Member Publications

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123 Member Publications for August 2023

Structure of BTK kinase domain with the second-generation inhibitors acalabrutinib and tirabrutinib.
1. PLoS One - published August 31, 2023
2. Lin DY, Andreotti AH
Molecular Mechanism of PP2A/B55α Inhibition by IER5.
1. bioRxiv - published August 29, 2023
2. Cao R, Jones DT, Pan L, Wang S, Rawson S, Aster JC, Blacklow SC
Toward representative genomic research: the children's rare disease cohorts experience.
1. Ther Adv Rare Dis - published August 25, 2023
2. Frazier ZJ, Brown E, Rockowitz S, Lee T, Zhang B, Sveden A, Chamberlin NL, Dies KA, Poduri A, Sliz P, Chopra M
Antibodies Expand the Scope of Angiotensin Receptor Pharmacology.
1. bioRxiv - published August 24, 2023
2. Skiba MA, Sterling SM, Rawson S, Gilman MSA, Xu H, Nemeth GR, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Wingler LM, Kruse AC
De novo design of buttressed loops for sculpting protein functions.
1. bioRxiv - published August 23, 2023
2. Jiang H, Jude KM, Wu K, Fallas J, Ueda G, Brunette TJ, Hicks D, Pyles H, Yang A, Carter L, Lamb M, Li X, Levine PM, Stewart L, Garcia KC, Baker D
Structural insights into opposing actions of neurosteroids on GABA(A) receptors.
1. Nat Commun - published August 22, 2023
2. Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE
Structure and function of the human mitochondrial MRS2 channel.
1. bioRxiv - published August 15, 2023
2. He Z, Tu YC, Tsai CW, Mount J, Zhang J, Tsai MF, Yuan P
Interplay between Nrf2 and αB-crystallin in the lens and heart of zebrafish under proteostatic stress.
1. Front Mol Biosci - published August 14, 2023
2. Park J, MacGavin S, Niederbrach L, Mchaourab HS
Targeted shock-and-kill HIV-1 gene therapy approach combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery.
1. Gene Ther - published August 9, 2023
2. Klinnert S, Schenkel CD, Freitag PC, Günthard HF, Plückthun A, Metzner KJ
Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes.
1. Cell Rep - published August 9, 2023
2. Sankhala RS, Dussupt V, Donofrio G, Gromowski GD, De La Barrera RA, Larocca RA, Mendez-Rivera L, Lee A, Choe M, Zaky W, Mantus G, Jensen JL, Chen WH, Gohain N, Bai H, McCracken MK, Mason RD, Leggat D, Slike BM, Tran U, Jian N, Abbink P, Peterson R, Mendes EA, Freitas de Oliveira Franca R, Calvet GA, Bispo de Filippis AM, McDermott A, Roederer M, Hernandez M, Albertus A, Davidson E, Doranz BJ, Rolland M, Robb ML, Lynch RM, Barouch DH, Jarman RG, Thomas SJ, Modjarrad K, Michael NL, Krebs SJ, Joyce MG
Noncanonical HPV carcinogenesis drives radiosensitization of head and neck tumors.
1. Proc Natl Acad Sci U S A - published August 8, 2023
2. Schrank TP, Kothari A, Weir WH, Stepp WH, Rehmani H, Liu X, Wang X, Sewell A, Li X, Tasoulas J, Kim S, Yarbrough G, Xie Y, Flamand Y, Marur S, Hayward MC, Wu D, Burtness B, Anderson KS, Baldwin AS, Yarbrough WG, Issaeva N
A dual role for the chromatin reader ORCA/LRWD1 in targeting the origin recognition complex to chromatin.
1. EMBO J - published August 8, 2023
2. Sahu S, Ekundayo BE, Kumar A, Bleichert F
A conserved membrane curvature-generating protein is crucial for autophagosome formation in fission yeast.
1. Nat Commun - published August 8, 2023
2. Wang N, Shibata Y, Paulo JA, Gygi SP, Rapoport TA
Atypical bacterial Argonautes regulate antiphage defense.
1. Cell Res - published August 8, 2023
2. Chakravarti A, Patel DJ
Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery.
1. NPJ Vaccines - published August 8, 2023
2. Liu C, Wang L, Merriam JS, Shi W, Yang ES, Zhang Y, Chen M, Kong WP, Cheng C, Tsybovsky Y, Stephens T, Verardi R, Leung K, Stein C, Olia AS, Harris DR, Choe M, Zhang B, Graham BS, Kwong PD, Koup RA, Pegu A, Mascola JR
Dynamic players and intricate interactions: an integrated investigation of the Mla lipid transport system.
1. J Biol Chem - published August 8, 2023
2. Ng D, Moraes TF
Saddles as rotational locks within shape-assisted self-assembled nanosheets.
