Member Publications
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131 Member Publications for February 2024
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Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation.
- Cell - published February 29, 2024
- Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM, Cecchini M, Hibbs RE
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2'-(19)F labelling of ribose in RNAs: a tool to analyse RNA/protein interactions by NMR in physiological conditions.
- Front Mol Biosci - published February 29, 2024
- Kara H, Axer A, Muskett FW, Bueno-Alejo CJ, Paschalis V, Taladriz-Sender A, Tubasum S, Vega MS, Zhao Z, Clark AW, Hudson AJ, Eperon IC, Burley GA, Dominguez C
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AlignScape, displaying sequence similarity using self-organizing maps.
- Front Bioinform - published February 12, 2024
- Filella-Merce I, Mallet V, Durand E, Nilges M, Bouvier G, Pellarin R
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Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa.
- Nat Microbiol - published February 9, 2024
- Marmont LS, Orta AK, Baileeves BWA, Sychantha D, Fernández-Galliano A, Li YE, Greene NG, Corey RA, Stansfeld PJ, Clemons WM Jr, Bernhardt TG
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Snowprint: a predictive tool for genetic biosensor discovery.
- Commun Biol - published February 9, 2024
- d'Oelsnitz S, Stofel SK, Love JD, Ellington AD
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Structural basis for excitatory neuropeptide signaling.
- Nat Struct Mol Biol - published February 9, 2024
- Kalienkova V, Dandamudi M, Paulino C, Lynagh T
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Mosaic sarbecovirus vaccination elicits cross-reactive responses in pre-immunized animals.
- bioRxiv - published February 9, 2024
- Cohen AA, Keeffe JR, Schiepers A, Dross SE, Greaney AJ, Rorick AV, Gao H, Gnanapragasam PNP, Fan C, West AP Jr, Ramsingh AI, Erasmus JH, Pata JD, Muramatsu H, Pardi N, Lin PJC, Baxter S, Cruz R, Quintanar-Audelo M, Robb E, Serrano-Amatriain C, Magneschi L, Fotheringham IG, Fuller DH, Victora GD, Bjorkman PJ
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Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase.
- J Med Chem - published February 8, 2024
- Maw JJ, Coker JA, Arya T, Goins CM, Sonawane D, Han SH, Rees MG, Ronan MM, Roth JA, Wang NS, Heemers HV, Macdonald JD, Stauffer SR
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Chromatin binding by HORMAD proteins regulates meiotic recombination initiation.
- EMBO J - published February 8, 2024
- Milano CR, Ur SN, Gu Y, Zhang J, Allison R, Brown G, Neale MJ, Tromer EC, Corbett KD, Hochwagen A
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Encoding scheme design for gradient-free, nonlinear projection imaging using Bloch-Siegert RF spatial encoding in a low-field, open MRI system.
- Sci Rep - published February 8, 2024
- Selvaganesan K, Ha Y, Sun H, Zhang Z, Sun C, Samardzija A, Galiana G, Constable RT
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Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3(KBTBD2).
- Nat Struct Mol Biol - published February 8, 2024
- Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
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Harmonizing the Generation and Pre-publication Stewardship of FAIR Image data.
- ArXiv - published February 8, 2024
- Bialy N, Alber F, Andrews B, Angelo M, Beliveau B, Bintu L, Boettiger A, Boehm U, Brown CM, Maina MB, Chambers JJ, Cimini BA, Eliceiri K, Errington R, Faklaris O, Gaudreault N, Germain RN, Goscinski W, Grunwald D, Halter M, Hanein D, Hickey JW, Lacoste J, Laude A, Lundberg E, Ma J, Malacrida L, Moore J, Nelson G, Neumann EK, Nitschke R, Onami S, Pimentel JA, Plant AL, Radtke AJ, Sabata B, Schapiro D, Schöneberg J, Spraggins JM, Sudar D, Adrien Maria Vierdag WM, Volkmann N, Wählby C, Wang SS, Yaniv Z, Strambio-De-Castillia C
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Microstructure and Friction Properties of AlCrTiVNb(x) High-Entropy Alloys via Annealing Manufactured by Vacuum Arc Melting.
