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157 Member Publications for January 2024

Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding.
1. Structure - published January 30, 2024
2. Knejski PP, Erramilli SK, Kossiakoff AA
Benchmarking AlphaMissense pathogenicity predictions against cystic fibrosis variants.
1. PLoS One - published January 25, 2024
2. McDonald EF, Oliver KE, Schlebach JP, Meiler J, Plate L
Daily positive and negative affect during the COVID-19 pandemic.
1. Front Psychol - published January 23, 2024
2. Ivcevic Z, Shen S, Lin S, Cheng D, Probasco R, Silbermann B, Zhang F, Lin X, Brackett M
Targeting ion channels with ultra-large library screening for hit discovery.
1. Front Mol Neurosci - published January 22, 2024
2. Melancon K, Pliushcheuskaya P, Meiler J, Künze G
Zinc acquisition and its contribution to Klebsiella pneumoniae virulence.
1. Front Cell Infect Microbiol - published January 22, 2024
2. Maunders EA, Giles MW, Ganio K, Cunningham BA, Bennett-Wood V, Cole GB, Ng D, Lai CC, Neville SL, Moraes TF, McDevitt CA, Tan A
The catalytic activity of microRNA Argonautes plays a modest role in microRNA star strand destabilization in C. elegans.
1. bioRxiv - published January 9, 2024
2. Kotagama K, Grimme AL, Braviner L, Yang B, Sakhawala RM, Yu G, Benner LK, Joshua-Tor L, McJunkin K
Distinct structural motifs are necessary for targeting and import of Tim17 in Trypanosoma brucei mitochondrion.
1. mSphere - published January 9, 2024
2. Darden C, Donkor JE, Korolkova O, Barozai MYK, Chaudhuri M
Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE.
1. Nat Commun - published January 9, 2024
2. Botsch JJ, Junker R, Sorgenfrei M, Ogger PP, Stier L, von Gronau S, Murray PJ, Seeger MA, Schulman BA, Bräuning B
SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity.
1. mBio - published January 9, 2024
2. Zhang F, Schmidt F, Muecksch F, Wang Z, Gazumyan A, Nussenzweig MC, Gaebler C, Caskey M, Hatziioannou T, Bieniasz PD
Overcoming resolution attenuation during tilted cryo-EM data collection.
1. Nat Commun - published January 9, 2024
2. Aiyer S, Baldwin PR, Tan SM, Shan Z, Oh J, Mehrani A, Bowman ME, Louie G, Passos DO, Đorđević-Marquardt S, Mietzsch M, Hull JA, Hoshika S, Barad BA, Grotjahn DA, McKenna R, Agbandje-McKenna M, Benner SA, Noel JAP, Wang D, Tan YZ, Lyumkis D
Author Correction: Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex.
1. Nat Struct Mol Biol - published January 9, 2024
2. Hayne CK, Butay KJU, Stewart ZD, Krahn JM, Perera L, Williams JG, Petrovitch RM, Deterding LJ, Matera AG, Borgnia MJ, Stanley RE
Author Correction: Identification of inhibitors targeting the energy-coupling factor (ECF) transporters.
1. Commun Biol - published January 9, 2024
2. Diamanti E, Souza PCT, Setyawati I, Bousis S, Monjas L, Swier LJYM, Shams A, Tsarenko A, Stanek WK, Jäger M, Marrink SJ, Slotboom DJ, Hirsch AKH
Coordinated inositide lipid-phosphatase activities of synaptojanin modulates actin cytoskeleton organization.
1. Adv Biol Regul - published January 9, 2024
2. Zhang T, Hale AT, Guo S, York JD
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism.
1. bioRxiv - published January 9, 2024
2. Rashan EH, Bartlett AK, Khana DB, Zhang J, Jain R, Smith AJ, Baker ZN, Cook T, Caldwell A, Chevalier AR, Pfleger BF, Yuan P, Amador-Noguez D, Simcox JA, Pagliarini DJ
Collagen and actin network mediate antiviral immunity against Orsay virus in C. elegans intestinal cells.
