Member Publications

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146 Member Publications for December 2025

Dual Receptor Targeting Ensures Uptake and Anticancer Efficacy of Low-Density Lipoprotein-Docosahexaenoic Acid Nanoparticles Across Breast Cancer Cell Subtypes.
1. Breast Cancer (Dove Med Press) - published December 12, 2025
2. Bower J, Anwar A, Chaudhary J, Chen Z, Schumacher M, Debose-Boyd R, Corbin IR
C3 mutations and poor pegcetacoplan response in paroxysmal nocturnal hemoglobinuria.
1. Front Immunol - published December 12, 2025
2. Rodríguez de Córdoba S, Reparaz Suevos A, González Sanz S, Fernández FJ, Vega MC, Varela EC, Lada Colunga A, Vallejo Llamas JC, Gonzalez-Rodríguez AP
Atomic models of the Toxoplasma cell invasion machinery.
1. Nat Struct Mol Biol - published December 9, 2025
2. Zeng J, Fu Y, Qian P, Huang W, Niu Q, Beatty WL, Brown A, Sibley LD, Zhang R
Puromycin-sensitive aminopeptidase acts as an inhibitory auxiliary subunit of volume-regulated anion channels and regulates cGAMP transport.
1. Mol Cell - published December 9, 2025
2. Zheng W, Hagino T, Wang H, Cheng HY, Koylass N, Chen KH, Wang H, Mani S, Mondal AK, Twomey EC, Qiu Z
Emerging structural insights into PRC2 function in development and disease.
1. Trends Biochem Sci - published December 9, 2025
2. Bhat MY, Liu X
Serendipity and the slime mold: a visual survey of high molecular-weight protein assemblies reveals the structure of the polyketide synthase Pks16.
1. Mol Cell Proteomics - published December 9, 2025
2. Hoogerbrugge G, Keatinge-Clay AT, Marcotte EM
Insights into the AAV packaging mechanism: Cryo-EM Structure of the AAV2 Rep-Capsid Packaging Complex.
1. bioRxiv - published December 9, 2025
2. Kaelber JT, Barnakov V, Shen J, Hernandez K, Tarbox HJ, Khan A, Escalante CR
Multiplexed Analysis of Multicomponent Biomolecular Condensates without Any Tag.
1. J Am Chem Soc - published December 8, 2025
2. Pálfy G, Schmoll J, Pérez ME, Damberger FF, Han Y, Emmanouilidis L, Allain FH, Novakovic M
Design, Synthesis, and Evaluation of Novel Inhibitors of Aminoglycoside-Resistance 16S Ribosomal RNA Methyltransferases.
1. ChemMedChem - published December 8, 2025
2. Deprez BE, Dey D, Zelinskaya N, Csatary EE, Yang QW, Nie M, Conn GL, Wuest WM
Unraveling the Potential of Small Molecule Heparin Glycomimetics in Neuroregenerative Therapeutics.
1. J Am Chem Soc - published December 8, 2025
2. Özkan M, Cellot G, Pawar S, Sardana D, Barravecchia I, Ballerini L, Angeloni D, Micera S, Stellacci F
A modular platform to display multiple hemagglutinin subtypes on a single immunogen.
1. Elife - published December 8, 2025
2. Thornlow Lamson D, Nait Mohamed FA, Vu M, Maurer DP, Ronsard L, Lingwood D, Schmidt AG
CD44 cross-linking promotes Plasmodium falciparum invasion.
1. Nat Commun - published December 7, 2025
2. Kongsomboonvech AK, Scally SW, Le Guen Y, Valissery P, Salinas ND, Cowman AF, Tolia NH, Egan ES
Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A.
1. Commun Chem - published December 5, 2025
2. McBride CM, McCauley M, Harris NR, Amin S, Curtis BJ, Verhey-Henke L, Teklemichael AA, Oliphant EN, Dranchak P, Lev KL, Qu F, Snodgrass HM, Lewis JC, Inglese J, Su XZ, Pereira F, Sherman DH
Exploitation of phage Carin-5's own DNA polymerase to sequence its T-hypermodified genome.
1. Sci Rep - published December 5, 2025
2. Sieskind R, Missoury S, Bonhomme F, Nogaret P, Lucas-Staat S, Monot M, Skurnik M, Baudoux AC, Delarue M
Non-Catalytic Inhibitors of the p38/MK2 Interface: Repurposing Approved Drugs to Target Neuroinflammation in Alzheimer's Disease.
1. J Med Chem - published December 5, 2025
2. Hu M, Li A, Fleming P, Gralla J, Negrón Terón K, Zhou Y, Miller EJ, Beyett TS, Wen Z, Du Y, Fu H, Ivanov AA
Postoperative delirium in patients with free flap reconstruction after head and neck tumor surgery: influencing factors for severity and onset time, and a prediction model.
1. BMC Oral Health - published December 4, 2025
2. Liu ZX, Yu ZL, Chen GL, Gong P
Discovery of a small molecule TLR3 agonist adjuvant.
