Member Publications

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127 Member Publications for February 2022

Effective Communication About Pregnancy, Birth, Lactation, Breastfeeding and Newborn Care: The Importance of Sexed Language.
1. Front Glob Womens Health - published February 28, 2022
2. Gribble KD, Bewley S, Bartick MC, Mathisen R, Walker S, Gamble J, Bergman NJ, Gupta A, Hocking JJ, Dahlen HG
ATP Synthase K⁺- and H⁺-fluxes Drive ATP Synthesis and Enable Mitochondrial K⁺-"Uniporter" Function: II. Ion and ATP Synthase Flux Regulation.
1. Function (Oxf) - published February 21, 2022
2. Juhaszova M, Kobrinsky E, Zorov DB, Nuss HB, Yaniv Y, Fishbein KW, de Cabo R, Montoliu L, Gabelli SB, Aon MA, Cortassa S, Sollott SJ
Recent advances in the structural biology of encapsulin bacterial nanocompartments.
1. J Struct Biol X - published February 11, 2022
2. Wiryaman T, Toor N
Uncoupling Molecular Testing for SARS-CoV-2 From International Supply Chains.
1. Front Public Health - published February 10, 2022
2. Stanton JL, O'Brien R, Hall RJ, Chernyavtseva A, Ha HJ, Jelley L, Mace PD, Klenov A, Treece JM, Fraser JD, Clow F, Clarke L, Su Y, Kurup HM, Filichev VV, Rolleston W, Law L, Rendle PM, Harris LD, Wood JM, Scully TW, Ussher JE, Grant J, Hore TA, Moser TV, Harfoot R, Lawley B, Quiñones-Mateu ME, Collins P, Blaikie R
Ribonucleotide reductase, a novel drug target for gonorrhea.
1. Elife - published February 9, 2022
2. Narasimhan J, Letinski S, Jung SP, Gerasyuto A, Wang J, Arnold M, Chen G, Hedrick J, Dumble M, Ravichandran K, Levitz T, Chang C, Drennan CL, Stubbe J, Karp G, Branstrom A
Universal platform for the generation of thermostabilized GPCRs that crystallize in LCP.
1. Nat Protoc - published February 9, 2022
2. Schöppe J, Ehrenmann J, Waltenspühl Y, Plückthun A
Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias.
1. Nature - published February 9, 2022
2. Hu C, Leche CA 2nd, Kiyatkin A, Yu Z, Stayrook SE, Ferguson KM, Lemmon MA
Even old foes can learn sweet new tricks.
1. Cell Host Microbe - published February 9, 2022
2. Crowe JE Jr, Carnahan RH
The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature.
1. bioRxiv - published February 9, 2022
2. Correy GJ, Kneller DW, Phillips G, Pant S, Russi S, Cohen AE, Meigs G, Holton JM, Gahbauer S, Thompson MC, Ashworth A, Coates L, Kovalevsky A, Meilleur F, Fraser JS
Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells.
1. Proc Natl Acad Sci U S A - published February 8, 2022
2. Amraei R, Xia C, Olejnik J, White MR, Napoleon MA, Lotfollahzadeh S, Hauser BM, Schmidt AG, Chitalia V, Mühlberger E, Costello CE, Rahimi N
Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly.
1. Proc Natl Acad Sci U S A - published February 8, 2022
2. de Vries T, Martelly W, Campagne S, Sabath K, Sarnowski CP, Wong J, Leitner A, Jonas S, Sharma S, Allain FH
High-speed atomic force microscopy reveals a three-state elevator mechanism in the citrate transporter CitS.
1. Proc Natl Acad Sci U S A - published February 8, 2022
2. Maity S, Trinco G, Buzón P, Anshari ZR, Kodera N, Ngo KX, Ando T, Slotboom DJ, Roos WH
A protease-mediated switch regulates the growth of magnetosome organelles in Magnetospirillum magneticum.
1. Proc Natl Acad Sci U S A - published February 8, 2022
2. Wan J, Browne PJ, Hershey DM, Montabana E, Iavarone AT, Downing KH, Komeili A
Electrostatic influence on IL-1 transport through the GSDMD pore.
1. Proc Natl Acad Sci U S A - published February 8, 2022
2. Xie WJ, Xia S, Warshel A, Wu H
Effects of the Chinese Herb Medicine Formula "She-Xiang-Yu-Hong" Ointment on Wound Healing Promotion in Diabetic Mice.
1. Evid Based Complement Alternat Med - published February 8, 2022
2. Li Q, Liu X, Yang S, Li C, Jin W, Hou W
Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
1. Nat Commun - published February 8, 2022
2. Simon B, Lou HJ, Huet-Calderwood C, Shi G, Boggon TJ, Turk BE, Calderwood DA
An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking.
