Member Publications

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152 Member Publications for July 2025

Editorial: Molecular chaperones and polyamines in disease.
1. Front Mol Biosci - published July 24, 2025
2. Makumire S, Chakafana G, Makhoba XH
Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin.
1. Science - published July 24, 2025
2. Terayama K, Furuzono S, Fer N, Yan W, Young LC, Czyzyk DJ, Goldstein de Salazar R, Sasaki M, Uozumi A, Konishi M, Kanda S, Sogawa Y, Yamaguchi M, Tsuji T, Kuroyanagi J, Hayashi M, Ogura Y, Simanshu DK, Kubota K, Tanaka J, McCormick F
Integrating MaxEnt with chemometrics to evaluate the impact of environmental variables on the coumarin content and the distribution of Angelica dahurica.
1. Front Plant Sci - published July 23, 2025
2. Gan Z, Ma J, Liu X, Luo J, Li J, Pu L, Jiang G, Lian Y
Secreted retropepsin-like enzymes are essential for stress tolerance and biofilm formation in Pseudomonas aeruginosa.
1. mBio - published July 9, 2025
2. Lormand JD, Savelle CH, Teschler JK, López E, Little RH, Malone JG, Yildiz FH, García-García MJ, Sondermann H
Activating and inhibiting nucleotide signals coordinate bacterial anti-phage defense.
1. bioRxiv - published July 9, 2025
2. Yamaguchi S, Fernandez SG, Wassarman DR, Lüders M, Schwede F, Kranzusch PJ
Developing a Maternal Health Education and Research Training Program for High School, Pharmacy, and Health Sciences Students.
1. Int J Environ Res Public Health - published July 9, 2025
2. Olorunyomi G, Torres C, Norwood K, Taylor L, Jones J, Pounds K, Idowu K, Guinn D, King D, Ajewole-Mwema V, Poon I, Olaleye E
SpbR controls lipoteichoic acid length by directly inhibiting signal peptidase SpsB in Staphylococcus aureus.
1. Proc Natl Acad Sci U S A - published July 8, 2025
2. Park Y, Sisley TA, Stone MC, Corrigan RM, Vickery CR, Gründling A, Walker S
Distant ribose 2'-O-methylation of 23S rRNA helix 69 pre-orders the capreomycin drug binding pocket at the ribosome subunit interface.
1. Nucleic Acids Res - published July 8, 2025
2. Nandi S, Dey D, Srinivas P, Dunham CM, Conn GL
The Functional Topology of Phenylpiperazinium Agonists and Antagonists on the Nicotinic Acetylcholine Receptor Landscape: Pointing the Way for Future Therapeutic Management of Inflammation and Neuropathic Pain.
1. ACS Chem Neurosci - published July 8, 2025
2. Andleeb H, Gulsevin A, Papke RL
A practical look at cryo-electron tomography image processing: Key considerations for new biological discoveries.
1. Curr Opin Struct Biol - published July 8, 2025
2. Wan W
The XNA alphabet.
1. Nucleic Acids Res - published July 8, 2025
2. Chaput JC, Egli M, Herdewijn P
Cargo adaptors use a handhold mechanism to engage with myosin V for organelle transport.
1. J Cell Biol - published July 7, 2025
2. Hahn HJ, Pashkova N, Cianfrocco MA, Weisman LS
Structural insights into transcriptional regulation by the helicase RECQL5.
1. Nat Struct Mol Biol - published July 7, 2025
2. Florez Ariza AJ, Lue NZ, Grob P, Kaeser B, Fang J, Kassube SA, Nogales E
Auto-aggregation in Streptococcus intermedius is driven by the Pel polysaccharide.
1. mBio - published July 7, 2025
2. Raju D, Turner SA, Castro K, Whitfield GB, Lamarche D, Mahajan S, Pfoh R, Chuang SH, Le Mauff F, Joe M, Sarkar S, Lowary TL, Sheppard DC, Wozniak DJ, Surette MG, Howell PL
The C-terminus of the multi-drug efflux pump EmrE prevents proton leak by gating transport.
1. Elife - published July 7, 2025
2. Brousseau M, Teng D, Thomas NE, Voth GA, Henzler-Wildman KA
Huaganjian decoction ameliorates metabolic dysfunction-associated steatotic liver disease through liver-gut crosstalk.
1. J Ethnopharmacol - published July 7, 2025
2. Dong Q, Wang Y, He Y, Gao T, Li L, Chen L, Liu C, Wang W, Liu X, Zhang Y, Cui Y, Zeng J, Li M, Yan X, Fu C, Liao W, Wen J
Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer.
1. bioRxiv - published July 7, 2025
2. Koochaki P, Qiu B, Coker JA, Earsley A, Wang NS, Romigh T, Goins CM, Stauffer SR, Boudker O, Chakraborty AA
Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity.
1. bioRxiv - published July 6, 2025
2. Greene E, Muniz R, Yamamura H, Hoff SE, Bajaj P, Lee DJ, Thompson EM, Arada A, Lee GM, Bonomi M, Kollman JM, Fraser JS
Development and validation of a short version of the Hypomanic Attitudes and Positive Predictive Inventory (HAPPI): Measuring extreme appraisals of internal states and bipolar risk.
1. J Affect Disord - published July 5, 2025
2. Sperry SH, Smith JL, Sandorffy BL, Murphy VA, Kim H, Van Rheenen TE, Dodd A
A Computational Workflow for Structure-Guided Design of Potent and Selective Kinase Peptide Substrates.
1. bioRxiv - published July 5, 2025
2. Yekeen AA, Meyer CJ, McCoy M, Posner B, Westover KD
Discovery of oxyacanthine dihydrochloride monohydrate polymorphs from obfuscated samples by MicroED.
1. bioRxiv - published July 5, 2025
2. Lin J, Paz O, Unge J, Gonen T
Two parallel lineage-committed progenitors contribute to the developing brain.