1. Nat Commun - published December 4, 2025
2. Lee B, Dong D, Nanishi E, Awad JM, Abedi KZ, Saito Y, Borriello F, Barman S, Brook B, Kelly A, Menon M, Marques-Mourlet C, Gupta MV, Lister I, Oh C, Lyskawa K, Goetz M, Walker K, Cheng WK, Brightman SE, Sharma P, O'Meara TR, Chew K, Vieira D, Ryff K, Sweitzer C, Thomas S, van Haren SD, Pettengill M, Seo HS, Dhe-Paganon S, Zhang W, Levy O, Dowling DJ
A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1.
1. Nat Commun - published December 4, 2025
2. Zhu Z, Chung YM, Alyamani M, Dai Y, McCarty KD, Roberts E, Sinha S, Li J, Li X, Gad EM, Zhou Z, Shi J, Burgess RA, Hargrove TY, Lepesheva GI, Guengerich FP, Auchus RJ, Sharifi N
The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin.
1. Science - published December 4, 2025
2. Carlson ES, Haslecker R, Lecchi C, Aguilar Ramos MA, Vennelakanti V, Honaker L, Stornetta A, Millán ES, Johnson BA, Kulik HJ, Balbo S, Villalta PW, D'Souza VM, Balskus EP
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis.
1. Cell - published December 4, 2025
2. Lorenz SM, Wahida A, Bostock MJ, Seibt T, Santos Dias Mourão A, Levkina A, Trümbach D, Soudy M, Emler D, Rothammer N, Woo MS, Sonner JK, Novikova M, Henkelmann B, Aldrovandi M, Kaemena DF, Mishima E, Vermonden P, Zong Z, Cheng D, Nakamura T, Ito J, Doll S, Proneth B, Bürkle E, Rizzollo F, Escamilla Ayala A, Napolitano V, Kolonko-Adamska M, Gaussmann S, Merl-Pham J, Hauck S, Pertek A, Orschmann T, van San E, Vanden Berghe T, Hass D, Maida A, Frenz JM, Pedrera L, Dolga A, Kraiger M, Hrabé de Angelis M, Fuchs H, Ebert G, Lenberg J, Friedman J, Scale C, Agostinis P, Zimprich A, Vogt-Weisenhorn D, Garrett L, Hölter SM, Wurst W, Glaab E, Lewerenz J, Popper B, Sieben C, Steinacker P, Zischka H, Garcia-Saez AJ, Tietze A, Ramesh SK, Ayton S, Vincendeau M, Friese MA, Wigby K, Sattler M, Mann M, Ingold I, Jayavelu AK, Popowicz GM, Conrad M
Rethinking what pLDDT really tells us about protein flexibility.
1. Structure - published December 4, 2025
2. Riccabona JR, Loeffler JR, Schoeder CT, Meiler J, Ward AB, Fernandez-Quintero M
Fission yeast Tpt1 is composed of tandem RNA 2'-phosphotransferase and Yae1 domains, both of which are essential for viability.
1. RNA - published December 3, 2025
2. Sarkar A, Schwer B, Shuman S
A system for high-throughput axonal imaging of induced pluripotent stem cell-derived human i(3)Neurons.
1. Mol Biol Cell - published December 3, 2025
2. Whittaker SAC, McKenna ED, Sarbanes SL, Fernandopulle MS, Ward ME, Roll-Mecak A
Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors.
1. Biochemistry - published December 3, 2025
2. Kuijer MB, Fulton CJ, Albert TL, Knobloch P, Wang J, Krumm BE, Che T, Varga BR, Majumdar S, Katritch V, Gumpper RH, Kenakin T, Huang XP, Roth BL
Post-vaccination SARS-CoV-2 neutralizing antibodies in pregnant women receiving biologics for inflammatory bowel disease.
1. PLoS One - published December 3, 2025
2. Leet DE, Jin J, Craik CS, Kattah MG, Long MD, Mahadevan U
Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation.
1. Nat Struct Mol Biol - published December 3, 2025
2. Bridgers JB, Carlström A, Sherpa D, Couvillion MT, Rovšnik U, Gao J, Wan B, Shao S, Ott M, Churchman LS
Saxiphilin functions as a 'toxin sponge' protein that counteracts the effects of saxitoxin poisoning.
1. bioRxiv - published December 3, 2025
2. Nixon SA, Zakrzewska S, Jang S, Huang K, Bara A, Chen Z, Goss DR, Park ER, Du Bois J, Minor DL Jr
Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV.
1. Cell Rep - published December 3, 2025
2. Qerqez AN, Hoffmann K, Lee AG, Pareek S, Hager K, Mishra AK, Delidakis G, Bentley K, Kerr-Jones L, Cabrera M, Nguyen T, Göttler RL, Chowdhury A, Kolb PL, Hengel H, Georgiou G, McLellan JS, Stanton RJ, Nguyen AW, Maynard JA
CD301b lectin expression in the breast tumor microenvironment augments tumor growth.
1. Res Sq - published December 3, 2025
2. Ozdilek A, Paschall AV, Nawaz Z, Niyas AMM, Avci FY
The gatekeepers of global health knowledge: A systematic review of diversity in editorial boards.
