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128 Member Publications for April 2026

Correction: Discovery and optimization of tau targeted protein degraders enabled by patient induced pluripotent stem cells-derived neuronal models of tauopathy.
1. Front Cell Neurosci - published April 23, 2026
2. Silva MC, Nandi G, Donovan KA, Cai Q, Berry BC, Nowak RP, Fischer ES, Gray NS, Ferguson FM, Haggarty SJ
Iridoids from Traditional Chinese Medicine for Neuropathic Pain: Therapeutic Potential and Molecular Mechanisms.
1. Drug Des Devel Ther - published April 14, 2026
2. Wang W, Liu T, Ding Y, Liu X, Qingji R, Zhang Y, Zhang Z
Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causing autoimmune diseases through autoantibody production.
1. Front Immunol - published April 13, 2026
2. Suzuki K, Arteaga-Vazquez LJ, Villalobos Reveles B, Hernández-Espinosa L, López-Moyado IF, Onodera A, Samaniego-Castruita D, Ay F, Lara-Custodio A, Hogan PG, Sepulveda H, Rao A
Nucleocytoplasmic Transport.
1. Annu Rev Biochem - published April 9, 2026
2. Mobbs GW, Petrovic S, Hoelz A
The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.
1. Nat Chem Biol - published April 9, 2026
2. Chana CK, Ben Makhlouf I, Kim J, Yu AJY, Moatti N, Orlicky S, Wong CJ, Baronijan L, Tang X, Mao D, Larsen B, McGary L, Seale B, Mader P, Ceccarelli DF, Barbulescu P, Martin A, Durocher D, Pelletier L, Gingras AC, Sicheri F
Species- and variant-specific ACE2 compatibility shapes SARS-CoV-2 spillover potential in North American cervids.
1. Nat Commun - published April 9, 2026
2. Espada C, Ye K, Long Y, Pasai K, DeLiberto TJ, Heale J, Wiese R, Yang Q, Zhou M, Streich S, Tao YJ, Chandler JC, Wan XF
An Asgard archaeon from a modern analog of ancient microbial mats.
1. Curr Biol - published April 9, 2026
2. Nobs SJ, Johnson MD, Williams TJ, Meltzer J, Vázquez-Campos X, MacLeod FI, Rowell K, Pitt M, Paul B, Shepherd DC, Michie KA, Duggin IG, Ghosal D, Burns BP
Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state.
1. Nat Struct Mol Biol - published April 8, 2026
2. Zehr EA, Sun S, Sarbanes SL, Roll-Mecak A
Skeletal editing via multi-step engineering of a modular polyketide synthase.
1. Nat Commun - published April 8, 2026
2. Kudo K, Hashimoto T, Awakawa T, Zhang L, Nishimura T, Hashimoto J, Kozone I, Kagaya N, Suenaga H, Keatinge-Clay AT, Abe I, Shin-Ya K
The LOK C-Terminus is an IBAR-like Domain that Facilitates Membrane Binding and Ezrin Colocalization.
1. Biophys J - published April 8, 2026
2. Beiter JR, Vasiliauskas D, Hodge GM, Schneiderman HE, Pillon MC, Iyer SS, Mendoza MC, Lombardo AT, Voth GA
Structural Basis of Polypurine Track Strand Displacement by HIV-1 Reverse Transcriptase.
1. bioRxiv - published April 8, 2026
2. Wen X, Lee R, Muppalla SD, McFadden WM, Kirby KA, Dick RA, Sarafianos SG
Comparative analysis of flavivirus sfRNA dynamics and secondary structure.
1. bioRxiv - published April 8, 2026
2. Bair CR, VanInsberghe D, Lowen AC, Conn GL, Neufeldt CJ
Molecular basis for ligand-gating of the human GluD1 receptor.
1. bioRxiv - published April 8, 2026
2. Mondal AK, Wang H, Weaver MG, Zheng I, Kormshchikov N, Ahmed F, Twomey EC
Single-molecule dissection of CFTR folding defects and pharmacological rescue.
1. Proc Natl Acad Sci U S A - published April 7, 2026
2. Kim SA, Levring J, Chen J, Yoon TY
Structures of folding intermediates on BAM show diverse substrates fold by a conserved mechanism.
1. Proc Natl Acad Sci U S A - published April 7, 2026
2. Thomson BD, Marquez MD, Rawson S, Dos Santos TMA, Harrison SC, Kahne D
Leveraging Kinase Drugs for Neurosciences: Discovery of Selective, CNS-Penetrant Reversible Bruton's Tyrosine Kinase Inhibitors as Therapeutics for Neuroinflammation.
1. J Med Chem - published April 7, 2026
2. Hopkins BT, Marx IE, Vandeveer HG, Nevalainen M, Basile R, Bajrami B, Choi CK, Grater RJ, Gu C, Hoemberger M, Kadakia E, Kapadnis SK, Liu Y, Ma B, Magee T, Metrick CM, Mingueneau M, Muste CA, Parker Harp CR, Prince RJ, Santoro JC, Schulz J, Sciabola S, Tang H, Wang T, Meissner R, Bohnert T
RNA polymerase inhibitors reveal active-site motions essential for the nucleotide-addition cycle.
1. bioRxiv - published April 7, 2026
2. Dhingra Y, Landick R, Campbell EA, Darst SA
Evolutionary tuning of an auditory transduction channel.
