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133 Member Publications for November 2025

Deacetylation of HSC70 by SIRT2 promotes chaperone mediated autophagy.
1. Autophagy Rep - published November 19, 2025
2. Ahn B, Chen W, Shi W, Shrestha R, Hu F, Lin H
Single-residue engineering of lambda (λ) antibody light chains reduces conformational flexibility and enhances thermal stability.
1. Comput Struct Biotechnol J - published November 17, 2025
2. Jewel Y, Young T, Park M, Ly K, Gonzalez A, Mallett TC, Williams JC
Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions.
1. J Virol - published November 12, 2025
2. Muthuraman K, Jackman M, Liang Y, Garrett ME, Cui H, Nguyen LVH, Ivanochko D, Ye C, Pino PA, Hicks A, Maingot B, Yusko E, Benzeno S, Martínez-Sobrido L, Torrelles JB, Gilbert AE, Rubin BER, Keitany G, Jetha A, Julien J-P
Retraction Note: Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
1. BMC Complement Med Ther - published November 8, 2025
2. Ardah MT, Ghanem SS, Abdulla SA, Lv G, Emara MM, Paleologou KE, Vaikath NN, Lu JH, Li M, Vekrellis K, Eliezer D, El-Agnaf OMA
Multifunctionally diverse alkaline phosphatases of Alteromonas drive the phosphorus cycle in the ocean.
1. Nat Commun - published November 7, 2025
2. Saavedra DEM, González JM, Klaushofer K, Breyer E, Afjehi-Sadat L, Bulgheresi S, Liao L, Dong X, Patrick WM, Baltar F
Functional Profiling of KCNE1 Variants Informs Population Carrier Frequency of Jervell and Lange-Nielsen Syndrome Type 2.
1. Circ Genom Precis Med - published November 7, 2025
2. Vanoye CG, Desai RR, John JD, Hoffman SC, Fink N, Zhang Y, Venkatesh OG, Roe J, Adusumilli S, Jairam NP, Sanders CR, Gordon AS, George AL Jr
Ultra-large library screening with an evolutionary algorithm in Rosetta (REvoLd).
1. Commun Chem - published November 7, 2025
2. Eisenhuth P, Liessmann F, Moretti R, Meiler J
Structural basis of herpesvirus helicase-primase inhibition by pritelivir and amenamevir.
1. Sci Adv - published November 7, 2025
2. Baranovskiy AG, He Q, Suwa Y, Morstadt LM, Babayeva ND, Lim CJ, Tahirov TH
Optimized conditions for GTP loading of Ras.
1. J Biol Chem - published November 7, 2025
2. Vish KJ, Paul ME, Rollins AP, Boggon TJ
Protein Engineering of Biosynthetic Enzymes Unlocks Libraries of Bioactive Tilimycin Analogs.
1. ACS Catal - published November 7, 2025
2. MacDonald MR, Hasselbeck J, Gulick AM
Subnanometer-resolution Structural Determination of Hemagglutinin from Cryo-electron Tomography of Influenza Viruses.
1. J Vis Exp - published November 7, 2025
2. Huang QJ, McDaniel CN, Griffith AA, Schiffer CA, Somasundaran M
Human coronavirus HKU1 neutralization by glycan receptor mimicry.
1. bioRxiv - published November 7, 2025
2. Feng Z, Kose N, Moreira FR, Kimpel ALM, Copps J, Suryadevara N, Jackson DJ, Gern JE, Wilson IA, Li S, de Vries RP, Baric RS, Bangaru S, Crowe JE Jr, Ward AB
Axonemal dynein contributions to flagellar beat types and waveforms.
1. bioRxiv - published November 7, 2025
2. Fochler S, Doran MH, Beneke T, Smith J, Fort C, Walker BJ, Brown A, Gluenz E, Wheeler RJ
Elucidating the crystal structure of botulinum neurotoxin type A: a personal remembrance.
1. J Neural Transm (Vienna) - published November 6, 2025
2. Lacy DB
Novel Dimeric Capsid Assembly Modulators as a Unique Class of Highly Potent Anti-HBV Agents.
1. J Med Chem - published November 6, 2025
2. Amblard F, Chen Z, Kra K, Patel D, Bassit L, Gargowitsch L, Degrouard J, Rat V, Arteni AA, Matthews L, Ravichandran SM, Jiang A, Athanasiadis A, Dangas G, Abate M, Tresset G, Pronost J, Salman M, Verma K, Kirby KA, Michailidis E, Rocquigny H, Durantel D, Bressanelli S, Sarafianos SG, Schinazi RF
Author Correction: Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against evading flg22 epitopes.
1. Nat Plants - published November 6, 2025
2. Zhang S, Liu S, Lai HF, Bender KW, Kim G, Caflisch A, Zipfel C
An updated evolutionary classification of CRISPR-Cas systems including rare variants.
1. Nat Microbiol - published November 6, 2025
2. Makarova KS, Shmakov SA, Wolf YI, Mutz P, Altae-Tran H, Beisel CL, Brouns SJJ, Charpentier E, Cheng D, Doudna J, Haft DH, Horvath P, Moineau S, Mojica FJM, Pausch P, Pinilla-Redondo R, Shah SA, Siksnys V, Terns MP, Tordoff J, Venclovas Č, White MF, Yakunin AF, Zhang F, Garrett RA, Backofen R, van der Oost J, Barrangou R, Koonin EV
Mouse-adapted SARS-CoV-2 Omicron BA.5 infection induces post-acute lung fibrosis in BALB/c mice.