1. PLoS Pathog - published January 8, 2024
2. Zhou Y, Chen H, Zhong W, Tao YJ
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states.
1. Elife - published January 8, 2024
2. Lin DY, Kueffer LE, Juneja P, Wales TE, Engen JR, Andreotti AH
Docking for Molecules That Bind in a Symmetric Stack with SymDOCK.
1. J Chem Inf Model - published January 8, 2024
2. Smith MS, Knight IS, Kormos RC, Pepe JG, Kunach P, Diamond MI, Shahmoradian SH, Irwin JJ, DeGrado WF, Shoichet BK
HDAC6/aggresome processing pathway importance for inflammasome formation is context dependent.
1. J Biol Chem - published January 8, 2024
2. Wang L, Shi S, Unterreiner A, Kapetanovic R, Ghosh S, Sanchez J, Aslani S, Xiong Y, Hsu CL, Donovan KA, Farady CJ, Fischer ES, Bornancin F, Matthias P
Poly(ADP-ribosyl)ation enhances nucleosome dynamics and organizes DNA damage repair components within biomolecular condensates.
1. Mol Cell - published January 8, 2024
2. Nosella ML, Kim TH, Huang SK, Harkness RW, Goncalves M, Pan A, Tereshchenko M, Vahidi S, Rubinstein JL, Lee HO, Forman-Kay JD, Kay LE
Bioorthogonal click labeling of an amber-free HIV-1 provirus for in-virus single molecule imaging.
1. Cell Chem Biol - published January 8, 2024
2. Ao Y, Grover JR, Gifford L, Han Y, Zhong G, Katte R, Li W, Bhattacharjee R, Zhang B, Sauve S, Qin W, Ghimire D, Haque MA, Arthos J, Moradi M, Mothes W, Lemke EA, Kwong PD, Melikyan GB, Lu M
Mechanism of anion exchange and small-molecule inhibition of pendrin.
1. Nat Commun - published January 6, 2024
2. Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M
Peer Support to Promote Surgeon Well-being: The APSA Program Experience.
1. J Pediatr Surg - published January 6, 2024
2. Fall F, Hu YY, Walker S, Baertschiger R, Gaffar I, Saltzman D, Stylianos S, Shapiro J, Wieck M, Buchmiller T, Brandt ML, Tracy T, Heiss K, Berman L
Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish.
1. Commun Biol - published January 5, 2024
2. Lawir DF, Soza-Ried C, Iwanami N, Siamishi I, Bylund GO, O Meara C, Sikora K, Kanzler B, Johansson E, Schorpp M, Cauchy P, Boehm T
The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses.
1. Nat Commun - published January 4, 2024
2. Ma H, Adams LJ, Raju S, Sariol A, Kafai NM, Janova H, Klimstra WB, Fremont DH, Diamond MS
The 100-protein NMR spectra dataset: A resource for biomolecular NMR data analysis.
1. Sci Data - published January 4, 2024
2. Klukowski P, Damberger FF, Allain FH, Iwai H, Kadavath H, Ramelot TA, Montelione GT, Riek R, Güntert P
Antigen self-anchoring onto bacteriophage T5 capsid-like particles for vaccine design.
1. NPJ Vaccines - published January 4, 2024
2. Vernhes E, Larbi Chérif L, Ducrot N, Vanbergue C, Ouldali M, Zig L, Sidibe N, Hoos S, Ramirez-Chamorro L, Renouard M, Rossier O, England P, Schoehn G, Boulanger P, Benihoud K
Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration.
1. Nat Microbiol - published January 4, 2024
2. Little AS, Younker IT, Schechter MS, Bernardino PN, Méheust R, Stemczynski J, Scorza K, Mullowney MW, Sharan D, Waligurski E, Smith R, Ramanswamy R, Leiter W, Moran D, McMillin M, Odenwald MA, Iavarone AT, Sidebottom AM, Sundararajan A, Pamer EG, Eren AM, Light SH
Immunoglobulin replacement products confer in vivo protection against SARS-CoV-2 XBB.1.5 Omicron variant despite poor neutralizing activity.