1. Nat Commun - published August 7, 2023
2. Woods JF, Gallego L, Maisch A, Renggli D, Cuocci C, Blacque O, Steinfeld G, Kaech A, Spingler B, Vargas Jentzsch A, Rickhaus M
Crystal structure of a cap-independent translation enhancer RNA.
1. Nucleic Acids Res - published August 7, 2023
2. Lewicka A, Roman C, Jones S, Disare M, Rice PA, Piccirilli JA
A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan.
1. Neuron - published August 7, 2023
2. Xu W, Rustenhoven J, Nelson CA, Dykstra T, Ferreiro A, Papadopoulos Z, Burnham CD, Dantas G, Fremont DH, Kipnis J
Characterization of a novel inhibitor for the New Delhi metallo-β-lactamase-4: implications for drug design and combating bacterial drug resistance.
1. J Biol Chem - published August 5, 2023
2. Thoden JB, Benin BM, Priebe A, Shin WS, Muthyala R, Sham YY, Holden HM
Cross-species analysis of transcriptome emphasizes a critical role of TNF-α in mediating MAP2K7/AKT2 signaling in zearalenone-induced apoptosis.
1. J Hazard Mater - published August 5, 2023
2. Zhang FL, Zhu KX, Wang JY, Zhang M, Yan JM, Liu QC, Zhang XY, Guo JC, Liu X, Sun QC, Ge W, Li L, Shen W
Structural basis of γ chain family receptor sharing at the membrane level.
1. Science - published August 4, 2023
2. Cai T, Lenoir Capello R, Pi X, Wu H, Chou JJ
Single-cell analysis of multiple invertible promoters reveals differential inversion rates as a strong determinant of bacterial population heterogeneity.
1. Sci Adv - published August 4, 2023
2. Lan F, Saba J, Qian Y, Ross T, Landick R, Venturelli OS
Metal Messengers: Communication in the Bacterial World through Transition-Metal-Sensing Two-Component Systems.
1. Biochemistry - published August 4, 2023
2. Paredes A, Iheacho C, Smith AT
A human antibody epitope map of the malaria vaccine antigen Pfs25.
1. NPJ Vaccines - published August 4, 2023
2. Shukla N, Tang WK, Coelho CH, Long CA, Healy SA, Sagara I, Miura K, Duffy PE, Tolia NH
Proteomic profiling across breast cancer cell lines and models.
1. Sci Data - published August 4, 2023
2. Kalocsay M, Berberich MJ, Everley RA, Nariya MK, Chung M, Gaudio B, Victor C, Bradshaw GA, Eisert RJ, Hafner M, Sorger PK, Mills CE, Subramanian K
Rethinking immunologic risk: a retrospective cohort study of severe SARS-CoV-2 infections in individuals with congenital immunodeficiencies.
1. J Allergy Clin Immunol Pract - published August 4, 2023
2. Nguyen AA, Habiballah SB, LaBere B, Day-Lewis M, Elkins M, Al-Musa A, Chu A, Jones J, Fried AJ, McDonald D, Hoytema van Konijnenburg DP, Rockowitz S, Sliz P, Oettgen HC, Schneider LC, MacGinnitie A, Bartnikas LM, Platt CD, Ohsumi TK, Chou J
On the Role of a Conserved Tryptophan in the Chromophore Pocket of Cyanobacteriochrome.
1. J Mol Biol - published August 4, 2023
2. Blain-Hartung M, Johannes von Sass G, Plaickner J, Katz S, Tu Hoang O, Andrea Mroginski M, Esser N, Budisa N, Forest KT, Hildebrandt P
New Insights into RNA processing by the eukaryotic tRNA Splicing Endonuclease.
1. J Biol Chem - published August 4, 2023
2. Hayne CK, Sekulovski S, Hurtig JE, Stanley RE, Trowitzsch S, van Hoof A
TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS.
1. J Mol Cell Biol - published August 3, 2023
2. Cicka D, Niu Q, Qui M, Qian K, Miller E, Fan D, Mo X, Ivanov AA, Sarafianos SG, Du Y, Fu H
Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism.
1. Elife - published August 3, 2023
2. Caveney NA, Tsutsumi N, Garcia KC
Chemoenzymatic Syntheses of Fluorine-18-Labeled Disaccharides from [(18)F] FDG Yield Potent Sensors of Living Bacteria In Vivo.
1. J Am Chem Soc - published August 3, 2023
2. Sorlin AM, López-Álvarez M, Rabbitt SJ, Alanizi AA, Shuere R, Bobba KN, Blecha J, Sakhamuri S, Evans MJ, Bayles KW, Flavell RR, Rosenberg OS, Sriram R, Desmet T, Nidetzky B, Engel J, Ohliger MA, Fraser JS, Wilson DM
Anamnestic humoral correlates of immunity across SARS-CoV-2 variants of concern.
