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132 Member Publications for August

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Vaccination with Acinetobacter baumannii adhesin Abp2D provides protection against catheter-associated urinary tract infection.
1. Nat Commun - published August 9, 2025
2. Timm MR, Tamadonfar KO, Nye TM, Villicaña JB, Pinkner JS, Dodson KW, Ellebedy AH, Hultgren SJ
Structure and function of the human apoptotic scramblase Xkr4.
1. Nat Commun - published August 8, 2025
2. Chakraborty S, Feng Z, Lee S, Alvarenga OE, Panda A, Zhang S, Bruni R, Khelashvili G, Gupta K, Accardi A
Author Correction: An extensive disulfide bond network prevents tail contraction in Agrobacterium tumefaciens phage Milano.
1. Nat Commun - published August 7, 2025
2. Sonani RR, Palmer LK, Esteves NC, Horton AA, Sebastian AL, Kelly RJ, Wang F, Kreutzberger MAB, Russell WK, Leiman PG, Scharf BE, Egelman EH
Establishment of the phagophore-ERES membrane contact site initiates phagophore elongation.
1. Nat Struct Mol Biol - published August 7, 2025
2. Gómez-Sánchez R, Chumpen Ramirez S, Vargas Duarte P, Hu Y, Mari M, Olschewski K, Hardenberg R, Fromme JC, Ungermann C, Reggiori F
Impact of an Evidence-Based Large Language Model (LLM) Diagnostic Decision Support System: A Randomised Controlled Trial.
1. Stud Health Technol Inform - published August 7, 2025
2. Ahn S, Park J, Hur S, Jung KY, Lee JH, Choi SW, Son MH, Kang MJ, Kim YJ, Park H, Cha WC, Yoo J
Genomics-informed drug-repurposing strategy identifies two therapeutic targets for preventing liver disease associated with metabolic dysfunction.
1. Am J Hum Genet - published August 7, 2025
2. Seagle HM, Akerele AT, DeCorte JA, Hellwege JN, Breeyear JH, Kim J, Levin MG, Khodursky S, Bress A, Lee KM, Meiler J, Gill D, Lee JS, Heberer K, Miller DR, Reaven PD, Chang KM, Lynch JA, VA Million Veteran Program, Khankari NK, Shuey MM, Edwards TL, Vujkovic M
Dynamic intraligand binding reveals a new function for PDZ domains.
1. Structure - published August 7, 2025
2. Fuentes EJ
Principles of cotranslational mitochondrial protein import.
1. Cell - published August 7, 2025
2. Zhu Z, Mallik S, Stevens TA, Huang R, Levy ED, Shan SO
Structure of the TXNL1-bound proteasome.
1. Nat Struct Mol Biol - published August 6, 2025
2. Gao J, Nardone C, Yip MCJ, Chino H, Gu X, Mirman Z, Rale MJ, Paulo JA, Elledge SJ, Shao S
Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope.
1. Cell Rep - published August 6, 2025
2. Rao VN, Sapse IA, Cohn H, Yoo DK, Tong P, Clark JJ, Bozarth B, Chen Y, Srivastava K, Singh G, Krammer F, Simon V, Wesemann DR, Bajic G, Coelho CH
The N terminus of H3-influenza hemagglutinin as a site-of-vulnerability to neutralizing antibody.
1. Structure - published August 6, 2025
2. Rawi R, Morano NC, Cheung CS, Du H, Gorman J, Prabhakaran M, Becker JE, Bylund T, Charaf S, Chen X, Lee M, Harris DR, Olia AS, Ou L, Wang L, Wang S, Zhang B, Kanekiyo M, McDermott AB, Zhou T, Shapiro L, Kwong PD
Surface delivery quantification reveals distinct trafficking efficiencies among clustered protocadherin isoforms.
1. Proc Natl Acad Sci U S A - published August 5, 2025
2. May EJ, Gaudet R
Cytosolic- and membrane-localized oxidized indole-3-acetic acid formation regulates developmental auxin transients.
1. Plant Physiol - published August 5, 2025
2. Jenness M, Tayengwa R, House L, Cao S, Báez RR, Nath S, Pritchard CA, Sharma A, Mergner J, Rivière F, Meinnel T, Giglione C, Kuster B, Blakeslee JJ, Nemhauser JL, Zheng N, Murphy AS, Peer WA
Identification and characterization of nanobodies specific for the human ubiquitin-like ISG15 protein.
1. J Biol Chem - published August 5, 2025
2. Gan J, Dabhade P, Wijne C, McKibben W, Draganov SD, Alrawili H, Jim Sun ZY, Houghton JW, Tate EW, Le Gall C, Suresh P, Pishesha N, Pinto-Fernández A, Schwartz TU, Ploegh HL
A rapid and highly sensitive CRISPR assay utilizing Cas12a orthologs for the detection of Novel Duck Reovirus.
1. Talanta - published August 5, 2025
2. Wang Y, Fu L, Li S, Tao D, Gong P, Yang Y, Ruan J, Xie S, Wang C, He D
Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways.
1. Structure - published August 5, 2025
2. Barghash MM, Mabanglo MF, Hoff SE, Brozdnychenko D, Wong KS, Binepal G, Ip P, Shen J, Furukawa T, Katayama H, Trudel V, Tan J, Yudin AK, Gray-Owen SD, Sakuda S, Batey RA, Vahidi S, Bonomi M, Houry WA
Structure of the microtubule-anchoring factor NEDD1 bound to the γ-tubulin ring complex.
