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142 Member Publications for February 2025

CFAP410 has a bimodular architecture with a conserved surface patch on its N-terminal leucine-rich repeat motif for binding interaction partners.
1. Front Cell Dev Biol - published February 28, 2025
2. Stadler A, Gabriel HB, De Liz LV, Alonso-Gil S, Deng X, Crickley R, Korbula K, Mikolaskova B, Vaughan S, Huang K, Žagrović B, Sunter JD, Dong G
An FDA-approved drug structurally and phenotypically corrects the K210del mutation in genetic cardiomyopathy models.
1. J Clin Invest - published February 17, 2025
2. Wang P, Ahmed MS, Nguyen NUN, Menendez-Montes I, Hsu CC, Farag AB, Thet S, Lam NT, Wansapura JP, Crossley E, Ma N, Zhao SR, Zhang T, Morimoto S, Singh R, Elhelaly W, Tassin TC, Cardoso AC, Williams NS, Pointer HL, Elliott DA, McNamara JW, Watt KI, Porrello ER, Sadayappan S, Sadek HA
EndoMAP.v1, a Structural Protein Complex Landscape of Human Endosomes.
1. bioRxiv - published February 9, 2025
2. Gonzalez-Lozano MA, Schmid EW, Whelan EM, Jiang Y, Paulo JA, Walter JC, Harper JW
Real-time capture of σ(N) transcription initiation intermediates reveals mechanism of ATPase-driven activation by limited unfolding.
1. bioRxiv - published February 8, 2025
2. Mueller AU, Molina N, Darst SA
The tetracycline resistome is shaped by selection for specific resistance mechanisms by each antibiotic generation.
1. Nat Commun - published February 7, 2025
2. Blake KS, Xue YP, Gillespie VJ, Fishbein SRS, Tolia NH, Wencewicz TA, Dantas G
Single-stranded DNA binding to the transcription factor PafBC triggers the mycobacterial DNA damage response.
1. Sci Adv - published February 7, 2025
2. Schilling CM, Zdanowicz R, Rabl J, Müller AU, Boehringer D, Glockshuber R, Weber-Ban E
Advancing structure modeling from cryo-EM maps with deep learning.
1. Biochem Soc Trans - published February 7, 2025
2. Li S, Terashi G, Zhang Z, Kihara D
C10-Benzoate Esters of Anhydrotetracycline Inhibit Tetracycline Destructases and Recover Tetracycline Antibacterial Activity.
1. ACS Infect Dis - published February 6, 2025
2. Williford EE, Xue YP, Tang WK, Li R, Jones KV, Blake KS, Blaine HC, Lian X, Stallings CL, Tolia NH, Dantas G, Wencewicz TA
Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter.
1. Elife - published February 6, 2025
2. Goyal P, Dhanabalan K, Scalise M, Friemann R, Indiveri C, Dobson RCJ, Vinothkumar KR, Ramaswamy S
Electrosome assembly: Structural insights from high voltage-activated calcium channel (CaV)-chaperone interactions.
1. Biochem Soc Trans - published February 6, 2025
2. Chen Z, Minor DL Jr
Structural mapping of polyclonal IgG responses to HA after influenza virus vaccination or infection.
1. mBio - published February 6, 2025
2. León AN, Rodriguez AJ, Richey ST, Torrents de la Pena A, Wolters RM, Jackson AM, Webb K, Creech CB, Yoder S, Mudd PA, Crowe JE Jr, Han J, Ward AB
Determination of Pseudomonas aeruginosa MexXY-OprM substrate profile in a major efflux knockout system reveals distinct antibiotic substrate classes.
1. Microbiol Spectr - published February 6, 2025
2. Kavanaugh LG, Hariharan SM, Conn GL
Concurrent and consolidative carboplatin plus nab-paclitaxel or paclitaxel in locally advanced NSCLC A multicenter, randomized clinical trial.
1. Int J Radiat Oncol Biol Phys - published February 6, 2025
2. Zhang Y, Laine AM, Iyengar P, Westover KD, Dowell JE, Hughes RS, Christie A, Mickel T, Attia A, Villaruz L, Chen Y, Spigel DR, Socinski MA, Timmerman RD, Gerber DE
Cryo-electron microscopy reveals a single domain antibody with a unique binding epitope on fibroblast activation protein alpha.
1. RSC Chem Biol - published February 6, 2025
2. Xu Z, Sinha A, Pandya DN, Schnicker NJ, Wadas TJ
Coordination between ESCRT function and Rab conversion during endosome maturation.
1. EMBO J - published February 5, 2025
2. Ott DP, Desai S, Solinger JA, Kaech A, Spang A
Nano-Polymers as Cas9 Inhibitors.
1. Polymers (Basel) - published February 5, 2025
2. Chepurna O, Chatterjee A, Li Y, Ding H, Murali R, Black KL, Sun T
High-resolution Cryo-EM Structure Determination of a-Synuclein-A Prototypical Amyloid Fibril.
1. Bio Protoc - published February 5, 2025
2. Sanchez JC, Pierson JA, Borcik CG, Rienstra CM, Wright ER
Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis.
1. Cell Metab - published February 4, 2025
2. Liu R, Ren X, Park YE, Feng H, Sheng X, Song X, AminiTabrizi R, Shah H, Li L, Zhang Y, Abdullah KG, Dubois-Coyne S, Lin H, Cole PA, DeBerardinis RJ, McBrayer SK, Huang H, Zhao Y
How can we make sound replication decisions?
1. Proc Natl Acad Sci U S A - published February 4, 2025
2. Davis-Stober CP, Sarafoglou A, Aczel B, Chandramouli SH, Errington TM, Field SM, Fishbach A, Freire J, Ioannidis JPA, Oberauer K, Pestilli F, Ressl S, Schad DJ, Ter Schure J, Tentori K, van Ravenzwaaij D, Vandekerckhove J, Gundersen OE
Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease.