1. Curr Biol - published April 6, 2026
2. Akyuz N, Scott TJ, Loeb C, Pan B, Li Y, Phillips CB, Bellono NW, Corey DP
Charged molecular glue discovery enabled by targeted degron display.
1. Nat Chem Biol - published April 6, 2026
2. Zhuang Z, Byun WS, Chrustowicz J, Kozicka Z, Li VL, Abeja DM, Donovan KA, Sepic S, You I, Słabicki M, Fischer ES, Hinshaw SM, Ebert BL, Schulman BA, Gray NS
DPY30 is an epigenetic decoupler linking replication stress to immunoediting in pancreatic cancer.
1. Cancer Res - published April 6, 2026
2. Citron F, Cecchetto L, Granato E, Ho IL, Liu Z, Balestrieri C, Yen EY, Perelli L, Zhang L, Castillo Montanez LA, Dyke CA, Shah R, Attanasio S, Srinivasan S, Roy S, Kwon HJ, Blazanin N, Chen Y, Chen KC, Chen Z, Scognamiglio I, Pham N, Jiang S, Pan J, Leung CS, Wang L, Gao S, Carugo A, Wang H, Yao W, Tonon G, Bonini MC, Zal MA, Jeter C, Tainer JA, Heffernan TP, Giuliani V, Lissanu Y, Genovese G, Di Pilato M, Viale A, Schlacher K, Draetta GF
Human antibodies against West Nile and related orthoflaviviruses.
1. bioRxiv - published April 6, 2026
2. Rincón TC, Frckova T, Contejean ZI, Cantergiani J, Groen K, Cena B, Moro SG, Bianchini F, Simonelli L, Jarrossay D, Tosolini S, Kuratli R, Robinson ARE, Cizkova M, Niejadlik EG, Moritz J, Thakur R, Krátka Z, Mijatović D, Grujić J, Holoubek J, Budakov-Obradović Z, Salat J, Hönig V, Vraneš M, Lojpur Z, Lendak D, Sević S, Bajči M, Popović-Dragonjić L, Jovicic BP, Gavrilovic J, Kapoor T, MacDonald MR, Bournazos S, Varani L, Palus M, Hale BG, Banović P, Ruzek D, Barnes CO, Robbiani DF
Structural principles of transcriptional collisions.
1. bioRxiv - published April 6, 2026
2. Watters JW, Mueller AU, Ju X, Chuquimarca SJ, Ye HJ, Darst SA, Alushin GM, Liu S
Mechanisms of human mitochondrial leaderless mRNA translation initiation.
1. Nat Commun - published April 4, 2026
2. Shen S, Xu Y, Kober DL, Wang J
Nonlinear stiffness of NompC gating spring and its implication in mechanotransduction.
1. Sci Adv - published April 3, 2026
2. Wang Y, Jin P, Kumar A, Jan L, Cheng Y, Jan YN, Zhang Y
Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer.
1. Sci Immunol - published April 3, 2026
2. Liu X, Huang R, Ku Z, Xie J, Chen H, He Y, Lou Q, Zhang C, Yang X, Lewis C, Homsi J, Gupta A, Dong L, Chen K, Tu A, Du L, Yu H, Hu Q, Fang M, Li B, Khan AEMA, Simith C, John S, Xu L, Zhang N, An Z, Zhang CC
Multimerizing transcription factors FOXP3 and AIRE as chromatin architectural regulators.
1. Nat Immunol - published April 3, 2026
2. Leng F, Huoh YS, Hur S
Cryo-EM Structure of Human ATAD2B Reveals a Hexameric Organization Contributes to ATPase Activity and Substrate Coordination.
1. bioRxiv - published April 3, 2026
2. Malone KL, Chua EYD, Lignos JM, Fagnant PM, Macfarlane JE, Trybus KM, Cianfrocco MA, Glass KC
Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers.
1. Elife - published April 3, 2026
2. Yu X, He Y, Kamenecka TM, Kojetin DJ
Unbend, correction of local beam-induced sample motion in cryo-EM images using a 3D spline model.
1. Elife - published April 3, 2026
2. Kong L, Zottig X, Elferich J, Grigorieff N
Protective human antibodies against Powassan virus.
1. J Virol - published April 3, 2026
2. Fallon G, Muraro SP, Ailsworth S, Hui S, Malonis RJ, Tse AL, Miller EH, Chandran K, Fremont DH, Diamond MS, Lai JR
Hypervariable loop profiling decodes sequence determinants of antibody stability.
1. Nat Struct Mol Biol - published April 3, 2026
2. Wan Y, Liang J, Dai Y, Srinivasan K, Billesbølle C, Zhu JF, Shin JE, Paul S, Marks D, Song YS, Myers BR, Koehl A, Manglik A
Bivalent mRNA booster encoding virus-like particles elicits potent polyclass receptor-binding domain antibodies in pre-vaccinated mice.
1. Elife - published April 3, 2026
2. Fan C, Cohen AA, Dam KA, Rorick AV, Priso Fils AI, Yang Z, Gnanapragasam PNP, Segovia LN, Huey-Tubman KE, Moon WJ, Lin PJC, Bjorkman PJ, Hoffmann MAG
Structural basis for multi-subunit DNA-dependent RNA polymerase catalytic activity.
1. Mol Cell - published April 3, 2026
2. Mueller AU, Darst SA
mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines elicits distinct antibody epitope signatures.
