Member Publications

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139 Member Publications for August 2021

The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-β Dependent: A Proposed Anti-inflammatory Role in Airway Disease.
1. Front Nutr - published August 30, 2021
2. Chen YH, Cheadle CE, Rice LV, Pfeffer PE, Dimeloe S, Gupta A, Bush A, Gooptu B, Hawrylowicz CM
High-Throughput Assay for Profiling the Substrate Specificity of Rab GTPase-Activating Proteins.
1. Methods Mol Biol - published August 28, 2021
2. Mishra AK, Lambright DG
Methods for Quantitative Assessment of Protein Degradation.
1. Methods Mol Biol - published August 25, 2021
2. Nowak RP, Yue H, Park EY, Fischer ES
Structural Biology in the Clouds: The WeNMR-EOSC Ecosystem.
1. Front Mol Biosci - published August 16, 2021
2. Honorato RV, Koukos PI, Jiménez-García B, Tsaregorodtsev A, Verlato M, Giachetti A, Rosato A, Bonvin AMJJ
Correction to 'RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis'.
1. Nucleic Acids Res - published August 9, 2021
2. Hefel A, Honda M, Cronin N, Harrell K, Patel P, Spies M, Smolikove S
Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function.
1. Front Cell Dev Biol - published August 9, 2021
2. Komaniecki G, Lin H
Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.
1. Nat Commun - published August 9, 2021
2. West AP Jr, Wertheim JO, Wang JC, Vasylyeva TI, Havens JL, Chowdhury MA, Gonzalez E, Fang CE, Di Lonardo SS, Hughes S, Rakeman JL, Lee HH, Barnes CO, Gnanapragasam PNP, Yang Z, Gaebler C, Caskey M, Nussenzweig MC, Keeffe JR, Bjorkman PJ
A Structurally Preserved Allosteric Site in the MIF Superfamily Affects Enzymatic Activity and CD74 Activation in D-dopachrome Tautomerase.
1. J Biol Chem - published August 9, 2021
2. Chen E, Reiss K, Shah D, Manjula R, Allen B, Murphy EL, Murphy JW, Batista VS, Bhandari V, Lolis EJ, Lisi GP
Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems.
1. Adv Drug Deliv Rev - published August 8, 2021
2. Thorn CR, Howell PL, Wozniak DJ, Prestidge CA, Thomas N
An induced-fit de novo initiation mechanism suggested by a pestivirus RNA-dependent RNA polymerase.
1. Nucleic Acids Res - published August 7, 2021
2. Zhang BY, Liu W, Jia H, Lu G, Gong P
An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates.
1. Cell Host Microbe - published August 7, 2021
2. Zabaleta N, Dai W, Bhatt U, Hérate C, Maisonnasse P, Chichester JA, Sanmiguel J, Estelien R, Michalson KT, Diop C, Maciorowski D, Dereuddre-Bosquet N, Cavarelli M, Gallouët AS, Naninck T, Kahlaoui N, Lemaitre J, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Contreras V, Marlin R, Tsong Fang RH, Chapon C, van der Werf S, Zinn E, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Le Grand R, Vandenberghe LH
Poor Humoral Response in Solid Organ Transplant Recipients following Complete mRNA SARS-CoV-2 Vaccination.
1. Clin Chem - published August 6, 2021
2. Cao J, Liu X, Muthukumar A, Gagan J, Jones P, Zu Y
Structural biology of RNA-binding proteins in the context of phase separation: What NMR and EPR can bring?
1. Curr Opin Struct Biol - published August 6, 2021
2. Emmanouilidis L, Esteban-Hofer L, Jeschke G, Allain FH
Virus-encoded histone doublets are essential and form nucleosome-like structures.
1. Cell - published August 5, 2021
2. Liu Y, Bisio H, Toner CM, Jeudy S, Philippe N, Zhou K, Bowerman S, White A, Edwards G, Abergel C, Luger K
Processing hair follicles for transmission electron microscopy.
1. Exp Dermatol - published August 5, 2021
2. Velamoor S, Mitchell A, Bostina M, Harland D
Propelling COPII vesicle biogenesis at the endoplasmic reticulum.
1. Structure - published August 5, 2021
2. Duan J, Lambright DG
Recent Applications of Dual-Stimuli Responsive Chitosan Hydrogel Nanocomposites as Drug Delivery Tools.
1. Molecules - published August 5, 2021
2. McCarthy PC, Zhang Y, Abebe F
Purification of Recombinant Wild Type and Mutant Ryanodine Receptors Expressed in HEK293 Cells.
1. Bio Protoc - published August 5, 2021
2. Hu Y, Iyer KA, Nayak AR, Kurebayashi N, Murayama T, Samsó M
In vivo active organometallic-containing antimycotic agents.
1. RSC Chem Biol - published August 5, 2021
2. Rubbiani R, Weil T, Tocci N, Mastrobuoni L, Jeger S, Moretto M, Ng J, Lin Y, Hess J, Ferrari S, Kaech A, Young L, Spencer J, Moore AL, Cariou K, Renga G, Pariano M, Romani L, Gasser G
quicksom: Self-Organizing Maps on GPUs for clustering of molecular dynamics trajectories.
1. Bioinformatics - published August 4, 2021
2. Mallet V, Nilges M, Bouvier G
Levels of circulating NS1 impact West Nile virus spread to the brain.
1. J Virol - published August 4, 2021
2. Wessel AW, Dowd KA, Biering SB, Zhang P, Edeling MA, Nelson CA, Funk KE, DeMaso CR, Klein RS, Smith JL, Cao TM, Kuhn RJ, Fremont DH, Harris E, Pierson TC, Diamond MS
Transcriptional Pausing as a Mediator of Bacterial Gene Regulation.