1. J Cell Biol - published August 4, 2025
2. Muñoz-Hernández H, Xu Y, Pellicer Camardiel A, Zhang D, Xue A, Aher A, Walker E, Marxer F, Kapoor TM, Wieczorek M
A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores.
1. J Cell Biol - published August 4, 2025
2. Stewart MG, Carrier JS, Zahm JA, Harrison SC, Miller MP
The rapidly expanding role of LC3-interacting regions in autophagy.
1. J Cell Biol - published August 4, 2025
2. North BJ, Fracchiolla D, Ragusa MJ, Martens S, Shoemaker CJ
SMAC mimetics induce human macrophages to phagocytose live cancer cells.
1. Immunother Adv - published August 4, 2025
2. Liu SY, Hulsman MPM, Leyendecker P, Chang E, Donovan KA, Strobel F, Dougan J, Fischer ES, Dougan M, Dougan SK, Qiang L
Real-time capture of σ(N) transcription initiation intermediates reveals mechanism of ATPase-driven activation by limited unfolding.
1. Nat Commun - published August 4, 2025
2. Mueller AU, Molina N, Nixon BT, Darst SA
Development of a novel therapy for systolic heart failure.
1. EMBO Mol Med - published August 4, 2025
2. Pollock C, Wang X, Alsaraji H, Menassa J, Mbogo G, Angage D, Richards B, Glab J, Datta KK, Theodoridis L, Petrovski S, Donner D, Lizarme-Salas Y, Du XJ, Foley M, Smith BJ, Abbott B, Puthalakath H
Identification of Aspartyl-tRNA Synthetase as Co-purifying with Wheat Germ eIF2.
1. MicroPubl Biol - published August 4, 2025
2. Papoulas O, Marcotte EM, Browning KS
The TTLL10 polyglycylase is stimulated by tubulin glutamylation and inhibited by polyglycylation.
1. bioRxiv - published August 4, 2025
2. Cummings SW, Li Y, Spector JO, Kim C, Roll-Mecak A
Functional dissection of Wag31 domains for septal recruitment and polar distribution during the cell cycle.
1. bioRxiv - published August 2, 2025
2. Petit J, Megrian D, Martinez M, Sogues A, de Sousa-d'Auria C, Assaya MB, Thouvenot C, Lesur E, Bourdreux Y, Bayan N, Alzari PM, Wehenkel AM
Functional diversity of phage sponge proteins that sequester host immune signals.
1. bioRxiv - published August 2, 2025
2. Hadary R, Chang RB, Béchon N, Tal N, Osterman I, Yirmiya E, Garb J, Amitai G, Kranzusch PJ, Sorek R
α-catenin phosphorylation is actomyosin-sensitive and required for epithelial barrier functions through Afadin.
1. bioRxiv - published August 2, 2025
2. Quinn JM, Le PM, Weng A, Flozak AS, Folmsbee SS, Arroyo-Colon E, Ikura M, Ishiyama N, Gottardi CJ
12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII.
1. Nat Commun - published August 2, 2025
2. Nirengi S, Buck B, Das D, Peres Valgas da Silva C, Calyeca J, Baer LA, Huang HL, Vidal P, Dewal RS, Pinckard KM, Félix-Soriano E, Hernandez-Saavedra D, Gerea A, Dathathreya K, Duarte-Sanmiguel S, Saldana TA, Hookfin HL, Gorr MW, Bussberg V, Aristizabal-Henao JJ, Kiebish MA, Middelbeek RJW, Goodyear LJ, Coen PM, Chinthalapudi K, Wold LE, Mora AL, Hund TJ, Gallego-Perez D, Stanford KI
Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration.
1. Nat Commun - published August 2, 2025
2. Lv G, Sayles NM, Huang Y, Mancinelli C, McAvoy K, Shneider NA, Manfredi G, Kawamata H, Eliezer D
Modeling protein conformational ensembles by guiding AlphaFold2 with Double Electron Electron Resonance (DEER) distance distributions.
1. Nat Commun - published August 2, 2025
2. Wu T, Stein RA, Kao TY, Brown B, Mchaourab HS
Clostridioides difficile toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity.
1. bioRxiv - published August 2, 2025
2. Maslanka JR, Londregan JA, Denny JE, Hulit EN, Mdluli NV, Peritore-Galve FC, Alam MZ, Alameh MG, Lacy DB, Zackular JP, Abt MC
Cryo-EM structure of the Seneca Valley virus A-particle and related structural states.
1. J Virol - published August 2, 2025
2. Kumaran R, Jayawardena N, Chen K-L, Eruera A-R, Hodgkinson-Bean J, Burga LN, Wolf M, Bostina M
Impact of Protein Conformational Diversity on Structure-Based Prediction of Druggability.
1. J Chem Inf Model - published August 2, 2025
2. Bekar-Cesaretli AA, Vats S, Whitty A, Kozakov D, Joseph-McCarthy D, Vajda S
An Amyloidogenic Fragment of the Spike Protein from SARS-CoV-2 Virus Stimulates the Aggregation and Toxicity of Parkinson's Disease Protein Alpha-Synuclein.
1. ACS Chem Neurosci - published August 2, 2025
2. Gemignani JF, Netz PA, Izecksohn D, Dabkiewicz D, Li MH, Wiecikowski AF, Eliezer D, Cordeiro Y, Follmer C
The HIV-1 nuclear export complex reveals the role of RNA in CRM1 cargo recognition.