1. Cell Rep - published April 3, 2026
2. Cohen AA, Keeffe JR, Manasyan L, Madireddy I, Priso Fils AI, Dam KA, Stober HE, Hills RA, Moon WJ, Lin PJC, Howarth MR, Hoffmann MAG, Bjorkman PJ
Molecular mechanisms of immune evasion by host protein glycosylation of a bacterial immunogen used in nucleic acid vaccines.
1. J Biol Chem - published April 2, 2026
2. Cinar MS, Adams TM, Nawaz Z, Demir ES, Demirturk ME, Keelaghan AP, Nazaar SM, Roberts BR, Ozdilek A, Avci FY
High-throughput biochemical phenotyping of SHP2 variants reveals the molecular basis of diseases and allosteric drug inhibition.
1. bioRxiv - published April 2, 2026
2. Lee AA, Mokhtari DA, Egan ED, Blacklow SC, Herschlag D, Fordyce PM
Conserved stem-loops of the SARS-CoV-2 5'-UTR activate OAS1.
1. bioRxiv - published April 2, 2026
2. Oviedo A, Bair CR, Vasilakopoulos AP, Regis K, Vanlnsberghe D, Lowen AC, Conn GL
Catching our breath: development of interventions and therapies for respiratory syncytial virus.
1. Microbiol Mol Biol Rev - published April 2, 2026
2. Mathew AM, Neilsen G, Lan S, Shooter SL, Zheng JSJ, Estes J, Cao D, Schinazi RF, Singh US, Liang B, Lee S, Sarafianos SG
DNA deformability in sequence-dependent capture of E. coli gyrase.
1. Nat Commun - published April 2, 2026
2. Baker ML, Johnson HR, Eckerty RA, Fogg JM, Summers SL, Vayssières M, Marechal N, Lamour V, Olson WK, Zechiedrich L
Molecular mechanism of cleavage at R271 during prothrombin activation revealed by cryo-EM.
1. Blood - published April 2, 2026
2. Stojanovski B, Mohammed BM, Basore K, Di Cera E
Structural basis of QueC-family protein function in qatABCD anti-phage defense.
1. Nat Commun - published April 2, 2026
2. Gao A, Wassarman DR, Kranzusch PJ
Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells.
1. Cell - published April 2, 2026
2. Rathore U, Dugan E, Thornton H, Kumar VE, Dajani R, Burdick RC, Young JM, Steinhart Z, Lao R, Delviks-Frankenberry KA, Choi W, Henriques WS, Echeverria I, Dann E, Dureja I, Pathak N, Arce MM, McKetney J, Umhoefer JM, Parulekar S, Schmidt R, Polacco BJ, Neidleman J, Montano M, Nguyen VQ, Sali A, Levy JA, Tenthorey JL, Cheng Y, Roan NR, Swaney DL, Kaake RM, Dodgson SE, Hiatt J, Pathak VK, Malik HS, Krogan NJ, Marson A
Trk1 potassium transport is crucial for effective Candidozyma auris skin colonization.
1. Proc Natl Acad Sci U S A - published April 2, 2026
2. Glawe AJ, Eix EF, Johnson CJ, Zarnowski R, Andes MK, Lazarcik J, Henzler-Wildman KA, Nett JE
Kidney tissue characterization using normalized raman imaging and segment-anything.
1. Sci Rep - published April 2, 2026
2. Karmakar R, Trim WV, Kirschner MW, Nørrelykke SF
Structure-guided optimization of SLC1A1/EAAT3-selective inhibitors targeting renal cancer metabolism.
1. EMBO J - published April 2, 2026
2. Koochaki P, Qiu B, Coker JA, Earsley A, Wang NS, Romigh T, Goins CM, Salem C, Mi D, Days E, Bauer JA, Stauffer SR, Boudker O, Chakraborty AA
Newton's cradle-like allosteric mechanism explains regulatory RsmE RNA binding.
1. Nat Commun - published April 2, 2026
2. Finol E, Damberger FF, Krepl M, Flügel T, Dietrich P, Michaels TCT, Vögeli B, Šponer J, Allain FH
NEK7 Cys298 is important for NLRP3 inflammasome and targetable by dimethyl fumarate.
1. Cell Chem Biol - published April 2, 2026
2. Zhang Y, Lindner H, So B, Chen Z, Li H, Xu J, Wang J, Xu J, Petre AM, Distefano MD, Núñez G, Lin H
QW-5-70 targets the colchicine site and demonstrates antitumor activity in P-gp-overexpressing cancer models.
1. Mol Cancer Ther - published April 2, 2026
2. Xie Y, Hou R, Albadari N, Chen H, Miller DJ, Quadrozzi Gruntz J, Oldham ML, Kamal MS, Jiang J, Wu Z, Miller DD, Li W
LEGO®-inspired electrically-actuated microfluidics for on-chip protein crystallization and in situ X-ray crystallography.
1. Lab Chip - published April 2, 2026
2. Saha S, Chen L, Budziszewski GR, Koprek S, Seifert K, Cohen A, Russi S, Bowman SEJ, Perry SL
RNA-induced PRC2 inhibition depends on the sequence of bound RNA.
1. Nat Commun - published April 2, 2026
2. Song J, Yao L, Gooding AR, Thron V, Hemphill WO, Goodrich KJ, Erbse AH, Kasinath V, Cech TR
Engineered Modular Polyketide Synthases Elucidate How Enoylreductases Collaborate with Downstream Acyl Carrier Proteins and Ketosynthases to Set Stereocenters.