1. JCI Insight - published January 4, 2024
2. Zimmerman O, Altman Doss AM, Ying B, Liang CY, Mackin SR, Davis-Adams HG, Adams LJ, VanBlargan LA, Chen RE, Scheaffer SM, Desai P, Raju S, Mantia TL, O'Shaughnessy CC, Monroy JM, Wedner HJ, Rigell CJ, Kau AL, Dy TB, Ren Z, Turner JS, O'Halloran JA, Presti RM, Kendall PL, Fremont DH, Ellebedy AH, Diamond MS
PtuA and PtuB assemble into an inflammasome-like oligomer for anti-phage defense.
1. Nat Struct Mol Biol - published January 4, 2024
2. Li Y, Shen Z, Zhang M, Yang XY, Cleary SP, Xie J, Marathe IA, Kostelic M, Greenwald J, Rish AD, Wysocki VH, Chen C, Chen Q, Fu TM, Yu Y
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM.
1. Nat Struct Mol Biol - published January 4, 2024
2. Marcus K, Huang Y, Subramanian S, Gee CL, Gorday K, Ghaffari-Kashani S, Luo XR, Zheng L, O'Donnell M, Subramaniam S, Kuriyan J
Hepatitis C virus E1 recruits high-density lipoprotein to support infectivity and evade antibody recognition.
1. J Virol - published January 4, 2024
2. Casiano Matos J, Harichandran K, Tang J, Sviridov DO, Sidoti Migliore G, Suzuki M, Olano LR, Hobbs A, Kumar A, Paskel MU, Bonsignori M, Dearborn AD, Remaley AT, Marcotrigiano J
Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability.
1. Nat Commun - published January 4, 2024
2. Gorman J, Cheung CS, Duan Z, Ou L, Wang M, Chen X, Cheng C, Biju A, Sun Y, Wang P, Yang Y, Zhang B, Boyington JC, Bylund T, Charaf S, Chen SJ, Du H, Henry AR, Liu T, Sarfo EK, Schramm CA, Shen CH, Stephens T, Teng IT, Todd JP, Tsybovsky Y, Verardi R, Wang D, Wang S, Wang Z, Zheng CY, Zhou T, Douek DC, Mascola JR, Ho DD, Ho M, Kwong PD
Helical reconstruction of VP39 reveals principles for baculovirus nucleocapsid assembly.
1. Nat Commun - published January 4, 2024
2. Benning FMC, Jenni S, Garcia CY, Nguyen TH, Zhang X, Chao LH
Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques.
1. Cell - published January 4, 2024
2. Saunders KO, Counts J, Thakur B, Stalls V, Edwards R, Manne K, Lu X, Mansouri K, Chen Y, Parks R, Barr M, Sutherland L, Bal J, Havill N, Chen H, Machiele E, Jamieson N, Hora B, Kopp M, Janowska K, Anasti K, Jiang C, Van Itallie E, Venkatayogi S, Eaton A, Henderson R, Barbosa C, Alam SM, Santra S, Weissman D, Moody MA, Cain DW, Tam YK, Lewis M, Williams WB, Wiehe K, Montefiori DC, Acharya P, Haynes BF
Discovery of antitussive material basis and mechanisms in Citri Sarcodactylis Fructus by coupling UHPLC-Q/Orbitrap HRMS combined spectrum-effect relationship and metabolomics analyses.
1. J Chromatogr B Analyt Technol Biomed Life Sci - published January 4, 2024
2. Li X, Liu X, Gong Q, Duan T, Zhang M, Guo D, Wu W, Deng F
Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation.
1. bioRxiv - published January 4, 2024
2. Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
Structural basis of closed groove scrambling by a TMEM16 protein.
1. bioRxiv - published January 3, 2024
2. Feng Z, Alvarenga OE, Accardi A
Adaptation of SARS-CoV-2 to ACE2(H353K) mice reveals new spike residues that drive mouse infection.