1. Annu Rev Microbiol - published August 4, 2021
2. Landick R
Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL^pro).
1. J Med Chem - published August 4, 2021
2. Han SH, Goins CM, Arya T, Shin WJ, Maw J, Hooper A, Sonawane DP, Porter MR, Bannister BE, Crouch RD, Lindsey AA, Lakatos G, Martinez SR, Alvarado J, Akers WS, Wang NS, Jung JU, Macdonald JD, Stauffer SR
Progression of SARS-CoV-2 Seroprevalence in St. Louis, Missouri, through January 2021.
1. mSphere - published August 4, 2021
2. Smith BK, Janowski AB, Fremont AC, Adams LJ, Dai YN, Farnsworth CW, Gronowski AM, Roper SM, Wang D, Fremont DH
Dual targeting of CTLA-4 and CD47 on T_reg cells promotes immunity against solid tumors.
1. Sci Transl Med - published August 4, 2021
2. Zhang A, Ren Z, Tseng KF, Liu X, Li H, Lu C, Cai Y, Minna JD, Fu YX
The structural basis of odorant recognition in insect olfactory receptors.
1. Nature - published August 4, 2021
2. Del Mármol J, Yedlin MA, Ruta V
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation.
1. Mol Cell - published August 4, 2021
2. Lee JH, Wang R, Xiong F, Krakowiak J, Liao Z, Nguyen PT, Moroz-Omori EV, Shao J, Zhu X, Bolt MJ, Wu H, Singh PK, Bi M, Shi CJ, Jamal N, Li G, Mistry R, Jung SY, Tsai KL, Ferreon JC, Stossi F, Caflisch A, Liu Z, Mancini MA, Li W
GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain.
1. Proc Natl Acad Sci U S A - published August 3, 2021
2. Leurs U, Klein AB, McSpadden ED, Griem-Krey N, Solbak SMØ, Houlton J, Villumsen IS, Vogensen SB, Hamborg L, Gauger SJ, Palmelund LB, Larsen ASG, Shehata MA, Kelstrup CD, Olsen JV, Bach A, Burnie RO, Kerr DS, Gowing EK, Teurlings SMW, Chi CC, Gee CL, Frølund B, Kornum BR, van Woerden GM, Clausen RP, Kuriyan J, Clarkson AN, Wellendorph P
Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity.
1. Biochemistry - published August 3, 2021
2. Thomaston JL, Samways ML, Konstantinidi A, Ma C, Hu Y, Bruce Macdonald HE, Wang J, Essex JW, DeGrado WF, Kolocouris A
Publisher Correction: Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.
1. Nature - published August 3, 2021
2. De Gasparo R, Pedotti M, Simonelli L, Nickl P, Muecksch F, Cassaniti I, Percivalle E, Lorenzi JCC, Mazzola F, Magrì D, Michalcikova T, Haviernik J, Honig V, Mrazkova B, Polakova N, Fortova A, Tureckova J, Iatsiuk V, Di Girolamo S, Palus M, Zudova D, Bednar P, Bukova I, Bianchini F, Mehn D, Nencka R, Strakova P, Pavlis O, Rozman J, Gioria S, Sammartino JC, Giardina F, Gaiarsa S, Pan-Hammarström Q, Barnes CO, Bjorkman PJ, Calzolai L, Piralla A, Baldanti F, Nussenzweig MC, Bieniasz PD, Hatziioannou T, Prochazka J, Sedlacek R, Robbiani DF, Ruzek D, Varani L
Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins.
1. Nat Commun - published August 3, 2021
2. Sharma S, Zhou R, Wan L, Feng S, Song K, Xu C, Li Y, Liao M
Virus-associated organosulfur metabolism in human and environmental systems.
1. Cell Rep - published August 3, 2021
2. Kieft K, Breister AM, Huss P, Linz AM, Zanetakos E, Zhou Z, Rahlff J, Esser SP, Probst AJ, Raman S, Roux S, Anantharaman K
Actinobacillus utilizes a binding-protein dependent ABC transporter to acquire the active form of Vitamin B₆.
1. J Biol Chem - published August 3, 2021
2. Pan C, Zimmer A, Shah M, Huynh MS, Chieh-Lin Lai C, Sit B, Hooda Y, Curran DM, Moraes TF
A composite DNA element that functions as a maintainer required for epigenetic inheritance of heterochromatin.
1. Mol Cell - published August 3, 2021
2. Wang X, Paulo JA, Li X, Zhou H, Yu J, Gygi SP, Moazed D
Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant.
1. Tetrahedron Lett - published August 3, 2021
2. Newton AS, Liosi ME, Henry SP, Deiana L, Faver JC, Krimmer SG, Puleo DE, Schlessinger J, Jorgensen WL
Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition.
1. Proc Natl Acad Sci U S A - published August 3, 2021
2. Ho CM, Jih J, Lai M, Li X, Goldberg DE, Beck JR, Zhou ZH
Quantitative analyses for effects of neddylation on CRL2^VHL substrate ubiquitination and degradation.
1. Protein Sci - published August 3, 2021
2. Wang K, Reichermeier KM, Liu X
Beth Levine M.D. Prize in Autophagy Research.
1. Autophagy - published August 3, 2021
2. Vitetta ES, Cobb MH, Hobbs HH, Hooper L, Morrison SJ, Orth K, Pfeiffer J, Rosen MK, Takahashi JS, Wang T
Compact RNA editors with small Cas13 proteins.
1. Nat Biotechnol - published August 3, 2021
2. Kannan S, Altae-Tran H, Jin X, Madigan VJ, Oshiro R, Makarova KS, Koonin EV, Zhang F
2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales.