1. Mol Cell - published August 2, 2025
2. Smith AM, Li Y, Velarde A, Cheng Y, Frankel AD
Mouse monoclonal antibodies against Clostridioides difficile toxins TcdA and TcdB target diverse epitopes for neutralization.
1. Infect Immun - published August 2, 2025
2. Kroh HK, Jensen JL, Wellnitz S, Park JJ, Esadze A, Huynh KW, Ammirati M, Han S, Anderson AS, Lacy DB, Gribenko A
A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense.
1. Mol Cell - published August 2, 2025
2. Chang RB, Toyoda HC, Hobbs SJ, Hadary R, Richmond-Buccola D, Wein T, Osterman I, Burger N, Chouchani ET, Sorek R, Kranzusch PJ
Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation.
1. Mol Cell - published August 2, 2025
2. Słabicki M, Park J, Nowak RP, Roy Burman SS, Pellman J, Zou C, Razumkov H, Carreiro J, Rastogi S, Goldstein A, Nagiec MM, Donovan KA, Che J, Hunkeler M, Geng Q, Hsu CL, Lakshminarayan M, Shu C, Zon RL, Kozicka Z, Park PMC, Tsai JM, Yoon H, Jones LH, Sperling AS, Gray NS, Fischer ES, Ebert BL
Exchangeable APOA1 on High-density Lipoprotein Inhibits Low-Density Lipoprotein Binding to Proteoglycans.
1. J Lipid Res - published August 2, 2025
2. Geh EN, Swertfeger DK, Roscoe I, Street SE, Alexiana B, Sexmith H, Woollett LA, Davidson WS, Shah AS
Visualizing dynamic tubulin folding in chaperonin TRiC from nonnative nucleus to final native state.
1. Nat Commun - published August 2, 2025
2. Zhao Y, Schmid MF, Chiu W
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults.
1. Nat Commun - published August 2, 2025
2. Cohen CA, Grzelak L, Chiu SS, Hui DS, Kwan MY, Tsang OT, Chan WH, Yau YS, Lee KW, Mori M, Amarasinghe GK, Cheng SM, Poon LL, Peiris M, Valkenburg SA
A scaffold for quinone channeling between membrane and soluble bacterial oxidoreductases.
1. Nat Struct Mol Biol - published August 2, 2025
2. Broc M, Cherrier MV, Uzel A, Arias-Cartin R, Arnoux P, Brasseur G, Seduk F, Guigliarelli B, Legrand P, Pierrel F, Schoehn G, Maté MJ, Martin L, Grimaldi S, Nicolet Y, Magalon A, Walburger A
Molecular Basis for the Activation of Pseudomonas aeruginosa MsbA by Divalent Metals.
1. J Am Chem Soc - published August 2, 2025
2. Lyu J, Bahramimoghaddam H, Zhang T, Scott E, Yun SD, Yadav GP, Zhao M, Russell D, Laganowsky A
A realistic phantom dataset for benchmarking cryo-ET data annotation.
1. Nat Methods - published August 2, 2025
2. Peck A, Yu Y, Schwartz J, Cheng A, Ermel UH, Hutchings J, Kandel S, Kimanius D, Montabana EA, Serwas D, Siems H, Wang F, Zhao Z, Zheng S, Haury M, Agard DA, Potter CS, Carragher B, Harrington K, Paraan M
Atomic Resolution Interactions Regulating Partitioning of a FUS Folded RRM Domain into Model CAPRIN1 Condensates.
1. J Am Chem Soc - published August 2, 2025
2. Ahmed R, Bonin JP, Forman-Kay JD, Kay LE
AuxB interacts directly with GpsB and PknB to coordinate cell envelope processes that contribute to intrinsic antibiotic resistance in Staphylococcus aureus.
1. mBio - published August 2, 2025
2. Sisley TA, Park Y, Santiago AG, Beroual W, Sobolewski IA, Lee W, Paulo JA, Walker S
A structural window into the evolution of secondary transport mechanisms.
1. Nat Struct Mol Biol - published August 2, 2025
2. Berry SP, Gaudet R
Identification of asporin as a HER3 ligand exposes a therapeutic vulnerability in prostate cancer.
1. JCI Insight - published August 2, 2025
2. Hesterberg AB, Wong HY, Jackson J, Antunovic M, Rios BL, Watkins E, Bergman RE, Davidson BA, Ginther SE, Graves D, Nahmias EF, Googel JA, Martin LB, Sanchez V, Gonzalez-Ericsson PI, Sheng Q, Brown BP, Meiler J, Schaffer KR, Gordetsky JB, Park BH, Hurley PJ
Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters.
1. Nat Struct Mol Biol - published August 2, 2025
2. Reddy KD, Rasool B, Akher FB, Kutlešić N, Pant S, Boudker O
Improved Pharmacokinetic Profiles of HDAC6 Inhibitors via Cap Group Modifications.
1. J Med Chem - published August 2, 2025
2. Olaoye OO, Erdogan F, Gracia-Hernandez M, Garcha HK, Sedighi A, Ashraf QF, Nawar N, Geletu M, Seo HS, Abdallah DI, Abdeldayem A, Hassan MM, Dhe-Paganon S, de Araujo ED, Villagra A, Gunning PT
Disrupting Amyloid Filaments of Tau by Means of Electric Fields.
1. J Phys Chem B - published August 2, 2025
2. Vargas-Rosales PA, Giangreco G, Caflisch A
Antibody cross-reactivity among alphaviruses clinical practice.
