Member Publications

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141 Member Publications for November 2022

2022 Canadian Surgery Forum Sept. 15-17, 2022: Abstracts presented at the 2022 Canadian Surgery Forum in Toronto, Ontario.
1. Can J Surg - published November 30, 2022
2. Selim Y, Di Lena É, Safa N, Rahman S, Kaneva P, Feldman L, Abu-Omar N, Baig Z, Ginther N, Gill D, Baig Z, Sarwar Z, Verdiales C, Moser M, Verhoeff K, Mocanu V, Fang B, Dang J, Sun W, Switzer N, Birch D, Karmali S, La J, Alqaydi A, Wei X, Digby G, Brogly S, Merchant S, Purich K, Verhoeff K, Miles A, Kung JY, Shapiro AMJ, Bigam DL, Albacete S, Matkin A, Dumestre D, Peiris L, Valji R, Turner S, Purich K, Verhoeff K, Mador B, McLennan S, Safar A, Jastaniah A, Schellenberg M, Owattanapanich N, Grigorian A, Lam L, Nahmias J, Inaba K, Schellenberg M, Liasidis P, Inaba K, Demetriades D, Schellenberg M, Benjamin ER, Cowan S, Owattanapanich N, Wong MD, Inaba K, Demetriades D, Schellenberg M, Owattanapanich N, Emigh B, Karavites L, Clark DH, Lam L, Inaba K, Schellenberg M, Benjamin ER, Owattanapanich N, Inaba K, Demetriades D, Schellenberg M, Anderson GA, Owattanapanich N, Cheng V, Lam L, Inaba K, Myers L, Daza J, Cuthbertson B, Myles P, Shulman M, Wijeysundera D, Glass LT, Murphy PB, Allen L, Minkhorst K, Bowker D, Tang ES, Leslie K, Hawel JE, Verhoeff K, Ma O, Purich K, Skinner S, Dhaliwal R, Strickland M, Johnson G, Park J, Vergis A, Gillman L, Rivard J, Guidolin K, Lin J, Zorigtbaatar A, Nadeem M, Ibrahim T, Neilson Z, Kim KYP, Rajendran L, Chadi S, Quereshy F, Glass LT, Davidson M, Friedrich E, Champion C, Balvardi S, Semsar-Kazerooni K, Kaneva P, Mueller C, Vassiliou M, Al Mahroos M, Fiore J Jr, Schwartzman K, Feldman L, Gawad N, Purich K, Verhoeff K, Anderson B, McKechnie T, Daniel R, Kruse C, Levin M, Lee Y, Doumouras A, Hong D, Eskicioglu C, McKechnie T, Povolo C, Lee J, Lee Y, Park L, Doumouras A, Hong D, Bhandari M, Eskicioglu C, Purich K, Lee E, Verhoeff K, Sydora D, Turner S, Strickland M, Henley J, Boone D, Roberts S, Imbert E, McGrouther D, Manuel P, Li C, Dykstra M, Wang H, Snelgrove R, Skinner S, Verhoeff K, Purich K, Perry T, Strickland M, Dhaliwal R, Lenet T, Skanes S, Tropiano J, McIsaac D, Tinmouth A, Hallet J, Nicholls S, Fergusson D, Martel G, Lenet T, Tropiano J, Skanes S, Ivankovic V, McIsaac D, Tinmouth A, Patey A, Fergusson D, Martel G, Metz J, Naqvi R, Noppens R, Hawel J, Elnahas A, Schlachta C, Alkhamesi N, Ahn HS, Lenet T, Gilbert R, Mallick R, Shaw J, McIsaac D, Martel G, Do U, Pook M, Najafi T, Rajabiyazdi F, El-Kefraoui C, Balvardi S, Barone N, Elhaj H, Nguyen-Powanda P, Lee L, Baldini G, Feldman L, Fiore J Jr, Rouhi A, Purich K, Jogiat U, Mapiour D, Kim M, Greenberg B, Nadler A, Muaddi H, Stukel T, De Mestral C, Nathens A, Pautler S, Shayegan B, Hanna W, Schlachta C, Breau R, Hopkins L, Jackson T, Karanicolas P, Park L, Griffiths C, Ali S, Archer V, Cloutier Z, Choi D, McKechnie T, Serrano P, Vogt K, McClure JA, Jones P, Mrkobrada M, Flier S, Welk B, Dubois L, Bradley N, Khwaja K, Allen L, Tung L, Hameed M, Spoyalo K, Lampron J, Garcia-Ochoa C, Jastaniah A, Engels P, Talwar G, Cloutier Z, Minor S, Moffat B, Parry N, Vogt K, Deng SX, Ebeye T, Sharma BT, Samman A, Zulfiqar A, Purzner RH, Greene B, Tsang M, Jayaraman S, Murphy P, Allen L, Ball CG, Hameed M, Engels P, Nenshi R, Widder S, Minor S, Parry N, Bradley N, Moffat B, Vogt K, Alhabboubi M, Liberman S, Wong E, Chughtai T, Turner J, Lie J, Wiseman S, Li J, Mak N, Laplante S, Namazi B, Kiani P, Hashimoto D, Alseidi A, Pasten M, Brunt LM, Gill S, Davis B, Bloom M, Pernar L, Okrainec A, Madani A, Lie J, Hamilton T, Nabata K, Zhang JW, Zhao D, Dawe P, Hameed M, Drung J, Allen L, Leslie K, Drung J, Nixon T, Purich K, Verhoeff K, Skinner S, Dhaliwal R, Strickland M, Allard-Coutu A, Heller B, Wright V, Cho W, Wong M, Singh K, Mansouri S, Comeau É, Collin Y, Oviedo SC, Lee A, Rajendran L, Lamb T, Reid M, Turner A, Bertens K, Rekman J, Balaa F, Tweedy J, Neumann K, Porter G, D'Elia MA, Teo I, Forse CL, Musselman R, Hopkins B, Grozman L, Alshawan N, Fraser S, Bergman S, Pelletier JS, Vanounou T, Wong EG, Srivastava A, Nolan B, Qiao L, Jung J, Alibhai K, Raîche I, McDonald H, Gawad N, Lee C, Cheifetz R, Hawley P, Moon JJ, Rehany Z, Bakhshi M, Razek T, Grushka J, Boulanger N, Watt L, Vivier A, Clark G, Fata P, Deckelbaum D, Khwaja K, Jastaniah A, Wong E, How N, Ren K, Qiu Y, Hamann K, Spoyalo K, Lalande A, MacNeill A, Park J, Lalande A, Alexis S, Spoyalo K, Patterson K, Gadhari N, Zhao J, MacNeill A, Baig Z, Ahmed R, Farooq A, Karimuddin A, Schweitzer C, Wiseman S, Keogh J, Chhor A, Begum H, Akhtar-Danesh N, Finley C, Huo B, Manos D, Xu Z, Matheson K, Chun S, Fris J, Wallace A, French D, Patel YS, Baste JM, Shargall Y, Waddell TK, Yasufuku K, Machuca TN, Xie F, Thabane L, Hanna WC, Patel YS, Beauchamp MK, Wald J, Mbuagbaw L, Key BL, Green SM, Hanna WC, Jogiat U, Behzadi A, Donahoe L, Nasralla A, Poon J, Safieddine N, Seyednejad N, Tavakoli I, Turner S, McGuire AL, Sharma S, Hilzenrat RA, McConechy M, Frank I, Hughsman C, Yip S, Choi JJ, Yee J, Jogiat U, Sasewich H, Turner S, Baracos V, Eurich D, Filafilo H, Bedard E, Lee Y, Samarasinghe Y, Patel J, Khondker A, McKechnie T, Samarasinghe N, Finley C, Hanna W, Shargall Y, Agzarian J, Barber E, Whidden M, Aguirre F, Graham A, Akhtar-Danesh GG, Chhor A, Begum H, Ewusie J, Mbuagbaw L, Yaron S, Bondzi-Simpson A, Keshishi M, Ademe Y, Tizazu A, Rose M, Uddin S, Ko M, Bowker R, Ddamba J, French D, Wallace A, Ahmadi N, Safieddine N, Gazala S, Simone C, Abdul SA, Wright F, Finley C, Villeneuve PJ, Gilbert S, Sundaresan S, Seely AJE, Maziak DE, Patel P, Manos D, Wallace A, Plourde M, Harrison L, Turner