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153 Member Publications for March 2024

Case report: Long-term follow-up of patients who received a FimCH vaccine for prevention of recurrent urinary tract infections caused by antibiotic resistant Enterobacteriaceae: a case report series.
1. Front Immunol - published March 28, 2024
2. Perer E, Stacey H, Eichorn T, Hughey H, Lawrence J, Cunningham E, Johnson MO, Bacon K, Kau A, Hultgren SJ, Hooton TM, Harris JL
Predispose, precipitate, perpetuate, and protect: how diet and the gut influence mental health in emerging adulthood.
1. Front Nutr - published March 20, 2024
2. Warren M, O'Connor C, Lee JE, Burton J, Walton D, Keathley J, Wammes M, Osuch E
Predictors of seasonal influenza and COVID-19 vaccination coverage among adults in Tennessee during the COVID-19 pandemic.
1. Front Public Health - published March 19, 2024
2. Cunningham-Erves J, George W, Sanderson M, Stewart E, Jin SW, Davis J, Brandt HM
Sequence and structural insights of monoleucine-based sorting motifs contained within the cytoplasmic domains of basolateral proteins.
1. Front Cell Dev Biol - published March 18, 2024
2. Harmych SJ, Tydings CW, Meiler J, Singh B
Computational identification of antibody-binding epitopes from mimotope datasets.
1. Front Bioinform - published March 11, 2024
2. Li R, Wilderotter S, Stoddard M, Van Egeren D, Chakravarty A, Joseph-McCarthy D
Lipid droplets as substrates for protein phase separation.
1. Biophys J - published March 9, 2024
2. Kamatar A, Bravo JPK, Yuan F, Wang L, Lafer EM, Taylor DW, Stachowiak JC, Parekh SH
Specific protein-RNA interactions are mostly preserved in biomolecular condensates.
1. Sci Adv - published March 8, 2024
2. de Vries T, Novakovic M, Ni Y, Smok I, Inghelram C, Bikaki M, Sarnowski CP, Han Y, Emmanouilidis L, Padroni G, Leitner A, Allain FH
Expanding FTMap for Fragment-Based Identification of Pharmacophore Regions in Ligand Binding Sites.
1. J Chem Inf Model - published March 8, 2024
2. Khan O, Jones G, Lazou M, Joseph-McCarthy D, Kozakov D, Beglov D, Vajda S
Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum.
1. mBio - published March 8, 2024
2. Sun SY, Segev-Zarko L-a, Pintilie GD, Kim CY, Staggers SR, Schmid MF, Egan ES, Chiu W, Boothroyd JC
GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer.
1. Nat Commun - published March 8, 2024
2. Ye Z, Xu S, Shi Y, Cheng X, Zhang Y, Roy S, Namjoshi S, Longo MA, Link TM, Schlacher K, Peng G, Yu D, Wang B, Tainer JA, Ahmed Z
Highly multiplexed design of an allosteric transcription factor to sense novel ligands.
1. bioRxiv - published March 8, 2024
2. Nishikawa KK, Chen J, Acheson JF, Harbaugh SV, Huss P, Frenkel M, Novy N, Sieren HR, Lodewyk EC, Lee DH, Chávez JL, Fox BG, Raman S
Enhancing prime editor activity by directed protein evolution in yeast.
1. Nat Commun - published March 7, 2024
2. Weber Y, Böck D, Ivașcu A, Mathis N, Rothgangl T, Ioannidi EI, Blaudt AC, Tidecks L, Vadovics M, Muramatsu H, Reichmuth A, Marquart KF, Kissling L, Pardi N, Jinek M, Schwank G
Structure-Activity Relationships of Natural and Semisynthetic Plecomacrolides Suggest Distinct Pathways for HIV-1 Immune Evasion and Vacuolar ATPase-Dependent Lysosomal Acidification.
1. J Med Chem - published March 7, 2024
2. McCauley M, Huston M, Condren AR, Pereira F, Cline J, Yaple-Maresh M, Painter MM, Zimmerman GE, Robertson AW, Carney N, Goodall C, Terry V, Müller R, Sherman DH, Collins KL
Biosensor and machine learning-aided engineering of an amaryllidaceae enzyme.
1. Nat Commun - published March 7, 2024
2. d'Oelsnitz S, Diaz DJ, Kim W, Acosta DJ, Dangerfield TL, Schechter MW, Minus MB, Howard JR, Do H, Loy JM, Alper HS, Zhang YJ, Ellington AD
Structural bases for stoichiometry-selective calcium potentiation of a neuronal nicotinic receptor.
1. Br J Pharmacol - published March 7, 2024
2. Mazzaferro S, Kang G, Natarajan K, Hibbs RE, Sine SM
Restraint validation of biomolecular structures determined by NMR in the Protein Data Bank.
1. Structure - published March 7, 2024
2. Baskaran K, Ploskon E, Tejero R, Yokochi M, Harrus D, Liang Y, Peisach E, Persikova I, Ramelot TA, Sekharan M, Tolchard J, Westbrook JD, Bardiaux B, Schwieters CD, Patwardhan A, Velankar S, Burley SK, Kurisu G, Hoch JC, Montelione GT, Vuister GW, Young JY
Structural and dynamic changes in P-Rex1 upon activation by PIP(3) and inhibition by IP(4).
