Member Publications

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145 Member Publications for April 2023

Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism.
1. bioRxiv - published April 27, 2023
2. Caveney NA, Tsutsumi N, Garcia KC
Glycan masking in vaccine design: Targets, immunogens and applications.
1. Front Immunol - published April 10, 2023
2. Martina CE, Crowe JE Jr, Meiler J
Convergent antibody responses are associated with broad neutralization of hepatitis C virus.
1. Front Immunol - published April 10, 2023
2. Skinner NE, Ogega CO, Frumento N, Clark KE, Yegnasubramanian S, Schuebel K, Meyers J, Gupta A, Wheelan S, Cox AL, Crowe JE Jr, Ray SC, Bailey JR
GCP16 stabilizes the DHHC9 subfamily of protein acyltransferases through a conserved C-terminal cysteine motif.
1. Front Physiol - published April 10, 2023
2. Nguyen PL, Greentree WK, Kawate T, Linder ME
Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2.
1. Commun Biol - published April 8, 2023
2. Svilenov HL, Delhommel F, Siebenmorgen T, Rührnößl F, Popowicz GM, Reiter A, Sattler M, Brockmeyer C, Buchner J
Development of a Kinetic ELISA and Reactive B Cell Frequency Assay to Detect Respiratory Syncytial Virus Pre-Fusion F Protein-Specific Immune Responses in Infants.
1. J Pediatric Infect Dis Soc - published April 8, 2023
2. Rolsma SL, Yoder SM, Nargi RS, Brady E, Jimenez-Truque N, Thomsen I, Kontos M, Carnahan RH, Sutton RE, Armstrong E, Dally L, Crowe JE, Edwards KM, Creech CB
Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma.
1. Cancer Cell - published April 8, 2023
2. Gaglia G, Burger ML, Ritch CC, Rammos D, Dai Y, Crossland GE, Tavana SZ, Warchol S, Jaeger AM, Naranjo S, Coy S, Nirmal AJ, Krueger R, Lin JR, Pfister H, Sorger PK, Jacks T, Santagata S
A Practical Guide to Graduate School Interviewing for Historically Excluded Individuals.
1. Am J Physiol Heart Circ Physiol - published April 7, 2023
2. Ransey E, Brookens S, Beasley HK, Marshall A, Marlin BJ, Rodriguez-Aliaga P, Headley CA, Wanjalla C, Vazquez AD, Murray S, Damo S, Taabazuing CY, Hinton A Jr
Immunological characterization of a VIR protein family member (VIR-14) in Plasmodium vivax-infected subjects from different epidemiological regions in Africa and South America.
1. PLoS Negl Trop Dis - published April 7, 2023
2. Fantin RF, Coelho CH, Berhe AD, Magalhães LMD, Pereira DB, Salinas ND, Tolia NH, Amaratunga C, Suon S, Sagara I, Narum DL, Fujiwara RT, Abejon C, Campos-Neto A, Duffy PE, Bueno LL
Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model.
1. NPJ Vaccines - published April 7, 2023
2. Ludwig J, Scally SW, Costa G, Hoffmann S, Murugan R, Lossin J, Prieto K, Obraztcova A, Lobeto N, Franke-Fayard B, Janse CJ, Lebas C, Collin N, Binter S, Kellam P, Levashina EA, Wardemann H, Julien JP
Topical treatment of tea saponin stabilized silybin nanocrystal gel reduced oxidative stress in UV-induced skin damage.
1. Biochem Biophys Res Commun - published April 7, 2023
2. Gu H, Liu X, Chen P, Shi M, Chen L, Li X
Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity.
1. Haematologica - published April 6, 2023
2. O'Brien C, Ling T, Berman JM, Culp-Hill R, Reisz JA, Rondeau V, Jahangiri S, St-Germain J, Macwan V, Astori A, Zeng A, Hong JY, Li M, Yang M, Jana S, Gamboni F, Tsao E, Liu W, Dick JE, Lin H, Melnick A, Tikhonova A, Arruda A, Minden MD, Raught B, D'Alessandro A, Jones CL
Structure of the R2 non-LTR retrotransposon initiating target-primed reverse transcription.
1. Science - published April 6, 2023
2. Wilkinson ME, Frangieh CJ, Macrae RK, Zhang F
Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA.
1. Mol Cell - published April 6, 2023
2. Paget M, Cadena C, Ahmad S, Wang HT, Jordan TX, Kim E, Koo B, Lyons SM, Ivanov P, tenOever B, Mu X, Hur S
Two heads are better than one: Cooperation of two CAPS domains in membrane binding.
1. Structure - published April 6, 2023
2. Dong G
ZART: A novel multiresolution reconstruction algorithm with motion-blur correction for single particle analysis.
1. J Mol Biol - published April 6, 2023
2. Herreros D, Kiska J, Ramirez E, Filipovic J, Carazo JM, Sorzano COS
Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes.
1. Cell Rep - published April 6, 2023
2. Chen EC, Gilchuk P, Zost SJ, Ilinykh PA, Binshtein E, Huang K, Myers L, Bonissone S, Day S, Kona CR, Trivette A, Reidy JX, Sutton RE, Gainza C, Diaz S, Williams JK, Selverian CN, Davidson E, Saphire EO, Doranz BJ, Castellana N, Bukreyev A, Carnahan RH, Crowe JE Jr
A Lightweight AlCrTiV(0.5)Cu(x) High-Entropy Alloy with Excellent Corrosion Resistance.