1. J Virol - published January 3, 2024
2. Li K, Verma A, Li P, Ortiz ME, Hawkins GM, Schnicker NJ, Szachowicz PJ, Pezullo A, Wohlford-Lenane CL, Kicmal T, Meyerholz DK, Gallagher T, Perlman S, McCray PB Jr
Liquid Biopsy Proteomics in Ophthalmology.
1. J Proteome Res - published January 3, 2024
2. Wolf J, Franco JA, Yip R, Dabaja MZ, Velez G, Liu F, Bassuk AG, Mruthyunjaya P, Dufour A, Mahajan VB
Publisher Correction: Structural insights into cytokine cleavage by inflammatory caspase-4.
1. Nature - published January 3, 2024
2. Devant P, Dong Y, Mintseris J, Ma W, Gygi SP, Wu H, Kagan JC
Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques.
1. Nat Commun - published January 3, 2024
2. Sankhala RS, Lal KG, Jensen JL, Dussupt V, Mendez-Rivera L, Bai H, Wieczorek L, Mayer SV, Zemil M, Wagner DA, Townsley SM, Hajduczki A, Chang WC, Chen WH, Donofrio GC, Jian N, King HAD, Lorang CG, Martinez EJ, Rees PA, Peterson CE, Schmidt F, Hart TJ, Duso DK, Kummer LW, Casey SP, Williams JK, Kannan S, Slike BM, Smith L, Swafford I, Thomas PV, Tran U, Currier JR, Bolton DL, Davidson E, Doranz BJ, Hatziioannou T, Bieniasz PD, Paquin-Proulx D, Reiley WW, Rolland M, Sullivan NJ, Vasan S, Collins ND, Modjarrad K, Gromowski GD, Polonis VR, Michael NL, Krebs SJ, Joyce MG
A new antibiotic traps lipopolysaccharide in its intermembrane transporter.
1. Nature - published January 3, 2024
2. Pahil KS, Gilman MSA, Baidin V, Clairfeuille T, Mattei P, Bieniossek C, Dey F, Muri D, Baettig R, Lobritz M, Bradley K, Kruse AC, Kahne D
A novel antibiotic class targeting the lipopolysaccharide transporter.
1. Nature - published January 3, 2024
2. Zampaloni C, Mattei P, Bleicher K, Winther L, Thäte C, Bucher C, Adam JM, Alanine A, Amrein KE, Baidin V, Bieniossek C, Bissantz C, Boess F, Cantrill C, Clairfeuille T, Dey F, Di Giorgio P, du Castel P, Dylus D, Dzygiel P, Felici A, García-Alcalde F, Haldimann A, Leipner M, Leyn S, Louvel S, Misson P, Osterman A, Pahil K, Rigo S, Schäublin A, Scharf S, Schmitz P, Stoll T, Trauner A, Zoffmann S, Kahne D, Young JAT, Lobritz MA, Bradley KA
The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center.
1. Nat Chem Biol - published January 3, 2024
2. Coelho JPL, Yip MCJ, Oltion K, Taunton J, Shao S
Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis.
1. Proc Natl Acad Sci U S A - published January 3, 2024
2. Wang Y, Xu Z, Wu KL, Yu L, Wang C, Ding H, Gao Y, Sun H, Wu YH, Xia M, Chen Y, Xiao H
Amino acid and protein specificity of protein fatty acylation in C. elegans.
1. Proc Natl Acad Sci U S A - published January 3, 2024
2. Zhang B, Yu Y, Fox BW, Liu Y, Thirumalaikumar VP, Skirycz A, Lin H, Schroeder FC
Targeting transcription factors through an IMiD independent zinc finger domain.
1. bioRxiv - published January 3, 2024
2. Liu BH, Liu M, Radhakrishnan S, Jaladanki CK, Gao C, Tang JP, Kumari K, Go ML, Vu KAL, Seo HS, Song K, Tian X, Feng L, Tan JL, Bassal MA, Arthanari H, Qi J, Dhe-Paganon S, Fan H, Tenen DG, Chai L
Computational inference of eIF4F complex function and structure in human cancers.
1. Proc Natl Acad Sci U S A - published January 3, 2024
2. Wu S, Wagner G
Structure of Escherichia coli exonuclease VII.