1. bioRxiv - published July 5, 2025
2. Dundes CE, Jokhai RT, Ahsan H, Kang RS, Salomon-Shulman REA, Rajan A, Kim YS, Stanton LJ, Xu C, Do S, McDonald BD, López JMA, Urrutia HA, Greenfeld H, Wong A, Qu Y, Petkovic AS, Miao Y, Garcia KC, Monje M, Wagner DE, Bronner ME, Lowe CJ, Loh KM
Small Molecule Regulation of Iron Homeostasis: Design and Optimization of Novel Iron Chelators Based on a Thiosemicarbazone Scaffold.
1. J Mol Struct - published July 5, 2025
2. Parry CS, Li Y, Kwofie SK, Valencia J, Tope Niedermaier CA, Ramadhar TR, Nekhai S, Wilson MD, Butcher RJ
Crystal structures and low-affinity complex formation of halogenase CtcP and FAD reductase CtcQ from the chlortetracycline biosynthetic pathway.
1. Biosci Rep - published July 4, 2025
2. Hou C, Garneau-Tsodikova S, Tsodikov OV
The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases.
1. Nat Commun - published July 4, 2025
2. Sastre DE, Bournazos S, Huliciak M, Grace BAC, Boder EJ, Du J, Sultana N, Azzam T, Brown TJ, Flowers MW, Lollar P, Xu T, Chernova TA, Keith AD, Keen M, Saltzman A, Martinez Gascueña A, Trastoy B, Guerin ME, Frank F, Ortlund EA, Ravetch JV, Sundberg EJ
Small molecule OPA1 inhibitors amplify cytochrome c release and reverse cancer cells resistance to Bcl-2 inhibitors.
1. Sci Adv - published July 4, 2025
2. Pellattiero A, Quirin C, Magrin F, Sturlese M, Fracasso A, Biris N, Herkenne S, Cendron L, Gavathiotis E, Moro S, Mattarei A, Scorrano L
MIC: A deep learning tool for assigning ions and waters in cryo-EM and crystal structures.
1. Nat Commun - published July 4, 2025
2. Shub L, Liu W, Skiniotis G, Keiser MJ, Robertson MJ
Phrixotoxin-3 binds to three distinct antagonistic sites on human Na(v)1.6.
1. Cell Res - published July 4, 2025
2. Fan X, Chen J, Huang X, Hou Z, Xie Y, Li Z, Yan N, Huang J
TMC1 and TMC2 are cholesterol-dependent scramblases that regulate membrane homeostasis in auditory hair cells.
1. bioRxiv - published July 4, 2025
2. Lee H, Park YC, Wen H, Smith HE, Balaraman J, Cui R, Sotomayor M, Ballesteros A
Structural and Functional Mechanisms Underlying Activation Gate Dynamics and IFM Motif Accessibility in Human Na(v)1.5.
1. bioRxiv - published July 4, 2025
2. Biswas R, López-Serrano AL, Purohit A, Ramirez-Navarro A, Huang HL, Cheng X, Heissler SM, Deschênes I, Chinthalapudi K
Mechanism of cotranslational protein N-myristoylation in human cells.
1. Mol Cell - published July 4, 2025
2. Gamerdinger M, Echeverria B, Lentzsch AM, Burg N, Fan Z, Jaskolowski M, Scaiola A, Piening S, Shan SO, Ban N, Deuerling E
Detection of Feline Coronavirus RNA in Cats with Feline Infectious Peritonitis and Their Housemates.
1. Viruses - published July 4, 2025
2. Shepherd PM, Elbe A, Lynch BM, Lashnits E, Kirchdoerfer RN
Efficacy of the 4 Subclasses of IgG for Interacting With CD32b/a on Human Basophils.
1. Clin Exp Allergy - published July 3, 2025
2. MacGlashan D Jr, Spiller BW, Smith SA
Assembly mechanism of the snRNA nuclear export complex.
1. Nat Struct Mol Biol - published July 3, 2025
2. Xie Y, Ren Y
Marburg virus glycoprotein mRNA vaccine is more protective than a virus-like particle-forming mRNA vaccine.
1. J Clin Invest - published July 3, 2025
2. Subramani C, Meyer MN, Hyde MA, Comeaux ME, Hao H, Crowe JE Jr, Popov VL, Thaker H, Himansu S, Carfi A, Bukreyev A
Cellular metabolite sensors: Arginine? It's in the bag!
1. Mol Cell - published July 3, 2025
2. Jackson TD, Palozzi JM, Puigserver P
PCNA is a Nucleotide Exchange Factor for the Clamp Loader ATPase Complex.
1. bioRxiv - published July 3, 2025
2. Pajak J, Landeck JT, Liu X, Anand K, Litvak S, Kelch BA
Physical and functional interaction of Lrrc56 and Odad3 controls deployment of axonemal dyneins in vertebrate multiciliated cells.
1. bioRxiv - published July 3, 2025
2. Reyes-Nava NG, Lee C, Papoulas O, Hong J, Marcotte EM, Wallingford JB
FimX regulates type IV pilus localization via the Pil-Chp chemosensory system in Acinetobacter baylyi.
1. Mol Biol Cell - published July 3, 2025
2. Ellison TJ, Yen IY, Howell PL, Ellison CK
Bond-centric modular design of protein assemblies.
1. Nat Mater - published July 3, 2025
2. Wang S, Favor A, Kibler RD, Lubner JM, Borst AJ, Coudray N, Redler RL, Chiang HT, Sheffler W, Hsia Y, Bethel NP, Li Z, Ekiert DC, Bhabha G, Pozzo LD, Baker D
A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas.
1. Nat Commun - published July 3, 2025
2. Apfelbaum AA, Morin E, Sturm D, Ayoub G, DiGiacomo J, Bahadur S, Chandarana B, Power PC, Cusick MM, Novikov D, Prabhakar P, Jones RE, Vogelzang J, Bossi CC, Malinowski S, Woodward LM, Jones TA, Jeang J, Lamson SW, Collins J, Cai KY, Jones JS, Oh S, Jeon H, Wang J, Cameron A, Rechter P, De Leon A, Murugesan K, Montesion M, Albacker LA, Ramkissoon SH, van Tilburg CM, Hardin EC, Sievers P, Sahm F, Yeo KK, Rosenberg T, Chi SN, Wright KD, Hébert S, Peck S, Picca A, Larouche V, Renzi S, Buhrlage SJ, Bale TA, Smith AA, Touat M, Jabado N, Fischer ES, Eck MJ, Baird L, Witt O, Kleinman CL, Nguyen QD, Sheer D, Alexandrescu S, Jones DTW, Ligon KL, Bandopadhayay P
Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase.
