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83 Member Publications for January

Previous Month

Investigating Complexin-Membrane Interactions Using NMR and Optical Methods.
1. Methods Mol Biol - published January 13, 2025
2. Grasso EM, Eliezer D
TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids.
1. Cancer Immunol Res - published January 9, 2025
2. Sun Y, Maggs L, Panda A, Wright SJ, Cicerchia AM, Jenney A, Perricone MD, Mills CE, Cattaneo G, Ventin M, Chen F, Rasmussen MQ, Miranda A, Revach OY, Fang J, Fu A, Bowling PJ, Sharova T, Lawless A, Sorger PK, Bardeesy N, Wang X, Flaherty KT, Boland GM, Mehta A, Sade-Feldman M, Ferrone CR, Jenkins RW
Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan.
1. Skelet Muscle - published January 9, 2025
2. Hord JM, Burns S, Willer T, Goddeeris MM, Venzke D, Campbell KP
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands.
1. Mol Neurodegener - published January 9, 2025
2. Greven JA, Wydra JR, Greer RA, Zhi C, Price DA, Svoboda JD, Camitta CLM, Washington M, Leung DW, Song Y, Alexander-Brett J, Brett TJ
Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation.
1. Nat Commun - published January 9, 2025
2. Czyzyk D, Yan W, Messing S, Gillette W, Tsuji T, Yamaguchi M, Furuzono S, Turner DM, Esposito D, Nissley DV, McCormick F, Simanshu DK
DARPin-induced reactivation of p53 in HPV-positive cells.
1. Nat Struct Mol Biol - published January 9, 2025
2. Münick P, Strubel A, Balourdas DI, Funk JS, Mernberger M, Osterburg C, Dreier B, Schaefer JV, Tuppi M, Yüksel B, Schäfer B, Knapp S, Plückthun A, Stiewe T, Joerger AC, Dötsch V
An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.
1. Sci Transl Med - published January 8, 2025
2. Swanson OM, Zhang QE, Van Itallie E, Tian M, Brown AR, Harris C, Kapingidza AB, Rhodes B, Smith LM, Venkatayogi S, Cronin K, Frazier M, Parks R, Bar M, Jiang C, Martin Beem JS, Cheng HL, Davis J, McGovern K, Newman A, Edwards RJ, Cain D, Alam SM, Wiehe K, Saunders KO, Acharya P, Alt F, Haynes BF, Azoitei ML
Metagenomics reveals spatial variation in cyanobacterial composition, function, and biosynthetic potential in the Winam Gulf, Lake Victoria, Kenya.
1. Appl Environ Microbiol - published January 8, 2025
2. Hart LN, Zepernick BN, Natwora KE, Brown KM, Obuya JA, Lomeo D, Barnard MA, Okech EO, 2022-23 NSF-IRES Lake Victoria Research Consortium, Kiledal EA, Den Uyl PA, Olokotum M, Wilhelm SW, McKay RM, Drouillard KG, Sherman DH, Sitoki L, Achiya J, Getabu A, Otiso KM, Bullerjahn GS, Dick GJ
Structural basis for the transport and regulation mechanism of the multidrug resistance-associated protein 2.
1. Nat Commun - published January 8, 2025
2. Koide E, Pietz HL, Beltran J, Chen J
RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation.
1. Nat Struct Mol Biol - published January 8, 2025
2. Brewer JJ, Inlow K, Mooney RA, Bosch B, Olinares PDB, Marcelino LP, Chait BT, Landick R, Gelles J, Campbell EA, Darst SA
Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.
1. Elife - published January 8, 2025
2. Giese APJ, Weng WH, Kindt KS, Chang HHV, Montgomery JS, Ratzan EM, Beirl AJ, Aponte Rivera R, Lotthammer JM, Walujkar S, Foster MP, Zobeiri OA, Holt JR, Riazuddin S, Cullen KE, Sotomayor M, Ahmed ZM
DJK-5, an anti-biofilm peptide, increases Staphylococcus aureus sensitivity to colistin killing in co-biofilms with Pseudomonas aeruginosa.
1. NPJ Biofilms Microbiomes - published January 8, 2025
2. Wardell SJT, Yung DBY, Gupta A, Bostina M, Overhage J, Hancock REW, Pletzer D
Formation of I(2)+III(2) supercomplex rescues respiratory chain defects.
