Member Publications

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134 Member Publications for June 2022

Assessment of the Characteristics of Waxy Rice Mutants Generated by CRISPR/Cas9.
1. Front Plant Sci - published June 27, 2022
2. Fu Y, Luo T, Hua Y, Yan X, Liu X, Liu Y, Liu Y, Zhang B, Liu R, Zhu Z, Zhu J
Computational Structure Prediction for Antibody-Antigen Complexes From Hydrogen-Deuterium Exchange Mass Spectrometry: Challenges and Outlook.
1. Front Immunol - published June 20, 2022
2. Tran MH, Schoeder CT, Schey KL, Meiler J
Biochemical and structural characterization of the flavodoxin-like domain of the Schizosaccharomyces japonicus putative tRNA ^Phe 4-demethylwyosine synthase Tyw1 in complex with FMN.
1. MicroPubl Biol - published June 13, 2022
2. Sjekloća L, Ferré-D'Amaré AR
Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold.
1. Science - published June 10, 2022
2. Fontana P, Dong Y, Pi X, Tong AB, Hecksel CW, Wang L, Fu TM, Bustamante C, Wu H
The eIF4A Inhibitor Silvestrol Blocks the Growth of Human Glioblastoma Cells by Inhibiting AKT/mTOR and ERK1/2 Signaling Pathway.
1. J Oncol - published June 9, 2022
2. Zhang W, Gong P, Tian Q, Han S, Wang J, He P, Guo Y, Wang G, Chen Q, Huang J, Li M
Structural Basis for pH-gating of the K⁺ channel TWIK1 at the selectivity filter.
1. Nat Commun - published June 9, 2022
2. Turney TS, Li V, Brohawn SG
Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex.
1. Cell - published June 9, 2022
2. Puno MR, Lima CD
Forced entry into the nucleus.
1. Nat Cell Biol - published June 9, 2022
2. Petrovic S, Hoelz A
Characterization of Protein-Membrane Interactions in Yeast Autophagy.
1. Cells - published June 9, 2022
2. Leary KA, Ragusa MJ
A rapid and sensitive assay for quantifying the activity of both aerobic and anaerobic ribonucleotide reductases acting upon any or all substrates.
1. PLoS One - published June 8, 2022
2. Levitz TS, Andree GA, Jonnalagadda R, Dawson CD, Bjork RE, Drennan CL
Sequence-specific ¹H, ¹³C and ¹⁵N backbone NMR assignments for the N-terminal IgV-like domain (D1) and full extracellular region (D1D2) of PD-L1.
1. Biomol NMR Assign - published June 8, 2022
2. Walker K, Waters LC, Kelly G, Muskett FW, Carr MD
Potentiating adoptive cell therapy using synthetic IL-9 receptors.
1. Nature - published June 8, 2022
2. Kalbasi A, Siurala M, Su LL, Tariveranmoshabad M, Picton LK, Ravikumar P, Li P, Lin JX, Escuin-Ordinas H, Da T, Kremer SV, Sun AL, Castelli S, Agarwal S, Scholler J, Song D, Rommel PC, Radaelli E, Young RM, Leonard WJ, Ribas A, June CH, Garcia KC
Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals.
1. Nat Commun - published June 8, 2022
2. Bozhanova NG, Flyak AI, Brown BP, Ruiz SE, Salas J, Rho S, Bombardi RG, Myers L, Soto C, Bailey JR, Crowe JE Jr, Bjorkman PJ, Meiler J
Dental pulp stem cell transplantation facilitates neuronal neuroprotection following cerebral ischemic stroke.
1. Biomed Pharmacother - published June 8, 2022
2. Gong P, Tian Q, He Y, He P, Wang J, Guo Y, Ye Q, Li M
Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike.
1. Cell Rep - published June 8, 2022
2. Stalls V, Lindenberger J, Gobeil SM, Henderson R, Parks R, Barr M, Deyton M, Martin M, Janowska K, Huang X, May A, Speakman M, Beaudoin E, Kraft B, Lu X, Edwards RJ, Eaton A, Montefiori DC, Williams WB, Saunders KO, Wiehe K, Haynes BF, Acharya P
Navigating complex peptide structures using macrocycle conformational maps.
1. RSC Chem Biol - published June 8, 2022
2. McTiernan TJ, Diaz DB, Saunders GJ, Sprang F, Yudin AK
Human pathogenic RNA viruses establish noncompeting lineages by occupying independent niches.
1. Proc Natl Acad Sci U S A - published June 7, 2022
2. Mutz P, Rochman ND, Wolf YI, Faure G, Zhang F, Koonin EV
Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes.
1. Proc Natl Acad Sci U S A - published June 7, 2022
2. Yu Y, Li S, Ser Z, Kuang H, Than T, Guan D, Zhao X, Patel DJ
Molecular determinants of inhibition of the human proton channel hHv1 by the designer peptide C6 and a bivalent derivative.
1. Proc Natl Acad Sci U S A - published June 7, 2022
2. Zhao R, Shen R, Dai H, Perozo E, Goldstein SAN
Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses.
1. Annu Rev Virol - published June 7, 2022
2. Rosenkilde MM, Tsutsumi N, Knerr JM, Kildedal DF, Garcia KC
Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling.
