Member Publications

Jump to specific year:

157 Member Publications for March 2023

Batch Production of High-Quality Graphene Grids for Cryo-EM: Cryo-EM Structure of Methylococcus capsulatus Soluble Methane Monooxygenase Hydroxylase.
1. ACS Nano - published March 28, 2023
2. Ahn E, Kim B, Park S, Erwin AL, Sung SH, Hovden R, Mosalaganti S, Cho US
Finding priority bacterial ribosomes for future structural and antimicrobial research based upon global RNA and protein sequence analysis.
1. PeerJ - published March 28, 2023
2. Cooper HB, Krause KL, Gardner PP
A simple flash and freeze system for cryogenic time-resolved electron microscopy.
1. Front Mol Biosci - published March 24, 2023
2. Bhattacharjee B, Rahman MM, Hibbs RE, Stowell MHB
Spatial-temporal evolution and convergence analysis of agricultural green total factor productivity-evidence from the Yangtze River Delta Region of China.
1. PLoS One - published March 20, 2023
2. Bao H, Liu X, Xu X, Shan L, Ma Y, Qu X, He X
Promising Nanomedicines of Shikonin for Cancer Therapy.
1. Int J Nanomedicine - published March 17, 2023
2. Yan C, Li Q, Sun Q, Yang L, Liu X, Zhao Y, Shi M, Li X, Luo K
Avidity engineering of human heavy-chain-only antibodies mitigates neutralization resistance of SARS-CoV-2 variants.
1. Front Immunol - published March 10, 2023
2. Du W, Janssens R, Mykytyn AZ, Li W, Drabek D, van Haperen R, Chatziandreou M, Rissmann M, van der Lee J, van Dortmondt M, Martin IS, van Kuppeveld FJM, Hurdiss DL, Haagmans BL, Grosveld F, Bosch BJ
Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly.
1. Elife - published March 10, 2023
2. Takahashi H, Yamada T, Denton JS, Strange K, Karakas E
cGAMP-activated cGAS-STING signaling: its bacterial origins and evolutionary adaptation by metazoans.
1. Nat Struct Mol Biol - published March 9, 2023
2. Patel DJ, Yu Y, Xie W
SARS-CoV-2 Exposure in Norway Rats (Rattus norvegicus) from New York City.
1. mBio - published March 9, 2023
2. Wang Y, Lenoch J, Kohler D, DeLiberto TJ, Tang CY, Li T, Tao YJ, Guan M, Compton S, Zeiss C, Hang J, Wan XF
Inhibition of nonsense-mediated decay induces nociceptive sensitization through activation of the integrated stress response.
1. J Neurosci - published March 9, 2023
2. de la Peña JB, Chase R, Kunder N, Smith PR, Lou TF, Stanowick A, Suresh P, Shukla T, Butcher SE, Price T, Campbell ZT
Clinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness.
1. PLoS One - published March 9, 2023
2. Tu LH, Malhotra A, Venkatesh AK, Taylor RA, Sheth KN, Yaesoubi R, Forman HP, Sureshanand S, Navaratnam D
Mre11-Rad50: the DNA end game.
1. Biochem Soc Trans - published March 9, 2023
2. Hopfner KP
mSphere of Influence: the Young Investigators in Parasitology Meeting-Investing in the Future of Our Scientific Community by Lifting Up and Connecting Junior Faculty.
1. mSphere - published March 9, 2023
2. Mugnier MR, Ho CM
The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11.
1. Cell Rep - published March 9, 2023
2. Boehm D, Lam V, Schnolzer M, Ott M
A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay.
1. Sci Rep - published March 8, 2023
2. Alexander-Howden B, Zhang L, van der Sloot AM, Tollis S, St-Cyr DJ, Sicheri F, Bird AP, Tyers M, Lyst MJ
The Self-Association of the KRAS4b Protein is Altered by Lipid-Bilayer Composition and Electrostatics.
1. Angew Chem Int Ed Engl - published March 8, 2023
2. Lee KY, Ikura M, Marshall CB
Polysaccharide-Based Stimulus-Responsive Nanomedicines for Combination Cancer Immunotherapy.
1. Small - published March 8, 2023
2. Li Q, Liu X, Yan C, Zhao B, Zhao Y, Yang L, Shi M, Yu H, Li X, Luo K
Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms.
1. Structure - published March 8, 2023
2. Papasergi-Scott MM, Kwarcinski FE, Yu M, Panova O, Ovrutsky AM, Skiniotis G, Tall GG
The effect of low-carbon transportation pilot policy on carbon performance: evidence from China.
1. Environ Sci Pollut Res Int - published March 7, 2023
2. Zhang X, He P, Liu X, Lu T
Prolactin levels and breast cancer risk by tumor expression of prolactin-related markers.
1. Breast Cancer Res - published March 7, 2023
2. Hathaway CA, Rice MS, Collins LC, Chen D, Frank DA, Walker S, Clevenger CV, Tamimi RM, Tworoger SS, Hankinson SE
Chemistry, structure and function of approved oligonucleotide therapeutics.
1. Nucleic Acids Res - published March 7, 2023
2. Egli M, Manoharan M
Monomer and dimer structures of cytochrome bo(3) ubiquinol oxidase from Escherichia coli.
1. Protein Sci - published March 7, 2023
2. Guo Y, Karimullina E, Emde T, Otwinowski Z, Borek D, Savchenko A
Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination.
1. RNA - published March 7, 2023
2. Sanchez AM, Garg A, Schwer B, Shuman S
Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP) endonuclease activity.
1. Nucleic Acids Res - published March 7, 2023
2. Dorival J, Eichman BF
Association of blood manganese concentrations with 24-h based brachial and central blood pressure, and pulse-wave velocity.