1. Commun Biol - published February 8, 2022
2. Dey D, Singh S, Khan S, Martin M, Schnicker NJ, Gakhar L, Pierce BG, Hasan SS
Publisher Correction: The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites.
1. Nat Microbiol - published February 8, 2022
2. Campelo Morillo RA, Tong X, Xie W, Abel S, Orchard LM, Daher W, Patel DJ, Llinás M, Le Roch KG, Kafsack BFC
Solution structure and dynamics of the mitochondrial-targeted GTPase-activating protein (GAP) VopE by an integrated NMR/SAXS approach.
1. Protein Sci - published February 8, 2022
2. Smith KP, Lee W, Tonelli M, Lee Y, Light SH, Cornilescu G, Chakravarthy S
Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer.
1. Nat Commun - published February 8, 2022
2. Yang Z, Dam KA, Bridges MD, Hoffmann MAG, DeLaitsch AT, Gristick HB, Escolano A, Gautam R, Martin MA, Nussenzweig MC, Hubbell WL, Bjorkman PJ
Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
1. Nat Commun - published February 8, 2022
2. Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY
Chaperones directly and efficiently disperse stress-triggered biomolecular condensates.
1. Mol Cell - published February 8, 2022
2. Yoo H, Bard JAM, Pilipenko EV, Drummond DA
A Hydrophilic Microenvironment in the Substrate-Translocating Groove of the YidC Membrane Insertase is Essential for Enzyme Function.
1. J Biol Chem - published February 8, 2022
2. Chen Y, Sotomayor M, Capponi S, Hariharan B, Sahu ID, Haase M, Lorigan GA, Kuhn A, White SH, Dalbey RE
Integration of software tools for integrative modeling of biomolecular systems.
1. J Struct Biol - published February 8, 2022
2. Hancock M, Peulen TO, Webb B, Poon B, Fraser JS, Adams P, Sali A
Structures and nucleic acid-binding preferences of the eukaryotic ARID domain.
1. Biol Chem - published February 7, 2022
2. Korn SM, Schlundt A
Conformational switches that control the TEC kinase - PLCγ signaling axis.
1. J Struct Biol X - published February 7, 2022
2. Lowe J, Joseph RE, Andreotti AH
Author Correction: Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.
1. Nature - published February 7, 2022
2. Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N
Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling.
1. Nat Commun - published February 7, 2022
2. Maimets M, Pedersen MT, Guiu J, Dreier J, Thodberg M, Antoku Y, Schweiger PJ, Rib L, Bressan RB, Miao Y, Garcia KC, Sandelin A, Serup P, Jensen KB
Inflammasome activation and pyroptosis via a lipid-regulated SIRT1-p53-ASC axis in macrophages from male mice and humans.
1. Endocrinology - published February 5, 2022
2. Huang Y, Yong P, Dickey D, Vora SM, Wu H, Bernlohr DA
pHBMT1, a BAHD-family monolignol acyltransferase, mediates lignin acylation in poplar.
1. Plant Physiol - published February 4, 2022
2. de Vries L, MacKay HA, Smith RA, Mottiar Y, Karlen SD, Unda F, Muirragui E, Bingman C, Vander Meulen K, Beebe ET, Fox BG, Ralph J, Mansfield SD
Gating choreography and mechanism of the human proton-activated chloride channel ASOR.
1. Sci Adv - published February 4, 2022
2. Wang C, Polovitskaya MM, Delgado BD, Jentsch TJ, Long SB
The protein-folding problem: Not yet solved.
1. Science - published February 4, 2022
2. Moore PB, Hendrickson WA, Henderson R, Brunger AT
Dynamics of the Histone Acetyltransferase Lysine-Rich Loop in the Catalytic Core of the CREB-Binding Protein.
1. J Chem Inf Model - published February 4, 2022
2. Salutari I, Caflisch A
Human Antibodies for Viral Infections.
1. Annu Rev Immunol - published February 3, 2022
2. Crowe JE Jr
Structural features determining the vitamin K epoxide reduction activity in the VKOR family of membrane oxidoreductases.
1. FEBS J - published February 3, 2022
2. Shen G, Li C, Cao Q, Megta AK, Li S, Gao M, Liu H, Shen Y, Chen Y, Yu H, Li S, Li W
WIN site inhibition disrupts a subset of WDR5 function.
1. Sci Rep - published February 3, 2022
2. Siladi AJ, Wang J, Florian AC, Thomas LR, Creighton JH, Matlock BK, Flaherty DK, Lorey SL, Howard GC, Fesik SW, Weissmiller AM, Liu Q, Tansey WP
A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination.