1. Trends Microbiol - published August 2, 2025
2. Hatami J, de Bruin ACM, Bánki Z, Rey FA, Gerold G
Discovery of YTHDF2 Ligands by Fragment-Based Design.
1. ACS Bio Med Chem Au - published August 2, 2025
2. Invernizzi A, Nai F, Bedi RK, Vargas-Rosales PA, Li Y, Bochenkova E, Herok M, Zálešák F, Caflisch A
Basis for selective drug evasion of an aminoglycoside-resistance ribosomal RNA modification.
1. Nat Commun - published August 2, 2025
2. Dey D, Mattingly JM, Zelinskaya N, Dunham CM, Conn GL
Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation.
1. Sci Transl Med - published August 2, 2025
2. Sharma S, Prathigudupu V, Cable C, Serrano LR, Nerella S, Chen A, Hassan G, Lakins J, Valenzuela CL, Tsukui T, Ramamoorthi R, Kim JJ, Willenbring H, Mattis AN, Volk RF, Zaro BW, Coon JJ, Beresis R, DeGrado WF, Weaver VM, Christenson SA, Jo H, Chen JY
Structural basis for lipid transport at membrane contact sites by the IST2-OSH6 complex.
1. Nat Struct Mol Biol - published August 2, 2025
2. Arndt M, Schweri A, Dutzler R
Human monoclonal antibodies targeting A35 protect from death caused by mpox.
1. Cell - published August 2, 2025
2. Fantin RF, Yuan M, Park SC, Bozarth B, Cohn H, Ignacio M, Earl P, Civljak A, Laghlali G, Zhang D, Zhu X, Crandell J, Monteiro V, Clark JJ, Cotter C, Burkhardt M, Singh G, Warang P, García-Bernalt Diego J, Srivastava K, Lugo LA, Pischel L, PVI study group, Yildirim I, Omer SB, da Silva D, Krammer F, Bajic G, Simon V, Schotsaert M, Lucas C, Wilson IA, Moss B, Coelho CH
Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control.
1. Science - published August 2, 2025
2. Grabarczyk DB, Ehrmann JF, Murphy P, Yang WS, Kurzbauer R, Bell LE, Deszcz L, Neuhold J, Schleiffer A, Shulkina A, Lee J, Shin JS, Meinhart A, Versteeg GA, Zavodszky E, Song HK, Hegde RS, Clausen T
Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation.
1. Cell - published August 2, 2025
2. Luo J, Khandwala S, Hu J, Lee SY, Hickey KL, Levine ZG, Harper JW, Ting AY, Weissman JS
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles.
1. Cell - published August 2, 2025
2. Grabarczyk DB, Aird EJ, Reznikow V, Kirchgatterer PC, Ehrmann JF, Kurzbauer R, Bell LE, Kellner MJ, Aggarwal R, Schleiffer A, Faas V, Deszcz L, Meinhart A, Versteeg GA, Penninger JM, Stelzl LS, Gaidt MM, Tessmer I, Corn JE, Clausen T
Structural basis of VCP-VCPIP1-p47 ternary complex in Golgi maintenance.
1. Nat Commun - published August 2, 2025
2. Shah B, Hunkeler M, Bratt A, Yue H, Jaen Maisonet I, Fischer ES, Buhrlage SJ
Molecular insights into the comorbidity of vitamin K-dependent clotting factor deficiency and chondrodysplasia punctata.
1. J Thromb Haemost - published August 2, 2025
2. Jin DY, Chen X, Wang M, Qi X, Stafford DW, Lewis S, Weiss MJ, Reiss UM, Tie JK
Production of Homogeneous, Functional Zinc-Finger Arrays in High Yield With Two Chromatographic Steps.
1. Bio Protoc - published August 2, 2025
2. Liang J, Azubel M, Wang G, Nie Y, Kornberg RD, Beel AJ, Matteï PJ
Dendrobium officinale Kimura et Migo: traditional uses, agricultural technology, processing, chemical composition, pharmacological mechanisms, toxicology, and applications.
1. J Pharm Pharmacol - published August 2, 2025
2. Liu X, Wu J, Zhao B, Wen L, Liang C, Sun Z, Luo J, Li X
Characterizing Stroke Clots Using Single-Cell Sequencing.
1. J Am Heart Assoc - published August 2, 2025
2. Renedo D, Barak T, DeLong J, Acosta JN, Sujijantarat N, Koo A, Rivier CA, Clocchiatti-Tuozzo S, Huo S, Antonios J, Giles J, Falcone GJ, Sheth KN, Hebert R, Gunel M, Sansing LH, Navaratnam DS, Matouk C
First-generation N-terminal domain supersite public antibodies retain activity against Omicron-derived lineages and protect mice against Omicron BA.5 challenge.
1. mBio - published August 2, 2025
2. Dussupt V, Jensen JL, Thomas PV, Mendez-Rivera L, Lal KG, Zemil McCrea M, Swafford I, Hernandez J, Sankhala RS, Rao M, Arora J, Hajduczki A, Jian N, Rees PA, Showell-De Leon I, Smith G, Smith L, Wasson D, Schmid A, Teng I-T, Zhou T, Kwong PD, Currier JR, Reiley WW, Paquin-Proulx D, Polonis VR, Collins ND, Michael NL, Joyce MG, Krebs SJ
A family of tubular pili from harmful algal bloom forming cyanobacterium Microcystis aeruginosa.