1. Cell Metab - published January 8, 2025
2. Liang C, Padavannil A, Zhang S, Beh S, Robinson DRL, Meisterknecht J, Cabrera-Orefice A, Koves TR, Watanabe C, Watanabe M, Illescas M, Lim R, Johnson JM, Ren S, Wu YJ, Kappei D, Ghelli AM, Funai K, Osaka H, Muoio D, Ugalde C, Wittig I, Stroud DA, Letts JA, Ho L
Substrate adaptors are flexible tethering modules that enhance substrate methylation by the arginine methyltransferase PRMT5.
1. J Biol Chem - published January 8, 2025
2. Jin CY, Hunkeler M, Mulvaney KM, Sellers WR, Fischer ES
Higher-order transient structures and the principle of dynamic connectivity in membrane signaling.
1. Proc Natl Acad Sci U S A - published January 7, 2025
2. Zhang Y, MacKinnon R
Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications.
1. Nat Struct Mol Biol - published January 7, 2025
2. Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice.
1. Nat Commun - published January 7, 2025
2. Halfmann PJ, Patel RS, Loeffler K, Yasuhara A, Van De Velde LA, Yang JE, Chervin J, Troxell C, Huang M, Zheng N, Wright ER, Thomas PG, Wilson PC, Kawaoka Y, Kane RS
Single-molecule analysis reveals that IPMK enhances the DNA-binding activity of the transcription factor SRF.
1. Nucleic Acids Res - published January 7, 2025
2. Ahn H, Yu J, Ryu K, Ryu J, Kim S, Park JY, Kim JK, Jung I, An H, Hong S, Kim E, Park K, Ahn M, Min S, Jung I, Lee D, Lee T, Byun Y, Song JJ, Kim J, Cho WK, Lee G, Kim S
DNA targeting by compact Cas9d and its resurrected ancestor.
1. Nat Commun - published January 7, 2025
2. Ocampo RF, Bravo JPK, Dangerfield TL, Nocedal I, Jirde SA, Alexander LM, Thomas NC, Das A, Nielson S, Johnson KA, Brown CT, Butterfield CN, Goltsman DSA, Taylor DW
Mechanism-guided engineering of a minimal biological particle for genome editing.
1. Proc Natl Acad Sci U S A - published January 7, 2025
2. Ngo W, Peukes J, Baldwin A, Xue ZW, Hwang S, Stickels RR, Lin Z, Satpathy AT, Wells JA, Schekman R, Nogales E, Doudna JA
Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus.
1. J Cell Biol - published January 6, 2025
2. Fung HYJ, Jiou J, Niesman AB, Bernardes NE, Chook YM
Artificial Metalloenzymes with Two Catalytic Cofactors for Tandem Abiotic Transformations.
1. Angew Chem Int Ed Engl - published January 6, 2025
2. Wang W, Tachibana R, Zhang K, Lau K, Pojer F, Ward TR, Hu X
Replacement of a single residue changes the primary specificity of thrombin.
1. Fertil Steril - published January 6, 2025
2. Rossi AD, Deavila S, Mohammed BM, Korolev S, Di Cera E
Alcohol and substance use differentially impact suicidal ideation in a longitudinal cohort of bipolar disorder.
1. Psychiatry Res - published January 6, 2025
2. Smith JL, McInnis MG, Sperry SH
Long-Term Protein Synthesis with PURE in a Mesoscale Dialysis System.
1. ACS Synth Biol - published January 5, 2025
2. Roset Julià L, Grasemann L, Stellacci F, Maerkl SJ
RosettaHDX: Predicting antibody-antigen interaction from hydrogen-deuterium exchange mass spectrometry data.
1. J Struct Biol - published January 5, 2025
2. Tran MH, Martina CE, Moretti R, Nagel M, Schey KL, Meiler J
Elevated Levels of Serum Alpha-2-Macroglobulin Associate with Diabetes Status and Incident Cardiovascular Disease in Type 1 Diabetes.
1. J Lipid Res - published January 4, 2025
2. Shao B, Snell-Bergeon JK, de Boer IH, Davidson WS, Bornfeldt KE, Heinecke JW
Cross-modal sensory compensation increases mosquito attraction to humans.
1. Sci Adv - published January 3, 2025
2. Morita T, Lyn NG, von Heynitz RK, Goldman OV, Sorrells TR, DeGennaro M, Matthews BJ, Houri-Zeevi L, Vosshall LB
The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes.
1. EMBO J - published January 3, 2025
2. Melnikov N, Junglas B, Halbi G, Nachmias D, Zerbib E, Gueta N, Upcher A, Zalk R, Sachse C, Bernheim-Groswasser A, Elia N
The impact of library size and scale of testing on virtual screening.