1. Arch Virol - published August 3, 2021
2. Kuhn JH, Adkins S, Agwanda BR, Al Kubrusli R, Alkhovsky Aльxoвcкий Cepгeй Bлaдимиpoвич SV, Amarasinghe GK, Avšič-Županc T, Ayllón MA, Bahl J, Balkema-Buschmann A, Ballinger MJ, Basler CF, Bavari S, Beer M, Bejerman N, Bennett AJ, Bente DA, Bergeron É, Bird BH, Blair CD, Blasdell KR, Blystad DR, Bojko J, Borth WB, Bradfute S, Breyta R, Briese T, Brown PA, Brown JK, Buchholz UJ, Buchmeier MJ, Bukreyev A, Burt F, Büttner C, Calisher CH, Cao 曹孟籍 M, Casas I, Chandran K, Charrel RN, Cheng Q, Chiaki 千秋祐也 Y, Chiapello M, Choi IR, Ciuffo M, Clegg JCS, Crozier I, Dal Bó E, de la Torre JC, de Lamballerie X, de Swart RL, Debat H, Dheilly NM, Di Cicco E, Di Paola N, Di Serio F, Dietzgen RG, Digiaro M, Dolnik O, Drebot MA, Drexler JF, Dundon WG, Duprex WP, Dürrwald R, Dye JM, Easton AJ, Ebihara 海老原秀喜 H, Elbeaino T, Ergünay K, Ferguson HW, Fooks AR, Forgia M, Formenty PBH, Fránová J, Freitas-Astúa J, Fu 付晶晶 J, Fürl S, Gago-Zachert S, Gāo 高福 GF, García ML, García-Sastre A, Garrison AR, Gaskin T, Gonzalez JJ, Griffiths A, Goldberg TL, Groschup MH, Günther S, Hall RA, Hammond J, Han 韩彤 T, Hepojoki J, Hewson R, Hong 洪健 J, Hong 洪霓 N, Hongo 本郷誠治 S, Horie 堀江真行 M, Hu JS, Hu T, Hughes HR, Hüttner F, Hyndman TH, Ilyas M, Jalkanen R, Jiāng 姜道宏 D, Jonson GB, Junglen S, Kadono 上遠野冨士夫 F, Kaukinen KH, Kawate M, Klempa B, Klingström J, Kobinger G, Koloniuk I, Kondō 近藤秀樹 H, Koonin EV, Krupovic M, Kubota 久保田健嗣 K, Kurath G, Laenen L, Lambert AJ, Langevin SL, Lee B, Lefkowitz EJ, Leroy EM, Li 李邵蓉 S, Li 李龙辉 L, Lǐ 李建荣 J, Liu 刘华珍 H, Lukashevich IS, Maes P, de Souza WM, Marklewitz M, Marshall SH, Marzano SL, Massart S, McCauley JW, Melzer M, Mielke-Ehret N, Miller KM, Ming TJ, Mirazimi A, Mordecai GJ, Mühlbach HP, Mühlberger E, Naidu R, Natsuaki 夏秋知英 T, Navarro JA, Netesov Heтёcoв Cepгeй Bиктopoвич SV, Neumann G, Nowotny N, Nunes MRT, Olmedo-Velarde A, Palacios G, Pallás V, Pályi B, Papa Άννα Παπά A, Paraskevopoulou Σοφία Παρασκευοπούλου S, Park AC, Parrish CR, Patterson DA, Pauvolid-Corrêa A, Pawęska JT, Payne S, Peracchio C, Pérez DR, Postler TS, Qi 亓立莹 L, Radoshitzky SR, Resende RO, Reyes CA, Rima BK, Luna GR, Romanowski V, Rota P, Rubbenstroth D, Rubino L, Runstadler JA, Sabanadzovic S, Sall AA, Salvato MS, Sang R, Sasaya 笹谷孝英 T, Schulze AD, Schwemmle M, Shi 施莽 M, Shí 石晓宏 X, Shí 石正丽 Z, Shimomoto 下元祥史 Y, Shirako Y, Siddell SG, Simmonds P, Sironi M, Smagghe G, Smither S, Song 송진원 JW, Spann K, Spengler JR, Stenglein MD, Stone DM, Sugano J, Suttle CA, Tabata A, Takada 高田礼人 A, Takeuchi 竹内繁治 S, Tchouassi DP, Teffer A, Tesh RB, Thornburg NJ, Tomitaka 冨高保弘 Y, Tomonaga 朝長啓造 K, Tordo N, Torto B, Towner JS, Tsuda 津田新哉 S, Tu 涂长春 C, Turina M, Tzanetakis IE, Uchida J, Usugi 宇杉富雄 T, Vaira AM, Vallino M, van den Hoogen B, Varsani A, Vasilakis Νίκος Βασιλάκης N, Verbeek M, von Bargen S, Wada 和田治郎 J, Wahl V, Walker PJ, Wang 王林发 LF, Wang 王国平 G, Wang 王雁翔 Y, Wang 王亚琴 Y, Waqas M, Wèi 魏太云 T, Wen 温少华 S, Whitfield AE, Williams JV, Wolf YI, Wu 吴建祥 J, Xu 徐雷 L, Yanagisawa 栁澤広宣 H, Yang 杨彩霞 C, Yang 杨作坤 Z, Zerbini FM, Zhai 翟立峰 L, Zhang 张永振 YZ, Zhang 张松 S, Zhang 张靖国 J, Zhang 张哲 Z, Zhou 周雪平 X
Cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein.
1. Cell Rep - published August 3, 2021
2. Doyle MP, Kose N, Borisevich V, Binshtein E, Amaya M, Nagel M, Annand EJ, Armstrong E, Bombardi R, Dong J, Schey KL, Broder CC, Zeitlin L, Kuang EA, Bornholdt ZA, West BR, Geisbert TW, Cross RW, Crowe JE Jr
Intra- and extra-cellular environments contribute to the fate of HIV-1 infection.