1. Biochem J - published June 7, 2022
2. Javorsky A, Humbert PO, Kvansakul M
Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS.
1. EMBO J - published June 7, 2022
2. Hertzog J, Zhou W, Fowler G, Rigby RE, Bridgeman A, Blest HT, Cursi C, Chauveau L, Davenne T, Warner BE, Kinchington PR, Kranzusch PJ, Rehwinkel J
pH- and concentration-dependent supramolecular assembly of a fungal defensin plectasin variant into helical non-amyloid fibrils.
1. Nat Commun - published June 7, 2022
2. Pohl C, Effantin G, Kandiah E, Meier S, Zeng G, Streicher W, Segura DR, Mygind PH, Sandvang D, Nielsen LA, Peters GHJ, Schoehn G, Mueller-Dieckmann C, Noergaard A, Harris P
Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides.
1. Chem Sci - published June 7, 2022
2. Zhang MY, Yang H, Ortiz G, Trnka MJ, Petronikolou N, Burlingame AL, DeGrado WF, Fujimori DG
Structural and biochemical insights into lipid transport by VPS13 proteins.
1. J Cell Biol - published June 6, 2022
2. Adlakha J, Hong Z, Li P, Reinisch KM
A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes.
1. J Exp Med - published June 6, 2022
2. Bastard P, Hsiao KC, Zhang Q, Choin J, Best E, Chen J, Gervais A, Bizien L, Materna M, Harmant C, Roux M, Hawley NL, Weeks DE, McGarvey ST, Sandoval K, Barberena-Jonas C, Quinto-Cortés CD, Hagelberg E, Mentzer AJ, Robson K, Coulibaly B, Seeleuthner Y, Bigio B, Li Z, Uzé G, Pellegrini S, Lorenzo L, Sbihi Z, Latour S, Besnard M, Adam de Beaumais T, Jacqz Aigrain E, Béziat V, Deka R, Esera Tulifau L, Viali S, Reupena MS, Naseri T, McNaughton P, Sarkozy V, Peake J, Blincoe A, Primhak S, Stables S, Gibson K, Woon ST, Drake KM, Hill AVS, Chan CY, King R, Ameratunga R, Teiti I, Aubry M, Cao-Lormeau VM, Tangye SG, Zhang SY, Jouanguy E, Gray P, Abel L, Moreno-Estrada A, Minster RL, Quintana-Murci L, Wood AC, Casanova JL
SHIP164 is a chorein motif lipid transfer protein that controls endosome-Golgi membrane traffic.
1. J Cell Biol - published June 6, 2022
2. Hanna MG, Suen PH, Wu Y, Reinisch KM, De Camilli P
Microenvironment-Sensitive Fluorescent Nucleotide Probes from Benzofuran, Benzothiophene, and Selenophene as Substrates for DNA Polymerases.
1. J Am Chem Soc - published June 6, 2022
2. Ghosh P, Kropp HM, Betz K, Ludmann S, Diederichs K, Marx A, Srivatsan SG
Antibody binding modulates the dynamics of the membrane bound prion protein.
1. Biophys J - published June 6, 2022
2. Ilie IM, Bacci M, Vitalis A, Caflisch A
3D cryo-electron microscopic imaging of bacterial flagella: novel structural and mechanistic insights into cell motility.
1. J Biol Chem - published June 4, 2022
2. Mondino S, San Martin F, Buschiazzo A
Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design.
1. Biochemistry - published June 3, 2022
2. Michel E, Cucuzza S, Mittl PRE, Zerbe O, Plückthun A
Extended conformational states dominate the Hsp90 chaperone dynamics.
1. J Biol Chem - published June 3, 2022
2. Jussupow A, Lopez A, Baumgart M, Mader SL, Sattler M, Kaila VRI
mRNA vaccine boosting enhances antibody responses against SARS-CoV-2 Omicron variant in individuals with antibody deficiency syndromes.
1. Cell Rep Med - published June 3, 2022
2. Zimmerman O, Altman Doss AM, Kaplonek P, Liang CY, VanBlargan LA, Chen RE, Monroy JM, Wedner HJ, Kulczycki A Jr, Mantia TL, O'Shaughnessy CC, Davis-Adams HG, Bertera HL, Adams LJ, Raju S, Zhao FR, Rigell CJ, Dy TB, Kau AL, Ren Z, Turner JS, O'Halloran JA, Presti RM, Fremont DH, Kendall PL, Ellebedy AH, Alter G, Diamond MS
Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.
1. Nat Commun - published June 3, 2022
2. Miller PG, Sathappa M, Moroco JA, Jiang W, Qian Y, Iqbal S, Guo Q, Giacomelli AO, Shaw S, Vernier C, Bajrami B, Yang X, Raffier C, Sperling AS, Gibson CJ, Kahn J, Jin C, Ranaghan M, Caliman A, Brousseau M, Fischer ES, Lintner R, Piccioni F, Campbell AJ, Root DE, Garvie CW, Ebert BL
A natural fusion of flavodiiron, rubredoxin, and rubredoxin oxidoreductase domains is a self-sufficient water-forming oxidase of Trichomonas vaginalis.