1. Nat Chem Biol - published January 3, 2025
2. Liu F, Mailhot O, Glenn IS, Vigneron SF, Bassim V, Xu X, Fonseca-Valencia K, Smith MS, Radchenko DS, Fraser JS, Moroz YS, Irwin JJ, Shoichet BK
Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity.
1. Nat Cell Biol - published January 3, 2025
2. Latorre-Muro P, Vitale T, Ravichandran M, Zhang K, Palozzi JM, Bennett CF, Lamas-Paz A, Sohn JH, Jackson TD, Jedrychowski M, Gygi SP, Kajimura S, Schmoker A, Jeon H, Eck MJ, Puigserver P
A risk-based approach can guide safe cell line development and cell banking for scaled-up cultivated meat production.
1. Nat Food - published January 3, 2025
2. Bennie RZ, Ogilvie OJ, Loo LSW, Zhou H, Ng SK, Jin A, Trlin HJF, Wan A, Yu H, Domigan LJ, Dobson RCJ
A bipartite bacterial virulence factor targets the complement system and neutrophil activation.
1. EMBO J - published January 3, 2025
2. Kurniyati K, Clark ND, Wang H, Deng Y, Sze CW, Visser MB, Malkowski MG, Li C
Replacement of a single residue changes the primary specificity of thrombin.
1. J Thromb Haemost - published January 3, 2025
2. Rossi AD, Deavila S, Mohammed BM, Korolev S, Di Cera E
Towards Improved Peptidic α-Ketoamide Inhibitors of the Plasmodial Subtilisin-Like SUB1: Exploration of N-Terminal Extensions and Cyclic Constraints.
1. ChemMedChem - published January 2, 2025
2. Puszko AK, Batista FA, Ejjoummany A, Bouillon A, Maurel M, Adler P, Legru A, Martinez M, Ortega Varga L, Hadjadj M, Alzari PM, Blondel A, Haouz A, Barale JC, Hernandez JF
MCTS2 and distinct eIF2D roles in uORF-dependent translation regulation revealed by in vitro re-initiation assays.
1. EMBO J - published January 2, 2025
2. Meurs R, De Matos M, Bothe A, Guex N, Weber T, Teleman AA, Ban N, Gatfield D
HBV DNA integration and somatic mutations in HCC patients with HBV-HCV dual infection reveals profiles intermediate between HBV- and HCV-related HCC.
1. J Biomed Sci - published January 2, 2025
2. Li CL, Hsu CL, Lin YY, Ho MC, Hu RH, Tzeng ST, Wang YC, Tanaka Y, Chen PJ, Yeh SH
Discovery of High-Affinity SMARCA2/4 Bromodomain Ligands and Development of Potent and Exceptionally Selective SMARCA2 PROTAC Degraders.
1. J Med Chem - published January 2, 2025
2. Leng L, Tu W, Yang L, Huang L, Wang M, Meagher JL, Chinnaswamy K, Allu SR, Rej RK, Tošović J, Harikrishnan L, Li Z, Sui Z, Stuckey JA, Wang S
Discovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers.
1. J Med Chem - published January 2, 2025
2. Yang L, Tu W, Leng L, Huang L, Jiang W, Wang M, Wang Y, Meagher JL, Chinnaswamy K, Stuckey JA, Wang M, Wen B, Sun D, Harikrishnan L, Strickland C, Rice C, Orth P, Sui Z, Wang S
The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling.
1. Elife - published January 2, 2025
2. Bruguera ES, Mahoney JP, Weis WI
Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase.
1. Nat Commun - published January 2, 2025
2. Roberts JR, Horibata Y, Kwarcinski FE, Lam V, Raczkowski AM, Hubbard A, White B, Sugimoto H, Tall GG, Ohi MD, Maeda S
Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy.
1. Sci Rep - published January 2, 2025
2. Schnicker NJ, Xu Z, Amir M, Gakhar L, Huang CL
Rational engineering of minimally immunogenic nucleases for gene therapy.
1. Nat Commun - published January 2, 2025
2. Raghavan R, Friedrich MJ, King I, Chau-Duy-Tam Vo S, Strebinger D, Lash B, Kilian M, Platten M, Macrae RK, Song Y, Nivon L, Zhang F
The Future Hospital in Global Health Systems: The Future Hospital as an Entity.