1. Nat Commun - published July 3, 2025
2. Skeens E, Maschietto F, Manjula R, Shillingford S, Murphy J, Lolis EJ, Batista VS, Bennett AM, Lisi GP
Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2.
1. J Biol Chem - published July 3, 2025
2. Ross P, Hilton HG, Lodwick J, Slezak T, Guethlein LA, McMurtrey CP, Han AS, Nielsen M, Yong D, Dulberger CL, Nolan KT, Roy S, Castro CD, Hildebrand WH, Zhao M, Kossiakoff A, Parham P, Adams EJ
Sialic Acid Identity Modulates Host Tropism of Sialoglycan-binding Viridans Group Streptococci.
1. J Biol Chem - published July 3, 2025
2. Morrison KM, Agarwal R, Stubbs HE, Yu H, Ruhl S, Chen X, Sullam PM, Bensing BA, Smith JC, Iverson TM
25 years of Ebola Virus VP35 Research.
1. J Mol Biol - published July 3, 2025
2. Uwase G, Leung DW, Amarasinghe GK
Uropathogenic Escherichia coli niche occupancy determines the effects of mucosal vaccine against FimH.
1. Cell Rep - published July 3, 2025
2. Santiago-Borges JM, Rosen AL, Hernandez-Leyva A, Tomera CP, Lint MA, Paharik AE, Vanyo V, Pinkner JS, Dodson KW, Chen SL, Hsieh CS, Hultgren SJ, Kau AL
Cooperativity and Communication between the Active Sites of the Dimeric SARS-CoV-2 Main Protease.
1. bioRxiv - published July 3, 2025
2. Zvornicanin SN, Shaqra AM, Flynn J, Intravaia LE, Martinez HC, Jia W, Gupta DK, Moquin S, Dovala D, Bolon DN, Kelch BA, Schiffer CA, Yilmaz NK
ADCY3 Ser107Pro links difficulty awakening in the morning to adiposity through circadian regulation of adipose thermogenesis.
1. bioRxiv - published July 3, 2025
2. Tchio C, Maher M, Moth C, Meiler J, Lane J, Taylor H, Williams J, Saxena R
UBR-1 enzyme network regulates glutamate homeostasis to affect organismal behavior and developmental viability.
1. bioRxiv - published July 3, 2025
2. Pak JS, Morrone S, Opperman KJ, Midha MK, Kapil C, Mathew ND, Page DT, Zheng N, Moritz RL, Grill B
Programmable Liposome Organization via DNA Origami Templates.
1. J Am Chem Soc - published July 2, 2025
2. Zhang Z, Feng Z, Zhao X, Yu Z, Chapman ER
Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons.
1. Nat Commun - published July 2, 2025
2. Edmonds KK, Wilkinson ME, Strebinger D, Chen H, Lash B, Schaefer CC, Zhu S, Liu D, Zilberzwige-Tal S, Ladha A, Walsh ML, Frangieh CJ, Vaz Reay NA, Macrae RK, Wang X, Zhang F
FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells.
1. Sci Rep - published July 2, 2025
2. Feng Y, Barbulescu P, Chana CK, Shirdarreh M, Yang H, Wu L, Mamand S, Kashem M, Zia A, Han M, Tsao J, Pugh T, Cescon D, Schatz DG, Sicheri F, Martin A, Pezo RC
SNARE disassembly requires Sec18/NSF side loading.
1. Nat Struct Mol Biol - published July 2, 2025
2. Khan YA, White KI, Pfuetzner RA, Singal B, Esquivies L, Mckenzie G, Liu F, DeLong K, Choi UB, Montabana E, Mclaughlin T, Wickner WT, Brunger AT
Structural and functional characterization of CREB-binding protein (CREBBP) as a histone propionyltransferase.
1. J Biol Chem - published July 2, 2025
2. Cui G, Ley M, Mechaly AE, Bui LC, Michail C, Berthelet J, Dairou J, Yang H, Chevreux G, Moroy G, Green MR, Haouz A, Lima FR
Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity.
1. Cell Chem Biol - published July 2, 2025
2. Nardella F, Jiang T, Wang L, Bohmer MJ, Chakraborty S, Okombo J, Calla J, Silva TM, Pazicky S, Che J, Jeon J, Vincent E, Boonyalai N, Coyle R, Buchanan MJ, Schaefer S, Chen D, Khan A, Mayville E, De Souza ML, Treat M, Charlton J, Tumwebaze PK, Tjia S, Montejo L, Cover K, Rosenthal PJ, Cooper RA, Bozdech Z, Lee MCS, Chakrabarti R, Desai SA, Fidock DA, Wang J, Gray NS, Winzeler EA, Chakrabarti D
Conformational flexibility of tubulin dimers regulates the transitions of microtubule dynamic instability.
1. bioRxiv - published July 2, 2025
2. Shred M, Vangos NE, Bayne AN, Tetlalmatzi SC, Peng W, Trempe JF, Sept D, Cianfrocco MA, Brouhard GJ
Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis.
1. Nat Commun - published July 2, 2025
2. Kim JS, Chen Z, Espinosa Garcia SA, Buhlheller C, Zhang B, Richards SJ, Chen T, Wu J, Bruntz RC, Gilliam ME, Yamauchi M, Liang B, Guo H
The hit-and-run of cell wall synthesis: LpoB transiently binds and activates PBP1b through a conserved allosteric switch.
