Member Publications

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160 Member Publications for January 2025

Reliable and robust robotic handling of microplates via computer vision and touch feedback.
1. Front Robot AI - published January 23, 2025
2. Scamarcio V, Tan J, Stellacci F, Hughes J
Investigating Complexin-Membrane Interactions Using NMR and Optical Methods.
1. Methods Mol Biol - published January 13, 2025
2. Grasso EM, Eliezer D
TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids.
1. Cancer Immunol Res - published January 9, 2025
2. Sun Y, Maggs L, Panda A, Wright SJ, Cicerchia AM, Jenney A, Perricone MD, Mills CE, Cattaneo G, Ventin M, Chen F, Rasmussen MQ, Miranda A, Revach OY, Fang J, Fu A, Bowling PJ, Sharova T, Lawless A, Sorger PK, Bardeesy N, Wang X, Flaherty KT, Boland GM, Mehta A, Sade-Feldman M, Ferrone CR, Jenkins RW
Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan.
1. Skelet Muscle - published January 9, 2025
2. Hord JM, Burns S, Willer T, Goddeeris MM, Venzke D, Campbell KP
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands.
1. Mol Neurodegener - published January 9, 2025
2. Greven JA, Wydra JR, Greer RA, Zhi C, Price DA, Svoboda JD, Camitta CLM, Washington M, Leung DW, Song Y, Alexander-Brett J, Brett TJ
Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation.
1. Nat Commun - published January 9, 2025
2. Czyzyk D, Yan W, Messing S, Gillette W, Tsuji T, Yamaguchi M, Furuzono S, Turner DM, Esposito D, Nissley DV, McCormick F, Simanshu DK
DARPin-induced reactivation of p53 in HPV-positive cells.
1. Nat Struct Mol Biol - published January 9, 2025
2. Münick P, Strubel A, Balourdas DI, Funk JS, Mernberger M, Osterburg C, Dreier B, Schaefer JV, Tuppi M, Yüksel B, Schäfer B, Knapp S, Plückthun A, Stiewe T, Joerger AC, Dötsch V
RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation.
1. Nat Struct Mol Biol - published January 8, 2025
2. Brewer JJ, Inlow K, Mooney RA, Bosch B, Olinares PDB, Marcelino LP, Chait BT, Landick R, Gelles J, Campbell EA, Darst SA
An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.
1. Sci Transl Med - published January 8, 2025
2. Swanson OM, Zhang QE, Van Itallie E, Tian M, Brown AR, Harris C, Kapingidza AB, Rhodes B, Smith LM, Venkatayogi S, Cronin K, Frazier M, Parks R, Bar M, Jiang C, Martin Beem JS, Cheng HL, Davis J, McGovern K, Newman A, Edwards RJ, Cain D, Alam SM, Wiehe K, Saunders KO, Acharya P, Alt F, Haynes BF, Azoitei ML
Metagenomics reveals spatial variation in cyanobacterial composition, function, and biosynthetic potential in the Winam Gulf, Lake Victoria, Kenya.
1. Appl Environ Microbiol - published January 8, 2025
2. Hart LN, Zepernick BN, Natwora KE, Brown KM, Obuya JA, Lomeo D, Barnard MA, Okech EO, 2022-23 NSF-IRES Lake Victoria Research Consortium, Kiledal EA, Den Uyl PA, Olokotum M, Wilhelm SW, McKay RM, Drouillard KG, Sherman DH, Sitoki L, Achiya J, Getabu A, Otiso KM, Bullerjahn GS, Dick GJ
Structural basis for the transport and regulation mechanism of the multidrug resistance-associated protein 2.
1. Nat Commun - published January 8, 2025
2. Koide E, Pietz HL, Beltran J, Chen J
Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.
1. Elife - published January 8, 2025
2. Giese APJ, Weng WH, Kindt KS, Chang HHV, Montgomery JS, Ratzan EM, Beirl AJ, Aponte Rivera R, Lotthammer JM, Walujkar S, Foster MP, Zobeiri OA, Holt JR, Riazuddin S, Cullen KE, Sotomayor M, Ahmed ZM
DJK-5, an anti-biofilm peptide, increases Staphylococcus aureus sensitivity to colistin killing in co-biofilms with Pseudomonas aeruginosa.
1. NPJ Biofilms Microbiomes - published January 8, 2025
2. Wardell SJT, Yung DBY, Gupta A, Bostina M, Overhage J, Hancock REW, Pletzer D
Formation of I(2)+III(2) supercomplex rescues respiratory chain defects.
1. Cell Metab - published January 8, 2025
2. Liang C, Padavannil A, Zhang S, Beh S, Robinson DRL, Meisterknecht J, Cabrera-Orefice A, Koves TR, Watanabe C, Watanabe M, Illescas M, Lim R, Johnson JM, Ren S, Wu YJ, Kappei D, Ghelli AM, Funai K, Osaka H, Muoio D, Ugalde C, Wittig I, Stroud DA, Letts JA, Ho L
Substrate adaptors are flexible tethering modules that enhance substrate methylation by the arginine methyltransferase PRMT5.
1. J Biol Chem - published January 8, 2025
2. Jin CY, Hunkeler M, Mulvaney KM, Sellers WR, Fischer ES
Single-molecule analysis of PARP1-G-quadruplex interaction.
1. bioRxiv - published January 8, 2025
2. Gaur P, Bain FE, Meah R, Spies M
Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease.
1. Viruses - published January 8, 2025
2. Azzolino VN, Shaqra AM, Ali A, Kurt Yilmaz N, Schiffer CA
Higher-order transient structures and the principle of dynamic connectivity in membrane signaling.
1. Proc Natl Acad Sci U S A - published January 7, 2025
2. Zhang Y, MacKinnon R
DNA targeting by compact Cas9d and its resurrected ancestor.
1. Nat Commun - published January 7, 2025
2. Ocampo RF, Bravo JPK, Dangerfield TL, Nocedal I, Jirde SA, Alexander LM, Thomas NC, Das A, Nielson S, Johnson KA, Brown CT, Butterfield CN, Goltsman DSA, Taylor DW
Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications.
1. Nat Struct Mol Biol - published January 7, 2025
2. Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice.