1. Int J Health Plann Manage - published January 2, 2025
2. Nj S, A A, L A, L C, A C, M G, M G, F M, Y N, Onoka C, McKee M
A divergent two-domain structure of the anti-Müllerian hormone prodomain.
1. Proc Natl Acad Sci U S A - published January 2, 2025
2. Howard JA, Hok L, Cate RL, Sanford NJ, Hart KN, Leach EAE, Bruening AS, Nagykery N, Donahoe PK, Pépin D, Thompson TB
IgA class switching enhances neutralizing potency against SARS-CoV-2 by increased antibody hinge flexibility.
1. Antiviral Res - published January 1, 2025
2. Xu M, Zhang Z, Sun Y, Mai H, Liu S, Liu S, Lv K, Yu F, Wang Y, Yue X, Zhang J, Cai X, Zhao R, Lu H, Liu L, Luo H, Zhao H, Wang Y, Gong P, Chen S, Jing X, Zhao J, Chen YQ
Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering.
1. Nat Commun - published January 1, 2025
2. Grubbe WS, Zhang B, Kauffman A, Byléhn F, Padoł K, Jung HG, Park SB, Priest JM, Özkan E, de Pablo JJ, Liang TJ, Zhao M, Mendoza JL
Structural development of the HIV-1 apex-directed PGT145-PGDM1400 antibody lineage.
1. Cell Rep - published January 1, 2025
2. Mason RD, Zhang B, Morano NC, Shen CH, McKee K, Heimann A, Du R, Nazzari AF, Hodges S, Kanai T, Lin BC, Louder MK, Doria-Rose NA, Zhou T, Shapiro L, Roederer M, Kwong PD, Gorman J
Structural basis for the interaction between the Drosophila RTK Sevenless (dROS1) and the GPCR BOSS.
1. Nat Commun - published January 1, 2025
2. Zhang J, Tsutsui Y, Li H, Li T, Wang Y, Laraki S, Alarcon-Frias S, Stayrook SE, Klein DE
Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity.
1. Nat Cancer - published January 1, 2025
2. Liang J, Vitale T, Zhang X, Jackson TD, Yu D, Jedrychowski M, Gygi SP, Widlund HR, Wucherpfennig KW, Puigserver P
Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns.
1. ACS Chem Biol - published January 1, 2025
2. Fedorova O, Luo M, Jagdmann GE Jr, Van Zandt MC, Sisto L, Pyle AM
Structural basis for metal ion transport by the human SLC11 proteins DMT1 and NRAMP1.
1. Nat Commun - published January 1, 2025
2. Liziczai M, Fuchs A, Manatschal C, Dutzler R
Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential.
1. Adv Sci (Weinh) - published January 1, 2025
2. Wei K, Arlotto M, Overhulse JM, Dinh TA, Zhou Y, Dupper NJ, Yang J, Kashemirov BA, Dawi H, Garnaud C, Bourgine G, Mietton F, Champleboux M, Larabi A, Hayat Y, Indorato RL, Noirclerc-Savoye M, Skoufias D, Cornet M, Rabut G, McKenna CE, Petosa C, Govin J
Structural dynamics and binding of Caenorhabditis elegans lifespan-extending lipid binding protein-3 to polyunsaturated fatty acids.
1. Protein Sci - published January 1, 2025
2. Cuevas AR, Tillman MC, Wang MC, Ortlund EA
Structure of Plasmodium vivaxN-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy.
1. Acta Crystallogr F Struct Biol Commun - published January 1, 2025
2. Mendez A, Bolling C, Taylor S, Makumire S, Staker B, Reers A, Hammerson B, Mayclin SJ, Abendroth J, Lorimer DD, Edwards TE, Tate EW, Subramanian S, Bell AS, Myler PJ, Asojo OA, Chakafana G
Loss of Cdkn1a protects against MASLD alone or with alcohol intake by preserving lipid homeostasis.
1. JHEP Rep - published January 1, 2025
2. Lamas-Paz A, Hionides-Gutiérrez A, Guo F, Jorquera G, Morán-Blanco L, Benedé-Ubieto R, Mesquita M, Estévez-Vázquez O, Zheng K, Mazariegos M, Vázquez-Ogando E, Blázquez-López E, Asensio I, Mutlu B, Gomez-Santos B, Peligros MI, Vaquero J, Bañares R, Delgado TC, Martínez-Chantar ML, Martínez-Naves E, Sanz-García C, Mohamed MR, Tesolato S, Iniesta P, Gallego-Durán R, Maya-Miles D, Ampuero J, Romero-Gómez M, Martínez-Alcocer A, Sanfeliu-Redondo D, Fernández-Iglesias A, Gracia-Sancho J, Coll M, Graupera I, Ginès P, Ciudin A, Rivera-Esteban J, Pericàs JM, Ávila MA, Frutos MD, Martínez-Cáceres CM, Ramos-Molina B, Aspichueta P, Puigserver P, Nevzorova YA, Cubero FJ
Structural diversity of axonemes across mammalian motile cilia.
