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131 Member Publications for February 2024

Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation.
1. Cell - published February 29, 2024
2. Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM, Cecchini M, Hibbs RE
2'-(19)F labelling of ribose in RNAs: a tool to analyse RNA/protein interactions by NMR in physiological conditions.
1. Front Mol Biosci - published February 29, 2024
2. Kara H, Axer A, Muskett FW, Bueno-Alejo CJ, Paschalis V, Taladriz-Sender A, Tubasum S, Vega MS, Zhao Z, Clark AW, Hudson AJ, Eperon IC, Burley GA, Dominguez C
AlignScape, displaying sequence similarity using self-organizing maps.
1. Front Bioinform - published February 12, 2024
2. Filella-Merce I, Mallet V, Durand E, Nilges M, Bouvier G, Pellarin R
Snowprint: a predictive tool for genetic biosensor discovery.
1. Commun Biol - published February 9, 2024
2. d'Oelsnitz S, Stofel SK, Love JD, Ellington AD
Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa.
1. Nat Microbiol - published February 9, 2024
2. Marmont LS, Orta AK, Baileeves BWA, Sychantha D, Fernández-Galliano A, Li YE, Greene NG, Corey RA, Stansfeld PJ, Clemons WM Jr, Bernhardt TG
Structural basis for excitatory neuropeptide signaling.
1. Nat Struct Mol Biol - published February 9, 2024
2. Kalienkova V, Dandamudi M, Paulino C, Lynagh T
Mosaic sarbecovirus vaccination elicits cross-reactive responses in pre-immunized animals.
1. bioRxiv - published February 9, 2024
2. Cohen AA, Keeffe JR, Schiepers A, Dross SE, Greaney AJ, Rorick AV, Gao H, Gnanapragasam PNP, Fan C, West AP Jr, Ramsingh AI, Erasmus JH, Pata JD, Muramatsu H, Pardi N, Lin PJC, Baxter S, Cruz R, Quintanar-Audelo M, Robb E, Serrano-Amatriain C, Magneschi L, Fotheringham IG, Fuller DH, Victora GD, Bjorkman PJ
Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase.
1. J Med Chem - published February 8, 2024
2. Maw JJ, Coker JA, Arya T, Goins CM, Sonawane D, Han SH, Rees MG, Ronan MM, Roth JA, Wang NS, Heemers HV, Macdonald JD, Stauffer SR
Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3(KBTBD2).
1. Nat Struct Mol Biol - published February 8, 2024
2. Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Encoding scheme design for gradient-free, nonlinear projection imaging using Bloch-Siegert RF spatial encoding in a low-field, open MRI system.
1. Sci Rep - published February 8, 2024
2. Selvaganesan K, Ha Y, Sun H, Zhang Z, Sun C, Samardzija A, Galiana G, Constable RT
Chromatin binding by HORMAD proteins regulates meiotic recombination initiation.
1. EMBO J - published February 8, 2024
2. Milano CR, Ur SN, Gu Y, Zhang J, Allison R, Brown G, Neale MJ, Tromer EC, Corbett KD, Hochwagen A
Harmonizing the Generation and Pre-publication Stewardship of FAIR Image data.
1. ArXiv - published February 8, 2024
2. Bialy N, Alber F, Andrews B, Angelo M, Beliveau B, Bintu L, Boettiger A, Boehm U, Brown CM, Maina MB, Chambers JJ, Cimini BA, Eliceiri K, Errington R, Faklaris O, Gaudreault N, Germain RN, Goscinski W, Grunwald D, Halter M, Hanein D, Hickey JW, Lacoste J, Laude A, Lundberg E, Ma J, Malacrida L, Moore J, Nelson G, Neumann EK, Nitschke R, Onami S, Pimentel JA, Plant AL, Radtke AJ, Sabata B, Schapiro D, Schöneberg J, Spraggins JM, Sudar D, Adrien Maria Vierdag WM, Volkmann N, Wählby C, Wang SS, Yaniv Z, Strambio-De-Castillia C
Microstructure and Friction Properties of AlCrTiVNb(x) High-Entropy Alloys via Annealing Manufactured by Vacuum Arc Melting.
