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59 Member Publications for April 2026

Previous Month

Iridoids from Traditional Chinese Medicine for Neuropathic Pain: Therapeutic Potential and Molecular Mechanisms.
1. Drug Des Devel Ther - published April 14, 2026
2. Wang W, Liu T, Ding Y, Liu X, Qingji R, Zhang Y, Zhang Z
Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causing autoimmune diseases through autoantibody production.
1. Front Immunol - published April 13, 2026
2. Suzuki K, Arteaga-Vazquez LJ, Villalobos Reveles B, Hernández-Espinosa L, López-Moyado IF, Onodera A, Samaniego-Castruita D, Ay F, Lara-Custodio A, Hogan PG, Sepulveda H, Rao A
Nucleocytoplasmic Transport.
1. Annu Rev Biochem - published April 9, 2026
2. Mobbs GW, Petrovic S, Hoelz A
The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.
1. Nat Chem Biol - published April 9, 2026
2. Chana CK, Ben Makhlouf I, Kim J, Yu AJY, Moatti N, Orlicky S, Wong CJ, Baronijan L, Tang X, Mao D, Larsen B, McGary L, Seale B, Mader P, Ceccarelli DF, Barbulescu P, Martin A, Durocher D, Pelletier L, Gingras AC, Sicheri F
Species- and variant-specific ACE2 compatibility shapes SARS-CoV-2 spillover potential in North American cervids.
1. Nat Commun - published April 9, 2026
2. Espada C, Ye K, Long Y, Pasai K, DeLiberto TJ, Heale J, Wiese R, Yang Q, Zhou M, Streich S, Tao YJ, Chandler JC, Wan XF
An Asgard archaeon from a modern analog of ancient microbial mats.
1. Curr Biol - published April 9, 2026
2. Nobs SJ, Johnson MD, Williams TJ, Meltzer J, Vázquez-Campos X, MacLeod FI, Rowell K, Pitt M, Paul B, Shepherd DC, Michie KA, Duggin IG, Ghosal D, Burns BP
Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state.
1. Nat Struct Mol Biol - published April 8, 2026
2. Zehr EA, Sun S, Sarbanes SL, Roll-Mecak A
Skeletal editing via multi-step engineering of a modular polyketide synthase.
1. Nat Commun - published April 8, 2026
2. Kudo K, Hashimoto T, Awakawa T, Zhang L, Nishimura T, Hashimoto J, Kozone I, Kagaya N, Suenaga H, Keatinge-Clay AT, Abe I, Shin-Ya K
The LOK C-Terminus is an IBAR-like Domain that Facilitates Membrane Binding and Ezrin Colocalization.
1. Biophys J - published April 8, 2026
2. Beiter JR, Vasiliauskas D, Hodge GM, Schneiderman HE, Pillon MC, Iyer SS, Mendoza MC, Lombardo AT, Voth GA
Single-molecule dissection of CFTR folding defects and pharmacological rescue.
1. Proc Natl Acad Sci U S A - published April 7, 2026
2. Kim SA, Levring J, Chen J, Yoon TY
Structures of folding intermediates on BAM show diverse substrates fold by a conserved mechanism.
1. Proc Natl Acad Sci U S A - published April 7, 2026
2. Thomson BD, Marquez MD, Rawson S, Dos Santos TMA, Harrison SC, Kahne D
Leveraging Kinase Drugs for Neurosciences: Discovery of Selective, CNS-Penetrant Reversible Bruton's Tyrosine Kinase Inhibitors as Therapeutics for Neuroinflammation.
1. J Med Chem - published April 7, 2026
2. Hopkins BT, Marx IE, Vandeveer HG, Nevalainen M, Basile R, Bajrami B, Choi CK, Grater RJ, Gu C, Hoemberger M, Kadakia E, Kapadnis SK, Liu Y, Ma B, Magee T, Metrick CM, Mingueneau M, Muste CA, Parker Harp CR, Prince RJ, Santoro JC, Schulz J, Sciabola S, Tang H, Wang T, Meissner R, Bohnert T
Evolutionary tuning of an auditory transduction channel.