1. Nat Commun - published January 7, 2025
2. Halfmann PJ, Patel RS, Loeffler K, Yasuhara A, Van De Velde LA, Yang JE, Chervin J, Troxell C, Huang M, Zheng N, Wright ER, Thomas PG, Wilson PC, Kawaoka Y, Kane RS
Single-molecule analysis reveals that IPMK enhances the DNA-binding activity of the transcription factor SRF.
1. Nucleic Acids Res - published January 7, 2025
2. Ahn H, Yu J, Ryu K, Ryu J, Kim S, Park JY, Kim JK, Jung I, An H, Hong S, Kim E, Park K, Ahn M, Min S, Jung I, Lee D, Lee T, Byun Y, Song JJ, Kim J, Cho WK, Lee G, Kim S
Mechanism-guided engineering of a minimal biological particle for genome editing.
1. Proc Natl Acad Sci U S A - published January 7, 2025
2. Ngo W, Peukes J, Baldwin A, Xue ZW, Hwang S, Stickels RR, Lin Z, Satpathy AT, Wells JA, Schekman R, Nogales E, Doudna JA
Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus.
1. J Cell Biol - published January 6, 2025
2. Fung HYJ, Jiou J, Niesman AB, Bernardes NE, Chook YM
Artificial Metalloenzymes with Two Catalytic Cofactors for Tandem Abiotic Transformations.
1. Angew Chem Int Ed Engl - published January 6, 2025
2. Wang W, Tachibana R, Zhang K, Lau K, Pojer F, Ward TR, Hu X
Replacement of a single residue changes the primary specificity of thrombin.
1. Fertil Steril - published January 6, 2025
2. Rossi AD, Deavila S, Mohammed BM, Korolev S, Di Cera E
Alcohol and substance use differentially impact suicidal ideation in a longitudinal cohort of bipolar disorder.
1. Psychiatry Res - published January 6, 2025
2. Smith JL, McInnis MG, Sperry SH
Structure-guided insights into TIR-mediated bacterial and eukaryotic immunity.
1. Structure - published January 6, 2025
2. Chakravarti A, Patel DJ
Long-Term Protein Synthesis with PURE in a Mesoscale Dialysis System.
1. ACS Synth Biol - published January 5, 2025
2. Roset Julià L, Grasemann L, Stellacci F, Maerkl SJ
RosettaHDX: Predicting antibody-antigen interaction from hydrogen-deuterium exchange mass spectrometry data.
1. J Struct Biol - published January 5, 2025
2. Tran MH, Martina CE, Moretti R, Nagel M, Schey KL, Meiler J
Elevated Levels of Serum Alpha-2-Macroglobulin Associate with Diabetes Status and Incident Cardiovascular Disease in Type 1 Diabetes.
1. J Lipid Res - published January 4, 2025
2. Shao B, Snell-Bergeon JK, de Boer IH, Davidson WS, Bornfeldt KE, Heinecke JW
Cross-modal sensory compensation increases mosquito attraction to humans.
1. Sci Adv - published January 3, 2025
2. Morita T, Lyn NG, von Heynitz RK, Goldman OV, Sorrells TR, DeGennaro M, Matthews BJ, Houri-Zeevi L, Vosshall LB
The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes.
1. EMBO J - published January 3, 2025
2. Melnikov N, Junglas B, Halbi G, Nachmias D, Zerbib E, Gueta N, Upcher A, Zalk R, Sachse C, Bernheim-Groswasser A, Elia N
A risk-based approach can guide safe cell line development and cell banking for scaled-up cultivated meat production.
1. Nat Food - published January 3, 2025
2. Bennie RZ, Ogilvie OJ, Loo LSW, Zhou H, Ng SK, Jin A, Trlin HJF, Wan A, Yu H, Domigan LJ, Dobson RCJ
Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity.
1. Nat Cell Biol - published January 3, 2025
2. Latorre-Muro P, Vitale T, Ravichandran M, Zhang K, Palozzi JM, Bennett CF, Lamas-Paz A, Sohn JH, Jackson TD, Jedrychowski M, Gygi SP, Kajimura S, Schmoker A, Jeon H, Eck MJ, Puigserver P
The impact of library size and scale of testing on virtual screening.
1. Nat Chem Biol - published January 3, 2025
2. Liu F, Mailhot O, Glenn IS, Vigneron SF, Bassim V, Xu X, Fonseca-Valencia K, Smith MS, Radchenko DS, Fraser JS, Moroz YS, Irwin JJ, Shoichet BK
A bipartite bacterial virulence factor targets the complement system and neutrophil activation.
1. EMBO J - published January 3, 2025
2. Kurniyati K, Clark ND, Wang H, Deng Y, Sze CW, Visser MB, Malkowski MG, Li C
Replacement of a single residue changes the primary specificity of thrombin.
1. J Thromb Haemost - published January 3, 2025
2. Rossi AD, Deavila S, Mohammed BM, Korolev S, Di Cera E
Cross-reactive sarbecovirus antibodies induced by mosaic RBD-nanoparticles.
1. bioRxiv - published January 3, 2025
2. Fan C, Keeffe JR, Malecek KE, Cohen AA, West AP Jr, Baharani VA, Rorick AV, Gao H, Gnanapragasam PNP, Rho S, Alvarez J, Segovia LN, Hatziioannou T, Bieniasz PD, Bjorkman PJ
Dental Pulp Stem Cells Attenuate Early Brain Injury After Subarachnoid Hemorrhage via miR-26a-5p/PTEN/AKT Pathway.
1. Neurochem Res - published January 3, 2025
2. He P, Zhang H, Wang J, Guo Y, Tian Q, Liu C, Gong P, Ye Q, Peng Y, Li M
Catching carbon fixation without fixing.
1. Science - published January 3, 2025
2. Feng X, Rees DC
Mechanisms of uropathogenic E. coli mucosal association in the gastrointestinal tract.
1. Sci Adv - published January 3, 2025
2. Azimzadeh PN, Birchenough GM, Gualbuerto NC, Pinkner JS, Tamadonfar KO, Beatty W, Hannan TJ, Dodson KW, Ibarra EC, Kim S, Schreiber HL 4th, Janetka JW, Kau AL, Earl AM, Miller MJ, Hansson GC, Hultgren SJ
Room temperature CRISPR diagnostics for low-resource settings.
