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CryoBoltz

  • Description

    CryoBoltz is a method for fitting atomic structures into cryo-EM density maps of dynamic proteins. It is built on top of Boltz-1, a state-of-the-art structure prediction model for biomolecular complexes. Through a multi-stage guidance mechanism that modifies the Boltz diffusion trajectory at inference time, CryoBoltz recovers diverse conformations from input cryo-EM data.

  • Usage

    To list all executables provided by CryoBoltz, run: $ sbgrid-list cryoboltz Copy to clipboard

  • Usage Notes

    The "boltz" command exists both in Boltz tilte and Cryoboltz. To check the title in use: boltz --sbwhich If it is not the desired one, use this command to change it: boltz --sbapp:a cryoboltz To make that permanent, you need to create ~/.sbgrid_capsule folder first: mkdir ~/.sbgrid_capsule/ and then create a file in that folder by doing: echo cryoboltz > ~/.sbgrid_capsule/boltz check: boltz --sbwhich See more details in: https://docs.sbgrid.org/environment/capsules/?h=duplicate#sbgrid-useful-commands

  • Installation

    Use the following command to install this title with the CLI client: $ sbgrid-cli install cryoboltz Copy to clipboard Available operating systems: Linux 64

  • Primary Citation*

    R. Raghu, A. Levy, G. Wetzstein, and E. D. Zhong. 2025. Multiscale guidance of protein structure prediction with heterogeneous cryo-EM data. arXiv.


    • *Full citation information available through

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