- Materials (Basel) - published February 8, 2024
- Li B, Zhang Z, Luo X, Chen K, Zhang J, Gong P, Peng Z
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GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
- Nat Struct Mol Biol - published February 7, 2024
- Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter JF, Dror RO, Evers AS, Mukhopadhyay S, Manglik A
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Allosteric modulation and G-protein selectivity of the Ca(2+)-sensing receptor.
- Nature - published February 7, 2024
- He F, Wu CG, Gao Y, Rahman SN, Zaoralová M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
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Primary care indicators for disease burden, monitoring and surveillance of COVID-19 in 31 European countries: Eurodata Study.
- Eur J Public Health - published February 7, 2024
- Ares-Blanco S, Guisado-Clavero M, Del Rio LR, Larrondo IG, Fitzgerald L, Murauskienė L, López NP, Perjés Á, Petek D, Petrazzuoli F, Petricek G, Sattler M, Saurek-Aleksandrovska N, Senn O, Seifert B, Serafini A, Sentker T, Ticmane G, Tiili P, Torzsa P, Valtonen K, Vaes B, Vinker S, Adler L, Assenova R, Bakola M, Bayen S, Brutskaya-Stempkovskaya E, Busneag IC, Divjak AĆ, Peña MD, Díaz E, Domeyer PR, Feldmane S, Gjorgjievski D, Gómez-Johansson M, de la Fuente ÁG, Hanževački M, Hoffmann K, Ільков О, Ivanna S, Jandrić-Kočić M, Karathanos VT, Üçüncü EK, Kirkovski A, Knežević S, Korkmaz BÇ, Kostić M, Krztoń-Królewiecka A, Kozlovska L, Nessler K, Gómez-Bravo R, Peña MPA, Lingner H
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Stabilization of a Cu-binding site by a highly conserved tryptophan residue.
- J Inorg Biochem - published February 7, 2024
- de Oliveira Silva YR, Zheng D, Peters SC, Fisher OS
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Systematic analysis of nonprogrammed frameshift suppression in E. coli via translational tiling proteomics.
- Proc Natl Acad Sci U S A - published February 6, 2024
- Springstein BL, Paulo JA, Park H, Henry K, Fleming E, Feder Z, Harper JW, Hochschild A
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A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions.
- Proc Natl Acad Sci U S A - published February 6, 2024
- Li R, Zan Y, Wang D, Chen X, Wang A, Tan H, Zhang G, Ding S, Shen C, Wu H, Zhu S
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Malignant tumor cells engender second membrane-lined organelles for self-protection and tumor progression.
- Proc Natl Acad Sci U S A - published February 6, 2024
- Yi T, Wagner G
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Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
- Proc Natl Acad Sci U S A - published February 6, 2024
- Schönherr H, Ayaz P, Taylor AM, Casaletto JB, Touré BB, Moustakas DT, Hudson BM, Valverde R, Zhao S, O'Hearn PJ, Foster L, Sharon DA, Garfinkle S, Giordanetto F, Lescarbeau A, Kurukulasuriya R, Gerami-Moayed N, Maglic D, Bruderek K, Naik G, Gunaydin H, Mader MM, Boezio AA, McLean TH, Chen R, Wang Y, Shaw DE, Watters J, Bergstrom DA
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E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration.
- Sci Rep - published February 6, 2024
- Zegeye Y, Aredo B, Yuksel S, Kirman DC, Kumar A, Chen B, Turpin E, Shresta S, He YG, Gautron L, Tang M, Li X, DiCesare SM, Hulleman JD, Xing C, Ludwig S, Moresco EMY, Beutler BA, Ufret-Vincenty RL
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MAIVeSS: streamlined selection of antigenically matched, high-yield viruses for seasonal influenza vaccine production.
- Nat Commun - published February 6, 2024
- Gao C, Wen F, Guan M, Hatuwal B, Li L, Praena B, Tang CY, Zhang J, Luo F, Xie H, Webby R, Tao YJ, Wan XF
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A non-human primate model for human norovirus infection.
- Nat Microbiol - published February 6, 2024
- Rimkute I, Chaimongkol N, Woods KD, Nagata BM, Darko S, Gudbole S, Henry AR, Sosnovtsev SV, Olia AS, Verardi R, Bok K, Todd JP, Woodward R, Kwong PD, Douek DC, Alves DA, Green KY, Roederer M
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Plastid ancestors lacked a complete Entner-Doudoroff pathway, limiting plants to glycolysis and the pentose phosphate pathway.