1. Nat Med - published February 3, 2022
2. Andrews SF, Raab JE, Gorman J, Gillespie RA, Cheung CSF, Rawi R, Cominsky LY, Boyington JC, Creanga A, Shen CH, Harris DR, Olia AS, Nazzari AF, Zhou T, Houser KV, Chen GL, Mascola JR, Graham BS, Kanekiyo M, Ledgerwood JE, Kwong PD, McDermott AB
Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis.
1. Nat Commun - published February 3, 2022
2. Yan Y, Zhou B, Qian C, Vasquez A, Kamra M, Chatterjee A, Lee YJ, Yuan X, Ellis L, Di Vizio D, Posadas EM, Kyprianou N, Knudsen BS, Shah K, Murali R, Gertych A, You S, Freeman MR, Yang W
A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in cynomolgus macaques.
1. Med (N Y) - published February 3, 2022
2. Cobb RR, Nkolola J, Gilchuk P, Chandrashekar A, Yu J, House RV, Earnhart CG, Dorsey NM, Hopkins SA, Snow DM, Chen RE, VanBlargan LA, Hechenblaickner M, Hoppe B, Collins L, Tomic MT, Nonet GH, Hackett K, Slaughter JC, Lewis M, Andersen H, Cook A, Diamond MS, Carnahan RH, Barouch DH, Crowe JE Jr
Identification and Characterization of a Set of Monocot BAHD Monolignol Transferases.
1. Plant Physiol - published February 3, 2022
2. Smith RA, Beebe ET, Bingman CA, Vander Meulen K, Eugene A, Steiner AJ, Karlen SD, Ralph J, Fox BG
Cryo-EM Structure of a Possum Enterovirus.
1. Viruses - published February 3, 2022
2. Wang I, Gupta SK, Ems G, Jayawardena N, Strauss M, Bostina M
Regulation by metal ions and the ADMIDAS of integrin α5β1 conformational states and intrinsic affinities.
1. Mol Biol Cell - published February 2, 2022
2. Anderson JM, Li J, Springer TA
Developmental roles and molecular mechanisms of Asterix/GTSF1.
1. Wiley Interdiscip Rev RNA - published February 2, 2022
2. Ipsaro JJ, Joshua-Tor L
CBASS phage defense and evolution of antiviral nucleotide signaling.
1. Curr Opin Immunol - published February 2, 2022
2. Duncan-Lowey B, Kranzusch PJ
Tall tails: cryo-electron microscopy of phage tail DNA ejection conduits.
1. Biochem Soc Trans - published February 2, 2022
2. Hardy JM, Dunstan RA, Lithgow T, Coulibaly F
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.
1. Cell - published February 2, 2022
2. Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I
Studying membrane proteins with MicroED.
1. Biochem Soc Trans - published February 2, 2022
2. Gallenito MJ, Gonen T
Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression.
1. EMBO Mol Med - published February 2, 2022
2. Yildirim Z, Baboo S, Hamid SM, Dogan AE, Tufanli O, Robichaud S, Emerton C, Diedrich JK, Vatandaslar H, Nikolos F, Gu Y, Iwawaki T, Tarling E, Ouimet M, Nelson DL, Yates JR 3rd, Walter P, Erbay E
Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance.
1. Nucleic Acids Res - published February 2, 2022
2. Chen X, Bradley NP, Lu W, Wahl KL, Zhang M, Yuan H, Hou XF, Eichman BF, Tang GL
Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture.
1. Commun Biol - published February 2, 2022
2. Wang X, Sacramento CQ, Jockusch S, Chaves OA, Tao C, Fintelman-Rodrigues N, Chien M, Temerozo JR, Li X, Kumar S, Xie W, Patel DJ, Meyer C, Garzia A, Tuschl T, Bozza PT, Russo JJ, Souza TML, Ju J
Multiple genetic paths including massive gene amplification allow Mycobacterium tuberculosis to overcome loss of ESX-3 secretion system substrates.
1. Proc Natl Acad Sci U S A - published February 2, 2022
2. Wang L, Asare E, Shetty AC, Sanchez-Tumbaco F, Edwards MR, Saranathan R, Weinrick B, Xu J, Chen B, Bénard A, Dougan G, Leung DW, Amarasinghe GK, Chan J, Basler CF, Jacobs WR Jr, Tufariello JM
Development of High affinity Nanobodies Specific for Na_V1.4 and Na_V1.5 Voltage-Gated Sodium Channel Isoforms.
1. J Biol Chem - published February 2, 2022
2. Srinivasan L, Alzogaray V, Selvakumar D, Nathan S, Yoder JB, Wright KM, Klinke S, Nwafor JN, Labanda MS, Goldbaum FA, Schön A, Freire E, Tomaselli GF, Amzel LM, Ben-Johny M, Gabelli SB
Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting.