1. bioRxiv - published March 6, 2024
2. Ravala SK, Adame-Garcia SR, Li S, Chen CL, Cianfrocco MA, Gutkind JS, Cash JN, Tesmer JJG
Small vs. Large Library Docking for Positive Allosteric Modulators of the Calcium Sensing Receptor.
1. bioRxiv - published March 6, 2024
2. Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Levit Kaplan A, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G
Dorsolateral prefrontal activity supports a cognitive space organization of cognitive control.
1. Elife - published March 6, 2024
2. Yang G, Wu H, Li Q, Liu X, Fu Z, Jiang J
Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening.
1. RSC Chem Biol - published March 6, 2024
2. Ortiz G, Longbotham JE, Qin SL, Zhang MY, Lee GM, Neitz RJ, Kelly MJS, Arkin MR, Fujimori DG
Deletions initiated by the vaccinia virus TopIB protein in yeast.
1. DNA Repair (Amst) - published March 6, 2024
2. Cho JE, Shaltz S, Yakovleva L, Shuman S, Jinks-Robertson S
Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy.
1. bioRxiv - published March 6, 2024
2. Schnicker NJ, Xu Z, Amir M, Gakhar L, Huang CL
Crimean-Congo Hemorrhagic Fever Survivors Elicit Protective Non-Neutralizing Antibodies that Target 11 Overlapping Regions on Viral Glycoprotein GP38.
1. bioRxiv - published March 6, 2024
2. Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra A, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Sec7 regulatory domains scaffold autoinhibited and active conformations.
1. Proc Natl Acad Sci U S A - published March 5, 2024
2. Brownfield BA, Richardson BC, Halaby SL, Fromme JC
Structural basis for CFTR inhibition by CFTR(inh)-172.
1. Proc Natl Acad Sci U S A - published March 5, 2024
2. Young PG, Levring J, Fiedorczuk K, Blanchard SC, Chen J
Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses.
1. Proc Natl Acad Sci U S A - published March 5, 2024
2. Kretsch RC, Xu L, Zheludev IN, Zhou X, Huang R, Nye G, Li S, Zhang K, Chiu W, Das R
Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria.
1. Nat Commun - published March 5, 2024
2. Junk L, Schmiedel VM, Guha S, Fischel K, Greb P, Vill K, Krisilia V, van Geelen L, Rumpel K, Kaur P, Krishnamurthy RV, Narayanan S, Shandil RK, Singh M, Kofink C, Mantoulidis A, Biber P, Gmaschitz G, Kazmaier U, Meinhart A, Leodolter J, Hoi D, Junker S, Morreale FE, Clausen T, Kalscheuer R, Weinstabl H, Boehmelt G
An alphacoronavirus polymerase structure reveals conserved replication factor functions.
1. Nucleic Acids Res - published March 5, 2024
2. Anderson TK, Hoferle PJ, Chojnacki KJ, Lee KW, Coon JJ, Kirchdoerfer RN
Asymmetric Synthesis of α-Chloroamides via Photoenzymatic Hydroalkylation of Olefins.
1. J Am Chem Soc - published March 5, 2024
2. Liu Y, Bender SG, Sorigue D, Diaz DJ, Ellington AD, Mann G, Allmendinger S, Hyster TK
Comparative analysis of human, rodent and snake deltavirus replication.
1. PLoS Pathog - published March 5, 2024
2. Khalfi P, Denis Z, McKellar J, Merolla G, Chavey C, Ursic-Bedoya J, Soppa L, Szirovicza L, Hetzel U, Dufourt J, Leyrat C, Goldmann N, Goto K, Verrier E, Baumert TF, Glebe D, Courgnaud V, Gregoire D, Hepojoki J, Majzoub K
A novel micropeptide, Slitharin, exerts cardioprotective effects in myocardial infarction.
1. Proteomics Clin Appl - published March 5, 2024
2. Ibrahim AGE, Ciullo A, Yamaguchi S, Li C, Antes T, Jones X, Li L, Murali R, Maslennikov I, Sundararaman N, Soetkamp D, Cingolani E, Van Eyk J, Marbán E
Highly Reactive Group I Introns Ubiquitous in Pathogenic Fungi.
1. J Mol Biol - published March 5, 2024
2. Liu T, Pyle AM
Optimization of Conditions of Zanthoxylum Alkylamides Liposomes by Response Surface Methodology and the Absorption Characteristics of Liposomes in the Caco-2 Cell Monolayer Model.
1. ACS Omega - published March 5, 2024
2. Wang R, Rao C, Liu Q, Liu X
Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior.
1. bioRxiv - published March 5, 2024
2. Zeledon EV, Baxt LA, Khan TA, Michino M, Miller M, Huggins DJ, Jiang CS, Vosshall LB, Duvall LB
Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine.
1. PLoS Pathog - published March 4, 2024
2. Ma R, Salinas ND, Orr-Gonzalez S, Richardson B, Ouahes T, Torano H, Jenkins BJ, Dickey TH, Neal J, Duan J, Morrison RD, Gittis AG, Doritchamou JYA, Zaidi I, Lambert LE, Duffy PE, Tolia NH
Intergenerational Caregiving Patterns and Cognitive Health among the Sandwich Generation Within Four-Generation Families.