1. Cell Rep - published August 3, 2021
2. Ratnapriya S, Harris M, Chov A, Herbert ZT, Vrbanac V, Deruaz M, Achuthan V, Engelman AN, Sodroski J, Herschhorn A
Cryo-EM structures of human TMEM120A and TMEM120B.
1. Cell Discov - published August 3, 2021
2. Ke M, Yu Y, Zhao C, Lai S, Su Q, Yuan W, Yang L, Deng D, Wu K, Zeng W, Geng J, Wu J, Yan Z
The transmembrane amyloid precursor C99 protein exhibits non-specific interaction with tau.
1. Biochem Biophys Res Commun - published August 3, 2021
2. Britton RJ, Hutchison JM, Sanders CR
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
1. Cell - published August 3, 2021
2. Zhang K, Julius D, Cheng Y
DNA Helicase-Polymerase Coupling in Bacteriophage DNA Replication.
1. Viruses - published August 3, 2021
2. Lo CY, Gao Y
CaMn₃ ^IV O₄ Cubane Models of the Oxygen-Evolving Complex: Spin Ground States S<9/2 and the Effect of Oxo Protonation.
1. Angew Chem Int Ed Engl - published August 2, 2021
2. Lee HB, Shiau AA, Marchiori DA, Oyala PH, Yoo BK, Kaiser JT, Rees DC, Britt RD, Agapie T
Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore.
1. J Cell Biol - published August 2, 2021
2. Quan Y, Hinshaw SM, Wang PC, Harrison SC, Zhou H
Structural and functional studies of the first tripartite protein complex at the Trypanosoma brucei flagellar pocket collar.
1. PLoS Pathog - published August 2, 2021
2. Isch C, Majneri P, Landrein N, Pivovarova Y, Lesigang J, Lauruol F, Robinson DR, Dong G, Bonhivers M
Proteo-Genomic Analysis Identifies Two Major Sites of Vulnerability on Ebolavirus Glycoprotein for Neutralizing Antibodies in Convalescent Human Plasma.
1. Front Immunol - published August 2, 2021
2. Gilchuk P, Guthals A, Bonissone SR, Shaw JB, Ilinykh PA, Huang K, Bombardi RG, Liang J, Grinyo A, Davidson E, Chen EC, Gunn BM, Alter G, Saphire EO, Doranz BJ, Bukreyev A, Zeitlin L, Castellana N, Crowe JE Jr
An automated iterative approach for protein structure refinement using pseudocontact shifts.
1. J Biomol NMR - published August 2, 2021
2. Cucuzza S, Güntert P, Plückthun A, Zerbe O
The zinc transporter ZnuABC is critical for the virulence of Chromobacterium violaceum and contributes to diverse zinc-dependent physiological processes.
1. Infect Immun - published August 2, 2021
2. Santos RERS, da Silva Júnior WP, Harrison S, Skaar EP, Chazin WJ, da Silva Neto JF
Insights into the bilayer-mediated toppling mechanism of a folate-specific ECF transporter by cryo-EM.
1. Proc Natl Acad Sci U S A - published August 2, 2021
2. Thangaratnarajah C, Rheinberger J, Paulino C, Slotboom DJ
Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery.
1. Science - published August 2, 2021
2. Segel M, Lash B, Song J, Ladha A, Liu CC, Jin X, Mekhedov SL, Macrae RK, Koonin EV, Zhang F
Folding and misfolding of potassium channel monomers during assembly and tetramerization.
1. Proc Natl Acad Sci U S A - published August 2, 2021
2. Song KC, Molina AV, Chen R, Gagnon IA, Koh YH, Roux B, Sosnick TR
Corrigendum to "Hippo/YAP signaling pathway mitigates blood-brain barrier disruption after cerebral ischemia/reperfusion injury" [Behav. Brain Res. 356 (2019) 8-17].
1. Behav Brain Res - published August 2, 2021
2. Gong P, Zhang Z, Zou C, Tian Q, Chen X, Hong M, Liu X, Chen Q, Xu Z, Li M, Wang J
S-acylation of SARS-CoV-2 Spike Protein: Mechanistic Dissection, In Vitro Reconstitution and Role in Viral Infectivity.
1. J Biol Chem - published August 2, 2021
2. Puthenveetil R, Lun CM, Murphy RE, Healy LB, Vilmen G, Christenson ET, Freed EO, Banerjee A
Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering.
1. mBio - published August 2, 2021
2. Thorsen MK, Lai A, Lee MW, Hoogerheide DP, Wong GCL, Freed JH, Heldwein EE
SARS-CoV-2 Neutralizing Antibodies for COVID-19 Prevention and Treatment.
1. Annu Rev Med - published August 2, 2021
2. Li D, Sempowski GD, Saunders KO, Acharya P, Haynes BF
Translocation expands the scope of the large clostridial toxin family.
1. Trends Biochem Sci - published August 2, 2021
2. Orrell KE, Melnyk RA
Structural insights into GIRK2 channel modulation by cholesterol and PIP₂.
1. Cell Rep - published August 2, 2021
2. Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA
1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors.
1. J Med Chem - published August 2, 2021
2. Dolbois A, Bedi RK, Bochenkova E, Müller A, Moroz-Omori EV, Huang D, Caflisch A
Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC.
1. Nat Commun - published August 2, 2021
2. Silberberg JM, Corey RA, Hielkema L, Stock C, Stansfeld PJ, Paulino C, Hänelt I
Shape-Restrained Modeling of Protein-Small-Molecule Complexes with High Ambiguity Driven DOCKing.