1. Nat Commun - published July 2, 2025
2. Shlosman I, Vettiger A, Bernhardt TG, Kruse AC, Loparo JJ
Structural insights into the roles of PARP4 and NAD(+) binding in the human vault cage.
1. Nat Commun - published July 2, 2025
2. Lodwick JE, Shen R, Erramilli S, Xie Y, Roganowicz K, Ritchey S, Kossiakoff AA, Zhao M
Cryo-EM Visualization of Intermolecular π-Electron Interactions within π-Conjugated Peptidic Supramolecular Polymers.
1. ACS Macro Lett - published July 2, 2025
2. Rich-New ST, Wang R, Zia A, Wang F, Tovar JD
Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex.
1. Nat Commun - published July 2, 2025
2. Sun Y, Wang Y, Xing Z, Li D, Wang R, Chen B, Zhou N, Ayala A, Tu BP, Qi X
Structural Basis for Postfusion-Specific Binding to the Respiratory Syncytial Virus F Protein by the Canonical Antigenic Site I Antibody 131-2a.
1. ACS Infect Dis - published July 2, 2025
2. Peng W, Šiborová M, Wu X, Du W, Schulte D, Pronker MF, de Haan CAM, Snijder J
Design of Antigen-Targeting Fluorogenic Probes Utilizing Intramolecular Addition Reaction of Protein-Dye Hybrids.
1. J Am Chem Soc - published July 2, 2025
2. Nakadate M, Kojima R, Seike N, Tachibana R, Fujita K, Tsuchiya R, Kamiya M, Plückthun A, Urano Y
A Cooperative Model for Symmetric Ligand Binding to Protein Fibrils.
1. Biochemistry - published July 2, 2025
2. Smith MS, DeGrado WF, Grabe M, Shoichet BK
Ultrahigh-resolution solid-state NMR for high-molecular weight proteins on GHz-class spectrometers.
1. Sci Adv - published July 2, 2025
2. Wang S, Ravula T, Stringer JA, Gor'kov PL, Warmuth OA, Williams CG, Thome AF, Mueller LJ, Rienstra CM
SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress.
1. Cell - published July 2, 2025
2. Wolin E, Guo JK, Blanco MR, Goronzy IN, Gorhe D, Dong W, Perez AA, Keskin A, Valenzuela E, Abdou AA, Urbinati CR, Kaufhold R, Rube HT, Brito Querido J, Guttman M, Jovanovic M
HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors.
1. Nat Commun - published July 2, 2025
2. Madel Alfajaro M, Keeler EL, Li N, Catanzaro NJ, Teng IT, Zhao Z, Grunst MW, Yount B, Schäfer A, Wang D, Kim AS, Synowiec A, Peña-Hernández MA, Zepeda S, Arinola R, Kaur R, Menasche BL, Wei J, Russell GA, Huck J, Song J, Ring A, Iwasaki A, Jangra RK, Lee S, Martinez DR, Mothes W, Uchil PD, Doench JG, Spaulding AB, Baric RS, Serebryannyy L, Tsybovsky Y, Zhou T, Douek DC, Wilen CB
The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation.
1. Cell Rep - published July 2, 2025
2. Joo YK, Parrado CR, Li W, Yang R, Black E, Bleichert F, Liu Y, Kabeche L
De novo design and structure of a peptide-centric TCR mimic binding module.
1. Science - published July 2, 2025
2. Householder KD, Xiang X, Jude KM, Deng A, Obenaus M, Zhao Y, Wilson SC, Chen X, Wang N, Garcia KC
Inhibitor Affinity Differs among Clinical Variants of IMP Metallo-β-Lactamases: Analysis and Implications for Inhibitor Design.
1. ACS Infect Dis - published July 2, 2025
2. Thomas CA, Alao JP, Smisek T, Cheng Z, Bethel CR, Yang K, Obaseki I, Page RC, Bonomo RA, Oelschlaeger P, Fast W, Kravats AN, Crowder MW
Secretogranin 2 binds LILRB4 resulting in immunosuppression.
1. Nat Immunol - published July 2, 2025
2. Yang X, Huang R, Fang M, He Y, Xie J, Liu X, Zhang C, Lou Q, Deng M, Xiong W, Lewis C, Sadek Z, Gupta A, Chen L, Zhang X, Guo L, Xu L, Zhang N, An Z, Zhang CC
Author Correction: Structures of KEOPS bound to tRNA reveal functional roles of the kinase Bud32.
1. Nat Commun - published July 2, 2025
2. Chuquimarca SMO, Beenstock J, Daou S, Porat J, Keszei AFA, Yin JZ, Beschauner T, Bayfield MA, Mazhab-Jafari MT, Sicheri F
Single-cell image-based screens identify host regulators of Ebola virus infection dynamics.
1. Nat Microbiol - published July 2, 2025
2. Carlson RJ, Patten JJ, Stefanakis G, Soong BY, Radhakrishnan A, Singh A, Thakur N, Sheehan KCF, Amarasinghe GK, Hacohen N, Basler CF, Leung DW, Uhler C, Davey RA, Blainey PC
Unveiling the hidden interactome of CRBN molecular glues.
1. Nat Commun - published July 2, 2025
2. Baek K, Metivier RJ, Roy Burman SS, Bushman JW, Yoon H, Lumpkin RJ, Ryan JK, Abeja DM, Lakshminarayan M, Yue H, Ojeda S, Xiong Y, Che J, Verano AL, Schmoker AM, Gray NS, Donovan KA, Fischer ES
Cryo-EM and cryo-ET reveal the molecular architecture and host interactions of mycobacteriophage Douge.
1. Cell Rep - published July 2, 2025
2. Maharana J, Wang CH, Tsai LA, Liao YT, Yang CH, Shen MC, Macale LS, Tran TN, Narsico J, Perez RJ, Tewary SK, Wu JL, Lin HY, Chang SW, Franklin A, Moynihan PJ, Jacobs-Sera D, Freeman KG, Hatfull GF, Lowary TL, Ho MC
Structural analysis of HER2-trastuzumab complex reveals receptor conformational adaptation.