1. Proc Natl Acad Sci U S A - published February 4, 2025
2. Feng Y, Goncalves MM, Jitkova Y, Keszei AFA, Yan Y, Sarathy C, St-Germain J, Kenney TMG, Tcheng M, Trudel V, Mancini RS, Upadhyay R, Hurren R, Gronda M, Schultz M, Soriano K, Lees K, Pomroy NC, Currie SQW, Privé GG, Reed MA, Yudin AK, Penn LZ, Arrowsmith CH, Raught B, Mazhab-Jafari MT, Vahidi S, Schimmer AD
The chloroplast RNA-binding protein CP29A supports rbcL expression during cold acclimation.
1. Proc Natl Acad Sci U S A - published February 4, 2025
2. Lenzen B, Rösch F, Legen J, Ruwe H, Kachariya N, Sattler M, Small I, Schmitz-Linneweber C
Design of a light and Ca(2+) switchable organic-peptide hybrid.
1. Proc Natl Acad Sci U S A - published February 4, 2025
2. Khaleel ZH, No YH, Kim NH, Bae DH, Wu Y, Kim S, Choi H, Lee DE, Jeong SY, Ko YJ, Kim SG, Suh M, Kim JC, DeGrado WF, Kim KH, Kim YH
Zinc-limited Mycobacterium tuberculosis stimulate distinct responses in macrophages compared with standard zinc-replete bacteria.
1. Infect Immun - published February 4, 2025
2. Marcantonio E, Burger AD, Chang KH, Hoffmann FW, Fu Y, Khadka VS, Smagghe BJ, Deng Y, Hoffmann PR, Prisic S
A universal method for the purification of C2H2 zinc finger arrays.
1. PLoS One - published February 4, 2025
2. Liang J, Azubel M, Wang G, Nie Y, Kornberg RD, Beel AJ, Mattei PJ
Role of sortase-assembled Ebp pili in Enterococcus faecalis adhesion to iron oxides and its impact on extracellular electron transfer.
1. Microbiol Spectr - published February 4, 2025
2. Ho FK, Lam LN, Matysik A, Watts TD, Wong JJ, Chong KKL, Choo PY, Tolar J, Low PM, Chua ZS, Paxman JJ, Heras B, Marsili E, Ajo-Franklin CM, Kline KA
Increasing the Efficiency of Ensemble Molecular Dynamics Simulations with Termination of Unproductive Trajectories Identified at Runtime.
1. J Phys Chem A - published February 4, 2025
2. Marquez J, Cuendet MA, Caino-Lores S, Estrada T, Deelman E, Weinstein H, Taufer M
Neuronal constitutive endolysosomal perforations enable α-synuclein aggregation by internalized PFFs.
1. J Cell Biol - published February 3, 2025
2. Sanyal A, Scanavachi G, Somerville E, Saminathan A, Nair A, Bango Da Cunha Correia RF, Aylan B, Sitarska E, Oikonomou A, Hatzakis NS, Kirchhausen T
Anti-Ebola virus mAb 3A6 protects highly viremic animals from fatal outcome via binding GP((1,2)) in a position elevated from the virion membrane.
1. Nat Commun - published February 3, 2025
2. Hastie KM, Salie ZL, Ke Z, Halfmann PJ, DeWald LE, McArdle S, Grinyó A, Davidson E, Schendel SL, Hariharan C, Norris MJ, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook MR, Doranz B, Crozier I, Kawaoka Y, Branco LM, Kuhn JH, Briggs JAG, Worwa G, Davis CW, Ahmed R, Saphire EO
The assembly factor Reh1 is released from the ribosome during its initial round of translation.
1. Nat Commun - published February 3, 2025
2. Musalgaonkar S, Yelland JN, Chitale R, Rao S, Ozadam H, Taylor DW, Cenik C, Johnson AW
Aerolysin Nanopore Structures Revealed at High Resolution in a Lipid Environment.
1. J Am Chem Soc - published February 3, 2025
2. Anton JS, Iacovache I, Bada Juarez JF, Abriata LA, Perrin LW, Cao C, Marcaida MJ, Zuber B, Dal Peraro M
Deletion of ESX-3 and ESX-4 secretion systems in Mycobacterium abscessus results in highly impaired pathogenicity.
1. Commun Biol - published February 3, 2025
2. Daher W, Le Moigne V, Tasrini Y, Parmar S, Sexton DL, Aguilera-Correa JJ, Berdal V, Tocheva EI, Herrmann JL, Kremer L
Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3' End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain.
1. J Med Chem - published February 3, 2025
2. Das RS, Datta D, Brown CR, Gilbert JA, Chan A, Willoughby J, Gupta S, Kim M, Degaonkar R, Racie T, Lei L, Schlegel MK, Castoreno A, Charisse K, Rajeev KG, Egli M, Manoharan M
The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition.
1. Structure - published February 3, 2025
2. Kennedy AE, Barczewski AH, Arnoldy CR, Pennington JP, Tiernan KA, Hidalgo MB, Reilly CC, Wongsri T, Ragusa MJ, Grigoryan G, Mierke DF, Pellegrini M
Combinatorial mapping of E3 ubiquitin ligases to their target substrates.
1. Mol Cell - published February 3, 2025
2. Suiter CC, Calderon D, Lee DS, Chiu M, Jain S, Chardon FM, Lee C, Daza RM, Trapnell C, Zheng N, Shendure J
Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution.