1. Environ Res - published March 7, 2023
2. M CR, R O, M SP, A G, F RA, Jr B, García-Esquinas E
Pyrrolizidine alkaloids in borage (Borago officinalis): Comprehensive profiling and development of a validated LC-MS/MS method for quantification.
1. Talanta - published March 7, 2023
2. Sattler M, Müller V, Bunzel D, Kulling SE, Soukup ST
Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state.
1. J Gen Physiol - published March 6, 2023
2. Cowgill J, Chanda B
Enterovirus D-68 Infection of Primary Rat Cortical Neurons: Entry, Replication, and Functional Consequences.
1. mBio - published March 6, 2023
2. Poelaert KCK, van Kleef RGDM, Liu M, van Vliet A, Lyoo H, Gerber LS, Narimatsu Y, Büll C, Clausen H, de Vries E, Westerink RHS, van Kuppeveld FJM
Structure-Based Design of Bisubstrate Tetracycline Destructase Inhibitors That Block Flavin Redox Cycling.
1. J Med Chem - published March 6, 2023
2. Williford EE, DeAngelo CM, Blake KS, Kumar H, Lam KK, Jones KV, Tolia NH, Dantas G, Wencewicz TA
Designer molecules of the synaptic organizer MDGA1 reveal 3D conformational control of biological function.
1. J Biol Chem - published March 6, 2023
2. Lee H, Chofflet N, Liu J, Fan S, Lu Z, Rojas M, Penndorf P, Bailey A, Russell W, Machius M, Ren G, Takahashi H, Rudenko G
CryoEM single particle reconstruction with a complex-valued particle stack.
1. J Struct Biol - published March 6, 2023
2. Bromberg R, Guo Y, Borek D, Otwinowski Z
Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines.
1. Cell Rep - published March 6, 2023
2. Dickey TH, Ma R, Orr-Gonzalez S, Ouahes T, Patel P, McAleese H, Butler B, Eudy E, Eaton B, Murphy M, Kwan JL, Salinas ND, Holbrook MR, Lambert LE, Tolia NH
Robust total X-ray scattering workflow to study correlated motion of proteins in crystals.
1. Nat Commun - published March 3, 2023
2. Meisburger SP, Case DA, Ando N
Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice.
1. NPJ Vaccines - published March 3, 2023
2. Nanishi E, Borriello F, Seo HS, O'Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O
Systematic Transmission Electron Microscopy-Based Identification and 3D Reconstruction of Cellular Degradation Machinery.
1. Adv Biol (Weinh) - published March 3, 2023
2. Neikirk K, Vue Z, Katti P, Rodriguez BI, Omer S, Shao J, Christensen T, Garza Lopez E, Marshall A, Palavicino-Maggio CB, Ponce J, Alghanem AF, Vang L, Barongan T, Beasley HK, Rodman T, Stephens D, Mungai M, Correia M, Exil V, Damo S, Murray SA, Crabtree A, Glancy B, Pereira RO, Abel ED, Hinton AO Jr
Design, synthesis, and biological testing of biphenylmethyloxazole inhibitors targeting HIV-1 reverse transcriptase.
1. Bioorg Med Chem Lett - published March 3, 2023
2. Carter ZJ, Hollander K, Spasov KA, Anderson KS, Jorgensen WL
B cell receptor signaling in germinal centers prolongs survival and primes B cells for selection.
1. Immunity - published March 3, 2023
2. Chen ST, Oliveira TY, Gazumyan A, Cipolla M, Nussenzweig MC
Urinary tract infections trigger synucleinopathy via the innate immune response.
1. Acta Neuropathol - published March 3, 2023
2. Peelaerts W, Mercado G, George S, Villumsen M, Kasen A, Aguileta M, Linstow C, Sutter AB, Kuhn E, Stetzik L, Sheridan R, Bergkvist L, Meyerdirk L, Lindqvist A, Gavis MLE, Van den Haute C, Hultgren SJ, Baekelandt V, Pospisilik JA, Brudek T, Aznar S, Steiner JA, Henderson MX, Brundin L, Ivanova MI, Hannan TJ, Brundin P
Mapping the conformational landscape of the stimulatory heterotrimeric G protein.
1. Nat Struct Mol Biol - published March 3, 2023
2. Huang SK, Picard LP, Rahmatullah RSM, Pandey A, Van Eps N, Sunahara RK, Ernst OP, Sljoka A, Prosser RS
A Vaccinia-based system for directed evolution of GPCRs in mammalian cells.
1. Nat Commun - published March 3, 2023
2. Klenk C, Scrivens M, Niederer A, Shi S, Mueller L, Gersz E, Zauderer M, Smith ES, Strohner R, Plückthun A
G-quadruplexes in bacteria: insights into the regulatory roles and interacting proteins of non-canonical nucleic acid structures.
1. Crit Rev Biochem Mol Biol - published March 3, 2023
2. Cueny RR, McMillan SD, Keck JL
Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6.
1. Nat Commun - published March 3, 2023
2. Colucci E, Anshari ZR, Patiño-Ruiz MF, Nemchinova M, Whittaker J, Slotboom DJ, Guskov A
Structural insights into the mechanism of leptin receptor activation.
1. Nat Commun - published March 3, 2023
2. Saxton RA, Caveney NA, Moya-Garzon MD, Householder KD, Rodriguez GE, Burdsall KA, Long JZ, Garcia KC
Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins (RAMPs).