1. Int J Aging Hum Dev - published March 4, 2024
2. Shi J, Zhang D, Liu X
Filament formation drives catalysis by glutaminase enzymes important in cancer progression.
1. Nat Commun - published March 4, 2024
2. Feng S, Aplin C, Nguyen TT, Milano SK, Cerione RA
Structural Requirements for Activity of Mind bomb1 in Notch Signaling.
1. bioRxiv - published March 3, 2024
2. Cao R, Gozlan O, Tveriakhina L, Zhou H, Jiang H, Cole PA, Aster JC, Sprinzak D, Blacklow SC
RNA polymerase SI3 domain modulates global transcriptional pausing and pause-site fluctuations.
1. Nucleic Acids Res - published March 3, 2024
2. Bao Y, Cao X, Landick R
A phage nucleus-associated RNA-binding protein is required for jumbo phage infection.
1. Nucleic Acids Res - published March 3, 2024
2. Enustun E, Armbruster EG, Lee J, Zhang S, Yee BA, Malukhina K, Gu Y, Deep A, Naritomi JT, Liang Q, Aigner S, Adler BA, Cress BF, Doudna JA, Chaikeeratisak V, Cleveland DW, Ghassemian M, Bintu B, Yeo GW, Pogliano J, Corbett KD
The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design.
1. Nucleic Acids Res - published March 3, 2024
2. Malard F, Wolter AC, Marquevielle J, Morvan E, Ecoutin A, Rüdisser SH, Allain FHT, Campagne S
Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.
1. Biochem J - published March 2, 2024
2. Velagapudi UK, Rouleau-Turcotte É, Billur R, Shao X, Patil M, Black BE, Pascal JM, Talele TT
Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements.
1. Commun Biol - published March 2, 2024
2. Finci LI, Chakrabarti M, Gulten G, Finney J, Grose C, Fox T, Yang R, Nissley DV, McCormick F, Esposito D, Balius TE, Simanshu DK
PTEN loss in glioma cell lines leads to increased extracellular vesicles biogenesis and PD-L1 cargo in a PI3K-dependent manner.
1. bioRxiv - published March 2, 2024
2. Sanchez JC, Pierpont TM, Argueta-Zamora D, Wilson K, August A, Cerione RA
SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1 to control nucleo-cytoplasmic transport.
1. Mol Biol Cell - published March 2, 2024
2. Makio T, Zhang K, Love N, Mast FD, Liu X, Elaish M, Hobman T, Aitchison JD, Fontoura BMA, Wozniak RW
Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP.
1. Nat Commun - published March 2, 2024
2. Liu H, Zakrzewicz D, Nosol K, Irobalieva RN, Mukherjee S, Bang-Sørensen R, Goldmann N, Kunz S, Rossi L, Kossiakoff AA, Urban S, Glebe D, Geyer J, Locher KP
Structure and assembly of a bacterial gasdermin pore.
1. Nature - published March 2, 2024
2. Johnson AG, Mayer ML, Schaefer SL, McNamara-Bordewick NK, Hummer G, Kranzusch PJ
Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis.
1. Nature - published March 2, 2024
2. Eckartt KA, Delbeau M, Munsamy-Govender V, DeJesus MA, Azadian ZA, Reddy AK, Chandanani J, Poulton NC, Quiñones-Garcia S, Bosch B, Landick R, Campbell EA, Rock JM
Potent Inhibition of E. coli DXP Synthase by a gem-Diaryl Bisubstrate Analog.
1. ACS Infect Dis - published March 2, 2024
2. Coco LB, Toci EM, Chen PY, Drennan CL, Freel Meyers CL
HDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker.
1. Proc Natl Acad Sci U S A - published March 2, 2024
2. Chen R, Glauninger H, Kahan DN, Shangguan J, Sachleben JR, Riback JA, Drummond DA, Sosnick TR
Undiagnosed Disease Network collaborative approach in diagnosing rare disease in a patient with a mosaic CACNA1D variant.
1. Am J Med Genet A - published March 2, 2024
2. Ezell KM, Tinker RJ, Furuta Y, Gulsevin A, Bastarache L, Hamid R, Cogan JD, Rives L, Neumann S, Corner B, Kozuria M, Phillips JA 3rd, Undiagnosed Diseases Network
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates.
1. Nat Chem Biol - published March 2, 2024
2. Huang HT, Lumpkin RJ, Tsai RW, Su S, Zhao X, Xiong Y, Chen J, Mageed N, Donovan KA, Fischer ES, Sellers WR
Identification of clickable HIV-1 capsid-targeting probes for viral replication inhibition.
1. Cell Chem Biol - published March 2, 2024
2. McFadden WM, Casey-Moore MC, Bare GAL, Kirby KA, Wen X, Li G, Wang H, Slack RL, Snyder AA, Lorson ZC, Kaufman IL, Cilento ME, Tedbury PR, Gembicky M, Olson AJ, Torbett BE, Sharpless KB, Sarafianos SG
Bidirectional ATP-driven transport of cobalamin by the mycobacterial ABC transporter BacA.