1. Sci Adv - published July 2, 2025
2. Vacca S, Gragera M, Buschiazzo A, Herreros D, Krieger JM, Bonn-Garcia S, Melero R, Sorzano CO, Carazo JM, Medalia O, Plückthun A
Nucleosomes specify co-factor access to p53.
1. Mol Cell - published July 2, 2025
2. Chakraborty D, Sandate CR, Isbel L, Kempf G, Weiss J, Cavadini S, Kater L, Seebacher J, Kozicka Z, Stoos L, Grand RS, Schübeler D, Michael AK, Thomä NH
Melbournevirus encodes a shorter H2B-H2A doublet histone variant that forms structurally distinct nucleosome structures.
1. Nat Commun - published July 2, 2025
2. Villalta A, Bisio H, Toner CM, Abergel C, Luger K
EnsembleFlex: Protein structure ensemble analysis made easy.
1. Structure - published July 2, 2025
2. Schneider M, Marquez JA, Leach AR
Ancestral sequence reconstruction as a tool for structural analysis of modular polyketide synthases.
1. Nat Commun - published July 2, 2025
2. Chisuga T, Takinami S, Liao Z, Karasawa M, Adachi N, Kawasaki M, Moriya T, Senda T, Terada T, Kudo F, Eguchi T, Nakano S, Ito S, Miyanaga A
Backbone assignment of a 28.5 kDa class A extended spectrum β-lactamase by high-field, carbon-detected solid-state NMR.
1. Biomol NMR Assign - published July 2, 2025
2. Williams CG, Wang S, Thome AF, Warmuth OA, Sakhrani V, Coates L, Rienstra CM, Mueller LJ
Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against evading flg22 epitopes.
1. Nat Plants - published July 2, 2025
2. Zhang S, Liu S, Lai HF, Bender KW, Kim G, Caflisch A, Zipfel C
Environmental cues in different host niches shape the survival fitness of Staphylococcus aureus.
1. Nat Commun - published July 2, 2025
2. Chang J, Lee C, Kim I, Kim J, Kim JH, Yun T, Hooper DC, Walker S, Lee W
Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects.
1. J Am Chem Soc - published July 2, 2025
2. Bravo E Jr, Li Y, Lin DY, Srinivasan B, Barone M, Li SX, DelloRusso F, Rahiyanath AS, Corrionero A, Alfonso P, Prendiville N, Kozakov D, Andreotti AH, Tonge PJ
Molecular Determinants of Mg(2+)-Mediated Inhibition in RyR1: Insights from Computational Approaches.
1. ACS Omega - published July 2, 2025
2. Boonamnaj P, Taweechat P, Lerttanakij P, Pandey RB, Samsó M, Sompornpisut P
Merbecovirus S2 subunit vaccines elicit cross reactive antibodies and provide partial protection against MERS coronavirus.
1. Npj Viruses - published July 2, 2025
2. Halfmann PJ, Lee JS, Duffy A, Huang B, Yang JE, Wright ER, Kawaoka Y, Kane RS
Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites.
1. Cell - published July 2, 2025
2. Zhang Z, Todeschini TC, Wu Y, Kogay R, Naji A, Cardenas Rodriguez J, Mondi R, Kaganovich D, Taylor DW, Bravo JPK, Teplova M, Amen T, Koonin EV, Patel DJ, Nobrega FL
Unconventional structure and function of PHD domains from additional sex combs-like proteins.
1. FEBS J - published July 2, 2025
2. Reddington CJ, Walsh AR, Kleffmann T, Göbl C, Mace PD
Cytochrome P450 2W1: Identification of New Inhibitors, Active Site Ligands, and Pharmacophores.
1. J Biol Chem - published July 2, 2025
2. Frydendall EK, Scott EE
Metagenomic selections reveal diverse antiphage defenses in human and environmental microbiomes.
1. Cell Host Microbe - published July 2, 2025
2. Rodriguez-Rodriguez L, Pfister J, Schuck L, Martin AE, Mercado-Santiago LM, Tagliabracci VS, Forsberg KJ
Quantifying Intracellular Distributions of HaloTag-Labeled Proteins With SDS-PAGE and Epifluorescence Microscopy.
1. Bio Protoc - published July 2, 2025
2. Shangguan J, Rock RS
Design of soluble Notch agonists that drive T cell development and boost immunity.
1. Cell - published July 2, 2025
2. Mout R, Jing R, Tanaka-Yano M, Egan ED, Eisenach H, Kononov MA, Windisch R, Najia MAT, Tompkins A, Hensch L, Bingham T, Gunage R, Zhao Y, Edman NI, Li C, Wang D, Schlaeger TM, Zon LI, North TE, Lendahl U, Rowe RG, Baker D, Blacklow SC, Daley GQ
Inverted chimeric RNAi molecules synergistically co-target MYC and KRAS in KRAS-driven cancers.
1. J Clin Invest - published July 2, 2025
2. Chareddy YS, Huggins HP, Sahoo SS, Stanland L, Gutierrez-Ford C, Whately KM, Edatt L, Azam SH, Fleming MC, Im J, Porrello A, Simmons I, Perry JL, Bowers AA, Egli M, Pecot CV
Cryogenic electron tomography and elemental analysis of mitochondrial granules in human retinal ganglion cells.
1. Structure - published July 2, 2025
2. Wu GH, Hou C, Thron A, Patel HR, Spillane L, Gupte SR, Yeung-Levy S, Gulati S, Booth C, Liao YJ, Chiu W
Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling.
1. bioRxiv - published July 2, 2025
2. Uwase G, Luthra P, Vogel OA, Batra J, La Rosa BA, Sheehan KCF, Khatavkar O, Payton JE, Davey RA, Krogan NJ, Basler CF, Leung DW, Amarasinghe GK
Huntingtin preserves mitochondrial genome integrity in neurons, which is impaired in Huntington's disease.