1. mBio - published August 3, 2023
2. McNamara RP, Maron JS, Boucau J, Roy V, Webb NE, Bertera HL, Barczak AK, Positives Study Staff T, Franko N, Logue JK, Kemp M, Li JZ, Zhou L, Hsieh CL, McLellan JS, Siedner MJ, Seaman MS, Lemieux JE, Chu HY, Alter G
WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma.
1. Nat Cancer - published August 3, 2023
2. Rialdi A, Duffy M, Scopton AP, Fonseca F, Zhao JN, Schwarz M, Molina-Sanchez P, Mzoughi S, Arceci E, Abril-Fornaguera J, Meadows A, Ruiz de Galarreta M, Torre D, Reyes K, Lim YT, Rosemann F, Khan ZM, Mohammed K, Wang X, Yu X, Lakshmanan M, Rajarethinam R, Tan SY, Jin J, Villanueva A, Michailidis E, De Jong YP, Rice CM, Marazzi I, Hasson D, Llovet JM, Sobota RM, Lujambio A, Guccione E, Dar AC
A pentameric TRPV3 channel with a dilated pore.
1. Nature - published August 3, 2023
2. Lansky S, Betancourt JM, Zhang J, Jiang Y, Kim ED, Paknejad N, Nimigean CM, Yuan P, Scheuring S
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo.
1. PLoS Pathog - published August 3, 2023
2. Taha TY, Suryawanshi RK, Chen IP, Correy GJ, McCavitt-Malvido M, O'Leary PC, Jogalekar MP, Diolaiti ME, Kimmerly GR, Tsou CL, Gascon R, Montano M, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy.
1. Sci Transl Med - published August 3, 2023
2. Wellhausen N, O'Connell RP, Lesch S, Engel NW, Rennels AK, Gonzales D, Herbst F, Young RM, Garcia KC, Weiner D, June CH, Gill SI
Biology of the hepatitis B virus (HBV) core and capsid assembly modulators (CAMs) for chronic hepatitis B (CHB) cure.
1. Glob Health Med - published August 3, 2023
2. McFadden WM, Sarafianos SG
Metabolic modulation of mitochondrial mass during CD4(+) T cell activation.
1. Cell Chem Biol - published August 3, 2023
2. Kurmi K, Liang D, van de Ven R, Georgiev P, Gassaway BM, Han S, Notarangelo G, Harris IS, Yao CH, Park JS, Hu SH, Peng J, Drijvers JM, Boswell S, Sokolov A, Dougan SK, Sorger PK, Gygi SP, Sharpe AH, Haigis MC
Enhancing Anti-SARS-CoV-2 Neutralizing Immunity by Genetic Delivery of Enveloped Virus-like Particles Displaying SARS-CoV-2 Spikes.
1. Vaccines (Basel) - published August 3, 2023
2. Yang Y, Kong WP, Liu C, Ruckwardt TJ, Tsybovsky Y, Wang L, Wang S, Biner DW, Chen M, Liu T, Merriam J, Olia AS, Ou L, Qiu Q, Shi W, Stephens T, Yang ES, Zhang B, Zhang Y, Zhou Q, Rawi R, Koup RA, Mascola JR, Kwong PD
Slow Dissociation from the PARP1-HPF1 Complex Drives Inhibitor Potency.
1. Biochemistry - published August 2, 2023
2. Stojanovic P, Luger K, Rudolph J
NMR Shows Why a Small Chemical Change Almost Abolishes the Antimicrobial Activity of Glycocin F.
1. Biochemistry - published August 2, 2023
2. Harjes E, Edwards PJB, Bisset SW, Patchett ML, Jameson GB, Yang SH, Navo CD, Harris PWR, Brimble MA, Norris GE
Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases.
1. Phytother Res - published August 2, 2023
2. Liu X, Xu X, Zhang T, Xu L, Tao H, Liu Y, Zhang Y, Meng X
In Silico Discovery of Group II Intron RNA Splicing Inhibitors.
1. ACS Chem Biol - published August 2, 2023
2. Fedorova O, Arhin G, Pyle AM, Frank AT
Redox driven B(12)-ligand switch drives CarH photoresponse.
1. Nat Commun - published August 2, 2023
2. Poddar H, Rios-Santacruz R, Heyes DJ, Shanmugam M, Brookfield A, Johannissen LO, Levy CW, Jeffreys LN, Zhang S, Sakuma M, Colletier JP, Hay S, Schirò G, Weik M, Scrutton NS, Leys D
Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization.