1. Glob Public Health - published December 3, 2025
2. El-Gamal S, Desjardins A, Kallesøe SAS, Paniello-Castillo B, Khan SF, Hassan HK, Othman R, Wyns A, Chenault G, Abbadi A, Atkinson B, Azeezat F, Usman AB, Ceballos KC, Chan A, Gupta S, Khorsand P, Li J, M R, Chabi SM, Patil P, Pigeolet M, Rendina C, Riaz MMA, Santamarta-Zamorano A, Singh P, Tatah L, Thondoo M, Oudah ASI, Wu KT, Dada S, van Daalen KR
Ornithine lipids from Akkermansia muciniphila are dynamically modulated in colitis and shape macrophage inflammatory responses.
1. Gut Microbes - published December 3, 2025
2. Selmi H, Walker A, Balas L, Lucio M, Klotz M, Jeridi A, Burrichter AG, Conti D, Chaffringeon L, Beinsteiner B, Jasnin M, Vanthuyne N, Durand T, Yildirim AÖ, Stecher B, Debarbieux L, Schmitt-Kopplin P
Molecular mechanism of substrate transport by human peroxisomal ABCD3.
1. Proc Natl Acad Sci U S A - published December 3, 2025
2. Gupta M, Khandelwal NK, Seka DJ, Balasubramani SG, Dickinson MS, Myasnikov A, Echeverria I, Stroud RM
Energetic and structural control of polyspecificity in a multidrug transporter.
1. Proc Natl Acad Sci U S A - published December 3, 2025
2. Miller ST, Henzler-Wildman KA, Raman S
A new metabolic path in type 3 rickets.
1. FEBS J - published December 3, 2025
2. Senda T, Hirota Y
Type IV Secretion Systems: Reconciling Diversity Through a Unified Nomenclature.
1. FEMS Microbiol Rev - published December 3, 2025
2. Christie PJ, Waksman G, Berntsson RP, Soler N, Leblond-Bourget N, Douzi B
Affinity maturation and light-chain-mediated paratope diversification anticipates viral evolution.
1. Cell Rep - published December 3, 2025
2. Dingus J, Yoo DK, Kumar S, Wang Y, Kibria MG, Saghaei S, Allahyari Z, Chen JW, Caputo NM, Hwang J, Chen B, Wesemann DR
Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade.
1. Cell Rep - published December 3, 2025
2. Bell B, Jaramillo-Granada AM, Orlin DJ, Weng WH, Wen H, Sotomayor M, Chesler AT, Baker ML, Cordero-Morales JF, Vásquez V
The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling.
1. Proc Natl Acad Sci U S A - published December 2, 2025
2. Bandekar SJ, Dintzner EE, Leon K, Kordon SP, Slezak T, Cechova K, Vafabakhsh R, Araç D
ATG2 is a triglyceride transfer protein.
1. Proc Natl Acad Sci U S A - published December 2, 2025
2. Korfhage JL, Elhan H, Wan N, Lu Y, Kauffmann L, Pilli G, Fuller DM, Rios AM, Reinisch KM, Maddipati KR, Thiam AR, Melia TJ
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier.
1. Nat Cell Biol - published December 2, 2025
2. Kozai T, Fernandez-Martinez J, Kapinos LE, Gallardo P, van Eeuwen T, Saladin M, Eliasian R, Mazur A, Zhang W, Tempkin J, Panatala R, Delgado-Izquierdo M, Escribano-Marin R, Feng Q, Lin C, Sali A, Chait BT, Raveh B, Veenhoff LM, Rout MP, Lim RYH
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms.
1. Annu Rev Biophys - published December 2, 2025
2. Villalta A, Weerawarana SR, Nosella ML, Hamel NL, Luger K
Enhanced S-Palmitoylated Protein Detection by Mild Nonionic Detergent in Proteomic Workflow.
1. J Am Soc Mass Spectrom - published December 2, 2025
2. Kim H, Issara-Amphorn J, Yoon S, Banerjee A, Nita-Lazar A
Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale.
1. Nat Methods - published December 2, 2025
2. Kiselev R, Brady RA, Modak A, Cruz-Navarrete FA, Alejo JL, Terry DS, Altman RB, Asher WB, Javitch JA, Blanchard SC
Recruiting ESCRT to single-chain heterotrimer peptide MHCI releases antigen-presenting vesicles that stimulate T cells selectively.
1. Proc Natl Acad Sci U S A - published December 2, 2025
2. Olson BA, Huey-Tubman KE, Mao Z, Hoffmann MAG, Bjorkman PJ, Murray RM, Mayo SL
Crystallographic Ensembles Reveal the Structural Basis of Binding Entropy in SARS-CoV2 Macrodomain.
1. bioRxiv - published December 2, 2025
2. Seo L, Farran I, Aslam A, Li X, Jaishankar P, Ashworth A, Fraser JS, Renslo AR, Wankowicz SA
A ribosome-bound pseudoknot in the HCV coding region stimulates viral growth by tuning viral translation.
1. Cell Rep - published December 2, 2025
2. Wan H, Jang H, Xu L, Abdallah KS, Gilbert WV, Pyle AM
Non-equilibrium snapshots of ligand efficacy at the μ-opioid receptor.
1. Nature - published December 2, 2025
2. Robertson MJ, Modak A, Papasergi-Scott MM, Hu M, Peroto MC, Varga BR, Majumdar S, Kalathur R, Blanchard SC, Skiniotis G
The essential co-chaperone Sgt1 regulates client dwell time in the Hsp90 chaperone cycle.