1. J Virol - published November 6, 2025
2. Powers JM, Leist SR, Suryadevara N, Zost SJ, Binshtein E, Abdelgadir A, Mallory ML, Edwards CE, Gully KL, Hubbard ML, Zweigart MR, Bailey AB, Sheahan TP, Crowe JE Jr, Montgomery SA, Harkema JR, Baric RS
An ATP-gated molecular switch orchestrates human messenger RNA export.
1. Nature - published November 6, 2025
2. Hohmann U, Graf M, Tirián L, Pacheco-Fiallos B, Schellhaas U, Fin L, Handler D, Philipps AW, Riabov-Bassat D, Faraway RW, Pühringer T, Szalay MF, Roitinger E, Brennecke J, Plaschka C
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis.
1. Mol Cell - published November 6, 2025
2. Zheng F, Yu Z, Zhuang J, Vannur L, Nickols W, Wang Y, Li L, Tan SJO, Yoo S, Cheng Y, Zhou C
Enhanced HIV-1 Control After Antibody Therapy is Associated with Autologous Antibodies and Reservoir Clearance in the RIO trial.
1. medRxiv - published November 6, 2025
2. Fumagalli MJ, Kaczynska A, Allombert M, Lopes-Ribeiro Á, de Oliveira Silva M, Hernandez BJ, Lavine C, Espinosa SM, Brown H, Box H, Falaschetti E, Cherrill LR, Elliott T, Lee M, Fox J, Pett S, Clarke A, Uriel A, Sogaard O, Sutherland R, Boffito M, Kinloch-Loes S, Orkin C, Collins S, Zacharopoulou P, Robison N, Bittar C, Oliveira T, Gazumyan A, Jankovic M, Seaman MS, Frater J, Caskey M, Fidler S, Nussenzweig MC
Author Correction: A single residue in the yellow fever virus envelope protein modulates virion architecture and antigenicity.
1. Nat Commun - published November 5, 2025
2. Bibby S, Jung J, Low YS, Amarilla AA, Newton ND, Scott CAP, Balk J, Ting YT, Freney ME, Liang B, Grant T, Coulibaly F, Young P, Hall RA, Hobson-Peters J, Modhiran N, Watterson D
Modular protein scaffold architecture and AI-guided sequence optimization facilitate de novo metalloenzyme engineering.
1. Structure - published November 5, 2025
2. Wagner Egea P, Delhommel F, Mustafa G, Leiss-Maier F, Klimper L, Badmann T, Heider A, Wille I, Groll M, Sattler M, Zeymer C
Structural basis of isethionate transport by a TRAP transporter from a sulfate-reducing bacterium.
1. Structure - published November 5, 2025
2. Newton-Vesty MC, Scalise M, Jamieson SA, Currie MJ, Brown HG, Valimehr S, Tillett ZD, Hall KR, Quan S, Allison JR, Whitten AE, Panjikar S, Indiveri C, Hanssen E, Mace PD, North RA, Dobson RCJ, Davies JS
Synaptobrevin-2 disease variants reveal spatial constraints within the presynaptic active zone.
1. Proc Natl Acad Sci U S A - published November 4, 2025
2. Guzikowski NJ, Bagatelas ED, Shin OH, Khan YA, Esquivies L, Alten B, Brunger AT, Kavalali ET
LRP8 is an entry receptor for tick-borne encephalitis viruses.
1. Proc Natl Acad Sci U S A - published November 4, 2025
2. Li P, Hui S, Chong Z, Escaffre O, Nguyen MN, Muraro SP, Janova H, Ma H, Cao S, Kaszuba T, Imbiakha B, Palakurty S, Pearson ML, Price DA, Amarasinghe GK, Leung DW, Rossi SL, Freiberg AN, Fremont DH, Diamond MS
Corrigendum to "Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2". [J. Mol. Biol. 433 (2021) 166980].
1. J Mol Biol - published November 4, 2025
2. Kowal J, Ni D, Jackson SM, Manolaridis I, Stahlberg H, Locher KP
Generation of antigen-specific paired-chain antibodies using large language models.
1. Cell - published November 4, 2025
2. Wasdin PT, Johnson NV, Janke AK, Held S, Marinov TM, Jordaan G, Gillespie RA, Vandenabeele L, Pantouli F, Powers OC, Vukovich MJ, Holt CM, Kim J, Hansman G, Logue J, Chu HY, Andrews SF, Kanekiyo M, Sautto GA, Ross TM, Sheward DJ, McLellan JS, Abu-Shmais AA, Georgiev IS
The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice.
1. PLoS Pathog - published November 3, 2025
2. Peritore-Galve FC, Kroh HK, Shupe JA, Ehni AG, Cano Rodríguez R, Kordus SL, Washington MK, Knippel RJ, Stanley AM, Gamson A, Tkaczyk C, Lacy DB
The path to equitable respiratory syncytial virus prevention for infants: challenges and opportunities for global implementation.
1. Lancet Glob Health - published November 3, 2025
2. Shaaban FL, Groenendijk RW, Baral R, Caballero MT, Crowe JE Jr, Englund JA, Esteban I, Hirve S, Jit M, Kalergis AM, Karron RA, Lukacs N, Martinon-Torres F, Mejias A, Nair H, Nisar MI, Nyiro JU, Pecenka C, Sparrow E, Srikantiah P, Thwaites RS, Zar HJ, Bont LJ
Broad anti-sarbecovirus responses elicited by a single administration of mosaic-8 RBD-nanoparticle vaccine prepared using atomic layer deposition.
1. iScience - published November 2, 2025
2. Cohen AA, Keeffe JR, Rorick AV, Rho S, Priso Fils AC, Manasyan L, Gao H, Gnanapragasam PNP, Funke HH, Randolph TW, Garcea RL, Bjorkman PJ
Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity.