1. Sci Rep - published January 3, 2025
2. Nalefski EA, Sinan S, Cantera JL, Kim AG, Kooistra RM, Rivera RE, Janshen JP, Bhadra S, Bishop JD, Ellington AD, Finklestein IJ, Madan D
Antibody-secreting cell repertoires hold high-affinity anti-rocuronium specificities that can induce anaphylaxis in vivo.
1. J Allergy Clin Immunol - published January 3, 2025
2. Dejoux A, Zhu Q, Woolfe A, Godon O, Ellouze S, Mottet G, Castrillon C, Gillis C, Pecalvel C, Ganneau C, Iannascoli B, Lemoine F, Saul F, England P, Reber LL, Gouel-Chéron A, de Chaisemartin L, Haouz A, Millot GA, Bay S, Gérard A, Jönsson F, Chollet-Martin S, Bruhns P
Purification and characterization of full-length monomeric TEC family kinase, ITK.
1. Protein Expr Purif - published January 3, 2025
2. Rathnayake UM, Wada J, Wall VE, Jones J, Jenkins LM, Andreotti AH, Samelson LE
CryoVIA: An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs.
1. Structure - published January 3, 2025
2. Schönnenbeck P, Junglas B, Sachse C
Identification and optimization of a small molecule inhibitor of the ovarian tumor protease of the Crimean-Congo hemorrhagic fever virus.
1. Bioorg Med Chem - published January 3, 2025
2. Beckmann L, Liessmann F, Icker M, Rieger D, Schlegel P, Urban N, Schaefer M, Meiler J, Schoeder CT, Tretbar M
HBV DNA integration and somatic mutations in HCC patients with HBV-HCV dual infection reveals profiles intermediate between HBV- and HCV-related HCC.
1. J Biomed Sci - published January 2, 2025
2. Li CL, Hsu CL, Lin YY, Ho MC, Hu RH, Tzeng ST, Wang YC, Tanaka Y, Chen PJ, Yeh SH
Discovery of High-Affinity SMARCA2/4 Bromodomain Ligands and Development of Potent and Exceptionally Selective SMARCA2 PROTAC Degraders.
1. J Med Chem - published January 2, 2025
2. Leng L, Tu W, Yang L, Huang L, Wang M, Meagher JL, Chinnaswamy K, Allu SR, Rej RK, Tošović J, Harikrishnan L, Li Z, Sui Z, Stuckey JA, Wang S
Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase.
1. Nat Commun - published January 2, 2025
2. Roberts JR, Horibata Y, Kwarcinski FE, Lam V, Raczkowski AM, Hubbard A, White B, Sugimoto H, Tall GG, Ohi MD, Maeda S
The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling.
1. Elife - published January 2, 2025
2. Bruguera ES, Mahoney JP, Weis WI
Discovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers.
1. J Med Chem - published January 2, 2025
2. Yang L, Tu W, Leng L, Huang L, Jiang W, Wang M, Wang Y, Meagher JL, Chinnaswamy K, Stuckey JA, Wang M, Wen B, Sun D, Harikrishnan L, Strickland C, Rice C, Orth P, Sui Z, Wang S
Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy.
1. Sci Rep - published January 2, 2025
2. Schnicker NJ, Xu Z, Amir M, Gakhar L, Huang CL
The Future Hospital in Global Health Systems: The Future Hospital as an Entity.
1. Int J Health Plann Manage - published January 2, 2025
2. Nj S, A A, L A, L C, A C, M G, M G, F M, Y N, Onoka C, McKee M
Rational engineering of minimally immunogenic nucleases for gene therapy.
1. Nat Commun - published January 2, 2025
2. Raghavan R, Friedrich MJ, King I, Chau-Duy-Tam Vo S, Strebinger D, Lash B, Kilian M, Platten M, Macrae RK, Song Y, Nivon L, Zhang F
MCTS2 and distinct eIF2D roles in uORF-dependent translation regulation revealed by in vitro re-initiation assays.
1. EMBO J - published January 2, 2025
2. Meurs R, De Matos M, Bothe A, Guex N, Weber T, Teleman AA, Ban N, Gatfield D
A divergent two-domain structure of the anti-Müllerian hormone prodomain.
1. Proc Natl Acad Sci U S A - published January 2, 2025
2. Howard JA, Hok L, Cate RL, Sanford NJ, Hart KN, Leach EAE, Bruening AS, Nagykery N, Donahoe PK, Pépin D, Thompson TB
Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases.
1. bioRxiv - published January 2, 2025
2. Finney J, Kuraoka M, Song S, Watanabe A, Liang X, Liao D, Moody MA, Walter EB, Harrison SC, Kelsoe G
Structure of an LGR dimer - an evolutionary predecessor of glycoprotein hormone receptors.
1. bioRxiv - published January 2, 2025
2. Gong Z, Chen S, Fu Z, Kloss B, Wang C, Clarke OB, Fan QR, Hendrickson WA
Towards Improved Peptidic α-Ketoamide Inhibitors of the Plasmodial Subtilisin-Like SUB1: Exploration of N-Terminal Extensions and Cyclic Constraints.
1. ChemMedChem - published January 2, 2025
2. Puszko AK, Batista FA, Ejjoummany A, Bouillon A, Maurel M, Adler P, Legru A, Martinez M, Ortega Varga L, Hadjadj M, Alzari PM, Blondel A, Haouz A, Barale JC, Hernandez JF
FhaA plays a key role in mycobacterial polar elongation and asymmetric growth.
1. mBio - published January 2, 2025
2. Rossello J, Rivera B, Anzibar Fialho M, Augusto I, Gil M, Forrellad MA, Bigi F, Rodríguez Taño A, Urdániz E, Piuri M, Miranda K, Wehenkel AM, Alzari PM, Malacrida L, Durán R
Scaffold-enabled high-resolution cryo-EM structure determination of RNA.
1. Nat Commun - published January 2, 2025
2. Haack DB, Rudolfs B, Jin S, Khitun A, Weeks KM, Toor N
NuFold: end-to-end approach for RNA tertiary structure prediction with flexible nucleobase center representation.
1. Nat Commun - published January 2, 2025
2. Kagaya Y, Zhang Z, Ibtehaz N, Wang X, Nakamura T, Punuru PD, Kihara D
Functional classification of tauopathy strains reveals the role of protofilament core residues.