1. Materials (Basel) - published February 8, 2024
2. Li B, Zhang Z, Luo X, Chen K, Zhang J, Gong P, Peng Z
Allosteric modulation and G-protein selectivity of the Ca(2+)-sensing receptor.
1. Nature - published February 7, 2024
2. He F, Wu CG, Gao Y, Rahman SN, Zaoralová M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
1. Nat Struct Mol Biol - published February 7, 2024
2. Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter JF, Dror RO, Evers AS, Mukhopadhyay S, Manglik A
Primary care indicators for disease burden, monitoring and surveillance of COVID-19 in 31 European countries: Eurodata Study.
1. Eur J Public Health - published February 7, 2024
2. Ares-Blanco S, Guisado-Clavero M, Del Rio LR, Larrondo IG, Fitzgerald L, Murauskienė L, López NP, Perjés Á, Petek D, Petrazzuoli F, Petricek G, Sattler M, Saurek-Aleksandrovska N, Senn O, Seifert B, Serafini A, Sentker T, Ticmane G, Tiili P, Torzsa P, Valtonen K, Vaes B, Vinker S, Adler L, Assenova R, Bakola M, Bayen S, Brutskaya-Stempkovskaya E, Busneag IC, Divjak AĆ, Peña MD, Díaz E, Domeyer PR, Feldmane S, Gjorgjievski D, Gómez-Johansson M, de la Fuente ÁG, Hanževački M, Hoffmann K, Ільков О, Ivanna S, Jandrić-Kočić M, Karathanos VT, Üçüncü EK, Kirkovski A, Knežević S, Korkmaz BÇ, Kostić M, Krztoń-Królewiecka A, Kozlovska L, Nessler K, Gómez-Bravo R, Peña MPA, Lingner H
Stabilization of a Cu-binding site by a highly conserved tryptophan residue.
1. J Inorg Biochem - published February 7, 2024
2. de Oliveira Silva YR, Zheng D, Peters SC, Fisher OS
Systematic analysis of nonprogrammed frameshift suppression in E. coli via translational tiling proteomics.
1. Proc Natl Acad Sci U S A - published February 6, 2024
2. Springstein BL, Paulo JA, Park H, Henry K, Fleming E, Feder Z, Harper JW, Hochschild A
A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions.
1. Proc Natl Acad Sci U S A - published February 6, 2024
2. Li R, Zan Y, Wang D, Chen X, Wang A, Tan H, Zhang G, Ding S, Shen C, Wu H, Zhu S
Malignant tumor cells engender second membrane-lined organelles for self-protection and tumor progression.
1. Proc Natl Acad Sci U S A - published February 6, 2024
2. Yi T, Wagner G
Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
1. Proc Natl Acad Sci U S A - published February 6, 2024
2. Schönherr H, Ayaz P, Taylor AM, Casaletto JB, Touré BB, Moustakas DT, Hudson BM, Valverde R, Zhao S, O'Hearn PJ, Foster L, Sharon DA, Garfinkle S, Giordanetto F, Lescarbeau A, Kurukulasuriya R, Gerami-Moayed N, Maglic D, Bruderek K, Naik G, Gunaydin H, Mader MM, Boezio AA, McLean TH, Chen R, Wang Y, Shaw DE, Watters J, Bergstrom DA
MAIVeSS: streamlined selection of antigenically matched, high-yield viruses for seasonal influenza vaccine production.
1. Nat Commun - published February 6, 2024
2. Gao C, Wen F, Guan M, Hatuwal B, Li L, Praena B, Tang CY, Zhang J, Luo F, Xie H, Webby R, Tao YJ, Wan XF
E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration.
1. Sci Rep - published February 6, 2024
2. Zegeye Y, Aredo B, Yuksel S, Kirman DC, Kumar A, Chen B, Turpin E, Shresta S, He YG, Gautron L, Tang M, Li X, DiCesare SM, Hulleman JD, Xing C, Ludwig S, Moresco EMY, Beutler BA, Ufret-Vincenty RL
Plastid ancestors lacked a complete Entner-Doudoroff pathway, limiting plants to glycolysis and the pentose phosphate pathway.