D, Ringash J, Manuel D, Kidane B, Gupta V, Decker K, Davis L, Darling G, Compton C, Coburn N, Boyes R, Pugliese M, Mahar A, Hsu A, Shi G, Kokavec A, Ho E, Waterman R, Wang E, Harnden K, Malthaner R, Nayak R, Qiabi M, Shi G, Malthaner R, Nayak R, Qiabi M, Alaichi JA, Patel Y, Farrokhyar F, Simunovic M, Hanna WC, Kidane B, Gowing S, Liu R, Srinathan S, Tan L, Qu LC, Malthaner R, Alaichi J, Malik P, Patel Y, Hanna W, Mackay E, Fahim U, Hafizi A, Ashrafi AS, Lee J, McKechnie T, Amin N, Doumouras A, Hong D, Eskicioglu C, Purich K, Streu C, Wong C, Schiller D, Castelo M, Sue-Chue-Lam C, Paszat L, Scheer A, Hansen B, Kishibe T, Baxter N, Caycedo-Marulanda A, Neary E, Ibrahim T, Verschoor C, Patel S, Merchant S, Chadi S, Romagnolo L, Caycedo-Marulanda A, Verschoor C, Brown C, Karimuddin A, Raval M, Phang T, Vikis E, Melich G, Patel S, Brennan K, Patel S, Caycedo-Marulanda A, Merchant S, Booth C, Kong W, McClintock C, Bankhead C, Heneghan C, Brennan K, Patel S, McClintock C, Merchant S, Caycedo-Marulanda A, Booth C, Bankhead C, Heneghan C, Brennan K, Zhang L, Flemming J, Djerboua M, Nanji S, Caycedo-Marulanda A, Merchant S, Patel S, Garfinkle R, Demian M, Sabboobeh S, Moon J, Hulme-Moir M, Liberman AS, Feinberg S, Hayden DM, Chadi SA, Demyttenaere S, Samuel L, Hotakorzian N, Quintin L, Morin N, Ghitulescu G, Faria J, Vasilevsky CA, Boutros M, Sharma S, Mckechnie T, Khamar J, Ichhpuniani S, Eskicioglu C, Candy S, Patel S, Merchant S, Caycedo-Marulanda A, Bankhead C, Heneghan C, McKechnie T, Govind S, Lee J, Lee Y, Hong D, Eskicioglu C, McKechnie T, Lu J, Khamar J, Lee Y, Amin N, Hong D, Eskicioglu C, McKechnie T, Cardenas L, Schep D, Doumouras A, Hong D, Wong R, Levine O, Eskicioglu C, Lee L, Mueller C, Stein B, Charlebois P, Liberman S, Fried G, Feldman L, Robitaille S, Wang A, Liberman S, Charlebois P, Stein B, Fiore JF Jr, Feldman L, Lee L, Robitaille S, Wang A, Liberman S, Charlebois P, Stein B, Fiore JF Jr, Feldman L, Lee L, Sadri H, Barkun A, Selznick S, Levy J, Bogdan R, Hawel J, Elnahas A, Alkhamesi NA, Schlachta CM, Wiseman V, Caycedo-Marulanda A, Iaboni N, Hurlbut D, Kaufmann M, Ren KYM, Jamzad A, Mousavi P, Fichtinger G, Nicol CJB, Rudan JF, Wiseman V, Brennan K, Caycedo-Marulanda A, Merchant S, McClintock C, Patel SV, Wiseman V, McClintock C, Bankhead C, Merchant S, Caycedo-Marulanda A, Booth C, Heneghan C, Brennan K, Zhang L, Huo B, Donaldson A, Flemming J, Nanji S, Caycedo-Marulanda A, Merchant S, Brogly S, Patel S, Baker L, Lenet T, Park L, Murthy S, Musselman R, Ichhpuniani S, McKechnie T, Lee J, Biro J, Lee Y, Park L, Doumouras A, Hong D, Eskicioglu C, Johnson G, Singh H, Helewa R, Reynolds K, Sibley K, Doupe M, Zhang L, Brennan K, Flemming J, Nanji S, Merchant S, Djerboua M, Caycedo-Marulanda A, Patel S, Holden J, Johnson G, Hochman D, Helewa R, Moon JJ, Garfinkle R, Dell'Aniello S, Zelkowitz P, Vasilevsky CA, Brassard P, Boutros M, Moon JJ, Zoughlami A, Abibula W, Amar A, Ghitulescu G, Vasilevsky CA, Brassard P, Boutros M, Moon JJ, Araji T, Pang A, Vasilevsky CA, Boutros M, Moon JJ, Ehlebracht A, Faria J, Ghitulescu G, Morin N, Pang A, Vasilevsky CA, Boutros M, Paradis T, Robitaille S, Oliver M, Charlebois P, Stein B, Liberman S, Feldman LS, Lee L, Bayat Z, Kennedy E, Victor C, Govindarajan A, Patel S, Zhang L, Brennan K, Djerboua M, Nanji S, Merchant SJ, Caycedo-Marulanda A, Flemming J, Maalouf MF, Robitaille S, Penta R, Pook M, Fiore JF Jr, Feldman L, Lee L, Wachtel A, Wong-Chong N, Marinescu D, Bhatnagar S, Morin N, Ghitulescu G, Vasilevsky CA, Faria J, Boutros M, Baronas V, Arif A, Ladua G, Bhang E, Brown C, Donellan F, Stuart H, Loree J, Wiseman V, Patel S, Zhang L, MacDonald PH, Merchant S, Barnett KW, Caycedo-Marulanda A, Lie J, Brown C, Karimuddin A, Stuart H, Ghuman A, Phang T, Raval M, Yoon HM, Hajjar R, Fragoso G, Oliero M, Calvé A, Rendos HV, Gonzalez E, Brereton NJB, Cuisiniere T, Gerkins C, Djediai S, Annabi B, Diop K, Routy B, Laplante P, Cailhier JF, Taleb N, Alratrout H, Dagbert F, Loungnarath R, Sebajang H, Schwenter F, Wassef R, Ratelle R, Debroux E, Richard C, Santos MM, Ehlebracht A, Hamad D, Alsulaim H, Monton O, Marinescu D, Pang A, Vasilevsky CA, Boutros M, Caminsky N, Marinescu D, Alqahtani M, Pang A, Ghitulescu G, Vasilevsky CA, Boutros M, Caminsky N, Marinescu D, Garfinkle R, Boutros M, Gilbert R, Zwiep T, Greenberg J, Lenet T, Musselman R, Williams L, Raiche I, McIsaac D, Thavorn K, Fergusson D, Moloo H, Morin G, Charbonneau J, Paré X, Frigault J, Letarte F, Auer RC, Ott M, Karanicolas P, Brackstone M, Ashmalla S, Weaver J, Tagalakis V, Boutros M, Stotland P, Caycedo-Marulanda A, Moloo H, Jayaraman S, Patel S, LeGal G, Spadafora S, Maclellan S, Trottier D, Jonker D, Asmis T, Mallick R, Ramsay T, Carrier M, Phang T, Shojaei D, Motamedi A, Ghuman A, Karimuddin A, Raval M, Brown C, Shojaei D, Hopkins J, Wang H, Buie D, Hopkins J, Wang H, Buie D, Levin Y, Al Busaidi N, Rajabiyazdi F, Demian M, Boutros M, Alam A, Farooq A, Brown C, Phang T, Ghuman A, Karimuddin A, Raval M, Udwadia F, Caminsky N, Marinescu D, Alqahtani M, Pang A, Vasilevsky CA, Boutros M, Mansouri S, Oviedo SC, McFadden N, Lagace P, Spence R, Hirsch G, Neumann K, Lagace P, Neumann K, Spence R, El-Kefraoui C, Johnson G, Singh H, Helewa R, Mainprize M, Yilbas A, Netto FS, Katz J, Melland-Smith M, Sharma B, Khan U, Selzner M, Verhoeff K, Mocanu V, Dang J, Wilson H, Switzer N, Birch D, Karmali S, Verhoeff K, Mocanu V, Jogiat U, Forbes H, Switzer N, Birch D, Karmali S, Nasser K, Verhoeff K, Mocanu V, Kung J, Purich K, Switzer N, Birch D, Karmali S, Mailloux O, Tassé N, Tchernof A, Nadeau M, Dawe P, Beckett A, Biertho L, Purich K, Lin A, Verhoeff K, Mocanu V, Kung JY, Birch DW, Karmali S, Switzer NJ, Whyte