1. Materials (Basel) - published April 6, 2023
2. Peng Z, Li B, Luo Z, Chen X, Tang Y, Yang G, Gong P
HiBiT-SpyTag: A Minimal Tag for Covalent Protein Capture and Degrader Development.
1. ACS Chem Biol - published April 5, 2023
2. Tsang T, Huerta F, Liu Y, Che J, Metivier RJ, Ferrao S, Donovan KA, Jones LH, Zerfas BL, Nowak RP
Cryo-EM structure of the transposon-associated TnpB enzyme.
1. Nature - published April 5, 2023
2. Nakagawa R, Hirano H, Omura SN, Nety S, Kannan S, Altae-Tran H, Yao X, Sakaguchi Y, Ohira T, Wu WY, Nakayama H, Shuto Y, Tanaka T, Sano FK, Kusakizako T, Kise Y, Itoh Y, Dohmae N, van der Oost J, Suzuki T, Zhang F, Nureki O
The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells.
1. Nature - published April 5, 2023
2. Sen Santara S, Lee DJ, Crespo Â, Hu JJ, Walker C, Ma X, Zhang Y, Chowdhury S, Meza-Sosa KF, Lewandrowski M, Zhang H, Rowe M, McClelland A, Wu H, Junqueira C, Lieberman J
mRNA decoding in human is kinetically and structurally distinct from bacteria.
1. Nature - published April 5, 2023
2. Holm M, Natchiar SK, Rundlet EJ, Myasnikov AG, Watson ZL, Altman RB, Wang HY, Taunton J, Blanchard SC
mRNA recognition and packaging by the human transcription-export complex.
1. Nature - published April 5, 2023
2. Pacheco-Fiallos B, Vorländer MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Progress in vaccine development for infectious diseases-a Keystone Symposia report.
1. Ann N Y Acad Sci - published April 5, 2023
2. Cable J, Graham BS, Koup RA, Seder RA, Karikó K, Pardi N, Barouch DH, Sharma B, Rauch S, Nachbagauer R, Forsell MNE, Schotsaert M, Ellebedy AH, Loré K, Irvine DJ, Pilkington E, Tahtinen S, Thompson EA, Feraoun Y, King NP, Saunders K, Alter G, Moin SM, Sliepen K, Hedestam GBK, Wardemann H, Pulendran B, Doria-Rose NA, He WT, Juno JA, Ataca S, Wheatley AK, McLellan JS, Walker LM, Lederhofer J, Lindesmith LC, Wille H, Hotez PJ, Bekker LG
Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control.
1. Cell Rep - published April 5, 2023
2. Gao Y, Khan YA, Mo W, White KI, Perkins M, Pfuetzner RA, Trapani JG, Brunger AT, Nicolson T
Quantitative reconstitution of yeast RNA processing bodies.
1. Proc Natl Acad Sci U S A - published April 4, 2023
2. Currie SL, Xing W, Muhlrad D, Decker CJ, Parker R, Rosen MK
A general mechanism for transcription bubble nucleation in bacteria.
1. Proc Natl Acad Sci U S A - published April 4, 2023
2. Mueller AU, Chen J, Wu M, Chiu C, Nixon BT, Campbell EA, Darst SA
Structural insights into the multifunctionality of rabies virus P3 protein.
1. Proc Natl Acad Sci U S A - published April 4, 2023
2. Sethi A, Rawlinson SM, Dubey A, Ang CS, Choi YH, Yan F, Okada K, Rozario AM, Brice AM, Ito N, Williamson NA, Hatters DM, Bell TDM, Arthanari H, Moseley GW, Gooley PR
Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na(V)1.7.
1. Proc Natl Acad Sci U S A - published April 4, 2023
2. Wisedchaisri G, Gamal El-Din TM, Zheng N, Catterall WA
Structural insights into plasmalemma vesicle-associated protein (PLVAP): Implications for vascular endothelial diaphragms and fenestrae.
1. Proc Natl Acad Sci U S A - published April 4, 2023
2. Chang TH, Hsieh FL, Gu X, Smallwood PM, Kavran JM, Gabelli SB, Nathans J
CRISPR-clear imaging of melanin-rich B16-derived solid tumors.
1. Commun Biol - published April 4, 2023
2. Schubert R, Bae T, Simic B, Smith SN, Park SH, Nagy-Davidescu G, Gradinaru V, Plückthun A, Hur JK
The Melolontha melolontha entomopoxvirus fusolin protein is a chitin-active lytic polysaccharide monooxygenase that displays extreme stability.
1. FEBS Lett - published April 4, 2023
2. Loose JSM, Boudes M, Bergoin M, Coulibaly F, Vaaje-Kolstad G
Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase.
1. Nucleic Acids Res - published April 4, 2023
2. Tomar R, Minko IG, Sharma P, Kellum AH, Lei L, Harp JM, Iverson TM, Lloyd RS, Egli M, Stone MP
Multiplatform analyses reveal distinct drivers of systemic pathogenesis in adult versus pediatric severe acute COVID-19.