1. Proc Natl Acad Sci U S A - published January 3, 2024
2. Liu C, Hauk G, Yan Q, Berger JM
Nucleic Acid Delivery Nanotechnologies for In Vivo Cell Programming.
1. ACS Appl Bio Mater - published January 3, 2024
2. Balcorta HV, Contreras Guerrero VG, Bisht D, Poon W
Characterization of a Diverse Set of Conditionally Reprogrammed Head and Neck Cancer Cell Cultures.
1. Laryngoscope - published January 3, 2024
2. Ow TJ, Mehta V, Li D, Thomas C, Shrivastava N, Kawachi N, Gersten AJ, Zhu J, Schiff BA, Smith RV, Rosenblatt G, Augustine S, Prystowsky MB, Yin S, Gavathiotis E, Guha C
LiaX is a surrogate marker for cell envelope stress and daptomycin non-susceptibility in Enterococcus faecium.
1. Antimicrob Agents Chemother - published January 3, 2024
2. Axell-House DB, Simar SR, Panesso D, Rincon S, Miller WR, Khan A, Pemberton OA, Valdez L, Nguyen AH, Hood KS, Rydell K, DeTranaltes AM, Jones MN, Atterstrom R, Reyes J, Sahasrabhojane PV, Suleyman G, Zervos M, Shelburne SA, Singh KV, Shamoo Y, Hanson BM, Tran TT, Arias CA
Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis.
1. Cell Discov - published January 3, 2024
2. Casanova AG, Roth GS, Hausmann S, Lu X, Bischoff LJM, Froeliger EM, Belmudes L, Bourova-Flin E, Flores NM, Benitez AM, Chasan T, Caporicci M, Vayr J, Blanchet S, Ielasi F, Rousseaux S, Hainaut P, Gozani O, Le Romancer M, Couté Y, Palencia A, Mazur PK, Reynoird N
Reply to "Considering Health Systems Worldwide: Point of View From a Middle-Income Country".
1. AJR Am J Roentgenol - published January 3, 2024
2. Tu LH, Melnick E, Venkatesh AK, Sheth KN, Navaratnam D, Yaesoubi R, Forman HP, Mahajan A
Dissecting the Interaction between Cryptochrome and Timeless Reveals Underpinnings of Light-Dependent Recognition.
1. Biochemistry - published January 3, 2024
2. Schneps CM, Dunleavy R, Crane BR
A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase.
1. Nucleic Acids Res - published January 3, 2024
2. Wang X, Jing X, Shi J, Liu Q, Shen S, Cheung PP, Wu J, Deng F, Gong P
Adaptive capacity of a DNA polymerase clamp-loader ATPase complex.
1. Mol Biol Evol - published January 3, 2024
2. Subramanian S, Zhang W, Nimkar S, Kamel M, O'Donnell M, Kuriyan J
A general platform for targeting MHC-II antigens via a single loop.
1. bioRxiv - published January 3, 2024
2. Du H, Liu J, Jude KM, Yang X, Li Y, Bell B, Yang H, Kassardjian A, Mobedi A, Parekh U, Sperberg RAP, Julien JP, Mellins ED, Garcia KC, Huang PS
Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus.
1. bioRxiv - published January 2, 2024
2. Ketaren NE, Mast FD, Fridy PC, Olivier JP, Sanyal T, Sali A, Chait BT, Rout MP, Aitchison JD
Rosetta Energy Analysis of AlphaFold2 models: Point Mutations and Conformational Ensembles.
1. bioRxiv - published January 2, 2024
2. Stein RA, Mchaourab HS
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
1. Proc Natl Acad Sci U S A - published January 2, 2024
2. Babbe H, Sundberg TB, Tichenor M, Seierstad M, Bacani G, Berstler J, Chai W, Chang L, Chung M, Coe K, Collins B, Finley M, Guletsky A, Lemke CT, Mak PA, Mathur A, Mercado-Marin EV, Metkar S, Raymond DD, Rives ML, Rizzolio M, Shaffer PL, Smith R, Smith J, Steele R, Steffens H, Suarez J, Tian G, Majewski N, Volak LP, Wei J, Desai PT, Ong LL, Koudriakova T, Goldberg SD, Hirst G, Kaushik VK, Ort T, Seth N, Graham DB, Plevy S, Venable JD, Xavier RJ, Towne JE
Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin.