1. Science - published February 2, 2022
2. Jomaa A, Gamerdinger M, Hsieh HH, Wallisch A, Chandrasekaran V, Ulusoy Z, Scaiola A, Hegde RS, Shan SO, Ban N, Deuerling E
Pre-Transition State and Apo Structures of the Filament-Forming Enzyme SgrAI Elucidate Mechanisms of Activation and Substrate Specificity.
1. J Biol Chem - published February 2, 2022
2. Shan Z, Ghadirian N, Lyumkis D, Horton NC
Nuclear SOD1 in Growth Control, Oxidative Stress Response, Amyotrophic Lateral Sclerosis, and Cancer.
1. Antioxidants (Basel) - published February 2, 2022
2. Xu J, Su X, Burley SK, Zheng XFS
Protein Dynamics to Define and Refine Disordered Protein Ensembles.
1. J Phys Chem B - published February 2, 2022
2. Naullage PM, Haghighatlari M, Namini A, Teixeira JMC, Li J, Zhang O, Gradinaru CC, Forman-Kay JD, Head-Gordon T
Water Specific MRI T1 Mapping for Evaluating Liver Inflammation Activity Grades in Rats With Methionine-Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease.
1. J Magn Reson Imaging - published February 2, 2022
2. Wan Q, Peng H, Lyu J, Liu F, Cheng C, Qiao Y, Deng J, Zheng H, Wang Y, Zou C, Liu X
Challenges and Advantages of Accounting for Backbone Flexibility in Prediction of Protein-Protein Complexes.
1. J Chem Theory Comput - published February 2, 2022
2. Faruk NF, Peng X, Freed KF, Roux B, Sosnick TR
Vault RNA1-1 riboregulates the autophagic function of p62 by binding to K7/R21 that are critical for p62 oligomerisation.
1. RNA - published February 2, 2022
2. Büscher M, Horos R, Huppertz I, Haubrich K, Dobrev N, Baudin F, Hennig J, Hentze MW
Seipin forms a flexible cage at lipid droplet formation sites.
1. Nat Struct Mol Biol - published February 2, 2022
2. Arlt H, Sui X, Folger B, Adams C, Chen X, Remme R, Hamprecht FA, DiMaio F, Liao M, Goodman JM, Farese RV Jr, Walther TC
Plasticity in ligand recognition at somatostatin receptors.
1. Nat Struct Mol Biol - published February 2, 2022
2. Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G
A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
1. Nat Commun - published February 2, 2022
2. Schmidt JM, Yang R, Kumar A, Hunker O, Seebacher J, Bleichert F
Investigation of Cas9 antibodies in the human eye.
1. Nat Commun - published February 2, 2022
2. Toral MA, Charlesworth CT, Ng B, Chemudupati T, Homma S, Nakauchi H, Bassuk AG, Porteus MH, Mahajan VB
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity.
1. Mol Cell - published February 2, 2022
2. Tsuchida CA, Zhang S, Doost MS, Zhao Y, Wang J, O'Brien E, Fang H, Li CP, Li D, Hai ZY, Chuck J, Brötzmann J, Vartoumian A, Burstein D, Chen XW, Nogales E, Doudna JA, Liu JG
Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex.
1. Dev Cell - published February 2, 2022
2. Huang P, Wierbowski BM, Lian T, Chan C, García-Linares S, Jiang J, Salic A
Bispecific antiviral neutralizing antibodies are twice as nice.
1. Nat Immunol - published February 2, 2022
2. Crowe JE Jr
Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract.
1. Kidney Int - published February 2, 2022
2. Münch J, Engesser M, Schönauer R, Hamm JA, Hartig C, Hantmann E, Akay G, Pehlivan D, Mitani T, Akdemir ZC, Tüysüz B, Shirakawa T, Dateki S, Claus LR, van Eerde AM, Genomics England Research Consortium., Smol T, Devisme L, Franquet H, Attié-Bitach T, Wagner T, Bergmann C, Höhn AK, Shril S, Pollack A, Wegner T, Scott A, Paolucci S, Buchan J, Gabriel GC, Posey JE, Lupski JR, Petit F, McCarthy AA, Pazour GJ, Lo CW, Popp B, Halbritter J
Proteolytic pan-RAS cleavage leads to tumor regression in patient-derived pancreatic cancer xenografts.
1. Mol Cancer Ther - published February 2, 2022
2. Vidimar V, Park M, Stubbs CK, Ingram NK, Qiang W, Zhang S, Gursel DB, Melnyk RA, Satchell KJ
Visualizing the gas channel of a monofunctional carbon monoxide dehydrogenase.