1. Curr Biol - published April 6, 2026
2. Akyuz N, Scott TJ, Loeb C, Pan B, Li Y, Phillips CB, Bellono NW, Corey DP
Charged molecular glue discovery enabled by targeted degron display.
1. Nat Chem Biol - published April 6, 2026
2. Zhuang Z, Byun WS, Chrustowicz J, Kozicka Z, Li VL, Abeja DM, Donovan KA, Sepic S, You I, Słabicki M, Fischer ES, Hinshaw SM, Ebert BL, Schulman BA, Gray NS
DPY30 is an epigenetic decoupler linking replication stress to immunoediting in pancreatic cancer.
1. Cancer Res - published April 6, 2026
2. Citron F, Cecchetto L, Granato E, Ho IL, Liu Z, Balestrieri C, Yen EY, Perelli L, Zhang L, Castillo Montanez LA, Dyke CA, Shah R, Attanasio S, Srinivasan S, Roy S, Kwon HJ, Blazanin N, Chen Y, Chen KC, Chen Z, Scognamiglio I, Pham N, Jiang S, Pan J, Leung CS, Wang L, Gao S, Carugo A, Wang H, Yao W, Tonon G, Bonini MC, Zal MA, Jeter C, Tainer JA, Heffernan TP, Giuliani V, Lissanu Y, Genovese G, Di Pilato M, Viale A, Schlacher K, Draetta GF
Mechanisms of human mitochondrial leaderless mRNA translation initiation.
1. Nat Commun - published April 4, 2026
2. Shen S, Xu Y, Kober DL, Wang J
Nonlinear stiffness of NompC gating spring and its implication in mechanotransduction.
1. Sci Adv - published April 3, 2026
2. Wang Y, Jin P, Kumar A, Jan L, Cheng Y, Jan YN, Zhang Y
Multimerizing transcription factors FOXP3 and AIRE as chromatin architectural regulators.
1. Nat Immunol - published April 3, 2026
2. Leng F, Huoh YS, Hur S
Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer.
1. Sci Immunol - published April 3, 2026
2. Liu X, Huang R, Ku Z, Xie J, Chen H, He Y, Lou Q, Zhang C, Yang X, Lewis C, Homsi J, Gupta A, Dong L, Chen K, Tu A, Du L, Yu H, Hu Q, Fang M, Li B, Khan AEMA, Simith C, John S, Xu L, Zhang N, An Z, Zhang CC
Molecular mechanisms of immune evasion by host protein glycosylation of a bacterial immunogen used in nucleic acid vaccines.
1. J Biol Chem - published April 2, 2026
2. Cinar MS, Adams TM, Nawaz Z, Demir ES, Demirturk ME, Keelaghan AP, Nazaar SM, Roberts BR, Ozdilek A, Avci FY
PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and Gα(q).
1. bioRxiv - published April 1, 2026
2. Falzone ME, Banerjee P, MacKinnon R
Structural and mechanistic basis of ADAR1-mediated RNA editing and immune regulation.
1. Cell Insight - published April 1, 2026
2. Deng X, Elsharkawy M, Gao Y
Automated workflows for strategy computation and data collection at synchrotron beamlines.
1. Acta Crystallogr D Struct Biol - published April 1, 2026
2. Fogh RH, Keller P, Flensburg C, Vonrhein C, Paciorek W, Carter L, Bricogne G
A µ-opioid receptor superagonist analgesic with minimal adverse effects.
1. Nature - published April 1, 2026
2. Gomez JL, Ventriglia EN, Frangos ZJ, Sulima A, Robertson MJ, Sacco MD, Budinich RC, Giosan IM, Xie T, Solis O, Tischer AE, Bossert JM, Caldwell KE, Bonbrest H, Essmann A, Garçon-Poca ZM, Choi S, Noya MR, Limiac F, Arce A, Glatfelter GC, Robinson M, Chen L, Mullarkey AA, Brademan DR, Enten G, Dunne W, Quiroz C, Schoenborn I, Lee CB, Rais R, Holt DP, Dannals RF, Shi L, Hüttenhain R, Ferré S, Kiyatkin E, Bonaventura J, Shaham Y, Zachariou V, Baumann MH, Skiniotis G, Rice KC, Michaelides M
Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation.