1. Mol Cell - published December 2, 2025
2. Engler S, Delhommel F, Dodt C, Lopez A, Faust O, Elimelech A, Napolitano V, Popowicz GM, Rosenzweig R, Sattler M, Buchner J
Hepatic adaptation to chronic metabolic stress primes tumorigenesis.
1. Cell - published December 2, 2025
2. Tzouanas CN, Shay JES, Sherman MS, Rubin AJ, Mead BE, Dao TT, Tao J, Lehrich BM, Eng G, Patterson-Fortin J, Butzlaff T, Mana MD, Kolb KE, Walesky C, Pepe-Mooney BJ, Smith CJ, Prakadan SM, Ramseier ML, Tong YE, Joung J, Chi F, McMahon-Skates T, Winston CL, Jeong WJ, Aney KJ, Chen E, Nissim S, Zhang F, Deshpande V, Monga SP, Lauer GM, Goessling W, Yilmaz ÖH, Shalek AK
Precision Labeling of Native Antibodies with Lock Coupling.
1. J Am Chem Soc - published December 2, 2025
2. Liu Y, Nadig I, Mehta AS, Chuo SW, Ho YH, Tyler J, Craik CS, Anwar M, Cohen BE
Investigation of Peptide Binding to Fibrin for the Design of Targeted Molecular Imaging Agents.
1. Langmuir - published December 2, 2025
2. Ostrovsky N, Ragatz A, Wong JY, Joseph-McCarthy D
Nanobodies against Clostridioides difficile CDTb provide a toolkit for potent toxin neutralization and highly sensitive quantitation.
1. J Biol Chem - published December 2, 2025
2. Nabukhotna K, Kroh HK, Anderson DM, Cano Rodríguez R, Shupe JA, McGresham M, O'Neale CVT, Shrem RA, Wadzinski BE, Schey KL, Spiller BW, Lacy DB
Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP-1 Transcription Factor ΔFOSB.
1. J Biol Chem - published December 2, 2025
2. McNeme S, Yim YY, Kumar A, Li Y, Hughes B, St Romain CP, Aglyamova G, Chen J, Nguyen ND, Fan S, Stephens GS, Zhao WN, Kruzshak S, Estill M, Brener C, Tofani S, Kumar A, Chen EP, Takatka N, Robison AJ, Chen H, Powell RT, Haggarty SJ, Stephan C, Nestler EJ, Chin J, Machius M, Zhou J, Rudenko G
A reversible feedback mechanism regulating mitochondrial heme synthesis.
1. J Biol Chem - published December 2, 2025
2. Chitrakar I, Roberson AB, Ayres-Galhardo PH, Brown BL
New Insights of Muraymycin A1 and Its Analogs as DPAGT1 Inhibitors.
1. Bioorg Chem - published December 2, 2025
2. Mitachi K, Daria D, Kirsh JM, Effah W, Narayanan R, Clemons WM Jr, Kurosu M
Molecular impacts of Meier-Gorlin syndrome mutations on human origin licensing.
1. J Biol Chem - published December 2, 2025
2. Yang R, Hunker O, Kim J, Bleichert F
Identifying membrane-bound transcriptional regulatory proteins from rare but evolutionarily conserved domain combinations.
1. bioRxiv - published December 2, 2025
2. Lee M, Jang Y, Guo Q, Kim J, Marcotte EM
Cryo-EM structure of N-glycosylated Pomacea canaliculata hemocyanin provides insights into its role in the immune response of gastropods.
1. FEBS J - published December 2, 2025
2. Brola TR, Chiumiento IR, Ituarte S, Benítez GI, Gragera M, Carazo JM, Heras H, Otero LH, Dreon MS
HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2.
1. Sci Rep - published December 2, 2025
2. Alvarez F, Larrous F, Mechaly A, Bardiaux B, Goor Q, Haouz A, Séon-Méniel B, de Sousa RA, Bourg S, Desmaële D, Figadère B, Wolff N, Munier-Lehmann H, Caillet-Saguy C
Proteome-Wide Analysis of Palmitoylated Proteins in Macrophages Reveals Novel Insights Into Early Immune Signaling.
1. Proteomics - published December 2, 2025
2. Kim H, Issara-Amphorn J, Yoon SH, Banerjee A, Nita-Lazar A
PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates.
1. Nat Chem Biol - published December 2, 2025
2. Zhao Z, Xu W, Feng EY, Cao S, Hermoso-López A, Peña-Vega P, Lloyd HC, Porter AKD, Guzmán M, Zheng N, Woo CM
Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly.
1. Cell - published December 2, 2025
2. Yu Z, Sathyanarayana P, Liu C, Tan JMJ, Yang P, Das B, Hu S, Fan X, Ji C, Weller SK, Shekhar M, Coen DM, Kranzusch PJ, Loparo JJ, Abraham J
PIP2 Binding at Allosteric Site Blocks Activation in Human Rod CNG Channels.
1. bioRxiv - published December 2, 2025
2. Park T, Nimigean CM
Full-Length Structure and Heme Binding in the Transcriptional Regulator HcpR.
1. ACS Omega - published December 2, 2025
2. Belvin BR, Musayev FN, Escalante CR, Lewis JP
The cobalamin-binding domain of cobalamin-dependent radical S-adenosylmethionine enzymes: Familiarity in unfamiliar places.