1. Nat Commun - published April 4, 2023
2. Druzak S, Iffrig E, Roberts BR, Zhang T, Fibben KS, Sakurai Y, Verkerke HP, Rostad CA, Chahroudi A, Schneider F, Wong AKH, Roberts AM, Chandler JD, Kim SO, Mosunjac M, Mosunjac M, Geller R, Albizua I, Stowell SR, Arthur CM, Anderson EJ, Ivanova AA, Ahn J, Liu X, Maner-Smith K, Bowen T, Paiardini M, Bosinger SE, Roback JD, Kulpa DA, Silvestri G, Lam WA, Ortlund EA, Maier CL
Aberrant phase separation: linking IDR mutations to disease.
1. Cell Res - published April 4, 2023
2. Ahmed R, Forman-Kay JD
Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies.
1. PLoS Comput Biol - published April 4, 2023
2. Zitzmann C, Dächert C, Schmid B, van der Schaar H, van Hemert M, Perelson AS, van Kuppeveld FJM, Bartenschlager R, Binder M, Kaderali L
Sparse pseudocontact shift NMR data obtained from a non-canonical amino acid-linked lanthanide tag improves integral membrane protein structure prediction.
1. J Biomol NMR - published April 4, 2023
2. Ledwitch KV, Künze G, McKinney JR, Okwei E, Larochelle K, Pankewitz L, Ganguly S, Darling HL, Coin I, Meiler J
An interaction between β'-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling.
1. J Cell Biol - published April 3, 2023
2. Xie B, Guillem C, Date SS, Cohen CI, Jung C, Kendall AK, Best JT, Graham TR, Jackson LP
PDC: a highly compact file format to store protein 3D coordinates.
1. Database (Oxford) - published April 3, 2023
2. Zhang C, Pyle AM
Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR): A Targeted Protein Degradation Toolbox.
1. ACS Synth Biol - published April 3, 2023
2. Siepe DH, Picton LK, Garcia KC
Mobile genetic element-encoded putative DNA primases composed of A-family polymerase-SSB pairs.
1. Front Mol Biosci - published April 3, 2023
2. Rice PA
SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.
1. Cell Rep - published April 3, 2023
2. Zhou H, Feng W, Yu J, Shafiq TA, Paulo JA, Zhang J, Luo Z, Gygi SP, Moazed D
A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication.
1. RSC Adv - published April 3, 2023
2. Han H, Gracia AV, Røise JJ, Boike L, Leon K, Schulze-Gahmen U, Stentzel MR, Bajaj T, Chen D, Li IC, He M, Behrouzi K, Khodabakhshi Z, Nomura DK, Mofrad MRK, Kumar GR, Ott M, Murthy N
Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses.
1. Cell Rep - published April 3, 2023
2. Kassardjian A, Sun E, Sookhoo J, Muthuraman K, Boligan KF, Kucharska I, Rujas E, Jetha A, Branch DR, Babiuk S, Barber B, Julien JP
NMR-Metabolomics Reveals a Metabolic Shift after Surgical Resection of Non-Small Cell Lung Cancer.
1. Cancers (Basel) - published April 3, 2023
2. Derveaux E, Geubbelmans M, Criel M, Demedts I, Himpe U, Tournoy K, Vercauter P, Johansson E, Valkenborg D, Vanhove K, Mesotten L, Adriaensens P, Thomeer M
Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power.
1. Chemistry - published April 2, 2023
2. Hobbs KF, Propp J, Vance NR, Kalenkiewicz A, Witkin KR, Spies MA
RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription.
1. Sci Adv - published April 2, 2023
2. Blatter M, Meylan C, Cléry A, Giambruno R, Nikolaev Y, Heidecker M, Solanki JA, Diaz MO, Gabellini D, Allain FH
Export of Diverse and Bioactive Small Proteins through a Type I Secretion System.
1. Appl Environ Microbiol - published April 2, 2023
2. Kim SY, Parker JK, Gonzalez-Magaldi M, Telford MS, Leahy DJ, Davies BW
Human immune and gut microbial parameters associated with inter-individual variations in COVID-19 mRNA vaccine-induced immunity.
1. Commun Biol - published April 2, 2023
2. Hirota M, Tamai M, Yukawa S, Taira N, Matthews MM, Toma T, Seto Y, Yoshida M, Toguchi S, Miyagi M, Mori T, Tomori H, Tamai O, Kina M, Sakihara E, Yamashiro C, Miyagi M, Tamaki K, Wolf M, Collins MK, Kitano H, Ishikawa H
Structural basis of centromeric cohesion protection.
1. Nat Struct Mol Biol - published April 2, 2023
2. García-Nieto A, Patel A, Li Y, Oldenkamp R, Feletto L, Graham JJ, Willems L, Muir KW, Panne D, Rowland BD
The relaxin receptor RXFP1 signals through a mechanism of autoinhibition.
1. Nat Chem Biol - published April 2, 2023
2. Erlandson SC, Rawson S, Osei-Owusu J, Brock KP, Liu X, Paulo JA, Mintseris J, Gygi SP, Marks DS, Cong X, Kruse AC
Molecular and functional properties of human Plasmodium falciparum CSP C-terminus antibodies.
1. EMBO Mol Med - published April 2, 2023
2. Oludada OE, Costa G, Burn Aschner C, Obraztsova AS, Prieto K, Canetta C, Hoffman SL, Kremsner PG, Mordmüller B, Murugan R, Julien JP, Levashina EA, Wardemann H
Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.