1. J Chem Inf Model - published August 2, 2021
2. Koukos PI, Réau M, Bonvin AMJJ
Human antibody recognition of H7N9 influenza virus hemagglutinin following natural infection.
1. JCI Insight - published August 2, 2021
2. Gilchuk IM, Bangaru S, Kose N, Bombardi RG, Trivette A, Li S, Turner HL, Carnahan RH, Ward AB, Crowe JE Jr
Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease.
1. ACS Infect Dis - published August 2, 2021
2. MacDonald EA, Frey G, Namchuk MN, Harrison SC, Hinshaw SM, Windsor IW
Phosphatidylserine binding directly regulates TIM-3 function.
1. Biochem J - published August 2, 2021
2. Smith C, Li A, Krishnamurthy N, Lemmon MA
Plant genome engineering from lab to field-a Keystone Symposia report.
1. Ann N Y Acad Sci - published August 2, 2021
2. Cable J, Ronald PC, Voytas D, Zhang F, Levy AA, Takatsuka A, Arimura SI, Jacobsen SE, Toki S, Toda E, Gao C, Zhu JK, Boch J, Van Eck J, Mahfouz M, Andersson M, Fridman E, Weiss T, Wang K, Qi Y, Jores T, Adams T, Bagchi R
The opportunity cost of automated glycopeptide analysis: case study profiling the SARS-CoV-2 S glycoprotein.
1. Anal Bioanal Chem - published August 2, 2021
2. Go EP, Zhang S, Ding H, Kappes JC, Sodroski J, Desaire H
Bend, Push, Stretch: Remarkable Structure and Mechanics of Single Intermediate Filaments and Meshworks.
1. Cells - published August 2, 2021
2. Sapra KT, Medalia O
Generation of novel long-acting GLP-1R agonists using DARPins as a scaffold.
1. Int J Pharm - published August 2, 2021
2. Tan H, Su W, Zhang W, Zhang J, Sattler M, Zou Resource P
New insights into Raf regulation from structural analyses.
1. Curr Opin Struct Biol - published August 2, 2021
2. Kondo Y, Paul JW 3rd, Subramaniam S, Kuriyan J
¹H, ¹³C and ¹⁵N assignment of stem-loop SL1 from the 5'-UTR of SARS-CoV-2.
1. Biomol NMR Assign - published August 2, 2021
2. Richter C, Hohmann KF, Toews S, Mathieu D, Altincekic N, Bains JK, Binas O, Ceylan B, Duchardt-Ferner E, Ferner J, Fürtig B, Grün JT, Hengesbach M, Hymon D, Jonker HRA, Knezic B, Korn SM, Landgraf T, Löhr F, Peter SA, Pyper DJ, Qureshi NS, Schlundt A, Schnieders R, Stirnal E, Sudakov A, Vögele J, Weigand JE, Wirmer-Bartoschek J, Witt K, Wöhnert J, Schwalbe H, Wacker A
SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicity.
1. J Biol Chem - published August 2, 2021
2. Olia AS, Tsybovsky Y, Chen SJ, Liu C, Nazzari AF, Ou L, Wang L, Kong WP, Leung K, Liu T, Stephens T, Teng IT, Wang S, Yang ES, Zhang B, Zhang Y, Zhou T, Mascola JR, Kwong PD
Cryo-EM density maps adjustment for subtraction, consensus and sharpening.
1. J Struct Biol - published August 2, 2021
2. Fernández-Giménez E, Martínez M, Sánchez-García R, Marabini R, Ramírez-Aportela E, Conesa P, Carazo JM, Sorzano COS
Cysteine derivatives as acetyl lysine mimics to inhibit zinc-dependent histone deacetylases for treating cancer.
1. Eur J Med Chem - published August 2, 2021
2. Wang J, Cao Z, Wang F, Wang P, An J, Fu X, Liu T, Li Y, Li Y, Zhao Y, Lin H, He B
Revisiting the CooJ family, a potential chaperone for nickel delivery to [NiFe]‑carbon monoxide dehydrogenase.
1. J Inorg Biochem - published August 2, 2021
2. Darrouzet E, Rinaldi C, Zambelli B, Ciurli S, Cavazza C
Lassa Fever Virus Binds Matriglycan-A Polymer of Alternating Xylose and Glucuronate-On α-Dystroglycan.
1. Viruses - published August 2, 2021
2. Joseph S, Campbell KP
Structural basis of the (in)activity of the apical DNA damage response kinases ATM, ATR and DNA-PKcs.
1. Prog Biophys Mol Biol - published August 1, 2021
2. Jansma M, Hopfner KP
Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease.
1. bioRxiv - published August 1, 2021
2. Kreutzberger AJB, Sanyal A, Ojha R, Pyle JD, Vapalahti O, Balistreri G, Kirchhausen T
Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress.
1. Life Sci Alliance - published August 1, 2021
2. Huttunen M, Samolej J, Evans RJ, Yakimovich A, White IJ, Kriston-Vizi J, Martin-Serrano J, Sundquist WI, Frickel EM, Mercer J
GRB2 enforces homology-directed repair initiation by MRE11.
1. Sci Adv - published August 1, 2021
2. Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, Tsai CL, Shen Q, Peng G, Leonard PG, Jones DE, Wang B, Tainer JA, Ahmed Z
Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex.
1. mBio - published August 1, 2021
2. Cherrak Y, Filella-Merce I, Schmidt V, Byrne D, Sgoluppi V, Chaiaheloudjou R, Betzi S, Morelli X, Nilges M, Pellarin R, Durand E
Analysis of the Mechanosensor Channel Functionality of TACAN.