1. Nat Commun - published February 6, 2024
2. Evans SE, Franks AE, Bergman ME, Sethna NS, Currie MA, Phillips MA
A non-human primate model for human norovirus infection.
1. Nat Microbiol - published February 6, 2024
2. Rimkute I, Chaimongkol N, Woods KD, Nagata BM, Darko S, Gudbole S, Henry AR, Sosnovtsev SV, Olia AS, Verardi R, Bok K, Todd JP, Woodward R, Kwong PD, Douek DC, Alves DA, Green KY, Roederer M
Cross comparison representation learning for semi-supervised segmentation of cellular nuclei in immunofluorescence staining.
1. Comput Biol Med - published February 6, 2024
2. Ren J, Che J, Gong P, Wang X, Li X, Li A, Xiao C
Stepwise assembly and release of Tc toxins from Yersinia entomophaga.
1. Nat Microbiol - published February 5, 2024
2. Feldmüller M, Ericson CF, Afanasyev P, Lien YW, Weiss GL, Wollweber F, Schoof M, Hurst M, Pilhofer M
Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets.
1. Front Cell Neurosci - published February 5, 2024
2. Watts ME, Giadone RM, Ordureau A, Holton KM, Harper JW, Rubin LL
Signaling from RAS to RAF: The Molecules and Their Mechanisms.
1. Annu Rev Biochem - published February 5, 2024
2. Jeon H, Tkacik E, Eck MJ
Studying Conformational Properties of Transmembrane Domain of KCNE3 in a Lipid Bilayer Membrane Using Molecular Dynamics Simulations.
1. Membranes (Basel) - published February 4, 2024
2. Moura ACM, Asare IK, Cruz MF, Aguado AJF, Tuck KD, Campbell CC, Scheyer MW, Obaseki I, Alston S, Kravats AN, Sanders CR, Lorigan GA, Sahu ID
Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections.
1. J Med Chem - published February 3, 2024
2. Maddirala AR, Pinkner JS, Tamadonfar K, Sanick D, Hultgren SJ, Janetka JW
An enhanced broad-spectrum peptide inhibits Omicron variants in vivo.
1. Cell Rep Med - published February 3, 2024
2. Bi W, Tang K, Chen G, Xie Y, Polizzi NF, DeGrado WF, Yuan S, Dang B
The co-receptor Tspan12 directly captures Norrin to promote ligand-specific β-catenin signaling.
1. bioRxiv - published February 3, 2024
2. Bruguera ES, Mahoney JP, Weis WI
A multiprotein signaling complex sustains AKT and mTOR/S6K activity necessary for the survival of cancer cells undergoing stress.
1. bioRxiv - published February 2, 2024
2. Pumar OYT, Zanotelli MR, Lin MJ, Schmitt RR, Green KS, Rojas KS, Hwang IY, Cerione RA, Wilson KF
Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy.
1. Sci Adv - published February 2, 2024
2. Stanford SM, Nguyen TP, Chang J, Zhao Z, Hackman GL, Santelli E, Sanders CM, Katiki M, Dondossola E, Brauer BL, Diaz MA, Zhan Y, Ramsey SH, Watson PA, Sankaran B, Paindelli C, Parietti V, Mikos AG, Lodi A, Bagrodia A, Elliott A, McKay RR, Murali R, Tiziani S, Kettenbach AN, Bottini N
Type III-B CRISPR-Cas cascade of proteolytic cleavages.
1. Science - published February 2, 2024
2. Steens JA, Bravo JPK, Salazar CRP, Yildiz C, Amieiro AM, Köstlbacher S, Prinsen SHP, Andres AS, Patinios C, Bardis A, Barendregt A, Scheltema RA, Ettema TJG, van der Oost J, Taylor DW, Staals RHJ
Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4.