1. Gut - published April 2, 2023
2. Akhlaghpour M, Haritunians T, More SK, Thomas LS, Stamps DT, Dube S, Li D, Yang S, Landers CJ, Mengesha E, Hamade H, Murali R, Potdar AA, Wolf AJ, Botwin GJ, Khrom M, International IBD Genetics Consortium, Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Sartor RB, Xavier RJ, Brant SR, Cho JH, Duerr RH, Lazarev MG, Rioux JD, Schumm LP, Silverberg MS, Zaghiyan K, Fleshner P, Melmed GY, Vasiliauskas EA, Ha C, Rabizadeh S, Syal G, Bonthala NN, Ziring DA, Targan SR, Long MD, McGovern DPB, Michelsen KS
Encephalitis and poor neuronal death-mediated control of herpes simplex virus in human inherited RIPK3 deficiency.
1. Sci Immunol - published April 2, 2023
2. Liu Z, Garcia Reino EJ, Harschnitz O, Guo H, Chan YH, Khobrekar NV, Hasek ML, Dobbs K, Rinchai D, Materna M, Matuozzo D, Lee D, Bastard P, Chen J, Lee YS, Kim SK, Zhao S, Amin P, Lorenzo L, Seeleuthner Y, Chevalier R, Mazzola L, Gay C, Stephan JL, Milisavljevic B, Boucherit S, Rozenberg F, Perez de Diego R, Dix RD, Marr N, Béziat V, Cobat A, Aubart M, Abel L, Chabrier S, Smith GA, Notarangelo LD, Mocarski ES, Studer L, Casanova JL, Zhang SY
The nutrient-sensing GCN2 signaling pathway is essential for circadian clock function by regulating histone acetylation under amino acid starvation.
1. Elife - published April 2, 2023
2. Liu XL, Yang Y, Hu Y, Wu J, Han C, Lu Q, Gan X, Qi S, Guo J, He Q, Liu Y, Liu X
Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6.
1. Nat Commun - published April 2, 2023
2. Taha TY, Chen IP, Hayashi JM, Tabata T, Walcott K, Kimmerly GR, Syed AM, Ciling A, Suryawanshi RK, Martin HS, Bach BH, Tsou CL, Montano M, Khalid MM, Sreekumar BK, Renuka Kumar G, Wyman S, Doudna JA, Ott M
De novo variants implicate chromatin modification, transcriptional regulation, and retinoic acid signaling in syndromic craniosynostosis.
1. Am J Hum Genet - published April 2, 2023
2. Timberlake AT, McGee S, Allington G, Kiziltug E, Wolfe EM, Stiegler AL, Boggon TJ, Sanyoura M, Morrow M, Wenger TL, Fernandes EM, Caluseriu O, Persing JA, Jin SC, Lifton RP, Kahle KT, Kruszka P
IS21 family transposase cleaved donor complex traps two right-handed superhelical crossings.
1. Nat Commun - published April 2, 2023
2. Spínola-Amilibia M, Araújo-Bazán L, de la Gándara Á, Berger JM, Arias-Palomo E
Development and characterization of selective FAK inhibitors and PROTACs with in vivo activity.
1. Chembiochem - published April 2, 2023
2. Koide E, Mohardt ML, Doctor ZM, Yang A, Hao M, Donovan KA, Kuismi CC, Nelson AJ, Abell K, Aguiar M, Che J, Stokes MP, Zhang T, Aguirre AJ, Fischer ES, Gray NS, Jiang B, Nabet B
Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia.
1. Cancer Discov - published April 2, 2023
2. Glytsou C, Chen X, Zacharioudakis E, Al-Santli W, Zhou H, Nadorp B, Lee S, Lasry A, Sun Z, Papaioannou D, Cammer M, Wang K, Zal T, Zal MA, Carter BZ, Ishizawa J, Tibes R, Tsirigos A, Andreeff M, Gavathiotis E, Aifantis I
Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signalling.
1. J Biol Chem - published April 2, 2023
2. Cowan R, Trokter M, Oleksy A, Fedorova M, Sawmynaden K, Worzfeld T, Offermanns S, Matthews D, Carr MD, Hall G
CD4 Effector TCR Avidity for Peptide on APC Determines the Level of Memory Generated.
1. J Immunol - published April 2, 2023
2. Jones MC, Castonguay C, Nanaware PP, Weaver GC, Stadinski B, Kugler-Umana OA, Huseby ES, Stern LJ, McKinstry KK, Strutt TM, Devarajan P, Swain SL
Microsecond Motion of the Bacterial Transporter EmrE in Lipid Bilayers.
1. J Am Chem Soc - published April 2, 2023
2. Shcherbakov AA, Brousseau M, Henzler-Wildman KA, Hong M
Distinct enzymatic strategies for de novo generation of disulfide bonds in membranes.
1. Crit Rev Biochem Mol Biol - published April 2, 2023
2. Li W
Combining Signal Peptidase and Lipoprotein Processing Inhibitors Overcomes Ayr Resistance in Staphylococcus aureus.
1. Antimicrob Agents Chemother - published April 2, 2023
2. Stone MC, Mychack A, Coe KA, Walker S
Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation.
1. Microbiol Spectr - published April 2, 2023
2. Razvi E, DiFrancesco BR, Wasney GA, Morrison ZA, Tam J, Auger A, Baker P, Alnabelseya N, Rich JD, Sivarajah P, Whitfield GB, Harrison JJ, Melnyk RA, Nitz M, Howell PL
Structures of Get3d reveal a distinct architecture associated with the emergence of photosynthesis.