1. Nat Commun - published August 2, 2025
2. Ricca JG, Petersen HA, Grosvirt-Dramen A, Mayali X, Naylon SH, Duersch BG, Dufresne CP, Weber PK, Sonani RR, Prevelige PE, Hochbaum AI, Merk V, Louda JW, Wang F
Peptidic Tryptophan Halogenation by a Promiscuous Flavin-Dependent Enzyme.
1. Angew Chem Int Ed Engl - published August 2, 2025
2. Rice AJ, Gadgil MG, Bisignano P, Stein RA, Mchaourab HS, Mitchell DA
Nucleotide-dependent conformational changes direct peptide export by the transporter associated with antigen processing.
1. Immunity - published August 2, 2025
2. Lee J, Manon V, Chen J
A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis.
1. Arthritis Rheumatol - published August 2, 2025
2. Deane KD, Striebich CC, Feser ML, O'Dell JR, James JA, Sparks JA, Davis JM, Graf J, McMahon MA, Solow EB, Forbess L, Tiliakos A, Schiopu E, Danila MI, Horowitz DL, Kay J, Strickland CD, Guthridge JM, Arriens C, Grossman JM, Demoruelle MK, Bemis EA, Frazer-Abel A, Fleischer CL, Fox DA, Mikuls TR, Greenleaf M, York K, Walker S, Keyes-Elstein L, Byron M, Fedler J, Goldmuntz EA, Holers VM
Characterization and inhibitor sensitivity of ARAF, BRAF, and CRAF complexes.
1. bioRxiv - published August 1, 2025
2. Tkacik E, Jang DM, Boxer K, Ha BH, Eck MJ
PDB-IHM: A System for Deposition, Curation, Validation, and Dissemination of Integrative Structures.
1. J Mol Biol - published August 1, 2025
2. Vallat B, Webb BM, Zalevsky A, Tangmunarunkit H, Sekharan MR, Voinea S, Shafaeibejestan A, Sagendorf J, Hoch JC, Kurisu G, Morris KL, Velankar S, Kesselman C, Burley SK, Berman HM, Sali A
Protein Data Bank Japan: Computational Resources for Analysis of Protein Structures.
1. J Mol Biol - published August 1, 2025
2. Bekker GJ, Nagao C, Shirota M, Nakamura T, Katayama T, Kihara D, Kinoshita K, Kurisu G
An intrinsically disordered region of Ubp10 regulates its binding and activity on ubiquitinated histone substrates.
1. Protein Sci - published August 1, 2025
2. Faustino AM, Nune M, Merino-Urteaga R, Manriquez-Sandoval E, Poyton M, Ha T, Wolberger C, Fried SD
E-FTMap: A Protein Structure Based Pharmacophore Identification Server for Guiding Fragment Expansion.
1. J Mol Biol - published August 1, 2025
2. Khan O, Jones G, Kozakov D, Beglov D, Joseph-McCarthy D, Vajda S
Glia-derived noncanonical fatty acid binding protein modulates brain lipid storage and clearance.
1. Sci Adv - published August 1, 2025
2. Yin J, Chen HL, Grigsby-Brown A, He Y, Cotten ML, Short J, Dermady A, Lei J, Gibbs M, Cheng ES, Zhang D, Long C, Tabet J, Xu L, Zhong T, Abzalimov R, Haider M, Sun R, He Y, Zhou Q, Tjandra N, Yuan Q
A pan-respiratory virus attachment inhibitor with high potency in human airway models and in vivo.
1. Sci Adv - published August 1, 2025
2. Mathez G, Silva PJ, Carlen V, Deloizy C, Prompt C, Hubart A, Rocha-Pereira J, Galloux M, Le Goffic R, Stellacci F, Cagno V
TOX, through a glass, darkly.
1. Front Immunol - published August 1, 2025
2. Hogan PG, Villalobos Reveles B, Arteaga Vazquez LJ
The molecular basis of lamin-specific chromatin interactions.
1. Nat Struct Mol Biol - published August 1, 2025
2. Wang B, Kronenberg-Tenga R, Rosti V, Di Patrizio Soldateschi E, Luo Q, Iannacchero UM, Pinet L, Eibauer M, Boujemaa-Paterski R, Schuler B, Lanzuolo C, Medalia O
Structure Modeling Protocols for Protein Multimer and RNA in CASP16 With Enhanced MSAs, Model Ranking, and Deep Learning.
1. Proteins - published August 1, 2025
2. Kagaya Y, Nakamura T, Verburgt J, Jain A, Terashi G, Punuru P, Tugolukova E, Park JH, Saha A, Huang D, Kihara D
Structure of CFTR bound to (R)-BPO-27 unveils a pore-blockage mechanism.
1. Nat Commun - published August 1, 2025
2. Young PG, Fiedorczuk K, Chen J
Identification of the seven critical residues that control ZIKV-DENV cross-reactivity to engineer a non-cross-reactive ZIKV vaccine.
1. Cell Rep - published August 1, 2025
2. Grinyo-Escuer A, Reddy S, Chenine AL, Whitbeck JC, Jacobsen S, Sheetz A, Doolan K, Norden DM, Frey N, Holtsberg FW, Aman MJ, Fink K, Diamond MS, Schieffelin JS, Crowe JE Jr, Davidson E, Doranz BJ
Structural basis for anaerobic alkane activation by a multisubunit glycyl radical enzyme.
1. Proc Natl Acad Sci U S A - published August 1, 2025
2. Andorfer MC, Levitz TS, Liu J, Chakraborty A, King-Roberts DT, Nweneka D, Imrich CN, Drennan CL
A cell isolation method from Ligusticum chuanxiong Hort. suitable for obtaining high-quality RNA for Smart-seq.