M, Fowler-Woods M, Fowler-Woods A, Shingoose G, Hatala A, Daeninck F, Vergis A, Hardy K, Clouston K, Li T, Debru E, Ahmad MS, Sun W, Dang J, Switzer N, Birch D, Karmali S, De Gara C, Sun W, Halasz J, Dang J, Switzer N, Kanji A, Birch D, Modi R, Karmali S, Ahn HS, Gu J, Jarrar A, Kolozsvari N, Lee Y, Samarasinghe Y, Chen L, Hapugall A, Javidan A, McKechnie T, Doumouras A, Hong D, Roach E, Laplante S, Stogryn S, Maeda A, Jackson T, Okrainec A, Chow A, Birch D, Karmali S, Kanji A, Switzer N, Trac J, Balas M, Gee D, Hutter M, Meireles O, Jung J, He W, Vergis A, Hardy K, Ramji K, Boudreau V, Hong D, Anvari M, Iranmanesh P, Barlow K, Cookson T, Bolis R, Shanthanna H, Shiroky J, Kouzmina E, Deghan S, Zevin B, Koziak C, Cloutier Z, Cookson T, Barlow K, Boudreau V, Anvari M, Hossain I, Brodie J, O'Brien E, Tedman-Aucoin K, Lawlor D, Murphy R, Twells L, Pace D, Ellsmere J, Evans B, Mocanu V, Zhang T, Deehan E, Kao D, Hotte N, Birch D, Karmali S, Samarasinghe K, Walter J, Madsen K, Hanna N, Williams E, Kong W, Fundytus A, Booth C, Patel S, Caycedo-Marulanda A, Chung W, Nanji S, Merchant S, Castelo M, Hansen B, Paszat L, Baxter N, Scheer A, Pook M, Ghezeljeh TN, Lapointe-Gagner M, Nguyen-Powanda P, Elhaj H, Rajabiyazdi F, Lee L, Feldman LS, Fiore J Jr, Zuckerman J, Sutradhar R, Haas B, Guttman M, Eskander A, Coburn N, Chesney T, Tillman B, Zuk V, Mahar A, Hsu A, Chan W, Hallet J, Choi WJ, Guidolin K, Servidio-Italiano F, Quereshy F, Sapisochin G, Watanabe A, Prisman E, Mitmaker E, Walker R, Wu J, Nguyen A, Wiseman S, Saravana-Bawan B, Hong D, Gupta M, Pasternak J, Cyr D, Vergara-Fernandez O, Brar A, Conner J, Kirsch R, Brar M, Kennedy E, Govindarajan A, Gryfe R, MacRae H, Cohen Z, McLeod R, Swallow C, Brackstone M, Ghasemi F, Ivankovic V, Delisle M, Stacey D, Abou-Khalil J, Balaa F, Bertens K, Dingley B, Martel G, McAlpine K, Nessim C, Tadros S, Carrier M, Auer R, Nair AG, Lim D, Hirpara D, Eskander A, Coburn N, Sutradhar R, Chan W, Hallet J, Stockley C, Pickard F, Mathieson A, Hogan M, Seal M, Ng D, Acidi B, Johnston W, Callegaro D, Brar S, Gladdy R, Chung P, Catton C, Khalili K, Honore C, Swallow C, Luu S, Fu N, Kazazian K, Pacholczyk K, Ng D, Swett-Cosentino J, Savage P, Shibahara Y, Kalimuthu S, Espin-Garcia O, Conner J, Yeung J, Darling G, Swallow C, Meloche-Dumas L, Mercier F, Barabash V, Law C, Coburn N, Singh S, Myrehaug S, Chan W, Hallet J, D'Elia MA, Auer RC, Eom A, Muhn N, Heller B, Lovrics P, Tang K, Khan S, Ng D, Koerber D, Al-Sukhni E, Cyr D, Kazazian K, Swallow C, Schmitz E, Apte S, Nessim C, Chen KT, Ban J, Chen L, McKevitt E, Warburton R, Pao JS, Dingee C, Kuusk U, Bazzarelli A, Newman-Bremang J, Hong NL, Gagliardi A, Nyhof B, Verhoeff K, Marfil-Garza B, Sandha G, Cooper D, Dajani K, Bigam D, Anderson B, Kin T, Lam A, O'Gorman D, Senior P, Ricordi C, Shapiro AMJ, Jette N, Moser M, Mir Z, Lam H, Flemming J, Jalink D, Nanji S, Bennett S, Griffiths C, Zhang B, Tywonek K, Meyers B, Serrano P, Rajendran L, Lenet T, Shorr R, Abou-Khalil J, Bertens K, Balaa F, Martel G, Zuckerman J, Jayaraman S, Wei A, Mahar A, Kaliwal Y, Martel G, Coburn N, Hallet J, Choi WJ, Williams P, Claasen M, Ivanics T, Englesakis M, Gallinger S, Hansen B, Sapisochin G, Choi WJ, Ivanics T, Claasen M, Gallinger S, Hansen B, Sapisochin G, Gilbert R, Lenet T, Abou-Khalil J, Balaa F, Martel G, Brind'Amour A, Bertens K, Lenet T, Balaa F, Bertens K, Martel G, Abou-Khalil J, Amhis N, Collin Y, Claasen M, Ivanics T, Toso C, Adam R, Ijzermans J, Sapisochin G, Polak W, Mansouri S, Léveillé M, Lawson C, Collin Y, Tai LH, Workewych A, Greene B, Jayaraman S, Tsang M, Lee A, Al-Arnawoot A, Rajendran L, Lamb T, Turner A, Reid M, Rekman J, Mimeault R, Abou-Khalil J, Bertens K, Martel G, Balaa F, Waugh E, Zhang C, Lemke M, Glinka J, Leslie K, Skaro A, Tang E, Zhu A, Greene B, Tsang M, Jayaraman S, Nabavian H, Bubis L, Jayaraman S, Tsang ME, Roldan J, Ganescu O, Vanounou T, Pelletier JS, Lagrotteria A, Greene B, Tsang M, Jayaraman S, Roldan J, Ganescu O, Pelletier JS, Vanounou T, Rajendran L, Choi WJ, Muaddi H, Ivanics T, Classen MPAW, Sapisochin G, European Liver and Intestine Transplant Association
A Colorimetric Assay to Identify and Characterize Bacterial Primase Inhibitors.
1. Methods Mol Biol - published November 29, 2022
2. Pang AH, Tsodikov OV
COVID-19 and CKD: Employment, Food Security and Healthcare in El Salvador.
1. Ann Glob Health - published November 23, 2022
2. Leibler JH, Keogh SA, Jarquín E, Garcia-Trabanino R, Velázquez JJA, Pilarte DL, Beltran M, Delgado IS, Petropoulos ZE, Friedman DJ, Brooks DR, Scammell MK
Aβ and Tau Prions Causing Alzheimer's Disease.
1. Methods Mol Biol - published November 18, 2022
2. Condello C, Merz GE, Aoyagi A, DeGrado WF, Prusiner SB
Cross-reactive neutralizing human monoclonal antibodies mapping to variable antigenic sites on the norovirus major capsid protein.
1. Front Immunol - published November 17, 2022
2. Ford-Siltz LA, Tohma K, Alvarado GS, Kendra JA, Pilewski KA, Crowe JE Jr, Parra GI
Radical-SAM dependent nucleotide dehydratase (SAND), rectification of the names of an ancient iron-sulfur enzyme using NC-IUBMB recommendations.
1. Front Mol Biosci - published November 17, 2022
2. Ji Y, Wei L, Da A, Stark H, Hagedoorn PL, Ciofi-Baffoni S, Cowley SA, Louro RO, Todorovic S, Mroginski MA, Nicolet Y, Roessler MM, Le Brun NE, Piccioli M, James WS, Hagen WR, Ebrahimi KH
Identification of genes related to sexual differentiation and sterility in embryonic gonads of Mule ducks by transcriptome analysis.
1. Front Genet - published November 17, 2022
2. Yang Y, Li X, Ye S, Chen X, Wang L, Qian Y, Xin Q, Li L, Gong P
Spatial modeling of vaccine deserts as barriers to controlling SARS-CoV-2.