1. Mol Cell - published November 2, 2025
2. Yu C, Wang C, Forman T, Xie J, Major S, Fang MX, Voyer JE, Pogliano J, Fu TM
DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors.
1. iScience - published November 2, 2025
2. Gray JP, Bildik G, Kim HN, Sutton MN, Wang J, Osuji AO, Batistatou N, Yang H, Mao W, Tan Z, Gasmi-Seabrook GMC, Liu J, Hancock JF, Marshall CB, Kritzer JA, Ikura M, Bast RC Jr, Millward SW, Lu Z
Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery.
1. Proc Natl Acad Sci U S A - published November 2, 2025
2. Haudiquet M, Chakravarti A, Zhang Z, Ramirez JL, Herrero Del Valle A, Olinares PDB, Lavenir R, Ahmed MA, de la Cruz MJ, Chait BT, Sternberg SH, Bernheim A, Patel DJ
A periplasmic zinc capture protein enhances the resistance of Neisseria gonorrhoeae to nutritional immunity.
1. Proc Natl Acad Sci U S A - published November 2, 2025
2. Liyayi IK, Bera AK, Perera YR, Ferdausi N, Bhatia I, Noinaj N, Chazin WJ, Cornelissen CN, Criss AK
The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance.
1. Nat Rev Mol Cell Biol - published November 2, 2025
2. Chin Sang C, Upadhyay S, Nosella ML, Forman-Kay JD, Lee HO
Multi-proteomics reveals integrated metabolic and regulatory networks for xylan catabolism in Streptomyces sp. SirexAA-E.
1. Microbiol Spectr - published November 2, 2025
2. Nagano T, Ohashi K, Banko P, Kumar V, Hori C, Fox BG, Takasuka TE
Hepatocyte mitochondrial NAD(+) content is limiting for liver regeneration.
1. Nat Metab - published November 2, 2025
2. Mukherjee S, Velázquez Aponte RA, Perry CE, Lee WD, Janssen KA, Niere M, Adzika GK, Lu MJ, Chan HR, Zou X, Chen B, Bye N, Xiao T, Yook JS, Salik O, Frederick DW, Gaspar RB, Doan KV, Davis JG, Rabinowitz JD, Wallace DC, Snyder NW, Kajimura S, Cambronne XA, Ziegler M, Baur JA
Advances in biomarker discovery for peripartum cardiomyopathy: current status and future directions.
1. Expert Rev Cardiovasc Ther - published November 2, 2025
2. Pretorius E, Sai SRAV, Barnet A, Kodogo V, Sliwa K, Chakafana G, Zininga T
ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes.
1. Nat Commun - published November 2, 2025
2. Dai B, Sperl AW, Polack L, Mejia I, Dame H, Huynh T, Deveney C, Lavoie N, Lee C, Doench JG, Daugherty MD, Heldwein EE
Targeting ACE2 with a camelid antibody inhibits SARS-CoV-2 binding and has protective effects in vivo.
1. Nat Commun - published November 2, 2025
2. Blachier S, Vaney MC, Conquet L, Staropoli I, Fernández I, Giraud E, Arbabian A, Michel V, Szilagyi F, Guez S, Boucharlat A, Chiaravalli J, Tran-Rajau J, Dufour E, Haouz A, Petres S, Planas D, Montagutelli X, Agou F, Lafaye P, Ayme G, Schwartz O, Rey FA, Enninga J, Brelot A
IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy.
1. Immunity - published November 2, 2025
2. Jiang H, Limsuwannarot S, Kulhanek KR, Pal A, Labiad O, Rysavy LW, Wong A, Su L, Cavender S, Soro J, Testa S, Ogana H, Waghray D, Tao P, Jude KM, Seet CS, Crooks GM, Moding EJ, Garcia KC, Kalbasi A
Drug-bound outward-facing conformation of a heterodimeric ABC exporter suggests a putative mechanism of drug translocation.
1. Nat Commun - published November 2, 2025
2. Tang Q, Sinclair M, Bisignano P, Zhang Y, Tajkhorshid E, Mchaourab HS
Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan-Coronavirus Vaccine Development.
1. Adv Sci (Weinh) - published November 2, 2025
2. Huang S, Cohen KM, Chen L, Kang X, Liu C, Demouth ME, Jiang W, Maldeney AR, Tong R, Ke Z, Chandran K, Luo W, Yin Q
Outcomes Following Matched Sibling Donor Transplantation for Severe Combined Immunodeficiency: A Report from the PIDTC.
1. Blood Adv - published November 2, 2025
2. Rayes A, Logan BR, Liu X, Dara J, Buckley RH, Oved JH, Kapoor N, Kapadia M, Chandra S, Martinez CA, Bunin N, Chandrakasan S, Chen K, Bednarski JJ, Haines HL, Eissa H, Talano JM, Keller MD, Ebens CL, Chaudhury S, Shereck EB, Aquino VM, Knutsen AP, Alexander JL, Gillio AP, Chellapandian D, Shah AJ, Miller HK, Vander Lugt MT, Seroogy CM, Dorsey MJ, Mousallem T, Parrott RE, O'Reilly RJ, Aguayo-Hiraldo PI, Prockop SE, Dávila Saldaña BJ, Thakar MS, Burroughs LM, Torgerson TR, Leiding JW, Marsh RA, Griffith LM, Pulsipher MA, Kohn DB, Notarangelo LD, Cowan MJ, Puck JM, Cuvelier GDE, Heimall J, Haddad E, Pai SY, Dvorak CC
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs.
