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141 Member Publications for July 2021

A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention.
1. MAbs - published July 30, 2021
2. Kwon YD, Asokan M, Gorman J, Zhang B, Liu Q, Louder MK, Lin BC, McKee K, Pegu A, Verardi R, Yang ES, Program VP, Carlton K, Doria-Rose NA, Lusso P, Mascola JR, Kwong PD
The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation.
1. Front Cell Dev Biol - published July 23, 2021
2. Rashed F, Kamijyo S, Shimizu Y, Hirohashi Y, Khan M, Sugamori Y, Murali R, Aoki K
Methods to Screen for Radical SAM Enzyme Crystallization Conditions.
1. Methods Mol Biol - published July 22, 2021
2. Martin L, Vernède X, Nicolet Y
Animal- versus in vitro-derived antibodies: avoiding the extremes.
1. MAbs - published July 20, 2021
2. Bradbury ARM, Dübel S, Knappik A, Plückthun A
Corrigendum: A Markerless Method for Genome Engineering in Zymomonas mobilis ZM4.
1. Front Microbiol - published July 19, 2021
2. Lal PB, Wells FM, Lyu Y, Ghosh IN, Landick R, Kiley PJ
Selective Nutrient Transport in Bacteria: Multicomponent Transporter Systems Reign Supreme.
1. Front Mol Biosci - published July 16, 2021
2. Davies JS, Currie MJ, Wright JD, Newton-Vesty MC, North RA, Mace PD, Allison JR, Dobson RCJ
Disabling the Nuclear Translocalization of RelA/NF-κB by a Small Molecule Inhibits Triple-Negative Breast Cancer Growth.
1. Breast Cancer (Dove Med Press) - published July 15, 2021
2. Kanzaki H, Chatterjee A, Hossein Nejad Ariani H, Zhang X, Chung S, Deng N, Ramanujan VK, Cui X, Greene MI, Murali R
Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.
1. Immunity - published July 13, 2021
2. Sharif H, Hollingsworth LR, Griswold AR, Hsiao JC, Wang Q, Bachovchin DA, Wu H
Reining in BTK: Interdomain Interactions and Their Importance in the Regulatory Control of BTK.
1. Front Cell Dev Biol - published July 12, 2021
2. Kueffer LE, Joseph RE, Andreotti AH
Glycolysis-Related Gene Expression Profiling Screen for Prognostic Risk Signature of Pancreatic Ductal Adenocarcinoma.
1. Front Genet - published July 12, 2021
2. Song W, He X, Gong P, Yang Y, Huang S, Zeng Y, Wei L, Zhang J
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses.
1. bioRxiv - published July 9, 2021
2. Feldman J, Bals J, Altomare CG, St Denis K, Lam EC, Hauser BM, Ronsard L, Sangesland M, Moreno TB, Okonkwo V, Hartojo N, Balazs AB, Bajic G, Lingwood D, Schmidt AG
Ligand-binding and -scavenging of the chemerin receptor GPR1.
1. Cell Mol Life Sci - published July 9, 2021
2. Fischer TF, Czerniak AS, Weiß T, Schoeder CT, Wolf P, Seitz O, Meiler J, Beck-Sickinger AG
Ultrastructure of influenza virus ribonucleoprotein complexes during viral RNA synthesis.
1. Commun Biol - published July 9, 2021
2. Nakano M, Sugita Y, Kodera N, Miyamoto S, Muramoto Y, Wolf M, Noda T
Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.
1. Nat Commun - published July 9, 2021
2. Xu K, Wang Y, Shen CH, Chen Y, Zhang B, Liu K, Tsybovsky Y, Wang S, Farney SK, Gorman J, Stephens T, Verardi R, Yang Y, Zhou T, Chuang GY, Lanzavecchia A, Piccoli L, Kwong PD
Cyclohexyl-α maltoside as a highly efficient tool for membrane protein studies.
1. Curr Res Struct Biol - published July 8, 2021
2. Missel JW, Salustros N, Becares ER, Steffen JH, Laursen AG, Garcia AS, Garcia-Alai MM, Kolar Č, Gourdon P, Gotfryd K
Biochemical and structural characterization of two cif-like epoxide hydrolases from Burkholderia cenocepacia.