1. Commun Med (Lond) - published November 10, 2022
2. Rader B, Astley CM, Sewalk K, Delamater PL, Cordiano K, Wronski L, Rivera JM, Hallberg K, Pera MF, Cantor J, Whaley CM, Bravata DM, Lee L, Patel A, Brownstein JS
An atypical RNA quadruplex marks RNAs as vectors for gene silencing.
1. Nat Struct Mol Biol - published November 9, 2022
2. Roschdi S, Yan J, Nomura Y, Escobar CA, Petersen RJ, Bingman CA, Tonelli M, Vivek R, Montemayor EJ, Wickens M, Kennedy SG, Butcher SE
Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants.
1. Nat Commun - published November 9, 2022
2. Tian S, Xiong X, Zeng J, Wang S, Tremblay BJ, Chen P, Chen B, Liu M, Chen P, Sheng K, Zeve D, Qi W, Breault DT, Rodríguez C, Gerhard R, Jin R, Doxey AC, Dong M
CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site.
1. Nat Commun - published November 9, 2022
2. Gong L, Liu X, Jiao L, Yang X, Lemoff A, Liu X
IGF2BP2 promotes cancer progression by degrading the RNA transcript encoding a v-ATPase subunit.
1. Proc Natl Acad Sci U S A - published November 8, 2022
2. Latifkar A, Wang F, Mullmann JJ, Panizza E, Fernandez IR, Ling L, Miller AD, Fischbach C, Weiss RS, Lin H, Cerione RA, Antonyak MA
Europium-151 and iron-57 nuclear resonant vibrational spectroscopy of naturally abundant KEu(III)Fe(II)(CN)₆ and Eu(III)Fe(III)(CN)₆ complexes.
1. Dalton Trans - published November 8, 2022
2. Wang H, Huang SD, Yan L, Hu MY, Zhao J, Alp EE, Yoda Y, Petersen CM, Thompson MK
Solvent Deuterium Isotope Effects of Substrate Reduction by Nitrogenase from Azotobacter vinelandii.
1. J Am Chem Soc - published November 8, 2022
2. MacArdle SG, Rees DC
Investigation of the Enzymes Required for the Biosynthesis of 2,3-Diacetamido-2,3-dideoxy-d-glucuronic acid in Psychrobacter cryohalolentis K5^T.
1. Protein Sci - published November 8, 2022
2. Hofmeister DL, Seltzner CA, Bockhaus NJ, Thoden JB, Holden HM
Single Atom Ring Contraction of Peptide Macrocycles Using Cornforth Rearrangement.
1. Angew Chem Int Ed Engl - published November 8, 2022
2. Huh S, Saunders GJ, Yudin AK
Histone H3 proline 16 hydroxylation regulates mammalian gene expression.
1. Nat Genet - published November 8, 2022
2. Liu X, Wang J, Boyer JA, Gong W, Zhao S, Xie L, Wu Q, Zhang C, Jain K, Guo Y, Rodriguez J, Li M, Uryu H, Liao C, Hu L, Zhou J, Shi X, Tsai YH, Yan Q, Luo W, Chen X, Strahl BD, von Kriegsheim A, Zhang Q, Wang GG, Baldwin AS, Zhang Q
Pharmacological blockade of TEAD-YAP reveals its therapeutic limitation in cancer cells.
1. Nat Commun - published November 8, 2022
2. Sun Y, Hu L, Tao Z, Jarugumilli GK, Erb H, Singh A, Li Q, Cotton JL, Greninger P, Egan RK, Tony Ip Y, Benes CH, Che J, Mao J, Wu X
Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex.
1. Elife - published November 8, 2022
2. McCafferty CL, Papoulas O, Jordan MA, Hoogerbrugge G, Nichols C, Pigino G, Taylor DW, Wallingford JB, Marcotte EM
HIV-1 Vpu restricts Fc-mediated effector functions in vivo.
1. Cell Rep - published November 8, 2022
2. Prévost J, Anand SP, Rajashekar JK, Zhu L, Richard J, Goyette G, Medjahed H, Gendron-Lepage G, Chen HC, Chen Y, Horwitz JA, Grunst MW, Zolla-Pazner S, Haynes BF, Burton DR, Flavell RA, Kirchhoff F, Hahn BH, Smith AB 3rd, Pazgier M, Nussenzweig MC, Kumar P, Finzi A
Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics.
1. Cell - published November 8, 2022
2. Janetzko J, Kise R, Barsi-Rhyne B, Siepe DH, Heydenreich FM, Kawakami K, Masureel M, Maeda S, Garcia KC, von Zastrow M, Inoue A, Kobilka BK
Accurate Identification of Mucinous Pancreatic Cystic Lesions Using Small-Volume Analytes.
1. J Surg Res - published November 8, 2022
2. Caiazza F, Conroy PC, Ivry SL, York T, Lin J, Hernandez S, Hoffmann TJ, Francis SS, Park WG, Yip-Schneider MT, Schmidt CM, Brand R, Craik CS, Kirkwood K
Structure of the RhlR-PqsE complex from Pseudomonas aeruginosa reveals mechanistic insights into quorum-sensing gene regulation.
1. Structure - published November 8, 2022
2. Feathers JR, Richael EK, Simanek KA, Fromme JC, Paczkowski JE
DNA-stimulated liquid-liquid phase separation by eukaryotic topoisomerase II modulates catalytic function.
1. Elife - published November 7, 2022
2. Jeong J, Lee JH, Carcamo CC, Parker MW, Berger JM
Mithplatins: Mithramycin SA-Pt(II) Complex Conjugates for the Treatment of Platinum Resistant Ovarian Cancers.
1. ChemMedChem - published November 7, 2022
2. Bhosale SS, Mandal A, Hou C, McCorkle JR, Schweer D, Hill KS, Kolesar JM, Tsodikov OV, Rohr J, Subramanian V
The application of Tong-fu therapeutic method on ulcerative colitis: A systematic review and meta-analysis for efficacy and safety of rhubarb-based therapy.
1. Front Pharmacol - published November 7, 2022
2. Li Y, Ye Z, He H, Hu Y, Wu M, Li L, Chen L, Qian H, Shi Q, Zhang C, Yu H, Zhao Q, Liu X, Qin K, Ye Q
Profiling human pathogenic repeat expansion regions by synergistic and multi-level impacts on molecular connections.
1. Hum Genet - published November 7, 2022
2. Fan C, Chen K, Wang Y, Ball EV, Stenson PD, Mort M, Bacolla A, Kehrer-Sawatzki H, Tainer JA, Cooper DN, Zhao H
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks.
1. Nat Commun - published November 7, 2022
2. Kapoor-Vazirani P, Rath SK, Liu X, Shu Z, Bowen NE, Chen Y, Haji-Seyed-Javadi R, Daddacha W, Minten EV, Danelia D, Farchi D, Duong DM, Seyfried NT, Deng X, Ortlund EA, Kim B, Yu DS
Cryo-EM structures of prefusion SIV envelope trimer.
1. Nat Struct Mol Biol - published November 7, 2022
2. Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess JW Jr, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD
A structural biology community assessment of AlphaFold2 applications.
1. Nat Struct Mol Biol - published November 7, 2022
2. Akdel M, Pires DEV, Pardo EP, Jänes J, Zalevsky AO, Mészáros B, Bryant P, Good LL, Laskowski RA, Pozzati G, Shenoy A, Zhu W, Kundrotas P, Serra VR, Rodrigues CHM, Dunham AS, Burke D, Borkakoti N, Velankar S, Frost A, Basquin J, Lindorff-Larsen K, Bateman A, Kajava AV, Valencia A, Ovchinnikov S, Durairaj J, Ascher DB, Thornton JM, Davey NE, Stein A, Elofsson A, Croll TI, Beltrao P
Biological nitrogen fixation in theory, practice, and reality: A perspective on the molybdenum nitrogenase system.
1. FEBS Lett - published November 7, 2022
2. Threatt SD, Rees DC
Structure of the IscB-ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9.
1. Nat Commun - published November 7, 2022
2. Kato K, Okazaki S, Kannan S, Altae-Tran H, Esra Demircioglu F, Isayama Y, Ishikawa J, Fukuda M, Macrae RK, Nishizawa T, Makarova KS, Koonin EV, Zhang F, Nishimasu H
Combinatorial and antagonistic effects of tubulin glutamylation and glycylation on katanin microtubule severing.