- Nat Commun - published February 6, 2024
- Evans SE, Franks AE, Bergman ME, Sethna NS, Currie MA, Phillips MA
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Cross comparison representation learning for semi-supervised segmentation of cellular nuclei in immunofluorescence staining.
- Comput Biol Med - published February 6, 2024
- Ren J, Che J, Gong P, Wang X, Li X, Li A, Xiao C
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Stepwise assembly and release of Tc toxins from Yersinia entomophaga.
- Nat Microbiol - published February 5, 2024
- Feldmüller M, Ericson CF, Afanasyev P, Lien YW, Weiss GL, Wollweber F, Schoof M, Hurst M, Pilhofer M
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Signaling from RAS to RAF: The Molecules and Their Mechanisms.
- Annu Rev Biochem - published February 5, 2024
- Jeon H, Tkacik E, Eck MJ
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Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets.
- Front Cell Neurosci - published February 5, 2024
- Watts ME, Giadone RM, Ordureau A, Holton KM, Harper JW, Rubin LL
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Studying Conformational Properties of Transmembrane Domain of KCNE3 in a Lipid Bilayer Membrane Using Molecular Dynamics Simulations.
- Membranes (Basel) - published February 4, 2024
- Moura ACM, Asare IK, Cruz MF, Aguado AJF, Tuck KD, Campbell CC, Scheyer MW, Obaseki I, Alston S, Kravats AN, Sanders CR, Lorigan GA, Sahu ID
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Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections.
- J Med Chem - published February 3, 2024
- Maddirala AR, Pinkner JS, Tamadonfar K, Sanick D, Hultgren SJ, Janetka JW
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An enhanced broad-spectrum peptide inhibits Omicron variants in vivo.
- Cell Rep Med - published February 3, 2024
- Bi W, Tang K, Chen G, Xie Y, Polizzi NF, DeGrado WF, Yuan S, Dang B
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The co-receptor Tspan12 directly captures Norrin to promote ligand-specific β-catenin signaling.
- bioRxiv - published February 3, 2024
- Bruguera ES, Mahoney JP, Weis WI
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A multiprotein signaling complex sustains AKT and mTOR/S6K activity necessary for the survival of cancer cells undergoing stress.
- bioRxiv - published February 2, 2024
- Pumar OYT, Zanotelli MR, Lin MJ, Schmitt RR, Green KS, Rojas KS, Hwang IY, Cerione RA, Wilson KF
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Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy.
- Sci Adv - published February 2, 2024
- Stanford SM, Nguyen TP, Chang J, Zhao Z, Hackman GL, Santelli E, Sanders CM, Katiki M, Dondossola E, Brauer BL, Diaz MA, Zhan Y, Ramsey SH, Watson PA, Sankaran B, Paindelli C, Parietti V, Mikos AG, Lodi A, Bagrodia A, Elliott A, McKay RR, Murali R, Tiziani S, Kettenbach AN, Bottini N
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Type III-B CRISPR-Cas cascade of proteolytic cleavages.
- Science - published February 2, 2024
- Steens JA, Bravo JPK, Salazar CRP, Yildiz C, Amieiro AM, Köstlbacher S, Prinsen SHP, Andres AS, Patinios C, Bardis A, Barendregt A, Scheltema RA, Ettema TJG, van der Oost J, Taylor DW, Staals RHJ
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Microsecond dynamics control the HIV-1 Envelope conformation.
- Sci Adv - published February 2, 2024
- Bennett AL, Edwards R, Kosheleva I, Saunders C, Bililign Y, Williams A, Bubphamala P, Manosouri K, Anasti K, Saunders KO, Alam SM, Haynes BF, Acharya P, Henderson R
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Characterization of an Acinetobacter baumannii Monofunctional Phosphomethylpyrimidine Kinase That Is Inhibited by Pyridoxal Phosphate.
- Biochemistry - published February 2, 2024
- De Vitto H, Belfon KKJ, Sharma N, Toay S, Abendroth J, Dranow DM, Lukacs CM, Choi R, Udell HS, Willis S, Barrera G, Beyer O, Li TD, Hicks KA, Torelli AT, French JB
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Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4.