1. Curr Res Struct Biol - published July 8, 2021
2. Taher NM, Hvorecny KL, Burke CM, Gilman MSA, Heussler GE, Adolf-Bryfogle J, Bahl CD, O'Toole GA, Madden DR
Saccharomyces cerevisiae as a superior host for overproduction of prokaryotic integral membrane proteins.
1. Curr Res Struct Biol - published July 8, 2021
2. Preisler SS, Wiuf AD, Friis M, Kjaergaard L, Hurd M, Becares ER, Nurup CN, Bjoerkskov FB, Szathmáry Z, Gourdon PE, Calloe K, Klaerke DA, Gotfryd K, Pedersen PA
Structural basis of elongation factor 2 switching.
1. Curr Res Struct Biol - published July 8, 2021
2. Fenwick MK, Ealick SE
METTL3 inhibitors for epitranscriptomic modulation of cellular processes.
1. ChemMedChem - published July 8, 2021
2. Moroz-Omori EV, Huang D, Bedi RK, Cheriyamkunnel SJ, Bochenkova E, Dolbois A, Rzeczkowski MD, Li Y, Wiedmer L, Caflisch A
A Multitask Deep-Learning Method for Predicting Membrane Associations and Secondary Structures of Proteins.
1. J Proteome Res - published July 8, 2021
2. Li B, Mendenhall J, Capra JA, Meiler J
K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.
1. Nat Chem Biol - published July 8, 2021
2. Yu Y, Zheng Q, Erramilli SK, Pan M, Park S, Xie Y, Li J, Fei J, Kossiakoff AA, Liu L, Zhao M
Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546.
1. ACS Med Chem Lett - published July 8, 2021
2. Ma B, Zhang L, Sun L, Xin Z, Kumaravel G, Marcotte D, Chodaparambil JV, Wang Q, Wehr A, Jing J, Hong VS, Wang T, Huang C, Shao Z, Mi S
Ribosome-associated quality control and CAT tailing.
1. Crit Rev Biochem Mol Biol - published July 7, 2021
2. Howard CJ, Frost A
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies.
1. Nat Commun - published July 7, 2021
2. Greaney AJ, Starr TN, Barnes CO, Weisblum Y, Schmidt F, Caskey M, Gaebler C, Cho A, Agudelo M, Finkin S, Wang Z, Poston D, Muecksch F, Hatziioannou T, Bieniasz PD, Robbiani DF, Nussenzweig MC, Bjorkman PJ, Bloom JD
Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss.
1. Sci Transl Med - published July 7, 2021
2. Rodriguez S, Sahin A, Schrank BR, Al-Lawati H, Costantino I, Benz E, Fard D, Albers AD, Cao L, Gomez AC, Evans K, Ratti E, Cudkowicz M, Frosch MP, Talkowski M, Sorger PK, Hyman BT, Albers MW
Sexual arousal gates visual processing during Drosophila courtship.
1. Nature - published July 7, 2021
2. Hindmarsh Sten T, Li R, Otopalik A, Ruta V
Structural basis of the stereoselective formation of the spirooxindole ring in the biosynthesis of citrinadins.
1. Nat Commun - published July 6, 2021
2. Liu Z, Zhao F, Zhao B, Yang J, Ferrara J, Sankaran B, Venkataram Prasad BV, Kundu BB, Phillips GN Jr, Gao Y, Hu L, Zhu T, Gao X
Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease.
1. Cell Rep - published July 6, 2021
2. Fonseca-Ornelas L, Viennet T, Rovere M, Jiang H, Liu L, Nuber S, Ericsson M, Arthanari H, Selkoe DJ
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.
1. J Exp Med - published July 5, 2021
2. Le Coz C, Nguyen DN, Su C, Nolan BE, Albrecht AV, Xhani S, Sun D, Demaree B, Pillarisetti P, Khanna C, Wright F, Chen PA, Yoon S, Stiegler AL, Maurer K, Garifallou JP, Rymaszewski A, Kroft SH, Olson TS, Seif AE, Wertheim G, Grant SFA, Vo LT, Puck JM, Sullivan KE, Routes JM, Zakharova V, Shcherbina A, Mukhina A, Rudy NL, Hurst ACE, Atkinson TP, Boggon TJ, Hakonarson H, Abate AR, Hajjar J, Nicholas SK, Lupski JR, Verbsky J, Chinn IK, Gonzalez MV, Wells AD, Marson A, Poon GMK, Romberg N
Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.