1. J Biol Chem - published June 3, 2022
2. Abdulaziz EN, Bell TA, Rashid B, Heacock ML, Begic T, Skinner OS, Yaseen MA, Chao LH, Mootha VK, Pierik AJ, Cracan V
Neutralizing COVID-19 Convalescent Plasma in Adults Hospitalized with COVID-19: A Blinded Randomized Placebo-Controlled Trial.
1. Chest - published June 3, 2022
2. Self WH, Wheeler AP, Stewart TG, Schrager H, Mallada J, Thomas CB, Cataldo VD, O'Neal HR Jr, Shapiro NI, Higgins C, Ginde AA, Chauhan L, Johnson NJ, Henning DJ, Jaiswal SJ, Mammen MJ, Harris ES, Pannu SR, Laguio-Vila M, El Atrouni W, de Wit M, Hoda D, Cohn CS, McWilliams C, Shanholtz C, Jones AE, Raval JS, Mucha S, Ipe TS, Qiao X, Schrantz SJ, Shenoy A, Fremont RD, Brady EJ, Carnahan RH, Chappell JD, Crowe JE Jr, Denison MR, Gilchuk P, Stevens LJ, Sutton RE, Thomsen I, Yoder SM, Bistran-Hall AJ, Casey JD, Lindsell CJ, Wang L, Pulley JM, Rhoads JP, Bernard GR, Rice TW, Passive Immunity Trial for Our Nation (PassITON) Investigators.
African Americans and the COVID-19 pandemic: A qualitative inquiry of preparedness, challenges, and strategies on how we can move forward.
1. Soc Sci Med - published June 3, 2022
2. Cunningham-Erves J, Parham I, Alexander L, Moss J, Barre I, Gillyard T, Davis J
Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands.
1. J Med Chem - published June 2, 2022
2. Liosi ME, Ippolito JA, Henry SP, Krimmer SG, Newton AS, Cutrona KJ, Olivarez RA, Mohanty J, Schlessinger J, Jorgensen WL
Cyclization and Docking Protocol for Cyclic Peptide-Protein Modeling Using HADDOCK2.4.
1. J Chem Theory Comput - published June 2, 2022
2. Charitou V, van Keulen SC, Bonvin AMJJ
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination.
1. Genes Dev - published June 2, 2022
2. Gao Y, Barajas-Ornelas RDC, Amon JD, Ramírez-Guadiana FH, Alon A, Brock KP, Marks DS, Kruse AC, Rudner DZ
Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress.
1. Nat Cancer - published June 2, 2022
2. Liu X, Viswanadhapalli S, Kumar S, Lee TK, Moore A, Ma S, Chen L, Hsieh M, Li M, Sareddy GR, Parra K, Blatt EB, Reese TC, Zhao Y, Chang A, Yan H, Xu Z, Pratap UP, Liu Z, Roggero CM, Tan Z, Weintraub ST, Peng Y, Tekmal RR, Arteaga CL, Lippincott-Schwartz J, Vadlamudi RK, Ahn JM, Raj GV
Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
1. Nat Struct Mol Biol - published June 2, 2022
2. Arrigoni C, Lolicato M, Shaya D, Rohaim A, Findeisen F, Fong LK, Colleran CM, Dominik P, Kim SS, Schuermann JP, DeGrado WF, Grabe M, Kossiakoff AA, Minor DL Jr
Structural basis for ultrapotent antibody-mediated neutralization of human metapneumovirus.
1. Proc Natl Acad Sci U S A - published June 2, 2022
2. Banerjee A, Huang J, Rush SA, Murray J, Gingerich AD, Royer F, Hsieh CL, Tripp RA, McLellan JS, Mousa JJ
Mechanism of voltage sensing in Ca²⁺- and voltage-activated K⁺ (BK) channels.
1. Proc Natl Acad Sci U S A - published June 2, 2022
2. Carrasquel-Ursulaez W, Segura I, Díaz-Franulic I, Echeverría F, Lorenzo-Ceballos Y, Espinoza N, Rojas M, Garate JA, Perozo E, Alvarez O, Gonzalez-Nilo FD, Latorre R
Comprehensive fitness landscape of SARS-CoV-2 M^pro reveals insights into viral resistance mechanisms.
1. Elife - published June 2, 2022
2. Flynn JM, Samant N, Schneider-Nachum G, Bakan DT, Yilmaz NK, Schiffer CA, Moquin SA, Dovala D, Bolon DNA
Hiding in plain sight: three chemically distinct α-helix types.
1. Q Rev Biophys - published June 2, 2022
2. Zhang S, Egli M
Structure and Evolution of Neuronal Wiring Receptors and Ligands.
1. Dev Dyn - published June 2, 2022
2. Cortés E, Pak JS, Özkan E
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
1. Nat Commun - published June 2, 2022
2. Shaqra AM, Zvornicanin SN, Huang QYJ, Lockbaum GJ, Knapp M, Tandeske L, Bakan DT, Flynn J, Bolon DNA, Moquin S, Dovala D, Kurt Yilmaz N, Schiffer CA
Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants.