1. Plant Methods - published August 1, 2025
2. Li R, Wu M, Chen S, Huang L, Wang C, Yu Z, Huang F, Liu X, Zhu N, Song C, Jiang G, Yin X
Immunologic profiling of the infant immune response to whole-cell and acellular pertussis vaccines.
1. NPJ Vaccines - published August 1, 2025
2. Creech CB, Leguia M, Goll JB, Howard LM, Vila-Sanjurjo A, Yoder S, Juarez D, Garcia-Glaessner A, Gelber CE, Jimenez-Truque N, Cherikh S, Gil AI, Crowe JE, Cotos RC, Edwards KM, Lanata CF
Identification and Characterization of a Metal Binding-Independent Rift Valley Fever Virus Endonuclease Inhibitor.
1. ACS Infect Dis - published August 1, 2025
2. Kirby CD, Liu G, Fatma F, Pedlow MR, G-Dayanandan N, Sharma N, Frey ZD, Rush RE, Cardinale SC, Krezel AM, Hartman AL, Bowlin TL, Leung DW, Amarasinghe GK
FakeRotLib: Expedient Noncanonical Amino Acid Parametrization in Rosetta.
1. J Chem Inf Model - published August 1, 2025
2. Bell EW, Brown BP, Meiler J
Client-scaffold interactions suppress aggregation of a client protein in model condensates.
1. Proc Natl Acad Sci U S A - published August 1, 2025
2. Ahmed R, Hudson RP, Forman-Kay JD, Kay LE
Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes.
1. Nat Biotechnol - published August 1, 2025
2. Kreitz J, Yang V, Friedrich MJ, Pham J, Macrae RK, Zhang F
Lipid interactions and gating hysteresis suggest a physiological role for mechanosensitive channel YnaI.
1. Nat Commun - published August 1, 2025
2. Will N, Hiotis G, Nakayama Y, Angiulli G, Zhou Z, Cox CD, Martinac B, Walz T
Irreversible furin cleavage site exposure renders immature tick-borne flaviviruses fully infectious.
1. Nat Commun - published August 1, 2025
2. Holoubek J, Salát J, Matkovic M, Bednář P, Novotný P, Hradilek M, Majerová T, Rosendal E, Eyer L, Fořtová A, Beránková M, Bell-Sakyi L, Överby AK, Cavalli A, Bonomi M, Rey FA, Růžek D
Structure guided functional analysis of the S. cerevisiae Mre11 complex.
1. Nat Commun - published August 1, 2025
2. Hohl M, Yu Y, Kuryavyi V, Patel DJ, Petrini J
Deciphering the RNA recognition by Musashi-1 to design protein and RNA variants for in vitro and in vivo applications.
1. Nucleic Acids Res - published August 1, 2025
2. Pérez-Ràfols A, Pérez-Ropero G, Cerofolini L, Sperotto L, Roca-Martínez J, Higuera-Rodríguez RA, Russomanno P, Kaiser W, Vranken W, Danielson UH, Provenzani A, Martelli T, Sattler M, Buijs J, Fragai M
DNA TOPOISOMERASE II MUTATIONS IN CANCER: STRUCTURAL IMPACT AND DRUG RESPONSE IN HIGH-GRADE SEROUS OVARIAN CARCINOMA.
1. J Mol Biol - published August 1, 2025
2. Mazzoleni V, Boichard A, Lamour V
Mechanistic insights into the small-molecule inhibition of influenza A virus entry.
1. Proc Natl Acad Sci U S A - published August 1, 2025
2. Xu Y, Anirudhan V, Gaisina IN, Du H, Alqarni S, Moore TW, Caffrey M, Manicassamy B, Zhou T, Rong L, Xu K
Expanding the cytokine receptor alphabet reprograms T cells into diverse states.
1. Nature - published August 1, 2025
2. Zhao Y, Ogishi M, Pal A, Su LL, Tao P, Jiang H, Rodriguez GE, Chen X, Sun Q, Rysavy LW, Limsuwannarot S, Waghray D, Kalbasi A, Garcia KC
Clonal expansion and diversification of germinal center and memory B cell responses to booster immunization in primates.
1. Cell Rep - published August 1, 2025
2. Deimel LP, Nishimura Y, Silva Santos GS, Baharani VA, Hernandez B, Oliveira TY, MacLean AJ, Canis M, Shawraz S, Gazumyan A, Hartweger H, Bieniasz PD, Hatziioannou T, Martin MA, Nussenzweig MC
Spontaneous and experimental models of lymph node metastasis.
1. Nat Protoc - published August 1, 2025
2. Breuer CB, Xiong Z, Wang A, Rodriguez GE, Abhiraman GC, Garcia KC, Reticker-Flynn NE
Decoding Protein-Peptide Interactions Using a Large, Target-Agnostic Yeast Surface Display Library.
1. ACS Chem Biol - published August 1, 2025
2. Hurley JD, Shlosman I, Lakshminarayan M, Zhao Z, Yue H, Nowak RP, Fischer ES, Kruse AC
Structural Basis of PPARγ-Mediated Transcriptional Repression by the Covalent Inverse Agonist FX-909.
1. J Med Chem - published August 1, 2025
2. Laughlin ZT, Arifova L, Munoz-Tello P, Yu X, Giridhar MNK, Dong J, Harp JM, Zhu D, Kamenecka TM, Kojetin DJ
Infection with Mycobacterium tuberculosis alters the antibody response to HIV-1.