1. Nat Chem Biol - published February 2, 2024
2. Zhou X, Kong S, Maker A, Remesh SG, Leung KK, Verba KA, Wells JA
Microsecond dynamics control the HIV-1 Envelope conformation.
1. Sci Adv - published February 2, 2024
2. Bennett AL, Edwards R, Kosheleva I, Saunders C, Bililign Y, Williams A, Bubphamala P, Manosouri K, Anasti K, Saunders KO, Alam SM, Haynes BF, Acharya P, Henderson R
Characterization of an Acinetobacter baumannii Monofunctional Phosphomethylpyrimidine Kinase That Is Inhibited by Pyridoxal Phosphate.
1. Biochemistry - published February 2, 2024
2. De Vitto H, Belfon KKJ, Sharma N, Toay S, Abendroth J, Dranow DM, Lukacs CM, Choi R, Udell HS, Willis S, Barrera G, Beyer O, Li TD, Hicks KA, Torelli AT, French JB
Factors governing the transcriptome changes and chronological lifespan of fission yeast during phosphate starvation.
1. J Biol Chem - published February 2, 2024
2. Garg A, Sanchez AM, Schwer B, Shuman S
Deep learning assisted single particle tracking for automated correlation between diffusion and function.
1. Res Sq - published February 2, 2024
2. Kæstel-Hansen J, de Sautu M, Saminathan A, Scanavachi G, Da Cunha Correia RFB, Nielsen AJ, Bleshøy SV, Boomsma W, Kirchhausen T, Hatzakis NS
Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity.
1. mBio - published February 2, 2024
2. Wang Y, Hollingsworth LR, Sangaré LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
1. Nat Commun - published February 2, 2024
2. Martinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Zihsler S, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF
Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge.
1. Nat Commun - published February 2, 2024
2. Hsieh CL, Leist SR, Miller EH, Zhou L, Powers JM, Tse AL, Wang A, West A, Zweigart MR, Schisler JC, Jangra RK, Chandran K, Baric RS, McLellan JS
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.
1. Commun Chem - published February 2, 2024
2. Wittlinger F, Ogboo BC, Shevchenko E, Damghani T, Pham CD, Schaeffner IK, Oligny BT, Chitnis SP, Beyett TS, Rasch A, Buckley B, Urul DA, Shaurova T, May EW, Schaefer EM, Eck MJ, Hershberger PA, Poso A, Laufer SA, Heppner DE
Structural identification of a selectivity filter in CFTR.
1. Proc Natl Acad Sci U S A - published February 2, 2024
2. Levring J, Chen J
Asparagine-85 Stabilizes a Structural Active Site Water Network in CYP121A1 of Mycobacterium tuberculosis.
1. Biochemistry - published February 2, 2024
2. Campomizzi CS, Uttamrao PP, Stallone JJ, Rathinavelan T, Estrada DF
Tepsin binds LC3B to promote ATG9A trafficking and delivery.
1. Mol Biol Cell - published February 2, 2024
2. Wallace NS, Gadbery JE, Cohen CI, Kendall AK, Jackson LP
Polymorphic Structure Determination of the Macrocyclic Drug Paritaprevir by MicroED.
1. Adv Biol (Weinh) - published February 2, 2024
2. Bu G, Danelius E, Wieske LHE, Gonen T
UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
1. Nature - published February 2, 2024
2. DaRosa PA, Penchev I, Gumbin SC, Scavone F, Wąchalska M, Paulo JA, Ordureau A, Peter JJ, Kulathu Y, Harper JW, Becker T, Beckmann R, Kopito RR
Biosynthesis of Cytidine Diphosphate-6-d-Glucitol for the Capsular Polysaccharides of Campylobacter jejuni.
1. Biochemistry - published February 2, 2024
2. Ghosh MK, Narindoshvili T, Thoden JB, Schumann ME, Holden HM, Raushel FM
Generation of site-specifically labelled fluorescent human XPA to investigate DNA binding dynamics during nucleotide excision repair.
