Member Publications

Jump to specific year:

123 Member Publications for April 2025

Recent developments in cystic fibrosis drug discovery: where are we today?
1. Expert Opin Drug Discov - published April 9, 2025
2. Lopes-Pacheco M, Winters AG, Jackson JJ, Olson Rd JA, Kim M, Ledwitch KV, Tedman A, Jhangiani AR, Schlebach JP, Meiler J, Plate L, Oliver KE
Multimodal cell maps as a foundation for structural and functional genomics.
1. Nature - published April 9, 2025
2. Schaffer LV, Hu M, Qian G, Moon KM, Pal A, Soni N, Latham AP, Pontano Vaites L, Tsai D, Mattson NM, Licon K, Bachelder R, Cesnik A, Gaur I, Le T, Leineweber W, Palar A, Pulido E, Qin Y, Zhao X, Churas C, Lenkiewicz J, Chen J, Ono K, Pratt D, Zage P, Echeverria I, Sali A, Harper JW, Gygi SP, Foster LJ, Huttlin EL, Lundberg E, Ideker T
Advanced Nanoenabled Microalgae Systems: Integrating Oxidative Stress-Induced Metabolic Reprogramming and Enhanced Lipid Biosynthesis for Next-Generation Biofuel Production.
1. ACS Appl Bio Mater - published April 9, 2025
2. Salmeron Covarrubias LP, Beluri K, Mohammadi Y, Easmin N, Palacios OA, Sharifan H
Inducible FAK Loss but not FAK Inhibition in Endothelial Cells of PYK2-null Mice Activates p53 Tumor Suppressor to Prevent Tumor Growth.
1. Mol Biol Cell - published April 9, 2025
2. Chen XL, Ojalill M, Jean C, Tancioni I, Jiang S, Boyer A, Ozmadenci D, Uryu S, Tarin D, Schlessinger J, Stupack DG, Schlaepfer DD
Mapping the extracellular molecular architecture of the pAg-signaling complex with α-Butyrophilin antibodies.
1. Sci Rep - published April 9, 2025
2. Ramesh A, Roy S, Slezak T, Fuller J, Graves H, Mamedov MR, Marson A, Kossiakoff AA, Adams EJ
RNA Modifications and Prp24 Coordinate Lsm2-8 Binding Dynamics during S. cerevisiae U6 snRNP Assembly.
1. J Biol Chem - published April 9, 2025
2. Liu Y, Nomura Y, Butcher SE, Hoskins AA
PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor.
1. Proc Natl Acad Sci U S A - published April 8, 2025
2. Husremović T, Meier V, Piëch L, Siess KM, Antonioli S, Grishkovskaya I, Kircheva N, Angelova SE, Wenzl K, Brandstätter A, Veis J, Miočić-Stošić F, Anrather D, Hartl M, Truebestein L, Cerron-Alvan LM, Leeb M, Žagrović B, Hann S, Bock C, Ogris E, Dudev T, Irwin NAT, Haselbach D, Leonard TA
Structural basis for neutralizing antibody binding to pertussis toxin.
1. Proc Natl Acad Sci U S A - published April 8, 2025
2. Goldsmith JA, Nguyen AW, Wilen RE, Wijagkanalan W, McLellan JS, Maynard JA
The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel.
1. Proc Natl Acad Sci U S A - published April 8, 2025
2. Riel EB, Bu W, Joseph TT, Khajoueinejad L, Eckenhoff RG, Riegelhaupt PM
Identification of CD84 as a potent survival factor in acute myeloid leukemia.
1. J Clin Invest - published April 8, 2025
2. Zhu Y, Murtadha M, Liu M, Caserta E, Napolitano O, Nguyen LXT, Wang H, Moloudizargari M, Nigam L, Tandoh T, Wang X, Pozhitkov A, Su R, Lin X, Estepa MD, Pillai R, Song J, Sanchez JF, Fu YH, Zhang L, Li M, Zhang B, Li L, Kuo YH, Rosen S, Marcucci G, Williams JC, Pichiorri F
Expanding the binding space of argonaute-2: incorporation of either E or Z isomers of 6'-vinylphosphonate at the 5' end of the antisense strand improves RNAi activity.
1. Chem Commun (Camb) - published April 8, 2025
2. Datta D, Kundu J, Miller P, Khan MS, Salinas J, Qin J, LeBlanc S, Nguyen T, Peng H, Theile CS, Egli M, Manoharan M
PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration.
1. Nat Commun - published April 8, 2025
2. Ahmad S, Zou T, Hwang J, Zhao L, Wang X, Davydenko A, Buchumenski I, Zhuang P, Fishbein AR, Capcha-Rodriguez D, Orgel A, Levanon EY, Myong S, Chou J, Meyerson M, Hur S
APOBEC3G Antagonism by Vif, or When Structure Meets Biological and Evolutionary Studies.
1. Annu Rev Virol - published April 8, 2025
2. Li YL, Langley C, Emerman M, Gross JD
In danger: HIV vaccine research and development in Europe.