1. J Inorg Biochem - published February 2, 2022
2. Biester A, Dementin S, Drennan CL
Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot.
1. RNA - published February 1, 2022
2. Jones CP, Ferré-D'Amaré AR
Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone α.
1. Mol Cell Biol - published February 1, 2022
2. Romartinez-Alonso B, Agostini M, Jones H, McLellan J, Sood DE, Tomkinson N, Marelli F, Gentile I, Visser WE, Schoenmakers E, Fairall L, Privalsky M, Moran C, Persani L, Chatterjee K, Schwabe JWR
Gp29 LysA of mycobacteriophage TM4 can hydrolyze peptidoglycan through an N-acetyl-muramoyl-L-alanine amidase activity.
1. Biochim Biophys Acta Proteins Proteom - published February 1, 2022
2. Urdániz E, Martín M, Payaslián F, Defelipe LA, Dodes M, Martinez M, Alzari PM, Cabrera G, Martí MA, Piuri M
Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.
1. Proc Natl Acad Sci U S A - published February 1, 2022
2. Belsare KD, Wu H, Mondal D, Bond A, Castillo E, Jin J, Jo H, Roush AE, Pilla KB, Sali A, Condello C, DeGrado WF
Rheumatologists have an important role in the management of interstitial lung disease (ILD): a cross-speciality, multi-centre, U.K. perspective.
1. Rheumatology (Oxford) - published February 1, 2022
2. Mehta P, Hoyles RK, Gunawardena H, Gooptu B, Choudhary N, Heightmann MJ, Garthwaite H, Penn H, Datta A, Hamdulay S, Lams B, Agarwal S, Wickremesinghe M, Jenkins G, Porter JC, Denton CP
Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei.
1. Acta Crystallogr F Struct Biol Commun - published February 1, 2022
2. Beard DK, Subramanian S, Abendroth J, Dranow DM, Edwards TE, Myler PJ, Asojo OA
Crystal structure of a short-chain dehydrogenase/reductase from Burkholderia phymatum in complex with NAD.
1. Acta Crystallogr F Struct Biol Commun - published February 1, 2022
2. Alenazi J, Mayclin S, Subramanian S, Myler PJ, Asojo OA
Crystal structure of a hypothetical protein from Giardia lamblia.
1. Acta Crystallogr F Struct Biol Commun - published February 1, 2022
2. Beard DK, Bristol S, Cosby K, Davis A, Manning C, Perry L, Snapp L, Toy A, Wheeler K, Young J, Staker B, Arakaki TL, Abendroth J, Subrahamanian S, Edwards TE, Myler PJ, Asojo OA
Nucleation of glucose isomerase protein crystals in a nonclassical disguise: The role of crystalline precursors.
1. Proc Natl Acad Sci U S A - published February 1, 2022
2. Van Driessche AES, Ling WL, Schoehn G, Sleutel M
Acylated and alkylated benzo(crown-ethers) form ion-dependent ion channels in biological membranes.
1. Biophys J - published February 1, 2022
2. Carrasquel-Ursulaez W, Dehghany M, Jones CL, Idikuda V, Lu B, Schomaker JM, Chanda B
Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P₂ and rapamycin.
1. Proc Natl Acad Sci U S A - published February 1, 2022
2. Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y
Hedgehog pathway modulation by glypican 3-conjugated heparan sulfate.
1. J Cell Sci - published February 1, 2022
2. Liu YC, Wierbowski BM, Salic A
Bivalent recognition of fatty acyl-CoA by a human integral membrane palmitoyltransferase.
1. Proc Natl Acad Sci U S A - published February 1, 2022
2. Lee CJ, Stix R, Rana MS, Shikwana F, Murphy RE, Ghirlando R, Faraldo-Gómez JD, Banerjee A
Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
1. Nat Commun - published February 1, 2022
2. Gunasekar SK, Xie L, Kumar A, Hong J, Chheda PR, Kang C, Kern DM, My-Ta C, Maurer J, Heebink J, Gerber EE, Grzesik WJ, Elliot-Hudson M, Zhang Y, Key P, Kulkarni CA, Beals JW, Smith GI, Samuel I, Smith JK, Nau P, Imai Y, Sheldon RD, Taylor EB, Lerner DJ, Norris AW, Klein S, Brohawn SG, Kerns R, Sah R
Genetic approaches to improve clorobiocin production in Streptomyces roseochromogenes NRRL 3504.
1. Appl Microbiol Biotechnol - published February 1, 2022
2. Melnyk S, Stepanyshyn A, Yushchuk O, Mandler M, Ostash I, Koshla O, Fedorenko V, Kahne D, Ostash B
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins.