1. Cell - published February 3, 2025
2. Hsu AY, Huang Q, Pi X, Fu J, Raghunathan K, Ghimire L, Balasubramanian A, Xie X, Yu H, Loison F, Haridas V, Zha J, Liu F, Park SY, Bagale K, Ren Q, Fan Y, Zheng Y, Cancelas JA, Chai L, Stowell SR, Chen K, Xu R, Wang X, Xu Y, Zhang L, Cheng T, Ma F, Thiagarajah JR, Wu H, Feng S, Luo HR
MERS-CoV spike vaccine-induced N-terminal domain-specific antibodies are more protective than receptor binding domain-specific antibodies.
1. iScience - published February 2, 2025
2. Abiona OM, Wang N, Leist SR, Schäfer A, Cockrell AS, Wang L, Bangaru S, Stevens L, Graham RL, Kocher JF, Tsybovsky Y, Kanekiyo M, Kumar A, Morabito KM, Rosen O, Shi W, Werner A, Zhang Y, Ziwawo C, Dzuvor CKO, Palandjian C, Eastman C, Matthews HR, Joseph J, Chappell JD, Kong WP, Mascola JR, Ward AB, Denison MR, Baric R, McLellan JS, Graham BS, Corbett-Helaire KS
Integrative analysis of KCNQ1 variants reveals molecular mechanisms of type 1 long QT syndrome pathogenesis.
1. Proc Natl Acad Sci U S A - published February 2, 2025
2. Brewer KR, Vanoye CG, Huang H, Clowes Moster KR, Desai RR, Hayes JB, Burnette DT, George AL, Sanders CR
Sequence-dependent scale for translocon-mediated insertion of interfacial helices in membranes.
1. Sci Adv - published February 2, 2025
2. Grau B, Kormos R, Bañó-Polo M, Chen K, García-Murria MJ, Hajredini F, Sánchez Del Pino MM, Jo H, Martínez-Gil L, von Heijne G, DeGrado WF, Mingarro I
Structural dynamics of human fatty acid synthase in the condensing cycle.
1. Nature - published February 2, 2025
2. Choi W, Li C, Chen Y, Wang Y, Cheng Y
A FAIR-Compliant Management Solution for Molecular Simulation Trajectories.
1. J Chem Inf Model - published February 2, 2025
2. Vitalis A, Winkler S, Zhang Y, Widmer J, Caflisch A
Haspin kinase binds to a nucleosomal DNA supergroove.
1. Nat Struct Mol Biol - published February 2, 2025
2. Hicks CW, Gliech CR, Rahman S, Zhang X, Eneim AS, Vasquez SJ, Holland AJ, Wolberger C
Development of Zafirlukast Analogues for Improved Antithrombotic Activity Through Thiol Isomerase Inhibition.
1. Arterioscler Thromb Vasc Biol - published February 2, 2025
2. Keovilay JA, Howard KC, Taylor KA, Khan S, Wurl SE, Szahaj MK, Sage T, Chandrika NT, Hou C, Tsodikov OV, Gibbins JM, Garneau-Tsodikova S, Kennedy DR
A structural atlas of death domain fold proteins reveals their versatile roles in biology and function.
1. Proc Natl Acad Sci U S A - published February 2, 2025
2. Wu EJ, Kandalkar AT, Ehrmann JF, Tong AB, Zhang J, Cong Q, Wu H
Structural basis of aquaporin-4 autoantibody binding in neuromyelitis optica.
1. Sci Adv - published February 2, 2025
2. Gupta M, Khandelwal NK, Nelson A, Hwang P, Pourmal S, Bennett JL, Stroud RM
MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation.
1. Mol Oncol - published February 2, 2025
2. Guérin C, Vinchent A, Fernandes M, Damour I, Laratte A, Tellier R, Estevam GO, Meneboo JP, Villenet C, Descarpentries C, Fraser JS, Figeac M, Cortot AB, Rouleau E, Tulasne D
De Novo Design of Proteins That Bind Naphthalenediimides, Powerful Photooxidants with Tunable Photophysical Properties.
1. J Am Chem Soc - published February 2, 2025
2. Mann SI, Lin Z, Tan SK, Zhu J, Widel ZXW, Bakanas I, Mansergh JP, Liu R, Kelly MJS, Wu Y, Wells JA, Therien MJ, DeGrado WF
Phage parasites targeting phage homologous recombinases provide antiviral immunity.
1. Nat Commun - published February 2, 2025
2. Debiasi-Anders G, Qiao C, Salim A, Li N, Mir-Sanchis I
Structural basis of siderophore export and drug efflux by Mycobacterium tuberculosis.
1. Nat Commun - published February 2, 2025
2. Earp JC, Garaeva AA, Meikle V, Niederweis M, Seeger MA
The structure of basal body inner junctions from Tetrahymena revealed by electron cryo-tomography.
1. EMBO J - published February 2, 2025
2. Li S, Fernandez JJ, Ruehle MD, Howard-Till RA, Fabritius A, Pearson CG, Agard DA, Winey ME
Bespoke Activity-Based Probes Reveal that the Pseudomonas aeruginosa Endoglycosidase, PslG, Is an Endo-β-glucanase.
1. J Am Chem Soc - published February 2, 2025
2. Ruijgrok G, Offen WA, Pickles IB, Raju D, Patsos T, de Boer C, Ofman T, Rompa J, van Oord D, Dodson EJ, Beekers A, Voskuilen T, Ferrari M, Wu L, Janssen APA, Codée JDC, Howell PL, Davies GJ, Overkleeft HS
Inhibitors of Lysinoalanine Cross-Linking in the Flagella Hook as Antimicrobials against Spirochetes.
1. ACS Chem Biol - published February 2, 2025
2. Lynch MJ, Kurniyati K, Deshpande M, Charon NW, Li C, Crane BR
Fission yeast metabolome dynamics during phosphate starvation and replenishment.
1. mBio - published February 2, 2025
2. Sanchez AM, Kyaw AK, Violante SN, Garg A, Cross JR, Shuman S
DET1 dynamics underlie cooperative ubiquitination by CRL4(DET1-COP1) complexes.