1. J Am Chem Soc - published April 2, 2026
2. Zhang J, Bista R, Keatinge-Clay AT
QW-5-70 Targets the Colchicine Site and Demonstrates Antitumor Activity in P-gp-Overexpressing Cancer Models.
1. Mol Cancer Ther - published April 2, 2026
2. Xie Y, Hou R, Albadari N, Chen H, Miller DJ, Quadrozzi Gruntz J, Oldham ML, Kamal MS, Jiang J, Wu Z, Miller DD, Li W
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22.
1. Nat Commun - published April 2, 2026
2. Robertson KC, Amann SJ, Liu T, Funk AV, Wang X, Grishkovskaya I, Mehmood A, Tabor JR, Norris-Drouin JL, Arrowsmith CH, Collins JL, Miao Y, Emanuele MJ, Haselbach D, James LI, Brown NG
Structural basis for ADAM17 activation by the iRhom1 pseudoprotease.
1. Cell Rep - published April 2, 2026
2. Ungvary JN, Maciag JJ, Alnajjar HF, Dávila EM, Slone CE, Thomas JE, Rich MF, Carazo SA, Ifergan I, Perez-Aguilar JM, Blobel CP, Seegar TCM
In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer.
1. Nat Commun - published April 2, 2026
2. Harvey EP, Smith JS, Hurley JD, Granados AJ, Schmid EW, Liang-Lin JG, Zhang H, Meara EM, Wren EK, Paul S, Ferguson MP, Calvillo-Miranda VG, Alcantar MA, Marks DS, Walter JC, Kruse AC, Susa KJ
Monoclonal antibodies against nitrated nerve growth factor reveal an oxidation-dependent pathogenic hallmark in ALS.
1. Proc Natl Acad Sci U S A - published April 2, 2026
2. Varela V, Garcimartín S, Trias E, Zeida A, Richter M, de León A, Miquel E, King PH, Vulliez-Le Normand B, Martinez M, Alzari PM, Bartesaghi S, Radi R, Barbeito L
Author Correction: A µ-opioid receptor superagonist analgesic with minimal adverse effects.
1. Nature - published April 2, 2026
2. Gomez JL, Ventriglia EN, Frangos ZJ, Sulima A, Robertson MJ, Sacco MD, Budinich RC, Giosan IM, Xie T, Solis O, Tischer AE, Bossert JM, Caldwell KE, Bonbrest H, Essmann A, Garçon-Poca ZM, Choi S, Noya MR, Limiac F, Arce A, Glatfelter GC, Robinson M, Chen L, Mullarkey AA, Brademan DR, Enten G, Dunne W, Quiroz C, Schoenborn I, Lee CB, Rais R, Holt DP, Dannals RF, Shi L, Hüttenhain R, Ferré S, Kiyatkin E, Bonaventura J, Shaham Y, Zachariou V, Baumann MH, Skiniotis G, Rice KC, Michaelides M
Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets.
1. Cell - published April 2, 2026
2. Munguba H, Arefin A, Hasegawa R, Posa L, Romano GR, Peddada TN, Donatelle A, Singh A, Gutzeit VA, Vijay A, Vaddi P, Kristt M, Shaver D, Hoque S, Broichhagen J, Stujenske JM, Lee FS, O'Brien E, Levitz J, Liston C
Structural Dynamics and Allosteric Communication of a SARS-Like Bat Coronavirus Spike Glycoprotein.
1. Biophys J - published April 2, 2026
2. Balogun TA, Kearns FL, Calvó-Tusell C, Tse AL, Acreman CM, Casalino L, Lasso G, Happy Miller E, Chandran K, McLellan JS, Amaro RE
Structures of partially occupied hetero-tetramers provide insight into kainate receptor activation and desensitization.
1. Nat Commun - published April 2, 2026
2. Khanra NK, Strauss A, Moreno Wasielewski L, Lenze S, Meyerson J, Reiner A, Levitz J
How interdiction of inositol pyrophosphate catabolism perturbs the fission yeast response to phosphate starvation.
1. Nucleic Acids Res - published April 2, 2026
2. Babor J, Sanchez AM, Prucker I, Jessen HJ, Schwer B, Shuman S
Nuclease-NTPase antiphage defence systems use conserved molecular features to control bacterial immunity.
1. Nat Microbiol - published April 2, 2026
2. Ragucci AE, Antine SP, Leviss EM, Mooney SE, Garcia JM, Shyrokova L, Hauryliuk V, Lee ASY, Kranzusch PJ
Molecular mechanisms and biotechnology applications of CRISPR-Cas12a.
1. Nat Rev Mol Cell Biol - published April 2, 2026
2. Saha A, Ocampo RF, Wright JT, Taylor DW, Palermo G
Protective immunity against malaria by a nanoparticle CIS43-based junctional vaccine alone or in combination with R21.
1. NPJ Vaccines - published April 2, 2026
2. Tripathi P, Koo JH, Chen X, Silva Pereira LD, Dillon M, Zhang B, Lofgren M, Nguyen KT, Teng IT, Bonilla B, Kerscher S, Kong WP, Henry AR, Stephens T, Tsybovsky Y, Weldon SR, Douek DC, Pierson TC, Batista FD, Idris AH, Seder RA, Kwong PD, Zhou T
Generation of mixed-valency, modular multispecific antibodies using disulfide-linked Fc-FcγR complexes.
1. Nat Commun - published April 2, 2026
2. Park M, Ly K, Parcutela B, Choi H, Ladra C, Gonzalez A, Jewel Y, Kang H, Valerio M, Krishnan A, Synold TW, Nguyen LXT, Marcucci G, Williams JC
Orchestrated and dynamic nucleotide addition cycle during respiratory syncytial virus early-stage elongation.