1. Nat Commun - published March 2, 2024
2. Nijland M, Lefebvre SN, Thangaratnarajah C, Slotboom DJ
Structural analysis of the macrocyclic inhibitor BI-4020 binding to EGFR kinase.
1. ChemMedChem - published March 2, 2024
2. Beyett TS, Rana JK, Schaeffner IK, Heppner DE, Eck M
Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock.
1. Elife - published March 2, 2024
2. Tariq D, Maurici N, Bartholomai BM, Chandrasekaran S, Dunlap JC, Bah A, Crane BR
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis.
1. Sci Immunol - published March 2, 2024
2. Balasubramanian A, Hsu AY, Ghimire L, Tahir M, Devant P, Fontana P, Du G, Liu X, Fabin D, Kambara H, Xie X, Liu F, Hasegawa T, Xu R, Yu H, Chen M, Kolakowski S, Trauger S, Larsen MR, Wei W, Wu H, Kagan JC, Lieberman J, Luo HR
The HisRS-like domain of GCN2 is a pseudoenzyme that can bind uncharged tRNA.
1. Structure - published March 2, 2024
2. Yin JZ, Keszei AFA, Houliston S, Filandr F, Beenstock J, Daou S, Kitaygorodsky J, Schriemer DC, Mazhab-Jafari MT, Gingras AC, Sicheri F
A Tag-Free Platform for Synthesis and Screening of Cyclic Peptide Libraries.
1. Angew Chem Int Ed Engl - published March 2, 2024
2. Bruce A, Adebomi V, Czabala P, Palmer J, Bhardwaj G, Raj M, McFadden WM, Lorson ZC, Slack RL, Sarafianos SG
Profiling the proximal proteome of the activated μ-opioid receptor.
1. Nat Chem Biol - published March 2, 2024
2. Polacco BJ, Lobingier BT, Blythe EE, Abreu N, Khare P, Howard MK, Gonzalez-Hernandez AJ, Xu J, Li Q, Novy B, Naing ZZC, Shoichet BK, Coyote-Maestas W, Levitz J, Krogan NJ, Von Zastrow M, Hüttenhain R
Author Correction: Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis.
1. Cell Discov - published March 2, 2024
2. Casanova AG, Roth GS, Hausmann S, Lu X, Bischoff LJM, Froeliger EM, Belmudes L, Bourova-Flin E, Flores NM, Benitez AM, Chasan T, Caporicci M, Vayr J, Blanchet S, Ielasi F, Rousseaux S, Hainaut P, Gozani O, Le Romancer M, Couté Y, Palencia A, Mazur PK, Reynoird N
Rugged fitness landscapes minimize promiscuity in the evolution of transcriptional repressors.
1. Cell Syst - published March 2, 2024
2. Meger AT, Spence MA, Sandhu M, Matthews D, Chen J, Jackson CJ, Raman S
Activin E is a TGFβ ligand that signals specifically through activin receptor-like kinase 7.
1. Biochem J - published March 2, 2024
2. Vestal KA, Kattamuri C, Koyiloth M, Ongaro L, Howard JA, Deaton A, Ticau S, Dubey A, Bernard DJ, Thompson TB
Initial Primer Synthesis of a DNA Primase Monitored by Real-Time NMR Spectroscopy.
1. J Am Chem Soc - published March 2, 2024
2. Wu P, Zehnder J, Schröder N, Blümmel PEW, Salmon L, Damberger FF, Lipps G, Allain FH, Wiegand T
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF.
1. Nature - published March 2, 2024
2. Radko-Juettner S, Yue H, Myers JA, Carter RD, Robertson AN, Mittal P, Zhu Z, Hansen BS, Donovan KA, Hunkeler M, Rosikiewicz W, Wu Z, McReynolds MG, Roy Burman SS, Schmoker AM, Mageed N, Brown SA, Mobley RJ, Partridge JF, Stewart EA, Pruett-Miller SM, Nabet B, Peng J, Gray NS, Fischer ES, Roberts CWM
Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI.
1. Nat Commun - published March 2, 2024
2. Molina JJ, Kohler KN, Gager C, Andersen MJ, Wongso E, Lucas ER, Paik A, Xu W, Donahue DL, Bergeron K, Klim A, Caparon MG, Hultgren SJ, Desai A, Ploplis VA, Flick MJ, Castellino FJ, Flores-Mireles AL
FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins.
1. Nat Microbiol - published March 2, 2024
2. Rex EA, Seo D, Chappidi S, Pinkham C, Brito Oliveira S, Embry A, Heisler D, Liu Y, Munir M, Luger K, Alto NM, da Fonseca FG, Orchard R, Hancks DC, Gammon DB
Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose.
1. Mol Med - published March 2, 2024
2. Bloom J, Pantouris G, He M, Aljabari B, Mishra L, Manjula R, Parkins A, Lolis EJ, Al-Abed Y
Epitope Mapping of Japanese Encephalitis Virus Neutralizing Antibodies by Native Mass Spectrometry and Hydrogen/Deuterium Exchange.