1. Methods - published February 2, 2024
2. Kuppa S, Corless E, Caldwell C, Spies M, Antony E
The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
1. Nat Struct Mol Biol - published February 2, 2024
2. Maisonneuve P, Sahmi M, Bergeron-Labrecque F, Ma XI, Queguiner J, Arseneault G, Lefrançois M, Kurinov I, Fronzes R, Sicheri F, Therrien M
Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress.
1. mBio - published February 2, 2024
2. Martinez M, Bouillon A, Brûlé S, Raynal B, Haouz A, Alzari PM, Barale J-C
Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators.
1. RSC Med Chem - published February 2, 2024
2. Liu Y, Nowak RP, Che J, Donovan KA, Huerta F, Liu H, Metivier RJ, Fischer ES, Jones LH
Mesothelin CAR T-cells secreting anti-FAP/anti-CD3 molecules efficiently target pancreatic adenocarcinoma and its stroma.
1. Clin Cancer Res - published February 2, 2024
2. Wehrli M, Guinn S, Birocchi F, Kuo A, Sun Y, Larson RC, Almazan AJ, Scarfò I, Bouffard AA, Bailey SR, Anekal PV, Montero Lopis P, Nieman LT, Song Y, Xu KH, Berger TR, Kann MC, Leick MB, Silva H, Salas-Benito D, Kienka T, Grauwet K, Armstrong TD, Zhang R, Zhu Q, Fu J, Schmidts A, Korell F, Jan M, Choi BD, Liss AS, Boland GM, Ting DT, Burkhart RA, Jenkins RW, Zheng L, Jaffee EM, Zimmerman JW, Maus MV
CD38-directed, single-chain T cell-engager targets leukemia stem cells through IFNγ-induced CD38 expression.
1. Blood - published February 2, 2024
2. Murtadha M, Park M, Zhu Y, Caserta E, Napolitano O, Tandoh T, Moloudizargari M, Pozhitkov A, Singer MK, Dona AA, Vahed H, Gonzalez A, Ly K, Ouyang C, Sanchez J, Nigam L, Duplan A, Chowdhury A, Ghoda LY, Li L, Zhang B, Krishnan AY, Marcucci G, Williams JC, Pichiorri F
Enzyme Kinetics Analysis: An online tool for analyzing enzyme initial rate data and teaching enzyme kinetics.
1. Biochem Mol Biol Educ - published February 2, 2024
2. Mak DA, Dunn S, Coombes D, Carere CR, Allison JR, Nock V, Hudson AO, Dobson RCJ
Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation.
1. Mol Cell - published February 2, 2024
2. Li H, Ji Z, Paulo JA, Gygi SP, Rapoport TA
Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
1. Nat Cell Biol - published February 2, 2024
2. F De Jesus D, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN
Replication Bypass of the N-(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase η.
1. Biochemistry - published February 2, 2024
2. Tomar R, Li S, Egli M, Stone MP
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation.
1. Sci Signal - published February 2, 2024
2. Erickson EC, You I, Perry G, Dugourd A, Donovan KA, Crafter C, Johannes JW, Williamson S, Moss JI, Ros S, Ziegler RE, Barry ST, Fischer ES, Gray NS, Madsen RR, Toker A
The open gate of the AMPA receptor forms a Ca(2+) binding site critical in regulating ion transport.
1. Nat Struct Mol Biol - published February 2, 2024
2. Nakagawa T, Wang XT, Miguez-Cabello FJ, Bowie D
CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells.
1. mBio - published February 2, 2024
2. Rathore U, Haas P, Easwar Kumar V, Hiatt J, Haas KM, Bouhaddou M, Swaney DL, Stevenson E, Zuliani-Alvarez L, McGregor MJ, Turner-Groth A, Ochieng' Olwal C, Bediako Y, Braberg H, Soucheray M, Ott M, Eckhardt M, Hultquist JF, Marson A, Kaake RM, Krogan NJ
A release of local subunit conformational heterogeneity underlies gating in a muscle nicotinic acetylcholine receptor.