1. Nat Commun - published April 2, 2026
2. Cao D, Chen Z, Gao Y, Roesler C, Gooneratne I, Mera C, Zhuang L, Slack J, Nudell-Cook E, Vy J, Berry J, Royal M, Shaik M, Youngs R, Liang B
Target discrimination and PAM profiling of the Thermotoga maritima type I-B CRISPR system.
1. Biochem J - published April 2, 2026
2. Mallon J, Lenihan CJ, Shridhar S, Bailey S
Contemporary design of small-molecule kinase modulators: orthosteric, allosteric and induced-proximity strategies.
1. Nat Rev Drug Discov - published April 2, 2026
2. Rudolph J, Hoeflich KP, Dar AC
Structure and enzymology of glutaminase S482C and H461L variants associated with excess brain glutamate and neurological disease.
1. J Biol Chem - published April 2, 2026
2. Crane CS, McIssac TK, Milano SK, Cerione RA, Ulrich SM
Assay-Based High Throughput Screening of Diverse Libraries Identifies Selective Inhibitors of Staphylococcus aureus Ribonuclease P.
1. ACS Chem Biol - published April 2, 2026
2. Joshi SS, Huynh LT, Kalia N, Eaton-Landau G, Aponick A, Pyle AM, Harris ME
GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.
1. Nature - published April 2, 2026
2. Liskiewicz D, Novikoff A, Khalil A, Akindehin S, Campbell JE, Candela P, Castelino RL, Coupland C, Culot M, Dodson WS, Douros JD, Embring H, Feuchtinger A, Finan B, Garcia-Caceres C, Gao XB, Gosselet F, Grandl G, Gutgesell RM, Haas DT, Jastroch M, Karaoglu E, Kakimoto P, Kaltenbach AC, Keuper M, Kusminski CM, Leander DC, Liskiewicz A, Liu X, Maity-Kumar G, Martinez SM, Mowery SA, Nogueiras R, Paisley M, Perez-Tilve D, Petersen PSS, Pfluger PT, Prakash S, Steffens S, Cebrian-Serrano A, Tost M, Wean J, Weber C, Yoshida J, Gerhart-Hines Z, Horvath TL, Scherer PE, Seeley RJ, DiMarchi RD, Tschöp MH, Krahmer N, Knerr PJ, Müller TD
ErbB family receptor dimerization dynamics and dysregulation via long-term single-molecule imaging.
1. Cell - published April 2, 2026
2. Ma K, Ma X, Shida JF, Niu Z, Lin YK, Mandal S, Dobbins A, Golomb L, Eck MJ, Greulich H, Meyerson M, Peng CS
Repurposing drug screen for the identification of helicase inhibitors from viruses of pandemic concern.
1. SLAS Discov - published April 2, 2026
2. Inniss NL, Rzhetskaya M, Kich RP, Gleason E, Taha TY, Zapatero-Belinchón FJ, Rosecrans J, Pedrero-Classen V, Huang K, Degotte G, Lizzadro L, Pattie J, Renslo AR, Minasov G, Ott M, Bachta KER, Satchell KJF, Hultquist JF
PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and Gα(q).
1. bioRxiv - published April 1, 2026
2. Falzone ME, Banerjee P, MacKinnon R
Structural and mechanistic basis of ADAR1-mediated RNA editing and immune regulation.
1. Cell Insight - published April 1, 2026
2. Deng X, Elsharkawy M, Gao Y
Automated workflows for strategy computation and data collection at synchrotron beamlines.
1. Acta Crystallogr D Struct Biol - published April 1, 2026
2. Fogh RH, Keller P, Flensburg C, Vonrhein C, Paciorek W, Carter L, Bricogne G
A µ-opioid receptor superagonist analgesic with minimal adverse effects.
1. Nature - published April 1, 2026
2. Gomez JL, Ventriglia EN, Frangos ZJ, Sulima A, Robertson MJ, Sacco MD, Budinich RC, Giosan IM, Xie T, Solis O, Tischer AE, Bossert JM, Caldwell KE, Bonbrest H, Essmann A, Garçon-Poca ZM, Choi S, Noya MR, Limiac F, Arce A, Glatfelter GC, Robinson M, Chen L, Mullarkey AA, Brademan DR, Enten G, Dunne W, Quiroz C, Schoenborn I, Lee CB, Rais R, Holt DP, Dannals RF, Shi L, Hüttenhain R, Ferré S, Kiyatkin E, Bonaventura J, Shaham Y, Zachariou V, Baumann MH, Skiniotis G, Rice KC, Michaelides M
Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation.
1. Signal Transduct Target Ther - published April 1, 2026
2. Zhang K, He L, Wang Y, Qin S, Yu C, Zheng E, Zhang Z, Xu Y, Chen X, Liu Y, Liu X, Guan S, Xia L, Suo F, Pei F, Du J, Su Y, Li Y, Wu Y, Zhou X, Zhou J, Cai L, Tang X, Zhang Z, Shang Y, Zhang Q, Gong K, Sun L
A luciferase-based hRBC-NSG mouse model to evaluate anti-CelTOS transmission-blocking antibodies against P. falciparum.
1. Malar J - published April 1, 2026
2. Xu S, Roth AE, Thomson-Luque R, Salinas N, Barnes S, Herman C, Tolia NH, Adams JH
Multiplexed antigen panel analysis identifies B cell phenotype and receptor genetic contributions to antibody breadth.