1. Biomolecules - published March 2, 2024
2. Adhikari J, Heffernan J, Edeling M, Fernandez E, Jethva PN, Diamond MS, Fremont DH, Gross ML
Photocobilins integrate B(12) and bilin photochemistry for enzyme control.
1. Nat Commun - published March 2, 2024
2. Zhang S, Jeffreys LN, Poddar H, Yu Y, Liu C, Patel K, Johannissen LO, Zhu L, Cliff MJ, Yan C, Schirò G, Weik M, Sakuma M, Levy CW, Leys D, Heyes DJ, Scrutton NS
Kinetic Network Modeling with Molecular Simulation Inputs: A Proton-Coupled Phosphate Symporter.
1. Biophys J - published March 2, 2024
2. Liu Y, Li C, Gupta M, Stroud RM, Voth GA
Mastigoneme structure reveals insights into the O-linked glycosylation code of native hydroxyproline-rich helices.
1. Cell - published March 2, 2024
2. Dai J, Ma M, Niu Q, Eisert RJ, Wang X, Das P, Lechtreck KF, Dutcher SK, Zhang R, Brown A
Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.
1. Nat Commun - published March 2, 2024
2. Dhavale DD, Barclay AM, Borcik CG, Basore K, Berthold DA, Gordon IR, Liu J, Milchberg MH, O'Shea JY, Rau MJ, Smith Z, Sen S, Summers B, Smith J, Warmuth OA, Perrin RJ, Perlmutter JS, Chen Q, Fitzpatrick JAJ, Schwieters CD, Tajkhorshid E, Rienstra CM, Kotzbauer PT
Structural basis of Acinetobacter type IV pili targeting by an RNA virus.
1. Nat Commun - published March 2, 2024
2. Meng R, Xing Z, Chang JY, Yu Z, Thongchol J, Xiao W, Wang Y, Chamakura K, Zeng Z, Wang F, Young R, Zeng L, Zhang J
Engineering a Human P2X2 Receptor with Altered Ligand Selectivity in Yeast.
1. J Biol Chem - published March 2, 2024
2. Gardner EC, Tramont C, Bachanová P, Wang C, Do H, Boutz DR, Kar S, Zemelman BV, Gollihar JD, Ellington AD
Dramatic Changes in Mitochondrial Subcellular Location and Morphology Accompany Activation of the CO(2) Concentrating Mechanism.
1. bioRxiv - published March 2, 2024
2. Findinier J, Joubert LM, Schmid MF, Malkovskiy A, Chiu W, Burlacot A, Grossman AR
The Molecular Architecture of the Nuclear Basket.
1. bioRxiv - published March 2, 2024
2. Singh D, Soni N, Hutchings J, Echeverria I, Shaikh F, Duquette M, Suslov S, Li Z, van Eeuwen T, Molloy K, Shi Y, Wang J, Guo Q, Chait BT, Fernandez-Martinez J, Rout MP, Sali A, Villa E
Screening Carbon Nano Materials for preventing amyloid protein aggregation by adopting a facile method.
1. Res Sq - published March 2, 2024
2. Wilson DL, Carreon A, Chinnam S, Sharifan H, Ahlawat J, Narayan M
Enhancing cryo-EM structure prediction with DeepTracer and AlphaFold2 integration.
1. Brief Bioinform - published March 2, 2024
2. Chen J, Zia A, Luo A, Meng H, Wang F, Hou J, Cao R, Si D
Design and Synthesis of New GS-6207 Subtypes for Targeting HIV-1 Capsid Protein.
1. Int J Mol Sci - published March 2, 2024
2. Akther T, McFadden WM, Zhang H, Kirby KA, Sarafianos SG, Wang Z
Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway.
1. Int J Mol Sci - published March 2, 2024
2. Oyejobi GK, Yan X, Sliz P, Wang L
Lipidome Changes Associated with a Diet-Induced Reduction in Hepatic Fat among Adolescent Boys with Metabolic Dysfunction-Associated Steatotic Liver Disease.
1. Metabolites - published March 2, 2024
2. Huneault HE, Chen CY, Cohen CC, Liu X, Jarrell ZR, He Z, DeSantos KE, Welsh JA, Maner-Smith KM, Ortlund EA, Schwimmer JB, Vos MB
Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting.
1. bioRxiv - published March 1, 2024
2. Wu Y, Yan Y, Yang Y, Bian S, Rivetta A, Allen K, Sigworth FJ
Allosteric activation of the co-receptor BAK1 by the EFR receptor kinase initiates immune signaling.
1. bioRxiv - published March 1, 2024
2. Mühlenbeck H, Tsutsui Y, Lemmon MA, Bender KW, Zipfel C
Structure-based discovery of CFTR potentiators and inhibitors.
1. bioRxiv - published March 1, 2024
2. Liu F, Kaplan AL, Levring J, Einsiedel J, Tiedt S, Distler K, Omattage NS, Kondratov IS, Moroz YS, Pietz HL, Irwin JJ, Gmeiner P, Shoichet BK, Chen J
Probable digenic inheritance of Diamond-Blackfan anemia.