1. Sci Adv - published February 2, 2025
2. Burgess AE, Loughran TA, Turk LS, Nyvall HG, Dunlop JL, Jamieson SA, Curry JR, Burke JE, Filipcik P, Brown SHJ, Mace PD
The synaptonemal complex aligns meiotic chromosomes by wetting.
1. Sci Adv - published February 2, 2025
2. Gordon SG, Rodriguez AA, Gu Y, Corbett KD, Lee CF, Rog O
The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation.
1. Nature - published February 2, 2025
2. Stacey JCV, Hrebík D, Nand E, Shetty SD, Qu K, Boicu M, Anders-Össwein M, Uchil PD, Dick RA, Mothes W, Kräusslich HG, Müller B, Briggs JAG
Highly efficient photocatalytic removal of NO and synchronous inhibition of NO(2)via heterojunction formed by ZnAl-LDH and MXene-Ti(3)C(2)-derived TiO(2)@C.
1. J Hazard Mater - published February 2, 2025
2. Wu K, Tang Y, Qiu Y, Zhou H, Liu X, Wang P, He Y, Pan S, Fang Y, Fu M, Wei S, Dong F
Structure of the human K(2P)13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.
1. Nat Struct Mol Biol - published February 2, 2025
2. Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL Jr
Too much of a good thing: Lessons from compromised rootworm Bt maize in the US Corn Belt.
1. Science - published February 2, 2025
2. Ye Z, DiFonzo C, Hennessy DA, Zhao J, Wu F, Conley SP, Gassmann AJ, Hodgson EW, Jensen B, Knodel JJ, McManus B, Meinke LJ, Michel A, Potter B, Seiter NJ, Smith JL, Spencer JL, Tilmon KJ, Wright RJ, Krupke CH
TIGR-Tas: A family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses.
1. Science - published February 2, 2025
2. Faure G, Saito M, Wilkinson ME, Quinones-Olvera N, Xu P, Flam-Shepherd D, Kim S, Reddy N, Zhu S, Evgeniou L, Koonin EV, Macrae RK, Zhang F
The MEK inhibitor trametinib is effective in inhibiting the growth of canine oral squamous cell carcinoma.
1. Sci Rep - published February 2, 2025
2. Katt WP, Balkman CE, Butler SD, Byron M, Carney PC, Todd-Donato AB, Drozd ME, Duhamel GE, Evans JM, Fiani N, Ford JC, Grenier JK, Hayward JJ, Heikinheimo K, Hume KR, Moore ES, Puri R, Sylvester SR, Warshaw SL, Webb SM, White AC, Wright AL, Cerione RA, Peralta S
Cancer hotspot mutations rewire ERK2 specificity by selective exclusion of docking interactions.
1. J Biol Chem - published February 2, 2025
2. Robles JT, Stiegler AL, Boggon TJ, Turk BE
Multiple fingerprinting and cardioprotective activity of Salvia miltiorrhiza polysaccharides.
1. Int J Biol Macromol - published February 2, 2025
2. Wang D, Zhang X, Bian Z, Zhang Z, Liu X, Zhang C, Liu Q, Ding J, Zhu L, Liu Y
Structure Characterization of Bacterial Microcompartment Shells via X-ray Scattering and Coordinate Modeling: Evidence for Adventitious Capture of Cytoplasmic Proteins.
1. ACS Appl Bio Mater - published February 2, 2025
2. Zuo X, Jussupow A, Ponomarenko NS, Grant TD, Tefft NM, Yadav NS, Range KL, Ralston CY, TerAvest MA, Sutter M, Kerfeld CA, Vermaas JV, Feig M, Tiede DM
International Precision Child Health Partnership (IPCHiP): an initiative to accelerate discovery and improve outcomes in rare pediatric disease.
1. NPJ Genom Med - published February 2, 2025
2. Howell KB, White SM, McTague A, D'Gama AM, Costain G, Poduri A, Scheffer IE, Chau V, Smith LD, Stephenson SEM, Wojcik M, Davidson A, Sebire N, Sliz P, Beggs AH, Chitty LS, Cohn RD, Marshall CR, Andrews NC, North KN, Cross JH, Christodoulou J, Scherer SW
Custom affinity probes reveal DNA-damage-induced, ssDNA-independent chromatin SUMOylation in budding yeast.
1. Cell Rep - published February 2, 2025
2. Tröster V, Wong RP, Börgel A, Cakilkaya B, Renz C, Möckel MM, Eifler-Olivi K, Marinho J, Reinberg T, Furler S, Schaefer JV, Plückthun A, Wolf E, Ulrich HD
Protocol for sequence clustering with PaSiMap in Jalview.
1. STAR Protoc - published February 2, 2025
2. Morell T, Procter J, Barton GJ, Diederichs K, Mayans O, Fleming JR
Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states.
1. Nat Commun - published February 2, 2025
2. MacTavish BS, Zhu D, Shang J, Shao Q, He Y, Yang ZJ, Kamenecka TM, Kojetin DJ
Antibiotic target discovery by integrated phenotypic and activity-based profiling of electrophilic fragments.
1. Cell Chem Biol - published February 2, 2025
2. Jin Y, Jana S, Abbasov ME, Lin H
A strain-transcending anti-AMA1 human monoclonal antibody neutralizes malaria parasites independent of direct RON2L receptor blockade.
1. Cell Rep Med - published February 2, 2025
2. Patel PN, Diouf A, Dickey TH, Tang WK, Hopp CS, Traore B, Long CA, Miura K, Crompton PD, Tolia NH
Coupling Subunit-Specific States to Allosteric Regulation in Homodimeric Cyclooxygenase-2.
1. Biochemistry - published February 2, 2025
2. Dong L, Malkowski MG
Considerations for capsid-targeting antiretrovirals in pre-exposure prophylaxis.