1. J Cell Biol - published July 5, 2021
2. Chandrakumar AA, Coyaud É, Marshall CB, Ikura M, Raught B, Rottapel R
Structure of a mammalian sperm cation channel complex.
1. Nature - published July 5, 2021
2. Lin S, Ke M, Zhang Y, Yan Z, Wu J
In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission.
1. Elife - published July 5, 2021
2. Haugh KA, Ladinsky MS, Ullah I, Stone HM, Pi R, Gilardet A, Grunst MW, Kumar P, Bjorkman PJ, Mothes W, Uchil PD
Recombinant SARS-CoV-2 envelope protein traffics to the trans-Golgi network following amphipol-mediated delivery into human cells.
1. J Biol Chem - published July 5, 2021
2. Hutchison JM, Capone R, Luu DD, Shah KH, Hadziselimovic A, Van Horn WD, Sanders CR
The SARS-CoV-2 Programmed -1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA Crystallography.
1. ACS Chem Biol - published July 3, 2021
2. Roman C, Lewicka A, Koirala D, Li NS, Piccirilli JA
McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.
1. Elife - published July 3, 2021
2. Hajdusits B, Suskiewicz MJ, Hundt N, Meinhart A, Kurzbauer R, Leodolter J, Kukura P, Clausen T
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2.
1. Science - published July 3, 2021
2. Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, White KM, Zhang Z, Alon A, Schadt H, O'Donnell HR, Lyu J, Rosales R, McGovern BL, Rathnasinghe R, Jangra S, Schotsaert M, Galarneau JR, Krogan NJ, Urban L, Shokat KM, Kruse AC, García-Sastre A, Schwartz O, Moretti F, Vignuzzi M, Pognan F, Shoichet BK
A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection.
1. Nat Commun - published July 3, 2021
2. Li T, Cai H, Yao H, Zhou B, Zhang N, van Vlissingen MF, Kuiken T, Han W, GeurtsvanKessel CH, Gong Y, Zhao Y, Shen Q, Qin W, Tian XX, Peng C, Lai Y, Wang Y, Hutter CAJ, Kuo SM, Bao J, Liu C, Wang Y, Richard AS, Raoul H, Lan J, Seeger MA, Cong Y, Rockx B, Wong G, Bi Y, Lavillette D, Li D
Translational autoregulation of the S. cerevisiae high-affinity polyamine transporter Hol1.
1. Mol Cell - published July 3, 2021
2. Vindu A, Shin BS, Choi K, Christenson ET, Ivanov IP, Cao C, Banerjee A, Dever TE
Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom.
1. ACS Chem Neurosci - published July 2, 2021
2. Chakraborty S, Uprety R, Daibani AE, Rouzic VL, Hunkele A, Appourchaux K, Eans SO, Nuthikattu N, Jilakara R, Thammavong L, Pasternak GW, Pan YX, McLaughlin JP, Che T, Majumdar S
Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses.
1. Front Immunol - published July 2, 2021
2. Bullen G, Galson JD, Hall G, Villar P, Moreels L, Ledsgaard L, Mattiuzzo G, Bentley EM, Masters EW, Tang D, Millett S, Tongue D, Brown R, Diamantopoulos I, Parthiban K, Tebbutt C, Leah R, Chaitanya K, Ergueta-Carballo S, Pazeraitis D, Surade SB, Ashiru O, Crippa L, Cowan R, Bowler MW, Campbell JI, Lee WJ, Carr MD, Matthews D, Pfeffer P, Hufton SE, Sawmynaden K, Osbourn J, McCafferty J, Karatt-Vellatt A
Site-Specific Steric Control of SARS-CoV-2 Spike Glycosylation.
1. Biochemistry - published July 2, 2021
2. Allen JD, Chawla H, Samsudin F, Zuzic L, Shivgan AT, Watanabe Y, He WT, Callaghan S, Song G, Yong P, Brouwer PJM, Song Y, Cai Y, Duyvesteyn HME, Malinauskas T, Kint J, Pino P, Wurm MJ, Frank M, Chen B, Stuart DI, Sanders RW, Andrabi R, Burton DR, Li S, Bond PJ, Crispin M
Large-conductance calcium-activated K⁺ channels, rather than K_ATP channels, mediate the inhibitory effects of nitric oxide on mouse lymphatic pumping.