1. J Biol Chem - published April 2, 2023
2. Barlow AN, Manu MS, Saladi SM, Tarr PT, Yadav Y, Thinn AMM, Zhu Y, Laganowsky AD, Clemons WM Jr, Ramasamy S
A Time-Resolved FRET Assay Identifies a Small Molecule that Inhibits the Essential Bacterial Cell Wall Polymerase FtsW.
1. Angew Chem Int Ed Engl - published April 2, 2023
2. Park Y, Taguchi A, Baidin V, Kahne D, Walker S
A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging.
1. Cell Rep - published April 2, 2023
2. Falkovich R, Danielson EW, Perez de Arce K, Wamhoff EC, Strother J, Lapteva AP, Sheng M, Cottrell JR, Bathe M
Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F.
1. Nat Commun - published April 2, 2023
2. Ivanchenko MV, Hathaway DM, Klein AJ, Pan B, Strelkova O, De-la-Torre P, Wu X, Peters CW, Mulhall EM, Booth KT, Goldstein C, Brower J, Sotomayor M, Indzhykulian AA, Corey DP
Cryptochrome-Timeless structure reveals circadian clock timing mechanisms.
1. Nature - published April 2, 2023
2. Lin C, Feng S, DeOliveira CC, Crane BR
Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization.
1. J Virol - published April 2, 2023
2. Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
A potential histone-chaperone activity for the MIER1 histone deacetylase complex.
1. Nucleic Acids Res - published April 2, 2023
2. Wang S, Fairall L, Pham TK, Ragan TJ, Vashi D, Collins MO, Dominguez C, Schwabe JWR
Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals.
1. Cell Metab - published April 2, 2023
2. Kenny TC, Khan A, Son Y, Yue L, Heissel S, Sharma A, Pasolli HA, Liu Y, Gamazon ER, Alwaseem H, Hite RK, Birsoy K
Viral sponges sequester nucleotide signals to inactivate immunity.
1. Trends Microbiol - published April 2, 2023
2. Richmond-Buccola D, Kranzusch PJ
Bacterial spore germination receptors are nutrient-gated ion channels.
1. Science - published April 2, 2023
2. Gao Y, Amon JD, Artzi L, Ramírez-Guadiana FH, Brock KP, Cofsky JC, Marks DS, Kruse AC, Rudner DZ
Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1.
1. Nat Struct Mol Biol - published April 2, 2023
2. Woike S, Eustermann S, Jung J, Wenzl SJ, Hagemann G, Bartho J, Lammens K, Butryn A, Herzog F, Hopfner KP
Role of Histamine and Related Signaling in Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis.
1. Viruses - published April 2, 2023
2. Chen J, Song J, Plaisance-Bonstaff K, Mu S, Post SR, Dai L, Qin Z
Prediction of cooperative homeodomain DNA binding sites from high-throughput-SELEX data.
1. Nucleic Acids Res - published April 2, 2023
2. Cain B, Webb J, Yuan Z, Cheung D, Lim HW, Kovall RA, Weirauch MT, Gebelein B
Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis.
1. Sci Immunol - published April 2, 2023
2. Kong Q, Xia S, Pan X, Ye K, Li Z, Li H, Tang X, Sahni N, Yi SS, Liu X, Wu H, Elowitz MB, Lieberman J, Zhang Z
Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
1. Mol Cell - published April 2, 2023
2. Delbeau M, Omollo EO, Froom R, Koh S, Mooney RA, Lilic M, Brewer JJ, Rock J, Darst SA, Campbell EA, Landick R
CAND1 orchestrates CRLs through rock and roll.
1. Cell - published April 2, 2023
2. Xie Y, Zhao M
Caf1 regulates the histone methyltransferase activity of Ash1 by sensing unmodified histone H3.
1. Epigenetics Chromatin - published April 2, 2023
2. Yoon E, Song JJ
Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling.
1. Nat Commun - published April 2, 2023
2. Jones DTD, Dates AN, Rawson SD, Burruss MM, Lipper CH, Blacklow SC
A comprehensive map of hotspots of de novo telomere addition in Saccharomyces cerevisiae.
1. Genetics - published April 2, 2023
2. Ngo K, Gittens TH, Gonzalez DI, Hatmaker EA, Plotkin S, Engle M, Friedman GA, Goldin M, Hoerr RE, Eichman BF, Rokas A, Benton ML, Friedman KL
Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space.
1. Cell Death Discov - published April 2, 2023
2. Yu TG, Cha JS, Kim G, Sohn YK, Yoo Y, Kim U, Song JJ, Cho HS, Kim HS
Computational modeling and prediction of deletion mutants.
1. Structure - published April 2, 2023
2. Woods H, Schiano DL, Aguirre JI, Ledwitch KV, McDonald EF, Voehler M, Meiler J, Schoeder CT
An evolving view of Complex II - non-canonical complexes, megacomplexes, respiration, signaling, and beyond.
1. J Biol Chem - published April 2, 2023
2. Iverson TM, Singh PK, Cecchini G
Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY.
