konner J, Modugno F, Lawrenson K, Goode EL, Papaemmanuil E
The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation.
1. PLoS Pathog - published July 1, 2022
2. Ginex T, Marco-Marín C, Wieczór M, Mata CP, Krieger J, Ruiz-Rodriguez P, López-Redondo ML, Francés-Gómez C, Melero R, Sánchez-Sorzano CÓ, Martínez M, Gougeard N, Forcada-Nadal A, Zamora-Caballero S, Gozalbo-Rovira R, Sanz-Frasquet C, Arranz R, Bravo J, Rubio V, Marina A, IBV-Covid19-Pipeline., Geller R, Comas I, Gil C, Coscolla M, Orozco M, Llácer JL, Carazo JM
SARS-CoV-2 Infection and Lytic Reactivation of Herpesviruses: a Potential Threat at Post-pandemic Era?
1. J Med Virol - published July 1, 2022
2. Chen J, Song J, Dai L, Post SR, Qin Z
Cryo neutron crystallography demonstrates influence of RNA 2'-OH orientation on conformation, sugar pucker and water structure.
1. Nucleic Acids Res - published July 1, 2022
2. Harp JM, Lybrand TP, Pallan PS, Coates L, Sullivan B, Egli M
Fides: Reliable trust-region optimization for parameter estimation of ordinary differential equation models.
1. PLoS Comput Biol - published July 1, 2022
2. Fröhlich F, Sorger PK
Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels.
1. Nucleic Acids Res - published July 1, 2022
2. Barbari SR, Beach AK, Markgren JG, Parkash V, Moore EA, Johansson E, Shcherbakova PV
CaMKII binds both substrates and activators at the active site.
1. Cell Rep - published July 1, 2022
2. Özden C, Sloutsky R, Mitsugi T, Santos N, Agnello E, Gaubitz C, Foster J, Lapinskas E, Esposito EA, Saneyoshi T, Kelch BA, Garman SC, Hayashi Y, Stratton MM
Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
1. EMBO J - published July 1, 2022
2. Brown ZP, Abaeva IS, De S, Hellen CUT, Pestova TV, Frank J
Structures of the human CST-Polα-primase complex bound to telomere templates.
1. Nature - published July 1, 2022
2. He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim CJ
Structure of the MRAS-SHOC2-PP1C phosphatase complex.
1. Nature - published July 1, 2022
2. Hauseman ZJ, Fodor M, Dhembi A, Viscomi J, Egli D, Bleu M, Katz S, Park E, Jang DM, Porter KA, Meili F, Guo H, Kerr G, Mollé S, Velez-Vega C, Beyer KS, Galli GG, Maira SM, Stams T, Clark K, Eck MJ, Tordella L, Thoma CR, King DA
The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment.
1. Nat Commun - published July 1, 2022
2. Huang Z, Liu H, Nix J, Xu R, Knoverek CR, Bowman GR, Amarasinghe GK, Sibley LD
Reconstitution of a telomeric replicon organized by CST.
1. Nature - published July 1, 2022
2. Zaug AJ, Goodrich KJ, Song JJ, Sullivan AE, Cech TR
Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
1. Nature - published July 1, 2022
2. Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, Yang X, Root DE, Barsotti AM, Stamford AW, Perry CK, Burgin A, McCormick F, Lemke CT, Hahn WC, Aguirre AJ
Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions.
1. Nat Commun - published July 1, 2022
2. Liu M, Huang LZX, Smits AA, Büll C, Narimatsu Y, van Kuppeveld FJM, Clausen H, de Haan CAM, de Vries E
Monomeric prefusion structure of an extremophile gamete fusogen and stepwise formation of the postfusion trimeric state.
1. Nat Commun - published July 1, 2022
2. Feng J, Dong X, Su Y, Lu C, Springer TA
Structures of β₁-adrenergic receptor in complex with Gs and ligands of different efficacies.
1. Nat Commun - published July 1, 2022
2. Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells.