1. Dev Cell - published November 7, 2022
2. Szczesna E, Zehr EA, Cummings SW, Szyk A, Mahalingan KK, Li Y, Roll-Mecak A
Structural Basis of Sequential and Concerted Cooperativity.
1. Biomolecules - published November 7, 2022
2. Morea V, Angelucci F, Tame JRH, Di Cera E, Bellelli A
Structural basis for the activation of the lipid scramblase TMEM16F.
1. Nat Commun - published November 5, 2022
2. Arndt M, Alvadia C, Straub MS, Clerico Mosina V, Paulino C, Dutzler R
A prospective, open-label, multicenter phase IV clinical trial on the safety and efficacy of lobaplatin-based chemotherapy in advanced breast cancer.
1. Ther Adv Med Oncol - published November 4, 2022
2. Yan M, Yuan P, Ouyang Q, Cheng Y, Han G, Wang D, Ran L, Sun T, Zhao D, Bai Y, Yang S, Wang X, Wu R, Zeng X, Yao H, Ji X, Jiang J, Hu X, Lin H, Zheng L, Zhu Z, Ge W, Yang J, Cui T, Zhang X, Lu F, Li W, Xu H, Kang M, Gong P, Zou L, Liu J, Zhang H, Yu H, Xu B
Designing Quality Assurance Process for Quality Control of NMR Metabolomics Studies of Human Blood.
1. NMR Biomed - published November 4, 2022
2. Ih M, M SG, Ab Z, J W, Mv F, P K, Bt H, Se A, Af F, Nd M, Ll C
The cardioprotective potentials and the involved mechanisms of phenolic acids in drug-induced cardiotoxicity.
1. Eur J Pharmacol - published November 4, 2022
2. Liu X, Tian R, Tao H, Wu J, Yang L, Zhang Y, Meng X
The SMC-family Wadjet complex protects bacteria from plasmid transformation by recognition and cleavage of closed-circular DNA.
1. Mol Cell - published November 3, 2022
2. Deep A, Gu Y, Gao YQ, Ego KM, Herzik MA Jr, Zhou H, Corbett KD
Topology of pain networks in patients with temporomandibular disorder and pain-free controls with and without concurrent experimental pain: A pilot study.
1. Front Pain Res (Lausanne) - published November 3, 2022
2. Smith JL, Allen JW, Fleischer CC, Harper DE
The His-tag as a decoy modulating preferred orientation in cryoEM.
1. Front Mol Biosci - published November 3, 2022
2. Bromberg R, Cai K, Guo Y, Plymire D, Emde T, Puzio M, Borek D, Otwinowski Z
Identification of genetic interactions with priB links the PriA/PriB DNA replication restart pathway to double-strand DNA break repair in Escherichia coli.
1. G3 (Bethesda) - published November 3, 2022
2. McKenzie AM, Henry C, Myers KS, Place MM, Keck JL
Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity.
1. Brain Pathol - published November 3, 2022
2. Reimann RR, Puzio M, Rosati A, Emmenegger M, Schneider BL, Valdés P, Huang D, Caflisch A, Aguzzi A
A microbial transporter of the dietary antioxidant ergothioneine.
1. Cell - published November 3, 2022
2. Dumitrescu DG, Gordon EM, Kovalyova Y, Seminara AB, Duncan-Lowey B, Forster ER, Zhou W, Booth CJ, Shen A, Kranzusch PJ, Hatzios SK
Membrane-mediated protein interactions drive membrane protein organization.
1. Nat Commun - published November 3, 2022
2. Jiang Y, Thienpont B, Sapuru V, Hite RK, Dittman JS, Sturgis JN, Scheuring S
Antibody Recognition of CD4-Induced Open HIV-1 Env Trimers.
1. J Virol - published November 3, 2022
2. Yang Z, Dam KA, Gershoni JM, Zolla-Pazner S, Bjorkman PJ
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions.
1. Infect Immun - published November 3, 2022
2. Castro-Córdova P, Otto-Medina M, Montes-Bravo N, Brito-Silva C, Lacy DB, Paredes-Sabja D
Strategies for change: thriving as a disabled individual in STEMM.
1. Pathog Dis - published November 3, 2022
2. Crabtree A, Neikirk K, Marshall A, Barongan T, Beasley HK, Lopez EG, Stephens D, Murray S, Spencer EC, Martinez D, Vang C, Jenkins F, Damo S, Vue Z
The Sia System and c-di-GMP Play a Crucial Role in Controlling Cell-Association of Psl in Planktonic P. aeruginosa.
1. J Bacteriol - published November 3, 2022
2. Dreifus JE, O'Neal L, Jacobs HM, Subramanian AS, Howell PL, Wozniak DJ, Parsek MR
Structure-based design of bitopic ligands for the µ-opioid receptor.
1. Nature - published November 3, 2022
2. Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S
Apolipoprotein L1 (APOL1) cation current in HEK-293 cells and in human podocytes.
1. Pflugers Arch - published November 3, 2022
2. Vandorpe DH, Heneghan JF, Waitzman JS, McCarthy GM, Blasio A, Magraner JM, Donovan OG, Schaller LB, Shah SS, Subramanian B, Riella CV, Friedman DJ, Pollak MR, Alper SL
Cinnamaldehyde causes developmental neurotoxicity in zebrafish via the oxidative stress pathway that is rescued by astaxanthin.
1. Food Funct - published November 3, 2022
2. Chang K, Zeng N, Ding Y, Zhao X, Gao C, Li Y, Wang H, Liu X, Niu Y, Sun Y, Li T, Shi Y, Wu C, Li Z
Human histone pre-mRNA assembles histone or canonical mRNA-processing complexes by overlapping 3'-end sequence elements.
1. Nucleic Acids Res - published November 3, 2022
2. Ielasi FS, Ternifi S, Fontaine E, Iuso D, Couté Y, Palencia A
Small-angle X-ray scattering studies of enzymes.
1. Curr Opin Chem Biol - published November 3, 2022
2. Byer AS, Pei X, Patterson MG, Ando N
Benchmarking AlphaFold2 on peptide structure prediction.
1. Structure - published November 3, 2022
2. McDonald EF, Jones T, Plate L, Meiler J, Gulsevin A
Interdomain Linkers Regulate Histidine Kinase Activity by Controlling Subunit Interactions.
1. Biochemistry - published November 2, 2022
2. Maschmann Z, Chandrasekaran S, Chua TK, Crane BR
Parallel functional annotation of cancer-associated missense mutations in histone methyltransferases.
1. Sci Rep - published November 2, 2022
2. Canning AJ, Viggiano S, Fernandez-Zapico ME, Cosgrove MS
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells.
1. Sci Rep - published November 2, 2022
2. Nguyenla X, Wehri E, Van Dis E, Biering SB, Yamashiro LH, Zhu C, Stroumza J, Dugast-Darzacq C, Graham TGW, Wang X, Jockusch S, Tao C, Chien M, Xie W, Patel DJ, Meyer C, Garzia A, Tuschl T, Russo JJ, Ju J, Näär AM, Stanley S, Schaletzky J
Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses.
1. Immunity - published November 2, 2022
2. Moin SM, Boyington JC, Boyoglu-Barnum S, Gillespie RA, Cerutti G, Cheung CS, Cagigi A, Gallagher JR, Brand J, Prabhakaran M, Tsybovsky Y, Stephens T, Fisher BE, Creanga A, Ataca S, Rawi R, Corbett KS, Crank MC, Karlsson Hedestam GB, Gorman J, McDermott AB, Harris AK, Zhou T, Kwong PD, Shapiro L, Mascola JR, Graham BS, Kanekiyo M
Grinding Temperature and Surface Integrity of Quenched Automotive Transmission Gear during the Form Grinding Process.
1. Materials (Basel) - published November 2, 2022
2. Jiang X, Liu K, Yan Y, Li M, Gong P, He H
Paeniclostridium sordellii uterine infection is dependent on the estrous cycle.
1. PLoS Pathog - published November 2, 2022
2. Bernard SC, Washington MK, Lacy DB
JAK-STAT signaling in inflammatory breast cancer enables chemotherapy-resistant cell states.