1. Immunity - published April 1, 2026
2. Wirz OF, Kotagiri P, Haraguchi E, Röltgen K, Hunter M, Craig E, Afaghani J, Lee JY, Nielsen SCA, Hoh RA, Pursell T, Arunachalam PS, Manohar M, Chang I, Schuetz JP, Lam B, Fernandes A, Do E, Smith D, Ha B, Liao L, Najeeb J, Otrelo-Cardoso AR, Ho C, Wohlstadter JN, Sigal GB, Jardetzky TS, Scott SA, Van Slyck S, Davis MM, Pulendran B, Minshull J, Pinsky BA, Nadeau KC, Niemann CU, Yang F, Boyd SD
CGM23 corresponds to a pan-coronavirus lipopeptide inhibitor potently inhibiting virion fusion.
1. iScience - published April 1, 2026
2. Matsui Y, Schwarzer R, Montano M, Helmy EW, Suryawanshi RK, Taha TY, Wang Y, Angel Y, Adler M, Sassano MF, Jo H, Tarran R, Ott M, Greene WC
Proteome-wide prediction of interactions between structured domains and peptide motifs reveals functionally coherent subnetworks.
1. Proc Natl Acad Sci U S A - published April 1, 2026
2. Saha A, Tang CL, Murray D, Honig B
Antagonism by the type VI secretion system of Bacteroides fragilis is controlled by a TetR family regulator and released small molecule.
1. Proc Natl Acad Sci U S A - published April 1, 2026
2. Tuzlak L, Pappas TE, Coyne MJ, Sheahan ML, Burgo V, Rice PA, Comstock LE
Pulmonary neuroendocrine cell-derived exosomes regulate iron homeostasis and oxidative stress in lung neurons.
1. Sci Adv - published April 1, 2026
2. Thakur A, Zhang K, Chen J, Mei S, Chen J, Verdiell A, Jacobs E, Mulder L, Whitford A, Iyaswamy A, Chen YW, Cliffe A, Esser-Kahn A, Chen B, Lian Q, Solway J, Xing S, Chen HJ
Cetacean coronavirus spikes highlight S glycoprotein structural plasticity.
1. PLoS Pathog - published April 1, 2026
2. Hulswit RJG, Shamorkina TM, van der Lee J, Rosman F, Wetzels LS, van Kuppeveld FJM, Snijder J, Bosch BJ, Hurdiss DL
Structure basis for C-C chemokine receptor 4 modulation by orthosteric and allosteric antagonists.
1. Proc Natl Acad Sci U S A - published April 1, 2026
2. Zhou N, Wang R, Chen B, Qi X
Intratumoral T(reg) cell ablation elicits NK cell-mediated control of CD8 T cell-resistant tumors.
1. Sci Immunol - published April 1, 2026
2. Zhang C, Chien C, Jurgaitytė E, Sakiyama K, Bockman A, Jo Y, Lee S, Silveria S, Andrews E, Mende A, Zhang L, Garcia KC, Wagner A, DuPage M, Raulet D
Mechanism of lipid-dependent cold sensitivity in a model ion channel.
1. Nat Commun - published April 1, 2026
2. Li CC, Nimigean CM
SRC-mediated phosphorylation of UBC9 regulates inflammatory and metabolic signaling in alcohol-associated liver disease.
1. Sci Adv - published April 1, 2026
2. Chandla S, Lim Y, Floris A, Mazarei M, Yang X, Tsuchiya T, Dagar M, Darmawan A, Justo M, Murali R, Gangi A, Tomasi I, Mavila N, Ramani K, Tomasi ML
The Conformational Switches of a Bacterial Light-Driven Sodium Pump Characterized by Time-Resolved Resonance Raman Spectroscopy.
1. Chemphyschem - published April 1, 2026
2. Schäfer AL, Silapetere A, Hegemann P, Forest KT, Kuhlmann U, Hildebrandt P
The cytoplasmic lattice in mammalian eggs sequesters ubiquitination machinery and tubulin in reserve.
1. bioRxiv - published April 1, 2026
2. Li Y, Zheng W, Leem J, Wu C, Tang S, Mogessie B, Xiong Y
Combining structural modeling and deep learning to calculate the E. coli protein interactome and functional networks.
1. Nat Commun - published April 1, 2026
2. Zhao H, Velez C, Naravane A, Saha A, Feldman J, Skolnick J, Murray D, Honig B
Comparative characterization of Cas12f orthologs reveals mechanistic features underlying enhanced genome editing efficiency.
1. Nat Struct Mol Biol - published April 1, 2026
2. Guan K, Ocampo RF, Matheus Carnevali PB, Castelle CJ, Gonzalez-Osorio L, Castanzo DT, Thomas NC, Brothers M, Dangerfield TL, Hooper MM, West MS, Appleby NM, Krudop I, Lamothe RC, Aliaga Goltsman DS, Alexander LM, Butterfield CN, Johnson KA, Brown CT, Taylor DW
A metal ion-dependent mechanism promoting gain of function in NEIL1 variants.
1. Int J Radiat Biol - published April 1, 2026
2. Zuckerman JT, Minko IG, Lybrand TP, Egli M, McCullough AK, Lloyd RS
Structural basis for allosteric regulation of mycobacterial guanosine 5´-monophosphate reductase by ATP and GTP.