1. PLoS Pathog - published August 1, 2025
2. Zeeb M, Kusejko K, Hartnack S, Pasin C, Abela IA, Rusert P, Liechti T, Kadelka C, Notter J, Eichenberger A, Hoffmann M, Hirsch HH, Calmy A, Cavassini M, Labhardt ND, Bernasconi E, Günthard HF, Kouyos RD, Trkola A, Nemeth J, Swiss HIV Cohort Study
A virtual screening strategy to repurpose antifolate compounds as W. Bancrofti DHFR inhibitors.
1. Bioorg Med Chem Lett - published August 1, 2025
2. Kwarteng S, Wilhelm J, Salama M, Salama M, Hollander K, Anderson KS, Goodey NM, Frey KM
AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid.
1. mBio - published August 1, 2025
2. Chen DF, Roe LT, Yuping L, Borges AL, Zhang JY, Babbar P, Maji S, Stevens MGV, Correy GJ, Diolaiti ME, Smith DH, Ashworth A, Stroud RM, Kelly MJS, Bondy-Denomy J, Fraser JS
Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism.
1. Blood - published August 1, 2025
2. Sedzro JC, Photenhauer AL, Birkle F, Meze K, Mortenson A, Duckworth C, Wen PC, Kearns S, Cianfrocco MA, Tajkhorshid E, Ohi MD, Morrissey JH
PARP7 inhibition stabilizes STAT1/STAT2 and relieves experimental autoimmune encephalomyelitis in mice.
1. Cell Rep - published August 1, 2025
2. Xu J, Yu T, Yue Z, Lu X, Zhang Y, Wang L, Åhrling SS, Smith MR, Li YC, Matthews J, Lin H
CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection.
1. bioRxiv - published August 1, 2025
2. Schäfer JH, Calza A, Hom K, Damodar P, Peng R, Bogdanović N, Lander GC, Stagg SM, Cianfrocco MA
Lyotropy as a Design Consideration for Ultra-Small Protein Nanoparticles via Electrohydrodynamic Jetting.
1. Macromol Rapid Commun - published August 1, 2025
2. Iqbal MH, Zelaya J, Ong Q, Stellacci F, Lahann J
HMGB1 deforms nucleosomal DNA to generate a dynamic chromatin environment counteracting the effects of linker histone.
1. Sci Adv - published August 1, 2025
2. Saunders HS, Chio US, Moore CM, Ramani V, Cheng Y, Narlikar GJ
Blockade of interleukin-17A contributes to a novel mechanism by which casticin relieves chronic migraine.
1. J Ethnopharmacol - published August 1, 2025
2. Wen W, Chen H, Dai Y, Zhang S, Zhang H, Zhang H, Xiang J, Tang X, Liu X, Wang P, Xu S
High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs.
1. Nat Chem - published August 1, 2025
2. Carroll EC, Yang H, Powell WC, Charvat AF, Oehler A, Jones JG, Montgomery KM, Yung A, Millbern Z, Taylor AIP, Wilkinson M, Ranson NA, Radford SE, Vinueza NR, DeGrado WF, Mordes DA, Condello C, Gestwicki JE
VPS29C: Adding complexity to the Retromer complex.
1. Proc Natl Acad Sci U S A - published August 1, 2025
2. Chen B, Burstein E, Billadeau DD
Blockade of de novo dNTP biosynthesis pathway delays HIV-1 early life cycle kinetics and dynamics.
1. mBio - published August 1, 2025
2. Siddique MA, McRaven MD, Arif MS, Allen EJ, McKee C, Honne S, Sultana T, Kim B, Carias AM, Mamede JI, Hope TJ
Cryo-EM identifies F-ENA of Bacillus thuringiensis as a widespread family of endospore appendages across Firmicutes.
1. Nat Commun - published August 1, 2025
2. Sleutel M, Sogues A, Van Gerven N, Jonsmoen UL, Van Molle I, Fislage M, Theunissen LD, Bellis NF, Baquero DP, Egelman EH, Krupovic M, Wang F, Aspholm M, Remaut H
Clostridioides difficile toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity.
1. Mucosal Immunol - published August 1, 2025
2. Maslanka JR, Londregan JA, Denny JE, Hulit EN, Mdluli NV, Peritore-Galve FC, Alam MZ, Alameh MG, Lacy DB, Zackular JP, Abt MC
Exploration of a Class of Aryl Imidazolyl Ureas As Potent Acid Ceramidase Inhibitors for the Treatment of Fibrotic Diseases.
1. ACS Omega - published August 1, 2025
2. Beresis R, Prathigudupu V, Cable C, Yu A, Adler M, Ramamoorthi R, Yeon SK, Gordan JD, Sharma S, DeGrado WF, Zaro B, Chen JY, Jo H
Adeno-Associated Virus 2 (AAV2) - Induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression.
1. PLoS Pathog - published August 1, 2025
2. Summers MF, Haubold MK, Morgenstern M, Shepherd P, Larsen CIS, Bartz AE, Thirumoorthy G, Kirchdoerfer RN, Coon JJ, Mehta KPM, Majumder K
Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug.