1. Trends Mol Med - published February 2, 2025
2. McFadden WM, Faerch M, Kirby KA, Dick RA, Torbett BE, Sarafianos SG
Structural basis of error-prone DNA synthesis by DNA polymerase θ.
1. Nat Commun - published February 2, 2025
2. Li C, Maksoud LM, Gao Y
Antigenic drift expands influenza viral escape pathways from recalled humoral immunity.
1. Immunity - published February 2, 2025
2. Maurer DP, Vu M, Schmidt AG
PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation.
1. Lab Invest - published February 2, 2025
2. Fang R, Vallius T, Zhang A, Van Cura D, Alicandri F, Fischer G, Draper E, Xu S, Pelletier R, Wang J, Mandinova A, Katsyv I, Sorger PK, Murphy GF, Lian CG
Human glutathione transferases catalyze the reaction between glutathione and nitrooleic acid.
1. J Biol Chem - published February 2, 2025
2. Steglich M, Larrieux N, Zeida A, Rizza JD, Salvatore SR, Bonilla M, Möller MN, Buschiazzo A, Alvarez B, Schopfer FJ, Turell L
Mechanistic insights into protein biogenesis and maturation on the ribosome.
1. J Mol Biol - published February 2, 2025
2. Lentzsch A, Lee JH, Shan SO
Temporal dynamics of immune cell transcriptomics in brain metastasis progression influenced by gut microbiome dysbiosis.
1. Cell Rep - published February 2, 2025
2. Golomb SM, Guldner IH, Aleksandrovic E, Fross SR, Liu X, Diao L, Liang K, Wu J, Wang Q, Lopez JA, Zhang S
Structure-Property Relationships of Elastomeric Vinylogous Urethane Thermosets and Their Application as Closed-Loop Recyclable Strain Sensors.
1. Macromolecules - published February 2, 2025
2. Ma Y, Stellacci F
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma.
1. bioRxiv - published February 2, 2025
2. Nardone C, Gao J, Seo HS, Mintseris J, Ort L, Yip MCJ, Negasi M, Besschetnova AK, Kamitaki N, Gygi SP, Dhe-Paganon S, Munshi N, Fulciniti M, Greenberg ME, Shao S, Elledge SJ, Gu X
Ligand Screening and Discovery using Cocktail Soaking and Automated MicroED.
1. bioRxiv - published February 2, 2025
2. Lin J, Gallenito MJ, Hattne J, Gonen T
Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer.
1. bioRxiv - published February 2, 2025
2. Mahmoud A, Choi PH, Sukhwa C, Pintar J, Walch H, Zhao N, Bermeo J, Chung S, Raghavan M, Bapat S, Jiang Q, Karagkounis G, Meredith J, Giarrizzo M, Firat C, Cercek A, Foote MB, Schultz N, Chatila WK, Nash GM, Shia J, Sanchez-Vega F, Larson S, Dar AC, Rosen N, Ganesh K
Genomics-Informed Drug Repurposing Strategy Identifies Novel Therapeutic Targets for Metabolic Dysfunction-Associated Steatotic Liver Disease.
1. medRxiv - published February 2, 2025
2. Seagle HM, Akerele AT, DeCorte JA, Hellwege JN, Breeyear JH, Kim J, Levin M, Khodurksy S, Bress A, Lee K, Meiler J, Gill D, Lee JS, Heberer K, Miller DR, Reaven P, Chang KM, Lynch JA, Khankari NK, Shuey MM, Edwards TL, Vujkovic M
Cryo-EM structures of the Plant Augmin reveal its intertwined coiled-coil assembly, antiparallel dimerization and NEDD1 binding mechanisms.
1. bioRxiv - published February 2, 2025
2. Ashaduzzaman M, Taheri A, Lee YJ, Tang Y, Guo F, Fried SD, Liu B, Al-Bassam J
Strategy for identification of characteristic components from multiphase of Sanwu Huangqin Decoction via UHPLC‒Q-TOF‒MS and UHPLC-QQQ-MS combined with multivariate statistical analysis.
1. J Chromatogr A - published February 2, 2025
2. Wang S, Wang T, He J, Mao W, Gong P, He J, Xiao X, Lu S, Hong Y, Guo Y
A novel L-RNA aptamer to regulate the pUG fold RNA-induced gene expression in vivo.
1. Nucleic Acids Res - published February 2, 2025
2. Liew SW, Cao D, Petersen RJ, Butcher SE, Kennedy SG, Kwok CK
RNA Modifications and Prp24 Coordinate Lsm2-8 Binding Dynamics during S. cerevisiae U6 snRNP Assembly.
1. bioRxiv - published February 2, 2025
2. Liu Y, Nomura Y, Butcher SE, Hoskins AA
Mosquito Cell Atlas: A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito.
1. bioRxiv - published February 2, 2025
2. Goldman OV, DeFoe AE, Qi Y, Jiao Y, Weng SC, Houri-Zeevi L, Lakhiani P, Morita T, Razzauti J, Rosas-Villegas A, Tsitohay YN, Walker MM, Hopkins BR, Mosquito Cell Atlas Consortium, Akbari OS, Duvall LB, White-Cooper H, Sorrells TR, Sharma R, Li H, Vosshall LB, Shai N
Revealing Functional Hotspots: Temperature-Dependent Crystallography of K-RAS Highlights Allosteric and Druggable Sites.
1. bioRxiv - published February 2, 2025
2. Deck SL, Xu M, Milano SK, Cerione RA
Lipid-mediated mechanism of drug extrusion by a heterodimeric ABC exporter.
1. bioRxiv - published February 2, 2025
2. Tang Q, Sinclair M, Bisignano P, Zhang Y, Tajkhorshid E, Mchaourab HS
Serendipitous high-resolution structure of Escherichia coli carbonic anhydrase 2.