1. J Biol Chem - published March 3, 2023
2. Kotliar IB, Ceraudo E, Kemelmakher-Liben K, Oren DA, Lorenzen E, Dodig-Crnković T, Horioka-Duplix M, Huber T, Schwenk JM, Sakmar TP
Molecular evidence of widespread benzimidazole drug resistance in Ancylostoma caninum from domestic dogs throughout the USA and discovery of a novel β-tubulin benzimidazole resistance mutation.
1. PLoS Pathog - published March 2, 2023
2. Venkatesan A, Jimenez Castro PD, Morosetti A, Horvath H, Chen R, Redman E, Dunn K, Collins JB, Fraser JS, Anderson EC, Kaplan RM, Gilleard JS
GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production.
1. Sci Rep - published March 2, 2023
2. Sandouk A, Xu Z, Baruah S, Tremblay M, Hopkins JB, Chakravarthy S, Gakhar L, Schnicker NJ, Houtman JCD
Cryo-EM structure of coagulation factor V short.
1. Blood - published March 2, 2023
2. Mohammed BM, Pelc LA, Rau MJ, Di Cera E
Machine learning for the identification of respiratory viral attachment machinery from sequences data.
1. PLoS One - published March 2, 2023
2. Walker KC, Shwarts M, Demidikin S, Chakravarty A, Joseph-McCarthy D
Near-physiological in vitro assembly of 50S ribosomes involves parallel pathways.
1. Nucleic Acids Res - published March 2, 2023
2. Dong X, Doerfel LK, Sheng K, Rabuck-Gibbons JN, Popova AM, Lyumkis D, Williamson JR
Megahertz sampling of prestin (SLC26a5) voltage-sensor charge movements in outer hair cell membranes reveals ultrasonic activity that may support electromotility and cochlear amplification.
1. J Neurosci - published March 2, 2023
2. Santos-Sacchi J, Bai JP, Navaratnam D
Freestanding lipid bilayer tensiometer for the study of mechanosensitive ion channels.
1. Proc Natl Acad Sci U S A - published March 2, 2023
2. Pérez-Mitta G, MacKinnon R
EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.
1. Proc Natl Acad Sci U S A - published March 2, 2023
2. Yang H, Yuan P, Wu Y, Shi M, Caro CD, Tengeiji A, Yamanoi S, Inoue M, DeGrado WF, Condello C
Total chemical synthesis of sumoylated histone H4 reveals negative biochemical crosstalk with histone ubiquitylation.
1. Chem Commun (Camb) - published March 2, 2023
2. Singh SK, Reyna A, Xie X, Mao H, Ji M, Zheng N, Hsu PL, Chatterjee C
Automated assembly of molecular mechanisms at scale from text mining and curated databases.
1. Mol Syst Biol - published March 2, 2023
2. Bachman JA, Gyori BM, Sorger PK
Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor.
1. Proc Natl Acad Sci U S A - published March 2, 2023
2. Yang K, Wang C, Kreutzberger AJB, White KI, Pfuetzner RA, Esquivies L, Kirchhausen T, Brunger AT
Structures of ferroportin in complex with its specific inhibitor vamifeport.
1. Elife - published March 2, 2023
2. Lehmann EF, Liziczai M, Drożdżyk K, Altermatt P, Langini C, Manolova V, Sundstrom H, Dürrenberger F, Dutzler R, Manatschal C
Structural Study of the Cobetia marina Bacteriophage 1 (Carin-1) by Cryo-EM.
1. J Virol - published March 2, 2023
2. d'Acapito A, Roret T, Zarkadas E, Mocaër PY, Lelchat F, Baudoux AC, Schoehn G, Neumann E
Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses.
1. Elife - published March 2, 2023
2. Silva RP, Huang Y, Nguyen AW, Hsieh CL, Olaluwoye OS, Kaoud TS, Wilen RE, Qerqez AN, Park JG, Khalil AM, Azouz LR, Le KC, Bohanon AL, DiVenere AM, Liu Y, Lee AG, Amengor DA, Shoemaker SR, Costello SM, Padlan EA, Marqusee S, Martinez-Sobrido L, Dalby KN, D'Arcy S, McLellan JS, Maynard JA
The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores.
1. Proc Natl Acad Sci U S A - published March 2, 2023
2. Shen Q, Kumari S, Xu C, Jang S, Shi J, Burdick RC, Levintov L, Xiong Q, Wu C, Devarkar SC, Tian T, Tripler TN, Hu Y, Yuan S, Temple J, Feng Q, Lusk CP, Aiken C, Engelman AN, Perilla JR, Pathak VK, Lin C, Xiong Y
LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p.
1. Mol Biotechnol - published March 2, 2023
2. Xu J, Hu M, Gao Y, Wang Y, Yuan X, Yang Y, Song W, Yin W, Gong P, Wei L, Zhang J
Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
1. Proc Natl Acad Sci U S A - published March 2, 2023
2. Krimmer SG, Bertoletti N, Suzuki Y, Katic L, Mohanty J, Shu S, Lee S, Lax I, Mi W, Schlessinger J
Author Correction: Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.
1. Nat Commun - published March 2, 2023
2. Maben Z, Arya R, Georgiadis D, Stratikos E, Stern LJ
Structural Variation Cooperates with Permissive Chromatin to Control Enhancer Hijacking-Mediated Oncogenic Transcription.
1. Blood - published March 2, 2023
2. Botten G, Zhang Y, Dudnyk K, Kim YJ, Liu X, Sanders JT, Imanci A, Droin NM, Cao H, Kaphle P, Dickerson KE, Kumar KR, Chen M, Chen W, Solary E, Ly P, Zhou J, Xu J
A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
1. Blood - published March 2, 2023
2. Andersen JF, Lei H, Strayer EC, Kanai T, Pham V, Pan XZ, Alvarenga PH, Gerber GF, Asojo OA, Francischetti IM, Brodsky RA, Valenzuela JG, Ribeiro J
β-Boron Effect Enables Regioselective and Stereospecific Electrophilic Addition to Alkenes.