1. Br J Pharmacol - published July 2, 2021
2. Kim HJ, Li M, Nichols CG, Davis MJ
Validation and classification of RNA binding proteins identified by mRNA interactome capture.
1. RNA - published July 2, 2021
2. Vaishali V, Dimitrova-Paternoga L, Haubrich K, Sun M, Ephrussi A, Hennig J
Mechanisms underlying genetic susceptibility to Multisystem Inflammatory Syndrome in Children (MIS-C).
1. J Allergy Clin Immunol - published July 2, 2021
2. Chou J, Platt CD, Habiballah S, Nguyen AA, Elkins M, Weeks S, Peters Z, Day-Lewis M, Novak T, Armant M, Williams L, Rockowitz S, Sliz P, Williams DA, Randolph AG, Geha RS, Taking on COVID-19 Together Study Investigators., Almutairi A, Jaber F, Banzon T, Roberts J, Halyabar O, Lo M, Kahn S, Henderson LA, Lee PY, Son MB, Cheng L
Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology.
1. J Biol Chem - published July 2, 2021
2. Amaya C, Cameron CJ, Devarkar SC, Seager SJ, Gerstein MB, Xiong Y, Schlieker C
Sorting of cadherin-catenin-associated proteins into individual clusters.
1. Proc Natl Acad Sci U S A - published July 2, 2021
2. Troyanovsky RB, Sergeeva AP, Indra I, Chen CS, Kato R, Shapiro L, Honig B, Troyanovsky SM
Author Correction: Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs.
1. Nat Struct Mol Biol - published July 2, 2021
2. Kern DM, Sorum B, Mali SS, Hoel CM, Sridharan S, Remis JP, Toso DB, Kotecha A, Bautista DM, Brohawn SG
A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.
1. Sci Transl Med - published July 2, 2021
2. Boudreau MW, Duraki D, Wang L, Mao C, Kim JE, Henn MA, Tang B, Fanning SW, Kiefer J, Tarasow TM, Bruckheimer EM, Moreno R, Mousses S, Greene GL, Roy EJ, Park BH, Fan TM, Nelson ER, Hergenrother PJ, Shapiro DJ
AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms.
1. Blood - published July 2, 2021
2. Morande PE, Yan XJ, Sepulveda J, Seija N, Marquez ME, Sotelo N, Abreu C, Crispo M, Fernández-Graña G, Rego N, Bois T, Methot SP, Palacios F, Remedi V, Rai KR, Buschiazzo A, Di Noia JM, Navarrete MA, Chiorazzi N, Oppezzo P
Correlated Motions in Structural Biology.
1. Biochemistry - published July 2, 2021
2. Xu D, Meisburger SP, Ando N
Ongoing global and regional adaptive evolution of SARS-CoV-2.
1. Proc Natl Acad Sci U S A - published July 2, 2021
2. Rochman ND, Wolf YI, Faure G, Mutz P, Zhang F, Koonin EV
Purification of MBP fusion proteins using engineered DARPin affinity matrix.
1. Int J Biol Macromol - published July 2, 2021
2. Nemergut M, Škrabana R, Berta M, Plückthun A, Sedlák E
Mitochondrial damage in renal epithelial cells is potentiated by protein exposure in propionic aciduria.
1. J Inherit Metab Dis - published July 2, 2021
2. Schumann A, Belche V, Schaller K, Grünert SC, Kaech A, Baumgartner MR, Kölker S, Hannibal L, Spiekerkoetter U
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.
1. Nat Chem Biol - published July 2, 2021
2. Grabarczyk DB, Petrova OA, Deszcz L, Kurzbauer R, Murphy P, Ahel J, Vogel A, Gogova R, Faas V, Kordic D, Schleiffer A, Meinhart A, Imre R, Lehner A, Neuhold J, Bader G, Stolt-Bergner P, Böttcher J, Wolkerstorfer B, Fischer G, Grishkovskaya I, Haselbach D, Kessler D, Clausen T
Structure and function of an Arabidopsis thaliana sulfate transporter.