1. PLOS Glob Public Health - published April 8, 2025
2. Tatoud R, Lévy Y, Le Grand R, Alcami J, Barbareschi G, Brander C, Cara A, Combadière B, Dabis F, Fidler S, Hanke T, Herrera C, Karlsson Hedestam GB, Kuipers H, McCormack S, Moog C, Pantaleo G, Richert L, Sanders RW, Shattock R, Streeck H, Thiebaut R, Trkola A, Üeberla K, Van Gills MJ, Wagner R, Weissenhorn W, Yazdanpanah Y, Scarlatti G, Lelièvre JD
Integrated analysis of transcriptional and metabolic responses to mitochondrial stress.
1. Cell Rep Methods - published April 8, 2025
2. Kelley LP, Hu SH, Boswell SA, Sorger PK, Ringel AE, Haigis MC
Structural diversity and oligomerization of bacterial ubiquitin-like proteins.
1. Structure - published April 8, 2025
2. Gong M, Ye Q, Gu Y, Chambers LR, Bobkov AA, Arakawa NK, Matyszewski M, Corbett KD
The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux.
1. J Cell Biol - published April 7, 2025
2. North BJ, Ohnstad AE, Ragusa MJ, Shoemaker CJ
Cytoplasmic ribosomes on mitochondria alter the local membrane environment for protein import.
1. J Cell Biol - published April 7, 2025
2. Chang YT, Barad BA, Hamid J, Rahmani H, Zid BM, Grotjahn DA
Regulation, structure, and activity of the Pseudomonas aeruginosa MexXY efflux system.
1. Antimicrob Agents Chemother - published April 7, 2025
2. Kavanaugh LG, Hinrichsen ME, Dunham CM, Conn GL
A structural and mechanistic model for BSEP dysfunction in PFIC2 cholestatic disease.
1. Commun Biol - published April 7, 2025
2. Gruget C, Reddy BG, Moore JM
Molecular mechanism of PP2A/B55α phosphatase inhibition by IER5.
1. Cell Chem Biol - published April 7, 2025
2. Cao R, Jones DTD, Pan L, Yang A, Wang S, Padi SKR, Rawson S, Aster JC, Blacklow SC
Global structural survey of the flagellotropic myophage φTE infecting agricultural pathogen Pectobacterium atrosepticum.
1. Nat Commun - published April 5, 2025
2. Hodgkinson-Bean J, Ayala R, Jayawardena N, Rutter GL, Watson BNJ, Mayo-Muñoz D, Keal J, Fineran PC, Wolf M, Bostina M
scRNA-seq uncovers the transcriptional dynamics of Encephalitozoon intestinalis parasites in human macrophages.
1. Nat Commun - published April 5, 2025
2. Jaroenlak P, McCarty KL, Xia B, Lam C, Zwack EE, Almasri NL, Sudar J, Aubry M, Yanai I, Bhabha G, Ekiert DC
Structural architecture of TolQ-TolR inner membrane protein complex from opportunistic pathogen Acinetobacter baumannii.
1. Sci Adv - published April 4, 2025
2. Karimullina E, Guo Y, Khan HM, Emde T, Quade B, Di Leo R, Otwinowski Z, Tieleman DP, Borek D, Savchenko A
Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50.
1. mBio - published April 4, 2025
2. Zvornicanin SN, Shaqra AM, Flynn J, Carias Martinez H, Jia W, Moquin S, Dovala D, Bolon DN, Kurt Yilmaz N, Schiffer CA
Proline-based tripodal cages with guest-adaptive features for capturing hydrophilic and amphiphilic fluoride substances.
1. Nat Commun - published April 4, 2025
2. Huang B, Li S, Pan C, Li F, Wojtas L, Qiao Q, Tran TH, Calcul L, Liu W, Ke C, Cai J
An End-to-End General Language Model (GLM)-4-Based Milling Cutter Fault Diagnosis Framework for Intelligent Manufacturing.
1. Sensors (Basel) - published April 4, 2025
2. He J, Liu X, Lei Y, Cao A, Xiong J
TIR domains produce histidine-ADPR as an immune signal in bacteria.
1. Nature - published April 3, 2025
2. Sabonis D, Avraham C, Chang RB, Lu A, Herbst E, Silanskas A, Vilutis D, Leavitt A, Yirmiya E, Toyoda HC, Ruksenaite A, Zaremba M, Osterman I, Amitai G, Kranzusch PJ, Sorek R, Tamulaitiene G
A MERS-CoV-like mink coronavirus uses ACE2 as entry receptor.
1. Nature - published April 3, 2025
2. Wang N, Ji W, Jiao H, Veit M, Sun J, Wang Y, Ma X, Wang Y, Wang Y, Li XX, Zhang X, Chen J, Wei J, Xu Y, Guo D, Zhai X, Merits A, Li C, Rey FA, Dobrikov GM, Gao GF, Zhang S, Bi Y, Su S
A DNA-gated molecular guard controls bacterial Hailong anti-phage defence.
1. Nature - published April 3, 2025
2. Tan JMJ, Melamed S, Cofsky JC, Syangtan D, Hobbs SJ, Del Marmol J, Jost M, Kruse AC, Sorek R, Kranzusch PJ
Efficient Direct Cytosolic Protein Delivery via Protein-Linker Co-engineering.