1. Genes Dev - published February 1, 2022
2. Zheng L, Liu J, Niu L, Kamran M, Yang AWH, Jolma A, Dai Q, Hughes TR, Patel DJ, Zhang L, Prasanth SG, Yu Y, Ren A, Lai EC
Extracellular electron transfer increases fermentation in lactic acid bacteria via a hybrid metabolism.
1. Elife - published February 1, 2022
2. Tejedor-Sanz S, Stevens ET, Li S, Finnegan P, Nelson J, Knoesen A, Light SH, Ajo-Franklin CM, Marco ML
METTL16 exerts an m⁶A-independent function to facilitate translation and tumorigenesis.
1. Nat Cell Biol - published February 1, 2022
2. Su R, Dong L, Li Y, Gao M, He PC, Liu W, Wei J, Zhao Z, Gao L, Han L, Deng X, Li C, Prince E, Tan B, Qing Y, Qin X, Shen C, Xue M, Zhou K, Chen Z, Xue J, Li W, Qin H, Wu X, Sun M, Nam Y, Chen CW, Huang W, Horne D, Rosen ST, He C, Chen J
Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth.
1. Nat Metab - published February 1, 2022
2. Zhao JS, Shi S, Qu HY, Keckesova Z, Cao ZJ, Yang LX, Yu X, Feng L, Shi Z, Krakowiak J, Mao RY, Shen YT, Fan YM, Fu TM, Ye C, Xu D, Gao X, You J, Li W, Liang T, Lu Z, Feng YX
Defining molecular glues with a dual-nanobody cannabidiol sensor.
1. Nat Commun - published February 1, 2022
2. Cao S, Kang S, Mao H, Yao J, Gu L, Zheng N
Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer.
1. Nat Commun - published February 1, 2022
2. Launonen IM, Lyytikäinen N, Casado J, Anttila EA, Szabó A, Haltia UM, Jacobson CA, Lin JR, Maliga Z, Howitt BE, Strickland KC, Santagata S, Elias K, D'Andrea AD, Konstantinopoulos PA, Sorger PK, Färkkilä A
A novel HER2-selective kinase inhibitor is effective in HER2 mutant and amplified non-small cell lung cancer.
1. Cancer Res - published February 1, 2022
2. Son J, Jang J, Beyett TS, Eum Y, Haikala HM, Verano A, Lin M, Hatcher JM, Kwiatkowski NP, Eser PÖ, Poitras MJ, Wang S, Xu M, Gokhale PC, Cameron MD, Eck MJ, Gray NS, Janne PA
Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium.
1. Commun Biol - published February 1, 2022
2. Vickovic S, Schapiro D, Carlberg K, Lötstedt B, Larsson L, Hildebrandt F, Korotkova M, Hensvold AH, Catrina AI, Sorger PK, Malmström V, Regev A, Ståhl PL
Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling.
1. Proc Natl Acad Sci U S A - published February 1, 2022
2. Bagchi RA, Robinson EL, Hu T, Cao J, Hong JY, Tharp CA, Qasim H, Gavin KM, Pires da Silva J, Major JL, McConnell BK, Seto E, Lin H, McKinsey TA
Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform.
1. Mol Ther - published February 1, 2022
2. Chevillard C, Amen A, Besson S, Hannani D, Bally I, Dettling V, Gout E, Moreau CJ, Buisson M, Gallet S, Fenel D, Vassal-Stermann E, Schoehn G, Poignard P, Dagher MC, Fender P
Adherence enables Neisseria gonorrhoeae to overcome zinc limitation imposed by nutritional immunity proteins.
1. Infect Immun - published February 1, 2022
2. Ray JC, Smirnov A, Maurakis SA, Harrison SA, Ke E, Chazin WJ, Cornelissen CN, Criss AK
SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy.
1. mBio - published February 1, 2022
2. Yang Z, Han Y, Ding S, Shi W, Zhou T, Finzi A, Kwong PD, Mothes W, Lu M
A gut-derived metabolite alters brain activity and anxiety behaviour in mice.
1. Nature - published February 1, 2022
2. Needham BD, Funabashi M, Adame MD, Wang Z, Boktor JC, Haney J, Wu WL, Rabut C, Ladinsky MS, Hwang SJ, Guo Y, Zhu Q, Griffiths JA, Knight R, Bjorkman PJ, Shapiro MG, Geschwind DH, Holschneider DP, Fischbach MA, Mazmanian SK
Iron-sulfur clusters as inhibitors and catalysts of viral replication.
1. Nat Chem - published February 1, 2022
2. Honarmand Ebrahimi K, Ciofi-Baffoni S, Hagedoorn PL, Nicolet Y, Le Brun NE, Hagen WR, Armstrong FA
Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics.