1. bioRxiv - published July 2, 2025
2. Pradhan S, Gaikwad S, Tsai CL, Smith C, Zhang N, Bush K, Chakraborty A, Yuan S, Choudhary S, Keene CD, Ellerby LM, Hazra TK, La Spada AR, Wairkar YP, Ashizawa T, Tainer JA, Pandita TK, Thompson LM, Sarkar PS
Preparing for successful protein crystallization experiments.
1. Acta Crystallogr F Struct Biol Commun - published July 1, 2025
2. Budziszewski GR, Stojanoff V, Bowman SEJ
Standards for MicroED.
1. Acta Crystallogr C Struct Chem - published July 1, 2025
2. Unge J, Nannenga BL, Oliver AG, Gonen T
Molecular contacts in self-assembling clusters of membrane proteins.
1. Proc Natl Acad Sci U S A - published July 1, 2025
2. Mandala VS, Fu Z, MacKinnon R
Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast.
1. Protein Sci - published July 1, 2025
2. Benning FMC, Bell TA, Nguyen TH, Syau D, Connell LB, Liao YT, Keating MP, Coughlin M, Nordstrom AEH, Ericsson M, daCosta CJB, Chao LH
In situ high-resolution cryo-EM reconstructions from CEMOVIS.
1. IUCrJ - published July 1, 2025
2. Elferich J, Kaminek M, Kong L, Odriozola A, Kukulski W, Zuber B, Grigorieff N
Heritable symbiont producing nonribosomal peptide confers extreme heat sensitivity and antifungal protection on its host.
1. Proc Natl Acad Sci U S A - published July 1, 2025
2. Maeda GP, Dang V, Kelly MK, Sundar A, Arnott RLW, Marcotte EM, Moran NA
Fabrication of RIG-I-Activating Nanoparticles for Intratumoral Immunotherapy via Flash Nanoprecipitation.
1. Mol Pharm - published July 1, 2025
2. Stone PT, Kwiatkowski AJ, Roth EW, Fedorova O, Pyle AM, Wilson JT
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.
1. Nat Commun - published July 1, 2025
2. Bourgeois B, Spreitzer E, Platero-Rochart D, Paar M, Zhou Q, Usluer S, de Keizer PLJ, Burgering BMT, Sánchez-Murcia PA, Madl T
Structural mechanism of DDX39B regulation by human TREX-2 and a related complex in mRNP remodeling.
1. Nat Commun - published July 1, 2025
2. Clarke BP, Gao S, Mei M, Xie D, Angelos AE, Vazhavilla A, Hill PS, Cagatay T, Batten K, Shay JW, Xie Y, Fontoura BMA, Ren Y
Divergent antibody recognition profiles are generated by protective mRNA vaccines against Marburg and Ravn viruses.
1. Nat Commun - published July 1, 2025
2. Meyer M, Gunn BM, Pietzsch C, Subramani C, Kedarinath K, Villarreal PP, Hyde MA, Saphire EO, Crowe JE Jr, Alter G, Himansu S, Carfi A, Bukreyev A
HIV-1 vif mediates ubiquitination of the proximal protomer in the APOBEC3H dimer to induce degradation.
1. Nat Commun - published July 1, 2025
2. Skorupka KA, Matsuoka K, Hassan B, Ghirlando R, Balachandran V, Chen TH, Walters KJ, Schiffer CA, Wolf M, Iwatani Y, Matsuo H
Visualizing DNA polymerase ι catalyze Hoogsteen-directed DNA synthesis.
1. Nat Commun - published July 1, 2025
2. Frevert Z, Reusch DT, Gildenberg MS, Jordan SM, Ryan BJ, Freudenthal BD, Washington MT
Visualization of a multi-turnover Cas9 after product release.
1. Nat Commun - published July 1, 2025
2. Kiernan KA, Taylor DW
Memantine inhibits calcium-permeable AMPA receptors.
1. Nat Commun - published July 1, 2025
2. Carrillo E, Montaño Romero A, Gonzalez CU, Turcu AL, Vázquez S, Twomey EC, Jayaraman V
Polarity protein Par6 facilitates the processive phosphorylation of Lgl via a dynamic interaction with aPKC.
1. Commun Biol - published July 1, 2025
2. Almagor L, Weis WI
The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture.
1. Nat Commun - published July 1, 2025
2. Vazquez N, Lee C, Valenzuela I, Phan TP, Derderian C, Chávez M, Mooney NA, Demeter J, Aziz-Zanjani MO, Cusco I, Codina M, Martínez-Gil N, Valverde D, Solarat C, Buel AL, Thauvin-Robinet C, Steichen E, Filges I, Joset P, De Geyter J, Vaidyanathan K, Gardner TP, Toriyama M, Marcotte EM, Drew K, Roberson EC, Jackson PK, Reiter JF, Tizzano EF, Wallingford JB
Flavoproteins as native and genetically encoded spin probes for in cell ESR spectroscopy.
1. Nat Commun - published July 1, 2025
2. Chauviré T, Chandrasekaran S, Dunleavy R, Freed JH, Crane BR
Molecular mechanism of Activin receptor inhibition by DLK1.
1. Nat Commun - published July 1, 2025
2. Antfolk D, Ming Q, Manturova A, Goebel EJ, Thompson TB, Luca VC
Bioremediation of diesel-contaminated saline soil and enhancement of microbial salinity tolerance by a biosurfactant-producing Bacillus subtilis AHV-KH11 and external surfactant application: bio-toxicity assessment.
1. Sci Rep - published July 1, 2025
2. Barzegar G, Jorfi S, Sanaei D, Rezaei M, Jokar R, Sharifan H, Jafari K, Biswas JK
Structural basis of voltage-dependent gating in BK channels.
1. Nat Commun - published July 1, 2025
2. Contreras GF, Shen R, Latorre R, Perozo E
The Hidden Cost of Being Uninsured: Stroke Mortality After Mechanical Thrombectomy.
1. J Stroke Cerebrovasc Dis - published July 1, 2025
2. Lyons AT, Davis J, Bishay AE, Bhamidipati A, Longo M, Ahn S, Bendfeldt G, Gangavarapu LS, Ye E, Mummareddy N, Kamal N, Froehler MT, Chitale RV, Fusco MR
Learning with Privileged Knowledge Distillation for Improved Peptide-Protein Docking.