1. Acta Crystallogr F Struct Biol Commun - published February 1, 2025
2. Rankin MR, Smith JL
Structural insights into the role of the prosegment binding loop in a papain-superfamily cysteine protease from Treponema denticola.
1. Acta Crystallogr F Struct Biol Commun - published February 1, 2025
2. Clark ND, Li C, Malkowski MG
Modelling a pathological GSX2 variant that selectively alters DNA binding reveals hypomorphic mouse brain defects.
1. Dis Model Mech - published February 1, 2025
2. Tweedie L, Riccetti MR, Cain B, Qin S, Salomone J, Webb JA, Riesenberg A, Ehrman LA, Waclaw RR, Kovall RA, Gebelein B, Campbell K
Genome-wide transcriptome differences associated with perceived discrimination in an urban, community-dwelling middle-aged cohort.
1. FASEB J - published February 1, 2025
2. Pacheco NL, Noren Hooten N, Wu SF, Mensah-Bonsu M, Zhang Y, Chitrala KN, De S, Mode NA, Ezike N, Beatty Moody DL, Zonderman AB, Evans MK
Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition.
1. Cancer Res - published February 1, 2025
2. Madorsky Rowdo FP, Martini R, Ackermann SE, Tang CP, Tranquille M, Irizarry A, Us I, Alawa O, Moyer JE, Sigouros M, Nguyen J, Al Assaad M, Cheng E, Ginter PS, Manohar J, Stonaker B, Boateng R, Oppong JK, Adjei EK, Awuah B, Kyei I, Aitpillah FS, Adinku MO, Ankomah K, Osei-Bonsu EB, Gyan KK, Hoda S, Newman L, Mosquera JM, Sboner A, Elemento O, Dow LE, Davis MB, Martin ML
The C2 domain augments Ras GTPase-activating protein catalytic activity.
1. Proc Natl Acad Sci U S A - published February 1, 2025
2. Paul ME, Chen D, Vish KJ, Lartey NL, Hughes E, Freeman ZT, Saunders TL, Stiegler AL, King PD, Boggon TJ
Creating Optimal Western Blot Conditions for OPA1 Isoforms in Skeletal Muscle Cells and Tissue.
1. Curr Protoc - published February 1, 2025
2. Mungai M, Crabtree A, Le H, Moore J, Nguyen D, Rodriguez B, Harris C, Stephens DC, Beasley HK, Garza-Lopez E, Neikirk K, Shao B, Oliver A, Wilson G, Bacevac S, Vang L, Vue Z, Vue N, Marshall AG, Turner K, Zaganjor E, Shao J, Murray S, Gaddy JA, Wanjalla C, Davis J, Damo SM, Banks LD, Hinton A Jr
Optimizing In Situ Proximity Ligation Assays for Mitochondria, ER, or MERC Markers in Skeletal Muscle Tissue and Cells.
1. Curr Protoc - published February 1, 2025
2. Crabtree A, Le H, Harris C, Oliver A, Barillas A, Moore J, Nguyen DN, Rabago IM, Rodriguez B, Stephens DC, Beasley HK, Garza-Lopez E, Neikirk K, Mungai M, Vang L, Vue Z, Vue N, Marshall AG, Turner K, Shao J, Murray S, Gaddy JA, Wanjalla C, Davis J, Damo S, Hinton AO Jr
In-clinic vitreous biopsy peel pack technique.
1. Int J Retina Vitreous - published February 1, 2025
2. DeBoer C, Zhao C, Mruthyunjaya P, Mahajan VB, Wai KM, Sanislo SR
TRiC Is a Structural Component of Mammalian Sperm Axonemes.
1. Cytoskeleton (Hoboken) - published February 1, 2025
2. Brown A, Leung MR, Zeev-Ben-Mordehai T, Zhang R
The Mutually Inspiring Biological and Chemical Synthesis of Fungal Bicyclo[2.2.2]diazaoctane Indole Alkaloids.
1. Chem Rev - published February 1, 2025
2. Du L, Dian L, Newmister SA, Xia Y, Luo G, Sherman DH, Li S
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase.
1. Nat Struct Mol Biol - published February 1, 2025
2. Zhao D, Wu X, Rapoport TA
Distinct Acyl Carrier Protein Docking Sites Help Mediate the Opposite Stereoselectivities of A- and B-type Modular Polyketide Synthase Ketoreductases.
1. Biochemistry - published February 1, 2025
2. Ray KA, Lin SN, Keatinge-Clay AT
Unique mechanisms to increase structural stability and enhance antigen binding in nanobodies.
1. Structure - published February 1, 2025
2. Ketaren NE, Fridy PC, Malashkevich V, Sanyal T, Brillantes M, Thompson MK, Oren DA, Bonanno JB, Šali A, Almo SC, Chait BT, Rout MP
UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors.
1. Nature - published February 1, 2025
2. Yeo MJR, Zhang O, Xie X, Nam E, Payne NC, Gosavi PM, Kwok HS, Iram I, Lee C, Li J, Chen NJ, Nguyen K, Jiang H, Wang ZA, Lee K, Mao H, Harry SA, Barakat IA, Takahashi M, Waterbury AL, Barone M, Mattevi A, Carr SA, Udeshi ND, Bar-Peled L, Cole PA, Mazitschek R, Liau BB, Zheng N
VARP binds SNX27 to promote endosomal supercomplex formation on membranes.
1. Sci Adv - published February 1, 2025
2. Chandra M, Kendall AK, Ford MGJ, Jackson LP
Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations.
1. Nature - published February 1, 2025
2. Xie X, Zhang O, Yeo MJR, Lee C, Tao R, Harry SA, Payne NC, Nam E, Paul L, Li Y, Kwok HS, Jiang H, Mao H, Hadley JL, Lin H, Batts M, Gosavi PM, D'Angiolella V, Cole PA, Mazitschek R, Northcott PA, Zheng N, Liau BB
Structural basis of disease mutation and substrate recognition by the human SLC2A9 transporter.