1. Sci Adv - published January 2, 2025
2. Vaquer-Alicea J, Manon VA, Bommareddy V, Kunach P, Gupta A, Monistrol J, Perez VA, Tran HT, Saez-Calveras N, Du S, Batra S, Stoddard D, White CL 3rd, Joachimiak LA, Shahmoradian SH, Diamond MI
Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST.
1. Sci Adv - published January 2, 2025
2. Kraus F, He Y, Swarup S, Overmyer KA, Jiang Y, Brenner J, Capitanio C, Bieber A, Jen A, Nightingale NM, Anderson BJ, Lee C, Paulo JA, Smith IR, Plitzko JM, Gygi SP, Schulman BA, Wilfling F, Coon JJ, Harper JW
Antigen 43 associated with Escherichia coli membrane vesicles contributes to bacterial cell association and biofilm formation.
1. Microbiol Spectr - published January 2, 2025
2. Zavan L, Hor L, Johnston EL, Paxman J, Heras B, Kaparakis-Liaskos M
Oncogenic mutant KRAS inhibition through oxidation at cysteine 118.
1. Mol Oncol - published January 2, 2025
2. Kramer-Drauberg M, Petrini E, Mira A, Patrucco E, Scardaci R, Savinelli I, Wang H, Qiao K, Carrà G, Nokin MJ, Zhou Z, Westover KD, Santamaria D, Porporato PE, Ambrogio C
Resolving native GABA(A) receptor structures from the human brain.
1. Nature - published January 2, 2025
2. Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Aminocholestane and Aminoandrostane Inhibitors of the SH2 Domain-Containing Inositol 5'-Phosphatase (SHIP).
1. ChemMedChem - published January 2, 2025
2. Pacherille AM, Viernes DR, Pedicone C, Fernandes S, Dungan OM, Dormann S, Wallach DR, Sudan R, Brooks R, Russo CM, Howard KT, Cosgrove MS, Kerr WG, Chisholm JD
The molecular basis of Human FN3K mediated phosphorylation of glycated substrates.
1. Nat Commun - published January 2, 2025
2. Garg A, On KF, Xiao Y, Elkayam E, Cifani P, David Y, Joshua-Tor L
Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq.
1. Nat Commun - published January 2, 2025
2. Forino NM, Woo JZ, Zaug AJ, Jimenez AG, Edelson E, Cech TR, Rouskin S, Stone MD
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus.
1. Mucosal Immunol - published January 2, 2025
2. Langel SN, Otero CE, Steppe JT, Williams CA, Travieso T, Chang J, Webster H, Williamson LE, Crowe JE Jr, Greenberg HB, Wu H, Hornik CP, Mansouri K, Edwards RJ, Stalls V, Acharya P, Blasi M, Permar SR
KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid.
1. Nat Microbiol - published January 2, 2025
2. McLean TC, Balaguer-Pérez F, Chandanani J, Thomas CM, Aicart-Ramos C, Burick S, Olinares PDB, Gobbato G, Mundy JEA, Chait BT, Lawson DM, Darst SA, Campbell EA, Moreno-Herrero F, Le TBK
Glutamine Synthetase: Diverse Regulation and Functions of an Ancient Enzyme.
1. Biochemistry - published January 2, 2025
2. Tecson MCB, Geluz C, Cruz Y, Greene ER
Another cryo-EM success: structure of FXIII.
1. Blood - published January 2, 2025
2. Di Cera E
A method for facile production of variable lymphocyte receptors using SHuffle Escherichia coli.
1. Biotechnol Prog - published January 2, 2025
2. Appelt EA, Thoden JB, Dancy C, Bachmeier HD, Gehrke SA, Staffenson MA, Rayment I, Katt ME, Holden HM, Shusta EV
Human naïve B cells recognize prepandemic influenza virus hemagglutinins.
1. Sci Immunol - published January 2, 2025
2. Feldman J, Ramos ASF, Vu M, Maurer DP, Rosado VC, Lingwood D, Bajic G, Schmidt AG
Structure-guided discovery of viral proteins that inhibit host immunity.
1. Cell - published January 2, 2025
2. Yirmiya E, Hobbs SJ, Leavitt A, Osterman I, Avraham C, Hochhauser D, Madhala B, Skovorodka M, Tan JMJ, Toyoda HC, Chebotar I, Itkin M, Malitsky S, Amitai G, Kranzusch PJ, Sorek R
Recombinant Antibodies Inhibit Enzymatic Activity of the E3 Ubiquitin Ligase CHIP via Multiple Mechanisms.
1. J Biol Chem - published January 2, 2025
2. Chung DH, Connelly EJ, Unnikrishnan A, Chuo SW, Wucherer K, Nadel CM, Gestwicki JE, Southworth DR, Craik CS
Antiviral activity of tecovirimat against monkeypox virus clades 1a, 1b, 2a, and 2b.
1. Lancet Infect Dis - published January 2, 2025
2. Postal J, Guivel-Benhassine F, Porrot F, Grassin Q, Crook JM, Vernuccio R, Caro V, Vanhomwegen J, Guardado-Calvo P, Simon-Lorière E, Dacheux L, Manuguerra JC, Schwartz O
Genome-wide profiling of tRNA modifications by Induro-tRNAseq reveals coordinated changes.
1. Nat Commun - published January 2, 2025
2. Nakano Y, Gamper H, McGuigan H, Maharjan S, Li J, Sun Z, Yigit E, Grünberg S, Krishnan K, Li NS, Piccirilli JA, Kleiner R, Nichols N, Gregory BD, Hou YM
AI-based methods for biomolecular structure modeling for Cryo-EM.
1. Curr Opin Struct Biol - published January 2, 2025
2. Farheen F, Terashi G, Zhu H, Kihara D
Cost-effective production of meaty aroma from porcine cells for hybrid cultivated meat.
1. Food Chem - published January 2, 2025
2. Zhou H, Loo LSW, Ong FYT, Lou X, Wang J, Myint MK, Thong A, Seow DCS, Wibowo M, Ng S, Lv Y, Kwang LG, Bennie RZ, Pang KT, Dobson RCJ, Domigan LJ, Kanagasundaram Y, Yu H
Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium.