1. J Am Chem Soc - published March 2, 2023
2. Li Y, Fan WX, Luo S, Trofimova A, Liu Y, Xue JH, Yang L, Li Q, Wang H, Yudin AK
Chemical tools targeting readers of lysine methylation.
1. Curr Opin Chem Biol - published March 2, 2023
2. Ortiz G, Kutateladze TG, Fujimori DG
Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors.
1. J Med Chem - published March 2, 2023
2. Lu W, Fan M, Ji W, Tse J, You I, Ficarro SB, Tavares I, Che J, Kim AY, Zhu X, Boghossian A, Rees MG, Ronan MM, Roth JA, Hinshaw SM, Nabet B, Corsello SM, Kwiatkowski N, Marto JA, Zhang T, Gray NS
MicroED Structure of a Protoglobin Reactive Carbene Intermediate.
1. J Am Chem Soc - published March 2, 2023
2. Danelius E, Porter NJ, Unge J, Arnold FH, Gonen T
CFTR function, pathology and pharmacology at single-molecule resolution.
1. Nature - published March 2, 2023
2. Levring J, Terry DS, Kilic Z, Fitzgerald G, Blanchard S, Chen J
Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor.
1. Gynecol Oncol - published March 2, 2023
2. McNamara B, Harold J, Manavella D, Bellone S, Mutlu L, Hartwich TMP, Zipponi M, Yang-Hartwich Y, Demirkiran C, Verzosa MSZ, Yang K, Choi J, Dong W, Buza N, Hui P, Altwerger G, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz PE, Burton EA, Inagaki H, Albers A, Zhang C, Bollag G, Schlessinger J, Santin AD
Structural Basis for Binding of Neutralizing Antibodies to Clostridioides difficile Binary Toxin.
1. J Bacteriol - published March 2, 2023
2. Goldsmith JA, Dewar V, Hermand P, Blais N, McLellan JS
Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state.
1. Elife - published March 2, 2023
2. Padavannil A, Murari A, Rhooms SK, Owusu-Ansah E, Letts JA
From primordial clocks to circadian oscillators.
1. Nature - published March 2, 2023
2. Pitsawong W, Pádua RAP, Grant T, Hoemberger M, Otten R, Bradshaw N, Grigorieff N, Kern D
High Accuracy Prediction of PROTAC Complex Structures.
1. J Am Chem Soc - published March 2, 2023
2. Ignatov M, Jindal A, Kotelnikov S, Beglov D, Posternak G, Tang X, Maisonneuve P, Poda G, Batey RA, Sicheri F, Whitty A, Tonge PJ, Vajda S, Kozakov D
Author Correction: Multi-micron crisscross structures grown from DNA-origami slats.
1. Nat Nanotechnol - published March 2, 2023
2. Wintersinger CM, Minev D, Ershova A, Sasaki HM, Gowri G, Berengut JF, Corea-Dilbert FE, Yin P, Shih WM
Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies.
1. Proc Natl Acad Sci U S A - published March 2, 2023
2. Williamson LE, Bandyopadhyay A, Bailey K, Sirohi D, Klose T, Julander JG, Kuhn RJ, Crowe JE Jr
Clinical PARP inhibitors allosterically induce PARP2 retention on DNA.
1. Sci Adv - published March 2, 2023
2. Langelier MF, Lin X, Zha S, Pascal JM
Reverse vaccinology-based identification of a novel surface lipoprotein that is an effective vaccine antigen against bovine infections caused by Pasteurella multocida.
1. PLoS Pathog - published March 2, 2023
2. Islam EA, Fegan JE, Tefera TA, Curran DM, Waeckerlin RC, Ng D, Ahn SK, Lai CHR, Nguyen QH, Shah M, Tesfaw L, Adamu K, Medhin WW, Legesse A, Deresse G, Getachew B, Rawlyk N, Evans B, Potter A, Schryvers AB, Gray-Owen SD, Moraes TF
HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.
1. Elife - published March 2, 2023
2. Scinicariello S, Soderholm A, Schäfer M, Shulkina A, Schwartz I, Hacker K, Gogova R, Kalis R, Froussios K, Budroni V, Bestehorn A, Clausen T, Kovarik P, Zuber J, Versteeg GA
A naturally occurring mini-alanyl-tRNA synthetase.
1. Commun Biol - published March 2, 2023
2. Antika TR, Chrestella DJ, Tseng YK, Yeh YH, Hsiao CD, Wang CC
Structural basis of bacteriophage T5 infection trigger and E. coli cell wall perforation.
1. Sci Adv - published March 2, 2023
2. Linares R, Arnaud CA, Effantin G, Darnault C, Epalle NH, Boeri Erba E, Schoehn G, Breyton C
Visualizing the coordination of apurinic/apyrimidinic endonuclease (APE1) and DNA Polymerase β during Base Excision Repair.
1. J Biol Chem - published March 2, 2023
2. Fairlamb MS, Spies M, Washington TM, Freudenthal BD
Structure and RAF-family kinase isoform selectivity of Type II RAF inhibitors tovorafenib and naporafenib.
1. J Biol Chem - published March 2, 2023
2. Tkacik E, Li K, Gonzalez-Del Pino G, Ha BH, Vinals J, Park E, Beyett TS, Eck MJ
Exploration of O-GlcNAc-transferase (OGT) glycosylation sites reveals a target sequence compositional bias.
1. J Biol Chem - published March 2, 2023
2. Chong PA, Nosella M, Vanama M, Ruiz-Arduengo R, Forman-Kay JD
Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics.