1. ACS Omega - published July 1, 2025
2. Zhang Z, Verburgt J, Kagaya Y, Christoffer C, Kihara D
Syntheses and structures of dinuclear zinc(II) acetate-bridged coordination compounds with the aromatic Schiff base chelators N,N-dimethyl-2-[phen-yl(pyridin-2-yl)methyl-idene]hydrazine-1-carbothio-amide and N-ethyl-2-[phen-yl(pyridin-2-yl)methyl-idene]hydrazine-1-carbo-thio-amide.
1. Acta Crystallogr E Crystallogr Commun - published July 1, 2025
2. Parry CS, Abraham AR, Kwofie SK, Wilson MD, Ramadhar TR, Butcher RJ
β-arrestin recruitment facilitates a direct association with G proteins.
1. bioRxiv - published July 1, 2025
2. Lee CY, Smith JS, Kohlmann T, Meara EM, Pham U, Kwarcinski F, Dates AN, Choi I, Hilibrand AS, Gillikin A, Blacklow SC, Tall GG, Kruse AC, Rajagopal S
Groove architecture controls lipid scrambling in simulations of protein and model systems.
1. bioRxiv - published July 1, 2025
2. Smith HE, Harrison-Rawn T, Zheng W, Ballesteros A, Sotomayor M
Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase.
1. Nat Commun - published July 1, 2025
2. Baytshtok V, DiMattia MA, Lima CD
Hypertensive disorders of pregnancy and perinatal outcomes: two prospective cohort studies of nulliparous women in India and Tanzania.
1. BMJ Glob Health - published July 1, 2025
2. Pembe AB, Dwarkanath P, Kikula A, Raj JM, Perumal N, Paulo HA, M R, Duggan CP, Masanja HM, Chopra N, Sando MM, Thomas T, Yelverton CA, Muhihi A, Kurpad AV, Fawzi WW, Wylie BJ, Sudfeld CR
Discovery of First-in-Class Inhibitors Targeting a Pathogen-Associated Aminoglycoside-Resistance 16S rRNA Methyltransferase.
1. ACS Infect Dis - published July 1, 2025
2. Dey D, Deprez BE, Zelinskaya N, Castro JM, Wuest WM, Conn GL
Advancements and Future Perspectives of Triphenylamine-Based Fluorescent Probes in Biomedical Applications.
1. Acta Biomater - published July 1, 2025
2. Ding Q, Li Y, Zhang N, Wang B, Qian K, Wang Q, Xiang C, Wang Y, Ma G, Gong P, Cheng Z, Tian J
Modulation of the PTPRS proteoglycan switch by antibodies binding to the membrane-proximal fibronectin-type III domain.
1. J Biol Chem - published July 1, 2025
2. Hein Da Rosa T, Ramsey SH, Lee JJ, Kozlova NY, Zhao Z, Kim J, Schneider AC, Li S, Katiki M, Firestein GS, Murali R, Santelli E, Stanford SM, Bottini N
Uptake of fucosylated type I human milk oligosaccharide blocks by Bifidobacterium longum subsp. infantis.
1. mBio - published July 1, 2025
2. Ejby Hansen M, Sakanaka M, Jensen M, Sakanaka H, Pichler MJ, Maeda S, Franck Høvring J, Nakajima A, Kunstmann S, Nielsen TS, Peters GHJ, Slotboom DJ, Morth JP, Katayama T, Abou Hachem M
Rapid detection and capture of clinical Escherichia coli strains mediated by OmpA-targeting nanobodies.
1. Commun Biol - published July 1, 2025
2. Sorgenfrei M, Hürlimann LM, Printz A, Wegner F, Morger D, Ackle F, Remy MM, Montowski G, Keserue HA, Cuénod A, Imkamp F, Egli A, Keller PM, Seeger MA
Inhibition of dimeric SARS-CoV-2 Mpro displays positive cooperativity and a mixture of covalent and non-covalent binding.
1. iScience - published July 1, 2025
2. Padmanabha Das KM, Chen J, Charifson PS, Green J, Tang H, Panchal S, Pu F, Korepanova A, Dubey A, Afanador G, Stojkovic V, Nocek B, Bigelow L, Stubbs SH, Davey RA, DeGoey DA, Arthanari H, Namchuk MN
Autophosphorylation of oncoprotein TEL-ABL in myeloid and lymphoid cells confers resistance to the allosteric ABL inhibitor asciminib.
1. Sci Signal - published July 1, 2025
2. Muratcioglu S, Eide CA, Hung CL, Gorday K, Sumpena E, Zuo W, Groves JT, Druker BJ, Kuriyan J
SuperMetal: a generative AI framework for rapid and precise metal ion location prediction in proteins.
1. J Cheminform - published July 1, 2025
2. Lin X, Su Z, Liu YL, Liu J, Kuang X, Cummings PT, Spencer-Smith J, Meiler J
Activated GDF11/8 subforms predict cardiovascular events and mortality in humans.
1. Nat Commun - published July 1, 2025
2. Walker RG, Kato T, Ben Driss L, Williams SA, Hinterberg MA, Janjic N, Gelinas AD, Carpenter MA, Kattamuri C, Walter JE, Mueller C, Mendello KR, Gordon JV, Walker KA, Coresh J, Bhasin S, Rubin LL, Wagers AJ, Thompson TB, Ganz P, Lee RT
Structure-Activity Relationships of Inactive-Conformation Binding EGFR Inhibitors: Linking the ATP and Allosteric Pockets.
1. Arch Pharm (Weinheim) - published July 1, 2025
2. Chitnis SP, Wittlinger F, Möllers M, Hartman TJ, Günther M, Eck MJ, Laufer SA, Heppner DE
Copper acquisition in Bacillus subtilis involves Cu(II) exchange between YcnI and YcnJ.
