Supported Applications
ThermoMPNN-D
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Description
is a Siamese neural network designed to predict stability changes from protein double point mutations. The tool extends ThermoMPNN and ProteinMPNN, offering three prediction modes: single mutant, additive double mutant (which sums individual contributions), and epistatic double mutant (which captures epistatic interactions between mutations). It provides fast inference through batched predictions and includes tools for systematic analysis of all possible single or double mutants in a protein structure, outputting mutation and ΔΔG values.
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Usage
To list all executables provided by ThermoMPNN-D, run:$ sbgrid-list thermompnn-d -
Installation
Use the following command to install this title with the CLI client:$ sbgrid-cli install thermompnn-dAvailable operating systems: Linux 64
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Keywords
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Default Versions
Linux 64: 20260107 (10.8 GB)