1. Nat Commun - published March 2, 2023
2. Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH
Endoscopic ultrasound diagnosis system based on deep learning in images capture and segmentation training of solid pancreatic masses.
1. Med Phys - published March 2, 2023
2. Tang A, Gong P, Fang N, Ye M, Hu S, Liu J, Wang W, Gao K, Wang X, Tian L
The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module.
1. Biochim Biophys Acta Gene Regul Mech - published March 2, 2023
2. Haile ST, Rahman S, Fields JK, Orsburn BC, Bumpus NN, Wolberger C
Specific regulation of BACH1 by the hotspot mutant p53(R175H) reveals a distinct gain-of-function mechanism.
1. Nat Cancer - published March 2, 2023
2. Su Z, Kon N, Yi J, Zhao H, Zhang W, Tang Q, Li H, Kobayashi H, Li Z, Duan S, Liu Y, Olive KP, Zhang Z, Honig B, Manfredi JJ, Rustgi AK, Gu W
Antigenic mapping and functional characterization of human new world hantavirus neutralizing antibodies.
1. Elife - published March 2, 2023
2. Engdahl TB, Binshtein E, Brocato RL, Kuzmina NA, Principe LM, Kwilas SA, Kim RK, Chapman NS, Porter MS, Guardado-Calvo P, Rey FA, Handal LS, Diaz SM, Zagol-Ikapitte IA, Tran MH, McDonald WH, Meiler J, Reidy JX, Trivette A, Bukreyev A, Hooper JW, Crowe JE Jr
Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives.
1. RSC Med Chem - published March 2, 2023
2. Nowak RP, Che J, Ferrao S, Kong NR, Liu H, Zerfas BL, Jones LH
Structural basis for Ca(V)α(2)δ:gabapentin binding.
1. Nat Struct Mol Biol - published March 2, 2023
2. Chen Z, Mondal A, Minor DL Jr
Structural and functional analysis of human pannexin 2 channel.
1. Nat Commun - published March 2, 2023
2. He Z, Zhao Y, Rau MJ, Fitzpatrick JAJ, Sah R, Hu H, Yuan P
Kinetic analysis of paramyxovirus-sialoglycan receptor interactions reveals virion motility.
1. PLoS Pathog - published March 2, 2023
2. Wu X, Goebbels M, Chao L, Wennekes T, van Kuppeveld FJM, de Vries E, de Haan CAM
Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.
1. Nat Commun - published March 2, 2023
2. Trastoy B, Du JJ, Cifuente JO, Rudolph L, García-Alija M, Klontz EH, Deredge D, Sultana N, Huynh CG, Flowers MW, Li C, Sastre DE, Wang LX, Corzana F, Mallagaray A, Sundberg EJ, Guerin ME
Trapoxin A Analogue as a Selective Nanomolar Inhibitor of HDAC11.
1. ACS Chem Biol - published March 2, 2023
2. Ho TT, Peng C, Seto E, Lin H
Effect of Passive Administration of Monoclonal Antibodies Recognizing Simian Immunodeficiency Virus (SIV) V2 in CH59-Like Coil/Helical or β-Sheet Conformations on Time of SIV(mac251) Acquisition.
1. J Virol - published March 2, 2023
2. Stamos JD, Rahman MA, Gorini G, Silva de Castro I, Becerra-Flores M, Van Wazer DJ, N'Guessan KF, Clark NM, Bissa M, Gutowska A, Mason RD, Kim J, Rao M, Roederer M, Paquin-Proulx D, Evans DT, Cicala C, Arthos J, Kwong PD, Zhou T, Cardozo T, Franchini G
Contribution of calcium ligands in substrate binding and product release in the Acetovibrio thermocellus glycoside hydrolase family 9 cellulase CelR.
1. J Biol Chem - published March 2, 2023
2. Kuch NJ, Kutschke ME, Parker A, Bingman CA, Fox BG
Being Black in biophysics.
1. Biophys J - published March 2, 2023
2. Robertson GA, Clemons WM Jr, Griffith TN
A thermosensitive PCNA allele underlies an Ataxia Telangiectasia-like disorder.
1. J Biol Chem - published March 2, 2023
2. Magrino J, Munford V, Martins DJ, Homma TK, Page B, Gaubitz C, Freire BL, Lerario AM, Vilar JB, Amorin A, Leão EKE, Kok F, Menck CFM, Jorge AAL, Kelch BA
Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not for G-domain-mediated interactions.
1. Mol Cell - published March 2, 2023
2. Simanshu DK, Philips MR, Hancock JF
Revisiting focused ion beam scanning electron microcopy.
1. Trends Biochem Sci - published March 2, 2023
2. Marshall AG, Damo SA, Hinton A Jr
Structural basis for GSDMB pore formation and its targeting by IpaH7.8.
1. Nature - published March 2, 2023
2. Wang C, Shivcharan S, Tian T, Wright S, Ma D, Chang J, Li K, Song K, Xu C, Rathinam VA, Ruan J
Programmable protein delivery with a bacterial contractile injection system.
1. Nature - published March 2, 2023
2. Kreitz J, Friedrich MJ, Guru A, Lash B, Saito M, Macrae RK, Zhang F
Characterization of the rotavirus assembly pathway in situ using cryoelectron tomography.
1. Cell Host Microbe - published March 2, 2023
2. Shah PNM, Gilchrist JB, Forsberg BO, Burt A, Howe A, Mosalaganti S, Wan W, Radecke J, Chaban Y, Sutton G, Stuart DI, Boyce M
ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas.