1. Signal Transduct Target Ther - published April 1, 2026
2. Zhang K, He L, Wang Y, Qin S, Yu C, Zheng E, Zhang Z, Xu Y, Chen X, Liu Y, Liu X, Guan S, Xia L, Suo F, Pei F, Du J, Su Y, Li Y, Wu Y, Zhou X, Zhou J, Cai L, Tang X, Zhang Z, Shang Y, Zhang Q, Gong K, Sun L
A luciferase-based hRBC-NSG mouse model to evaluate anti-CelTOS transmission-blocking antibodies against P. falciparum.
1. Malar J - published April 1, 2026
2. Xu S, Roth AE, Thomson-Luque R, Salinas N, Barnes S, Herman C, Tolia NH, Adams JH
Multiplexed antigen panel analysis identifies B cell phenotype and receptor genetic contributions to antibody breadth.
1. Immunity - published April 1, 2026
2. Wirz OF, Kotagiri P, Haraguchi E, Röltgen K, Hunter M, Craig E, Afaghani J, Lee JY, Nielsen SCA, Hoh RA, Pursell T, Arunachalam PS, Manohar M, Chang I, Schuetz JP, Lam B, Fernandes A, Do E, Smith D, Ha B, Liao L, Najeeb J, Otrelo-Cardoso AR, Ho C, Wohlstadter JN, Sigal GB, Jardetzky TS, Scott SA, Van Slyck S, Davis MM, Pulendran B, Minshull J, Pinsky BA, Nadeau KC, Niemann CU, Yang F, Boyd SD
CGM23 corresponds to a pan-coronavirus lipopeptide inhibitor potently inhibiting virion fusion.
1. iScience - published April 1, 2026
2. Matsui Y, Schwarzer R, Montano M, Helmy EW, Suryawanshi RK, Taha TY, Wang Y, Angel Y, Adler M, Sassano MF, Jo H, Tarran R, Ott M, Greene WC
Proteome-wide prediction of interactions between structured domains and peptide motifs reveals functionally coherent subnetworks.
1. Proc Natl Acad Sci U S A - published April 1, 2026
2. Saha A, Tang CL, Murray D, Honig B
Antagonism by the type VI secretion system of Bacteroides fragilis is controlled by a TetR family regulator and released small molecule.
1. Proc Natl Acad Sci U S A - published April 1, 2026
2. Tuzlak L, Pappas TE, Coyne MJ, Sheahan ML, Burgo V, Rice PA, Comstock LE
Cetacean coronavirus spikes highlight S glycoprotein structural plasticity.
1. PLoS Pathog - published April 1, 2026
2. Hulswit RJG, Shamorkina TM, van der Lee J, Rosman F, Wetzels LS, van Kuppeveld FJM, Snijder J, Bosch BJ, Hurdiss DL
Pulmonary neuroendocrine cell-derived exosomes regulate iron homeostasis and oxidative stress in lung neurons.
1. Sci Adv - published April 1, 2026
2. Thakur A, Zhang K, Chen J, Mei S, Chen J, Verdiell A, Jacobs E, Mulder L, Whitford A, Iyaswamy A, Chen YW, Cliffe A, Esser-Kahn A, Chen B, Lian Q, Solway J, Xing S, Chen HJ
Structure basis for C-C chemokine receptor 4 modulation by orthosteric and allosteric antagonists.
1. Proc Natl Acad Sci U S A - published April 1, 2026
2. Zhou N, Wang R, Chen B, Qi X
Intratumoral T(reg) cell ablation elicits NK cell-mediated control of CD8 T cell-resistant tumors.
1. Sci Immunol - published April 1, 2026
2. Zhang C, Chien C, Jurgaitytė E, Sakiyama K, Bockman A, Jo Y, Lee S, Silveria S, Andrews E, Mende A, Zhang L, Garcia KC, Wagner A, DuPage M, Raulet D
Mechanism of lipid-dependent cold sensitivity in a model ion channel.