- Nat Chem Biol - published February 2, 2024
- Zhou X, Kong S, Maker A, Remesh SG, Leung KK, Verba KA, Wells JA
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Factors governing the transcriptome changes and chronological lifespan of fission yeast during phosphate starvation.
- J Biol Chem - published February 2, 2024
- Garg A, Sanchez AM, Schwer B, Shuman S
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Deep learning assisted single particle tracking for automated correlation between diffusion and function.
- Res Sq - published February 2, 2024
- Kæstel-Hansen J, de Sautu M, Saminathan A, Scanavachi G, Da Cunha Correia RFB, Nielsen AJ, Bleshøy SV, Boomsma W, Kirchhausen T, Hatzakis NS
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Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity.
- mBio - published February 2, 2024
- Wang Y, Hollingsworth LR, Sangaré LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ
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Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
- Nat Commun - published February 2, 2024
- Martinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Zihsler S, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF
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Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.
- Commun Chem - published February 2, 2024
- Wittlinger F, Ogboo BC, Shevchenko E, Damghani T, Pham CD, Schaeffner IK, Oligny BT, Chitnis SP, Beyett TS, Rasch A, Buckley B, Urul DA, Shaurova T, May EW, Schaefer EM, Eck MJ, Hershberger PA, Poso A, Laufer SA, Heppner DE
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Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge.
- Nat Commun - published February 2, 2024
- Hsieh CL, Leist SR, Miller EH, Zhou L, Powers JM, Tse AL, Wang A, West A, Zweigart MR, Schisler JC, Jangra RK, Chandran K, Baric RS, McLellan JS
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Structural identification of a selectivity filter in CFTR.
- Proc Natl Acad Sci U S A - published February 2, 2024
- Levring J, Chen J
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Asparagine-85 Stabilizes a Structural Active Site Water Network in CYP121A1 of Mycobacterium tuberculosis.
- Biochemistry - published February 2, 2024
- Campomizzi CS, Uttamrao PP, Stallone JJ, Rathinavelan T, Estrada DF
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Tepsin binds LC3B to promote ATG9A trafficking and delivery.
- Mol Biol Cell - published February 2, 2024
- Wallace NS, Gadbery JE, Cohen CI, Kendall AK, Jackson LP
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Polymorphic Structure Determination of the Macrocyclic Drug Paritaprevir by MicroED.
- Adv Biol (Weinh) - published February 2, 2024
- Bu G, Danelius E, Wieske LHE, Gonen T
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UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
- Nature - published February 2, 2024
- DaRosa PA, Penchev I, Gumbin SC, Scavone F, Wąchalska M, Paulo JA, Ordureau A, Peter JJ, Kulathu Y, Harper JW, Becker T, Beckmann R, Kopito RR
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Biosynthesis of Cytidine Diphosphate-6-d-Glucitol for the Capsular Polysaccharides of Campylobacter jejuni.
- Biochemistry - published February 2, 2024
- Ghosh MK, Narindoshvili T, Thoden JB, Schumann ME, Holden HM, Raushel FM
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The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
- Nat Struct Mol Biol - published February 2, 2024
- Maisonneuve P, Sahmi M, Bergeron-Labrecque F, Ma XI, Queguiner J, Arseneault G, Lefrançois M, Kurinov I, Fronzes R, Sicheri F, Therrien M
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Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress.
- mBio - published February 2, 2024
- Martinez M, Bouillon A, Brûlé S, Raynal B, Haouz A, Alzari PM, Barale J-C
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Generation of site-specifically labelled fluorescent human XPA to investigate DNA binding dynamics during nucleotide excision repair.
- Methods - published February 2, 2024
- Kuppa S, Corless E, Caldwell C, Spies M, Antony E
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Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators.
- RSC Med Chem - published February 2, 2024
- Liu Y, Nowak RP, Che J, Donovan KA, Huerta F, Liu H, Metivier RJ, Fischer ES, Jones LH
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Mesothelin CAR T-cells secreting anti-FAP/anti-CD3 molecules efficiently target pancreatic adenocarcinoma and its stroma.