1. Cell Chem Biol - published March 2, 2023
2. Jiang B, Weinstock DM, Donovan KA, Sun HW, Wolfe A, Amaka S, Donaldson NL, Wu G, Jiang Y, Wilcox RA, Fischer ES, Gray NS, Wu W
Ad26.COV2.S and SARS-CoV-2 spike protein ferritin nanoparticle vaccine protect against SARS-CoV-2 Omicron BA.5 challenge in macaques.
1. Cell Rep Med - published March 2, 2023
2. Yu J, Thomas PV, Sciacca M, Wu C, Liu J, He X, Miller J, Hachmann NP, Surve N, McMahan K, Jacob-Dolan C, Powers O, Hall K, Barrett J, Hope D, Mazurek CR, Murdza T, Chang WC, Golub E, Rees PA, Peterson CE, Hajduczki A, Chen WH, Martinez EJ, Hussin E, Lange C, Gong H, Matyas GR, Rao M, Suthar M, Boursiquot M, Cook A, Pessaint L, Lewis MG, Andersen H, Bolton DL, Michael NL, Joyce MG, Modjarrad K, Barouch DH
Diagnostic TR-FRET assays for detection of antibodies in patient samples.
1. Cell Rep Methods - published March 2, 2023
2. Yue H, Nowak RP, Overwijn D, Payne NC, Fischinger S, Atyeo C, Lam EC, St Denis K, Brais LK, Konishi Y, Sklavenitis-Pistofidis R, Baden LR, Nilles EJ, Karlson EW, Yu XG, Li JZ, Woolley AE, Ghobrial IM, Meyerhardt JA, Balazs AB, Alter G, Mazitschek R, Fischer ES
The Endoplasmic Reticulum and the Fidelity of Nascent Protein Localization.
1. Cold Spring Harb Perspect Biol - published March 1, 2023
2. McKenna MJ, Shao S
The impact of stage-related features in melanoma recurrence prediction: A machine learning approach.
1. JAAD Int - published March 1, 2023
2. Wan G, Leung B, Nguyen N, DeSimone MS, Liu F, Choi MS, Ho D, Laucks V, Duey S, Sullivan RJ, Boland GM, LeBoeuf NR, Liu D, Gusev A, Kwatra SG, Sorger PK, Yu KH, Semenov YR
Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.
1. Life Sci Alliance - published March 1, 2023
2. Lian J, Walker RG, D'Amico A, Vujic A, Mills MJ, Messemer KA, Mendello KR, Goldstein JM, Leacock KA, Epp S, Stimpfl EV, Thompson TB, Wagers AJ, Lee RT
RSCanner: rapid assessment and visualization of RNA structure content.
1. Bioinformatics - published March 1, 2023
2. Mahadeshwar G, Araujo Tavares RC, Wan H, Perry Z, Pyle AM
Crocodile defensin (CpoBD13) antifungal activity via pH-dependent phospholipid targeting and membrane disruption.
1. Nat Commun - published March 1, 2023
2. Williams SA, Lay FT, Bindra GK, Banjara S, Poon IKH, Phan TK, Kvansakul M, Hulett MD
A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.
1. Sci Transl Med - published March 1, 2023
2. Castelli LM, Lin YH, Sanchez-Martinez A, Gül A, Mohd Imran K, Higginbottom A, Upadhyay SK, Márkus NM, Rua Martins R, Cooper-Knock J, Montmasson C, Cohen R, Walton A, Bauer CS, De Vos KJ, Mead RJ, Azzouz M, Dominguez C, Ferraiuolo L, Shaw PJ, Whitworth AJ, Hautbergue GM
Coordination of bacterial cell wall and outer membrane biosynthesis.
1. Nature - published March 1, 2023
2. Hummels KR, Berry SP, Li Z, Taguchi A, Min JK, Walker S, Marks DS, Bernhardt TG
Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function.
1. Nat Commun - published March 1, 2023
2. Hor L, Pilapitiya A, McKenna JA, Panjikar S, Anderson MA, Desvaux M, Paxman JJ, Heras B
Structural basis of Janus kinase trans-activation.
1. Cell Rep - published March 1, 2023
2. Caveney NA, Saxton RA, Waghray D, Glassman CR, Tsutsumi N, Hubbard SR, Garcia KC
20 years of crystal hits: progress and promise in ultrahigh-throughput crystallization screening.
1. Acta Crystallogr D Struct Biol - published March 1, 2023
2. Lynch ML, Snell ME, Potter SA, Snell EH, Bowman SEJ
Structure of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface.
1. Open Biol - published March 1, 2023
2. Zahm JA, Jenni S, Harrison SC
A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation.
1. Proc Natl Acad Sci U S A - published March 1, 2023
2. Pietz HL, Abbas A, Johnson ZL, Oldham ML, Suga H, Chen J
Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination.
1. Proc Natl Acad Sci U S A - published March 1, 2023
2. Tsutsumi N, Hwang S, Waghray D, Hansen S, Jude KM, Wang N, Miao Y, Glassman CR, Caveney NA, Janda CY, Hannoush RN, Garcia KC
Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader.
1. Angew Chem Int Ed Engl - published March 1, 2023
2. Teng M, Jiang J, Wang ES, Geng Q, Toenjes ST, Donovan KA, Mageed N, Yue H, Nowak RP, Wang J, Manz TD, Fischer ES, Cantley LC, Gray NS
Molecular mechanism of biased signaling at the kappa opioid receptor.
1. Nat Commun - published March 1, 2023
2. El Daibani A, Paggi JM, Kim K, Laloudakis YD, Popov P, Bernhard SM, Krumm BE, Olsen RHJ, Diberto J, Carroll FI, Katritch V, Wünsch B, Dror RO, Che T
Efficacy of osimertinib in patients with lung cancer positive for uncommon EGFR exon 19 deletion mutations.