1. Nat Struct Mol Biol - published August 2, 2023
2. Glögl M, Friedrich N, Cerutti G, Lemmin T, Kwon YD, Gorman J, Maliqi L, Mittl PRE, Hesselman MC, Schmidt D, Weber J, Foulkes C, Dingens AS, Bylund T, Olia AS, Verardi R, Reinberg T, Baumann NS, Rusert P, Dreier B, Shapiro L, Kwong PD, Plückthun A, Trkola A
Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen.
1. Nat Commun - published August 2, 2023
2. Wright KM, DiNapoli SR, Miller MS, Aitana Azurmendi P, Zhao X, Yu Z, Chakrabarti M, Shi W, Douglass J, Hwang MS, Hsiue EH, Mog BJ, Pearlman AH, Paul S, Konig MF, Pardoll DM, Bettegowda C, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S, Gabelli SB
SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b.
1. PLoS Pathog - published August 2, 2023
2. Aloise C, Schipper JG, van Vliet A, Oymans J, Donselaar T, Hurdiss DL, de Groot RJ, van Kuppeveld FJM
Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue.
1. Adv Biol (Weinh) - published August 2, 2023
2. Crabtree A, Neikirk K, Marshall AG, Vang L, Whiteside AJ, Williams Q, Altamura CT, Owens TC, Stephens D, Shao B, Koh A, Killion M, Lopez EG, Lam J, Rodriguez B, Mungai M, Stanley J, Dean ED, Koh HJ, Gaddy JA, Scudese E, Sweetwyne MT, Davis J, Zaganjor E, Murray SA, Katti P, Damo SM, Vue Z, Hinton A Jr
Mutations from patients with IPEX ported to mice reveal different patterns of FoxP3 and Treg dysfunction.
1. Cell Rep - published August 2, 2023
2. Leon J, Chowdhary K, Zhang W, Ramirez RN, André I, Hur S, Mathis D, Benoist C
Structural mechanism of mitochondrial membrane remodelling by human OPA1.
1. Nature - published August 2, 2023
2. von der Malsburg A, Sapp GM, Zuccaro KE, von Appen A, Moss FR 3rd, Kalia R, Bennett JA, Abriata LA, Dal Peraro M, van der Laan M, Frost A, Aydin H
Cell type-specific delivery by modular envelope design.
1. Nat Commun - published August 2, 2023
2. Strebinger D, Frangieh CJ, Friedrich MJ, Faure G, Macrae RK, Zhang F
The kinesin-5 tail and bipolar miniflament domains are the origin of its microtubule crosslinking and sliding activity.
1. Mol Biol Cell - published August 2, 2023
2. Nithianantham S, Iwanski MK, Gaska I, Pandey H, Bodrug T, Inagaki S, Major J, Brouhard GJ, Gheber L, Rosenfeld SS, Forth S, Hendricks AG, Al-Bassam J
Covariational reasoning and item context affect language in undergraduate mass balance written explanations.
1. Adv Physiol Educ - published August 2, 2023
2. Shiroda M, Doherty JH, Scott EE, Haudek KC
Next-generation proteomics for quantitative Jumbophage-bacteria interaction mapping.
1. Nat Commun - published August 2, 2023
2. Fossati A, Mozumdar D, Kokontis C, Mèndez-Moran M, Nieweglowska E, Pelin A, Li Y, Guo B, Krogan NJ, Agard DA, Bondy-Denomy J, Swaney DL
Three-Dimensional Mitochondria Reconstructions of Murine Cardiac Muscle Changes in Size Across Aging.
1. Am J Physiol Heart Circ Physiol - published August 2, 2023
2. Vue Z, Neikirk K, Vang L, Garza-Lopez E, Christensen TA, Shao J, Lam J, Beasley HK, Marshall AG, Crabtree A, Anudokem J Jr, Rodriguez B, Kirk B, Bacevac S, Barongan T, Shao B, Stephens DC, Kabugi K, Koh HJ, Koh A, Evans CS, Taylor B, Reddy AK, Miller-Fleming T, Actkins KV, Zaganjor E, Daneshgar N, Murray SA, Mobley BC, Damo S, Gaddy JA, Riggs B, Wanjalla C, Kirabo A, McReynolds M, Gomez JA, Phillips MA, Exil V, Dai DF, Hinton A Jr
Evaluating Scalable Supervised Learning for Synthesize-on-Demand Chemical Libraries.
1. J Chem Inf Model - published August 2, 2023
2. Alnammi M, Liu S, Ericksen SS, Ananiev GE, Voter AF, Guo S, Keck JL, Hoffmann FM, Wildman SA, Gitter A
Blocking the functional domain of TIP1 by antibodies sensitizes cancer to radiation therapy.