1. Nat Struct Mol Biol - published February 1, 2022
2. Tsai K, Stojković V, Lee DJ, Young ID, Szal T, Klepacki D, Vázquez-Laslop N, Mankin AS, Fraser JS, Fujimori DG
Structural effects of m6A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1.
1. Nucleic Acids Res - published February 1, 2022
2. Jones AN, Tikhaia E, Mourão A, Sattler M
Bat coronaviruses related to SARS-CoV-2 and infectious for human cells.
1. Nature - published February 1, 2022
2. Temmam S, Vongphayloth K, Salazar EB, Munier S, Bonomi M, Regnault B, Douangboubpha B, Karami Y, Chrétien D, Sanamxay D, Xayaphet V, Paphaphanh P, Lacoste V, Somlor S, Lakeomany K, Phommavanh N, Pérot P, Dehan O, Amara F, Donati F, Bigot T, Nilges M, Rey FA, van der Werf S, Brey PT, Eloit M
Termination of Poly-N-acetylglucosamine (PNAG) Polymerization with N-Acetylglucosamine Analogues.
1. ACS Chem Biol - published February 1, 2022
2. Morrison ZA, Eddenden A, Subramanian AS, Howell PL, Nitz M
Cancer patient survival can be parametrized to improve trial precision and reveal time-dependent therapeutic effects.
1. Nat Commun - published February 1, 2022
2. Plana D, Fell G, Alexander BM, Palmer AC, Sorger PK
Rapid Inhibitor Discovery by Exploiting Synthetic Lethality.
1. J Am Chem Soc - published February 1, 2022
2. Muscato JD, Morris HG, Mychack A, Rajagopal M, Baidin V, Hesser AR, Lee W, İnecik K, Wilson LJ, Kraml CM, Meredith TC, Walker S
Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS.
1. EMBO Mol Med - published February 1, 2022
2. Zinngrebe J, Moepps B, Monecke T, Gierschik P, Schlichtig F, Barth TFE, Strauß G, Boldrin E, Posovszky C, Schulz A, Beringer O, Rieser E, Jacobsen EM, Lorenz MR, Schwarz K, Pannicke U, Walczak H, Niessing D, Schuetz C, Fischer-Posovszky P, Debatin KM
Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
1. Nat Commun - published February 1, 2022
2. Arragain B, Durieux Trouilleton Q, Baudin F, Provaznik J, Azevedo N, Cusack S, Schoehn G, Malet H
Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection.
1. PLoS Pathog - published February 1, 2022
2. Peritore-Galve FC, Shupe JA, Cave RJ, Childress KO, Washington MK, Kuehne SA, Lacy DB
Histone H2B Deacylation Selectivity: Exploring Chromatin's Dark Matter with an Engineered Sortase.
1. J Am Chem Soc - published February 1, 2022
2. Wang ZA, Whedon SD, Wu M, Wang S, Brown EA, Anmangandla A, Regan L, Lee K, Du J, Hong JY, Fairall L, Kay T, Lin H, Zhao Y, Schwabe JWR, Cole PA
An emerging mechanism for the maturation of the Small Subunit Processome.
1. Curr Opin Struct Biol - published February 1, 2022
2. Vanden Broeck A, Klinge S
Tuning Optical Absorption and Emission Using Strongly Coupled Dimers in Programmable DNA Scaffolds.
1. J Phys Chem Lett - published February 1, 2022
2. Hart SM, Wang X, Guo J, Bathe M, Schlau-Cohen GS
Visualizing protein breathing motions associated with aromatic ring flipping.
1. Nature - published February 1, 2022
2. Mariño Pérez L, Ielasi FS, Bessa LM, Maurin D, Kragelj J, Blackledge M, Salvi N, Bouvignies G, Palencia A, Jensen MR
The lipid components of high-density lipoproteins (HDL) are essential for the binding and transportation of antimicrobial peptides in human serum.
1. Sci Rep - published February 1, 2022
2. Tang WH, Wang SH, Wang CF, Mou Y, Lin MG, Hsiao CD, Liao YD
Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.
1. Nat Struct Mol Biol - published February 1, 2022
2. Andreev VI, Yu C, Wang J, Schnabl J, Tirian L, Gehre M, Handler D, Duchek P, Novatchkova M, Baumgartner L, Meixner K, Sienski G, Patel DJ, Brennecke J
Early identification of patients admitted to hospital for covid-19 at risk of clinical deterioration: model development and multisite external validation study.
1. BMJ - published February 1, 2022
2. Kamran F, Tang S, Otles E, McEvoy DS, Saleh SN, Gong J, Li BY, Dutta S, Liu X, Medford RJ, Valley TS, West LR, Singh K, Blumberg S, Donnelly JP, Shenoy ES, Ayanian JZ, Nallamothu BK, Sjoding MW, Wiens J
Classification of myeloid neoplasms/acute leukemia: global perspectives and the International Consensus Classification (ICC) approach.