1. Clin Cancer Res - published March 1, 2023
2. Grant MJ, Aredo JV, Starrett JH, Stockhammer P, van Alderwerelt van Rosenburgh IK, Wurtz A, Piper-Valillo AJ, Piotrowska Z, Falcon C, Yu HA, Aggarwal C, Scholes D, Patil T, Nguyen C, Phadke M, Li FY, Neal J, Lemmon MA, Walther Z, Politi K, Goldberg SB
Interaction with the carboxy-terminal tip of SSB is critical for RecG function in E. coli.
1. Nucleic Acids Res - published March 1, 2023
2. Bonde NJ, Henry C, Wood EA, Cox MM, Keck JL
Interpreting the Evolutionary Echoes of a Protein Complex Essential for Inner-Ear Mechanosensation.
1. Mol Biol Evol - published March 1, 2023
2. Nisler CR, Narui Y, Scheib E, Choudhary D, Bowman JD, Mandayam Bharathi H, Lynch VJ, Sotomayor M
Author Correction: An E1-E2 fusion protein primes antiviral immune signalling in bacteria.
1. Nature - published March 1, 2023
2. Ledvina HE, Ye Q, Gu Y, Sullivan AE, Quan Y, Lau RK, Zhou H, Corbett KD, Whiteley AT
Distinct In Vitro and In Vivo Neutralization Profiles of Monoclonal Antibodies Elicited by the Receptor Binding Domain of the Ancestral SARS-CoV-2.
1. J Med Virol - published March 1, 2023
2. Kwon HJ, Zhang J, Kosikova M, Tang W, Ortega-Rodriguez U, Peng H, Meseda CA, Pedro CL, Schmeisser F, Lu J, Kang I, Zhou B, Davis CT, Wentworth DE, Chen WH, Shriver MC, Barnes RS, Pasetti MF, Weir JP, Chen B, Xie H
Selection of HIV-1 for resistance to fifth generation protease inhibitors reveals two independent pathways to high-level resistance.
1. Elife - published March 1, 2023
2. Spielvogel E, Lee SK, Zhou S, Lockbaum GJ, Henes M, Sondgeroth A, Kosovrasti K, Nalivaika EA, Ali A, Yilmaz NK, Schiffer CA, Swanstrom R
Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction.
1. Cell Rep - published March 1, 2023
2. Chen JY, Hug C, Reyes J, Tian C, Gerosa L, Fröhlich F, Ponsioen B, Snippert HJG, Spencer SL, Jambhekar A, Sorger PK, Lahav G
Enzymatic Spin-Labeling of Protein N- and C-Termini for Electron Paramagnetic Resonance Spectroscopy.
1. Bioconjug Chem - published March 1, 2023
2. Dunleavy R, Chandrasekaran S, Crane BR
A protocol for capturing RNA-sensing innate immune receptors in multiple conformations by single-particle cryo-EM.
1. STAR Protoc - published March 1, 2023
2. Wang W, Fedorova O, Pyle AM
Christopher T. Walsh: A Prolific Scientist, Effective Academic Leader, and Responsive Mentor.
1. ACS Chem Biol - published March 1, 2023
2. Lin H
Lactate regulates cell cycle by remodeling the anaphase promoting complex.
1. Nature - published March 1, 2023
2. Liu W, Wang Y, Bozi LHM, Fischer P, Jedrychowski MP, Xiao H, Wu T, Darabedian N, He X, Mills EL, Burger N, Shin S, Reddy A, Sprenger HG, Tran N, Winther S, Hinshaw SM, Shen J, Seo HS, Song K, Xu AZ, Sebastian L, Zhao J, Dhe-Paganon S, Che J, Gygi SP, Arthanari H, Chouchani ET
MEN1 mutations mediate clinical resistance to menin inhibition.
1. Nature - published March 1, 2023
2. Perner F, Stein EM, Wenge DV, Singh S, Kim J, Apazidis A, Rahnamoun H, Anand D, Marinaccio C, Hatton C, Wen Y, Stone RM, Schaller D, Mowla S, Xiao W, Gamlen HA, Stonestrom AJ, Persaud S, Ener E, Cutler JA, Doench JG, McGeehan GM, Volkamer A, Chodera JD, Nowak RP, Fischer ES, Levine RL, Armstrong SA, Cai SF
Artificial intelligence for drug discovery: Resources, methods, and applications.
1. Mol Ther Nucleic Acids - published March 1, 2023
2. Chen W, Liu X, Zhang S, Chen S
Structural basis of odorant recognition by a human odorant receptor.
1. Nature - published March 1, 2023
2. Billesbølle CB, de March CA, van der Velden WJC, Ma N, Tewari J, Del Torrent CL, Li L, Faust B, Vaidehi N, Matsunami H, Manglik A
A hybrid structure determination approach to investigate the druggability of the nucleocapsid protein of SARS-CoV-2.
1. Nucleic Acids Res - published March 1, 2023
2. Padroni G, Bikaki M, Novakovic M, Wolter AC, Rüdisser SH, Gossert AD, Leitner A, Allain FH
Indirect Enrichment of Desirable, but Less Fit Phenotypes, from a Synthetic Microbial Community Using Microdroplet Confinement.
1. ACS Synth Biol - published March 1, 2023
2. Ganiga Prabhakar R, Fan G, Alnahhas RN, Hirning AJ, Bennett MR, Shamoo Y
Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma.