1. Biomed Pharmacother - published August 2, 2023
2. Singh AK, Dadey DY, Rau MJ, Fitzpatrick J, Shah HK, Saikia M, Townsend R, Thotala D, Hallahan DE, Kapoor V
Hexamethylene Amiloride Binds the SARS-CoV-2 Envelope Protein at the Protein-Lipid Interface.
1. Protein Sci - published August 2, 2023
2. Somberg NH, Medeiros-Silva J, Jo H, Wang J, DeGrado WF, Hong M
Assembly landscape for the bacterial large ribosomal subunit.
1. Nat Commun - published August 2, 2023
2. Sheng K, Li N, Rabuck-Gibbons JN, Dong X, Lyumkis D, Williamson JR
Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.
1. Cell - published August 2, 2023
2. Tsutsumi N, Masoumi Z, James SC, Tucker JA, Winkelmann H, Grey W, Picton LK, Moss L, Wilson SC, Caveney NA, Jude KM, Gati C, Piehler J, Hitchcock IS, Garcia KC
Trimethylated chitosan-coated flexible liposomes with resveratrol for topical drug delivery to reduce blue-light-induced retinal damage.
1. Int J Biol Macromol - published August 2, 2023
2. Gu H, Chen P, Liu X, Lian Y, Xi J, Li J, Song J, Li X
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
1. J Am Chem Soc - published August 2, 2023
2. Matsuda S, Bala S, Liao JY, Datta D, Mikami A, Woods L, Harp JM, Gilbert JA, Bisbe A, Manoharan RM, Kim M, Theile CS, Guenther DC, Jiang Y, Agarwal S, Maganti R, Schlegel MK, Zlatev I, Charisse K, Rajeev KG, Castoreno A, Maier M, Janas MM, Egli M, Chaput JC, Manoharan M
Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation.
1. Cell - published August 2, 2023
2. Lee SC, Adams DW, Ipsaro JJ, Cahn J, Lynn J, Kim HS, Berube B, Major V, Calarco JP, LeBlanc C, Bhattacharjee S, Ramu U, Grimanelli D, Jacob Y, Voigt P, Joshua-Tor L, Martienssen RA
Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer.
1. Eur J Nucl Med Mol Imaging - published August 2, 2023
2. Houvast RD, Badr N, March T, de Muynck LDAN, Sier VQ, Schomann T, Bhairosingh S, Baart VM, Peeters JAHM, van Westen GJP, Plückthun A, Burggraaf J, Kuppen PJK, Vahrmeijer AL, Sier CFM
A circadian-like gene network programs the timing and dosage of heterochronic miRNA transcription during C. elegans development.
1. Dev Cell - published August 2, 2023
2. Kinney B, Sahu S, Stec N, Hills-Muckey K, Adams DW, Wang J, Jaremko M, Joshua-Tor L, Keil W, Hammell CM
FAP-retargeted Ad5 enables in vivo gene delivery to stromal cells in the tumor microenvironment.
1. Mol Ther - published August 2, 2023
2. Hartmann KP, van Gogh M, Freitag PC, Kast F, Nagy-Davidescu G, Borsig L, Plückthun A
Functionalization and higher-order organization of liposomes with DNA nanostructures.
1. Nat Commun - published August 2, 2023
2. Zhang Z, Feng Z, Zhao X, Jean D, Yu Z, Chapman ER
Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3.
1. Protein Expr Purif - published August 2, 2023
2. Saitoh T, Kim HN, Narita R, Ohtsuka I, Mo W, Lee KY, Enomoto M, Gasmi-Seabrook GMC, Marshall CB, Ikura M
The virus-induced cyclic dinucleotide 2'3'-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila.
1. Immunity - published August 2, 2023
2. Cai H, Li L, Slavik KM, Huang J, Yin T, Ai X, Hédelin L, Haas G, Xiang Z, Yang Y, Li X, Chen Y, Wei Z, Deng H, Chen D, Jiao R, Martins N, Meignin C, Kranzusch PJ, Imler JL
High pressure freezing and cryo-sectioning can be used for protein structure determination by electron diffraction.
1. Ultramicroscopy - published August 2, 2023
2. Moriscot C, Schoehn G, Housset D
ABCG5/G8 Crystallization in a Lipidic Bicelle Environment for X-Ray Crystallography.
1. J Vis Exp - published August 2, 2023
2. Wazir S, Farhat D, Srinivasan M, Lee JY
Fetal brain tissue annotation and segmentation challenge results.
