Our March webinar will feature Thomas Grant, postdoctoral scholar at the Hauptman-Woodward Medical Research Institute. Thomas will give us a two part primer on Biological Small Angle Scattering (SAXS). This webinar will be recorded and made available to members through the SBGridTV YouTube channel. Please be sure to subscribe to this channel to receive notifications when new webinars are added.

This review (Putnam et al, Q REv Biophys. 2007 Aug; 40(3):191-285) is recommended for anyone interested in additional information on using SAXS in combination with crystallography and computational methods.

Small angle scattering is a solution technique enabling the acquisition of low resolution structural information from a dilute, monodisperse solution of macromolecules. SAS can yield information about the size and shape of particles in solution, degree of foldedness of a particle, and can reveal oligomeric state and organization. Part I of this course will offer an introduction to the theory of small angle X-ray and neutron scattering, applications to biological systems, data collection strategies, characterization of sample quality and basic modeling techniques. Part II will discuss more advanced applications of small angle scattering including contrast matching, ensemble modeling, complementary methods, hybrid structural modeling, and analysis of mixtures. .

Host: Jason Key