1. ACS Chem Biol - published June 2, 2022
2. Labriola JM, Miersch S, Chen G, Chen C, Pavlenco A, Saberianfar R, Caccuri F, Zani A, Sharma N, Feng A, Leung DW, Caruso A, Novelli G, Amarasinghe GK, Sidhu SS
Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers.
1. Elife - published June 2, 2022
2. Belyy V, Zuazo-Gaztelu I, Alamban A, Ashkenazi A, Walter P
Elicitation of pneumovirus-specific B cell responses by a prefusion-stabilized respiratory syncytial virus F subunit vaccine.
1. Sci Transl Med - published June 2, 2022
2. Phung E, Chang LA, Mukhamedova M, Yang L, Nair D, Rush SA, Morabito KM, McLellan JS, Buchholz UJ, Mascola JR, Crank MC, Chen G, Graham BS, Ruckwardt TJ
Distinctive features of the respiratory syncytial virus priming loop compared to other non-segmented negative strand rna viruses.
1. PLoS Pathog - published June 2, 2022
2. Cressey TN, Shareef AM, Kleiner VA, Noton SL, Byrne PO, McLellan JS, Muhlberger E, Fearns R
A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA.
1. Elife - published June 2, 2022
2. Liu X, Gaubitz C, Pajak J, Kelch BA
Imaging joint infections using D-methyl-¹¹C-methionine PET/MRI: initial experience in humans.
1. Eur J Nucl Med Mol Imaging - published June 2, 2022
2. Polvoy I, Seo Y, Parker M, Stewart M, Siddiqua K, Manacsa HS, Ravanfar V, Blecha J, Hope TA, Vanbrocklin H, Flavell RR, Barry J, Hansen E, Villanueva-Meyer JE, Engel J, Rosenberg OS, Wilson DM, Ohliger MA
Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation.
1. Proc Natl Acad Sci U S A - published June 2, 2022
2. Page JE, Skiba MA, Do T, Kruse AC, Walker S
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.
1. Nucleic Acids Res - published June 2, 2022
2. Schlegel MK, Janas MM, Jiang Y, Barry JD, Davis W, Agarwal S, Berman D, Brown CR, Castoreno A, LeBlanc S, Liebow A, Mayo T, Milstein S, Nguyen T, Shulga-Morskaya S, Hyde S, Schofield S, Szeto J, Woods LB, Yilmaz VO, Manoharan M, Egli M, Charissé K, Sepp-Lorenzino L, Haslett P, Fitzgerald K, Jadhav V, Maier MA
Therapeutic Inhibition of Staphylococcus aureus ArlRS Two-Component Regulatory System Blocks Virulence.
1. Antimicrob Agents Chemother - published June 2, 2022
2. Kwiecinski JM, Jelani DA, Fuentes EJ, Horswill AR
Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes.
1. Elife - published June 2, 2022
2. Doherty LM, Mills CE, Boswell SA, Liu X, Hoyt CT, Gyori B, Buhrlage SJ, Sorger PK
Pathogen-sugar interactions revealed by universal saturation transfer analysis.
1. Science - published June 2, 2022
2. Buchanan CJ, Gaunt B, Harrison PJ, Yang Y, Liu J, Khan A, Giltrap AM, Le Bas A, Ward PN, Gupta K, Dumoux M, Tan TK, Schimaski L, Daga S, Picchiotti N, Baldassarri M, Benetti E, Fallerini C, Fava F, Giliberti A, Koukos PI, Davy MJ, Lakshminarayanan A, Xue X, Papadakis G, Deimel LP, Casablancas-Antràs V, Claridge TDW, Bonvin AMJJ, Sattentau QJ, Furini S, Gori M, Huo J, Owens RJ, Schaffitzel C, Berger I, Renieri A, GEN-COVID Multicenter Study., Naismith JH, Baldwin AJ, Davis BG
Using Champion-Oriented Mindset to Overcome the Challenges of Graduate School: Impact of Workshop for Graduate School Skills on Underrepresented Minority Retention.
1. Pathog Dis - published June 2, 2022
2. Marshall AG, Palavicino-Maggio CB, Neikirk K, Vue Z, Beasley HK, Garza-Lopez E, Murray SA, Martinez D, Crabtree A, Conley ZC, Vang L, Davis JS, Powell-Roach KL, Campbell S, Dal AB, Shao B, Alexander S, Vang N, Vue N, Vue M, Shuler HD, Spencer EC, Morton DJ, Hinton A
Structural and cellular basis of vitamin K antagonism.
1. J Thromb Haemost - published June 2, 2022
2. Liu S, Shen G, Li W
Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function.
1. Nat Commun - published June 2, 2022
2. Sheikh MO, Capicciotti CJ, Liu L, Praissman J, Ding D, Mead DG, Brindley MA, Willer T, Campbell KP, Moremen KW, Wells L, Boons GJ
The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy.
1. Nat Commun - published June 2, 2022
2. van der Grein SG, Defourny KAY, Rabouw HH, Goerdayal SS, van Herwijnen MJC, Wubbolts RW, Altelaar M, van Kuppeveld FJM, Nolte-'t Hoen ENM
Author Correction: The Pel polysaccharide is predominantly composed of a dimeric repeat of α-1,4 linked galactosamine and N-acetylgalactosamine.