1. Proc Natl Acad Sci U S A - published February 1, 2025
2. Khandelwal NK, Gupta M, Kumar P, Balasubramani SG, Echeverria I, Stroud RM
Progress toward a comprehensive brain protein interactome.
1. Biochem Soc Trans - published February 1, 2025
2. Dang V, Voigt B, Marcotte EM
Self-supervised machine learning methods for protein design improve sampling but not the identification of high-fitness variants.
1. Sci Adv - published February 1, 2025
2. Ertelt M, Moretti R, Meiler J, Schoeder CT
Structural and kinetic analysis of distinct active and inactive states of Burkholderia cenocepacia orotate phosphoribosyltransferase.
1. Arch Biochem Biophys - published February 1, 2025
2. Sharma N, Turlington ZR, Zupko SP, Catoggio MN, Lukacs CM, Serbzhinskiy D, Abendroth J, Edwards TE, Lorimer DD, Barrera G, Willis S, Beyer O, Toay S, Da Li T, Torelli AT, Hicks KA, French JB
How Ligands Achieve Biased Signaling toward Arrestins.
1. Biochemistry - published February 1, 2025
2. Jiang Q, Che T
Fragment-Based Approach for Hierarchical Nanotube Assembly of Small Molecules in Aqueous Phase.
1. Chemistry - published February 1, 2025
2. Zia A, Yi M, Liu Z, Wang F, Xu B
Mechanism of dimer selectivity and binding cooperativity of BRAF inhibitors.
1. Elife - published February 1, 2025
2. Clayton J, Romany A, Matenoglou E, Gavathiotis E, Poulikakos PI, Shen J
CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting.
1. Elife - published February 1, 2025
2. Wu Y, Yan Y, Yang Y, Bian S, Rivetta A, Allen K, Sigworth FJ
Male-male interactions shape mate selection in Drosophila.
1. Cell - published February 1, 2025
2. Hindmarsh Sten T, Li R, Hollunder F, Eleazer S, Ruta V
Adapting a Trapped Ion Mobility Spectrometry-Q-TOF for High m/z Native Mass Spectrometry and Surface-Induced Dissociation.
1. Anal Chem - published February 1, 2025
2. Lin YF, Jones BJ, Ridgeway ME, Panczyk EM, Somogyi A, Kaplan DA, Marathe I, Yun S, Kirby KA, Sarafianos SG, Laganowsky AD, Park MA, Wysocki VH
Removal of Homogeneous Broadening from (1)H-Detected Multidimensional Solid-State NMR Spectra.
1. Anal Chem - published February 1, 2025
2. Perras FA, Wang S, Mayer J, Halder M, Paterson AL, Culver DB, Rienstra CM
Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning.
1. Elife - published February 1, 2025
2. Estevam GO, Linossi E, Rao J, Macdonald CB, Ravikumar A, Chrispens KM, Capra JA, Coyote-Maestas W, Pimentel H, Collisson EA, Jura N, Fraser JS
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST.
1. Cell Metab - published February 1, 2025
2. Sprenger HG, Mittenbühler MJ, Sun Y, Van Vranken JG, Schindler S, Jayaraj A, Khetarpal SA, Smythers AL, Vargas-Castillo A, Puszynska AM, Spinelli JB, Armani A, Kunchok T, Ryback B, Seo HS, Song K, Sebastian L, O'Young C, Braithwaite C, Dhe-Paganon S, Burger N, Mills EL, Gygi SP, Paulo JA, Arthanari H, Chouchani ET, Sabatini DM, Spiegelman BM
Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila.
1. PLoS Biol - published February 1, 2025
2. M'Angale PG, Lemieux A, Liu Y, Wang S, Zinter M, Alegre G, Simkin A, Budnik V, Kelch BA, Thomson T
Rhodamine6G and Hœchst33342 narrow BmrA conformational spectrum for a more efficient use of ATP.
1. Nat Commun - published February 1, 2025
2. Gobet A, Moissonnier L, Zarkadas E, Magnard S, Bettler E, Martin J, Terreux R, Schoehn G, Orelle C, Jault JM, Falson P, Chaptal V
Cryo-EM structures of Nipah virus polymerase complex reveal highly varied interactions between L and P proteins among paramyxoviruses.
1. Protein Cell - published February 1, 2025
2. Xue L, Chang T, Gui J, Li Z, Zhao H, Zou B, Lu J, Li M, Wen X, Gao S, Zhan P, Rong L, Feng L, Gong P, He J, Chen X, Xiong X
A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma.
1. Sci Transl Med - published February 1, 2025
2. Rendo V, Lee EQ, Bossi C, Khuu N, Rudek MA, Pal S, Azazmeh N, Rashid R, Lin JR, Cusick M, Reynolds ARN, Fassinou ACR, Ayoub G, Malinowski S, Lapinskas E, Pisano W, Jeang J, Stopka SA, Regan MS, Spetz J, Desai A, Lieberman F, Palanichamy K, Fisher JD, Pelton K, Huang RY, Sarosiek KA, Nabors LB, Holdhoff M, Danda N, Strowd R, Desideri S, Walbert T, Ye X, Chakravarti A, Sorger PK, Santagata S, Agar NYR, Grossman SA, Alexander BM, Wen PY, Ligon KL, Beroukhim R
Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins.
1. Cell - published February 1, 2025
2. Zilberzwige-Tal S, Altae-Tran H, Kannan S, Wilkinson ME, Vo SC, Strebinger D, Edmonds KK, Yao CJ, Mears KS, Shmakov SA, Makarova KS, Macrae RK, Koonin EV, Zhang F
Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel.