1. Mol Cell - published November 2, 2025
2. Glauninger H, Bard JAM, Wong Hickernell CJ, Velez KM, Airoldi EM, Li W, Singer RH, Paul S, Fei J, Sosnick TR, Wallace EWJ, Drummond DA
WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response.
1. Nat Commun - published November 2, 2025
2. Tjeerdsma RB, Ng TF, Roorda M, Bianchi D, Yang S, Bonnet C, VanInsberghe M, Everts M, Bakker FJ, de Boer HR, Moatti N, Hustedt N, Yin JZ, Hoeg L, Leibovitch M, Sicheri F, van Oudenaarden A, de Jong S, van den Berg J, Tanenbaum ME, Brummelkamp TR, Durocher D, van Vugt MATM
Pharmacogenomics and chronotherapy of drug-induced cardioprotection in acute myocardial infarction.
1. Nat Commun - published November 2, 2025
2. Clemente-Moragón A, Suárez-Barrientos A, Gómez Tech M, López-Palomar Tech LP, Callejas Alejano S, Martínez F, Fernández FJ, Vega MC, Tech AP, Dopazo A, Sánchez-Cabo F, Fuster V, Oliver E, Ibáñez B
Controlling Megasynthetase Module-Module Interactions through β-Hairpin Docking Domain Engineering.
1. ACS Chem Biol - published November 2, 2025
2. Rankin MR, Contreras KL, Gerwick WH, Gerwick L, Smith JL
A PIP2-stabilized syntaxin-1a structure mapped with transition metal ion FRET and unnatural fluorescent amino acids at the plasma membrane.
1. Structure - published November 2, 2025
2. Obashi K, Strub MP, Taraska JW
Latent-TGF-β has a domain swapped architecture.
1. Nat Commun - published November 2, 2025
2. Jin M, Seed RI, Shing T, Wang L, Li J, Cheng Y, Nishimura SL
Opsins are phospholipid scramblases in all domains of life.
1. mBio - published November 2, 2025
2. Maschmann ZA, Hardy DE, Menon I, Webb J, Menon AK, Forest KT
Development of FBXO22 Degraders and the Recruitment Ligand 2-Pyridinecarboxyaldehyde (2-PCA).
1. J Am Chem Soc - published November 2, 2025
2. Qiu T, Zhuang Z, Byun WS, Kozicka Z, Baek K, Zhong J, Thornhill AM, Ryan JK, Donovan KA, Fischer ES, Ebert BL, Gray NS
Spatial constraints drive amylosome-mediated resistant starch degradation by Ruminococcus bromii in the human colon.
1. Nat Commun - published November 2, 2025
2. Wimmer BH, Moraïs S, Amit I, Tovar-Herrera O, Tatli M, Trautwein-Schult A, Pfister B, Zalk R, Tödtli P, Simoni S, Lisibach M, Levin L, Becher D, Bayer EA, Medalia O, Mizrahi I
Hierarchical folding-upon-binding of an intrinsically disordered protein.
1. Nat Commun - published November 2, 2025
2. Kjaer LF, Ielasi FS, Winbolt T, Delaforge E, Tengo M, Bessa LM, Mariño Pérez L, Boeri Erba E, Bouvignies G, Palencia A, Jensen MR
Effect of the S2' site cleavage on SARS-CoV-2 spike.
1. Nat Commun - published November 2, 2025
2. Shi W, Jonaid GM, Kibria MG, Allen J, Peng H, Rits-Volloch S, Zhu H, Wang S, Walsh RM, Lu J, Chen B
Functional and clinical significance of the RNA m(6)A methyltransferase complex in breast cancer.
1. NPJ Breast Cancer - published November 2, 2025
2. Harris AE, Lothion-Roy J, Thompson RL, Haque M, Woodcock CL, Alsaleem MA, Dean A, Kariri Y, Toss MS, Gudas LJ, Green AR, Allegrucci C, Davis MB, Irshad S, Park KH, Madhusudan S, Fray RG, Jeyapalan JN, Rutland CS, Rakha EA, Mongan NP
Mutations in the β-tubulin TUBB impair ciliogenesis and are associated with ciliopathy-like phenotypes.
1. Nat Commun - published November 2, 2025
2. Mollica A, Omer S, Forguson G, Steiman S, Evagelou SL, Naumenko S, Walker S, Li LY, Teeling A, Lindsay K, Erwood S, Visuvanathan S, Vig A, Vernon RM, Akman B, Smith-Hicks C, Forman-Kay JD, Shroff M, Pai V, Harrison RE, Cohn RD, Ivakine EA
AlphaFold-guided phylogenetic analyses suggest surprising heterogeneity in metazoan replication origin licensing mechanisms.
1. EMBO J - published November 2, 2025
2. Hunker O, Bleichert F
Convergent evolution of viral-like Borg archaeal extrachromosomal elements and giant eukaryotic viruses.
1. Nat Commun - published November 2, 2025
2. Banfield JF, Valentin-Alvarado LE, Shi LD, Robinson CM, Bamert RS, Coulibaly F, Barth ZK, Aylward FO, Schoelmerich MC, Lei S, Sachdeva R, Knott GJ
An ELISA for discovering protein-protein interaction inhibitors: blocking lysinoalanine crosslinking between subunits of the spirochete flagellar hook as a test case.
1. SLAS Discov - published November 2, 2025
2. Deshpande M, Lynch MJ, Kurniyati K, Li C, Crane BR
FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites.
1. Cell Rep - published November 2, 2025
2. Leng F, Clark R, Zhang W, Viennet T, Wang C, Arthanari H, Wang X, Hur S
Molecular Insights into the Engagement of High-Affinity Sialylated Ligands to Human CD22.