1. Commun Biol - published June 2, 2022
2. Le Mauff F, Razvi E, Reichhardt C, Sivarajah P, Parsek MR, Howell PL, Sheppard DC
Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct.
1. J Virol - published June 2, 2022
2. Jia H, Zhong Y, Peng C, Gong P
Structural Basis for Fluorescence Activation by Pepper RNA.
1. ACS Chem Biol - published June 2, 2022
2. Rees HC, Gogacz W, Li NS, Koirala D, Piccirilli JA
Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency.
1. Nat Commun - published June 2, 2022
2. Prew MS, Camara CM, Botzanowski T, Moroco JA, Bloch NB, Levy HR, Seo HS, Dhe-Paganon S, Bird GH, Herce HD, Gygi MA, Escudero S, Wales TE, Engen JR, Walensky LD
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition.
1. Nat Immunol - published June 2, 2022
2. Ming Q, Celias DP, Wu C, Cole AR, Singh S, Mason C, Dong S, Tran TH, Amarasinghe GK, Ruffell B, Luca VC
¹⁹F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA-Guanine Transglycosylase.
1. ACS Chem Biol - published June 2, 2022
2. Nguyen A, Gemmecker G, Softley CA, Movsisyan LD, Pfaffeneder T, Heine A, Reuter K, Diederich F, Sattler M, Klebe G
Degradation of GSPT1 causes TP53-independent cell death in leukemia whilst sparing normal hematopoietic stem cells.
1. J Clin Invest - published June 2, 2022
2. Sellar RS, Sperling AS, Słabicki M, Gasser JA, McConkey ME, Donovan KA, Mageed N, Adams DN, Zou C, Miller PG, Dutta RK, Boettcher S, Lin AE, Sandoval BE, Quevedo Barrios VA, Shkolnik V, Koeppel J, Henderson EK, Fink EC, Yang L, Chan AK, Pokharel SP, Bergstrom EJ, Burt R, Udeshi ND, Carr SA, Fischer ES, Chen CW, Ebert BL
Antiviral treatment with fluoxetine for rituximab-associated chronic echovirus 13 meningoencephalitis and myofasciitis.
1. Eur J Neurol - published June 2, 2022
2. Vermeersch G, Laenen L, Lens G, van der Elst KCM, Thal DR, Jentjens S, Demaerel P, Van Nieuwenhuyse T, Wollants E, Boeckx N, Verhaert N, Dubois B, Kuppeveld FJM, Woei-A-Jin FJSHS
Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains.
1. EMBO Rep - published June 2, 2022
2. Dao TP, Yang Y, Presti MF, Cosgrove MS, Hopkins JB, Ma W, Loh SN, Castañeda CA
Discovering molecular features of intrinsically disordered regions by using evolution for contrastive learning.
1. PLoS Comput Biol - published June 2, 2022
2. Lu AX, Lu AX, Pritišanac I, Zarin T, Forman-Kay JD, Moses AM
A surface pocket in the cytoplasmic domain of the herpes simplex virus fusogen gB controls membrane fusion.
1. PLoS Pathog - published June 2, 2022
2. Pataki Z, Sanders EK, Heldwein EE
Strain Variation in Clostridioides difficile Cytotoxicity Associated with Genomic Variation at Both Pathogenic and Nonpathogenic Loci.
1. mSphere - published June 2, 2022
2. Saund K, Pirani A, Lacy DB, Hanna PC, Snitkin E
Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response.
1. J Med Chem - published June 2, 2022
2. Yang MH, Russell JL, Mifune Y, Wang Y, Shi H, Moresco EMY, Siegwart DJ, Beutler B, Boger DL
Phenylsulfamoyl Benzoic Acid Inhibitor of ERAP2 with a Novel Mode of Inhibition.
1. ACS Chem Biol - published June 2, 2022
2. Arya R, Maben Z, Rane D, Ali A, Stern LJ
A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
1. Nature - published June 2, 2022
2. Feng P, Wu X, Erramilli SK, Paulo JA, Knejski P, Gygi SP, Kossiakoff AA, Rapoport TA
Crystal Structure of Trypanosoma cruzi Heme Peroxidase and Characterisation of its Substrate Specificity and Compound I Intermediate.
1. J Biol Chem - published June 2, 2022
2. Freeman SL, Skafar V, Kwon H, Fielding AJ, Moody PCE, Martínez A, Issoglio F, Inchausti L, Smircich P, Zeida A, Piacenza L, Radi R, Raven EL
Rapid detection of an Ebola biomarker with optical microring resonators.
1. Cell Rep Methods - published June 2, 2022
2. Qavi AJ, Meserve K, Aman MJ, Vu H, Zeitlin L, Dye JM, Froude JW, Leung DW, Yang L, Holtsberg FW, Bailey RC, Amarasinghe GK
Development of a Theory-Based, Culturally Appropriate Message Library for Use in Interventions to Promote COVID-19 Vaccination among African Americans: Formative Research.
1. JMIR Form Res - published June 2, 2022
2. Cunningham-Erves J, Brandt HM, Sanderson M, Clarkson K, Lee O, Schlundt D, Bonnet K, Davis J
Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
1. Mol Cell - published June 2, 2022
2. Rouleau-Turcotte É, Krastev DB, Pettitt SJ, Lord CJ, Pascal JM
Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability.