1. Nat Commun - published February 2, 2024
2. Thompson MJ, Mansoub Bekarkhanechi F, Ananchenko A, Nury H, Baenziger JE
Biochemical and Structural Studies of the Carminomycin 4-O-Methyltransferase DnrK.
1. J Nat Prod - published February 2, 2024
2. Jalali E, Wang F, Overbay BR, Miller MD, Shaaban KA, Ponomareva LV, Ye Q, Saghaeiannejad-Esfahani H, Bhardwaj M, Steele AD, Teijaro CN, Shen B, Van Lanen SG, She QB, Voss SR, Phillips GN Jr, Thorson JS
Deficiency in PHD2-mediated hydroxylation of HIF2α underlies Pacak-Zhuang syndrome.
1. Commun Biol - published February 2, 2024
2. Ferens FG, Taber CC, Stuart S, Hubert M, Tarade D, Lee JE, Ohh M
Author Correction: Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish.
1. Commun Biol - published February 2, 2024
2. Lawir DF, Soza-Ried C, Iwanami N, Siamishi I, Bylund GO, O Meara C, Sikora K, Kanzler B, Johansson E, Schorpp M, Cauchy P, Boehm T
Considerations for developing mitochondrial transplantation techniques for individualized medicine.
1. Biotechniques - published February 2, 2024
2. Neikirk K, Stephens DC, Beasley HK, Marshall AG, Gaddy JA, Damo SM, Hinton AO Jr
Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets.
1. Nat Rev Cancer - published February 2, 2024
2. Tate EW, Soday L, de la Lastra AL, Wang M, Lin H
CAMSAPs and nucleation-promoting factors control microtubule release from γ-TuRC.
1. Nat Cell Biol - published February 2, 2024
2. Rai D, Song Y, Hua S, Stecker K, Monster JL, Yin V, Stucchi R, Xu Y, Zhang Y, Chen F, Katrukha EA, Altelaar M, Heck AJR, Wieczorek M, Jiang K, Akhmanova A
In situ analysis of osmolyte mechanisms of proteome thermal stabilization.
1. Nat Chem Biol - published February 2, 2024
2. Pepelnjak M, Velten B, Näpflin N, von Rosen T, Palmiero UC, Ko JH, Maynard HD, Arosio P, Weber-Ban E, de Souza N, Huber W, Picotti P
Proteolysis Targeting Chimera Degraders of the METTL3-14 m(6)A-RNA Methyltransferase.
1. JACS Au - published February 2, 2024
2. Errani F, Invernizzi A, Herok M, Bochenkova E, Stamm F, Corbeski I, Romanucci V, Di Fabio G, Zálešák F, Caflisch A
A cryptic plasmid is among the most numerous genetic elements in the human gut.
1. Cell - published February 2, 2024
2. Fogarty EC, Schechter MS, Lolans K, Sheahan ML, Veseli I, Moore RM, Kiefl E, Moody T, Rice PA, Yu MK, Mimee M, Chang EB, Ruscheweyh HJ, Sunagawa S, Mclellan SL, Willis AD, Comstock LE, Eren AM
Past, present, and future of CRISPR genome editing technologies.
1. Cell - published February 2, 2024
2. Pacesa M, Pelea O, Jinek M
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase.
1. Immunity - published February 2, 2024
2. Lederhofer J, Tsybovsky Y, Nguyen L, Raab JE, Creanga A, Stephens T, Gillespie RA, Syeda HZ, Fisher BE, Skertic M, Yap C, Schaub AJ, Rawi R, Kwong PD, Graham BS, McDermott AB, Andrews SF, King NP, Kanekiyo M
Miffi: Improving the accuracy of CNN-based cryo-EM micrograph filtering with fine-tuning and Fourier space information.
1. J Struct Biol - published February 2, 2024
2. Xu D, Ando N
Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
1. Eur J Med Chem - published February 2, 2024
2. Amblard F, LeCher JC, De R, Zhou S, Liu P, Goh SL, Tao S, Patel D, Downs-Bowen J, Zandi K, Zhang H, Chaudhry G, McBrayer T, Muczynski M, Al-Homoudi A, Engel J, Lan S, Sarafianos SG, Kovari LC, Schinazi RF
Zebrafish and cellular models of SELENON-Related Myopathy exhibit novel embryonic and metabolic phenotypes.