1. Cancer Res - published November 2, 2022
2. Stevens LE, Peluffo G, Qiu X, Temko D, Fassl A, Li Z, Trinh A, Seehawer M, Jovanovic B, Aleckovic M, Wilde CM, Geck RC, Shu S, Kingston NL, Harper NW, Almendro V, Pyke AL, Egri SB, Papanastasiou M, Clement K, Zhou N, Walker S, Salas J, Park SY, Frank DA, Meissner A, Jaffe JD, Sicinski P, Toker A, Michor F, Long HW, Overmoyer BA, Polyak K
Differential phosphorylation of Clr4^SUV39H by Cdk1 accompanies a histone H3 methylation switch that is essential for gametogenesis.
1. EMBO Rep - published November 2, 2022
2. Kuzdere T, Flury V, Schalch T, Iesmantavicius V, Hess D, Bühler M
Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo.
1. Proc Natl Acad Sci U S A - published November 2, 2022
2. Liu S, Yu Z, Daley EJ, Bingman CA, Bruchs AT, Gardella TJ, Gellman SH
Insights into distinct signaling profiles of the µOR activated by diverse agonists.
1. Nat Chem Biol - published November 2, 2022
2. Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G
A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins.
1. Nat Chem Biol - published November 2, 2022
2. Chonira V, Kwon YD, Gorman J, Case JB, Ku Z, Simeon R, Casner RG, Harris DR, Olia AS, Stephens T, Shapiro L, Bender MF, Boyd H, Teng IT, Tsybovsky Y, Krammer F, Zhang N, Diamond MS, Kwong PD, An Z, Chen Z
Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis.
1. Proc Natl Acad Sci U S A - published November 2, 2022
2. An SJ, Anneken A, Xi Z, Choi C, Schlessinger J, Toomre D
Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry.
1. Cell Rep - published November 2, 2022
2. Yu QC, Geng A, Preusch CB, Chen Y, Peng G, Xu Y, Jia Y, Miao Y, Xue H, Gao D, Bao L, Pan W, Chen J, Garcia KC, Cheung TH, Zeng YA
Development and Utility of a PAK1-Selective Degrader.
1. J Med Chem - published November 2, 2022
2. Chow HY, Karchugina S, Groendyke BJ, Toenjes S, Hatcher J, Donovan KA, Fischer ES, Abalakov G, Faezov B, Dunbrack R, Gray NS, Chernoff J
Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity.
1. Biochem J - published November 2, 2022
2. Bartzoka F, Gonzalez-Magaldi M, Byrne PO, Callery NI, Hristova K, Leahy DJ
Protection against SARS-CoV-2 Omicron BA.1 variant challenge in macaques by prime-boost vaccination with Ad26.COV2.S and SpFN.
1. Sci Adv - published November 2, 2022
2. Yu J, Thomas PV, McMahan K, Jacob-Dolan C, Liu J, He X, Hope D, Martinez EJ, Chen WH, Sciacca M, Hachmann NP, Lifton M, Miller J, Powers OC, Hall K, Wu C, Barrett J, Swafford I, Currier JR, King J, Corbitt C, Chang WC, Golub E, Rees PA, Peterson CE, Hajduczki A, Hussin E, Lange C, Gong H, Matyas GR, Rao M, Paquin-Proulx D, Gromowski GD, Lewis MG, Andersen H, Davis-Gardner M, Suthar MS, Michael NL, Bolton DL, Joyce MG, Modjarrad K, Barouch DH
Identification of transient intermediates during spliceosome activation by single molecule fluorescence microscopy.
1. Proc Natl Acad Sci U S A - published November 2, 2022
2. Fu X, Kaur H, Rodgers ML, Montemayor EJ, Butcher SE, Hoskins AA
NMR insights into dynamic, multivalent interactions of intrinsically disordered regions: from discrete complexes to condensates.
1. Essays Biochem - published November 2, 2022
2. Ahmed R, Forman-Kay JD
Structure of the NuA4 histone acetyltransferase complex.
1. Proc Natl Acad Sci U S A - published November 2, 2022
2. Ji L, Zhao L, Xu K, Gao H, Zhou Y, Kornberg RD, Zhang H
RNA-activated protein cleavage with a CRISPR-associated endopeptidase.
1. Science - published November 2, 2022
2. Strecker J, Demircioglu FE, Li D, Faure G, Wilkinson ME, Gootenberg JS, Abudayyeh OO, Nishimasu H, Macrae RK, Zhang F
Structure and function of the peroxisomal ubiquitin ligase complex.
1. Biochem Soc Trans - published November 2, 2022
2. Feng P, Skowyra ML, Rapoport TA
Structural basis for the assembly of the type V CRISPR-associated transposon complex.
1. Cell - published November 2, 2022
2. Schmitz M, Querques I, Oberli S, Chanez C, Jinek M
Structural basis for lipid and copper regulation of the ABC transporter MsbA.
1. Nat Commun - published November 2, 2022
2. Lyu J, Liu C, Zhang T, Schrecke S, Elam NP, Packianathan C, Hochberg GKA, Russell D, Zhao M, Laganowsky A
High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire.
1. PLoS Pathog - published November 2, 2022
2. Kucharska I, Binter Š, Murugan R, Scally SW, Ludwig J, Prieto K, Thai E, Costa G, Li K, Horn GQ, Flores-Garcia Y, Bosch A, Sicard T, Rubinstein JL, Zavala F, Dennison SM, Tomaras GD, Levashina EA, Kellam P, Wardemann H, Julien JP
Cryo-EM structures of the active NLRP3 inflammasome disk.
1. Nature - published November 2, 2022
2. Xiao L, Magupalli VG, Wu H
Distinct conformational and energetic features define the specific recognition of (di)aromatic peptide motifs by PEX14.
1. Biol Chem - published November 2, 2022
2. Gopalswamy M, Zheng C, Gaussmann S, Kooshapur H, Hambruch E, Schliebs W, Erdmann R, Antes I, Sattler M
Therapeutic targeting of LIF overcomes macrophage mediated immunosuppression of the local tumor microenvironment.
1. Clin Cancer Res - published November 2, 2022
2. Hallett R, Bonfill-Teixidor E, Iurlaro R, Arias A, Raman S, Bayliss PE, Egorova O, Neva-Alejo A, McGray AR, Lau E, Bosch A, Beilschmidt M, Maetzel D, Fransson J, Huber-Ruano I, Anido J, Julien JP, Giblin PA, Seoane J
Deep mutational scan of a drug efflux pump reveals its structure-function landscape.
1. Nat Chem Biol - published November 2, 2022
2. Meier G, Thavarasah S, Ehrenbolger K, Hutter CAJ, Hürlimann LM, Barandun J, Seeger MA
Non-Pharmaceutical Interventions Reduce the Incidence, and Mortality of COVID-19: A Study based on the Survey from the International COVID-19 Research Network (ICRN).
1. J Med Virol - published November 2, 2022
2. Park SH, Hong SH, Kim K, Lee SW, Yon DK, Jung SJ, Abdeen Z, Brahim Ahmed MLC, Serouri AA, Al-Herz W, Subbaram K, Shaik Syed P, Ali S, Ali K, Al-Shamsi HO, Baatarkhuu O, Nielsen HB, Bernini-Carri E, Bondarenko A, Cassell A, Cham A, Chua ML, Dadabhai S, Darre T, Davtyan H, Dragioti E, East B, Jeffrey Edwards R, Ferioli M, Georgiev T, Ghandour L, Harapan H, Hsueh PR, Ikram A, Inoue S, Jacob L, Janković S, Jayarajah U, Jesenak M, Kakodkar P, Kapata N, Kebede Y, Khader Y, Kifle M, Koh D, Maleš VK, Kotfis K, Koyanagi A, Kretchy JP, Lakoh S, Lee J, Lee JY, Mendonça MDLL, Ling L, Llibre-Guerra J, Machida M, Makurumidze R, Mallah S, Memish ZA, Mendoza I, Moiseev S, Nadasdy T, Nahshon C, Ñamendys-Silva SA, Yongsi BN, Nicolasora AD, Nugmanova Z, Oh H, Oksanen A, Owopetu O, Ozguler ZO, Perez GE, Pongpirul K, Rademaker M, Radojevic N, Roca A, Rodriguez-Morales AJ, Viveiros Rosa SG, Roshi E, Saeed KMI, Sah R, Sakakushev B, Sallam DE, Sathian B, Schober P, Simonović Z, Singhal T, Skhvitaridze N, Solmi M, Tizaoui K, Tlhakanelo JT, Torales J, Torres-Roman S, Tsartsalis D, Tsolmon J, Vieira DN, Wanghi G, Wollina U, Xu RH, Yang L, Zia K, Zildzic M, Il Shin J, Smith L
Substrate-selective small-molecule modulators of enzymes: Mechanisms and opportunities.