1. Int J Mol Sci - published June 2, 2022
2. Kopra K, Valtonen S, Mahran R, Kapp JN, Hassan N, Gillette W, Dennis B, Li L, Westover KD, Plückthun A, Härmä H
Human PARP1 Facilitates Transcription through a Nucleosome and Histone Displacement by Pol II In Vitro.
1. Int J Mol Sci - published June 2, 2022
2. Kotova EY, Hsieh FK, Chang HW, Maluchenko NV, Langelier MF, Pascal JM, Luse DS, Feofanov AV, Studitsky VM
Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2.
1. Cell Rep - published June 2, 2022
2. Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Khalid MM, Taha TY, Tabata T, Hayashi JM, Soveg FW, Carlson-Stevermer J, Gupta M, Zhang MY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, Krogan N, Fujimori DG, Ott M
Optimized AAV Vectors for TMC1 Gene Therapy in a Humanized Mouse Model of DFNB7/11.
1. Biomolecules - published June 2, 2022
2. Marcovich I, Baer NK, Shubina-Oleinik O, Eclov R, Beard CW, Holt JR
Structure and conformational dynamics of Clostridioides difficile toxin A.
1. Life Sci Alliance - published June 1, 2022
2. Chen B, Basak S, Chen P, Zhang C, Perry K, Tian S, Yu C, Dong M, Huang L, Bowen ME, Jin R
Retinal artery and vein occlusion in calciphylaxis.
1. Am J Ophthalmol Case Rep - published June 1, 2022
2. Naranjo A, Rayess N, Ryan E, Iv M, Mahajan VB
High-yield overproduction and purification of human aquaporins from Pichia pastoris.
1. STAR Protoc - published June 1, 2022
2. Al-Jubair T, Steffen JH, Missel JW, Kitchen P, Salman MM, Bill RM, Gourdon P, Törnroth-Horsefield S
Characterization of human aquaporin protein-protein interactions using microscale thermophoresis (MST).
1. STAR Protoc - published June 1, 2022
2. Al-Jubair T, Steffen JH, Missel JW, Kitchen P, Salman MM, Bill RM, Gourdon P, Törnroth-Horsefield S
Assessing water permeability of aquaporins in a proteoliposome-based stopped-flow setup.
1. STAR Protoc - published June 1, 2022
2. Steffen JH, Missel JW, Al-Jubair T, Kitchen P, Salman MM, Bill RM, Törnroth-Horsefield S, Gourdon P
Microfluidic platform for spatially segregated experimental evolution studies with E. coli.
1. STAR Protoc - published June 1, 2022
2. Seo S, Prabhakar RG, Disney-McKeethen S, Song X, Shamoo Y
Multimodal imaging reveals retinoschisis masquerading as retinal detachment in patients with choroideremia.
1. Am J Ophthalmol Case Rep - published June 1, 2022
2. Greig LC, Gutierrez KG, Oh JK, Levi SR, Korot E, Tsang SH, Mahajan VB
Proteomic analysis of autoimmune retinopathy implicates NrCAM as a potential biomarker.
1. Ophthalmol Sci - published June 1, 2022
2. Al-Moujahed A, Velez G, Vu JT, Lima de Carvalho JR, Levi SR, Bassuk AG, Sepah YJ, Tsang SH, Mahajan VB
Real-time cell analysis: A high-throughput approach for testing SARS-CoV-2 antibody neutralization and escape.
1. STAR Protoc - published June 1, 2022
2. Suryadevara N, Gilchuk P, Zost SJ, Mittal N, Zhao LL, Crowe JE Jr, Carnahan RH
Using fluorescence anisotropy to monitor chaperone dispersal of RNA-binding protein condensates.
1. STAR Protoc - published June 1, 2022
2. Yoo H, Drummond DA
xia2.multiplex: a multi-crystal data-analysis pipeline.
1. Acta Crystallogr D Struct Biol - published June 1, 2022
2. Gildea RJ, Beilsten-Edmands J, Axford D, Horrell S, Aller P, Sandy J, Sanchez-Weatherby J, Owen CD, Lukacik P, Strain-Damerell C, Owen RL, Walsh MA, Winter G
Pentameric assembly of the Kv2.1 tetramerization domain.
1. Acta Crystallogr D Struct Biol - published June 1, 2022
2. Xu Z, Khan S, Schnicker NJ, Baker S
BacPROTACs mediate targeted protein degradation in bacteria.
1. Cell - published June 1, 2022
2. Morreale FE, Kleine S, Leodolter J, Junker S, Hoi DM, Ovchinnikov S, Okun A, Kley J, Kurzbauer R, Junk L, Guha S, Podlesainski D, Kazmaier U, Boehmelt G, Weinstabl H, Rumpel K, Schmiedel VM, Hartl M, Haselbach D, Meinhart A, Kaiser M, Clausen T
Bacterial H-NS contacts DNA at the same irregularly spaced sites in both bridged and hemi-sequestered linear filaments.
1. iScience - published June 1, 2022
2. Shen BA, Hustmyer CM, Roston D, Wolfe MB, Landick R
Architecture of the linker-scaffold in the nuclear pore.