1. Proc Natl Acad Sci U S A - published January 2, 2024
2. Finney J, Moseman AP, Kong S, Watanabe A, Song S, Walsh RM Jr, Kuraoka M, Kotaki R, Moseman EA, McCarthy KR, Liao D, Liang X, Nie X, Lavidor O, Abbott R, Harrison SC, Kelsoe G
B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.
1. Proc Natl Acad Sci U S A - published January 2, 2024
2. Wu CG, Balakrishnan VK, Merrill RA, Parihar PS, Konovolov K, Chen YC, Xu Z, Wei H, Sundaresan R, Cui Q, Wadzinski BE, Swingle MR, Musiyenko A, Chung WK, Honkanen RE, Suzuki A, Huang X, Strack S, Xing Y
Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT.
1. Chem Commun (Camb) - published January 2, 2024
2. Exapicheidou IA, Shams A, Ibrahim H, Tsarenko A, Backenköhler M, Hamed MM, Diamanti E, Volkamer A, Slotboom DJ, Hirsch AKH
Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP.
1. Nature - published January 2, 2024
2. Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF
Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer.
1. NPJ Breast Cancer - published January 2, 2024
2. Guerriero JL, Lin JR, Pastorello RG, Du Z, Chen YA, Townsend MG, Shimada K, Hughes ME, Ren S, Tayob N, Zheng K, Mei S, Patterson A, Taneja KL, Metzger O, Tolaney SM, Lin NU, Dillon DA, Schnitt SJ, Sorger PK, Mittendorf EA, Santagata S
Microbial co-occurrences on catheters from long-term catheterized patients.
1. Nat Commun - published January 2, 2024
2. Nye TM, Zou Z, Obernuefemann CLP, Pinkner JS, Lowry E, Kleinschmidt K, Bergeron K, Klim A, Dodson KW, Flores-Mireles AL, Walker JN, Wong DG, Desai A, Caparon MG, Hultgren SJ
Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties.
1. Bioorg Chem - published January 2, 2024
2. Kraft FB, Enns J, Honin I, Engelhardt J, Schöler A, Smith ST, Meiler J, Schäker-Hübner L, Weindl G, Hansen FK
CD73 contributes to the pathogenesis of fusion-negative rhabdomyosarcoma through the purinergic signaling pathway.
1. Proc Natl Acad Sci U S A - published January 2, 2024
2. Hernandez KC, Shah AM, Lopez VA, Tagliabracci VS, Chen K, Xu L, Bassel-Duby R, Olson EN, Liu N
Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity.
1. Nat Commun - published January 2, 2024
2. Zhang X, Pant SM, Ritch CC, Tang HY, Shao H, Dweep H, Gong YY, Brooks R, Brafford P, Wolpaw AJ, Lee Y, Weeraratna A, Sehgal A, Herlyn M, Kossenkov A, Speicher D, Sorger PK, Santagata S, Dang CV
Conservation of Hot Spots and Ligand Binding Sites in Protein Models by AlphaFold2.
1. J Chem Inf Model - published January 2, 2024
2. Bekar-Cesaretli AA, Khan O, Nguyen T, Kozakov D, Joseph-Mccarthy D, Vajda S
Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins.
1. J Med Chem - published January 2, 2024
2. Aziz F, Reddy K, Fernandez Vega V, Dey R, Hicks KA, Rao S, Jordan LO, Smith E, Shumate J, Scampavia L, Carpino N, Spicer TP, French JB
Disproportionate Rates of COVID-19 Among Black Canadian Communities: Lessons from a Cross-Sectional Study in the First Year of the Pandemic.