- Clin Cancer Res - published February 2, 2024
- Wehrli M, Guinn S, Birocchi F, Kuo A, Sun Y, Larson RC, Almazan AJ, Scarfò I, Bouffard AA, Bailey SR, Anekal PV, Montero Lopis P, Nieman LT, Song Y, Xu KH, Berger TR, Kann MC, Leick MB, Silva H, Salas-Benito D, Kienka T, Grauwet K, Armstrong TD, Zhang R, Zhu Q, Fu J, Schmidts A, Korell F, Jan M, Choi BD, Liss AS, Boland GM, Ting DT, Burkhart RA, Jenkins RW, Zheng L, Jaffee EM, Zimmerman JW, Maus MV
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CD38-directed, single-chain T cell-engager targets leukemia stem cells through IFNγ-induced CD38 expression.
- Blood - published February 2, 2024
- Murtadha M, Park M, Zhu Y, Caserta E, Napolitano O, Tandoh T, Moloudizargari M, Pozhitkov A, Singer MK, Dona AA, Vahed H, Gonzalez A, Ly K, Ouyang C, Sanchez J, Nigam L, Duplan A, Chowdhury A, Ghoda LY, Li L, Zhang B, Krishnan AY, Marcucci G, Williams JC, Pichiorri F
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Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation.
- Mol Cell - published February 2, 2024
- Li H, Ji Z, Paulo JA, Gygi SP, Rapoport TA
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Enzyme Kinetics Analysis: An online tool for analyzing enzyme initial rate data and teaching enzyme kinetics.
- Biochem Mol Biol Educ - published February 2, 2024
- Mak DA, Dunn S, Coombes D, Carere CR, Allison JR, Nock V, Hudson AO, Dobson RCJ
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Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
- Nat Cell Biol - published February 2, 2024
- F De Jesus D, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN
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The open gate of the AMPA receptor forms a Ca(2+) binding site critical in regulating ion transport.
- Nat Struct Mol Biol - published February 2, 2024
- Nakagawa T, Wang XT, Miguez-Cabello FJ, Bowie D
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A release of local subunit conformational heterogeneity underlies gating in a muscle nicotinic acetylcholine receptor.
- Nat Commun - published February 2, 2024
- Thompson MJ, Mansoub Bekarkhanechi F, Ananchenko A, Nury H, Baenziger JE
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Biochemical and Structural Studies of the Carminomycin 4-O-Methyltransferase DnrK.
- J Nat Prod - published February 2, 2024
- Jalali E, Wang F, Overbay BR, Miller MD, Shaaban KA, Ponomareva LV, Ye Q, Saghaeiannejad-Esfahani H, Bhardwaj M, Steele AD, Teijaro CN, Shen B, Van Lanen SG, She QB, Voss SR, Phillips GN Jr, Thorson JS
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Replication Bypass of the N-(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase η.
- Biochemistry - published February 2, 2024
- Tomar R, Li S, Egli M, Stone MP
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Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation.
- Sci Signal - published February 2, 2024
- Erickson EC, You I, Perry G, Dugourd A, Donovan KA, Crafter C, Johannes JW, Williamson S, Moss JI, Ros S, Ziegler RE, Barry ST, Fischer ES, Gray NS, Madsen RR, Toker A
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CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells.
- mBio - published February 2, 2024
- Rathore U, Haas P, Easwar Kumar V, Hiatt J, Haas KM, Bouhaddou M, Swaney DL, Stevenson E, Zuliani-Alvarez L, McGregor MJ, Turner-Groth A, Ochieng' Olwal C, Bediako Y, Braberg H, Soucheray M, Ott M, Eckhardt M, Hultquist JF, Marson A, Kaake RM, Krogan NJ
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Deficiency in PHD2-mediated hydroxylation of HIF2α underlies Pacak-Zhuang syndrome.
- Commun Biol - published February 2, 2024
- Ferens FG, Taber CC, Stuart S, Hubert M, Tarade D, Lee JE, Ohh M
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Author Correction: Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish.
- Commun Biol - published February 2, 2024
- Lawir DF, Soza-Ried C, Iwanami N, Siamishi I, Bylund GO, O Meara C, Sikora K, Kanzler B, Johansson E, Schorpp M, Cauchy P, Boehm T
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In situ analysis of osmolyte mechanisms of proteome thermal stabilization.