1. Science - published June 1, 2022
2. Petrovic S, Samanta D, Perriches T, Bley CJ, Thierbach K, Brown B, Nie S, Mobbs GW, Stevens TA, Liu X, Tomaleri GP, Schaus L, Hoelz A
Solving the nuclear pore puzzle.
1. Science - published June 1, 2022
2. Schwartz TU
Bacillary Layer Detachment after Photodynamic Therapy.
1. Ophthalmol Retina - published June 1, 2022
2. Mishra K, Mahajan VB
Architecture of the cytoplasmic face of the nuclear pore.
1. Science - published June 1, 2022
2. Bley CJ, Nie S, Mobbs GW, Petrovic S, Gres AT, Liu X, Mukherjee S, Harvey S, Huber FM, Lin DH, Brown B, Tang AW, Rundlet EJ, Correia AR, Chen S, Regmi SG, Stevens TA, Jette CA, Dasso M, Patke A, Palazzo AF, Kossiakoff AA, Hoelz A
Property-Driven Development of Passively Permeable Macrocyclic Scaffolds using Heterocycles.
1. Angew Chem Int Ed Engl - published June 1, 2022
2. Saunders GJ, Yudin AK
Development of OPLS-AA/M Parameters for Simulations of G Protein-Coupled Receptors and Other Membrane Proteins.
1. J Chem Theory Comput - published June 1, 2022
2. Robertson MJ, Skiniotis G
An active learning framework improves tumor variant interpretation.
1. Cancer Res - published June 1, 2022
2. Blee AM, Li B, Pecen T, Meiler J, Nagel ZD, Capra JA, Chazin WJ
Characterization of SARS-CoV-2 replication complex elongation and proofreading activity.
1. Sci Rep - published June 1, 2022
2. Jones AN, Mourão A, Czarna A, Matsuda A, Fino R, Pyrc K, Sattler M, Popowicz GM
Recommendations on qPCR/ddPCR Assay Validation by GCC.
1. Bioanalysis - published June 1, 2022
2. Wissel M, Poirier M, Satterwhite C, Lin J, Islam R, Zimmer J, Khadang A, Zemo J, Lester T, Fjording M, Hays A, Hughes N, Garofolo F, Guilbaud R, Groeber E, Renfrew H, Colletti K, Yu M, Lin J, Fang X, Shah S, Garofolo W, Kar S, Hayes R, Pirro J, Kane C, Luna M, Xu A, Cape S, O'Dell M, Wheller R, Ritzen H, Vance J, Farley E, Matys K, Tabler E, Mylott W, Yuan M, Karnik S, Voelker T, DuBey I, Williard C, Shi J, Yamashita J
Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells.
1. Antimicrob Agents Chemother - published June 1, 2022
2. Icho S, Rujas E, Muthuraman K, Tam J, Liang H, Landreth S, Liao M, Falzarano D, Julien JP, Melnyk RA
Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4.
1. PLoS Pathog - published June 1, 2022
2. Welles HC, King HAD, Nettey L, Cavett N, Gorman J, Zhou T, Tsybovsky Y, Du R, Song K, Nguyen R, Ambrozak D, Ransier A, Schramm CA, Doria-Rose NA, Swanstrom AE, Hoxie JA, LaBranche C, Montefiori DC, Douek DC, Kwong PD, Mascola JR, Roederer M, Mason RD
An effective workshop on "How to be an Effective Mentor for Underrepresented STEM Trainees".
1. Pathog Dis - published June 1, 2022
2. Marshall AG, Vue Z, Palavicino-Maggio CB, Neikirk K, Beasley HK, Garza-Lopez E, Murray SA, Martinez D, Crabtree A, Conley ZC, Vang L, Davis JS, Powell-Roach KL, Campbell S, Brady LJ, Dal AB, Shao B, Alexander S, Vang N, Vue N, Vue M, Shuler HD, Spencer EC, Morton DJ, Hinton A
Liquid Phase Partitioning in Virus Replication: Observations and Opportunities.
1. Annu Rev Virol - published June 1, 2022
2. Wu C, Holehouse AS, Leung DW, Amarasinghe GK, Dutch RE
Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation.
1. Mol Cell - published June 1, 2022
2. Huppertz I, Perez-Perri JI, Mantas P, Sekaran T, Schwarzl T, Russo F, Ferring-Appel D, Koskova Z, Dimitrova-Paternoga L, Kafkia E, Hennig J, Neveu PA, Patil K, Hentze MW
O-GlcNAc transferase maintains metabolic homeostasis in response to CDK9 inhibition.
1. Glycobiology - published June 1, 2022
2. Gondane A, Poulose N, Walker S, Mills IG, Itkonen HM
Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta.
1. Nat Struct Mol Biol - published June 1, 2022
2. Walter JD, Remm S, Seeger MA
Direct tracking of reverse-transcriptase speed and template sensitivity: implications for sequencing and analysis of long RNA molecules.
1. Nucleic Acids Res - published June 1, 2022
2. Guo LT, Olson S, Patel S, Graveley BR, Pyle AM
Reaction Mechanism and Three-Dimensional Structure of GDP-d-glycero-α-d-manno-heptose 4,6-Dehydratase from Campylobacter jejuni.