1. J Inorg Biochem - published December 2, 2025
2. Avalos DM, Drennan CL
Evolution of the RNA alternative decay cis element into a high-affinity target for the immunomodulatory protein Roquin.
1. RNA Biol - published December 1, 2025
2. Tants JN, Friedrich K, Neumann J, Schlundt A
PfCSP-ferritin nanoparticle malaria vaccine antigen formulated with aluminum-salt and CpG 1018® adjuvants: Preformulation characterization, antigen-adjuvant interactions, and mouse immunogenicity studies.
1. Hum Vaccin Immunother - published December 1, 2025
2. Hickey JM, Sharma N, Fairlamb M, Doering J, Adewunmi Y, Prieto K, Costa G, Wizel B, Levashina EA, Mantis NJ, Julien JP, Joshi SB, Volkin DB
The crystal structure of the toxin EspC from enteropathogenic Escherichia coli reveals the mechanism that governs host cell entry and cytotoxicity.
1. Gut Microbes - published December 1, 2025
2. Pilapitiya AU, Hor L, Pan J, Wijeyewickrema LC, Pike RN, Leyton DL, Paxman JJ, Heras B
Building a potent TREM2 agonistic, biparatopic, common light chain antibody.
1. MAbs - published December 1, 2025
2. da Silva Almeida A, Geddie ML, Bhate A, Quan C, Arndt JW, Jiao Y, Santoro JC, Noiman L, Vijayakumar R, Sanchez-Salazar J, Datta A, Antognetti G, Hartana CA, Wang XF, Smith BA, Bartlett D, Duncan D, Liu CC, Otero Gutierrez K, Cameron TO, Koirala S, Cooke HA
Relationship between baseline right ventricular systolic function and left ventricular recovery at six-months of follow up among women with peripartum cardiomyopathy in Uganda.
1. Int J Cardiol Heart Vasc - published December 1, 2025
2. Nabbaale J, Okello E, Nakimuli A, Chakafana G, Sliwa K
IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope.
1. Cancer Sci - published December 1, 2025
2. Ogawa-Iio A, Takeuchi K, Shigemi K, Genoveso MJ, Niitsu H, Koh I, Ota Y, Yamane K, Hinoi T, Osaka N, Oshima M, Ishikawa T, Mizuno T, Natsumeda M, Tateishi K, Hashizume R, Osuka S, Goyama S, Yasuda T, Senda T, Sasaki AT
Genome-replicating HC-AdV: A novel high-capacity adenoviral vector class featuring enhanced in situ payload expression.
1. Mol Ther Methods Clin Dev - published December 1, 2025
2. Kolibius J, Weiss F, Freitag PC, Plückthun A
CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection.
1. Acta Crystallogr F Struct Biol Commun - published December 1, 2025
2. Schäfer JH, Calza A, Hom K, Damodar P, Peng R, Bogdanović N, Lander GC, Stagg SM, Cianfrocco MA
SINE compounds activate exportin 1 degradation through an allosteric mechanism.
1. Nat Chem Biol - published December 1, 2025
2. Wing CE, Fung HYJ, Kwanten B, Cagatay T, Niesman AB, Jacquemyn M, Gharghabi M, Permentier B, Shakya B, Nandi R, Ready JM, Kashyap T, Shacham S, Landesman Y, Lapalombella R, Daelemans D, Chook YM
Gluing the allosteric way.
1. Nat Chem Biol - published December 1, 2025
2. Schneider LA, Bendel AM, Baur R, Thomä NH
DNA topoisomerase I acts as supercoiling sensor for bacterial transcription elongation.
1. Nat Struct Mol Biol - published December 1, 2025
2. Vidmar V, Borde C, Bruno L, Miropolskaya N, Takacs M, Batisse C, Saint-André C, Zhu C, Espéli O, Lamour V, Weixlbaumer A
A protective and heterosubtypic antibody lineage targeting the influenza A virus neuraminidase active site.
1. J Clin Invest - published December 1, 2025
2. Sornberger TA, Wolters RM, Gilchuk IM, Myers L, Binshtein E, Irving R, Chen EC, Gilchuk P, Nargi RS, Sutton RE, Howard BN, Handal LS, Trivette A, Webb KE, Kona C, Villalobos E, Williamson LE, Crowe JE Jr, Zost SJ
CD8(+) T cell stemness precedes post-intervention control of HIV viremia.
1. Nature - published December 1, 2025
2. Kiani Z, Urbach JM, Wisner H, Olatotse MJ, Chang DY, Acklin JA, Piechocka-Trocha A, Bonheur N, Khatri A, Lichterfeld M, Gunst JD, Søgaard OS, Caskey M, Nussenzweig MC, Walker BD, Collins DR
Correlates of HIV-1 control after combination immunotherapy.