1. Nat Med - published March 1, 2023
2. Larrayoz M, Garcia-Barchino MJ, Celay J, Etxebeste A, Jimenez M, Perez C, Ordoñez R, Cobaleda C, Botta C, Fresquet V, Roa S, Goicoechea I, Maia C, Lasaga M, Chesi M, Bergsagel PL, Larrayoz MJ, Calasanz MJ, Campos-Sanchez E, Martinez-Cano J, Panizo C, Rodriguez-Otero P, Vicent S, Roncador G, Gonzalez P, Takahashi S, Katz SG, Walensky LD, Ruppert SM, Lasater EA, Amann M, Lozano T, Llopiz D, Sarobe P, Lasarte JJ, Planell N, Gomez-Cabrero D, Kudryashova O, Kurilovich A, Revuelta MV, Cerchietti L, Agirre X, San Miguel J, Paiva B, Prosper F, Martinez-Climent JA
The functional evolution of architecturally different plant geranyl diphosphate synthases from geranylgeranyl diphosphate synthase.
1. Plant Cell - published March 1, 2023
2. Song S, Jin R, Chen Y, He S, Li K, Tang Q, Wang Q, Wang L, Kong M, Dudareva N, Smith BJ, Zhou F, Lu S
Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics.
1. Elife - published March 1, 2023
2. Braet SM, Buckley TSC, Venkatakrishnan V, Dam KA, Bjorkman PJ, Anand GS
A massive machine regulates cell death.
1. Science - published March 1, 2023
2. Mace PD, Day CL
Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation.
1. J Am Chem Soc - published March 1, 2023
2. Wang ZA, Markert JW, Whedon SD, Yapa Abeywardana M, Lee K, Jiang H, Suarez C, Lin H, Farnung L, Cole PA
Cryo-EM structures of anti-malarial antibody L9 with circumsporozoite protein reveal trimeric L9 association and complete 27-residue epitope.
1. Structure - published March 1, 2023
2. Tripathi P, Bender MF, Lei H, Da Silva Pereira L, Shen CH, Bonilla B, Dillon M, Ou L, Pancera M, Wang LT, Zhang B, Batista FD, Idris AH, Seder RA, Kwong PD
Monitoring prothrombin activation in plasma through loss of FRET.
1. J Thromb Haemost - published March 1, 2023
2. Stojanovski BM, Di Cera E
Heterologous Assembly of Pleomorphic Bacterial Microcompartment Shell Architectures Spanning the Nano- to Microscale.
1. Adv Mater - published March 1, 2023
2. Ferlez BH, Kirst H, Greber BJ, Nogales E, Sutter M, Kerfeld CA
PrePPI: A structure informed proteome-wide database of protein-protein interactions.
1. J Mol Biol - published March 1, 2023
2. Petrey D, Zhao H, Trudeau S, Murray D, Honig B
Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein.
1. Nat Commun - published March 1, 2023
2. Byrne PO, Fisher BE, Ambrozak DR, Blade EG, Tsybovsky Y, Graham BS, McLellan JS, Loomis RJ
SARS-CoV-2 spike-ferritin-nanoparticle adjuvanted with ALFQ induces long-lived plasma cells and cross-neutralizing antibodies.
1. NPJ Vaccines - published March 1, 2023
2. Shrivastava S, Carmen JM, Lu Z, Basu S, Sankhala RS, Chen WH, Nguyen P, Chang WC, King J, Corbitt C, Mayer S, Bolton JS, Anderson A, Swafford I, Terriquez GD, Trinh HV, Kim J, Jobe O, Paquin-Proulx D, Matyas GR, Gromowski GD, Currier JR, Bergmann-Leitner E, Modjarrad K, Michael NL, Joyce MG, Malloy AMW, Rao M
Consolidated bioprocessing of plant biomass to polyhydroxyalkanoate by co-culture of Streptomyces sp. SirexAA-E and Priestia megaterium.
1. Bioresour Technol - published March 1, 2023
2. Kumar V, Fox BG, Takasuka TE
Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation.
1. iScience - published March 1, 2023
2. Mishra S, Ma J, McKoy D, Sasaki M, Farinelli F, Page RC, Ranek MJ, Zachara N, Kass DA
A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase.
1. Mol Ther Oncolytics - published March 1, 2023
2. Diluvio G, Kelley TT, Lahiry M, Alvarez-Trotta A, Kolb EM, Shersher E, Astudillo L, Kovall RA, Schürer SC, Capobianco AJ
High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography.
1. J Vis Exp - published March 1, 2023
2. Budziszewski GR, Snell ME, Wright TR, Lynch ML, Bowman SEJ
Docking cholesterol to integral membrane proteins with Rosetta.
1. PLoS Comput Biol - published March 1, 2023
2. Marlow B, Kuenze G, Meiler J, Koehler Leman J
An Improved Technique for Trimethylamine Detection in Animal-Derived Medicine by Headspace Gas Chromatography-Tandem Quadrupole Mass Spectrometry.
1. J Vis Exp - published March 1, 2023
2. Ye H, Liu X, Huang H, Huang L, Bao Y, Ma H, Lin J, Bao X, Zhang D, Xu R
Genome-Wide Analysis of Antigen 43 (Ag43) Variants: New Insights in Their Diversity, Distribution and Prevalence in Bacteria.
1. Int J Mol Sci - published March 1, 2023
2. Ageorges V, Wawrzyniak I, Ruiz P, Bicep C, Zorgani MA, Paxman JJ, Heras B, Henderson IR, Leroy S, Bailly X, Sapountzis P, Peyretaillade E, Desvaux M
Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses.
1. Viruses - published March 1, 2023
2. Zvornicanin SN, Shaqra AM, Huang QJ, Ornelas E, Moghe M, Knapp M, Moquin S, Dovala D, Schiffer CA, Kurt Yilmaz N