1. Alzheimers Dement - published January 2, 2025
2. Elyaman W, Stern LJ, Jiang N, Dressman D, Bradley P, Klatzmann D, Bradshaw EM, Farber DL, Kent SC, Chizari S, Funk K, Devanand D, Thakur KT, Raj T, Dalahmah OA, Sarkis RA, Weiner HL, Shneider NA, Przedborski S
Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex.
1. Nat Commun - published January 2, 2025
2. Bi M, Wang X, Wang J, Xu J, Sun W, Adediwura VA, Miao Y, Cheng Y, Ye L
Isolation of PCSK9-specific nanobodies from synthetic libraries using a combined protein selection strategy.
1. Sci Rep - published January 2, 2025
2. Thaiprayoon A, Chantarasorn Y, Oonanant W, Kasorn A, Longsompurana P, Tapaneeyakorn S, Riangrungroj P, Loison F, Kruse AC, DeLisa MP, Waraho-Zhmayev D
Development of Potent and Selective CK1α Molecular Glue Degraders.
1. J Med Chem - published January 2, 2025
2. Geng Q, Jiang Z, Byun WS, Donovan KA, Zhuang Z, Jiang F, Jones HM, Razumkov H, Tang MT, Sarott RC, Fischer ES, Corsello SM, Hinshaw SM, Gray NS
Analysis of TEM micrographs with deep learning reveals APOE genotype-specific associations between HDL particle diameter and Alzheimer's dementia.
1. Cell Rep Methods - published January 2, 2025
2. Zheng JJ, Hong BV, Agus JK, Tang X, Guo F, Lebrilla CB, Maezawa I, Jin LW, Vreeland WN, Ripple DC, Zivkovic AM
Anisotropic hydrogel microelectrodes for intraspinal neural recordings in vivo.
1. Nat Commun - published January 2, 2025
2. Huang S, Xiao R, Lin S, Wu Z, Lin C, Jang G, Hong E, Gupta S, Lu F, Chen B, Liu X, Sahasrabudhe A, Zhang Z, He Z, Crosby AJ, Sumaria K, Liu T, Wang Q, Rao S
Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing.
1. PLoS Pathog - published January 2, 2025
2. Scott TM, Arnold LM, Powers JA, McCann DA, Rowe AB, Christensen DE, Pereira MJ, Zhou W, Torrez RM, Iwasa JH, Kranzusch PJ, Sundquist WI, Johnson JS
Editorial Expression of Concern: 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.
1. Nature - published January 2, 2025
2. Fradet-Turcotte A, Canny MD, Escribano-Díaz C, Orthwein A, Leung CCY, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F, Durocher D
Molecular basis of vitamin K driven γ-carboxylation at membrane interface.
1. Nature - published January 2, 2025
2. Cao Q, Ammerman A, Saimi M, Lin Z, Shen G, Chen H, Sun J, Chai M, Liu S, Hsu FF, Krezel AM, Gross ML, Xu J, Garcia BA, Liu B, Li W
Projection-targeted photopharmacology reveals distinct anxiolytic roles for presynaptic mGluR2 in prefrontal- and insula-amygdala synapses.
1. Neuron - published January 2, 2025
2. Munguba H, Srivastava I, Gutzeit VA, Singh A, Vijay A, Kristt M, Arefin A, Thukral S, Broichhagen J, Stujenske JM, Liston C, Levitz J
The mycobacterial ABC transporter IrtAB employs a membrane-facing crevice for siderophore-mediated iron uptake.
1. Nat Commun - published January 2, 2025
2. Gonda I, Sorrentino S, Galazzo L, Lichti NP, Arnold FM, Mehdipour AR, Bordignon E, Seeger MA
Structural analysis of extracellular ATP-independent chaperones of streptococcal species and protein substrate interactions.
1. mSphere - published January 2, 2025
2. Agbavor C, Torres M, Inniss NL, Latimer S, Minasov G, Shuvalova L, Wawrzak Z, Borek D, Otwinowski Z, Stogios PJ, Savchenko A, Anderson WF, Satchell KJF, Cahoon LA
Proteomic Analysis of Unicellular Cyanobacterium Crocosphaera subtropica ATCC 51142 under Extended Light or Dark Growth.
1. J Proteome Res - published January 2, 2025
2. Panda P, Giri SJ, Sherman LA, Kihara D, Aryal UK
Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase.
1. Mol Cell - published January 2, 2025
2. Carrillo Roas S, Yagita Y, Murphy P, Kurzbauer R, Clausen T, Zavodszky E, Hegde RS
C-terminal amides mark proteins for degradation via SCF-FBXO31.
1. Nature - published January 2, 2025
2. Muhar MF, Farnung J, Cernakova M, Hofmann R, Henneberg LT, Pfleiderer MM, Denoth-Lippuner A, Kalčic F, Nievergelt AS, Peters Al-Bayati M, Sidiropoulos ND, Beier V, Mann M, Jessberger S, Jinek M, Schulman BA, Bode JW, Corn JE
CARD domains mediate anti-phage defence in bacterial gasdermin systems.
1. Nature - published January 2, 2025
2. Wein T, Millman A, Lange K, Yirmiya E, Hadary R, Garb J, Melamed S, Amitai G, Dym O, Steinruecke F, Hill AB, Kranzusch PJ, Sorek R
Cryo-EM structure of AAV2 Rep68 bound to integration site AAVS1: insights into the mechanism of DNA melting.
1. Nucleic Acids Res - published January 2, 2025
2. Jaiswal R, Braud B, Hernandez-Ramirez KC, Santosh V, Washington A, Escalante CR
Optimization of Structure-guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS-CoV-2.
1. Angew Chem Int Ed Engl - published January 2, 2025
2. Schwalbe H, Ceylan B, Adam J, Toews S, Kaiser F, Doerr J, Scheppa D, Tants JN, Smart A, Schoth J, Philipp S, Stirnal E, Ferner J, Richter C, Sreeramulu S, Caliskan N, Schlundt A, Weigand JE, Göbel M, Wacker A
A PARP2 active site helix melts to permit DNA damage-induced enzymatic activation.
1. Mol Cell - published January 2, 2025
2. Smith-Pillet ES, Billur R, Langelier MF, Talele TT, Pascal JM, Black BE
rcsb-api: Python Toolkit for Streamlining Access to RCSB Protein Data Bank APIs.