1. Nat Commun - published April 1, 2026
2. Doležal M, Knejzlík Z, Kouba T, Filimoněnko A, Šváchová H, Dedola M, Klíma M, Pichová I
Nuclear basket subunits Nup211 and Rsm1 influence RNA 3'-processing and transcription termination in fission yeast.
1. RNA - published April 1, 2026
2. Bednor L, Innokentev A, Sanchez AM, Sem A, Schwer B, Shuman S
Plant NLRs are getting into higher-order architectures.
1. Plant J - published April 1, 2026
2. Kim N, Chae E, Song JJ
A universal cis-proline lock defines catalysis in thioredoxin-fold enzymes.
1. Commun Biol - published April 1, 2026
2. Cunliffe T, Wang G, Penning S, Subedi P, Totsika M, Paxman JJ, Heras B
Targeting the Zika virus envelope domains I and III as a recombinant vaccine protects mice from lethal challenge.
1. NPJ Vaccines - published April 1, 2026
2. Dussupt V, Jensen JL, Rosado AP, Donofrio M, Pflugheber J, Mendez-Rivera L, Sankhala RS, Chen WH, Slike BM, Schmid A, Tran U, Metzger L, Peterson CE, Pinto AK, Vasan S, Collins ND, Farmer A, Michael NL, Joyce MG, Brien JD, Krebs SJ
Zanubrutinib and pirtobrutinib show synergistic killing and suppression of BTK signaling in MYD88-mutated lymphoma cells.
1. Blood Adv - published April 1, 2026
2. Pizzarella D, Kofides A, Hatcher JM, Liu X, Guijosa A, Tsakmaklis N, Peachey A, Wang J, Guerrera ML, Patterson CJ, Hunter ZR, Sun H, Sarosiek S, Castillo JJ, Buhrlage S, Dhe-Paganon S, Branagan AR, Treon SP, Liu S
Histone diversity in the archaeal domain of life.
1. Nat Commun - published April 1, 2026
2. Laursen SP, Luger K
Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes.
1. Nature - published April 1, 2026
2. Kılıç ZI, van Loenhout J, Chaillet M, van Es RM, Alcaraz PS, Vos HR, Noteborn WEM, Leung MR
B lymphocyte protein factories produced by hematopoietic stem cell gene editing.
1. Science - published April 1, 2026
2. Hartweger H, Ruprecht C, Yao KH, Laffont P, Lima Dos Reis G, Zhou P, Hägglöf T, Binet L, Loewe M, Hong JP, Xiao T, Sefik E, Hernandez B, Gazumyan A, Jankovic M, Seaman MS, Costa G, Nelson SA, Clark J, Kanatani S, Wilson PC, Krammer F, Levashina EA, Julien JP, Wardemann H, Sinnis P, Stamatatos L, Flavell RA, Nussenzweig MC
Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape.
1. Science - published April 1, 2026
2. Springstein BL, Javoor MG, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL, Schur FKM, Loose M
Activation mechanism of the full-length histidine kinase LvrB from pathogenic Leptospira.
1. Nat Commun - published April 1, 2026
2. Agustoni E, Mechaly A, Dalla Rizza J, Beriashvili D, Pluhackova K, Isaikina P, Trajtenberg F, Müntener T, Wunder EA Jr, Ko AI, Schirmer T, Buschiazzo A, Hiller S
Distinguishing cancer patients' mild and severe symptoms in radiotherapy via zero-shot and few-shot large language model-based probabilistic prompts.
1. BioData Min - published April 1, 2026
2. Chen MW, Yan Y, Shen X, Gao H, Chen Z
Cryo-EM structures of higher order Gephyrin oligomers reveal principles of inhibitory postsynaptic scaffold organization.
1. Nat Commun - published April 1, 2026
2. Ortiz-López D, Hove TT, Huhn C, Camuso S, van Gen Hassend PM, Sander B, Campbell BFN, Tyagarajan SK, Plückthun A, Specht CG, Maric HM, Böttcher B, Schindelin H
Gut Microbiota of Gray Snub-Nosed Monkeys: Adaptation to Seasonal Variations Through Energy Compensation and Thermogenesis.
1. Integr Zool - published April 1, 2026
2. Sun Y, Zhang M, Wang X, Huang X, Yu Y, Pan H, Li H, Shi L, Yang W, Zhang C, Ding B, Liu X, Li J, Qian C, Cheng B, Zhang C, Ran J, Li M
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis.
1. Nat Cell Biol - published April 1, 2026
2. Liu S, Gad M, Li C, Cho K, Liu Y, Wangdu K, Belay V, Millet A, Kojima H, Sanford H, Wölk M, Urnavicius L, Fedorova M, Patti GJ, Vinogradova EV, Hite RK, Birsoy K
Discovery of actinators, actin-derived bioactive peptides that modulate cytoskeleton and actin-related cellular activities.
1. Sci Adv - published April 1, 2026
2. Yi F, Guo J, Vo TT, Hetrick B, Haikerwal A, Zhou Z, Sealey L, He S, Han Y, Chilin L, Spear M, Yu D, Kim Y, Kashanchi F, Zhou T, Xu X, Lockhart C, Wu Y
Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.
1. Nucleic Acids Res - published April 1, 2026
2. Chickering T, Harp JM, Jiang Y, Qin J, He G, Hyde S, Ihlefeld A, Janas M, O'Flaherty DK, Schofield S, Szeto J, Theile CS, Charissé K, Jadhav V, Maier MA, Manoharan M, Egli M, Schlegel MK
Calcium dependent activation of the TMEM16F scramblase and ion channel.