1. Biochemistry - published June 1, 2022
2. Xiang DF, Thoden JB, Ghosh MK, Holden HM, Raushel FM
Ned Seeman and the prediction of amino acid-base pair motifs mediating sequence-specific recognition of nucleic acid duplexes by proteins.
1. Biophys J - published June 1, 2022
2. Egli M, Zhang S
Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine.
1. Nat Commun - published June 1, 2022
2. Kramer KJ, Wilfong EM, Voss K, Barone SM, Shiakolas AR, Raju N, Roe CE, Suryadevara N, Walker LM, Wall SC, Paulo A, Schaefer S, Dahunsi D, Westlake CS, Crowe JE Jr, Carnahan RH, Rathmell JC, Bonami RH, Georgiev IS, Irish JM
The Role of Mentoring in Promoting Diversity Equity and Inclusion in STEM Education and Research.
1. Pathog Dis - published June 1, 2022
2. Marshall AG, Vue Z, Palavicino-Maggio CB, Neikirk K, Beasley HK, Garza-Lopez E, Murray SA, Martinez D, Crabtree A, Conley ZC, Vang L, Davis JS, Powell-Roach KL, Campbell S, Brady LJ, Dal AB, Shao B, Alexander S, Vang N, Vue N, Vue M, Shuler HD, Spencer EC, Morton DJ, Hinton A
Learning from HBCUs: How to produce Black professionals in STEMM.
1. Cell - published June 1, 2022
2. Shuler HD, Spencer EC, Davis JS, Damo S, Shakespeare TI, Murray SA, Lee DL, Hinton A Jr
Human rs75776403 polymorphism links differential phenotypic and clinical outcomes to a CLEC18A p.T151M-driven multiomics.
1. J Biomed Sci - published June 1, 2022
2. Hsu YW, Wong HS, Huang WC, Yeh YH, Hsiao CD, Chang WC, Hsieh SL
Comparing the structural dynamics of the human KCNE3 in reconstituted micelle and lipid bilayered vesicle environments.
1. Biochim Biophys Acta Biomembr - published June 1, 2022
2. Campbell C, Faleel FDM, Scheyer MW, Haralu S, Williams PL, Carbo WD, Wilson-Taylor AS, Patel NH, Sanders CR, Lorigan GA, Sahu ID
Towards Generalizable Predictions for the Effects of Mutations on G-Protein Coupled Receptor Expression.
1. Biophys J - published June 1, 2022
2. Kuntz CP, Woods H, McKee AG, Zelt NB, Mendenhall JL, Meiler J, Schlebach JP
LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions.
1. Mol Neurodegener - published June 1, 2022
2. Zhao P, Xu Y, Jiang LL, Fan X, Ku Z, Li L, Liu X, Deng M, Arase H, Zhu JJ, Huang TY, Zhao Y, Zhang C, Xu H, Tong Q, Zhang N, An Z
Designed Ankyrin Repeat Proteins as a tool box for analyzing p63.
1. Cell Death Differ - published June 1, 2022
2. Strubel A, Münick P, Chaikuad A, Dreier B, Schaefer J, Gebel J, Osterburg C, Tuppi M, Schäfer B, Knapp S, Plückthun A, Dötsch V
Photoaffinity labeling approaches to elucidate lipid-protein interactions.
1. Curr Opin Chem Biol - published June 1, 2022
2. Yu W, Baskin JM
Cobalamin-Dependent Radical S-Adenosylmethionine Enzymes: Capitalizing on Old Motifs for New Functions.
1. ACS Bio Med Chem Au - published June 1, 2022
2. Bridwell-Rabb J, Li B, Drennan CL
Antibody-based redirection of universal Fabrack-CAR T cells selectively kill antigen bearing tumor cells.
1. J Immunother Cancer - published June 1, 2022
2. Kuo YC, Kuo CF, Jenkins K, Hung AF, Chang WC, Park M, Aguilar B, Starr R, Hibbard J, Brown C, Williams JC
Corrigendum to "Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors" [Bioorg. Med. Chem. Lett. 60 (2022) 128549].
1. Bioorg Med Chem Lett - published June 1, 2022
2. Ma B, Metrick CM, Gu C, Hoemberger M, Bajrami B, Bame E, Huang J, Mingueneau M, Murugan P, Nevalainen M, Santoro JC, Tang H, Wang T, Hopkins BT
Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry.
1. Structure - published June 1, 2022
2. Dickinson MS, Miyazawa T, McCool RS, Keatinge-Clay AT
Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors.
1. Biomolecules - published June 1, 2022
2. van Beelen ESA, van der Valk WH, Verhagen TO, de Groot JCMJ, Madison MA, Shadmanfar W, Hensen EF, Jansen JC, van Benthem PPG, Holt JR, Locher H
An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma.
1. Mol Cell - published June 1, 2022
2. Zhou J, Simon JM, Liao C, Zhang C, Hu L, Zurlo G, Liu X, Fan C, Hepperla A, Jia L, Tcheuyap VT, Zhong H, Elias R, Ye J, Henne WM, Kapur P, Nijhawan D, Brugarolas J, Zhang Q