1. Nature - published January 1, 2025
2. Leung MR, Sun C, Zeng J, Anderson JR, Niu Q, Huang W, Noteborn WEM, Brown A, Zeev-Ben-Mordehai T, Zhang R
Vaccination with different group 2 influenza subtypes alters epitope targeting and breadth of hemagglutinin stem-specific human B cells.
1. Sci Transl Med - published January 1, 2025
2. Mantus GE, Chopde AJ, Gorman J, Cominsky LY, Ourahmane A, Creanga A, Shimberg GD, Gillespie RA, Van Wazer DJ, Zhou T, Gajjala SR, Williams C, Maestle E, Reed DS, Serebryannyy L, Costner P, Holman L, Casazza JP, Koup RA, Dropulic LK, Kwong PD, McDermott AB, Kanekiyo M, Andrews SF
Alterations in Cellular Gene Expression Due to Co-Infection With Kaposi's Sarcoma-Associated Herpesvirus and SARS-CoV-2: Implications for Disease Severity.
1. J Med Virol - published January 1, 2025
2. Chen J, Fan J, Malaviarachchi PA, Post SR, Lin Z, Zhang X, Qin Z
Structural basis for TIR domain-mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM.
1. Proc Natl Acad Sci U S A - published January 1, 2025
2. Manik MK, Pan M, Xiao L, Gu W, Kim H, Pospich S, Hedger A, Vajjhala PR, Lee MYL, Qian X, Landsberg MJ, Ve T, Nanson JD, Raunser S, Stacey KJ, Wu H, Kobe B
Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication.
1. Nat Commun - published January 1, 2025
2. Lee D, Koo B, Kim S, Byun J, Hong J, Shin DY, Sun CH, Kim J, Song JJ, Jaiswal S, Yoon SS, Kim S, Koh Y
Accessing ultrastable glass via a bulk transformation.
1. Nat Commun - published January 1, 2025
2. Bu H, Luan H, Kang J, Jia J, Guo W, Su Y, Ding H, Chang HS, Wang R, Wu Y, Shi L, Gong P, Zeng Q, Shao Y, Yao K
The UBR domain of plant Ubr1 homolog PRT6 accommodates basic and hydrophobic amino termini for substrate recognition.
1. J Mol Biol - published January 1, 2025
2. Rudi O, Hodakova Z, Saad CF, Winter N, Grishkovskaya I, Böhm J, Jarck G, Schleiffer A, Haselbach D, Bachmair A
Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13.
1. Nat Commun - published January 1, 2025
2. Cheng SJ, Gafaar T, Kuttiyatveetil JRA, Sverzhinsky A, Chen C, Xu M, Lilley A, Pascal JM, Leung AKL
Interpretable Deep-Learning pK(a) Prediction for Small Molecule Drugs via Atomic Sensitivity Analysis.
1. J Chem Inf Model - published January 1, 2025
2. DeCorte J, Brown B, Jeffrey R, Meiler J
Dual-Cys bacteriophytochromes: intermediates in cyanobacterial phytochrome evolution?
1. FEBS J - published January 1, 2025
2. Yang HW, Song JY, Song JJ, Kim YW, Rockwell NC, Kim W, Kim H, Lagarias JC, Park YI
NADH-bound AIF activates the mitochondrial CHCHD4/MIA40 chaperone by a substrate-mimicry mechanism.
1. EMBO J - published January 1, 2025
2. Brosey CA, Shen R, Tainer JA
Structural determinants of peanut induced anaphylaxis.
1. J Allergy Clin Immunol - published January 1, 2025
2. Smith SA, Shrem RA, Lança BBC, Zhang J, Wong JJW, Croote D, Peebles RS Jr, Spiller BW
Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis.