1. Nat Struct Mol Biol - published April 1, 2026
2. Feng Z, Alvarenga OE, Di Zanni E, Lee S, Khelashvili G, Accardi A
A High-Throughput Fluorescence Polarization Assay for Screening Sirtuin Inhibitors.
1. ACS Chem Biol - published April 1, 2026
2. Peng K, Chakraborty S, Jin Y, Lin H
African Pan Genome Contigs Expose Biologically Relevant Sequence Still Hidden from Human Reference Frameworks.
1. bioRxiv - published April 1, 2026
2. Martini R, Tijjani A, Founta K, Cha D, Awai A, Maurice S, White JA, Mason CE, Cortes-Ciriano I, Robine N, Balogun O, Chambwe N, Davis MB
Structural determinants of endopilus assembly, stability and functional specificity in bacterial type II secretion.
1. bioRxiv - published April 1, 2026
2. Lejeune M, Ivashchenko S, Dazzoni R, Bardiaux B, Sonani RR, Vos M, Jacobsen T, Egelman EH, Nilges M, Francetic O, Shevchik VE, Izadi-Pruneyre N
Minor hemolysin-coregulated proteins (Hcp) form heteromeric complexes and mediate effector secretion in Bacteroidales type VI secretion systems.
1. J Biol Chem - published April 1, 2026
2. San-Miguel SG, Hillier JB, Saleh Al-Ammari MK, Johansson E, Kowalska A, Sauer U, Batista PR, Sandblad L, Uhlin BE, Cisneros DA
V-Sparse: From temporal-spatial visual semantic compression to coarse-to-fine interaction for text-video retrieval.
1. Neural Netw - published April 1, 2026
2. Liu X, Yin S, Wang J, Li W, Wang X, Zhu J, Shen Y, Yang YH
Capturing transient states of heterodimeric ABC transporter TM287/288 by Time-Resolved Small-Angle X-ray Scattering.
1. Biophys J - published April 1, 2026
2. Schröder L, De Vecchis D, Gruzinov A, Schäfer LV, Blanchet CE, Seeger MA, Tidow H, Josts I
Fine-Tuning a Transformer Model for METTL3 Lead Optimization.
1. ACS Bio Med Chem Au - published April 1, 2026
2. Matter CM, Caflisch A
Ligand-Induced Opening of a Cryptic Pocket in METTL14.
1. ACS Bio Med Chem Au - published April 1, 2026
2. Corbeski I, Bedi RK, Matter CM, Stamm F, Bochenkova E, Herok M, Hartshorn MJ, Caflisch A
Indirect inhibition of the NLRP3-interleukin-1β axis contributes to the efficacy of JAK1 inhibitors in experimental colitis and human ulcerative colitis.
1. Nat Commun - published April 1, 2026
2. Liu B, Spalinger MR, Invernizzi A, Gerdes E, Steglich B, Schwarzfischer M, Machicote A, Pelczar P, Pöhlmann D, Nawrocki M, Böttcher M, Aleko A, Velasquez LN, Wende S, Stallbaum F, Neuendorff J, Grosshauser S, Muscate F, Douilhet G, Perez LG, Sabihi M, Möller K, Viehweger F, Sutter JP, Kilian C, Kumar Y, Fründt T, Sauter G, Rösch T, Gagliani N, Caflisch A, Scharl M, Huber S
Structural Basis of Mitochondrial Transcription Regulation via Interactions of PolRMT and TFAM with Upstream Promoter DNA.
1. bioRxiv - published April 1, 2026
2. Shakey RE, Schroeder C, Deng X, Smith J, Hernandez AJ, Gao Y
Oropouche virus causes acute hepatitis in mice controlled by Type I interferons.
1. bioRxiv - published April 1, 2026
2. Sterling CE, Rush RE, McGaughey JJ, Snow BA, Benton AJ, Duprex WP, Amarasinghe GK, Monga SP, Hartman AL
A robust workflow for 3D imaging of human mitochondria using cryo-electron tomography.
1. bioRxiv - published April 1, 2026
2. Iragavarapu AG, Artemchuk O, Bobe D, Ratliff AC, Pavlov E, Aydin H
A High-throughput Fluorescence Polarization Assay for Screening Sirtuin Inhibitors.
1. bioRxiv - published April 1, 2026
2. Peng K, Chakraborty S, Jin Y, Lin H
Using Solution NMR to Characterize Biomolecular Condensates Under Biphasic Conditions.
1. J Vis Exp - published April 1, 2026
2. Novakovic M, Schmoll J, Emmanouilidis L, Allain FHT
Characteristics and Clinical Outcomes of BRCA Germline Mutation Carriers with Advanced Breast Cancer Treated with PARP (Poly ADP-Ribose Polymerase) Inhibitors: A Single-Institution Experience.
1. Cancers (Basel) - published April 1, 2026
2. Akkoc Mustafayev FN, Fountzilas E, Munsell MF, Layman RM, Yam C, Gutierrez AM, Albarracin CT, Ahmed Z, Schlacher K, Tainer JA, Arun BK
Genetic Diversity and Core Germplasm Development in Yunnan Tartary Buckwheat Based on Phenotypic and SNP Data.
1. Plants (Basel) - published April 1, 2026
2. Zhai B, Sun D, Huang C, Zhao Z, Xie J, Liu X, Lu W, Wang G, Wang L