1. Am J Med Genet A - published March 1, 2024
2. Furuta Y, Tinker RJ, Gulsevin A, Neumann SM, Hamid R, Cogan JD, Rives L, Liu Q, Chen HC, Joos KM, Phillips JA 3rd, Undiagnosed Diseases Network
Analysis of the inter-domain orientation of tandem RRM domains with diverse linkers: connecting experimental with AlphaFold2 predicted models.
1. NAR Genom Bioinform - published March 1, 2024
2. Roca-Martínez J, Kang HS, Sattler M, Vranken W
Mucosal vaccine-induced cross-reactive CD8(+) T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection.
1. Nat Immunol - published March 1, 2024
2. Ying B, Darling TL, Desai P, Liang CY, Dmitriev IP, Soudani N, Bricker T, Kashentseva EA, Harastani H, Raju S, Liu M, Schmidt AG, Curiel DT, Boon ACM, Diamond MS
Modeling membrane geometries implicitly in Rosetta.
1. Protein Sci - published March 1, 2024
2. Woods H, Leman JK, Meiler J
Community recommendations on cryoEM data archiving and validation.
1. IUCrJ - published March 1, 2024
2. Kleywegt GJ, Adams PD, Butcher SJ, Lawson CL, Rohou A, Rosenthal PB, Subramaniam S, Topf M, Abbott S, Baldwin PR, Berrisford JM, Bricogne G, Choudhary P, Croll TI, Danev R, Ganesan SJ, Grant T, Gutmanas A, Henderson R, Heymann JB, Huiskonen JT, Istrate A, Kato T, Lander GC, Lok SM, Ludtke SJ, Murshudov GN, Pye R, Pintilie GD, Richardson JS, Sachse C, Salih O, Scheres SHW, Schroeder GF, Sorzano COS, Stagg SM, Wang Z, Warshamanage R, Westbrook JD, Winn MD, Young JY, Burley SK, Hoch JC, Kurisu G, Morris K, Patwardhan A, Velankar S
Author Correction: Mucosal vaccine-induced cross-reactive CD8(+) T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection.
1. Nat Immunol - published March 1, 2024
2. Ying B, Darling TL, Desai P, Liang CY, Dmitriev IP, Soudani N, Bricker T, Kashentseva EA, Harastani H, Raju S, Liu M, Schmidt AG, Curiel DT, Boon ACM, Diamond MS
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Combinatorial selective ER-phagy remodels the ER during neurogenesis.
1. Nat Cell Biol - published March 1, 2024
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Phosphorylation regulates tau's phase separation behavior and interactions with chromatin.
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A simple method to resolve rate constants when the binding mechanism obeys induced fit or conformational selection.
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Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral capsids that can be engineered for mRNA delivery.
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FacZ is a GpsB-interacting protein that prevents aberrant division-site placement in Staphylococcus aureus.
1. Nat Microbiol - published March 1, 2024
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Bacterial Lactonases ZenA with Noncanonical Structural Features Hydrolyze the Mycotoxin Zearalenone.
1. ACS Catal - published March 1, 2024
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Structure of RADX and mechanism for regulation of RAD51 nucleofilaments.
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Engineering an Escherichia coli strain for production of long single-stranded DNA.
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2. Shen K, Flood JJ, Zhang Z, Ha A, Shy BR, Dueber JE, Douglas SM
Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination.
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A solid beta-sheet structure is formed at the surface of FUS droplets during aging.
1. Nat Chem Biol - published March 1, 2024
2. Emmanouilidis L, Bartalucci E, Kan Y, Ijavi M, Pérez ME, Afanasyev P, Boehringer D, Zehnder J, Parekh SH, Bonn M, Michaels TCT, Wiegand T, Allain FH
Structural basis of human U5 snRNP late biogenesis and recycling.
1. Nat Struct Mol Biol - published March 1, 2024
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Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology.
1. Nat Commun - published March 1, 2024
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Catalytic residues of microRNA Argonautes play a modest role in microRNA star strand destabilization in C. elegans.
1. Nucleic Acids Res - published March 1, 2024
2. Kotagama K, Grimme AL, Braviner L, Yang B, Sakhawala RM, Yu G, Benner LK, Joshua-Tor L, McJunkin K
The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression.
1. Nat Commun - published March 1, 2024
2. Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer V
Contributions of Hyperactive Mutations in M(pro) from SARS-CoV-2 to Drug Resistance.
1. ACS Infect Dis - published March 1, 2024
2. Flynn JM, Zvornicanin SN, Tsepal T, Shaqra AM, Kurt Yilmaz N, Jia W, Moquin S, Dovala D, Schiffer CA, Bolon DNA
The intrinsically disordered linker in the single-stranded DNA-binding protein influences DNA replication restart and recombination pathways in Escherichia coli K-12.
1. J Bacteriol - published March 1, 2024
2. Sandler SJ, Bonde NJ, Wood EA, Cox MM, Keck JL
The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke.
1. J Med Chem - published March 1, 2024
2. Evans R, Bolduc PN, Pfaffenbach M, Gao F, May-Dracka T, Fang T, Hopkins BT, Chodaparambil JV, Henry KL, Li P, Metrick C, Nelson A, Trapa P, Thomas A, Burkly L, Peterson EA
Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells.