1. Nat Commun - published April 1, 2026
2. Li CC, Nimigean CM
SRC-mediated phosphorylation of UBC9 regulates inflammatory and metabolic signaling in alcohol-associated liver disease.
1. Sci Adv - published April 1, 2026
2. Chandla S, Lim Y, Floris A, Mazarei M, Yang X, Tsuchiya T, Dagar M, Darmawan A, Justo M, Murali R, Gangi A, Tomasi I, Mavila N, Ramani K, Tomasi ML
The Conformational Switches of a Bacterial Light-Driven Sodium Pump Characterized by Time-Resolved Resonance Raman Spectroscopy.
1. Chemphyschem - published April 1, 2026
2. Schäfer AL, Silapetere A, Hegemann P, Forest KT, Kuhlmann U, Hildebrandt P
Combining structural modeling and deep learning to calculate the E. coli protein interactome and functional networks.
1. Nat Commun - published April 1, 2026
2. Zhao H, Velez C, Naravane A, Saha A, Feldman J, Skolnick J, Murray D, Honig B
Plant NLRs are getting into higher-order architectures.
1. Plant J - published April 1, 2026
2. Kim N, Chae E, Song JJ
Nuclear basket subunits Nup211 and Rsm1 influence RNA 3'-processing and transcription termination in fission yeast.
1. RNA - published April 1, 2026
2. Bednor L, Innokentev A, Sanchez AM, Sem A, Schwer B, Shuman S
A metal ion-dependent mechanism promoting gain of function in NEIL1 variants.
1. Int J Radiat Biol - published April 1, 2026
2. Zuckerman JT, Minko IG, Lybrand TP, Egli M, McCullough AK, Lloyd RS
Comparative characterization of Cas12f orthologs reveals mechanistic features underlying enhanced genome editing efficiency.
1. Nat Struct Mol Biol - published April 1, 2026
2. Guan K, Ocampo RF, Matheus Carnevali PB, Castelle CJ, Gonzalez-Osorio L, Castanzo DT, Thomas NC, Brothers M, Dangerfield TL, Hooper MM, West MS, Appleby NM, Krudop I, Lamothe RC, Aliaga Goltsman DS, Alexander LM, Butterfield CN, Johnson KA, Brown CT, Taylor DW
Structural basis for allosteric regulation of mycobacterial guanosine 5´-monophosphate reductase by ATP and GTP.
1. Nat Commun - published April 1, 2026
2. Doležal M, Knejzlík Z, Kouba T, Filimoněnko A, Šváchová H, Dedola M, Klíma M, Pichová I
A universal cis-proline lock defines catalysis in thioredoxin-fold enzymes.
1. Commun Biol - published April 1, 2026
2. Cunliffe T, Wang G, Penning S, Subedi P, Totsika M, Paxman JJ, Heras B
Targeting the Zika virus envelope domains I and III as a recombinant vaccine protects mice from lethal challenge.
1. NPJ Vaccines - published April 1, 2026
2. Dussupt V, Jensen JL, Rosado AP, Donofrio M, Pflugheber J, Mendez-Rivera L, Sankhala RS, Chen WH, Slike BM, Schmid A, Tran U, Metzger L, Peterson CE, Pinto AK, Vasan S, Collins ND, Farmer A, Michael NL, Joyce MG, Brien JD, Krebs SJ
Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes.
1. Nature - published April 1, 2026
2. Kılıç ZI, van Loenhout J, Chaillet M, van Es RM, Alcaraz PS, Vos HR, Noteborn WEM, Leung MR
Zanubrutinib and pirtobrutinib show synergistic killing and suppression of BTK signaling in MYD88-mutated lymphoma cells.
1. Blood Adv - published April 1, 2026
2. Pizzarella D, Kofides A, Hatcher JM, Liu X, Guijosa A, Tsakmaklis N, Peachey A, Wang J, Guerrera ML, Patterson CJ, Hunter ZR, Sun H, Sarosiek S, Castillo JJ, Buhrlage S, Dhe-Paganon S, Branagan AR, Treon SP, Liu S
Histone diversity in the archaeal domain of life.