1. ACS Appl Mater Interfaces - published April 3, 2025
2. Wei L, Wang H, Özkan M, Damian-Buda AI, Loynachan CN, Liao S, Stellacci F
VAC14 oligomerization is essential for the function of the FAB1/PIKfyve-VAC14-FIG4 complex.
1. Mol Biol Cell - published April 3, 2025
2. Zhang L, Uygun T, Hahn HJ, Liu Y, Rivero-Ríos P, Li D, Navratna V, Bristow E, Luo G, Kovarzin A, Bo Y, Gadde S, Côté M, Ko DC, Mosalaganti S, Reinisch KM, Weisman LS
ZNF574 is a quality control factor for defective ribosome biogenesis intermediates.
1. Mol Cell - published April 3, 2025
2. Akers JF, LaScola M, Bothe A, Suh H, Jung C, Stolp ZD, Ghosh T, Yan LL, Wang Y, Macurak M, Devan A, McKinney MC, Grismer TS, Reyes AV, Ross EJ, Hu T, Xu SL, Ban N, Kostova KK
The RAD52 double-ring remodels replication forks restricting fork reversal.
1. Nature - published April 2, 2025
2. Honda M, Razzaghi M, Gaur P, Malacaria E, Marozzi G, Di Biagi L, Aiello FA, Paintsil EA, Stanfield AJ, Deppe BJ, Gakhar L, Schnicker NJ, Spies MA, Pichierri P, Spies M
Acyltransferases that Modify Cell Surface Polymers Across the Membrane.
1. Biochemistry - published April 2, 2025
2. Schultz BJ, Walker S
A Putative Binding Model of Nitazene Derivatives at the μ-Opioid Receptor.
1. Neuropharmacology - published April 2, 2025
2. Clayton J, Shi L, Robertson MJ, Skiniotis G, Michaelides M, Stavitskaya L, Shen J
RNA sculpting by the primordial Helix-clasp-Helix-Strand-Loop (HcH-SL) motif enforces chemical recognition enabling diverse KH domain functions.
1. J Biol Chem - published April 2, 2025
2. Tainer JA, Tsutakawa SE
Structural basis for plasticity in receptor engagement by an encephalitic alphavirus.
1. Cell - published April 2, 2025
2. Raju S, Palakurty S, Sariol A, Wagoner N, Adams LJ, Hui S, Klimstra WB, Fremont DH, Diamond MS
The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability.
1. Proc Natl Acad Sci U S A - published April 2, 2025
2. Forslund JME, Nguyen TVH, Parkash V, Berner A, Goffart S, Pohjoismäki JLO, Wanrooij PH, Johansson E, Wanrooij S
Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryoelectron tomography.
1. Proc Natl Acad Sci U S A - published April 2, 2025
2. Huang QJ, Kim R, Song K, Grigorieff N, Munro JB, Schiffer CA, Somasundaran M
The pentameric chloride channel BEST1 is activated by extracellular GABA.
1. Proc Natl Acad Sci U S A - published April 2, 2025
2. Pant S, Tam SW, Long SB
Structural basis of excitatory amino acid transporter 3 substrate recognition.
1. Proc Natl Acad Sci U S A - published April 2, 2025
2. Qiu B, Boudker O
Gasdermin D pores hitch a ride: extracellular vesicles spread pyroptosis.
1. Cell Res - published April 2, 2025
2. Du G, Wu H
A diverse single-stranded DNA-annealing protein library enables efficient genome editing across bacterial phyla.
1. Proc Natl Acad Sci U S A - published April 2, 2025
2. Filsinger GT, Mychack A, Lyerly E, Henriksen C, Bartlett TM, Kuchwara H, Eitzinger S, Bernhardt TG, Walker S, Church GM, Wannier TM
Blood pressure reduction and all-cause dementia in people with uncontrolled hypertension: an open-label, blinded-endpoint, cluster-randomized trial.
1. Nat Med - published April 2, 2025
2. He J, Zhao C, Zhong S, Ouyang N, Sun G, Qiao L, Yang R, Zhao C, Liu H, Teng W, Liu X, Wang C, Liu S, Chen CS, Williamson JD, Sun Y
Real-space heterogeneous reconstruction, refinement, and disentanglement of CryoEM conformational states with HetSIREN.
1. Nat Commun - published April 2, 2025
2. Herreros D, Mata CP, Noddings C, Irene D, Krieger J, Agard DA, Tsai MD, Sorzano COS, Carazo JM
On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents.
1. J Med Chem - published April 2, 2025
2. Kryštůfek R, Verner V, Šácha P, Hadzima M, Trajhan F, Starková J, Tloušt'ová E, Dvořáková A, Pecina A, Brynda J, Chalupský K, Hájek M, Boucher MJ, Majer P, Řezáč J, Madhani HD, Craik CS, Konvalinka J
Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases.
1. Vaccine - published April 2, 2025
2. Finney J, Kuraoka M, Song S, Watanabe A, Liang X, Liao D, Moody MA, Walter EB, Harrison SC, Kelsoe G
Proteostasis landscapes of cystic fibrosis variants reveal drug response vulnerability.
1. Proc Natl Acad Sci U S A - published April 2, 2025
2. McDonald EF, Kim M, Olson JA 3rd, Meiler J, Plate L
Conformational changes in the motor ATPase CpaF facilitate a rotary mechanism of Tad pilus assembly.