- Nat Chem Biol - published February 2, 2024
- Pepelnjak M, Velten B, Näpflin N, von Rosen T, Palmiero UC, Ko JH, Maynard HD, Arosio P, Weber-Ban E, de Souza N, Huber W, Picotti P
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CAMSAPs and nucleation-promoting factors control microtubule release from γ-TuRC.
- Nat Cell Biol - published February 2, 2024
- Rai D, Song Y, Hua S, Stecker K, Monster JL, Yin V, Stucchi R, Xu Y, Zhang Y, Chen F, Katrukha EA, Altelaar M, Heck AJR, Wieczorek M, Jiang K, Akhmanova A
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Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets.
- Nat Rev Cancer - published February 2, 2024
- Tate EW, Soday L, de la Lastra AL, Wang M, Lin H
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Considerations for developing mitochondrial transplantation techniques for individualized medicine.
- Biotechniques - published February 2, 2024
- Neikirk K, Stephens DC, Beasley HK, Marshall AG, Gaddy JA, Damo SM, Hinton AO Jr
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Proteolysis Targeting Chimera Degraders of the METTL3-14 m(6)A-RNA Methyltransferase.
- JACS Au - published February 2, 2024
- Errani F, Invernizzi A, Herok M, Bochenkova E, Stamm F, Corbeski I, Romanucci V, Di Fabio G, Zálešák F, Caflisch A
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Past, present, and future of CRISPR genome editing technologies.
- Cell - published February 2, 2024
- Pacesa M, Pelea O, Jinek M
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A cryptic plasmid is among the most numerous genetic elements in the human gut.
- Cell - published February 2, 2024
- Fogarty EC, Schechter MS, Lolans K, Sheahan ML, Veseli I, Moore RM, Kiefl E, Moody T, Rice PA, Yu MK, Mimee M, Chang EB, Ruscheweyh HJ, Sunagawa S, Mclellan SL, Willis AD, Comstock LE, Eren AM
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Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase.
- Immunity - published February 2, 2024
- Lederhofer J, Tsybovsky Y, Nguyen L, Raab JE, Creanga A, Stephens T, Gillespie RA, Syeda HZ, Fisher BE, Skertic M, Yap C, Schaub AJ, Rawi R, Kwong PD, Graham BS, McDermott AB, Andrews SF, King NP, Kanekiyo M
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Miffi: Improving the accuracy of CNN-based cryo-EM micrograph filtering with fine-tuning and Fourier space information.
- J Struct Biol - published February 2, 2024
- Xu D, Ando N
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Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
- Eur J Med Chem - published February 2, 2024
- Amblard F, LeCher JC, De R, Zhou S, Liu P, Goh SL, Tao S, Patel D, Downs-Bowen J, Zandi K, Zhang H, Chaudhry G, McBrayer T, Muczynski M, Al-Homoudi A, Engel J, Lan S, Sarafianos SG, Kovari LC, Schinazi RF
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Zebrafish and cellular models of SELENON-Related Myopathy exhibit novel embryonic and metabolic phenotypes.
- bioRxiv - published February 2, 2024
- Barraza-Flores P, Moghadaszadeh B, Lee W, Isaac B, Sun L, Troiano EC, Rockowitz S, Sliz P, Beggs AH
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Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pan-genome hybrid selection.
- bioRxiv - published February 2, 2024
- Young MG, Straub TJ, Worby CJ, Metsky HC, Gnirke A, Bronson RA, van Dijk LR, Desjardins CA, Matranga C, Qu J, Dodson K, Schreiber HL 4th, Manson AL, Hultgren SJ, Earl AM
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Astrocyte morphogenesis requires self-recognition.
- Res Sq - published February 2, 2024
- Zipursky S, Lee J, Sergeeva A, Ahlsen G, Mannepalli S, Bahna F, Goodman K, Khakh B, Weiner J, Shapiro L, Honig B
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β-amino acids reduce ternary complex stability and alter the translation elongation mechanism.
- bioRxiv - published February 2, 2024
- Cruz-Navarrete FA, Griffin WC, Chan YC, Martin MI, Alejo JL, Natchiar SK, Knudson IJ, Altman RB, Schepartz A, Miller SJ, Blanchard SC
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Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast.