1. Nat Commun - published July 2, 2021
2. Wang L, Chen K, Zhou M
Lentiviral-driven discovery of cancer drug resistance mutations.
1. Cancer Res - published July 2, 2021
2. Yenerall P, Kollipara RK, Avila K, Peyton M, Eide CA, Bottomly D, McWeeney SK, Liu Y, Westover KD, Druker BJ, Minna JD, Kittler R
Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling.
1. Eur J Pharm Biopharm - published July 2, 2021
2. Merten H, Brandl F, Zimmermann M, Schaefer JV, Irpinio L, M K Sand K, Nilsen J, Andersen JT, Zangemeister-Wittke U, Plückthun A
Induced proximity tools for precise manipulation of lipid signaling.
1. Curr Opin Chem Biol - published July 2, 2021
2. Tei R, Baskin JM
Breakers and amplifiers in chromatin circuitry: acetylation and ubiquitination control the heterochromatin machinery.
1. Curr Opin Struct Biol - published July 2, 2021
2. Bailey LT, Northall SJ, Schalch T
Electron paramagnetic resonance spectroscopy on G-protein-coupled receptors: Adopting strategies from related model systems.
1. Curr Opin Struct Biol - published July 2, 2021
2. Reichenwallner J, Liu B, Balo AR, Ou WL, Ernst OP
O-Linked-N-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics.
1. J Am Chem Soc - published July 2, 2021
2. Nosella ML, Tereshchenko M, Pritišanac I, Chong PA, Toretsky JA, Lee HO, Forman-Kay JD
Quorum sensing governs a transmissive Legionella subpopulation at the pathogen vacuole periphery.
1. EMBO Rep - published July 2, 2021
2. Striednig B, Lanner U, Niggli S, Katic A, Vormittag S, Brülisauer S, Hochstrasser R, Kaech A, Welin A, Flieger A, Ziegler U, Schmidt A, Hilbi H, Personnic N
Insane in the membrane: developments in protein folding, protein transport, and signaling by GPCRs.
1. Curr Opin Struct Biol - published July 2, 2021
2. Maher MJ, Ernst OP
Cryo-EM structure of human Wntless in complex with Wnt3a.
1. Nat Commun - published July 2, 2021
2. Zhong Q, Zhao Y, Ye F, Xiao Z, Huang G, Xu M, Zhang Y, Zhan X, Sun K, Wang Z, Cheng S, Feng S, Zhao X, Zhang J, Lu P, Xu W, Zhou Q, Ma D
Structure and analysis of nanobody binding to the human ASIC1a ion channel.
1. Elife - published July 2, 2021
2. Wu Y, Chen Z, Sigworth FJ, Canessa CM
Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody.
1. Biochemistry - published July 2, 2021
2. Eriksen J, Li F, Stroud RM, Edwards RH
Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates.
1. Sci Transl Med - published July 2, 2021
2. Francica JR, Flynn BJ, Foulds KE, Noe AT, Werner AP, Moore IN, Gagne M, Johnston TS, Tucker C, Davis RL, Flach B, O'Connell S, Andrew SF, Lamb E, Flebbe DR, Nurmukhambetova ST, Donaldson MM, Todd JM, Zhu AL, Atyeo C, Fischinger S, Gorman MJ, Shin S, Edara VV, Floyd K, Lai L, Boyoglu-Barnum S, Van De Wetering R, Taylor A, McCarthy E, Lecouturier V, Ruiz S, Berry C, Tibbitts T, Andersen H, Cook A, Dodson A, Pessaint L, Van Ry A, Koutsoukos M, Gutzeit C, Teng IT, Zhou T, Li D, Haynes BF, Kwong PD, McDermott A, Lewis MG, Fu TM, Chicz R, van der Most R, Corbett KS, Suthar MS, Alter G, Roederer M, Sullivan NJ, Douek DC, Graham BS, Casimiro D, Seder RA
A plug-and-play platform of ratiometric bioluminescent sensors for homogeneous immunoassays.