1. Cell Rep - published April 2, 2023
2. Prichard A, Lee J, Laughlin TG, Lee A, Thomas KP, Sy AE, Spencer T, Asavavimol A, Cafferata A, Cameron M, Chiu N, Davydov D, Desai I, Diaz G, Guereca M, Hearst K, Huang L, Jacobs E, Johnson A, Kahn S, Koch R, Martinez A, Norquist M, Pau T, Prasad G, Saam K, Sandhu M, Sarabia AJ, Schumaker S, Sonin A, Uyeno A, Zhao A, Corbett KD, Pogliano K, Meyer J, Grose JH, Villa E, Dutton R, Pogliano J
Synthesis and Characterization of (15)N(5)-Labeled Aflatoxin B(1)-Formamidopyrimidines and Aflatoxin B(1)-N7-Guanine from a Partial Double-Stranded Oligodeoxynucleotide as Internal Standards for Mass Spectrometric Measurements.
1. ACS Omega - published April 2, 2023
2. Jaruga P, Tomar R, Kant M, Vartanian V, Sexton B, Rizzo CJ, Turesky RJ, Stone MP, Lloyd RS, Dizdaroglu M
Direct Selection of DNA-Encoded Libraries for Biased Agonists of GPCRs on Live Cells.
1. JACS Au - published April 2, 2023
2. Cai B, El Daibani A, Bai Y, Che T, Krusemark CJ
Ribosome-targeting antibiotics and resistance via ribosomal RNA methylation.
1. RSC Med Chem - published April 2, 2023
2. Jeremia L, Deprez BE, Dey D, Conn GL, Wuest WM
Oridonin inhibits SARS-CoV-2 replication by targeting viral proteinase and polymerase.
1. Virol Sin - published April 2, 2023
2. Zhang Z, Zhang H, Zhang Y, Zhang Q, Liu Q, Hu Y, Chen X, Wang J, Shi Y, Deng C, Gong P, Zhang B, Li X, Zhu B, Ye H
Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary.
1. AIDS Res Hum Retroviruses - published April 2, 2023
2. Sanders-Beer BE, Archin NM, Brumme ZL, Busch M, Deleage C, O'Doherty U, Hughes SH, Jerome K, Jones RB, Karn J, Kearney MF, Keele B, Kulpa D, Laird G, Li JZ, Lichterfeld M, Nussenzweig MC, Persaud D, Yukl S, Siliciano RF, Mellors JW
Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.
1. Cell - published April 2, 2023
2. Singh I, Seth A, Billesbølle CB, Braz J, Rodriguiz RM, Roy K, Bekele B, Craik V, Huang XP, Boytsov D, Pogorelov VM, Lak P, O'Donnell H, Sandtner W, Irwin JJ, Roth BL, Basbaum AI, Wetsel WC, Manglik A, Shoichet BK, Rudnick G
Massively parallel base editing to map variant effects in human hematopoiesis.
1. Cell - published April 2, 2023
2. Martin-Rufino JD, Castano N, Pang M, Grody EI, Joubran S, Caulier A, Wahlster L, Li T, Qiu X, Riera-Escandell AM, Newby GA, Al'Khafaji A, Chaudhary S, Black S, Weng C, Munson G, Liu DR, Wlodarski MW, Sims K, Oakley JH, Fasano RM, Xavier RJ, Lander ES, Klein DE, Sankaran VG
Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.
1. Cell - published April 2, 2023
2. Hoi DM, Junker S, Junk L, Schwechel K, Fischel K, Podlesainski D, Hawkins PME, van Geelen L, Kaschani F, Leodolter J, Morreale FE, Kleine S, Guha S, Rumpel K, Schmiedel VM, Weinstabl H, Meinhart A, Payne RJ, Kaiser M, Hartl M, Boehmelt G, Kazmaier U, Kalscheuer R, Clausen T
BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses.
1. Curr Biol - published April 2, 2023
2. Houston J, Ohta M, Gómez-Cavazos JS, Deep A, Corbett KD, Oegema K, Lara-Gonzalez P, Kim T, Desai A
ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines.
1. Cell - published April 2, 2023
2. Hoffmann MAG, Yang Z, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Nakatomi LM, Storm KN, Moon WJ, Lin PJC, West AP Jr, Bjorkman PJ
Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2.
1. Elife - published April 2, 2023
2. Nocka LM, Eisen TJ, Iavarone AT, Groves JT, Kuriyan J
Directed Evolution of Seneca Valley Virus in Tumorsphere and Monolayer Cell Cultures of a Small-Cell Lung Cancer Model.
1. Cancers (Basel) - published April 2, 2023
2. Waqqar S, Lee K, Lawley B, Bilton T, Quiñones-Mateu ME, Bostina M, Burga LN
Improving the Modeling of Extracellular Ligand Binding Pockets in RosettaGPCR for Conformational Selection.
1. Int J Mol Sci - published April 2, 2023
2. Liessmann F, Künze G, Meiler J
Structural modeling of cytochrome P450 51 from a deep-sea fish points to a novel structural feature in other CYP51s.
1. J Inorg Biochem - published April 2, 2023
2. Goldstone JV, Lamb DC, Kelly SL, Lepesheva GI, Stegeman JJ
Ebolavirus Species-Specific Interferon Antagonism Mediated by VP24.
1. Viruses - published April 2, 2023
2. Ramanathan P, Tigabu B, Santos RI, Ilinykh PA, Kuzmina N, Vogel OA, Thakur N, Ahmed H, Wu C, Amarasinghe GK, Basler CF, Bukreyev A
Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing.
1. Life Sci Alliance - published April 1, 2023
2. Breidenstein A, Ter Beek J, Berntsson RP
Consensus-Based Evaluation of Outcome Measures in Pediatric Stroke Care: A Toolkit.