1. Med Image Anal - published August 1, 2023
2. Payette K, Li HB, de Dumast P, Licandro R, Ji H, Siddiquee MMR, Xu D, Myronenko A, Liu H, Pei Y, Wang L, Peng Y, Xie J, Zhang H, Dong G, Fu H, Wang G, Rieu Z, Kim D, Kim HG, Karimi D, Gholipour A, Torres HR, Oliveira B, Vilaça JL, Lin Y, Avisdris N, Ben-Zvi O, Bashat DB, Fidon L, Aertsen M, Vercauteren T, Sobotka D, Langs G, Alenyà M, Villanueva MI, Camara O, Fadida BS, Joskowicz L, Weibin L, Yi L, Xuesong L, Mazher M, Qayyum A, Puig D, Kebiri H, Zhang Z, Xu X, Wu D, Liao K, Wu Y, Chen J, Xu Y, Zhao L, Vasung L, Menze B, Cuadra MB, Jakab A
Structural basis of bidirectional allostery across the heme in a cytochrome P450 enzyme.
1. J Biol Chem - published August 1, 2023
2. Kumar A, Estrada DF
3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhibitor.
1. Acta Crystallogr D Struct Biol - published August 1, 2023
2. Martinez M, Batista FA, Maurel M, Bouillon A, Ortega Varga L, Wehenkel AM, Le Chevalier-Sontag L, Blondel A, Haouz A, Hernandez JF, Alzari PM, Barale JC
H3N2 influenza A virus gradually adapts to human-type receptor binding and entry specificity after the start of the 1968 pandemic.
1. Proc Natl Acad Sci U S A - published August 1, 2023
2. Liu M, Bakker AS, Narimatsu Y, van Kuppeveld FJM, Clausen H, de Haan CAM, de Vries E
Efficient tagging of endogenous proteins in human cell lines for structural studies by single-particle cryo-EM.
1. Proc Natl Acad Sci U S A - published August 1, 2023
2. Choi W, Wu H, Yserentant K, Huang B, Cheng Y
Nsp3-N interactions are critical for SARS-CoV-2 fitness and virulence.
1. Proc Natl Acad Sci U S A - published August 1, 2023
2. Li P, Xue B, Schnicker NJ, Wong LR, Meyerholz DK, Perlman S
A spatiotemporal Notch interaction map from plasma membrane to nucleus.
1. Sci Signal - published August 1, 2023
2. Martin AP, Bradshaw GA, Eisert RJ, Egan ED, Tveriakhina L, Rogers JM, Dates AN, Scanavachi G, Aster JC, Kirchhausen T, Kalocsay M, Blacklow SC
Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates.
1. PLoS Pathog - published August 1, 2023
2. Hermet P, Delache B, Herate C, Wolf E, Kivi G, Juronen E, Mumm K, Žusinaite E, Kainov D, Sankovski E, Virumäe K, Planken A, Merits A, Besaw JE, Yee AW, Morizumi T, Kim K, Kuo A, Berriche A, Dereuddre-Bosquet N, Sconosciuti Q, Naninck T, Relouzat F, Cavarelli M, Ustav M, Wilson D, Ernst OP, Männik A, LeGrand R, Ustav M Jr
Structural and functional characterization of the Sin Nombre virus L protein.
1. PLoS Pathog - published August 1, 2023
2. Meier K, Thorkelsson SR, Durieux Trouilleton Q, Vogel D, Yu D, Kosinski J, Cusack S, Malet H, Grünewald K, Quemin ERJ, Rosenthal M
Insight into the mechanism of H(+)-coupled nucleobase transport.
1. Proc Natl Acad Sci U S A - published August 1, 2023
2. Weng J, Zhou X, Wiriyasermkul P, Ren Z, Chen K, Gil-Iturbe E, Zhou M, Quick M
Progress in detection of and correction for low-energy contamination.
1. J Appl Crystallogr - published August 1, 2023
2. Domagala S, Nourd P, Diederichs K, Henn J
Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases.
1. iScience - published August 1, 2023
2. Olia AS, Cheng C, Zhou T, Biju A, Harris DR, Changela A, Duan H, Ivleva VB, Kong WP, Ou L, Rawi R, Tsybovsky Y, Van Wazer DJ, Corrigan AR, Gonelli CA, Lee M, McKee K, Narpala S, O'Dell S, Parchment DK, Stancofski ED, Stephens T, Tan I, Teng IT, Wang S, Wei Q, Yang Y, Yang Z, Zhang B, VRC Production Program, Novak J, Renfrow MB, Doria-Rose NA, Koup RA, McDermott AB, Gall JG, Lei QP, Mascola JR, Kwong PD
High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase.
1. Nat Commun - published August 1, 2023
2. Yang L, Wagner T, Mechaly A, Boyko A, Bruch EM, Megrian D, Gubellini F, Alzari PM, Bellinzoni M
Ultrafast dense DNA functionalization of quantum dots and rods for scalable 2D array fabrication with nanoscale precision.