1. Nat Commun - published April 2, 2025
2. Yen IY, Whitfield GB, Rubinstein JL, Burrows LL, Brun YV, Howell PL
Switch II pocket inhibitor allosterically freezes KRAS(G12D)nucleotide-binding site and arrests the GTPase cycle.
1. J Mol Biol - published April 2, 2025
2. Kim HN, Gasmi-Seabrook GMC, Uchida A, Gebregiworgis T, Marshall CB, Ikura M
Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry.
1. Elife - published April 2, 2025
2. Schulte D, Šiborová M, Käll L, Snijder J
Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodies.
1. Sci Adv - published April 2, 2025
2. Maurer DP, Vu M, Ferreira Ramos AS, Dugan HL, Khalife P, Geoghegan JC, Walker LM, Bajic G, Schmidt AG
Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus M(Pro) inhibitors with potent in vivo efficacy.
1. Sci Adv - published April 2, 2025
2. Detomasi TC, Degotte G, Huang S, Suryawanshi RK, Diallo A, Lizzadro L, Zaptero-Belinchón FJ, Taha TY, Li J, Richards AL, Hantz ER, Alam Z, Montano M, McCavitt-Malvido M, Gumpena R, Partridge JR, Correy GJ, Matsui Y, Charvat AF, Glenn IS, Rosecrans J, Revalde JL, Anderson D, Hultquist JF, Arkin MR, Neitz RJ, Swaney DL, Krogan NJ, Shoichet BK, Verba KA, Ott M, Renslo AR, Craik CS
Activated blood-derived human primary T cells support replication of HAdV C5 and virus transmission to polarized human primary epithelial cells.
1. J Virol - published April 2, 2025
2. Sequeira DP, Suomalainen M, Freitag PC, Plückthun A, Klingenbrunner M, Fischer L, Hemmi S, Münz C, Volle R, Greber UF
Inactive structures of the vasopressin V2 receptor reveal distinct binding modes for Tolvaptan and Mambaquaretin toxin.
1. Nat Commun - published April 2, 2025
2. Fouillen A, Bous J, Couvineau P, Orcel H, Mary C, Lafleur L, Pierre T, Mendre C, Gilles N, Schulte G, Granier S, Mouillac B
Enhancing fluorescent probe design through multilayer interaction convolutional networks: advancing biosensing and bioimaging precision.
1. Chem Sci - published April 2, 2025
2. Ma G, Ding Q, Zhang Y, Zeng X, Zhu K, Chen H, Zhang W, Wang Q, Huang S, Gong P, Xu Z, Hong X
Regulation of the promoter for capsular polysaccharide synthesis in Neisseria meningitidis serogroup B by HTH_XRE family transcription factor.
1. Microbiol Spectr - published April 2, 2025
2. Sofowora I, McCarthy P, Wachira J
TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases.
1. Nat Commun - published April 2, 2025
2. Shulkina A, Hacker K, Ehrmann JF, Budroni V, Mandlbauer A, Bock J, Grabarczyk DB, Edobor G, Cochella L, Clausen T, Versteeg GA
Aliphatic Polyester Recognition and Reactivity at the Active Cleft of a Fungal Cutinase.
1. J Chem Inf Model - published April 2, 2025
2. Vidossich P, Manathunga M, Götz AW, Merz KM Jr, De Vivo M
Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins.
1. Nat Commun - published April 2, 2025
2. Zakrzewska S, Nixon SA, Chen Z, Hajare HS, Park ER, Mulcahy JV, Arlinghaus KM, Neu E, Konovalov K, Provasi D, Leighfield TA, Filizola M, Du Bois J, Minor DL Jr
In Quest of Chemical Probes for DNA Methylation Reader Proteins: Nucleoside and Dimer Analogues of 5-Methylcytosine Interact with MBD2.
1. Angew Chem Int Ed Engl - published April 2, 2025
2. Contreras J, Vichier-Guerre S, Dugué L, Bonhomme F, Jallet C, Nguyen MH, Vitorge B, Feoli A, Sbardella G, Guijarro JI, Arimondo P
Advances in uncovering the mechanisms of macromolecular conformational entropy.
1. Nat Chem Biol - published April 2, 2025
2. Wankowicz SA, Fraser JS
Twelfth scientific biennial meeting of the Australasian Virology Society: AVS12 2024.
1. J Virol - published April 2, 2025
2. Monson EA, Loterio RK, Roby JA, Adhikari A, Bull RA, Carr JM, Chatzileontiadou DSM, Cheng CX, Coulibaly F, Davis SK, Deerain JM, Douglas MW, Drummer HE, Eyre NS, Freppel W, Gowripalan A, Grant EJ, Gras S, Guthmiller JJ, Herrero LJ, Hesping E, Horsburgh BA, Hyde JL, Koutsakos M, Mackenzie JM, Mahar JE, McCoullough LC, McMillan CLD, Modhiran N, Parry RH, Purcell DFJ, Rawle DJ, Slonchak A, Speck PG, Tachedjian G, Tu T, Moseley GW, Fraser JE, Tate MD
Response: Promise and open questions of optogenetic vision restoration by MCO.