1. J Racial Ethn Health Disparities - published January 2, 2024
2. Allen UD, Barton M, Upton J, Bailey A, Campigotto A, Abdulnoor M, Julien JP, Gubbay J, Kissoon N, Litosh A, La Neve MR, Wong P, Allen A, Bailey R, Byrne W, Jagoowani R, Phillips C, Merreles-Pulcini M, Polack A, Prescod C, Siddiqi A, Summers A, Thompson K, Thompson S, James C, seroMARK Research Group
The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT(2A) receptor activation.
1. Eur J Pharmacol - published January 2, 2024
2. Arias HR, Rudin D, Hines DJ, Contreras A, Gulsevin A, Manetti D, Anouar Y, De Deurwaerdere P, Meiler J, Romanelli MN, Liechti ME, Chagraoui A
Trans-complementation by the RecB nuclease domain of RecBCD enzyme reveals new insight into RecA loading upon χ recognition.
1. Nucleic Acids Res - published January 2, 2024
2. Pavankumar TL, Wong CJ, Wong YK, Spies M, Kowalczykowski SC
Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation.
1. J Med Chem - published January 2, 2024
2. Kailass K, Casalena D, Jenane L, McEdwards G, Auld DS, Sadovski O, Kaye EG, Hudson E, Nettleton D, Currie MA, Beharry AA
HIV-1 capsids enter the FG phase of nuclear pores like a transport receptor.
1. Nature - published January 2, 2024
2. Fu L, Weiskopf EN, Akkermans O, Swanson NA, Cheng S, Schwartz TU, Görlich D
Identification of a druggable site on GRP78 at the GRP78-SARS-CoV-2 interface and virtual screening of compounds to disrupt that interface.
1. J Comput Aided Mol Des - published January 2, 2024
2. Lazou M, Hutton JR, Chakravarty A, Joseph-McCarthy D
TFE3-splicing factor fusions represent functional drivers and druggable targets in translocation renal cell carcinoma.
1. Cancer Res - published January 2, 2024
2. Damayanti NP, Cordova RA, Rupert C, Delle Fontane I, Shen L, Orsi S, Klunk AJ, Linehan WM, Staschke KA, Hollenhorst PC, Heppner DE, Pili R
Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice.
1. mBio - published January 2, 2024
2. Rosen AL, Lint MA, Voelker DH, Gilbert NM, Tomera CP, Santiago-Borges J, Wallace MA, Hannan TJ, Burnham C-AD, Hultgren SJ, Kau AL
Mechanistic Understanding of the Modes of Ca(2+) Ion Binding to the SARS-CoV-1 Fusion Peptide and Their Role in the Dynamics of Host Membrane Penetration.
1. ACS Infect Dis - published January 2, 2024
2. Carten JD, Khelashvili G, Bidon MK, Straus MR, Tang T, Jaimes JA, Whittaker GR, Weinstein H, Daniel S
Mutations in Tau Protein Promote Aggregation by Favoring Extended Conformations.
1. JACS Au - published January 2, 2024
2. Pounot K, Piersson C, Goring AK, Rosu F, Gabelica V, Weik M, Han S, Fichou Y
A Boron Scan of Ethyl Acetoacetate Leads to Versatile Building Blocks.
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Ensemble Structure of the N-terminal Domain (1-267) of FUS in a Biomolecular Condensate.
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The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A.
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The structure of the diheme cytochrome c(4) from Neisseria gonorrhoeae reveals multiple contributors to tuning reduction potentials.
1. J Inorg Biochem - published January 2, 2024
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Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding.
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Restraint Validation of Biomolecular Structures Determined by NMR in the Protein Data Bank.
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Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits.
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Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
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2. Adolf F, Du J, Goodall EA, Walsh RM Jr, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA
The NS1 protein of influenza B virus binds 5'-triphosphorylated dsRNA to suppress RIG-I activation and the host antiviral response.
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Unique Interactions of the Small Translocases of the Mitochondrial Inner Membrane (Tims) in Trypanosoma brucei.
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Novel LIPA-Targeted Therapy for Treating Ovarian Cancer.
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1. bioRxiv - published January 2, 2024
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Structural Studies of Henipavirus Glycoproteins.