1. Curr Opin Chem Biol - published November 2, 2022
2. Lin H
Bacterial origins of cyclic nucleotide-activated antiviral immune signaling.
1. Mol Cell - published November 2, 2022
2. Patel DJ, Yu Y, Jia N
Interactions of Candida tropicalis pH-related antigen 1 with complement proteins C3, C3b, factor-H, C4BP and complement evasion.
1. Immunobiology - published November 2, 2022
2. Valand N, Gazioglu O, Yesilkaya H, Shivkumar M, Horley N, Arroo R, Wallis R, Kishore U, Venkatraman Girija U
Conjunctival Swabs Reveal Higher Detection Rate Compared to Schirmer Strips for SARS-CoV-2 RNA Detection in Tears of Hospitalized COVID-19 Patients.
1. J Clin Med - published November 2, 2022
2. Sabage LE, Sun YJ, Wolf J, Sabage J, Mazzo A, Santos CF, Mahajan VB, Manzoni Lourençone LF
PEBAT, an Intriguing Neurodegenerative Tubulinopathy Caused by a Novel Homozygous Variant in TBCD: A Case Series and Literature Review.
1. Pediatr Neurol - published November 2, 2022
2. Ocampo-Chih C, Dennis H, Lall N, Pham N, Liang B, Verma S, Neira Fresneda J
A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage.
1. EMBO J - published November 1, 2022
2. Lau RK, Enustun E, Gu Y, Nguyen JV, Corbett KD
Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial.
1. Nat Med - published November 1, 2022
2. Gunst JD, Pahus MH, Rosás-Umbert M, Lu IN, Benfield T, Nielsen H, Johansen IS, Mohey R, Østergaard L, Klastrup V, Khan M, Schleimann MH, Olesen R, Støvring H, Denton PW, Kinloch NN, Copertino DC, Ward AR, Alberto WDC, Nielsen SD, Puertas MC, Ramos V, Reeves JD, Petropoulos CJ, Martinez-Picado J, Brumme ZL, Jones RB, Fox J, Tolstrup M, Nussenzweig MC, Caskey M, Fidler S, Søgaard OS
Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
1. Proc Natl Acad Sci U S A - published November 1, 2022
2. Chen Z, Zakrzewska S, Hajare HS, Alvarez-Buylla A, Abderemane-Ali F, Bogan M, Ramirez D, O'Connell LA, Du Bois J, Minor DL Jr
Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175.
1. Proc Natl Acad Sci U S A - published November 1, 2022
2. Oh S, Stix R, Zhou W, Faraldo-Gómez JD, Hite RK
Mechanism of voltage gating in the voltage-sensing phosphatase Ci-VSP.
1. Proc Natl Acad Sci U S A - published November 1, 2022
2. Shen R, Meng Y, Roux B, Perozo E
ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit.
1. Proc Natl Acad Sci U S A - published November 1, 2022
2. Riella CV, McNulty M, Ribas GT, Tattersfield CF, Perez-Gill C, Eichinger F, Kelly J, Chun J, Subramanian B, Guizelini D, Nephrotic Syndrome Study Network (NEPTUNE)., Alper SL, Pollak MR, Sampson MG, Friedman DJ
ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins.
1. Mol Cell - published November 1, 2022
2. McKenna MJ, Adams BM, Chu V, Paulo JA, Shao S
Inline SAXS-coupled chromatography under extreme hydrostatic pressure.
1. Protein Sci - published November 1, 2022
2. Miller RC, Cummings C, Huang Q, Ando N, Gillilan RE
Characterization of heterogeneity in nanodisc samples using Feret signatures.
1. J Struct Biol - published November 1, 2022
2. Vilela F, Bezault A, Rodriguez de Francisco B, Sauvanet C, Xu XP, Swift MF, Yao Y, Marrasi FM, Hanein D, Volkmann N
Voltage-sensor movements in the Eag Kv channel under an applied electric field.
1. Proc Natl Acad Sci U S A - published November 1, 2022
2. Mandala VS, MacKinnon R
Molecular characterization of recombinant premembrane protein of dengue virus serotype-2 for development of diagnostic assay.
1. J Basic Microbiol - published November 1, 2022
2. Munir R, Rafique S, Ali A, Amin I, Ahmed S, Vajeeha A, Shahid M, Samiullah TR, Idrees M, Tao YJ, Khan MU
Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations.
1. Nat Commun - published November 1, 2022
2. van Alderwerelt van Rosenburgh IK, Lu DM, Grant MJ, Stayrook SE, Phadke M, Walther Z, Goldberg SB, Politi K, Lemmon MA, Ashtekar KD, Tsutsui Y
Structures of a mobile intron retroelement poised to attack its structured DNA target.
1. Science - published November 1, 2022
2. Chung K, Xu L, Chai P, Peng J, Devarkar SC, Pyle AM
Dual Inhibitors of Main Protease (M^Pro) and Cathepsin L as Potent Antivirals against SARS-CoV2.
1. J Am Chem Soc - published November 1, 2022
2. Mondal S, Chen Y, Lockbaum GJ, Sen S, Chaudhuri S, Reyes AC, Lee JM, Kaur AN, Sultana N, Cameron MD, Shaffer SA, Schiffer CA, Fitzgerald KA, Thompson PR
Magic-angle-spinning NMR structure of the kinesin-1 motor domain assembled with microtubules reveals the elusive neck linker orientation.
1. Nat Commun - published November 1, 2022
2. Zhang C, Guo C, Russell RW, Quinn CM, Li M, Williams JC, Gronenborn AM, Polenova T
Inhibition of a malaria host-pathogen interaction by a computationally designed inhibitor.
1. Protein Sci - published November 1, 2022
2. Tobin AR, Crow R, Urusova DV, Klima JC, Tolia NH, Strauch EM
A Multiplexed Cas13-Based Assay with Point-of-Care Attributes for Simultaneous COVID-19 Diagnosis and Variant Surveillance.
1. CRISPR J - published November 1, 2022
2. Patchsung M, Homchan A, Aphicho K, Suraritdechachai S, Wanitchanon T, Pattama A, Sappakhaw K, Meesawat P, Wongsatit T, Athipanyasilp A, Jantarug K, Athipanyasilp N, Buahom J, Visanpattanasin S, Niljianskul N, Chaiyen P, Tinikul R, Wichukchinda N, Mahasirimongkol S, Sirijatuphat R, Angkasekwinai N, Crone MA, Freemont PS, Joung J, Ladha A, Abudayyeh O, Gootenberg J, Zhang F, Chewapreecha C, Chanarat S, Horthongkham N, Pakotiprapha D, Uttamapinant C
MEPSi: A tool for simulating tomograms of membrane-embedded proteins.
1. J Struct Biol - published November 1, 2022
2. Rodríguez de Francisco B, Bezault A, Xu XP, Hanein D, Volkmann N
Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel.
1. Nat Commun - published November 1, 2022
2. Mount J, Maksaev G, Summers BT, Fitzpatrick JAJ, Yuan P
Constructing next-generation CRISPR-Cas tools from structural blueprints.
1. Curr Opin Biotechnol - published November 1, 2022
2. Bravo JP, Hibshman GN, Taylor DW
Knockdown of hsa_circ_0043691 restrains the progression of gastric cancer by decoying miR-1294 to target pre-leukemia transcription factor 3.
1. J Clin Lab Anal - published November 1, 2022
2. Wu J, Gong P, Jiang Z
Editorial overview: Catalysis and regulation: The chemistry of catalysis.
1. Curr Opin Struct Biol - published November 1, 2022
2. Scrutton NS, Fujimori DG
Primary Aldosteronism and the Role of Mineralocorticoid Receptor Antagonists for the Heart and Kidneys.
1. Annu Rev Med - published November 1, 2022
2. Cohen JB, Bancos I, Brown JM, Sarathy H, Turcu AF, Cohen DL
Multivalent S2-based vaccines provide broad protection against SARS-CoV-2 variants of concern and pangolin coronaviruses.