1. Cell Chem Biol - published July 1, 2022
2. Mehta S, Buyanbat A, Kai Y, Karayel O, Goldman SR, Seruggia D, Zhang K, Fujiwara Y, Donovan KA, Zhu Q, Yang H, Nabet B, Gray NS, Mann M, Fischer ES, Adelman K, Orkin SH
A proteomic approach identifies isoform-specific and nucleotide-dependent RAS interactions.
1. Mol Cell Proteomics - published July 1, 2022
2. Miller SP, Maio G, Zhang X, Badillo Soto FS, Zhu J, Ramirez SZ, Lin H
A Simple, Affordable, and Rapid Visual CRISPR-Based Field Test for Sex Determination of Earlier Porcine Embryos and Pork Products.
1. Mol Biotechnol - published July 1, 2022
2. Tao D, Liu J, Li Q, Jiang Y, Xu B, Khazalwa EM, Gong P, Xu J, Ma Y, Ruan J, Niu L, Xie S
A One-tube Rapid Visual CRISPR Assay for The Field Detection of Japanese Encephalitis Virus.
1. Virus Res - published July 1, 2022
2. Xu B, Gong P, Zhang Y, Wang Y, Tao D, Fu L, Khazalwa EM, Liu H, Zhao S, Zhang X, Xie S
Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability.
1. Structure - published July 1, 2022
2. Shi W, Wang L, Zhou T, Sastry M, Yang ES, Zhang Y, Chen M, Chen X, Choe M, Creanga A, Leung K, Olia AS, Pegu A, Rawi R, Schön A, Shen CH, Stancofski ED, Talana CA, Teng IT, Wang S, Corbett KS, Tsybovsky Y, Mascola JR, Kwong PD
Drug independence and the curability of cancer by combination chemotherapy.
1. Trends Cancer - published July 1, 2022
2. Pomeroy AE, Schmidt EV, Sorger PK, Palmer AC
Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity.
1. Nat Commun - published July 1, 2022
2. Zhang Z, Xun Y, Rong S, Yan L, SoRelle JA, Li X, Tang M, Keller K, Ludwig S, Moresco EMY, Beutler B
Principles of Alternating Access in LeuT-fold Transporters: Commonalities and Divergences.
1. J Mol Biol - published July 1, 2022
2. Del Alamo D, Meiler J, Mchaourab HS
RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons.
1. Prog Neurobiol - published July 1, 2022
2. Van der Linden RJ, Gerritsen J, Liao M, Widomska J, Pearse RV 2nd, White FM, Franke B, Young-Pearse TL, Poelmansa G
In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding.
1. PLoS Pathog - published July 1, 2022
2. Bate N, Savva CG, Moody PCE, Brown EA, Evans SE, Ball JK, Schwabe JWR, Sale JE, Brindle NPJ
Single-Particle Cryo-EM Data Collection with Stage Tilt using Leginon.
1. J Vis Exp - published July 1, 2022
2. Aiyer S, Strutzenberg TS, Bowman ME, Noel JP, Lyumkis D
Update on the systematic review/meta-analysis of uncomplicated bone metastases treated with external beam radiation.
1. Radiother Oncol - published July 1, 2022
2. Behroozian T, Navarro I, Hoskin P, Johnstone C, Recht A, Menten J, Oldenburger E, van der Linden Y, van der Velden JM, Nguyen QN, Simone CB, Johnstone P, Lutz S, Milton L, Andratschke N, Willmann J, Kazmierska J, Spałek M, Chow E, Raman S
Molecular Basis for Variations in the Sensitivity of Pathogenic Rhodopsin Variants to 9-cis-Retinal.
1. J Biol Chem - published July 1, 2022
2. Roushar FJ, McKee AG, Kuntz CP, Ortega JT, Penn WD, Woods H, Chamness LM, Most V, Meiler J, Jastrzebska B, Schlebach JP
Structural basis for the activation and ligand recognition of the human oxytocin receptor.
1. Nat Commun - published July 1, 2022
2. Waltenspühl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Plückthun A
Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3.
1. Nat Struct Mol Biol - published July 1, 2022
2. Fry MY, Najdrová V, Maggiolo AO, Saladi SM, Doležal P, Clemons WM Jr
Author Correction: LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding.