1. JACS Au - published November 2, 2025
2. Ereño-Orbea J, Pang L, Sicard T, Nycholat C, Cui H, Borovsky D, Franconetti A, Jiménez-Barbero J, Paulson JC, Julien JP
Ancestral Chaperonins Provide the First Structural Glimpse into Early Multimeric Protein Evolution.
1. Mol Biol Evol - published November 2, 2025
2. Severino R, Cuéllar J, Gutiérrez-Seijo J, Maestro-López M, Sánchez-Pulido L, Santiago C, Moreno-Paz M, Valpuesta JM, Parro V
Phase Ib study of enzalutamide with venetoclax in patients with metastatic castration-resistant prostate cancer.
1. Cancer Chemother Pharmacol - published November 2, 2025
2. Perimbeti S, Jamroze A, Gopalakrishnan D, Jain R, Jiang C, Holleran JL, Parise RA, Bies R, Quinn D, Attwood K, Liu X, Green K, Kirk JS, Beumer JH, Tang DG, Chatta G
LRP1 facilitates Jamestown Canyon virus infection of neurons.
1. J Virol - published November 2, 2025
2. Frey ZD, Price DA, Connors KA, Rush RE, Brown G, Sterling CE, Fatma F, Ganaie SS, Cui X, Wills ZP, Amarasinghe GK, Leung DW, Hartman AL
Distinct quaternary states, intermediates, and autoinhibition during loading of the DnaB-replicative helicase by the phage λP helicase loader.
1. Nucleic Acids Res - published November 2, 2025
2. Shatarupa A, Brown D, Olinares PDB, Chase J, Isiorho E, Chait BT, Jeruzalmi D
How ATP and dATP reposition class III ribonucleotide reductase cone domains to regulate enzyme activity.
1. Sci Adv - published November 2, 2025
2. Andree GA, Miller-Brown KR, Zhao Z, Smith AK, Dawson CD, Deredge DJ, Drennan CL
Cone snail venom-inspired somatostatin receptor 4 (SSTR(4)) agonists as new drug leads for peripheral pain.
1. Sci Rep - published November 2, 2025
2. Bjørn-Yoshimoto WE, Ramiro IBL, Koch TL, Engholm E, Yeung HY, Sørensen KK, Goddard CM, Jensen KL, Smith NA, Martin LF, Smith BJ, Madsen KL, Jensen KJ, Patwardhan A, Safavi-Hemami H
ExoSloNano: multimodal nanogold labels for identification of macromolecules in live cells and cryo-electron tomograms.
1. Nat Methods - published November 2, 2025
2. Young LN, Sherrard A, Zhou H, Shaikh F, Hutchings J, Riggi M, Narasimhan M, Flaherty WA, Bennett EJ, Rosen MK, Giraldez AJ, Villa E
Self-assembled cell-scale containers made from DNA origami membranes.
1. Nat Mater - published November 2, 2025
2. Karfusehr C, Eder M, Yang HY, Beinsteiner B, Jasnin M, Simmel FC
Structure of an LGR dimer, an evolutionary predecessor of glycoprotein hormone receptors.
1. Nat Commun - published November 2, 2025
2. Gong Z, Chen S, Fu Z, Kloss B, Wang C, Kim J, Clarke OB, Fan QR, Hendrickson WA
Mechanistic insights into histone recognition and H3K14 acetylation by the NuA3 histone acetyltransferase complex.
1. Nat Commun - published November 2, 2025
2. Shi W, Zhao L, Wang Y, Zhang Y, Liu S, Wang Y, Kornberg RD, Zhang H
Unraveling the prevalence and multifaceted roles of accessory peptide deformylases in bacterial adaptation and resistance.
1. Mol Biol Evol - published November 2, 2025
2. Lambérioux M, Ducos-Galand M, Kaminski PA, Littner E, Betton JM, Mechaly A, Haouz A, Mazel D
Development of ACE2-tropic-betacoronavirus therapeutics for future pandemic preparedness.
1. Nat Commun - published November 2, 2025
2. Utz A, Armbrust M, Nguyen TT, Morris MK, Matthews CO, Kompella P, Cao Z, Ha JW, Violette A, Brewer RC, Lanz TV, Robinson WH, Xu D, Hanson C, Hugenmatter A, Kim PS
Structural basis for MEKK2 dimerization and substrate recognition.
1. Nat Commun - published November 2, 2025
2. Vish KJ, Huet-Calderwood C, Ha BH, Calderwood DA, Boggon TJ
Rapid DNA Cleavage by the LINE-1 Endonuclease Proximal to DNA Ends and at Mismatches.
1. J Biol Chem - published November 2, 2025
2. Miller BD, Smail BA, Van Eeuwen T, Kodama H, Kondo K, Jiang H, O'Brien A, Dai N, Trachman RJ 3rd, Guan S, Karlow JA, Cheng WC, Sedivy JM, Jogl G, Rout MP, LaCava J, Burns KH, Taylor MS
Hybrid Antibiotics Targeting the Bacterial Ribosome.
1. ACS Cent Sci - published November 2, 2025
2. Yeon SK, Pellegrino J, Raskar T, Tran MLN, Dandan M, Guérin F, Einsiedler M, Cattoir V, Fraser JS, Seiple IB
PARP1 and PARylation facilitate transcription-coupled DNA repair by stabilizing the CSB-RNAPII complex.
