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30 Member Publications for June 2026

Previous Month

Hit-to-Lead Optimization of Energy-Coupling Factor (ECF) Transporter Inhibitors as Novel Antibiotic.
1. J Med Chem - published June 6, 2026
2. Exapicheidou I, Tsarenko A, Zeller L, Ibrahim H, Baumann C, Shams A, Hoffmann PA, Li Y, Kany AM, Hermann J, Slotboom DJ, Müller R, Volkamer A, Hamed MM, Diamanti E, Hirsch AKH
Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating.
1. Sci Adv - published June 5, 2026
2. Vaisey G, MacKinnon R
Century of Progress on the Structure of APOB-100 in Atherogenic Lipoproteins.
1. Circ Res - published June 5, 2026
2. Coleman B, Woollett LA, Davidson WS
Evaluating beta-tubulin variants as predictors of benzimidazole resistance across Caenorhabditis nematodes.
1. PLoS Pathog - published June 5, 2026
2. Shaver AO, McKeown R, Reyes Otero JM, Collins JB, Hogan DW, Fraser JS, Dreyer SM, Ragsdale EJ, Andersen EC
An S752D activation loop mutation dynamically primes Muscle-Specific Kinase (MuSK) for activation.
1. Biochem J - published June 4, 2026
2. Prömer JJ, Murphy JW, Lemmon MA, Tsutsui Y, Herbst R
Prolonged zinc exposure modulates biofilm metabolic activity and conjugation in Enterococcus faecalis.
1. BMC Microbiol - published June 4, 2026
2. Fenclova D, Hrazdilova K, Coufalova M, Ter Beek J, Berntsson RP, Zurek L, Cihalova K
Structural dynamics of kappa opioid receptor interactions with β-arrestin 1.
1. Nat Commun - published June 4, 2026
2. Han J, Fine EJ, Jiang Q, Zhuang Y, Suomivuori CM, Chen ZW, Denn E, Whiddon K, Li K, Evers AS, Fuller J, Carter J, Fay JF, Chen M, Dror RO, Che T
Cisplatin resistance in an ovarian cancer model is mediated by microtubule dynamics regulator TPPP3 in synergy with tubulin code rewiring.
1. Cell Rep - published June 4, 2026
2. Horibata S, Mahalingan KK, Patel R, Fan Y, Hotz JM, Ponton-Almodovar A, MacRenaris K, Li Y, Meerzaman D, Gottesman MM, Roll-Mecak A
A cross-vertebrate brain protein interaction map identifies conserved neural and non-neural complexes.
1. Cell Rep - published June 4, 2026
2. Dang V, Voigt B, Yang D, Hoogerbrugge G, Lee M, Cox RM, Papoulas O, McWhite CD, Pradeep R, Leggere JC, Neely BA, Gray RS, Marcotte EM
Neutralizing antibodies elicited in nonhuman primates by an enterovirus D68 virus-like particle vaccine target receptor binding sites.
1. Sci Transl Med - published June 3, 2026
2. Moss DL, Cheng J, Krug PW, Paine AC, Fisher BE, Henry AR, Roberts-Torres J, Johnston TS, Smith SC, Pletnev S, Lei H, Morano NC, Pierson TC, Shapiro L, Zhou T, Kwong PD, Douek DC, Kanekiyo M, Ruckwardt TJ
LpxC activity regulation: An emerging paradigm for controlling lipopolysaccharide synthesis.
1. Trends Microbiol - published June 3, 2026
2. Nathawat R, Liu C, Mi W
A GUV-based assay to reconstitute membrane tethering in vitro.
1. Mol Biol Cell - published June 3, 2026
2. Andhare D, Ragusa MJ
Tubulin flux at spastin-induced nanodamage sites regulates microtubule rescue frequency and EB1 lifetimes.
1. Proc Natl Acad Sci U S A - published June 2, 2026
2. Szczesna E, Spector JO, Sarbanes SL, Chen J, Szyk A, Roll-Mecak A
Plant cell wall-plasma membrane attachments mediate stress resilience through cellulose synthase complexes and remorins.
1. Cell - published June 2, 2026
2. Rui Y, Zaoralová M, Dwyer WP, Reyes AV, Grismer TS, Abel NB, Jayachandran D, Chundawat SPS, Ott T, Kieber JJ, Dahlberg PD, Xu SL, Dinneny JR
Structural Response of Pohlianin C to Heterocyclic Graft Incorporation.
1. J Org Chem - published June 2, 2026
2. Širvinskas MJ, Ou YD, Saunders GJ, Yudin AK
Comprehensive mapping of human CD4(+) T cell epitopes for Nipah and measles as prototype Paramyxoviruses.
1. Cell Rep Med - published June 2, 2026
2. Tarke A, Macias M, Morales CF, Michaelis T, Siddiqui L, Yu ED, Trevizani R, Zuniga A, Zmasek C, Phillips E, Mallal S, Lin B, Estevez JO, Erlich JR, Johnson NV, McLellan JS, Frazier A, da Silva Antunes R, Tan GS, Grifoni A, Sette A
Functional diversity of phage sponge proteins that sequester host immune signals.