1. Nature - published December 1, 2025
2. Peluso MJ, Sandel DA, Deitchman AN, Kim SJ, Dalhuisen T, Tummala HP, Tibúrcio R, Zemelko L, Borgo GM, Singh SS, Schwartz K, Deswal M, Williams MC, Hoh R, Shimoda M, Narpala S, Serebryannyy L, Khalili M, Vendrame E, SenGupta D, Whitmore LS, Tisoncik-Go J, Gale M Jr, Koup RA, Mullins JI, Felber BK, Pavlakis GN, Reeves JD, Petropoulos CJ, Glidden DV, Spitzer MH, Gama L, Caskey M, Nussenzweig MC, Chew KW, Henrich TJ, Yukl SA, Cohn LB, Deeks SG, Rutishauser RL
RAD51 D-loop structures reveal the mechanism of eukaryotic RAD51-mediated strand exchange.
1. Nat Commun - published December 1, 2025
2. Luo SC, Yang CH, Yeh HY, Lin CW, Yeh MC, Chi P, Ho MC
Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants.
1. Dev Cell - published December 1, 2025
2. Sánchez de Medina Hernández V, Nava-García MM, Bianchi A, Clavel M, Papareddy RK, Benchalel L, Andreev VI, Mathur V, Mohseni A, García-León M, Gao P, de la Concepción JC, Picchianti L, Grujic N, Kobylinska R, Abdrakhmanov A, Duvergé H, Anand G, Leibrock N, Ma J, Raffeiner M, Crawford TS, Argirò L, Matuszkiewicz M, Wun CL, Kanne JV, Meinhart A, Roitinger E, Bäurle I, Kang BH, Petersen M, Üstün S, Kulathu Y, Clausen T, Ramundo S, Dagdas Y
PROFILING THE TRPV4 ANKYRIN REPEAT DOMAIN INTERACTOME AND ITS DISRUPTION BY NEUROMUSCULAR DISEASE-CAUSING MUTATIONS.
1. J Biol Chem - published December 1, 2025
2. Loder AK, Kosmanopoulos GP, Aisenberg WH, Cox E, Meeker AR, Blackshaw S, Gaudet R, Hellmich UA, McCray BA, Sumner CJ, Sullivan JM
SRC at the Crossroads of KRAS Inhibitor Resistance: Mechanisms and Therapeutic Opportunities.
1. Cancer Lett - published December 1, 2025
2. Tian H, Zhao D, Zhou Z, Kim A, Huang H, Lee YJ, Qu Z, Kang R, Zeh HJ, Westover KD, Song X
The Specification and Functional Maturation of Sub-Cerebral Projection Neurons Derived from Human Induced Pluripotent Stem Cells.
1. Stem Cells Dev - published December 1, 2025
2. Jordan Z, Singh A, Kattapong-Graber S, Goswami S, Sanjana NE, Zuccaro E, Zhang F, Eggan K, Hsieh J, Hermann BP, Hebert JM, Maroof AM
Postpartum lipid dysregulation in African American women who experienced cardiometabolic complications of pregnancy.
1. iScience - published December 1, 2025
2. Maner-Smith K, Chen CY, Hou Z, Gulbin XL, Ahn J, Ortlund EA, Dunlop AL, Ferranti E
A dendritic guidance receptor functions in both ligand dependent and independent modes.
1. PLoS Genet - published December 1, 2025
2. Reddy AR, Machera SJ, Cook ZT, Deng H, Nawrocka WI, Özkan E, Shen K
Vinyl ether maleic acid block copolymers: a versatile platform for tunable self-assembled lipid nanodiscs and membrane protein characterization.
1. Polym Chem - published December 1, 2025
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Potent neutralization by antibodies targeting the MPXV A28 protein.
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Decreased cytoplasmic crowding via inhibition of ribosome biogenesis can trigger Candida albicans filamentous growth.
1. Nat Microbiol - published December 1, 2025
2. Serrano A, Puerner C, Chevalier L, Plumb E, Elferich J, Diggs S, Sinn LR, Grigorieff N, Ralser M, Delarue M, Bassilana M, Arkowitz RA
Provider perceptions and experiences integrating depression treatment into chronic healthcare services in Neno District, Malawi: a qualitative study.
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The molecular mechanism of fluoride export by the eukaryotic fluoride channel FEX.
1. Nat Commun - published December 1, 2025
2. Kang CY, An M, Heidari S, Torabifard H, Ohi MD, Stockbridge RB
General trends in the calnexin-dependent expression and pharmacological rescue of clinical CFTR variants.
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Structural and immunological characterization of the H3 influenza hemagglutinin during antigenic drift.
1. Nat Commun - published December 1, 2025
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Autoregulation of the MET receptor tyrosine kinase by its intracellular juxtamembrane domain.
1. Biochem J - published December 1, 2025
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Structural insights into GM4951 as a lipid droplet GTPase regulating hepatic lipid metabolism.
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Asymmetrically glycosylated IgG1 antibodies are universal and drive human disease.
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Development of a Recombinant Single-Cycle Influenza Viral Vector as an Intranasal Vaccine against SARS-CoV-2 and SARS-like Betacoronaviruses.
1. bioRxiv - published December 1, 2025
2. Munro J, Melnyk D, Afzal M, Schimanski L, Cohen AA, Keeffe JR, Bjorkman PJ, James WS, Townsend AR, Tan TK
A single vesicle fluorescence microscopy platform to quantify phospholipid scrambling.
