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20 Member Publications for March 2026

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The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation.
1. Sci Rep - published March 7, 2026
2. Li H, Guan H, Rapoport TA
Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants.
1. Cancer Discov - published March 6, 2026
2. Stahlhut C, Maciag AE, Sullivan KA, Singh K, Gitego N, Zhang Z, Chan AH, Sharma AK, Alexander PA, Shu J, Yang Y, Rigby M, Ma R, Setoodeh S, Smith BP, Pei J, Rabara D, Larsen EK, Turner DM, Zhang C, Feng C, Feng S, Stice JP, Xu R, Lin K, Stephen AG, Lightstone FC, Ji C, Wang K, Simanshu DK, Nissley DV, Wallace E, Wang B, Sinkevicius KW, McCormick F, Beltran PJ
Direct Measurement of Protein Pair Interaction Potential.
1. ACS Nano - published March 6, 2026
2. Poliukhina E, Ong Q, Demurtas D, Uchikawa E, Shafie N, Stellacci F
Editorial: Modeling the immune system: from PK/PD to systems immunology.
1. Front Immunol - published March 5, 2026
2. Alfonso-González L, Fernández FJ, Vega MC
Structural modeling reveals phage proteins that manipulate bacterial immune signaling.
1. Science - published March 5, 2026
2. Tal N, Hadary R, Chang RB, Osterman I, Jacobson R, Yirmiya E, Bechon N, Hochhauser D, López Rivera M, Madhala B, Garb J, Goldsmith M, Wein T, Kranzusch PJ, Amitai G, Sorek R
A Dual-Model Machine Learning Framework for Interpretable Design and Ensemble Prediction of C-Amidated Antimicrobial Peptides.
1. ACS Appl Mater Interfaces - published March 5, 2026
2. Le DH, Zhu Y, Zhang T, Li W, Hung A, Houshyar S, Le TC
Evolutionary remodeling of a remnant GET pathway factor into PEX38, an essential peroxin.
1. Proc Natl Acad Sci U S A - published March 3, 2026
2. Krishna CK, Gaussmann S, Das H, Jung M, Oeljeklaus S, Sattler M, Warscheid B, Kalel VC, Erdmann R
Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control.
1. Nat Immunol - published March 3, 2026
2. Fisher K, Garcia MA, Frattari GS, Naasz C, Zhuo J, Rosás-Umbert M, Dietz LL, Juhl AK, Falling Iversen E, Olesen R, Schleimann MH, Pahus MH, Johansen IS, Henderson M, Carrere L, Roseto I, Gao C, Yu XG, Fray EJ, Aydin B, Lubbeck D, Lai J, Simonetti FR, Danesh A, Miller I, Mendoza P, Niessl J, Gaebler C, Seaman MS, Kaufmann DE, Lehmann C, Gruell H, Klein F, Caskey M, Nussenzweig MC, Tolstrup M, Jones RB, Gunst JD, Siliciano JD, Lichterfeld M, Siliciano RF, Søgaard OS
Hour-scale single-molecule imaging reveals dynamic assembly of the Wnt co-receptors LRP6 and ROR2 into common signalosomes.
1. Sci Signal - published March 3, 2026
2. Philippi M, Dohle J, Watrinet I, Holtmannspötter M, Miao Y, Li J, Birkholz O, Rothbauer U, Garcia KC, Kurre R, Piehler J, You C
Surface Morphometrics reveals local membrane thickness variation in organellar subcompartments.
1. J Cell Biol - published March 2, 2026
2. Medina M, Chang YT, Rahmani H, Frank M, Khan Z, Fuentes D, Heberle FA, Waxham MN, Barad BA, Grotjahn DA
Transcription of HIV-1 is heterogenous among authentic latent CD4+ T cell clones.
1. J Exp Med - published March 2, 2026
2. Bittar C, Teixeira AR, Oliveira TY, Silva Santos GS, Lenart K, Fumagalli MJ, Weymar GHJ, Kaczynska A, Linden NL, Ferreira IATM, Caskey M, Jones RB, Jankovic M, Nussenzweig MC
Epitope-spanning antigenic variation reprograms immunodominance and broadens immunity in sequential influenza vaccination.
1. Nat Commun - published March 2, 2026
2. Wan XF, Guan M, Balamalaliyage P, Chen H, Prasai K, Alcala A, Driver J, Olivier AK, Gu W, Frymire C, Madrid DMC, Gao C, Wang C, Li T, Tunterak W, Yang Q, Ramesh A, Ali M, Smith D, Li L, Sant AJ, Hang J, Xie H, Zhou M, Tao YJ
Protein-Linker Co-engineering for Broad-Spectrum Antiviral Development against Enveloped Viruses.
1. ACS Mater Lett - published March 2, 2026
2. Wei L, Loynachan CN, Mathez G, Zhu Y, Liao S, Zwygart AC, Menin L, Tapparel C, Cagno V, Stellacci F
Structural characterization of the Cu(II)-NTA spin label on α-helices by X-ray crystallography and electron paramagnetic resonance.
1. Structure - published March 2, 2026
2. Besaw JE, Reichenwallner J, Chen EY, Hermet-Teesalu P, Tregubenko A, Kim K, Morizumi T, Ustav M Jr, Ernst OP
Structure and dynamics of 2x(CENP-A/H4)(2) octasome reveal a possible intermediate in centromeric chromatin.
1. Life Sci Alliance - published March 1, 2026
2. Ali-Ahmad A, Mors M, Carrer M, Li X, Bilokapić S, Halić M, Cascella M, Sekulić N
Application of differential scanning fluorimetry to X-ray protein crystallography.
1. IUCrJ - published March 1, 2026
2. Sato Y, Senda T
Microstructural analysis of the human ventricular myocardium in subjects with Type-II Diabetes.
1. Biochem Biophys Rep - published March 1, 2026
2. Keerthi H, Ramirez SP, Corral MM, Hernandez de Estrada I, Dorado ZN, Gobinath C, Esparza AE, Poon W, Joddar B
Crystal structure of carbon-nitrogen hydrolase from Helicobacter pylori G27.
1. Acta Crystallogr F Struct Biol Commun - published March 1, 2026
2. Srivastava A, Ayanlade JP, Suleiman L, Udell H, Abendroth J, Lorimer DJ, Edwards TE, Staker BL, Zigweid R, Subramanian S, Myler PJ, Chakafana G, Asojo OA
Breaking barriers: transitioning from X-ray crystallography to cryo-EM for structural studies.
1. Acta Crystallogr D Struct Biol - published March 1, 2026
2. Zafar H, Malone KL, Singh AK, Cianfrocco MA, Glass KC
Bias in the AlphaFold3 prediction of ligand-induced domain motion in enzymes.
1. Proc Natl Acad Sci U S A - published March 1, 2026
2. Yu H, Bekar-Cesaretli AA, Lazou M, Kozakov D, Joseph-McCarthy D, Vajda S