1. Sci Adv - published August 1, 2023
2. Chen C, Luo X, Kaplan AEK, Bawendi MG, Macfarlane RJ, Bathe M
Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
1. Nat Commun - published August 1, 2023
2. Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits.
1. Protein Sci - published August 1, 2023
2. Mays SG, Hercules D, Ortlund EA, Okafor CD
CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity.
1. J Mol Biol - published August 1, 2023
2. Adolph MB, Garje AS, Balakrishnan S, Morati F, Modesti M, Chazin WJ, Cortez D
Radiation damage to biological macromolecules∗.
1. Curr Opin Struct Biol - published August 1, 2023
2. Garman EF, Weik M
Multimeric structure of a subfamily III haloalkane dehalogenase-like enzyme solved by combination of cryo-EM and X-ray crystallography.
1. Protein Sci - published August 1, 2023
2. Chmelova K, Gao T, Polak M, Schenkmayerova A, Croll TI, Shaikh TR, Skarupova J, Chaloupkova R, Diederichs K, Read RJ, Damborsky J, Novacek J, Marek M
Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly.
1. Cell Rep - published August 1, 2023
2. Xie Y, Gao S, Zhang K, Bhat P, Clarke BP, Batten K, Mei M, Gazzara M, Shay JW, Lynch KW, Angelos AE, Hill PS, Ivey AL, Fontoura B, Ren Y
Small molecule inhibitors of the fosfomycin resistance enzyme FosM from Mycobacterium abscessus.
1. Biochim Biophys Acta Gen Subj - published August 1, 2023
2. Chiasson S, Smith T, Bello L, Chandrika NT, Green KD, Garneau-Tsodikova S, Thompson MK
The road not taken en route to T cell exhaustion.
1. Nat Immunol - published August 1, 2023
2. Dash B, Hogan PG
Reevaluation of bromodomain ligands targeting BAZ2A.
1. Protein Sci - published August 1, 2023
2. Cazzanelli G, Vedove AD, Parolin E, D'Agostino VG, Unzue A, Nevado C, Caflisch A, Lolli G
Capturing receptor states with glue.
1. Nat Chem Biol - published August 1, 2023
2. Bernhard SM, Che T
Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme uptake.
1. bioRxiv - published August 1, 2023
2. Knejski PP, Erramilli SK, Kossiakoff AA
Platelet factors attenuate inflammation and rescue cognition in ageing.
1. Nature - published August 1, 2023
2. Schroer AB, Ventura PB, Sucharov J, Misra R, Chui MKK, Bieri G, Horowitz AM, Smith LK, Encabo K, Tenggara I, Couthouis J, Gross JD, Chan JM, Luke A, Villeda SA
Fission yeast poly(A) polymerase active site mutation Y86D alleviates the rad24∆ asp1-H397A synthetic growth defect and upregulates mRNAs targeted by MTREC and Mmi1.
1. RNA - published August 1, 2023
2. Garg A, Schwer B, Shuman S
Pharmacological perturbation of the phase-separating protein SMNDC1.
1. Nat Commun - published August 1, 2023
2. Enders L, Siklos M, Borggräfe J, Gaussmann S, Koren A, Malik M, Tomek T, Schuster M, Reiniš J, Hahn E, Rukavina A, Reicher A, Casteels T, Bock C, Winter GE, Hannich JT, Sattler M, Kubicek S
Models for human telomere C-strand fill-in by CST-Polα-primase.
1. Trends Biochem Sci - published August 1, 2023
2. He Q, Lim CJ
Two sequence- and two structure-based ML models have learned different aspects of protein biochemistry.
1. Sci Rep - published August 1, 2023
2. Kulikova AV, Diaz DJ, Chen T, Cole TJ, Ellington AD, Wilke CO
The 2023 Structural Biology Summit at UCLA.
1. Structure - published August 1, 2023
2. Nannenga BL, Gonen T
A RAD51-ADP double filament structure unveils the mechanism of filament dynamics in homologous recombination.
1. Nat Commun - published August 1, 2023
2. Luo SC, Yeh MC, Lien YH, Yeh HY, Siao HL, Tu IP, Chi P, Ho MC
Emerging vaccine strategies against the incessant pneumococcal disease.
1. NPJ Vaccines - published August 1, 2023
2. Duke JA, Avci FY
The dual lipid desaturase/hydroxylase DEGS2 controls phytoceramide levels necessary to counter intestinal inflammation.
1. Dis Model Mech - published August 1, 2023
2. Song R, Fond A, Li X, Tang M, Zhan X, Gordillo R, Moresco EMY, Beutler B, Turer EE
SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans.
1. PLoS Biol - published August 1, 2023
2. DeGroot MS, Williams B, Chang TY, Maas Gamboa ML, Larus IM, Hong G, Fromme JC, Liu J
Harnessing Aromatic-Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification.