1. J Mol Biol - published January 2, 2025
2. Piehl DW, Vallat B, Truong I, Morsy H, Bhatt R, Blaumann S, Biswas P, Rose Y, Bittrich S, Duarte JM, Segura J, Bi C, Myers-Turnbull D, Hudson BP, Zardecki C, Burley SK
Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models.
1. Environ Int - published January 2, 2025
2. Bj W, S K, L D, Ka AN, M M, C T, E G, Am C, M O, Dj J, O A, Ag L, Dj R, Ea BK, P FL, Am M, R H, Ba C, Kp A
Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis.
1. bioRxiv - published January 2, 2025
2. Shimogawa M, Li MH, Park GSH, Ramirez J, Lee H, Watson PR, Sharma S, Lin Z, Peng C, Garcia BA, Christianson DW, Rhoades E, Eliezer D, Petersson EJ
Kiwa is a bacterial membrane-embedded defence supercomplex activated by phage-induced membrane changes.
1. bioRxiv - published January 2, 2025
2. Zhang Z, Todeschini TC, Wu Y, Kogay R, Naji A, Rodriguez JC, Mondi R, Kaganovich D, Taylor DW, Bravo JPK, Teplova M, Amen T, Koonin EV, Patel DJ, Nobrega FL
Complex Water Networks Visualized through 2.2-2.3 Å Cryogenic Electron Microscopy of RNA.
1. bioRxiv - published January 2, 2025
2. Kretsch RC, Li S, Pintilie G, Palo MZ, Case DA, Das R, Zhang K, Chiu W
Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350.
1. Immunity - published January 2, 2025
2. Joyce MG, Bu W, Chen WH, Gillespie RA, Andrews SF, Wheatley AK, Tsybovsky Y, Jensen JL, Stephens T, Prabhakaran M, Fisher BE, Narpala SR, Bagchi M, McDermott AB, Nabel GJ, Kwong PD, Mascola JR, Cohen JI, Kanekiyo M
Context-specific inhibition of mitochondrial ribosomes by phenicol and oxazolidinone antibiotics.
1. Nucleic Acids Res - published January 2, 2025
2. Bibel B, Raskar T, Couvillion M, Lee M, Kleinman JI, Takeuchi-Tomita N, Churchman LS, Fraser JS, Fujimori DG
Large serine integrases utilise scavenged phage proteins as directionality cofactors.
1. Nucleic Acids Res - published January 2, 2025
2. Alsaleh A, Holland A, Shin H, Reyes TP, Baksh A, Taiwo-Aiyerin OT, Pigli Y, Rice PA, Olorunniji FJ
Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast.
1. bioRxiv - published January 1, 2025
2. Benning FMC, Bell TA, Nguyen TH, Syau D, Connell LB, Coughlin M, Nordstrom AEH, Ericsson M, daCosta CJB, Chao LH
Structure of Plasmodium vivaxN-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy.
1. Acta Crystallogr F Struct Biol Commun - published January 1, 2025
2. Mendez A, Bolling C, Taylor S, Makumire S, Staker B, Reers A, Hammerson B, Mayclin SJ, Abendroth J, Lorimer DD, Edwards TE, Tate EW, Subramanian S, Bell AS, Myler PJ, Asojo OA, Chakafana G
Loss of Cdkn1a protects against MASLD alone or with alcohol intake by preserving lipid homeostasis.
1. JHEP Rep - published January 1, 2025
2. Lamas-Paz A, Hionides-Gutiérrez A, Guo F, Jorquera G, Morán-Blanco L, Benedé-Ubieto R, Mesquita M, Estévez-Vázquez O, Zheng K, Mazariegos M, Vázquez-Ogando E, Blázquez-López E, Asensio I, Mutlu B, Gomez-Santos B, Peligros MI, Vaquero J, Bañares R, Delgado TC, Martínez-Chantar ML, Martínez-Naves E, Sanz-García C, Mohamed MR, Tesolato S, Iniesta P, Gallego-Durán R, Maya-Miles D, Ampuero J, Romero-Gómez M, Martínez-Alcocer A, Sanfeliu-Redondo D, Fernández-Iglesias A, Gracia-Sancho J, Coll M, Graupera I, Ginès P, Ciudin A, Rivera-Esteban J, Pericàs JM, Ávila MA, Frutos MD, Martínez-Cáceres CM, Ramos-Molina B, Aspichueta P, Puigserver P, Nevzorova YA, Cubero FJ
Structural dynamics and binding of Caenorhabditis elegans lifespan-extending lipid binding protein-3 to polyunsaturated fatty acids.
1. Protein Sci - published January 1, 2025
2. Cuevas AR, Tillman MC, Wang MC, Ortlund EA
Alterations in Cellular Gene Expression Due to Co-Infection With Kaposi's Sarcoma-Associated Herpesvirus and SARS-CoV-2: Implications for Disease Severity.
1. J Med Virol - published January 1, 2025
2. Chen J, Fan J, Malaviarachchi PA, Post SR, Lin Z, Zhang X, Qin Z
Vaccination with different group 2 influenza subtypes alters epitope targeting and breadth of hemagglutinin stem-specific human B cells.
1. Sci Transl Med - published January 1, 2025
2. Mantus GE, Chopde AJ, Gorman J, Cominsky LY, Ourahmane A, Creanga A, Shimberg GD, Gillespie RA, Van Wazer DJ, Zhou T, Gajjala SR, Williams C, Maestle E, Reed DS, Serebryannyy L, Costner P, Holman L, Casazza JP, Koup RA, Dropulic LK, Kwong PD, McDermott AB, Kanekiyo M, Andrews SF
Structural diversity of axonemes across mammalian motile cilia.
1. Nature - published January 1, 2025
2. Leung MR, Sun C, Zeng J, Anderson JR, Niu Q, Huang W, Noteborn WEM, Brown A, Zeev-Ben-Mordehai T, Zhang R
Structural basis for TIR domain-mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM.
1. Proc Natl Acad Sci U S A - published January 1, 2025
2. Manik MK, Pan M, Xiao L, Gu W, Kim H, Pospich S, Hedger A, Vajjhala PR, Lee MYL, Qian X, Landsberg MJ, Ve T, Nanson JD, Raunser S, Stacey KJ, Wu H, Kobe B
Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication.