1. Elife - published August 1, 2021
2. Niu Y, Tao X, Vaisey G, Olinares PDB, Alwaseem H, Chait B, MacKinnon R
SARS-CoV-2 Viremia is Associated with COVID-19 Severity and Predicts Clinical Outcomes.
1. Clin Infect Dis - published August 1, 2021
2. Jacobs JL, Bain W, Naqvi A, Staines B, Castanha PMS, Yang H, Boltz VF, Barratt-Boyes S, Marques ETA, Mitchell SL, Methé B, Olonisakin TF, Haidar G, Burke TW, Petzold E, Denny T, Woods CW, McVerry BJ, Lee JS, Watkins SC, St Croix CM, Morris A, Kearney MF, Ladinsky MS, Bjorkman PJ, Kitsios G, Mellors JW
TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase.
1. Elife - published August 1, 2021
2. Xue J, Han Y, Baniasadi H, Zeng W, Pei J, Grishin NV, Wang J, Tu BP, Jiang Y
High-Throughput Enzyme Assay for Screening Inhibitors of the ZDHHC3/7/20 Acyltransferases.
1. ACS Chem Biol - published August 1, 2021
2. Hong JY, Malgapo MIP, Liu Y, Yang M, Zhu C, Zhang X, Tolbert P, Linder ME, Lin H
Preparative production of an enantiomeric pair by engineered polyketide synthases.
1. Chem Commun (Camb) - published August 1, 2021
2. Miyazawa T, Fitzgerald BJ, Keatinge-Clay AT
Investigation of the enzymes required for the biosynthesis of an unusual formylated sugar in the emerging human pathogen Helicobacter canadensis.
1. Protein Sci - published August 1, 2021
2. Heisdorf CJ, Griffiths WA, Thoden JB, Holden HM
Bacteriophage λ RexA and RexB Functions Assist the Transition from Lysogeny to Lytic Growth.
1. Mol Microbiol - published August 1, 2021
2. Thomason LC, Schiltz CJ, Court C, Hosford CJ, Adams MC, Chappie JS, Court DL
High-Throughput Screening Identifies Ascorbyl Palmitate As a SIRT2 Deacetylase and Defatty-Acylase Inhibitor.
1. ChemMedChem - published August 1, 2021
2. Hong JY, Cassel J, Yang J, Lin H, Weiser BP
Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus and Human Rhinoviruses.
1. ChemMedChem - published August 1, 2021
2. Martina MG, Vicenti I, Bauer L, Crespan E, Rango E, Boccuto A, Olivieri N, Incerti M, Zwaagstra M, Allodi M, Bertoni S, Dreassi E, Zazzi M, van Kuppeveld FJM, Maga G, Radi M
Footprinting Mass Spectrometry of Membrane Proteins: Ferroportin Reconstituted in Saposin A Picodiscs.
1. Anal Chem - published August 1, 2021
2. Zhou F, Yang Y, Chemuru S, Cui W, Liu S, Gross M, Li W
Development and Validation of Unplanned Extubation Prediction Models Using Intensive Care Unit Data: Retrospective, Comparative, Machine Learning Study.
1. J Med Internet Res - published August 1, 2021
2. Hur S, Min JY, Yoo J, Kim K, Chung CR, Dykes PC, Cha WC
DNA interference states of the hypercompact CRISPR-CasΦ effector.
1. Nat Struct Mol Biol - published August 1, 2021
2. Pausch P, Soczek KM, Herbst DA, Tsuchida CA, Al-Shayeb B, Banfield JF, Nogales E, Doudna JA
RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
1. Proc Natl Acad Sci U S A - published August 1, 2021
2. Castel P, Dharmaiah S, Sale MJ, Messing S, Rizzuto G, Cuevas-Navarro A, Cheng A, Trnka MJ, Urisman A, Esposito D, Simanshu DK, McCormick F
Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions.
1. Nat Commun - published August 1, 2021
2. Sukalskaia A, Straub MS, Deneka D, Sawicka M, Dutzler R
Patched regulates lipid homeostasis by controlling cellular cholesterol levels.
1. Nat Commun - published August 1, 2021
2. Cadena Del Castillo CE, Hannich JT, Kaech A, Chiyoda H, Brewer J, Fukuyama M, Færgeman NJ, Riezman H, Spang A
Physical basis for distinct basal and mechanically gated activity of the human K⁺ channel TRAAK.
1. Neuron - published August 1, 2021
2. Rietmeijer RA, Sorum B, Li B, Brohawn SG
The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core.
1. Nat Commun - published August 1, 2021
2. Bloch NB, Wales TE, Prew MS, Levy HR, Engen JR, Walensky LD
SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns.
1. Nat Commun - published August 1, 2021
2. Fukumura K, Yoshimoto R, Sperotto L, Kang HS, Hirose T, Inoue K, Sattler M, Mayeda A
Identification of Ubiquitin Variants That Inhibit the E2 Ubiquitin Conjugating Enzyme, Ube2k.
1. ACS Chem Biol - published August 1, 2021
2. Middleton AJ, Teyra J, Zhu J, Sidhu SS, Day CL
Correction to: On the Role of a Conserved Methionine in the Na⁺-Coupling Mechanism of a Neurotransmitter Transporter Homolog.
1. Neurochem Res - published August 1, 2021
2. Zhou W, Trinco G, Slotboom DJ, Forrest LR, Faraldo-Gómez JD
Improved immunologic responses to heterologous influenza strains in children with low preexisting antibody response vaccinated with MF59-adjuvanted influenza vaccine.
1. Vaccine - published August 1, 2021
2. Palladino G, Ferrari A, Music N, Settembre EC, Wen Y
Engineering Single Pan-Specific Ubiquibodies for Targeted Degradation of All Forms of Endogenous ERK Protein Kinase.