1. Am J Hematol - published February 1, 2022
2. Arber DA, Hasserjian RP, Orazi A, Mathews V, Roberts AW, Schiffer CA, Roug AS, Cazzola M, Döhner H, Tefferi A
Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader.
1. Elife - published February 1, 2022
2. Gaubitz C, Liu X, Pajak J, Stone NP, Hayes JA, Demo G, Kelch BA
High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport.
1. Nat Commun - published February 1, 2022
2. Shcherbakov AA, Spreacker PJ, Dregni AJ, Henzler-Wildman KA, Hong M
Loss of LRRC33-dependent TGFβ1 activation enhances anti-tumor immunity and checkpoint blockade therapy.
1. Cancer Immunol Res - published February 1, 2022
2. Jiang A, Qin Y, Springer TA
Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.
1. J Mol Biol - published February 1, 2022
2. Zephyr J, Nageswara Rao D, Vo SV, Henes M, Kosovrasti K, Matthew AN, Hedger AK, Timm J, Chan ET, Ali A, Kurt Yilmaz N, Schiffer CA
Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome.
1. Am J Hum Genet - published February 1, 2022
2. Tessadori F, Duran K, Knapp K, Fellner M, Deciphering Developmental Disorders Study., Smithson S, Beleza Meireles A, Elting MW, Waisfisz Q, O'Donnell-Luria A, Nowak C, Douglas J, Ronan A, Brunet T, Kotzaeridou U, Svihovec S, Saenz MS, Thiffault I, Del Viso F, Devine P, Rego S, Tenney J, van Haeringen A, Ruivenkamp CAL, Koene S, Robertson SP, Deshpande C, Pfundt R, Verbeek N, van de Kamp JM, Weiss JMM, Ruiz A, Gabau E, Banne E, Pepler A, Bottani A, Laurent S, Guipponi M, Bijlsma E, Bruel AL, Sorlin A, Willis M, Powis Z, Smol T, Vincent-Delorme C, Baralle D, Colin E, Revencu N, Calpena E, Wilkie AOM, Chopra M, Cormier-Daire V, Keren B, Afenjar A, Niceta M, Terracciano A, Specchio N, Tartaglia M, Rio M, Barcia G, Rondeau S, Colson C, Bakkers J, Mace PD, Bicknell LS, van Haaften G
Regulation of GTPase function by autophosphorylation.
1. Mol Cell - published February 1, 2022
2. Johnson CW, Seo HS, Terrell EM, Yang MH, KleinJan F, Gebregiworgis T, Gasmi-Seabrook GMC, Geffken EA, Lakhani J, Song K, Bashyal P, Popow O, Paulo JA, Liu A, Mattos C, Marshall CB, Ikura M, Morrison DK, Dhe-Paganon S, Haigis KM
Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance.
1. Mol Cell - published February 1, 2022
2. Wang J, Catania S, Wang C, de la Cruz MJ, Rao B, Madhani HD, Patel DJ
Interface refinement of low- to medium-resolution Cryo-EM complexes using HADDOCK2.4.
1. Structure - published February 1, 2022
2. Neijenhuis T, van Keulen SC, Bonvin AMJJ
Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel Na_V1.5.
1. Int J Mol Sci - published February 1, 2022
2. Gulsevin A, Glazer AM, Shields T, Kroncke BM, Roden DM, Meiler J
Characterization of the First SARS-CoV-2 Isolates from Aotearoa New Zealand as Part of a Rapid Response to the COVID-19 Pandemic.
1. Viruses - published February 1, 2022
2. Harfoot R, Lawley B, Hernández LC, Kuang J, Grant J, Treece JM, LeQueux S, Day R, Jack S, Stanton JL, Bostina M, Ussher JE, Quiñones-Mateu ME
Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects macaques from infection.
1. Cell Rep Med - published February 1, 2022
2. Sulbaran G, Maisonnasse P, Amen A, Effantin G, Guilligay D, Dereuddre-Bosquet N, Burger JA, Poniman M, Grobben M, Buisson M, Dergan Dylon S, Naninck T, Lemaître J, Gros W, Gallouët AS, Marlin R, Bouillier C, Contreras V, Relouzat F, Fenel D, Thepaut M, Bally I, Thielens N, Fieschi F, Schoehn G, van der Werf S, van Gils MJ, Sanders RW, Poignard P, Le Grand R, Weissenhorn W
Sensory TRP Channels in Three Dimensions.
1. Annu Rev Biochem - published February 1, 2022
2. Diver MM, King JVL, Julius D, Cheng Y