1. Nat Commun - published January 1, 2025
2. Lee D, Koo B, Kim S, Byun J, Hong J, Shin DY, Sun CH, Kim J, Song JJ, Jaiswal S, Yoon SS, Kim S, Koh Y
Accessing ultrastable glass via a bulk transformation.
1. Nat Commun - published January 1, 2025
2. Bu H, Luan H, Kang J, Jia J, Guo W, Su Y, Ding H, Chang HS, Wang R, Wu Y, Shi L, Gong P, Zeng Q, Shao Y, Yao K
The UBR domain of plant Ubr1 homolog PRT6 accommodates basic and hydrophobic amino termini for substrate recognition.
1. J Mol Biol - published January 1, 2025
2. Rudi O, Hodakova Z, Saad CF, Winter N, Grishkovskaya I, Böhm J, Jarck G, Schleiffer A, Haselbach D, Bachmair A
Dual-Cys bacteriophytochromes: intermediates in cyanobacterial phytochrome evolution?
1. FEBS J - published January 1, 2025
2. Yang HW, Song JY, Song JJ, Kim YW, Rockwell NC, Kim W, Kim H, Lagarias JC, Park YI
Interpretable Deep-Learning pK(a) Prediction for Small Molecule Drugs via Atomic Sensitivity Analysis.
1. J Chem Inf Model - published January 1, 2025
2. DeCorte J, Brown B, Jeffrey R, Meiler J
NADH-bound AIF activates the mitochondrial CHCHD4/MIA40 chaperone by a substrate-mimicry mechanism.
1. EMBO J - published January 1, 2025
2. Brosey CA, Shen R, Tainer JA
Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis.
1. Nat Commun - published January 1, 2025
2. Cicuéndez B, Mora A, López JA, Curtabbi A, Pérez-García J, Porteiro B, Jimenez-Blasco D, Latorre-Muro P, Vo P, Jerome M, Gómez-Santos B, Romero-Becerra R, Leiva M, Rodríguez E, León M, Leiva-Vega L, Gómez-Lado N, Torres JL, Hernández-Cosido L, Aguiar P, Marcos M, Jastroch M, Daiber A, Aspichueta P, Bolaños JP, Spinelli JB, Puigserver P, Enriquez JA, Vázquez J, Folgueira C, Sabio G
Structural determinants of peanut induced anaphylaxis.
1. J Allergy Clin Immunol - published January 1, 2025
2. Smith SA, Shrem RA, Lança BBC, Zhang J, Wong JJW, Croote D, Peebles RS Jr, Spiller BW
Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13.
1. Nat Commun - published January 1, 2025
2. Cheng SJ, Gafaar T, Kuttiyatveetil JRA, Sverzhinsky A, Chen C, Xu M, Lilley A, Pascal JM, Leung AKL
Structural basis of directionality control in large serine integrases.
1. bioRxiv - published January 1, 2025
2. Shin H, Pigli Y, Reyes TP, Fuller JR, Olorunniji FJ, Rice PA
Context-Dependent Heterotypic Assemblies of Intrinsically Disordered Peptides.
1. J Am Chem Soc - published January 1, 2025
2. Qiao Y, Zia A, Wu G, Liu Z, Guo J, Chu M, He H, Wang F, Xu B
Discovery of non-retinoid compounds that suppress the pathogenic effects of misfolded rhodopsin in a mouse model of retinitis pigmentosa.
1. PLoS Biol - published January 1, 2025
2. Ortega JT, Gallagher JM, McKee AG, Tang Y, Carmena-Bargueňo M, Azam M, Pashandi Z, Golczak M, Meiler J, Pérez-Sánchez H, Schlebach JP, Jastrzebska B
Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA.
1. Commun Biol - published January 1, 2025
2. Megrian D, Martinez M, Alzari PM, Wehenkel AM
Conditional requirement for dimerization of the membrane-binding module for BTK signaling in lymphocyte cell lines.
1. Sci Signal - published January 1, 2025
2. Eisen TJ, Ghaffari-Kashani S, Hung CL, Groves JT, Weiss A, Kuriyan J
Structure of transmembrane AMPA receptor regulatory protein subunit γ2.
1. Nat Commun - published January 1, 2025
2. Hale WD, Romero AM, Koylass N, Warrick CR, Qiu Z, Huganir RL, Twomey EC
Mitoregulin self-associates to form likely homo-oligomeric pore-like complexes.
1. iScience - published January 1, 2025
2. Linzer CR, Stein CS, Witmer NH, Xu Z, Schnicker NJ, Boudreau RL
Antigenic determinants underlying IgE-mediated anaphylaxis to peanut.
1. J Allergy Clin Immunol - published January 1, 2025
2. Smith SA, Khan YW, Shrem RA, Hemler JA, Doyle JE, Daniel J, Zhang J, Pena-Amelunxen G, Aglas L, Hamilton RG, Getts R, Sampson HA, Wong JJW, Croote D, Peebles RS Jr, Spiller BW
Directed evolution of an orthogonal transcription engine for programmable gene expression in eukaryotes.
1. iScience - published January 1, 2025
2. Kar S, Gardner EC, Javanmardi K, Boutz DR, Shroff R, Horton AP, Segall-Shapiro TH, Ellington AD, Gollihar J
OPTO: Automated Optimization for Solid-State NMR Spectroscopy.
1. J Am Chem Soc - published January 1, 2025
2. Borcik CG, DeZonia B, Ravula T, Harding BD, Garg R, Rienstra CM
Mechanistic determinants and dynamics of cA6 synthesis in type III CRISPR-Cas effector complexes.
1. Nucleic Acids Res - published January 1, 2025
2. Jungfer K, Moravčík Š, Garcia-Doval C, Knörlein A, Hall J, Jinek M
Coordinated neuron-specific splicing events restrict nucleosome engagement of the LSD1 histone demethylase complex.
1. Cell Rep - published January 1, 2025
2. Porter RS, An S, Gavilan MC, Nagai M, Murata-Nakamura Y, Zhou B, Bonefas KM, Dionne O, Manuel JM, St-Germain J, Gascon S, Kim J, Browning L, Laurent B, Cho US, Iwase S
Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross-stage recognition of glutamate-rich repeats.