1. Pediatr Neurol - published April 1, 2023
2. Feldman SJ, Beslow LA, Felling RJ, Malone LA, Waak M, Fraser S, Bakeer N, Lee JEM, Sherman V, Howard MM, Cavanaugh BA, Westmacott R, Jordan LC
Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281.
1. J Biol Chem - published April 1, 2023
2. Liu J, Offei SD, Yoshimoto FK, Scott EE
COVID-19 and employee job performance trajectories: The moderating effect of different sources of status.
1. J Vocat Behav - published April 1, 2023
2. Liu X, Zheng X, Lee BY, Yu Y, Zhang M
Fetal Hemoglobin Regulation in Beta-Thalassemia.
1. Hematol Oncol Clin North Am - published April 1, 2023
2. Lu HY, Orkin SH, Sankaran VG
The tubulin structure, a quarter of a century later.
1. Mol Biol Cell - published April 1, 2023
2. Nogales E
Depicting protein structures as schematics.
1. Trends Biochem Sci - published April 1, 2023
2. Markert J, Luger K, Lee H, Hu H, Taylor NMI, Fernandez-Martinez J, Rout M, Alder N
Deciphering the evolution of flavin-dependent monooxygenase stereoselectivity using ancestral sequence reconstruction.
1. Proc Natl Acad Sci U S A - published April 1, 2023
2. Chiang CH, Wymore T, Rodríguez Benítez A, Hussain A, Smith JL, Brooks CL 3rd, Narayan ARH
A co-transcriptional ribosome assembly checkpoint controls nascent large ribosomal subunit maturation.
1. Nat Struct Mol Biol - published April 1, 2023
2. Sanghai ZA, Piwowarczyk R, Broeck AV, Klinge S
Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions.
1. J Med Chem - published April 1, 2023
2. Gao Y, Jiang B, Kim H, Berberich MJ, Che J, Donovan KA, Hatcher JM, Huerta F, Kwiatkowski NP, Liu Y, Liuni PP, Metivier RJ, Murali VK, Nowak RP, Zhang T, Fischer ES, Gray NS, Jones LH
Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome.
1. Nat Microbiol - published April 1, 2023
2. Russell SK, Harrison JK, Olson BS, Lee HJ, O'Brien VP, Xing X, Livny J, Yu L, Roberson EDO, Bomjan R, Fan C, Sha M, Estfanous S, Amer AO, Colonna M, Stappenbeck TS, Wang T, Hannan TJ, Hultgren SJ
Regulating GSDMB pore formation: to ignite or inhibit?
1. Cell Death Differ - published April 1, 2023
2. Ruan J
Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding.
1. Proc Natl Acad Sci U S A - published April 1, 2023
2. Stacey JCV, Tan A, Lu JM, James LC, Dick RA, Briggs JAG
High-resolution structures with bound Mn(2+) and Cd(2+) map the metal import pathway in an Nramp transporter.
1. Elife - published April 1, 2023
2. Ray S, Berry SP, Wilson EA, Zhang CH, Shekhar M, Singharoy A, Gaudet R
Evaluation of Nonmodified Wireframe DNA Origami for Acute Toxicity and Biodistribution in Mice.
1. ACS Appl Bio Mater - published April 1, 2023
2. Wamhoff EC, Knappe GA, Burds AA, Du RR, Neun BW, Difilippantonio S, Sanders C, Edmondson EF, Matta JL, Dobrovolskaia MA, Bathe M
Sensory specializations drive octopus and squid behaviour.
1. Nature - published April 1, 2023
2. Kang G, Allard CAH, Valencia-Montoya WA, van Giesen L, Kim JJ, Kilian PB, Bai X, Bellono NW, Hibbs RE
Structural basis of sensory receptor evolution in octopus.
1. Nature - published April 1, 2023
2. Allard CAH, Kang G, Kim JJ, Valencia-Montoya WA, Hibbs RE, Bellono NW
A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi.
1. Nat Commun - published April 1, 2023
2. Dos Reis TF, de Castro PA, Bastos RW, Pinzan CF, Souza PFN, Ackloo S, Hossain MA, Drewry DH, Alkhazraji S, Ibrahim AS, Jo H, Lightfoot JD, Adams EM, Fuller KK, deGrado WF, Goldman GH
Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast cancer.
1. Nat Commun - published April 1, 2023
2. Palakurthi B, Fross SR, Guldner IH, Aleksandrovic E, Liu X, Martino AK, Wang Q, Neff RA, Golomb SM, Lewis C, Peng Y, Howe EN, Zhang S
A Hitchhiker's Guide to Supplying Enzymatic Reducing Power into Synthetic Cells.
1. ACS Synth Biol - published April 1, 2023
2. Partipilo M, Claassens NJ, Slotboom DJ
The conserved AAA ATPase PCH-2 distributes its regulation of meiotic prophase events through multiple meiotic HORMADs in C. elegans.
1. PLoS Genet - published April 1, 2023
2. Russo AE, Giacopazzi S, Deshong A, Menon M, Ortiz V, Ego KM, Corbett KD, Bhalla N
SynDLP is a dynamin-like protein of Synechocystis sp. PCC 6803 with eukaryotic features.