1. Nat Commun - published April 1, 2026
2. Laursen SP, Luger K
Activation mechanism of the full-length histidine kinase LvrB from pathogenic Leptospira.
1. Nat Commun - published April 1, 2026
2. Agustoni E, Mechaly A, Dalla Rizza J, Beriashvili D, Pluhackova K, Isaikina P, Trajtenberg F, Müntener T, Wunder EA Jr, Ko AI, Schirmer T, Buschiazzo A, Hiller S
Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape.
1. Science - published April 1, 2026
2. Springstein BL, Javoor MG, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL, Schur FKM, Loose M
B lymphocyte protein factories produced by hematopoietic stem cell gene editing.
1. Science - published April 1, 2026
2. Hartweger H, Ruprecht C, Yao KH, Laffont P, Lima Dos Reis G, Zhou P, Hägglöf T, Binet L, Loewe M, Hong JP, Xiao T, Sefik E, Hernandez B, Gazumyan A, Jankovic M, Seaman MS, Costa G, Nelson SA, Clark J, Kanatani S, Wilson PC, Krammer F, Levashina EA, Julien JP, Wardemann H, Sinnis P, Stamatatos L, Flavell RA, Nussenzweig MC
Gut Microbiota of Gray Snub-Nosed Monkeys: Adaptation to Seasonal Variations Through Energy Compensation and Thermogenesis.
1. Integr Zool - published April 1, 2026
2. Sun Y, Zhang M, Wang X, Huang X, Yu Y, Pan H, Li H, Shi L, Yang W, Zhang C, Ding B, Liu X, Li J, Qian C, Cheng B, Zhang C, Ran J, Li M
Cryo-EM structures of higher order Gephyrin oligomers reveal principles of inhibitory postsynaptic scaffold organization.
1. Nat Commun - published April 1, 2026
2. Ortiz-López D, Hove TT, Huhn C, Camuso S, van Gen Hassend PM, Sander B, Campbell BFN, Tyagarajan SK, Plückthun A, Specht CG, Maric HM, Böttcher B, Schindelin H
Distinguishing cancer patients' mild and severe symptoms in radiotherapy via zero-shot and few-shot large language model-based probabilistic prompts.
1. BioData Min - published April 1, 2026
2. Chen MW, Yan Y, Shen X, Gao H, Chen Z
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis.
1. Nat Cell Biol - published April 1, 2026
2. Liu S, Gad M, Li C, Cho K, Liu Y, Wangdu K, Belay V, Millet A, Kojima H, Sanford H, Wölk M, Urnavicius L, Fedorova M, Patti GJ, Vinogradova EV, Hite RK, Birsoy K
Calcium dependent activation of the TMEM16F scramblase and ion channel.
1. Nat Struct Mol Biol - published April 1, 2026
2. Feng Z, Alvarenga OE, Di Zanni E, Lee S, Khelashvili G, Accardi A
A High-Throughput Fluorescence Polarization Assay for Screening Sirtuin Inhibitors.
1. ACS Chem Biol - published April 1, 2026
2. Peng K, Chakraborty S, Jin Y, Lin H
Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.
1. Nucleic Acids Res - published April 1, 2026
2. Chickering T, Harp JM, Jiang Y, Qin J, He G, Hyde S, Ihlefeld A, Janas M, O'Flaherty DK, Schofield S, Szeto J, Theile CS, Charissé K, Jadhav V, Maier MA, Manoharan M, Egli M, Schlegel MK
Discovery of actinators, actin-derived bioactive peptides that modulate cytoskeleton and actin-related cellular activities.
1. Sci Adv - published April 1, 2026
2. Yi F, Guo J, Vo TT, Hetrick B, Haikerwal A, Zhou Z, Sealey L, He S, Han Y, Chilin L, Spear M, Yu D, Kim Y, Kashanchi F, Zhou T, Xu X, Lockhart C, Wu Y