1. Angew Chem Int Ed Engl - published August 1, 2023
2. Yu Z, Kreitler DF, Chiu YTT, Xu R, Bruchs AT, Bingman CA, Gellman SH
A Hybrid Structure-Based Machine Learning Approach for Predicting Kinase Inhibition by Small Molecules.
1. J Chem Inf Model - published August 1, 2023
2. Liu C, Kutchukian P, Nguyen ND, AlQuraishi M, Sorger PK
Combining native mass spectrometry and lipidomics to uncover specific membrane protein-lipid interactions from natural lipid sources.
1. Chem Sci - published August 1, 2023
2. Zhu Y, Odenkirk MT, Qiao P, Zhang T, Schrecke S, Zhou M, Marty MT, Baker ES, Laganowsky A
Temporal modelling of the biofilm lifecycle (TMBL) establishes kinetic analysis of plate-based bacterial biofilm dynamics.
1. J Microbiol Methods - published August 1, 2023
2. Enriquez KT, Plummer WD, Neufer PD, Chazin WJ, Dupont WD, Skaar EP
Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.
1. J Allergy Clin Immunol - published August 1, 2023
2. O'Meara TR, Nanishi E, McGrath ME, Barman S, Dong D, Dillen C, Menon M, Seo HS, Dhe-Paganon S, Ernst RK, Levy O, Frieman MB, Dowling DJ
A potent and durable malaria transmission-blocking vaccine designed from a single-component 60-copy Pfs230D1 nanoparticle.
1. NPJ Vaccines - published August 1, 2023
2. Salinas ND, Ma R, Dickey TH, McAleese H, Ouahes T, Long CA, Miura K, Lambert LE, Tolia NH
Chromophore carbonyl twisting in fluorescent biosensors encodes direct readout of protein conformations with multicolor switching.
1. Commun Chem - published August 1, 2023
2. Allert MJ, Kumar S, Wang Y, Beese LS, Hellinga HW
Dynamic genetic adaptation of Bacteroides thetaiotaomicron during murine gut colonization.
1. Cell Rep - published August 1, 2023
2. Kennedy MS, Zhang M, DeLeon O, Bissell J, Trigodet F, Lolans K, Temelkova S, Carroll KT, Fiebig A, Deutschbauer A, Sidebottom AM, Lake J, Henry C, Rice PA, Bergelson J, Chang EB
The intricacies of Ebola NP(0)VP35 formation of inclusion body-like structures and their disruption reducing viral infection.
1. J Mol Biol - published August 1, 2023
2. Wu C, Wagner N, Moyle AB, Feng A, Sharma N, Stubbs SH, Donahue C, Davey RA, Gross ML, Leung DW, Amarasinghe GK
Strategies for Overcoming the Single-Molecule Concentration Barrier.
1. ACS Meas Sci Au - published August 1, 2023
2. White DS, Smith MA, Chanda B, Goldsmith RH
Real-time bio-layer interferometry ubiquitination assays as alternatives to western blotting.
1. Anal Biochem - published August 1, 2023
2. De Silva ARI, Shrestha S, Page RC
Structure-Based Design of Inhibitors of the m(6)A-RNA Writer Enzyme METTL3.
1. ACS Bio Med Chem Au - published August 1, 2023
2. Bedi RK, Huang D, Li Y, Caflisch A
Paired evaluation of machine-learning models characterizes effects of confounders and outliers.
1. Patterns (N Y) - published August 1, 2023
2. Nariya MK, Mills CE, Sorger PK, Sokolov A
Precision Grinding Technology of Silicon Carbide (SiC) Ceramics by Longitudinal Torsional Ultrasonic Vibrations.
1. Materials (Basel) - published August 1, 2023
2. Ye Z, Wen X, Wan W, Liu F, Bai W, Xu C, Chen H, Gong P, Han G
Identification of the Solid Stem Suppressor Gene Su-TdDof in Synthetic Hexaploid Wheat Syn-SAU-117.
1. Int J Mol Sci - published August 1, 2023
2. Li H, Liu X, Zhang J, Chen L, Zhang M, Miao Y, Ma P, Hao M, Jiang B, Ning S, Huang L, Yuan Z, Chen X, Chen X, Liu D, Wan H, Zhang L
Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.
1. Redox Biol - published August 1, 2023
2. Hong L, Braden DC, Zhao Y, Skoko JJ, Chang F, Woodcock SR, Uvalle C, Casey A, Wood K, Salvatore SR, Asan A, Harkness T, Fagunloye A, Razzaghi M, Straub A, Spies M, Brown DD, Lee AV, Schopfer F, Freeman BA, Neumann CA