1. J Biol Chem - published July 1, 2025
2. Rafael de Oliveira Silva Y, Barnes G, Zheng D, Zhitnitsky D, Geathers SJ, Peters SC, Szalai VA, Helmann JD, Fisher OS
Structural basis of ClC-3 transporter inhibition by TMEM9 and PtdIns(3,5)P(2).
1. Nat Struct Mol Biol - published July 1, 2025
2. Schrecker M, Son Y, Planells-Cases R, Kar S, Vorobeva V, Schulte U, Fakler B, Jentsch TJ, Hite RK
Endocochlear potential contributes to hair cell death in TMPRSS3 hearing loss.
1. J Clin Invest - published July 1, 2025
2. Shearer AE, Chen YS, Rouse SL, Wang X, Marin Fermin J, Booth KT, Moawad J, Libiran NB, Li J, Kim HY, Hoa M, Olszewski R, Lei JY, Cabrera E, Totten DJ, Zhao B, Holt JR, Nelson RF
Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning.
1. Science - published July 1, 2025
2. Kaur U, Wu H, Cheng Y, Narlikar GJ
Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics.
1. Elife - published July 1, 2025
2. Peshkin L, Daldello EM, Van Itallie ES, Sonnett M, Kreuzer J, Haas W, Kirschner MW, Jessus C
Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype.
1. bioRxiv - published July 1, 2025
2. Samokhin AO, Seo HS, Leed A, Hajian B, Bird GH, McKinney DC, Saha P, Daum J, Moroco JA, Yehl J, Kornfilt D, Szczeniowski A, Petrunak E, Horner S, Kalin JH, Leymarie N, Kaushik VK, Walensky LD, Cole PA, Oldham WM, Steinhauser ML, Dhe-Paganon S, Maron BA
Disorder meets its match.
1. Science - published July 1, 2025
2. Moses AM, Forman-Kay JD
Structural determinants of DANGEROUS MIX 3, an alpha/beta hydrolase that triggers NLR-mediated genetic incompatibility in plants.
1. Mol Cell - published July 1, 2025
2. Wan WL, Kim G, Kim N, Tan YY, Watari M, Charoennit N, Lee RRQ, Phang IRK, Wang J, Liew YY, Hu D, Ng SK, Zhang Y, Jang IC, Song JJ, Chae E
Structural basis for sensitivity and acquired resistance of fungal cap guanine-N7 methyltransferases to the antifungal antibiotic sinefungin.
1. Nucleic Acids Res - published July 1, 2025
2. Nilson DJ, Schwer B, Almo SC, Shuman S, Ghosh A
Molecular mechanisms of biomolecular condensate formation in Drosophila melanogaster siRNA biogenesis.
1. Nucleic Acids Res - published July 1, 2025
2. Hipp C, Mussgnug S, Choudhary P, Kang HS, Asami S, Sastre J, Donau C, Böttcher R, Gemmecker G, Boekhoven J, Förstemann K, Sattler M
A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines.
1. Eur J Hum Genet - published July 1, 2025
2. White SM, Wondergem AP, Breet I, Dittmaier M, Bell K, Richmond CM, Hardikar W, Bhatia K, Quinlan C, Orchard D, D'Souza A, Chazin WJ, Smith C, Sparkes R, Lam S, Carter A, Hopkin RJ, Khendek L, Sullivan BR, Becher N, Simonsen AKW, Kvistgaard H, Dempsey K, Miethke AG, Gregersen PA, Phillips E, Luijsterburg MS
Cryo-EM structures of Nipah virus polymerases and high-throughput RdRp assay development enable anti-NiV drug discovery.
1. Nat Commun - published July 1, 2025
2. Chen Z, Quirit Dudley J, Deniston C, Buffalo CZ, Patra D, Cao D, Hunt J, Rohaim A, Sengupta D, Wen L, Tsang T, Xie L, DiDonato M, Spraggon G, Clifton MC, Jarrousse N, Straimer J, Liang B
The structure, folding kinetics, and dynamics of long poly(UG) RNA.
1. Nucleic Acids Res - published July 1, 2025
2. Petersen RJ, Vivek R, Tonelli M, Roschdi S, Butcher SE
The antigen presentation landscape of cytokine-stressed human pancreatic islets.
1. Cell Rep - published July 1, 2025
2. Nanaware PP, Calvo-Calle JM, Redick SD, Tarpley MW, Cruz J, Clement CC, Manganaro A, Velarde de la Cruz EE, Muneeruddin K, Faulkner M, Wang JP, Shaffer SA, Harlan DM, Santambrogio L, Kent SC, Stern LJ
Identification of cognate recombination directionality factors for large serine recombinases by virtual pulldown.
1. Nucleic Acids Res - published July 1, 2025
2. Shin H, Holland A, Alsaleh A, Retiz AD, Pigli YZ, Taiwo-Aiyerin OT, Peña Reyes T, Bello AJ, Quan J, Tang W, Olorunniji FJ, Rice PA
Systematic, high-throughput characterization of bacteriophage gene essentiality on diverse hosts.
1. Cell Host Microbe - published July 1, 2025
2. Chen J, Nilsen ED, Chitboonthavisuk C, Corban JE, Yang M, Mo CY, Raman S
The Effect of Duck Breeds on Carcass Composition and Meat Quality at Different Slaughter Ages.
1. Animals (Basel) - published July 1, 2025
2. Wang L, Chen X, Yang Y, Ye S, Gong P, Wang Y, Zhai M, Wu Y, Qian Y
Accelerating structural dynamics through integrated research informatics.
1. Struct Dyn - published July 1, 2025
2. Eisenbraun B, Ho A, Meyer PA, Sliz P
Quantum mechanics-driven structure-activity relationship study of PEX5-PEX14 protein-protein interaction inhibitors based on a dibenzo[b,e]azepin-6(6H)-one scaffold.
1. Eur J Med Chem - published July 1, 2025
2. Nowacki M, Menezes F, Pykacz E, Popiołek M, Napolitano V, Krishna CK, Kalel VC, Erdmann R, Fröhlich T, Plettenburg O, Sattler M, Popowicz GM, Dawidowski M