1. bioRxiv - published December 1, 2025
2. Veit S, Dearden GI, Menon KM, Noor F, Menon I, Morizumi T, Ernst OP, Menon AK, Pomorski TG
Discovery of Oxyacanthine Dihydrochloride Monohydrate Polymorphs from Obfuscated Samples by Microcrystal Electron Diffraction.
1. ChemMedChem - published December 1, 2025
2. Lin J, Paz O, Unge J, Gonen T
A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity.
1. Nat Commun - published December 1, 2025
2. Tsujino S, Tsuda M, Deguchi S, Ito J, Taha TY, Nasser H, Wang L, Rosecrans J, Suzuki R, Suzuki S, Yoshimatsu K, Ott M, Ikeda T, Sato K, Takayama K, Tanaka S, Tamura T, Fukuhara T, Genotype to Phenotype Japan (G2P-Japan) Consortium
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1. Nat Commun - published December 1, 2025
2. Chen J, Hu L, Vernuccio R, Shi N, Tian J, Zhang Y, Tian S, Cao X, Ha Z, Lu J, Battini L, Raynal B, Haouz A, Xue J, Cai Q, Zhao Y, Lu Y, Smith GL, Xie Y, Lu H, Guardado-Calvo P, Zhang P, Zhang R
DNA nanodevice for analysis of force-activated protein extension and interactions.
1. Nat Nanotechnol - published December 1, 2025
2. Zhou K, Chung M, Pandey S, Cheng J, Powell JT, Yan Q, Liu J, Xiong Y, Schwartz MA, Lin C
NMR Spectral Alignment Utilizing a CryoEM Motion Correction Algorithm.
1. Anal Chem - published December 1, 2025
2. Hemme CA, Warmuth OA, Wang S, Williams CG, Thome A, Mueller LJ, Rienstra CM, Grant T
The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex.
1. Nat Commun - published December 1, 2025
2. Notti RQ, Yi F, Heissel S, Bush MW, Molvi Z, Das P, Molina H, Klebanoff CA, Walz T
Author Correction: Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain.
1. EMBO J - published December 1, 2025
2. Dorr A, Kiermer V, Pedal A, Rackwitz HR, Henklein P, Schubert U, Zhou MM, Verdin E, Ott M
The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling.
1. Sci Signal - published December 1, 2025
2. Jamaluddin A, Wyatt RA, Lee J, Dowsett GKC, Tadross JA, Broichhagen J, Yeo GSH, Levitz J, Gorvin CM
Demonstration of in vivo efficacy, cryo-EM-epitope identification, and breadth of two anti-alphavirus bispecific single domain antibodies.
1. J Virol - published December 1, 2025
2. Gardner CL, Pletnev S, Liu JL, Anderson GP, Shriver-Lake LC, Bylund T, Green C, Stephens T, Sutton MS, Tsybovsky Y, Roederer M, Kwong PD, Zhou T, Goldman ER, Burke CW
Transient hepatic reconstitution of trophic factors enhances aged immunity.
1. Nature - published December 1, 2025
2. Friedrich MJ, Pham J, Tian J, Chen H, Huang J, Kehl N, Liu S, Lash B, Chen F, Wang X, Macrae RK, Zhang F
In vivo efficacy of combined human broadly neutralizing antibodies against hepatitis B virus.
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Scalable cyberinfrastructure for experimental NMR data.
1. Sci Data - published December 1, 2025
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Segmented filamentous bacteria undergo a structural transition at their adhesive tip during unicellular to filament development.
1. Nat Commun - published December 1, 2025
2. Cruz AR, Wimmer BH, Teo TH, Pehau-Arnaudet G, Winter JM, Gazi AD, Lafaye P, Brier S, Legrand A, Dubrovsky-Gaupp A, Bérard M, Aymé G, Sartori-Rupp A, Medalia O, Schnupf P
Enantioselective protein affinity selection mass spectrometry (E-ASMS).
1. Nat Commun - published December 1, 2025
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Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo.
1. J Med Chem - published December 1, 2025
2. Jaishankar P, Correy GJ, Matsui Y, Togo T, Rachman MM, Stevens MGV, Hantz ER, Zheng J, Diolaiti ME, Montano M, Taha TY, Rosecrans J, Pampel J, Krogan NJ, Shoichet BK, Ashworth A, Ott M, Fraser JS, Renslo AR
Phenotypic Variability and Paternal Inheritance of a CHD8 Variant Causing Intellectual Developmental Disorder With Autism and Macrocephaly Confirmed by Epigenetic and Structural Analyses.
1. Mol Genet Genomic Med - published December 1, 2025
2. Furuta Y, Ezell KM, Hamid R, Cogan JD, Cassini TA, Rives L, McMinn A, Shah S, Peltier AC, Layfield S, Fletcher RS, Tedder ML, Louie RJ, Lee JA, Kerkhof J, Rzasa J, Sadikovic B, Al Mamun A, Sheehan JH, Moth CW, Meiler J, Vawter-Lee M, Mendoza-Sengco PM, Holzen JB, Pruthi S, Phillips JA 3rd, Tinker RJ, Undiagnosed Diseases Network
Superwater as a generative AI framework to predict water molecule positions on protein structures.