1. Nat Struct Mol Biol - published August 1, 2025
2. Anton L, Cheng W, Haile MT, Dziekan JM, Cobb DW, Zhu X, Han L, Li E, Nair A, Lee CL, Wang H, Ke H, Zhang G, Doud EH, Cowman AF, Ho CM
17th GCC Closed Forum: Integrative Bioanalysis, Patient-centric Sampling, Emerging Technologies, Data Integrity, Sample Reconciliation, Discrepancies of ELISpot Data, Cross-validation Harmonization, Ultrasensitive Platforms for ADA Assays, Remote Regulatory Assessments, Shedding Assays by PCR, and Biomarker Tissue Assays.
1. Bioanalysis - published August 1, 2025
2. Zimmer J, O'dell M, Johnson D, Hays A, Gorityala S, Tary-Lehmann M, Malone K, Diaz M, Xu T, Dwivedi V, Dufield D, Iles T, Sikkema D, Majumdar R, Riccitelli N, Yuan M, Lowes S, Liu A, Matys K, Turksma A, Pirro J, Bergeron J, Karnik S, Voelker T, Salha D, Reynolds G, Lamy C, Yu M, Garofolo W, Nadarajah S, Leskovar A, Pellerin M, Veeramachaneni R, Kane C, Xu A, Hyer E, Carlsson A, Sanghvi M, Dompkowski E, Rundlett S, Bower J, Spytko A, Liu J, Gu W, Rocha A, O'Brien K, Fang X
Conversion of IscB and Cas9 into RNA-guided RNA editors.
1. Cell - published August 1, 2025
2. Xu C, Niu X, Sun H, Yan H, Tang W, Ke A
Structural elucidation of a unique binding mode by an intact alphavirus human IgG molecule to a quaternary epitope.
1. Nat Commun - published August 1, 2025
2. Bandyopadhyay A, Williamson LE, Sirohi D, Bailey K, Gilliland T Jr, Klose T, Buda G, Trivette A, Sun C, Julander JG, Klimstra WB, Crowe JE Jr, Kuhn RJ
Biochemistry and regulation of histone lysine L-lactylation.
1. Nat Rev Mol Cell Biol - published August 1, 2025
2. Sheng X, Lin H, Cole PA, Zhao Y
The C-terminal domain of SARS-CoV-2 nsp8 is a molten globule in the absence of binding partners.
1. J Mol Biol - published August 1, 2025
2. Kurauskas V, Tonelli M, Kirchdoerfer RN, Henzler-Wildman K
Recombinant live attenuated measles virus-based vaccines inducing comprehensive protection against Ebola and Marburg viruses.
1. Mol Ther - published August 1, 2025
2. Zhou J, Zhang X, Yao Y, Xie Y, Li F, Wang W, Yan F, Peng C, Zhang B, Wu Y, Cao Z, Peng Y, Gao G, Zhang H, Gong P, Chiu S
Peroxidase modification-driven silymarin liposomes for the treatment of liver fibrosis.
1. Nanomedicine - published August 1, 2025
2. Wu J, Liu X, Wen L, Liang C, Sun Z, Liu X, Wang S, Li X
MarK, a Novosphingobium aromaticivorans kinase required for catabolism of multiple aromatic monomers.
1. J Biol Chem - published August 1, 2025
2. Hall BW, Neri JC, Bingman CA, Vilbert AC, Eckmann JB, Myers KS, Sibert BS, Wright ER, Fox BG, Kiley PJ, Noguera DR, Donohue TJ
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia.
1. Cell - published August 1, 2025
2. Lange SM, Bennett JA, Eisert RJ, Brown A
3D Multi-Tissue microphysiological system for Anti-Cancer and cardiotoxicity drug screening with automated image analysis.
1. Discov Appl Sci - published August 1, 2025
2. Borrego EA, Perez JL, Esparza A, Delgado P, Moreno K, Poon W, Chambers D, Joddar B, Natividad-Diaz SL
Mechanistic insights and in vivo HIV suppression by the BRD4-targeting small molecule ZL0580.
1. bioRxiv - published August 1, 2025
2. Kumar N, Ma Z, Long F, Bonam SR, Lai HT, Wu SY, Chen H, Hazell NC, Bei J, Liu X, Wei Z, Chiang CM, Zhou J, Hu H
Temporal Clonal Tracing and Functional Perturbation Reveal Niche-Adaptive and Tumor-Intrinsic IFNγ Dependencies Driving Ovarian Cancer Metastasis.
1. bioRxiv - published August 1, 2025
2. Aleksandrovic E, Fross SR, Golomb SM, Liu X, Zhao Z, Das NM, Reese TC, Ma W, Lopez J, Stack MS, Zhao M, Zhang S
Harnessing Digital Health Technologies to Combat Climate Change-Related Health Impacts.
1. Health Care Sci - published August 1, 2025
2. Li Y, Wu G, Gong P, Liu C, Liang L, Gong M, Zeng Z
Coverage and Prior Authorization Policies for Semaglutide and Tirzepatide in Medicare Part D Plans.
1. JAMA Netw Open - published August 1, 2025
2. Liu X, Lu CA, Shih YT, Jiang C
Unc-51 Like Kinase 3 (ULK3) is essential for autophagy and cell survival in multiple myeloma.
1. Res Sq - published August 1, 2025
2. Tauro M, Li T, Sudalagunta PR, Meads M, Canevarolo RR, Nerlakanti N, Alugubelli RR, Lawrence HR, Gunawan S, Ayaz M, Nareddy P, Yun SY, Shay G, Yang K, Tran TH, Bishop RT, Nasr MM, Lawrence NNJ, Schönbrunn E, Cleveland JL, Silva AS, Shain KH, Lynch CC