1. Nat Commun - published July 2, 2021
2. Ni Y, Rosier BJHM, van Aalen EA, Hanckmann ETL, Biewenga L, Pistikou AM, Timmermans B, Vu C, Roos S, Arts R, Li W, de Greef TFA, van Borren MMGJ, van Kuppeveld FJM, Bosch BJ, Merkx M
Probing the transport of Ni(II) ions through the internal tunnels of the Helicobacter pylori UreDFG multimeric protein complex.
1. J Inorg Biochem - published July 2, 2021
2. Masetti M, Bertazzo M, Recanatini M, Ciurli S, Musiani F
Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy.
1. Elife - published July 2, 2021
2. Weber MS, Eibauer M, Sivagurunathan S, Magin TM, Goldman RD, Medalia O
Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity.
1. Nat Commun - published July 2, 2021
2. Zhang Y, Brown K, Yu Y, Ibrahim Z, Zandian M, Xuan H, Ingersoll S, Lee T, Ebmeier CC, Liu J, Panne D, Shi X, Ren X, Kutateladze TG
TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma.
1. Cancer Cell - published July 2, 2021
2. Seong BKA, Dharia NV, Lin S, Donovan KA, Chong S, Robichaud A, Conway A, Hamze A, Ross L, Alexe G, Adane B, Nabet B, Ferguson FM, Stolte B, Wang EJ, Sun J, Darzacq X, Piccioni F, Gray NS, Fischer ES, Stegmaier K
Assessing the filtration efficiency and regulatory status of N95s and nontraditional filtering face-piece respirators available during the COVID-19 pandemic.
1. BMC Infect Dis - published July 2, 2021
2. Plana D, Tian E, Cramer AK, Yang H, Carmack MM, Sinha MS, Bourgeois FT, Yu SH, Masse P, Boyer J, Kim M, Mo J, LeBoeuf NR, Li J, Sorger PK
Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations.
1. J Mol Biol - published July 2, 2021
2. Miersch S, Li Z, Saberianfar R, Ustav M, Brett Case J, Blazer L, Chen C, Ye W, Pavlenco A, Gorelik M, Garcia Perez J, Subramania S, Singh S, Ploder L, Ganaie S, Chen RE, Leung DW, Pandolfi PP, Novelli G, Matusali G, Colavita F, Capobianchi MR, Jain S, Gupta JB, Amarasinghe GK, Diamond MS, Rini J, Sidhu SS
Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.
1. Immunity - published July 2, 2021
2. Muecksch F, Weisblum Y, Barnes CO, Schmidt F, Schaefer-Babajew D, Wang Z, C Lorenzi JC, Flyak AI, DeLaitsch AT, Huey-Tubman KE, Hou S, Schiffer CA, Gaebler C, Da Silva J, Poston D, Finkin S, Cho A, Cipolla M, Oliveira TY, Millard KG, Ramos V, Gazumyan A, Rutkowska M, Caskey M, Nussenzweig MC, Bjorkman PJ, Hatziioannou T, Bieniasz PD
Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike.
1. Cell - published July 2, 2021
2. Tong P, Gautam A, Windsor IW, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Storm N, Malsick LE, Honko AN, Lelis FJN, Habibi S, Jenni S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR
Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer.
1. Bioorg Med Chem - published July 2, 2021
2. Yang X, Fan D, Troha AH, Ahn HM, Qian K, Liang B, Du Y, Fu H, Ivanov AA
A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope.
1. Cell Rep Med - published July 2, 2021
2. Raman S, Buongervino SN, Lane MV, Zhelev DV, Zhu Z, Cui H, Martinez B, Martinez D, Wang Y, Upton K, Patel K, Rathi KS, Navia CT, Harmon DB, Li Y, Pawel B, Dimitrov DS, Maris JM, Julien JP, Bosse KR
CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2.
1. ACS Cent Sci - published July 2, 2021
2. Amraei R, Yin W, Napoleon MA, Suder EL, Berrigan J, Zhao Q, Olejnik J, Chandler KB, Xia C, Feldman J, Hauser BM, Caradonna TM, Schmidt AG, Gummuluru S, Mühlberger E, Chitalia V, Costello CE, Rahimi N
Optical Control of Phosphatidic Acid Signaling.