1. Commun Chem - published December 1, 2025
2. Kuang X, Liu YL, Lin X, Spencer-Smith J, Derr T, Wu Y, Bitter H, Hu Y, Meiler J, Su Z
Alan G. Marshall: (Fourier) Transforming Analytical Chemistry and Biochemistry.
1. Cell Biochem Biophys - published December 1, 2025
2. Kiran S, Li X, Berliner LJ, Narayan P, Narayan M
BGC-MAC and BGC-MAP: Attention-Based Models for Biosynthetic Gene Cluster Classification and Product Matching.
1. J Chem Inf Model - published December 1, 2025
2. Lu K, Li M, Geng H, Xu W, Chen M, Fu TM, Luesch H, Ding Y, Xie WJ
Conformational Trajectory of the Molecular Chameleon Grazoprevir from Formulation to Target-Bound.
1. Chemistry - published December 1, 2025
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Broad-Spectrum Peptidomimetic Inhibitors of Norovirus and Coronavirus 3C-like Proteases.
1. ACS Infect Dis - published December 1, 2025
2. Brimble MA, Stubbing LA, Hermant YO, Yang SH, Hubert JG, Pearl ES, McSweeney AM, Young VL, Campbell AC, Opel-Reading HK, McKenzie-Goldsmith GM, Putha L, Mortuza R, Wang H, Hurst BL, Julander J, Harris LD, Krause KL, Ward VK
Structural Basis for Substrate Recruitment and Catalytic Ubiquitin Transfer by the E2/E3 Hybrid Enzyme UBE2O.
1. J Biol Chem - published December 1, 2025
2. Kordic D, Williams TL, Deszcz L, Ehrmann JF, Arnese R, Schleiffer A, Clausen T, Meinhart A
Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context.
1. J Mol Biol - published December 1, 2025
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Lessons learned from Canadian family physicians deprescribing medications in older adults - a five-year retrospective review of medico-legal cases.
1. BMC Geriatr - published December 1, 2025
2. Smith JD, Sadowski CA, Lee JY, Bernard C, Casey GM, Larivière KE, Finestone PJ, Zhang C, Garber GE
Mechanism of cotranslational modification of histones H2A and H4 by MetAP1 and NatD.
1. Sci Adv - published December 1, 2025
2. Yudin D, Jaskolowski M, Fan Z, Burg N, Chandrasekar S, Lentzsch AM, Scaiola A, Bothe A, Deuerling E, Gamerdinger M, Shan SO, Ban N
Structural insights into zinc piracy by Neisseria gonorrhoeae to overcome nutritional immunity.
1. Structure - published December 1, 2025
2. Gheinani PT, Bera A, Stoudenmire-Saylor J, Lien Y, Harrison SA, Criss A, Chazin WJ, Noinaj N, Cornelissen CN
A Plasmodium-derived nanoparticle vaccine elicits sterile protection against malaria in mice.
1. Nat Microbiol - published December 1, 2025
2. Shi D, Ma R, Gupta R, Dickey TH, Patel PN, Salinas ND, Tang WK, Queen A, Singleton M, Delbe N, Conteh S, Lambert LE, Duffy PE, Tolia NH
Streptococcus pneumoniae S protein activates PBP1a to regulate peptidoglycan remodelling and cell division.
1. Nat Microbiol - published December 1, 2025
2. Millat H, Falcou C, Lenoir C, Briggs NS, Stone J, Garcia PS, Manuse S, Cluzel C, Zapun A, Morlot C, Roper DI, Ducret A, Grangeasse C
Structural and Biochemical Insights into the Broad-Spectrum TET enzyme from Methanocaldococcus jannaschii reveals the basis of substrate specificity in M42 aminopeptidases.
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Amyloid-mediated RNA uptake by sperm for embryonic delivery.
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IHMValidation: Assessment of Integrative Structure Models Deposited to the Protein Data Bank.
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The role of kinase domain dimerization in EGFR activation.
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Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii.
1. Mol Cell - published December 1, 2025
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DNA binding and lesion recognition by the bacterial interstrand DNA crosslink glycosylase AlkX.
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Mechanism of NanR transcriptional activation of sialic acid metabolism in Streptococcus pneumoniae.
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An integrated workflow for structural virology with a 100 keV electron microscope.
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TRPXv2.0: superfast, parallel compression of diffraction patterns and images, with native Python and HDF5 support.
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Basic Science and Pathogenesis.
1. Alzheimers Dement - published December 1, 2025
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Basic Science and Pathogenesis.
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Fluorinated HIV-1 protease inhibitors containing chiral hydroxyethylbenzene and indanol as P2' ligands with potent activity against drug-resistant variants.
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Structures of bacterial and human phosphoglycosyltransferases bound to a common inhibitor inform selective therapeutics.
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Capsid flexibility during Ty1 virus-like particle assembly.
1. bioRxiv - published December 1, 2025
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Antibody Mediated Diversification of Primary and Secondary Immune Responses.
1. bioRxiv - published December 1, 2025
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Atg23 Interacts With Both the N- and C-termini of Atg9 Via a Hydrophobic Binding Pocket.
1. bioRxiv - published December 1, 2025
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Recent Advances in Endolysin Engineering.
1. Antibiotics (Basel) - published December 1, 2025
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An AKR1C3-activated kinase inhibitor prodrug.
1. RSC Chem Biol - published December 1, 2025
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