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Structural insights into the complex of oncogenic KRas4B(G12V) and Rgl2, a RalA/B activator.
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C-SPAM: an open-source time-resolved specimen vitrification device with light-activated molecules.
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Characterization of the molecular mechanisms that govern anti-Müllerian hormone synthesis and activity.
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The CRISPR effector Cam1 mediates membrane depolarization for phage defence.
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Binding of GTP to BifA is required for the production of Pel-dependent biofilms in Pseudomonas aeruginosa.
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Author Correction: A new antibiotic traps lipopolysaccharide in its intermembrane transporter.
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Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-Demethylation.
1. Angew Chem Int Ed Engl - published January 1, 2024
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Low-Field, Low-Cost, Point-of-Care Magnetic Resonance Imaging.
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Macular dystrophy in Kabuki syndrome due to de novo KMT2D variants: refining the phenotype with multimodal imaging and follow-up over 10 years: insight into pathophysiology.
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Recent developments in membrane traffic and lipid dynamics.
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Approximating Projections of Conformational Boltzmann Distributions with AlphaFold2 Predictions: Opportunities and Limitations.
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Structural basis of prostaglandin efflux by MRP4.
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Concerted synergy between viral-specific IgG and CD8+ T cells is critical for clearance of an HCV-related rodent hepacivirus.
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Genetically modified ZIKA virus as a microRNA-sensitive oncolytic virus against central nervous system tumors.
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The Role of Attractive Non-Covalent Interactions in Peptide Macrocyclization.
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Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stage vaccine antigens inhibit sporozoite invasion of human hepatocytes in vitro.
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Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA.
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Histidine transport is essential for the growth of Staphylococcus aureus at low pH.
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The universal suppressor mutation restores membrane budding defects in the HSV-1 nuclear egress complex by stabilizing the oligomeric lattice.
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Speaking up for the invisible minority: First-generation students in higher education.
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Neuronal wiring receptors Dprs and DIPs are GPI anchored and this modification contributes to their cell surface organization.
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Massively parallel single-cell sequencing of diverse microbial populations.
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Antibodies targeting the fusion peptide on the HIV envelope provide protection to rhesus macaques against mucosal SHIV challenge.
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Phase II Study of Eribulin plus Pembrolizumab in Metastatic Soft Tissue Sarcomas: Clinical Outcomes and Biological Correlates.
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Characterization of tRNA splicing enzymes RNA ligase and tRNA 2'-phosphotransferase from the pathogenic fungi Mucorales.
1. RNA - published January 1, 2024
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Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by (31)P NMR.
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A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors.
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Identification of a Novel Subtype-Selective α(1B)-Adrenoceptor Antagonist.
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Iso-ADP-Ribose Fluorescence Polarization Probe for the Screening of RNF146 WWE Domain Inhibitors.
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Sotorasib is a pan-RASG12C inhibitor capable of driving clinical response in NRASG12C cancers.
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Neural Network Corrections to Intermolecular Interaction Terms of a Molecular Force Field Capture Nuclear Quantum Effects in Calculations of Liquid Thermodynamic Properties.
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Enhanced NF-κB activation via HIV-1 Tat-TRAF6 cross-talk.
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Health Care Simulation in Person and at a Distance: A Systematic Review.
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Dynamic social network analysis of a brief alcohol intervention trial in heavy-drinking college students shows spillover effects.
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SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination.
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Publisher Correction: Intermediate conformations of CD4-bound HIV-1 Env heterotrimers.
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Structural Insights into the DNA-Binding Mechanism of BCL11A: The Integral Role of ZnF6.
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Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody.
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Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa.
1. bioRxiv - published January 1, 2024
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Climbing the mountain of adversity and removing barriers along the path.
1. iScience - published January 1, 2024
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A compact regulatory RNA element in mouse Hsp70 mRNA.
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Conformational dynamics of adenylate kinase in crystals.
1. Struct Dyn - published January 1, 2024
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Crystallographic Studies of KRAS in Complex with Small Molecules and RAS-Binding Proteins.
1. Methods Mol Biol - published January 1, 2024
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