- bioRxiv - published February 2, 2024
- Barrero DJ, Wijeratne SS, Zhao X, Cunningham GF, Rui Y, Nelson CR, Yasuhiro A, Funabiki H, Asbury CL, Yu Z, Subramanian R, Biggins S
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Divergent Folding-Mediated Epistasis Among Unstable Membrane Protein Variants.
- bioRxiv - published February 1, 2024
- Chamness LM, Kuntz CP, McKee AG, Penn WD, Hemmerich CM, Rusch DB, Woods H, Dyotima, Meiler J, Schlebach JP
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The cryo-EM structure of the BoNT/Wo-NTNH complex reveals two immunoglobulin-like domains.
- FEBS J - published February 1, 2024
- Košenina S, Škerlová J, Zhang S, Dong M, Stenmark P
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Crystal structure of the RNA-recognition motif of Drosophila melanogaster tRNA (uracil-5-)-methyltransferase homolog A.
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Deciphering the crystal structure of a novel nanobody against the NEIL1 DNA glycosylase.
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Genetic influences on motor learning and performance and superperforming mutants revealed by random mutational survey of the mouse genome.
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ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases.
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Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity.
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Structure is beauty, but not always truth.
- Cell - published February 1, 2024
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Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD(7).
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Tracing the evolutionary origins of antiviral immunity.
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Long trimer-immunization interval and appropriate adjuvant reduce immune responses to the soluble HIV-1-envelope trimer base.
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Dynamic nucleolar phase separation influenced by non-canonical function of LIN28A instructs pluripotent stem cell fate decisions.
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Matrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions.
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Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine.
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A Berlin-sided retrospective of the origins of metabolic control theory.
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CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
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Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter.
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A distinctive family of L,D-transpeptidases catalyzing L-Ala-mDAP crosslinks in Alpha- and Betaproteobacteria.
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An intramolecular macrocyclase in plant ribosomal peptide biosynthesis.
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Author Correction: Structural basis of pH-dependent activation in a CLC transporter.
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Ultrastructure of macromolecular assemblies contributing to bacterial spore resistance revealed by in situ cryo-electron tomography.
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Corrigendum to "Cross-species analysis of transcriptome emphasizes a critical role of TNF-α in mediating MAP2K7/AKT2 signaling in zearalenone-induced apoptosis" [J Hazard Mater 459 (2023) 132226].
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Influence of pump laser fluence on ultrafast myoglobin structural dynamics.
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Immune Profiling of Dermatologic Adverse Events from Checkpoint Blockade using Tissue Cyclic Immunofluorescence: A Pilot Study.
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TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer.
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Telomerase misbehaves after a breakup.
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Publisher Correction: A non-human primate model for human norovirus infection.
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Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B Cells.
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Computational drug development for membrane protein targets.
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Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail.
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Breaking the K48-chain: linking ubiquitin beyond protein degradation.
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An alpha-helical lid guides the target DNA toward catalysis in CRISPR-Cas12a.
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A left-handed RNA quadruplex directs gene silencing.
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Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA.
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Small LEA proteins as an effective air-water interface protectant for fragile samples during cryo-EM grid plunge freezing.
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Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications.
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Phospho-KNL-1 recognition by a TPR domain targets the BUB-1-BUB-3 complex to C. elegans kinetochores.
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Mechanistic insights from inflammasome structures.
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Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Subvariant Neutralization Following a Primary Vaccine Series of NVX-CoV2373 and BNT162b2 Monovalent Booster Vaccine.
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Miffi: Improving the accuracy of CNN-based cryo-EM micrograph filtering with fine-tuning and Fourier space information.
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Structural insights into IMP2 dimerization and RNA binding.
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Loop extrusion-mediated plasmid DNA cleavage by the bacterial SMC Wadjet complex.
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Advanced Surface Passivation for High-Sensitivity Studies of Biomolecular Condensates.
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A systematic quantitative approach comprehensively defines domain-specific functional pathways linked to Schizosaccharomyces pombe heterochromatin regulation.
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Ability of dynamic gadoxetic acid-enhanced magnetic resonance imaging combined with water-specific T1 mapping to reflect inflammation in a rat model of early-stage nonalcoholic steatohepatitis.
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Ion and lipid orchestration of secondary active transport.
- Nature - published February 1, 2024
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Recommendations for accelerating open preprint peer review to improve the culture of science.
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