1. Nat Commun - published February 1, 2025
2. Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM
Integration of New Approach Methods for the Assessment of Data Poor Chemicals.
1. Toxicol Sci - published February 1, 2025
2. Paul Friedman K, Thomas RS, Wambaugh JF, Harrill JA, Judson RS, Shafer TJ, Williams AJ, Lee JJ, Loo LH, Gagné M, Long AS, Barton-Maclaren TS, Whelan M, Bouhifd M, Rasenberg M, Simanainen U, Sobanski T
Conformational variants of I-A(k) MHC class II molecules carry distinct immunopeptidomes.
1. Mol Immunol - published February 1, 2025
2. Drake LA, Ramos RB, Denzin LK, Nanaware PP, Stern LJ, Drake JR
Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread.
1. Sci Transl Med - published February 1, 2025
2. Pahmeier F, Monticelli SR, Feng X, Hjorth CK, Wang A, Kuehne AI, Bakken RR, Batchelor TG, Lee SE, Middlecamp M, Stuart L, Duarte-Neto AN, Abelson DM, McLellan JS, Biering SB, Herbert AS, Chandran K, Harris E
Development of chronic obstructive pulmonary disease after a tuberculosis episode in a large, population-based cohort from Eastern China.
1. Int J Epidemiol - published February 1, 2025
2. Wang J, Yu L, Yang Z, Shen P, Sun Y, Shui L, Tang M, Jin M, Chen B, Ge Y, Lin H, Shen Y, Chen K, Martinez L
Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M(pro)) with Noncovalent Preclinical Candidate, Mpro61.
1. ACS Bio Med Chem Au - published February 1, 2025
2. Kenneson JR, Papini C, Tang S, Huynh K, Zhang CH, Jorgensen WL, Anderson KS
A dendritic guidance receptor functions in both ligand dependent and independent modes.
1. bioRxiv - published February 1, 2025
2. Reddy AR, Machera SJ, Cook ZT, Özkan E, Shen K
Short 5' UTRs serve as a marker for viral mRNA translation inhibition by the IFIT2-IFIT3 antiviral complex.
1. bioRxiv - published February 1, 2025
2. Glasner DR, Todd C, Cook B, D'Urso A, Khosla S, Estrada E, Wagner JD, Bartels MD, Ford P, Prych J, Hatch K, Yee BA, Ego KM, Liang Q, Holland SR, Case JB, Corbett KD, Diamond MS, Yeo GW, Herzik MA Jr, Van Nostrand EL, Daugherty MD
A Putative Binding Model of Nitazene Derivatives at the μ-Opioid Receptor.
1. bioRxiv - published February 1, 2025
2. Clayton J, Shi L, Robertson MJ, Skiniotis G, Michaelides M, Stavitskaya L, Shen J
Cryo-EM analysis of the Bacillus thuringiensis extrasporal matrix identifies F-ENA as a widespread family of endospore appendages across the Firmicutes phylum.
1. bioRxiv - published February 1, 2025
2. Sleutel M, Sogues A, Van Gerven N, Jonsmoen UL, Van Molle I, Fislage M, Theunissen LD, Bellis NF, Baquero DP, Egelman EH, Krupovic M, Wang F, Aspholm M, Remaut H
Structure of endogenous Pfs230:Pfs48/45 in complex with potent malaria transmission-blocking antibodies.
1. bioRxiv - published February 1, 2025
2. Bekkering ET, Yoo R, Hailemariam S, Heide F, Ivanochko D, Jackman M, Proellochs NI, Stoter R, Wanders OT, van Daalen RC, Inklaar MR, Andrade CM, Jansen PWTC, Vermeulen M, Bousema T, Rubinstein JL, Kooij TWA, Jore MM, Julien JP
A vector-based strategy for olfactory navigation in Drosophila.
1. bioRxiv - published February 1, 2025
2. Siliciano AF, Minni S, Morton C, Dowell CK, Eghbali NB, Rhee JY, Abbott LF, Ruta V
Low-Dose Docetaxel Is Effective in Reducing Atherogenic Lipids and Atherosclerosis.
1. Int J Mol Sci - published February 1, 2025
2. Choi HY, Ruel I, Choi S, Iatan I, Choi S, Lee JY, Genest J
Architecture remodeling activates the HerA-DUF anti-phage defense system.
1. Mol Cell - published February 1, 2025
2. Rish AD, Fosuah E, Shen Z, Marathe IA, Wysocki VH, Fu TM
Phosphorylation-State Modulated Binding of HSP70: Structural Insights and Compensatory Protein Engineering.
1. bioRxiv - published February 1, 2025
2. Stewart M, Paththamperuma C, McCann C, Cottingim K, Zhang H, DelVecchio R, Peng I, Fennimore E, Nix JC, Saeed MN, George K, Makaroff K, Colie M, Paulakonis E, Almeida MF, Afolayan AJ, Brown NG, Page RC, Schisler JC
Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response.
1. bioRxiv - published February 1, 2025
2. San Felipe CJ, Batra J, Muralidharan M, Malpotra S, Anand D, Bauer R, Verba KA, Swaney DL, Krogan NJ, Grabe M, Fraser JS
Generation of antigen-specific paired chain antibody sequences using large language models.
1. bioRxiv - published February 1, 2025
2. Wasdin PT, Johnson NV, Janke AK, Held S, Marinov TM, Jordaan G, Vandenabeele L, Pantouli F, Gillespie RA, Vukovich MJ, Holt CM, Kim J, Hansman G, Logue J, Chu HY, Andrews SF, Kanekiyo M, Sautto GA, Ross TM, Sheward DJ, McLellan JS, Abu-Shmais AA, Georgiev IS
Deep Learning of Proteins with Local and Global Regions of Disorder.
1. ArXiv - published February 1, 2025
2. Zhang O, Liu ZH, Forman-Kay JD, Head-Gordon T