1. Nucleic Acids Res - published November 2, 2025
2. Robu M, Shah RG, van den Heuvel D, Coulombe Y, Bazin M, van der Woude M, Kragten A, Lans H, Pascal JM, Masson JY, Luijsterburg MS, Shah GM
Design and synthesis of novel 4-aryl-2-benzoyl-imidazoles as colchicine binding site inhibitors.
1. Eur J Med Chem - published November 1, 2025
2. Albadari N, Xie Y, Wang Q, Miller DJ, Gruntz JQ, Oldham ML, Chen H, Ma D, Wu Z, Miller DD, Li W
Magellon - an extensible platform for cryo-EM data visualization, management and processing.
1. IUCrJ - published November 1, 2025
2. Khoshbin B, Damodar P, Garje RR, Schotanus FH, Nair N, Wei L, Schäfer JH, Lander GC, Cianfrocco MA, Stagg SM
Characterization of microplastics and associated metals in green mussel cultivation: Estimation of potential health risks.
1. Chemosphere - published November 1, 2025
2. Irnidayanti Y, Purwanto MD, Soegianto A, Hartl MGJ, Sarma H, Narayan M
Directed evolution of a beta-lactamase samples a wide variety of conformational states.
1. Protein Sci - published November 1, 2025
2. Sun J, Timmer M, Brünle S, Boyle AL, Ubbink M
High-affinity omalizumab variants with optimized disruptive potency prevent anaphylaxis in vivo.
1. J Allergy Clin Immunol - published November 1, 2025
2. Brigger D, Guntern P, Pennington LF, van Brummelen R, Jardetzky TS, Eggel A
Monkeypox Virus Is Inhibited by Nucleoside Analogues Including the Acyclic Phosphonates Adefovir and Tenofovir In Vitro.
1. J Med Virol - published November 1, 2025
2. Lee J, Zhang H, Boggs EA, Kilcullen J, Moriarty M, Du Y, Fu H, Lan S, Hutson CL, Satheshkumar PS, Tedbury PR, Sarafianos SG
Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B.
1. Nat Microbiol - published November 1, 2025
2. Roark RS, Schaub AJ, Shi W, Wang M, Bahna FA, Becker JE, Biju A, Chong S, Du H, Guo Y, Hong H, Katsamba PS, Mannepalli SM, Olia AS, Ou L, Rubin SK, Sabo Y, Suleiman M, Wells ML, Zhang B, Cheng C, Glasgow A, Ho DD, Huang Y, Pierson TC, Rawi R, Zhou T, Shapiro L, Kwong PD
Sticking around: σ factor dynamics and implications for transcription elongation.
1. Proc Natl Acad Sci U S A - published November 1, 2025
2. Mooney RA, Landick R
Conformational regulation of two essential activators of bacterial cell elongation.
1. Proc Natl Acad Sci U S A - published November 1, 2025
2. Gilman MSA, Shlosman I, Guerra DDS, Domecillo M, Fivenson EM, Bourett C, Bernhardt TG, Polizzi NF, Loparo JJ, Kruse AC
Essential and dispensable domains of DivIVA for walled growth in filamentous Actinomycetota.
1. Open Biol - published November 1, 2025
2. Lubbers M, Bajramović B, Ongenae V, Willemse J, de Bruin D, Mulder N, Zhang L, Vriesendorp B, Barona-Gomez F, Briegel A, van Wezel GP, Flärdh K, Claessen D
A Structural Perspective on Insect Gustatory Receptors.
1. Chem Senses - published November 1, 2025
2. Gomes JV, Reilly RA, Butterwick JA
Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity.
1. J Virol - published November 1, 2025
2. Jamieson PJ, Shen X, Abu-Shmais AA, Wasdin PT, Janowska K, Edwards RJ, Scapellato G, Bukenya M, Bass LE, Richardson SI, Manamela NP, Liu S, Barr M, Adams L, Paola Velez-Castro C, McCarthy C, Alexander CA, Gillespie RA, Mimms J, Suryadevara N, Sornberger TA, Zost SJ, Parks R, Flaherty S, Janke AK, Howard BN, Suresh YP, Ruprecht RM, Crowe JE Jr, Carnhan RH, Bailey JR, Kanekiyo M, Lingwood D, Haynes BF, Moore PL, Bonami RH, Tomaras GD, Archarya P, Montefiori DC, Kalams SA, Lu S, Georgiev IS
Publisher Correction: Radiation-induced amphiregulin drives tumour metastasis.
1. Nature - published November 1, 2025
2. Piffkó A, Yang K, Panda A, Heide J, Tesak K, Wen C, Zawieracz K, Wang L, Naccasha EZ, Bugno J, Fu Y, Chen D, Donle L, Lengyel E, Tilley DG, Mack M, Rock RS, Chmura SJ, Vokes EE, He C, Pitroda SP, Liang HL, Weichselbaum RR
Alterations in Cardiovascular Parameters in 5xFAD Murine Model.
1. Cell Biochem Funct - published November 1, 2025
2. Marshall AG, Stephens D, Neikirk K, Masenga SK, Shao B, Crabtree A, Vue Z, Beasley HK, Garza-Lopez E, Scudese E, Rodriguez BI, Le H, Damo S, Taffet GE, Ochayi OM, McMillan R, Afolabi JM, Exil V, Oliver A, Sharma V, Martin P, Gaye A, Harris C, Tomeau B, Bell L, Hamilton M, Gillyard T, Webster R, Jackson M, Prakash P, Frierson S, Dash C, Mungai M, Kirabo A, Gaddy JA, Wandira N, Hinton A Jr, Reddy AK
Zero-shot segmentation using embeddings from a protein language model identifies functional regions in the human proteome.