1. ACS Synth Biol - published August 1, 2021
2. Stephens EA, Ludwicki MB, Meksiriporn B, Li M, Ye T, Monticello C, Forsythe KJ, Kummer L, Zhou P, Plückthun A, DeLisa MP
Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.
1. Nat Commun - published August 1, 2021
2. Agnew C, Ayaz P, Kashima R, Loving HS, Ghatpande P, Kung JE, Underbakke ES, Shan Y, Shaw DE, Hata A, Jura N
Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1.
1. Nat Commun - published August 1, 2021
2. Pan C, Kang J, Hwang JS, Li J, Boese AC, Wang X, Yang L, Boggon TJ, Chen GZ, Saba NF, Shin DM, Magliocca KR, Jin L, Kang S
A Widespread Bacterial Secretion System with Diverse Substrates.
1. mBio - published August 1, 2021
2. Grossman AS, Mauer TJ, Forest KT, Goodrich-Blair H
Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3).
1. Nucleic Acids Res - published August 1, 2021
2. Li K, Zheng J, Wirawan M, Trinh NM, Fedorova O, Griffin PR, Pyle AM, Luo D
Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.
1. J Med Chem - published August 1, 2021
2. Nageswara Rao D, Zephyr J, Henes M, Chan ET, Matthew AN, Hedger AK, Conway HL, Saeed M, Newton A, Petropoulos CJ, Huang W, Kurt Yilmaz N, Schiffer CA, Ali A
Mechanisms of hexameric helicases.
1. Crit Rev Biochem Mol Biol - published August 1, 2021
2. Fernandez AJ, Berger JM
Ponatinib Dose-Ranging Study in Chronic-Phase Chronic Myeloid Leukemia: A Randomized, Open-Label Phase 2 Clinical Trial.
1. Blood - published August 1, 2021
2. Cortes J, Apperley JF, Lomaia E, Moiraghi B, Undurraga MS, Pavlovsky C, Chuah C, Sacha T, Lipton JH, Schiffer CA, McCloskey J, Hochhaus A, Rousselot P, Rosti G, de Lavallade H, Turkina A, Rojas C, Arthur C, Maness LJ, Talpaz M, Mauro MJ, Hall T, Lu V, Srivastava S, Deininger MW
Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs.
1. Mol Biol Cell - published August 1, 2021
2. Fabritius AS, Bayless BA, Li S, Stoddard D, Heydeck W, Ebmeier CC, Anderson L, Gunnels T, Nachiappan C, Whittall JB, Old W, Agard DA, Nicastro D, Winey M
Structural and mechanistic basis for protein glutamylation by the kinase fold.
1. Mol Cell - published August 1, 2021
2. Osinski A, Black MH, Pawłowski K, Chen Z, Li Y, Tagliabracci VS
Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease.
1. J Virol - published August 1, 2021
2. Kreutzberger AJB, Sanyal A, Ojha R, Pyle JD, Vapalahti O, Balistreri G, Kirchhausen T
A synonymous coding variant that alters ALAS2 splicing and causes X-linked sideroblastic anemia.
1. Pediatr Blood Cancer - published August 1, 2021
2. Oakley JH, Campagna DR, Sun L, Rockowitz S, Sliz P, Boudreaux J, Woods G, Fleming MD
Characterization of the ABC methionine transporter from Neisseria meningitidis reveals that lipidated MetQ is required for interaction.
1. Elife - published August 1, 2021
2. Sharaf NG, Shahgholi M, Kim E, Lai JY, VanderVelde DG, Lee AT, Rees DC
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation.
1. Nat Commun - published August 1, 2021
2. Sun Y, Chen J, Huang SN, Su YP, Wang W, Agama K, Saha S, Jenkins LM, Pascal JM, Pommier Y
Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.
1. ACS Med Chem Lett - published August 1, 2021
2. Zhang CH, Spasov KA, Reilly RA, Hollander K, Stone EA, Ippolito JA, Liosi ME, Deshmukh MG, Tirado-Rives J, Zhang S, Liang Z, Miller SJ, Isaacs F, Lindenbach BD, Anderson KS, Jorgensen WL
¹H, ¹⁵ N and ¹³C resonance assignments of the C-terminal domain of PulL, a component of the Klebsiella oxytoca type II secretion system.
1. Biomol NMR Assign - published August 1, 2021
2. Dazzoni R, López-Castilla A, Cordier F, Bardiaux B, Nilges M, Francetic O, Izadi-Pruneyre N
Targeted Degradation of the Oncogenic Phosphatase SHP2.
1. Biochemistry - published August 1, 2021
2. Vemulapalli V, Donovan KA, Seegar TCM, Rogers JM, Bae M, Lumpkin RJ, Cao R, Henke MT, Ray SS, Fischer ES, Cuny GD, Blacklow SC
Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals.
1. Cell Rep - published August 1, 2021
2. Chen EC, Gilchuk P, Zost SJ, Suryadevara N, Winkler ES, Cabel CR, Binshtein E, Chen RE, Sutton RE, Rodriguez J, Day S, Myers L, Trivette A, Williams JK, Davidson E, Li S, Doranz BJ, Campos SK, Carnahan RH, Thorne CA, Diamond MS, Crowe JE Jr
Light-responsive and Protic Ruthenium Compounds Bearing Bathophenanthroline and Dihydroxybipyridine Ligands Achieve Nanomolar Toxicity towards Breast Cancer Cells.
1. Photochem Photobiol - published August 1, 2021
2. Oladipupo O, Brown SR, Lamb RW, Gray JL, Cameron CG, DeRegnaucourt AR, Ward NA, Hall JF, Xu Y, Petersen CM, Qu F, Shrestha AB, Thompson MK, Bonizzoni M, Webster CE, McFarland SA, Kim Y, Papish ET
Blocking α₄β₇ integrin delays viral rebound in SHIV_SF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies.