1. Mol Ther - published April 2, 2025
2. Mohanty SK, Mahapatra S, Batabyal S, Carlson M, Kanungo G, Ayyagari A, Tchedre K, Franco JA, Singer M, Barone S, Chavala S, Mahajan VB
The mechanism of peptidoglycan O-acetylation in Gram-negative bacteria typifies bacterial MBOAT-SGNH acyltransferases.
1. J Biol Chem - published April 2, 2025
2. Anderson AC, Schultz BJ, Snow ED, Brott AS, Stangherlin S, Malloch T, London JR, Walker S, Clarke AJ
3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN-2-Mediated Changes.
1. Aging Cell - published April 2, 2025
2. Scudese E, Marshall AG, Vue Z, Exil V, Rodriguez BI, Demirci M, Vang L, López EG, Neikirk K, Shao B, Le H, Stephens D, Hall DD, Rostami R, Rodman T, Kabugi K, Shao JQ, Mungai M, AshShareef ST, Hicsasmaz I, Manus S, Wanjalla CN, Whiteside A, Dasari R, Williams CR, Damo SM, Gaddy JA, Glancy B, Dantas EHM, Kinder A, Kadam A, Tomar D, Scartoni F, Baffi M, McReynolds MR, Phillips MA, Cooper A, Murray SA, Quintana AM, Wandira N, Ochayi OM, Ameka M, Kirabo A, Masenga SK, Harris C, Oliver A, Martin P, Gaye A, Korolkova O, Sharma V, Mobley BC, Katti P, Hinton A
Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA.
1. Mol Cell - published April 2, 2025
2. Bobadilla Ugarte P, Halter S, Mutte SK, Heijstek C, Niault T, Terenin I, Barendse P, Koopal B, Roosjen M, Boeren S, Hauryliuk V, Jinek M, Westphal AH, Swarts DC
Novel heterozygous SPI1c.538C>T p.(Leu180Phe) variant causes PU.1 haploinsufficiency leading to agammaglobulinemia.
1. Clin Immunol - published April 2, 2025
2. Daddali R, Kettunen K, Turunen T, Knox AVC, Laine P, Chowdhury I, Vänttinen M, Mamia N, Stiegler AL, Boggon TJ, Kere J, Romberg N, Seppänen MRJ, Varjosalo M, Martelius T, Grönholm J
Structural basis for regulation of CELSR1 by a compact module in its extracellular region.
1. Nat Commun - published April 2, 2025
2. Bandekar SJ, Garbett K, Kordon SP, Dintzner EE, Li J, Shearer T, Sando RC, Araç D
Intrinsically Disordered Peptide Nanofibers from A Structured Motif within Proteins.
1. Angew Chem Int Ed Engl - published April 2, 2025
2. Qiao Y, Zia A, Shy A, Wu G, Chu M, Liu Z, Wang F, Xu B
A single amino acid mutation alters multiple neutralization epitopes in the respiratory syncytial virus fusion glycoprotein.
1. Npj Viruses - published April 2, 2025
2. Oraby AK, Stojic A, Elawar F, Bilawchuk LM, McClelland RD, Erwin K, Granoski MJ, Griffiths CD, Frederick JD, Arutyunova E, Joanne Lemieux M, West FG, Ramilo O, Mejias A, McLellan JS, Marchant DJ
Contemporary insights into elamipretide's mitochondrial mechanism of action and therapeutic effects.
1. Biomed Pharmacother - published April 2, 2025
2. Sabbah HN, Alder NN, Sparagna GC, Bruce JE, Stauffer BL, Chao LH, Pitceathly RDS, Maack C, Marcinek DJ
An intranasally administered IgM protects against antigenically distinct subtypes of influenza A viruses.
1. Nat Commun - published April 2, 2025
2. Ramesh AK, Sivaccumar JP, Ye X, Yang L, Guo H, Chin CN, Ha S, Shiver JW, Strohl WR, Xu Y, Du H, Zhou T, Zhang N, Xu K, Liu X, Fu TM, An Z
A case for community metadata standards in cryo-electron tomography.
1. Emerg Top Life Sci - published April 2, 2025
2. Wan W
l-2,3-Diaminopropionate Binding Mode of the SulM Adenylation Domain Limits Engineering Monobactam Analogue Biosynthesis with Larger Substrates.
1. JACS Au - published April 2, 2025
2. Kahlert L, Patel KD, Lichstrahl MS, Li R, He C, Gulick AM, Townsend CA
Cryo-EM structure of coagulation factor Va bound to activated protein C.
1. Blood - published April 2, 2025
2. Mohammed BM, Basore K, Di Cera E
The crystal structures of apo and tryptophan-bound tryptophanyl-tRNA synthetase from Neisseria gonorrhoeae.
1. Acta Crystallogr F Struct Biol Commun - published April 1, 2025
2. Baral J, Song D, Edwards TE, Dranow DM, Lorimer DD, Staker BL, Myler P, Smith CL
Crystal structure of the S-adenosylmethionine-dependent mycolic acid synthase UmaA from Mycobacterium tuberculosis.
1. Acta Crystallogr F Struct Biol Commun - published April 1, 2025
2. Teng S, Wang J, Sroge CD, Abendroth J, Lorimer DD, Horanyi PS, Edwards TE, Tillery L, Craig JK, Van Voorhis WC, Myler PJ, Smith CL
Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity.