1. Immunity - published March 1, 2024
2. Bu W, Kumar A, Board NL, Kim J, Dowdell K, Zhang S, Lei Y, Hostal A, Krogmann T, Wang Y, Pittaluga S, Marcotrigiano J, Cohen JI
Phage-layer interferometry: a companion diagnostic for phage therapy and a bacterial testing platform.
1. Sci Rep - published March 1, 2024
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Altered conformational dynamics contribute to species-specific effects of cytochrome c mutations on caspase activation.
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Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking.
1. Nat Commun - published March 1, 2024
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Recent Advances in Automated Structure-Based De Novo Drug Design.
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De novo-designed transmembrane proteins bind and regulate a cytokine receptor.
1. Nat Chem Biol - published March 1, 2024
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Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
1. Science - published March 1, 2024
2. Mercer JAM, DeCarlo SJ, Roy Burman SS, Sreekanth V, Nelson AT, Hunkeler M, Chen PJ, Donovan KA, Kokkonda P, Tiwari PK, Shoba VM, Deb A, Choudhary A, Fischer ES, Liu DR
Combining machine learning with structure-based protein design to predict and engineer post-translational modifications of proteins.
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Designed Ankyrin Repeat Proteins as Actin Labels of Distinct Cytoskeletal Structures in Living Cells.
1. ACS Nano - published March 1, 2024
2. Ivanova JR, Benk AS, Schaefer JV, Dreier B, Hermann LO, Plückthun A, Missirlis D, Spatz JP
Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin.
1. Nat Commun - published March 1, 2024
2. Tonggu L, Wisedchaisri G, Gamal El-Din TM, Lenaeus MJ, Logan MM, Toma T, Du Bois J, Zheng N, Catterall WA
Engineered dityrosine-bonding of the RSV prefusion F protein imparts stability and potency advantages.
1. Nat Commun - published March 1, 2024
2. Gidwani SV, Brahmbhatt D, Zomback A, Bassie M, Martinez J, Zhuang J, Schulze J, McLellan JS, Mariani R, Alff P, Frasca D, Blomberg BB, Marshall CP, Yondola MA
Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models.
1. Nat Commun - published March 1, 2024
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A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma.
1. Cancer Res - published March 1, 2024
2. Hwang GH, Pazyra-Murphy MF, Seo HS, Dhe-Paganon S, Stopka SA, DiPiazza M, Sutter N, Gero TW, Volkert A, Ombelets L, Dittemore G, Rees MG, Ronan MM, Roth JA, Agar NYR, Scott DA, Segal RA
Potent HPIV3-neutralizing IGHV5-51 Antibodies Identified from Multiple Individuals Show L Chain and CDRH3 Promiscuity.
1. J Immunol - published March 1, 2024
2. Abu-Shmais AA, Miller RJ, Janke AK, Wolters RM, Holt CM, Raju N, Carnahan RH, Crowe JE Jr, Mousa JJ, Georgiev IS
Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication.
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A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α-primase.
1. Nat Struct Mol Biol - published March 1, 2024
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Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes.
1. Commun Biol - published March 1, 2024
2. Blake KS, Kumar H, Loganathan A, Williford EE, Diorio-Toth L, Xue YP, Tang WK, Campbell TP, Chong DD, Angtuaco S, Wencewicz TA, Tolia NH, Dantas G
Structural insights into vesicular monoamine storage and drug interactions.
1. Nature - published March 1, 2024
2. Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Engineering an Escherichia coli strain for production of long single-stranded DNA.
1. Nucleic Acids Res - published March 1, 2024
2. Shen K, Flood JJ, Zhang Z, Ha A, Shy BR, Dueber JE, Douglas SM
Mass Spectrometry-Based Method to Measure Aflatoxin B(1) DNA Adducts in Formalin-Fixed Paraffin-Embedded Tissues.
1. Chem Res Toxicol - published March 1, 2024
2. Bellamri M, Yao L, Tomar R, Vartanian V, Rizzo CJ, Stone MP, Groopman JD, Lloyd RS, Turesky RJ
Despite the odds: formation of the SARS-CoV-2 methylation complex.
1. Nucleic Acids Res - published March 1, 2024
2. Matsuda A, Plewka J, Rawski M, Mourão A, Zajko W, Siebenmorgen T, Kresik L, Lis K, Jones AN, Pachota M, Karim A, Hartman K, Nirwal S, Sonani R, Chykunova Y, Minia I, Mak P, Landthaler M, Nowotny M, Dubin G, Sattler M, Suder P, Popowicz GM, Pyrć K, Czarna A
Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement.
1. Anal Chem - published March 1, 2024
2. D'Ippolito RA, Rabara D, Blanco MA, Alberico E, Drew MR, Ramakrishnan N, Sontan D, Widmeyer SRT, Scheidemantle GM, Messing S, Turner D, Arkin M, Maciag AE, Stephen AG, Esposito D, McCormick F, Nissley DV, DeHart CJ
Identification of "Structural Pin" Interactions and Their Significance for the Conformational Control of Macrocyclic Scaffolds.