1. Nat Biotechnol - published July 1, 2022
2. Ludwig KU, Schmithausen RM, Li D, Jacobs ML, Hollstein R, Blumenstock K, Liebing J, Słabicki M, Ben-Shmuel A, Israeli O, Weiss S, Ebert TS, Paran N, Rüdiger W, Wilbring G, Feldman D, Lippke B, Ishorst N, Hochfeld LM, Beins EC, Kaltheuner IH, Schmitz M, Wöhler A, Döhla M, Sib E, Jentzsch M, Moench EC, Borrajo JD, Strecker J, Reinhardt J, Cleary B, Geyer M, Hölzel M, Macrae R, Nöthen MM, Hoffmann P, Exner M, Regev A, Zhang F, Schmid-Burgk JL
A bivalent SARS-CoV-2 monoclonal antibody combination does not impact the immunogenicity of a vector-based COVID-19 vaccine in macaques.
1. Sci Transl Med - published July 1, 2022
2. Nkolola JP, Yu J, Wan H, Chang A, McMahan K, Anioke T, Jacob-Dolan C, Powers O, Ye T, Chandrashekar A, Sellers D, Barrett J, Loo YM, Esser MT, Carnahan RH, Crowe JE Jr, Barouch DH
The protein organization of a red blood cell.
1. Cell Rep - published July 1, 2022
2. Sae-Lee W, McCafferty CL, Verbeke EJ, Havugimana PC, Papoulas O, McWhite CD, Houser JR, Vanuytsel K, Murphy GJ, Drew K, Emili A, Taylor DW, Marcotte EM
Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices.
1. Sci Adv - published July 1, 2022
2. Akyuz N, Karavitaki KD, Pan B, Tamvakologos PI, Brock KP, Li Y, Marks DS, Corey DP
NK cells with tissue-resident traits shape response to immunotherapy by inducing adaptive antitumor immunity.
1. Sci Transl Med - published July 1, 2022
2. Kirchhammer N, Trefny MP, Natoli M, Brücher D, Smith SN, Werner F, Koch V, Schreiner D, Bartoszek E, Buchi M, Schmid M, Breu D, Hartmann KP, Zaytseva P, Thommen DS, Läubli H, Böttcher JP, Stanczak MA, Kashyap AS, Plückthun A, Zippelius A
The two-domain elevator-type mechanism of zinc-transporting ZIP proteins.
1. Sci Adv - published July 1, 2022
2. Wiuf A, Steffen JH, Becares ER, Grønberg C, Mahato DR, Rasmussen SGF, Andersson M, Croll T, Gotfryd K, Gourdon P
Mutagenesis of the Loop 3 α-Helix of Neisseria gonorrhoeae TdfJ Inhibits S100A7 Binding and Utilization.
1. mBio - published July 1, 2022
2. Maurakis SA, Stoudenmire JL, Rymer JK, Chazin WJ, Cornelissen CN
Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells.
1. bioRxiv - published July 1, 2022
2. Chew K, Lee B, van Haren SD, Nanishi E, O'Meara T, Splaine JB, DeLeon M, Soni D, Seo HS, Dhe-Paganon S, Ozonoff A, Smith JA, Levy O, Dowling DJ
Human immunodeficiency virus type 2 capsid protein mutagenesis reveals amino acid residues important for virus particle assembly.
1. J Mol Biol - published July 1, 2022
2. Yang H, Talledge N, Arndt WG, Zhang W, Mansky LM
Accelerating PERx Reaction Enables Covalent Nanobodies for Potent Neutralization of SARS-Cov-2 and Variants.
1. Chem - published July 1, 2022
2. Yu B, Li S, Tabata T, Wang N, Cao L, Kumar GR, Sun W, Liu J, Ott M, Wang L
Predicting Systemic Health Features from Retinal Fundus Images Using Transfer-Learning-Based Artificial Intelligence Models.
1. Diagnostics (Basel) - published July 1, 2022
2. Khan NC, Perera C, Dow ER, Chen KM, Mahajan VB, Mruthyunjaya P, Do DV, Leng T, Myung D