1. Nat Commun - published April 1, 2025
2. Planells-Cases R, Vorobeva V, Kar S, Schmitt FW, Schulte U, Schrecker M, Hite RK, Fakler B, Jentsch TJ
Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A.
1. Nat Commun - published April 1, 2025
2. Khandelwal NK, Gupta M, Gomez JE, Barkho S, Guan Z, Eng AY, Kawate T, Balasubramani SG, Sali A, Hung DT, Stroud RM
Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection.
1. Cell Rep - published April 1, 2025
2. Perugino CA, Liu H, Feldman J, Marbourg J, Guy TV, Hui A, Ingram N, Liebaert J, Chaudhary N, Tao W, Jacob-Dolan C, Hauser BM, Mian Z, Nathan A, Zhao Z, Kaseke C, Tano-Menka R, Getz MA, Senjobe F, Berrios C, Ofoman O, Manickas-Hill Z, Wesemann DR, Lemieux JE, Goldberg MB, Nündel K, Moormann A, Marshak-Rothstein A, Larocque RC, Ryan ET, Iafrate JA, Lingwood D, Gaiha G, Charles R, Balazs AB, Pandit A, Naranbhai V, Schmidt AG, Pillai S
The network response to Egf is tissue-specific.
1. iScience - published April 1, 2025
2. Awasthi BW, Paulo JA, Burkhart DL, Smith IR, Collins RL, Harper JW, Gygi SP, Haigis KM
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.
1. Sci Adv - published April 1, 2025
2. McKenna MJ, Kraus F, Coelho JPL, Vasandani M, Zhang J, Adams BM, Paulo JA, Harper JW, Shao S
Antitumor activity of vebreltinib and characterization of clinicogenomic features in solid tumors with MET rearrangements.
1. Cancer Discov - published April 1, 2025
2. Nakazawa S, Pecci F, Odintsov I, Gazgalis D, Gottlieb FH, Ricciuti B, Zullo L, Alessi JV, Di Federico A, Aldea M, Garbo E, Gandhi MM, Saini A, Feng WW, Jiang J, Baldacci S, Facchinetti F, Makarem M, Locquet MA, Haratani K, Haradon D, Besse B, Italiano A, Remon J, Lavaud P, Vasseur D, Planchard D, Sato Y, Watanabe Y, Owen S, Cortot AB, Mahran H, Forster MD, Niu J, Tomasini P, Swan Swan L, Tay K, Esteban E, Minchom A, Kizilbash SH, Cruz-Correa M, Yu KP, Zhang X, Chen P, Sangem M, Che J, Sholl LM, Janne PA, Awad MM
Roquin exhibits opposing effects on RNA stem-loop stability through its two ROQ domain binding sites.
1. Proc Natl Acad Sci U S A - published April 1, 2025
2. Tants JN, Walbrun A, Kollwitz L, Friedrich K, Rief M, Schlundt A
MprF from Pseudomonas aeruginosa is a promiscuous lipid scramblase with broad substrate specificity.
1. Sci Adv - published April 1, 2025
2. Hankins MTK, Parrag M, Garaeva AA, Earp JC, Seeger MA, Stansfeld PJ, Bublitz M
Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair.
1. Nat Commun - published April 1, 2025
2. Genta M, Ferrara G, Capelli R, Rondelli D, Sertic S, Bolognesi M, Rizzi M, Rossi F, Jeruzalmi D, Chaves-Sanjuan A, Miggiano R
Cat1 forms filament networks to degrade NAD(+) during the type III CRISPR-Cas antiviral response.
1. Science - published April 1, 2025
2. Baca CF, Majumder P, Hickling JH, Patel DJ, Marraffini LA
A broadly protective human antibody for GI genogroup noroviruses.
1. Nat Microbiol - published April 1, 2025
2. Rimkute I, Olia AS, Suleiman M, Woods KD, Bylund T, Morano NC, Tully ES, Verardi R, Bao S, Beddall MH, Chaimongkol N, Donaldson MM, Du R, Dulan CNM, Gorman J, Henry AR, Schramm CA, Sosnovtsev SV, Stephens T, Todd JP, Tsybovsky Y, Douek DC, Green KY, Rawi R, Shapiro L, Zhou T, Kwong PD, Roederer M
Species-specific components of the Helicobacter pylori Cag type IV secretion system.
1. Infect Immun - published April 1, 2025
2. Bryant KN, Frick-Cheng AE, Solecki LE, Kroh HK, McDonald WH, Lacy DB, McClain MS, Ohi MD, Cover TL
Toward a deeper understanding of dengue: novel method for quantification and isolation of envelope protein epitope-specific antibodies.
1. mSphere - published April 1, 2025
2. Lay S, Bohaud C, Sorn S, Ken S, Rey FA, Ariën KK, Ly S, Duong V, Barba-Spaeth G, Auerswald H, Cantaert T
Structural insights into RNA-guided RNA editing by the Cas13b-ADAR2 complex.