1. bioRxiv - published February 2, 2024
2. Barraza-Flores P, Moghadaszadeh B, Lee W, Isaac B, Sun L, Troiano EC, Rockowitz S, Sliz P, Beggs AH
Astrocyte morphogenesis requires self-recognition.
1. Res Sq - published February 2, 2024
2. Zipursky S, Lee J, Sergeeva A, Ahlsen G, Mannepalli S, Bahna F, Goodman K, Khakh B, Weiner J, Shapiro L, Honig B
Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pan-genome hybrid selection.
1. bioRxiv - published February 2, 2024
2. Young MG, Straub TJ, Worby CJ, Metsky HC, Gnirke A, Bronson RA, van Dijk LR, Desjardins CA, Matranga C, Qu J, Dodson K, Schreiber HL 4th, Manson AL, Hultgren SJ, Earl AM
β-amino acids reduce ternary complex stability and alter the translation elongation mechanism.
1. bioRxiv - published February 2, 2024
2. Cruz-Navarrete FA, Griffin WC, Chan YC, Martin MI, Alejo JL, Natchiar SK, Knudson IJ, Altman RB, Schepartz A, Miller SJ, Blanchard SC
Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast.
1. bioRxiv - published February 2, 2024
2. Barrero DJ, Wijeratne SS, Zhao X, Cunningham GF, Rui Y, Nelson CR, Yasuhiro A, Funabiki H, Asbury CL, Yu Z, Subramanian R, Biggins S
Divergent Folding-Mediated Epistasis Among Unstable Membrane Protein Variants.
1. bioRxiv - published February 1, 2024
2. Chamness LM, Kuntz CP, McKee AG, Penn WD, Hemmerich CM, Rusch DB, Woods H, Dyotima, Meiler J, Schlebach JP
The cryo-EM structure of the BoNT/Wo-NTNH complex reveals two immunoglobulin-like domains.
1. FEBS J - published February 1, 2024
2. Košenina S, Škerlová J, Zhang S, Dong M, Stenmark P
Crystal structure of the RNA-recognition motif of Drosophila melanogaster tRNA (uracil-5-)-methyltransferase homolog A.
1. Acta Crystallogr F Struct Biol Commun - published February 1, 2024
2. Witzenberger M, Janowski R, Niessing D
Deciphering the crystal structure of a novel nanobody against the NEIL1 DNA glycosylase.
1. Acta Crystallogr D Struct Biol - published February 1, 2024
2. Thompson MK, Sharma N, Thorn A, Prakash A
ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases.
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Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity.
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Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD(7).
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Tracing the evolutionary origins of antiviral immunity.
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Long trimer-immunization interval and appropriate adjuvant reduce immune responses to the soluble HIV-1-envelope trimer base.
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An intramolecular macrocyclase in plant ribosomal peptide biosynthesis.
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Publisher Correction: A non-human primate model for human norovirus infection.
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TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer.
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Immune Profiling of Dermatologic Adverse Events from Checkpoint Blockade using Tissue Cyclic Immunofluorescence: A Pilot Study.
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Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B Cells.
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Computational drug development for membrane protein targets.
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An alpha-helical lid guides the target DNA toward catalysis in CRISPR-Cas12a.
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Breaking the K48-chain: linking ubiquitin beyond protein degradation.
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1. bioRxiv - published February 1, 2024
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Advanced Surface Passivation for High-Sensitivity Studies of Biomolecular Condensates.
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A systematic quantitative approach comprehensively defines domain-specific functional pathways linked to Schizosaccharomyces pombe heterochromatin regulation.
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Ability of dynamic gadoxetic acid-enhanced magnetic resonance imaging combined with water-specific T1 mapping to reflect inflammation in a rat model of early-stage nonalcoholic steatohepatitis.
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1. Nature - published February 1, 2024
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