1. EBioMedicine - published November 1, 2022
2. Halfmann PJ, Frey SJ, Loeffler K, Kuroda M, Maemura T, Armbrust T, Yang JE, Hou YJ, Baric R, Wright ER, Kawaoka Y, Kane RS
Hezi inhibits Tiebangchui-induced cardiotoxicity and preserves its anti-rheumatoid arthritis effects by regulating the pharmacokinetics of aconitine and deoxyaconitine.
1. J Ethnopharmacol - published November 1, 2022
2. Liu X, Tao H, Tian R, Huang W, Zhang T, Liu Y, Zhang Y, Meng X
Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity.
1. Nat Commun - published November 1, 2022
2. Yin M, Kuang W, Wang Q, Wang X, Yuan C, Lin Z, Zhang H, Deng F, Jiang H, Gong P, Zou Z, Hu Z, Wang M
Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop.
1. Nat Commun - published November 1, 2022
2. Mills CE, Subramanian K, Hafner M, Niepel M, Gerosa L, Chung M, Victor C, Gaudio B, Yapp C, Nirmal AJ, Clark N, Sorger PK
Engineering a Conformationally Switchable Artificial Metalloprotein.
1. J Am Chem Soc - published November 1, 2022
2. Fatima S, Boggs DG, Ali N, Thompson PJ, Thielges MC, Bridwell-Rabb J, Olshansky L
Structural analysis of Plasmodium falciparum ookinete surface antigen Pfs28 relevant for malaria vaccine design.
1. Sci Rep - published November 1, 2022
2. Shukla N, Tang WK, Tolia NH
Publisher Correction: Potentiating adoptive cell therapy using synthetic IL-9 receptors.
1. Nature - published November 1, 2022
2. Kalbasi A, Siurala M, Su LL, Tariveranmoshabad M, Picton LK, Ravikumar P, Li P, Lin JX, Escuin-Ordinas H, Da T, Kremer SV, Sun AL, Castelli S, Agarwal S, Scholler J, Song D, Rommel PC, Radaelli E, Young RM, Leonard WJ, Ribas A, June CH, Garcia KC
Chaperone-mediated autophagy regulates adipocyte differentiation.
1. Sci Adv - published November 1, 2022
2. Kaushik S, Juste YR, Lindenau K, Dong S, Macho-González A, Santiago-Fernández O, McCabe M, Singh R, Gavathiotis E, Cuervo AM
Defocus corrected large area cryo-EM (DeCo-LACE) for label-free detection of molecules across entire cell sections.
1. Elife - published November 1, 2022
2. Elferich J, Schiroli G, Scadden D, Grigorieff N
Antibodies as drugs-a Keystone Symposia report.
1. Ann N Y Acad Sci - published November 1, 2022
2. Cable J, Saphire EO, Hayday AC, Wiltshire TD, Mousa JJ, Humphreys DP, Breij ECW, Bruhns P, Broketa M, Furuya G, Hauser BM, Mahévas M, Carfi A, Cantaert T, Kwong PD, Tripathi P, Davis JH, Brewis N, Keyt BA, Fennemann FL, Dussupt V, Sivasubramanian A, Kim PM, Rawi R, Richardson E, Leventhal D, Wolters RM, Geuijen CAW, Sleeman MA, Pengo N, Donnellan FR
Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
1. J Med Chem - published November 1, 2022
2. Amrhein JA, Beyett TS, Feng WW, Krämer A, Weckesser J, Schaeffner IK, Rana JK, Jänne PA, Eck MJ, Knapp S, Hanke T
Somatosensory cortical signature of facial nociception and vibrotactile touch-induced analgesia.
1. Sci Adv - published November 1, 2022
2. Lu J, Chen B, Levy M, Xu P, Han BX, Takatoh J, Thompson PM, He Z, Prevosto V, Wang F
Advancing New Chemical Modalities into Clinical Studies.
1. ACS Med Chem Lett - published November 1, 2022
2. Blanco MJ, Gardinier KM, Namchuk MN
Covalent Modification of the JH2 Domain of Janus Kinase 2.
1. ACS Med Chem Lett - published November 1, 2022
2. Henry SP, Liosi ME, Ippolito JA, Menges F, Newton AS, Schlessinger J, Jorgensen WL
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.
1. Nature - published November 1, 2022
2. Blanchard JW, Akay LA, Davila-Velderrain J, von Maydell D, Mathys H, Davidson SM, Effenberger A, Chen CY, Maner-Smith K, Hajjar I, Ortlund EA, Bula M, Agbas E, Ng A, Jiang X, Kahn M, Blanco-Duque C, Lavoie N, Liu L, Reyes R, Lin YT, Ko T, R'Bibo L, Ralvenius WT, Bennett DA, Cam HP, Kellis M, Tsai LH
Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4).
1. Commun Biol - published November 1, 2022
2. Ha BH, Yigit S, Natarajan N, Morse EM, Calderwood DA, Boggon TJ
Structure determination of inactive-state GPCRs with a universal nanobody.
1. Nat Struct Mol Biol - published November 1, 2022
2. Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G
The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI.
1. Biochem Soc Trans - published November 1, 2022
2. Lyumkis D, Horton NC
UnMICST: Deep learning with real augmentation for robust segmentation of highly multiplexed images of human tissues.
1. Commun Biol - published November 1, 2022
2. Yapp C, Novikov E, Jang WD, Vallius T, Chen YA, Cicconet M, Maliga Z, Jacobson CA, Wei D, Santagata S, Pfister H, Sorger PK
Rho family GTPase signaling through type II p21-activated kinases.
1. Cell Mol Life Sci - published November 1, 2022
2. Chetty AK, Ha BH, Boggon TJ
Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state.
1. Nat Commun - published November 1, 2022
2. Maiti A, Hedger AK, Myint W, Balachandran V, Watts JK, Schiffer CA, Matsuo H
PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation.
1. Nat Commun - published November 1, 2022
2. Madsen MS, Broekema MF, Madsen MR, Koppen A, Borgman A, Gräwe C, Thomsen EGK, Westland D, Kranendonk MEG, Koerkamp MG, Hamers N, Bonvin AMJJ, Pittol JMR, Natarajan KN, Kersten S, Holstege FCP, Monajemi H, van Mil SWC, Vermeulen M, Kragelund BB, Cassiman D, Mandrup S, Kalkhoven E
Structure of the human heparan sulfate polymerase complex EXT1-EXT2.
1. Nat Commun - published November 1, 2022
2. Leisico F, Omeiri J, Le Narvor C, Beaudouin J, Hons M, Fenel D, Schoehn G, Couté Y, Bonnaffé D, Sadir R, Lortat-Jacob H, Wild R
Engineering Rieske oxygenase activity one piece at a time.
1. Curr Opin Chem Biol - published November 1, 2022
2. Brimberry M, Garcia AA, Liu J, Tian J, Bridwell-Rabb J
Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP.
1. Structure - published November 1, 2022
2. Stiegler AL, Vish KJ, Boggon TJ
Assessment of Crosslinkers between Peptide Antigen and Carrier Protein for Fusion Peptide-Directed Vaccines against HIV-1.
1. Vaccines (Basel) - published November 1, 2022
2. Ou L, Gulla K, Biju A, Biner DW, Bylund T, Changela A, Chen SJ, Zheng CY, Cibelli N, Corrigan AR, Duan H, Gonelli CA, Kong WP, Cheng C, O'Dell S, Sarfo EK, Shaddeau A, Wang S, Vinitsky A, Yang Y, Zhang B, Zhang Y, Koup RA, Doria-Rose NA, Gall JG, Mascola JR, Kwong PD
Activating charge-transfer state formation in strongly-coupled dimers using DNA scaffolds.
1. Chem Sci - published November 1, 2022
2. Hart SM, Banal JL, Castellanos MA, Markova L, Vyborna Y, Gorman J, Häner R, Willard AP, Bathe M, Schlau-Cohen GS
A focus on the discovery of potent and selective cyclic peptide scaffolds for drug development.
1. Chem Sci - published November 1, 2022
2. Saunders GJ, Yudin AK
Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease.
1. Bioorg Chem - published November 1, 2022
2. Zephyr J, Rao DN, Johnson C, Shaqra AM, Nalivaika EA, Jordan A, Kurt Yilmaz N, Ali A, Schiffer CA