1. Nat Commun - published January 1, 2025
2. Cicuéndez B, Mora A, López JA, Curtabbi A, Pérez-García J, Porteiro B, Jimenez-Blasco D, Latorre-Muro P, Vo P, Jerome M, Gómez-Santos B, Romero-Becerra R, Leiva M, Rodríguez E, León M, Leiva-Vega L, Gómez-Lado N, Torres JL, Hernández-Cosido L, Aguiar P, Marcos M, Jastroch M, Daiber A, Aspichueta P, Bolaños JP, Spinelli JB, Puigserver P, Enriquez JA, Vázquez J, Folgueira C, Sabio G
Structure of transmembrane AMPA receptor regulatory protein subunit γ2.
1. Nat Commun - published January 1, 2025
2. Hale WD, Romero AM, Koylass N, Warrick CR, Qiu Z, Huganir RL, Twomey EC
Context-Dependent Heterotypic Assemblies of Intrinsically Disordered Peptides.
1. J Am Chem Soc - published January 1, 2025
2. Qiao Y, Zia A, Wu G, Liu Z, Guo J, Chu M, He H, Wang F, Xu B
Discovery of non-retinoid compounds that suppress the pathogenic effects of misfolded rhodopsin in a mouse model of retinitis pigmentosa.
1. PLoS Biol - published January 1, 2025
2. Ortega JT, Gallagher JM, McKee AG, Tang Y, Carmena-Bargueňo M, Azam M, Pashandi Z, Golczak M, Meiler J, Pérez-Sánchez H, Schlebach JP, Jastrzebska B
Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA.
1. Commun Biol - published January 1, 2025
2. Megrian D, Martinez M, Alzari PM, Wehenkel AM
Conditional requirement for dimerization of the membrane-binding module for BTK signaling in lymphocyte cell lines.
1. Sci Signal - published January 1, 2025
2. Eisen TJ, Ghaffari-Kashani S, Hung CL, Groves JT, Weiss A, Kuriyan J
Antigenic determinants underlying IgE-mediated anaphylaxis to peanut.
1. J Allergy Clin Immunol - published January 1, 2025
2. Smith SA, Khan YW, Shrem RA, Hemler JA, Doyle JE, Daniel J, Zhang J, Pena-Amelunxen G, Aglas L, Hamilton RG, Getts R, Sampson HA, Wong JJW, Croote D, Peebles RS Jr, Spiller BW
Directed evolution of an orthogonal transcription engine for programmable gene expression in eukaryotes.
1. iScience - published January 1, 2025
2. Kar S, Gardner EC, Javanmardi K, Boutz DR, Shroff R, Horton AP, Segall-Shapiro TH, Ellington AD, Gollihar J
OPTO: Automated Optimization for Solid-State NMR Spectroscopy.
1. J Am Chem Soc - published January 1, 2025
2. Borcik CG, DeZonia B, Ravula T, Harding BD, Garg R, Rienstra CM
Mitoregulin self-associates to form likely homo-oligomeric pore-like complexes.
1. iScience - published January 1, 2025
2. Linzer CR, Stein CS, Witmer NH, Xu Z, Schnicker NJ, Boudreau RL
Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross-stage recognition of glutamate-rich repeats.
1. Elife - published January 1, 2025
2. Amen A, Yoo R, Fabra-García A, Bolscher J, Stone WJR, Bally I, Dergan-Dylon S, Kucharska I, de Jong RM, de Bruijni M, Bousema T, King CR, MacGill RS, Sauerwein RW, Julien JP, Poignard P, Jore MM
Coordinated neuron-specific splicing events restrict nucleosome engagement of the LSD1 histone demethylase complex.
1. Cell Rep - published January 1, 2025
2. Porter RS, An S, Gavilan MC, Nagai M, Murata-Nakamura Y, Zhou B, Bonefas KM, Dionne O, Manuel JM, St-Germain J, Gascon S, Kim J, Browning L, Laurent B, Cho US, Iwase S
Mechanistic determinants and dynamics of cA6 synthesis in type III CRISPR-Cas effector complexes.
1. Nucleic Acids Res - published January 1, 2025
2. Jungfer K, Moravčík Š, Garcia-Doval C, Knörlein A, Hall J, Jinek M
Mapping C. difficile TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling.
1. mBio - published January 1, 2025
2. Ward JS, Schreiber KJ, Tam J, Youn J-Y, Melnyk RA
The reversible capillary field effect transistor: a capillaric element for autonomous flow switching.
1. Lab Chip - published January 1, 2025
2. Mak D, Meffan C, Menges J, Marchant-Ludlow R, Hashemi A, Moore CP, Dobson RCJ, Nock V