1. Elife - published January 1, 2025
2. Amen A, Yoo R, Fabra-García A, Bolscher J, Stone WJR, Bally I, Dergan-Dylon S, Kucharska I, de Jong RM, de Bruijni M, Bousema T, King CR, MacGill RS, Sauerwein RW, Julien JP, Poignard P, Jore MM
Mapping C. difficile TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling.
1. mBio - published January 1, 2025
2. Ward JS, Schreiber KJ, Tam J, Youn J-Y, Melnyk RA
Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential.
1. Adv Sci (Weinh) - published January 1, 2025
2. Wei K, Arlotto M, Overhulse JM, Dinh TA, Zhou Y, Dupper NJ, Yang J, Kashemirov BA, Dawi H, Garnaud C, Bourgine G, Mietton F, Champleboux M, Larabi A, Hayat Y, Indorato RL, Noirclerc-Savoye M, Skoufias D, Cornet M, Rabut G, McKenna CE, Petosa C, Govin J
The reversible capillary field effect transistor: a capillaric element for autonomous flow switching.
1. Lab Chip - published January 1, 2025
2. Mak D, Meffan C, Menges J, Marchant-Ludlow R, Hashemi A, Moore CP, Dobson RCJ, Nock V
Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity.
1. Nat Cancer - published January 1, 2025
2. Liang J, Vitale T, Zhang X, Jackson TD, Yu D, Jedrychowski M, Gygi SP, Widlund HR, Wucherpfennig KW, Puigserver P
Structural basis for metal ion transport by the human SLC11 proteins DMT1 and NRAMP1.
1. Nat Commun - published January 1, 2025
2. Liziczai M, Fuchs A, Manatschal C, Dutzler R
Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns.
1. ACS Chem Biol - published January 1, 2025
2. Fedorova O, Luo M, Jagdmann GE Jr, Van Zandt MC, Sisto L, Pyle AM
Structural development of the HIV-1 apex-directed PGT145-PGDM1400 antibody lineage.
1. Cell Rep - published January 1, 2025
2. Mason RD, Zhang B, Morano NC, Shen CH, McKee K, Heimann A, Du R, Nazzari AF, Hodges S, Kanai T, Lin BC, Louder MK, Doria-Rose NA, Zhou T, Shapiro L, Roederer M, Kwong PD, Gorman J
Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering.
1. Nat Commun - published January 1, 2025
2. Grubbe WS, Zhang B, Kauffman A, Byléhn F, Padoł K, Jung HG, Park SB, Priest JM, Özkan E, de Pablo JJ, Liang TJ, Zhao M, Mendoza JL
Structural basis for the interaction between the Drosophila RTK Sevenless (dROS1) and the GPCR BOSS.
1. Nat Commun - published January 1, 2025
2. Zhang J, Tsutsui Y, Li H, Li T, Wang Y, Laraki S, Alarcon-Frias S, Stayrook SE, Klein DE
IgA class switching enhances neutralizing potency against SARS-CoV-2 by increased antibody hinge flexibility.
1. Antiviral Res - published January 1, 2025
2. Xu M, Zhang Z, Sun Y, Mai H, Liu S, Liu S, Lv K, Yu F, Wang Y, Yue X, Zhang J, Cai X, Zhao R, Lu H, Liu L, Luo H, Zhao H, Wang Y, Gong P, Chen S, Jing X, Zhao J, Chen YQ
Backbone and Sidechain (1)H, (15)N and (13)C Resonance Assignments of a Multidrug Efflux Membrane Protein using Solution and Solid-State NMR.
1. bioRxiv - published January 1, 2025
2. Harding BD, Hiett A, Tonelli M, Wang S, Rienstra CM, Henzler-Wildman KA
Improving the solubility of pseudo-hydrophobic chemicals through co-crystal formulation.
1. PNAS Nexus - published January 1, 2025
2. Janilkarn-Urena I, Tse A, Lin J, Tafolla-Aguirre B, Idrissova A, Zhang M, Skinner SG, Mostowfi N, Kim J, Kalapatapu N, Chang X, Efthymiou C, Williams CK, Magaki SD, Vinters HV, Gonen T, Ahmed SK, Gukasyan HJ, Davies DL, Seidler PM
Structures and mRNP remodeling mechanism of the TREX-2 complex.
1. Structure - published January 1, 2025
2. Xie Y, Clarke BP, Xie D, Mei M, Bhat P, Hill PS, Angelos AE, Çağatay T, Haider M, Collier SE, Chambers MG, Aksenova V, Dasso M, Fontoura BMA, Ren Y
Q-score as a reliability measure for protein, nucleic acid, and small molecule atomic coordinate models derived from 3DEM density maps.
1. bioRxiv - published January 1, 2025
2. Pintilie G, Shao C, Wang Z, Hudson BP, Flatt JW, Schmid MF, Morris K, Burley SK, Chiu W
Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects.
1. bioRxiv - published January 1, 2025
2. Vigneron SF, Ohno S, Braz J, Kim JY, Kweon OS, Webb C, Billesbølle C, Bhardwaj K, Irwin J, Manglik A, Basbaum AI, Ellman JA, Shoichet BK
Ribosomal protein phylogeography offers quantitative insights into the efficacy of genome-resolved surveys of microbial communities.
1. bioRxiv - published January 1, 2025
2. Schechter MS, Trigodet F, Veseli IA, Miller SE, Klein ML, Sever M, Maignien L, Delmont TO, Light SH, Eren AM
Dimerization and dynamics of angiotensin-I converting enzyme revealed by cryoEM and MD simulations.
1. bioRxiv - published January 1, 2025
2. Mancl JM, Wu X, Zhao M, Tang WJ
IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy.
1. bioRxiv - published January 1, 2025
2. Jiang H, Limsuwannarot S, Kulhanek KR, Pal A, Rysavy LW, Su L, Labiad O, Testa S, Ogana H, Waghray D, Tao P, Jude KM, Seet CS, Crooks GM, Moding EJ, Garcia KC, Kalbasi A
Resistance mechanisms and therapeutic strategies of CDK4 and CDK6 kinase targeting in cancer.
1. Nat Cancer - published January 1, 2025
2. Asciolla JJ, Wu X, Adamopoulos C, Gavathiotis E, Poulikakos PI
Whither the protein landscape?
1. Struct Dyn - published January 1, 2025
2. Carter CW Jr, Phillips GN Jr