1. Angew Chem Int Ed Engl - published March 1, 2024
2. Appavoo SD, Heller NW, van Campenhout CT, Saunders GJ, Yudin AK
Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
1. Eur J Med Chem - published March 1, 2024
2. Legru A, Batista FA, Puszko AK, Bouillon A, Maurel M, Martinez M, Ejjoummany A, Ortega Varga L, Adler P, Méchaly A, Hadjadj M, Sosnowski P, Hopfgartner G, Alzari PM, Blondel A, Haouz A, Barale JC, Hernandez JF
Human endogenous retrovirus type K encoded Np9 oncoprotein induces DNA damage response.
1. J Med Virol - published March 1, 2024
2. Chen J, Fan J, Lin Z, Dai L, Qin Z
XPA tumor variant leads to defects in NER that sensitize cells to cisplatin.
1. NAR Cancer - published March 1, 2024
2. Blee AM, Gallagher KS, Kim HS, Kim M, Kharat SS, Troll CR, D'Souza A, Park J, Neufer PD, Schärer OD, Chazin WJ
Visualizing mitochondrial heme flow through GAPDH in living cells and its regulation by NO.
1. Redox Biol - published March 1, 2024
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IHMCIF: An Extension of the PDBx/mmCIF Data Standard for Integrative Structure Determination Methods.
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Response to Letter-to-the-editor: "Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA".
1. Mol Metab - published March 1, 2024
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Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection.
1. Cell - published March 1, 2024
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Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance.
1. Immunity - published March 1, 2024
2. Ogega CO, Skinner NE, Schoenle MV, Wilcox XE, Frumento N, Wright DA, Paul HT, Sinnis-Bourozikas A, Clark KE, Figueroa A, Bjorkman PJ, Ray SC, Flyak AI, Bailey JR
Cryogenic electron microscopy and tomography reveal imperfect icosahedral symmetry in alphaviruses.
1. PNAS Nexus - published March 1, 2024
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Linking the Autotaxin-LPA Axis to Medicinal Cannabis and the Endocannabinoid System.
1. Int J Mol Sci - published March 1, 2024
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Analysis of the Conformational Landscape of the N-Domains of the AAA ATPase p97: Disentangling the Continuous Conformational Variability in Partially Symmetrical Complexes.
1. Int J Mol Sci - published March 1, 2024
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Social state gates vision using three circuit mechanisms in Drosophila.
1. bioRxiv - published March 1, 2024
2. Schretter CE, Sten TH, Klapoetke N, Shao M, Nern A, Dreher M, Bushey D, Robie AA, Taylor AL, Branson KM, Otopalik A, Ruta V, Rubin GM
Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy.
1. bioRxiv - published March 1, 2024
2. Saecker RM, Mueller AU, Malone B, Chen J, Budell WC, Dandey VP, Maruthi K, Mendez JH, Molina N, Eng ET, Yen LY, Potter CS, Carragher B, Darst SA
TARGETING SOLUBLE AMYLOID-BETA OLIGOMERS WITH A NOVEL NANOBODY.
1. Res Sq - published March 1, 2024
2. Haynes JR, Whitmore CA, Behof WJ, Landman CA, Ong HH, Feld AP, Suero IC, Greer CB, Gore JC, Wijesinghe P, Matsubara JA, Wadzinski BE, Spiller BW, Pham W
Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation.
1. bioRxiv - published March 1, 2024
2. Kubinski HC, Despres HW, Johnson BA, Schmidt MM, Jaffrani SA, Mills MG, Lokugamage K, Dumas CM, Shirley DJ, Estes LK, Pekosz A, Crothers JW, Roychoudhury P, Greninger AL, Jerome KR, Di Genova BM, Walker DH, Ballif BA, Ladinsky MS, Bjorkman PJ, Menachery VD, Bruce EA
Versatile roles of protein flavinylation in bacterial extracyotosolic electron transfer.
1. bioRxiv - published March 1, 2024
2. Huang S, Méheust R, Barquera B, Light SH
A HIV-1 Gp41 Peptide-Liposome Vaccine Elicits Neutralizing Epitope-Targeted Antibody Responses in Healthy Individuals.
1. medRxiv - published March 1, 2024
2. Erdmann NB, Williams WB, Walsh SR, Grunenberg N, Edlefsen PT, Goepfert PA, Cain DW, Cohen KW, Maenza J, Mayer KH, Tieu HV, Sobieszczyk ME, Swann E, Lu H, De Rosa SC, Sagawa Z, Moody MA, Fox CB, Ferrari G, Edwards RJ, Acharya P, Alam SM, Parks R, Barr M, Tomaras GD, Montefiori DC, Gilbert PB, McElrath MJ, Corey L, Haynes BF, Baden LR, NIAID HVTN 133 Study Group
Three Prime Repair Exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural and conformational properties.
1. bioRxiv - published March 1, 2024
2. Prakash P, Khodke P, Balasubramaniam M, Davids BO, Hollis T, Davis J, Pandhare J, Kumbhar B, Dash C
Transcription factors ERα and Sox2 have differing multiphasic DNA and RNA binding mechanisms.
1. bioRxiv - published March 1, 2024
2. Hemphill WO, Steiner HR, Kominsky JR, Wuttke DS, Cech TR
Design principles for accurate folding of DNA origami.
1. bioRxiv - published March 1, 2024
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