1. Nat Struct Mol Biol - published April 1, 2025
2. Ishikawa J, Kato K, Kannan S, Okazaki S, Ishiguro S, Yamashita K, Yachie N, Nishizawa T, Zhang F, Nishimasu H
Beyond peptide targeting sequences: machine learning of cellular condensate localization.
1. Cell Res - published April 1, 2025
2. Ditlev JA, Forman-Kay JD
Systematic identification of disease-causing promoter and untranslated region variants in 8040 undiagnosed individuals with rare disease.
1. Genome Med - published April 1, 2025
2. Martin-Geary AC, Blakes AJM, Dawes R, Findlay SD, Lord J, Dong S, Walker S, Talbot-Martin J, Wieder N, D'Souza EN, Fernandes M, Hilton S, Lahiri N, Campbell C, Jenkinson S, DeGoede CGEL, Anderson ER, Candler T, Firth H, Burge CB, Sanders SJ, Ellingford J, Baralle D, Banka S, Whiffin N
Drugit: crowd-sourcing molecular design of non-peptidic VHL binders.
1. Nat Commun - published April 1, 2025
2. Scott T, Smethurst CAP, Westermaier Y, Mayer M, Greb P, Kousek R, Biberger T, Bader G, Jandova Z, Schmalhorst PS, Fuchs JE, Magarkar A, Hoenke C, Gerstberger T, Combs SA, Pape R, Phul S, Kothiwale S, Bergner A, Foldit Players, Waterson AG, Weinstabl H, McConnell DB, Meiler J, Böttcher J, Moretti R
After 75 Years, an Alternative to Edman Degradation: A Mechanistic and Efficiency Study of a Base-Induced Method for N-Terminal Peptide Sequencing.
1. J Am Chem Soc - published April 1, 2025
2. Deol H, Raeisbahrami A, Ngo PHT, Swaminathan J, Papoulas O, Marcotte EM, Anslyn EV
Crystal structure of Isthmin-1 and reassessment of its functional role in pre-adipocyte signaling.
1. Nat Commun - published April 1, 2025
2. Li T, Stayrook SE, Li W, Wang Y, Li H, Zhang J, Liu Y, Klein DE
Author Correction: Structure of the human K(2P)13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.
1. Nat Struct Mol Biol - published April 1, 2025
2. Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL Jr
A nanobody that binds to the backside of the ubiquitin conjugating enzyme Ube2G2 differentially affects interactions with its partner E3 Ligases.
1. Commun Biol - published April 1, 2025
2. Suresh P, Wijne C, Sun ZJ, Becht N, Sahay I, Pishesha N, Ploegh H
Essential lipids enrich membrane-associated condensates to rescue synaptic morpho-functional deficits in a mouse model of autism.
1. Cell Rep - published April 1, 2025
2. Arsenault J, Kong T, Saghian R, Weng OY, Pathak SS, Yang C, Chao OY, Rakhaminov G, Forman-Kay JD, Ditlev JA, Yang YM, Wang LY
Precision oncology and genetic ancestry: The science behind population-based cancer disparities.
1. Cancer Cell - published April 1, 2025
2. Davis MB, Martini R
Author Correction: Combinatorial selective ER-phagy remodels the ER during neurogenesis.
1. Nat Cell Biol - published April 1, 2025
2. Hoyer MJ, Capitanio C, Smith IR, Paoli JC, Bieber A, Jiang Y, Paulo JA, Gonzalez-Lozano MA, Baumeister W, Wilfling F, Schulman BA, Harper JW
Structure and infection dynamics of mycobacteriophage Bxb1.
1. Cell - published April 1, 2025
2. Freeman KG, Mondal S, Macale LS, Podgorski J, White SJ, Silva BH, Ortiz V, Huet A, Perez RJ, Narsico JT, Ho MC, Jacobs-Sera D, Lowary TL, Conway JF, Park D, Hatfull GF
Kinetic implications of IP(6) anion binding on the molecular switch of HIV-1 capsid assembly.
1. Sci Adv - published April 1, 2025
2. Gupta M, Hudait A, Yeager M, Voth GA
A germline ETV6 mutation disrupts hematopoiesis via de novo creation of a nuclear export signal.
1. Sci Adv - published April 1, 2025
2. McConville M, Thomas T, Beckner R, Kroger B, Valadez C, Chook YM, Chung S, Liszczak G
Identification of an Allene Warhead That Selectively Targets a Histidine Residue in the Escherichia coli Oxidoreductase Enzyme DsbA.
1. ACS Med Chem Lett - published April 1, 2025
2. Tasdan Y, Balaji GR, Akhtar N, Ilyichova O, Cunliffe T, Heras B, Strat LL, Murray J, Capuano B, Scanlon MJ, Doak BC
Expanding the cultivable human archaeome: Methanobrevibacter intestini sp. nov. and strain Methanobrevibacter smithii 'GRAZ-2' from human faeces.
1. Int J Syst Evol Microbiol - published April 1, 2025
2. Weinberger V, Mohammadzadeh R, Blohs M, Kalt K, Mahnert A, Moser S, Cecovini M, Mertelj P, Zurabishvili T, Arora B, Wolf J, Shinde T, Madl T, Habisch H, Kolb D, Pernitsch D, Hingerl K, Metcalf W, Moissl-Eichinger C
The position of indole methylation controls the structure, DNA binding and cellular functions of mithramycin SA-Trp analogues.