1. PLoS Comput Biol - published November 1, 2025
2. Sangster AG, Dufault C, Qu H, Le D, Forman-Kay JD, Moses AM
MicroRNA-142 improves IL1RAP CAR-T cell activity in acute myeloid leukemia.
1. J Hematol Oncol - published November 1, 2025
2. Harada K, Zhao D, Park M, Chen F, Xu Y, Zhang Y, Zhou Y, Parcutela B, Jewel Y, Munoz A, Amanam I, Nguyen LXT, Chen J, Ghoda L, Forman SJ, Williams JC, Zhang B, Marcucci G
Breaking Barriers: Respiratory Viral Strategies Targeting the Host's Nuclear Pore Complex and Nuclear Transport Pathways.
1. Mol Biol Cell - published November 1, 2025
2. Udi Y, Aitchison JD, Rout MP, Obado S
Cryo-EM structure of bacteriophage Bas63 reveals structural conservation and diversity in the Felixounavirus genus.
1. Sci Adv - published November 1, 2025
2. Hodgkinson-Bean J, Ayala R, McJarrow-Keller K, Cassin L, Rutter GL, Crowe AJM, Wolf M, Bostina M
A composite motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin.
1. Nat Commun - published November 1, 2025
2. Bradburn DA, Reis JC, Moreno RY, Qayyum S, Viennet T, Arthanari H, Cyert MS
ONECUT2: A Validated Drug Target and Lineage Plasticity Driver in Prostate Cancer and Other Malignancies.
1. Endocr Relat Cancer - published November 1, 2025
2. Freeman MR, Perez LM, Yang Q, Qian C, Murali R, Rotinen M, Posadas EM, Di Vizio D, Freedland SJ, You S
William J. Rutter 1927-2025.
1. Nat Biotechnol - published November 1, 2025
2. Craik CS
Physical and functional interaction of Lrrc56 and Odad3 is required for deployment of axonemal dyneins in vertebrate multiciliated cells.
1. Dis Model Mech - published November 1, 2025
2. Reyes-Nava NG, Lee C, Papoulas O, Hong J, Marcotte EM, Wallingford JB
Structural Insights into De Novo Promoter Escape by Mycobacterium tuberculosis RNA Polymerase.
1. Nat Commun - published November 1, 2025
2. Brewer J, Delbeau M, Zoullas WB, Darst SA, Campbell EA
ALLOSTERIC REGULATION OF PROSTAGLANDIN ENDOPEROXIDE H(2) SYNTHASES.
1. J Biol Chem - published November 1, 2025
2. Dong L, Malkowski MG
Spermatozoa lacking TEX51 display hypofertility and defects in morphology.
1. Commun Biol - published November 1, 2025
2. Dupuis S, Le Beulze M, Vance TDR, Pierre R, Lee JE, Ziyyat A, Barbaux S
PCNA is a nucleotide exchange factor for the clamp loader ATPase complex.
1. Proc Natl Acad Sci U S A - published November 1, 2025
2. Pajak J, Landeck JT, Liu X, Anand K, Litvak S, Kelch BA
Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction with inhibitory receptors.
1. Signal Transduct Target Ther - published November 1, 2025
2. Zhang C, He Y, Liu X, Xie J, Fang M, Yang X, Huang R, Lou Q, Li B, Gupta A, Lewis C, Diamond MI, Zhang N, An Z, Zhang CC
Novel Wide-Spectrum Virucidal Lipid Nanoparticles.
1. Small - published November 1, 2025
2. Martins YA, Bondeelle L, Zwygart AC, de Lima TM, Souza JP, Tee HK, Chahud F, Neto EA, Stellacci F, Lopez RFV, Tapparel C
CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model.
1. Sci Immunol - published November 1, 2025
2. Zhu DY, Maurer DP, Castrillon C, Deng Y, Mohamed FAN, Ma M, Tang D, Min-Debartolo J, Higginson-Scott N, Buhlmann J, Schmidt AG, Lingwood D, Carroll MC
Pharmacological suppression of lactate mitigates postoperative cognitive dysfunction.
1. Exp Neurol - published November 1, 2025
2. Wang W, Song W, Gong P, Bu X, Zhang L, Zhao B
Degrons and degradation signals beyond short linear motifs.
1. Nat Chem Biol - published November 1, 2025
2. Wang B, Zheng N
Dynamics driving the precursor in NifEN scaffold during nitrogenase FeMo-cofactor assembly.
1. Nat Chem Biol - published November 1, 2025
2. Payá Tormo L, Nguyen TQ, Fyfe C, Basbous H, Dobrzyńska K, Echavarri-Erasun C, Martin L, Caserta G, Legrand P, Thorn A, Amara P, Schoehn G, Cherrier MV, Rubio LM, Nicolet Y
Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.
1. Bioorg Med Chem Lett - published November 1, 2025
2. Mamai A, Morshed MM, Prakesch M, Poda G, Subramanian P, Chau AM, Watson IDG, Joseph B, Wilson B, Morin JA, Marcellus R, Theriault B, Mohammed M, Abibi A, Chan M, Kiyota T, Aman A, Subramaniam R, Strathdee C, Winston J, O'Meara J, Kuntz D, Pomroy N, Uehling D, Isaac M, Privé GG, Al-Awar R
Oral delivery of Silybin via HA-DOCA-functionalized zein nanocolloids for amelioration of liver fibrosis.
1. Int J Biol Macromol - published November 1, 2025
2. Wen L, Wu J, Zhao Y, Sun Z, Liang C, Liu X, Luo J, Li X
Cryo-EM structure of Archaeoglobus fulgidus type III-B CRISPR-Cas effector and intermediate crRNA processing during effector assembly.