1. Sci Transl Med - published August 1, 2021
2. Frank I, Cigoli M, Arif MS, Fahlberg MD, Maldonado S, Calenda G, Pegu A, Yang ES, Rawi R, Chuang GY, Geng H, Liu C, Zhou T, Kwong PD, Arthos J, Cicala C, Grasperge BF, Blanchard JL, Gettie A, Fennessey CM, Keele BF, Vaccari M, Hope TJ, Fauci AS, Mascola JR, Martinelli E
Titratable transmembrane residues and a hydrophobic plug are essential for manganese import via the Bacillus anthracis ABC transporter MntBC-A.
1. J Biol Chem - published August 1, 2021
2. Kuznetsova A, Masrati G, Vigonsky E, Livnat-Levanon N, Rose J, Grupper M, Baloum A, Yang JG, Rees DC, Ben-Tal N, Lewinson O
Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress.
1. Cell - published August 1, 2021
2. Williamson LE, Reeder KM, Bailey K, Tran MH, Roy V, Fouch ME, Kose N, Trivette A, Nargi RS, Winkler ES, Kim AS, Gainza C, Rodriguez J, Armstrong E, Sutton RE, Reidy J, Carnahan RH, McDonald WH, Schoeder CT, Klimstra WB, Davidson E, Doranz BJ, Alter G, Meiler J, Schey KL, Julander JG, Diamond MS, Crowe JE Jr
Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans.
1. Genes Dev - published August 1, 2021
2. Perez-Borrajero C, Podvalnaya N, Holleis K, Lichtenberger R, Karaulanov E, Simon B, Basquin J, Hennig J, Ketting RF, Falk S
Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope.
1. Cell - published August 1, 2021
2. Kim AS, Kafai NM, Winkler ES, Gilliland TC Jr, Cottle EL, Earnest JT, Jethva PN, Kaplonek P, Shah AP, Fong RH, Davidson E, Malonis RJ, Quiroz JA, Williamson LE, Vang L, Mack M, Crowe JE Jr, Doranz BJ, Lai JR, Alter G, Gross ML, Klimstra WB, Fremont DH, Diamond MS
Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development.
1. ACS Med Chem Lett - published August 1, 2021
2. Teng M, Jiang J, Ficarro SB, Seo HS, Bae JH, Donovan KA, Fischer ES, Zhang T, Dhe-Paganon S, Marto JA, Gray NS
Molecular insights into the biased signaling mechanism of the μ-opioid receptor.
1. Mol Cell - published August 1, 2021
2. Cong X, Maurel D, Déméné H, Vasiliauskaité-Brooks I, Hagelberger J, Peysson F, Saint-Paul J, Golebiowski J, Granier S, Sounier R
A capillary-based microfluidic device enables primary high-throughput room-temperature crystallographic screening.
1. J Appl Crystallogr - published August 1, 2021
2. Sui S, Mulichak A, Kulathila R, McGee J, Filiatreault D, Saha S, Cohen A, Song J, Hung H, Selway J, Kirby C, Shrestha OK, Weihofen W, Fodor M, Xu M, Chopra R, Perry SL
The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site.
1. Toxins (Basel) - published August 1, 2021
2. Gulsevin A, Papke RL, Stokes C, Tran HNT, Jin AH, Vetter I, Meiler J
Rational Design of Constrained Peptides as Protein Interface Inhibitors.
1. Antibodies (Basel) - published August 1, 2021
2. Murali R, Zhang H, Cai Z, Lam L, Greene M
Enthalpy-Entropy Compensation in the Promiscuous Interaction of an Intrinsically Disordered Protein with Homologous Protein Partners.
1. Biomolecules - published August 1, 2021
2. Kragelj J, Orand T, Delaforge E, Tengo L, Blackledge M, Palencia A, Jensen MR
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy.
1. Immunity - published August 1, 2021
2. Ullah I, Prévost J, Ladinsky MS, Stone H, Lu M, Anand SP, Beaudoin-Bussières G, Symmes K, Benlarbi M, Ding S, Gasser R, Fink C, Chen Y, Tauzin A, Goyette G, Bourassa C, Medjahed H, Mack M, Chung K, Wilen CB, Dekaban GA, Dikeakos JD, Bruce EA, Kaufmann DE, Stamatatos L, McGuire AT, Richard J, Pazgier M, Bjorkman PJ, Mothes W, Finzi A, Kumar P, Uchil PD
Thermodynamic Stability Is a Strong Predictor for the Delivery of DARPins to the Cytosol via Anthrax Toxin.
1. Pharmaceutics - published August 1, 2021
2. Becker L, Singh Badwal J, Brandl F, Verdurmen WPR, Plückthun A
Selective degradation-inducing probes for studying cereblon (CRBN) biology.
1. RSC Med Chem - published August 1, 2021
2. Powell CE, Du G, Bushman JW, He Z, Zhang T, Fischer ES, Gray NS
Mutant HER2 needs mutant HER3 to be an effective oncogene.
1. Cell Rep Med - published August 1, 2021
2. Trenker R, Diwanji D, Jura N
A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope.
1. Immunity - published August 1, 2021
2. VanBlargan LA, Adams LJ, Liu Z, Chen RE, Gilchuk P, Raju S, Smith BK, Zhao H, Case JB, Winkler ES, Whitener BM, Droit L, Aziati ID, Bricker TL, Joshi A, Shi PY, Creanga A, Pegu A, Handley SA, Wang D, Boon ACM, Crowe JE Jr, Whelan SPJ, Fremont DH, Diamond MS