1. Nat Commun - published April 1, 2023
2. Gewehr L, Junglas B, Jilly R, Franz J, Zhu WE, Weidner T, Bonn M, Sachse C, Schneider D
Does AlphaFold2 model proteins' intracellular conformations? An experimental test using cross-linking mass spectrometry of endogenous ciliary proteins.
1. Commun Biol - published April 1, 2023
2. McCafferty CL, Pennington EL, Papoulas O, Taylor DW, Marcotte EM
Organizing the synaptic junctions.
1. J Biol Chem - published April 1, 2023
2. Zhou Q
Fast conformational clustering of extensive molecular dynamics simulation data.
1. J Chem Phys - published April 1, 2023
2. Hunkler S, Diederichs K, Kukharenko O, Peter C
Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases.
1. Commun Biol - published April 1, 2023
2. Kumar H, Williford EE, Blake KS, Virgin-Downey B, Dantas G, Wencewicz TA, Tolia NH
Hsp90 provides a platform for kinase dephosphorylation by PP5.
1. Nat Commun - published April 1, 2023
2. Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA
Structures of human primosome elongation complexes.
1. Nat Struct Mol Biol - published April 1, 2023
2. He Q, Baranovskiy AG, Morstadt LM, Lisova AE, Babayeva ND, Lusk BL, Lim CJ, Tahirov TH
Surface ID: A Geometry-aware System for Protein Molecular Surface Comparison.
1. Bioinformatics - published April 1, 2023
2. Riahi S, Lee JH, Sorenson T, Wei S, Jager S, Olfati-Saber R, Park A, Wendt M, Minoux H, Qiu Y
RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis.
1. EMBO Mol Med - published April 1, 2023
2. Wong S, Tan YX, Loh AYT, Tan KY, Lee H, Aziz Z, Nelson SF, Özkan E, Kayserili H, Escande-Beillard N, Reversade B
Glutamylation is a negative regulator of microtubule growth.
1. Mol Biol Cell - published April 1, 2023
2. Chen J, Roll-Mecak A
Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS.
1. Elife - published April 1, 2023
2. Parameswaran J, Zhang N, Braems E, Tilahun K, Pant DC, Yin K, Asress S, Heeren K, Banerjee A, Davis E, Schwartz SL, Conn GL, Bassell GJ, Van Den Bosch L, Jiang J
An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans.
1. Sci Transl Med - published April 1, 2023
2. Andrews SF, Cominsky LY, Shimberg GD, Gillespie RA, Gorman J, Raab JE, Brand J, Creanga A, Gajjala SR, Narpala S, Cheung CSF, Harris DR, Zhou T, Gordon I, Holman L, Mendoza F, Houser KV, Chen GL, Mascola JR, Graham BS, Kwong PD, Widge A, Dropulic LK, Ledgerwood JE, Kanekiyo M, McDermott AB
Structural and functional properties of a plant NRAMP-related aluminum transporter.
1. Elife - published April 1, 2023
2. Ramanadane K, Liziczai M, Markovic D, Straub MS, Rosalen GT, Udovcic A, Dutzler R, Manatschal C
Profiling the Binding Activities of Peptides and Inhibitors to the U2 Auxiliary Factor Homology Motif (UHM) Domains.
1. ACS Med Chem Lett - published April 1, 2023
2. Yuan X, Howie KL, Kazemi Sabzvar M, Chinnaswamy K, Stuckey JA, Yang CY
Role of surfactants in electron cryo-microscopy film preparation.
1. Biophys J - published April 1, 2023
2. Michon B, López-Sánchez U, Degrouard J, Nury H, Leforestier A, Rio E, Salonen A, Zoonens M
Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1-EEF1A1 Axis.
1. Adv Sci (Weinh) - published April 1, 2023
2. Li M, Yang L, Chan AKN, Pokharel SP, Liu Q, Mattson N, Xu X, Chang WH, Miyashita K, Singh P, Zhang L, Li M, Wu J, Wang J, Chen B, Chan LN, Lee J, Zhang XH, Rosen ST, Müschen M, Qi J, Chen J, Hiom K, Bishop AJR, Chen CW
Appropriateness of the 30-day expected mortality metric in palliative radiation treatment: a narrative review.
1. Ann Palliat Med - published April 1, 2023
2. Navarro-Domenech I, Behroozian T, Hoskin P, Johnstone C, Recht A, Menten J, Oldenburger E, van der Linden YM, van der Velden JM, Nguyen QN, Simone CB 2nd, Johnstone P, Lutz S, Milton L, Andratschke N, Willmann J, Kazmierska J, Spałek M, Marta GN, Chow E, Raman S
Mapping N- to C-terminal Allosteric Coupling through Disruption of a Putative CD74 Activation Site in D-dopachrome Tautomerase.
1. J Biol Chem - published April 1, 2023
2. Chen E, Widjaja V, Kyro G, Allen B, Das P, Prahaladan VM, Bhandari V, Lolis EJ, Batista VS, Lisi GP
Vaccines Alone Cannot Slow the Evolution of SARS-CoV-2.
1. Vaccines (Basel) - published April 1, 2023
2. Van Egeren D, Stoddard M, White LF, Hochberg NS, Rogers MS, Zetter B, Joseph-McCarthy D, Chakravarty A
PK1 from Drosophila obscurin is an inactive pseudokinase with scaffolding properties.
1. Open Biol - published April 1, 2023
2. Zacharchenko T, Dorendorf T, Locker N, Van Dijk E, Katzemich A, Diederichs K, Bullard B, Mayans O