1. Biochem Biophys Res Commun - published November 1, 2025
2. Ishihara K, Kitagawa S, Adachi N, Akutsu M, Senda T, Inanaga H, Numata T
Structures of human organellar SPFH protein complexes.
1. Nat Commun - published November 1, 2025
2. Gao J, Sherpa D, Kupko N, Chino H, Zeng J, Shao S
Author Correction: Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
1. Nat Cell Biol - published November 1, 2025
2. De Jesus DF, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis.
1. Nat Ecol Evol - published November 1, 2025
2. Tikanova P, Ross JJ, Hagmüller A, Pühringer F, Pliota P, Krogull D, Stefania V, Hunold M, Koreshova A, Koller A, Ostapchuk I, Okweri J, Gokcezade J, Duchek P, Dong G, Ben-David E, Burga A
Filament formation and NAD processing by noncanonical human FAM118 sirtuins.
1. Nat Struct Mol Biol - published November 1, 2025
2. Baretić D, Missoury S, Patel K, Martinez M, Coste F, Zhu K, Smith R, Kopasz AG, Lu Y, Bigot N, Chapuis C, Riou R, Đukić N, Goffinont S, Pressoir V, Patačko S, Timinszky G, Delarue M, Castaing B, Ahel D, Mikoč A, Huet S, Ahel I, Suskiewicz MJ
[Rehospitalizations after tracheostomy tube insertion in pediatrics: a quantitative retrospective cross-sectional study].
1. Pflege - published November 1, 2025
2. Caflisch A, Waldboth V, Seliner B
Frame-Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design.
1. Angew Chem Int Ed Engl - published November 1, 2025
2. Bastick KAC, Griesbach CE, Huang BZ, Cordell MJ, Ou YD, Aspuru-Guzik A, Yudin AK
CpoS-Inc interactions facilitate host cell modulation during Chlamydia trachomatis infection.
1. Infect Immun - published November 1, 2025
2. Tijerina X, Jabeena C, Faris R, Xu Z, Smith P, Schnicker NJ, Weber MM
Enrichment-Free, Targeted Covalent Drug Discovery in Live Cells.
1. ACS Chem Biol - published November 1, 2025
2. Dong KD, Yu Q, Yang K, Wong BJ, Yue H, Fu S, Whitehouse RL, Fischer ES, Gygi SP
Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap.
1. Nat Chem Biol - published November 1, 2025
2. Lin Z, Ngo W, Chou YT, Wu H, Susa KJ, Jun YW, Bivona TG, Doudna JA, Wells JA
Structural Biology Enabling Drug Discovery.
1. J Med Chem - published November 1, 2025
2. Heppner DE, Bigi-Botterill SV, Riley AP, Chibale K, Lindsley CW
Structural basis of regulated N-glycosylation at the secretory translocon.
1. Nature - published November 1, 2025
2. Yamsek M, Ma M, Jha R, Wan Y, Li Q, Zhong F, DeLong K, Ji Z, Rohatgi R, Keenan RJ
Doxorubicin recognition and transport by the MATE multidrug transporter NorM from Vibrio cholerae.
1. J Mol Biol - published November 1, 2025
2. Hsieh PY, Romane K, Kowal J, Locher KP, van Veen HW
Repulsions instruct synaptic partner matching in an olfactory circuit.
1. Nature - published November 1, 2025
2. Li Z, Lyu C, Xu C, Hu Y, Luginbuhl DJ, Caspi-Lebovic AB, Priest JM, Özkan E, Luo L
CD40 Drives Tumor Growth in Non-Small Cell Lung Cancer via non-canonical Immune-Independent Mechanisms.
1. Cancer Lett - published November 1, 2025
2. Liu Y, Prasad CB, Qiu Z, Singh D, Bean N, Honne S, Zhang X, Yan C, Li Z, Kim B, Wang QE, Zhang J
The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2.
1. Elife - published November 1, 2025
2. Suryawanshi RK, Jaishankar P, Correy GJ, Rachman MM, O'Leary PC, Taha TY, Matsui Y, Zapatero-Belinchón FJ, McCavitt-Malvido M, Doruk YU, Stevens MGV, Diolaiti ME, Jogalekar MP, Chen H, Richards AL, Kongpracha P, Bali S, Montano M, Rosecrans J, Matthay M, Togo T, Gonciarz RL, Gopalkrishnan S, Neitz RJ, Krogan NJ, Swaney DL, Shoichet BK, Ott M, Renslo AR, Ashworth A, Fraser JS
Structure of the transcriptional co-activator SAGA complex, including the histone acetyltransferase module.
1. Mol Cell - published November 1, 2025
2. Mattoo RUH, Chen DH, Bushnell DA, Tamir S, Kornberg RD
Structural basis of DNA-dependent coactivator recruitment by the tuft cell master regulator POU2F3.
1. Cell Rep - published November 1, 2025
2. Alpsoy A, Ipsaro JJ, Skopelitis D, Pal S, Chung FS, Carpenter S, Desmarais JJ, Wu XS, Chang K, DiMare MT, Harten E, Bergman S, Kinney JB, Engelman JA, Bhang HC, Joshua-Tor L, Vakoc CR
The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation.
1. bioRxiv - published November 1, 2025
2. Li H, Guan H, Rapoport TA
Structural Analysis of Inhibitor Binding to the Feline Enteric Coronavirus (FECV) Main Protease.
1. Viruses - published November 1, 2025
2. Maryam A, Moquin SA, Dovala D, Kaur J, Kurt Yilmaz N, Shaqra AM, Schiffer CA