1. ACS Cent Sci - published July 2, 2021
2. Tei R, Morstein J, Shemet A, Trauner D, Baskin JM
Assessment of shallow aquifer vulnerability to fluoride contamination using modified AHP-DRASTICH model as a tool for effective groundwater management, a case study in Yuncheng Basin, China.
1. Chemosphere - published July 2, 2021
2. Wang W, Mwiathi NF, Li C, Luo W, Zhang X, An Y, Zhang M, Gong P, Liu J, Gao X
METTL1-mediated m⁷G modification of Arg-TCT tRNA drives oncogenic transformation.
1. Mol Cell - published July 2, 2021
2. Orellana EA, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos DA, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes GJL, Fischer ES, Bradley A, Vassiliou GS, Slack FJ, Tzelepis K, Gregory RI
A Gel-Based Assay for Probing Protein Translocation on dsDNA.
1. Bio Protoc - published July 2, 2021
2. Brugger C, Deaconescu AM
Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus.
1. J Vis Exp - published July 2, 2021
2. Gao Y, Ogilvie C, Raghavan A, Von Hoffmann C, Liang B
Lipid Transporters Beam Signals from Cell Membranes.
1. Membranes (Basel) - published July 2, 2021
2. Ristovski M, Farhat D, Bancud SEM, Lee JY
PROGRESSION OF SCOTOPIC SINGLE-FLASH ELECTRORETINOGRAPHY IN THE STAGES OF CAPN5 VITREORETINOPATHY.
1. Retin Cases Brief Rep - published July 1, 2021
2. Tang PH, Kinnick TR, Folk JC, Mahajan M, Bassuk AG, Tsang SH, Mahajan VB
Targeted mutagenesis in human iPSCs using CRISPR genome-editing tools.
1. Methods - published July 1, 2021
2. Long Y, Cech TR
Body site distribution of pediatric-onset morphea and association with extracutaneous manifestations.
1. J Am Acad Dermatol - published July 1, 2021
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The Present and Future of Mitochondrial-Based Therapeutics for Eye Disease.
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Beyond PKA: Evolutionary and Structural Insights that Define a Docking and Dimerization Domain Superfamily.
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Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.
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1. Nat Struct Mol Biol - published July 1, 2021
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1. Nat Commun - published July 1, 2021
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1. NPJ Precis Oncol - published July 1, 2021
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Structural details of monoclonal antibody m971 recognition of the membrane-proximal domain of CD22.
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1. Nat Biomed Eng - published July 1, 2021
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Flexible microtubule anchoring modulates the bi-directional motility of the kinesin-5 Cin8.
1. Cell Mol Life Sci - published July 1, 2021
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Diversity, Equity, and Inclusion in The Journal of Pediatrics.
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Structure-Guided Design of a "Bump-and-Hole" Bromodomain-Based Degradation Tag.
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BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells.
1. Nat Immunol - published July 1, 2021
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Accurate prediction of protein structures and interactions using a three-track neural network.
1. Science - published July 1, 2021
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Drug discovery in the era of cryo-electron microscopy.
1. Trends Biochem Sci - published July 1, 2021
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An intranasal vaccine durably protects against SARS-CoV-2 variants in mice.
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Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells.
1. Mol Cell - published July 1, 2021
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Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress.
1. Res Pract Thromb Haemost - published July 1, 2021
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Reopening International Borders without Quarantine: Contact Tracing Integrated Policy against COVID-19.
1. Int J Environ Res Public Health - published July 1, 2021
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Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.
1. Adv Sci (Weinh) - published July 1, 2021
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Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
1. Mol Cell - published July 1, 2021
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Chemo-proteomics exploration of HDAC degradability by small molecule degraders.
1. Cell Chem Biol - published July 1, 2021
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Combined computational and cellular screening identifies synergistic inhibition of SARS-CoV-2 by lenvatinib and remdesivir.
1. J Gen Virol - published July 1, 2021
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Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens.
1. Diagnostics (Basel) - published July 1, 2021
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Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk.
1. Viruses - published July 1, 2021
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Two-distinct polymer ubiquitin conjugates by photochemical grafting-from.
1. Macromol Chem Phys - published July 1, 2021
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A data-driven architecture using natural language processing to improve phenotyping efficiency and accelerate genetic diagnoses of rare disorders.
1. HGG Adv - published July 1, 2021
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