1. Nat Microbiol - published June 2, 2026
2. Hadary R, Chang RB, Béchon N, Tal N, Osterman I, Yirmiya E, Garb J, Rivera ML, Amitai G, Kranzusch PJ, Sorek R
High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.
1. Proc Natl Acad Sci U S A - published June 2, 2026
2. Yang D, Wang X, Liu J, Gong Y, Nair P, Sun J, Qian X, Cui J, Zeng H, Dong A, Harding RJ, Burgess-Brown N, Beyett TS, Song D, Krause HM, Diamond ML, Bolhuis DL, Brown NG, Arrowsmith CH, Edwards AM, Halabelian L, Peng H
Loss of Payload Sensitivity and Other Mechanisms of Resistance to T-DXd in HER2-Mutant NSCLC: Implications for Subsequent Responsiveness to HER2 TKIs.
1. J Thorac Oncol - published June 1, 2026
2. Nilsson MB, Le X, Poteete A, Yu X, He J, Huang Q, Shibata Y, Liu X, Moran C, Alizadeh AA, Diehn M, Wakelee H, Almanza D, Soltys S, Sugio T, Mutter J, Kang X, Wang R, Jun S, Esfahani MS, Tran H, Xi Y, Hong L, Huo X, Kumar A, Ren X, Oguchi K, Minamiguchi K, Weipert CM, Wang J, Kittler R, Heymach JV
Insights into retinal disease and non-tubulin glutamylation from a RPGR-TTLL5 complex structure.
1. J Cell Biol - published June 1, 2026
2. Park JH, Liu RJY, Sun X, Mahalingan KK, Hiriyanna S, Li T, Roll-Mecak A
Antibody-mediated diversification of primary and secondary humoral immune responses.
1. J Exp Med - published June 1, 2026
2. Schaefer-Babajew D, Binet L, Silva Santos GS, Ruprecht C, Deimel LP, ElTanbouly MA, Gharrassi D, Lima Dos Reis G, Uhe C, Yao KH, Hernandez B, Agrawal P, Gazumyan A, Stamatatos L, Hartweger H, Nussenzweig MC
Analysis of the heterogenous structural states of the hexameric ATPase PilU of the type IV pili from Vibrio cholerae.
1. Protein Sci - published June 1, 2026
2. Guo Y, Shukla S, Minasov G, Inniss NL, Klose T, Tokars VL, Mondragón A, Otwinowski Z, Borek D, Satchell KJF
Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B.
1. Acta Crystallogr D Struct Biol - published June 1, 2026
2. He Z, Chen S, Micheli F, Cianciulli A, Beato C, Ellman J, Ha Y
Structural basis for dimerization, catalytic regulation, and substrate selectivity of the chloroplast S9D CGEP protease in Arabidopsis thaliana.
1. Protein Sci - published June 1, 2026
2. Ehrlich JJ, Routray P, Enns L, van Wijk KJ, Kawate T
Cellular and molecular representations: Following the lesson of David Goodsell.
1. Protein Sci - published June 1, 2026
2. Zoppè M, Williams VCJ, Briegel A
PIP4K2A/2B inhibitor suppresses tumor growth in a xenograft model of NSCLC.
1. iScience - published June 1, 2026
2. He Z, Chen S, Bosenberg M, Muthusamy V, Xi Y, Wang H, Micheli F, Cianciulli A, Beato C, Van Zandt M, Ellman J, Ha Y
Structure of the E3 ligase CRL2(ZYG11B) with substrates reveals the molecular basis for N-degron recognition and ubiquitination.
1. Cell Rep - published June 1, 2026
2. Liu X, Li Y, Castro LK, Yu Z, Cheng Y, Daugherty MD, Gross JD
Targeting BRD2 and BRD4 inhibit the growth of KSHV-infected immortalized endothelial cells through suppression of LANA translation.
1. PLoS Pathog - published June 1, 2026
2. Chen J, Fan J, Qin M, Lin Z, Mu S, Dai L, Qin Z
Generation of membrane-permeable cyclic peptides inhibiting protein-protein interaction.
1. Nat Chem Biol - published June 1, 2026
2. Ji X, Farrera-Soler L, Li J, Sangouard G, De Sadeleer N, Nielsen AL, Mothukuri GK, Zarda A, Will EJ, Pojer F, Lau K, Heinis C
Design, synthesis and evaluation of an uncharged broad spectrum quinoline-oxime hybrid for the reactivation of nerve agent-inhibited human acetylcholinesterase.
1. Eur J Med Chem - published June 1, 2026
2. De Sousa J, Calas AG, De La Mora E, Landry C, Hanak AS, Maryan-Instone A, Gastellier AJ, Coisne C, Courageux C, Hachani J, Gosselet F, Dehouck MP, Rousseau C, Timperley CM, Weik M, Nachon F, Brown RCD, Baati R, Dias J