1. Chembiochem - published April 1, 2025
2. Tsodikov OV, Hou C, Bhosale S, Yasuda K, Yetirajam R, Leggas M, Rohr J
Fibronectin-dependent integrin signaling drives EphA2 expression in vascular smooth muscle cells.
1. Am J Physiol Cell Physiol - published April 1, 2025
2. Pearson-Gallion B, Finney AC, Scott ML, Connelly Z, Alam S, Peretik JM, Ben Dhaou C, Bhuiyan MS, Traylor JG Jr, DeGrado WF, Jo H, Yu X, Rom O, Pattillo CB, Dhanesha N, Yurdagul A Jr, Orr AW
UDP-glucose dehydrogenase variants cause dystroglycanopathy.
1. Ann Clin Transl Neurol - published April 1, 2025
2. Reelfs AM, Stephan CM, Czech TM, Cox MO, Joseph S, Darbro BW, Moore SA, Campbell KP, Mathews KD
Recognition of specific PIP2-subtype composition triggers the allosteric control mechanism for selective membrane targeting of cargo loading and release functions of the intracellular sterol transporter StarD4.
1. J Mol Biol - published April 1, 2025
2. Xie H, Weinstein H
Correction: Ren-Shen-Bu-Qi decoction alleviates exercise fatigue through activating PI3K/AKT/Nrf2 pathway in mice.
1. Chin Med - published April 1, 2025
2. Chen Y, Gao T, Bai J, Zhang W, Zhou Y, Zhao R, Deng Y, Liu X, Huang Z, Wang S, Shen C, Liu S, Guo J
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum.
1. FEBS Lett - published April 1, 2025
2. Karapanagioti F, Obermaier S, Slotboom DJ, Poolman B
An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element.
1. Sci Adv - published April 1, 2025
2. Jia H, Liu S, Rao G, Liu Q, Wu J, Cao S, Gong P
Engineering bacteriophages through deep mining of metagenomic motifs.
1. Sci Adv - published April 1, 2025
2. Huss P, Kieft K, Meger A, Nishikawa K, Anantharaman K, Raman S
Itaconate modulates immune responses via inhibition of peroxiredoxin 5.
1. Nat Metab - published April 1, 2025
2. Paulenda T, Echalar B, Potuckova L, Vachova V, Kleverov DA, Mehringer J, Potekhina E, Jacoby A, Sen D, Nelson C, Stegeman R, Sukhov V, Kemper D, Lichti CF, Day NJ, Zhang T, Husarcikova K, Bambouskova M, Fremont DH, Qian WJ, Djuranovic S, Pavlovic-Djuranovic S, Belousov VV, Krezel AM, Artyomov MN
CD36-mediated endocytosis of proteolysis-targeting chimeras.
1. Cell - published April 1, 2025
2. Wang Z, Pan BS, Manne RK, Chen J, Lv D, Wang M, Tran P, Weldemichael T, Yan W, Zhou H, Martinez GM, Shao J, Hsu CC, Hromas R, Zhou D, Qin Z, Lin HK, Li HY
BioStruct-Africa's capacity building workshops as a model for advancing the emerging community of structural biologists in Africa.
1. Commun Chem - published April 1, 2025
2. Sankhe S, Fofana FG, Heiba W, Ogunyemi OM, Masisi K, Muiruri I, Abaah EA, Tepa A, Fru CT, Johnson JT, Tchuenguia CV, Tatchou-Nebangwa NMT, Tsafack DT, Koloko BL, Kulu-Abi TK, Ngounou I, Sovegnon TSD, Kamga RMN, Kouamo MFM, Getahun YC, Moumbock AFA, Cramer KC, Rüffin NV, Djapgne L, Sliz P, Davis J, Fodje MN, Griese JJ, Nji E
The inhibition of PPARα protein degradation alleviates the cardiotoxicity of Tiebangchui by regulating fatty acid metabolism.
1. J Ethnopharmacol - published April 1, 2025
2. Liu X, Yang L, Zhou R, Zhang T, Xu L, Liu Y, Zhang Y, Meng X
Mitochondrial quality control disorder in neurodegenerative disorders: Potential and advantages of traditional Chinese medicines.
1. J Pharm Anal - published April 1, 2025
2. Xu L, Zhang T, Zhu B, Tao H, Liu Y, Liu X, Zhang Y, Meng X
Variant mutation G215C in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation.
1. PLoS Biol - published April 1, 2025
2. Kubinski HC, Despres HW, Johnson BA, Schmidt MM, Jaffrani SA, Turner AH, Fanuele CD, Mills MG, Lokugamage KG, Dumas CM, Shirley DJ, Estes LK, Pekosz A, Crothers JW, Roychoudhury P, Greninger AL, Jerome KR, Di Genova BM, Walker DH, Ballif BA, Ladinsky MS, Bjorkman PJ, Menachery VD, Bruce EA
Newton's cradle-like allosteric mechanism explains regulatory RsmE RNA binding.
1. Res Sq - published April 1, 2025
2. Finol E, Damberger FF, Krepl M, Flügel T, Dietrich P, Michaels TCT, Vögeli B, Šponer J, Allain FH