Member Publications

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134 Member Publications for December 2024

Design and Use of AsLOV2-Based Optogenetic Tools for Actin Imaging.
1. Methods Mol Biol - published December 26, 2024
2. Kroll KL, Sosnick TR, Rock RS
The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responses.
1. Front Immunol - published December 25, 2024
2. Stephens VR, Horner KB, Avila WM, Spicer SK, Chinni R, Bernabe EB, Hinton AO Jr, Damo SM, Eastman AJ, McCallister MM, Osteen KG, Gaddy JA
A goldilocks computational protocol for inhibitor discovery targeting DNA damage responses including replication-repair functions.
1. Front Mol Biosci - published December 13, 2024
2. Moiani D, Tainer JA
A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.
1. Nat Commun - published December 9, 2024
2. Dhamotharan K, Korn SM, Wacker A, Becker MA, Günther S, Schwalbe H, Schlundt A
Chemotherapy induces myeloid-driven spatially confined T cell exhaustion in ovarian cancer.
1. Cancer Cell - published December 9, 2024
2. Launonen IM, Niemiec I, Hincapié-Otero M, Erkan EP, Junquera A, Afenteva D, Falco MM, Liang Z, Salko M, Chamchougia F, Szabo A, Perez-Villatoro F, Li Y, Micoli G, Nagaraj A, Haltia UM, Kahelin E, Oikkonen J, Hynninen J, Virtanen A, Nirmal AJ, Vallius T, Hautaniemi S, Sorger PK, Vähärautio A, Färkkilä A
Automated fibril structure calculations in Xplor-NIH.
1. Structure - published December 9, 2024
2. Barclay AM, Milchberg MH, Warmuth OA, Tuttle MD, Dennis CJ, Schwieters CD, Rienstra CM
Glutamine metabolism Is essential for coronavirus replication in host cells and in mice.
1. J Biol Chem - published December 9, 2024
2. Greene KS, Choi A, Yang N, Chen M, Li R, Qiu Y, Ezzatpour S, Rojas KS, Shen J, Wilson KF, Katt WP, Aguilar HC, Lukey MJ, Whittaker GR, Cerione RA
Molecular features of the serological IgG repertoire elicited by egg-based, cell-based, or recombinant haemagglutinin-based seasonal influenza vaccines: a comparative, prospective, observational cohort study.
1. Lancet Microbe - published December 9, 2024
2. Park J, Bartzoka F, von Beck T, Li ZN, Mishina M, Hebert LS, Kain J, Liu F, Sharma S, Cao W, Eddins DJ, Kumar A, Kim JE, Lee JS, Wang Y, Schwartz EA, Brilot AF, Satterwhite E, Towers DM, McKnight E, Pohl J, Thompson MG, Gaglani M, Dawood FS, Naleway AL, Stevens J, Kennedy RB, Jacob J, Lavinder JJ, Levine MZ, Gangappa S, Ippolito GC, Sambhara S, Georgiou G
Defining a highly conserved B cell epitope in the receptor binding motif of SARS-CoV-2 spike glycoprotein.
1. bioRxiv - published December 9, 2024
2. Malladi SK, Jaiswal D, Ying B, Alsoussi WB, Darling TL, Dadonaite B, Civljak A, Horvath SC, Zhou JQ, Kim W, Turner JS, Schmitz AJ, Han F, Scheaffer SM, Farnsworth CW, Nachbagauer R, Nestorova B, Chalkias S, Klebert MK, Edwards DK, Paris R, Strnad BS, Middleton WD, O'Halloran JA, Presti RM, Bloom JD, Boon ACM, Diamond MS, Bajic G, Ellebedy AH
Direct Monomer Recovery from Ring-Closing Depolymerization of Thermosets.
1. ACS Macro Lett - published December 7, 2024
2. Zheng C, Slor G, Ma Y, Stellacci F
Predictors of HPV vaccination coverage among adolescents in Tennessee during the COVID-19 pandemic: A cross-sectional study.
1. Vaccine - published December 7, 2024
2. Cunningham-Erves J, Sanderson M, Jin SW, Davis J, Brandt HM
Lipid nanosystems for fatty liver therapy and targeted medication delivery a comprehensive review.
1. Int J Pharm - published December 7, 2024
2. Liang C, Liu X, Sun Z, Wen L, Wu J, Shi S, Liu X, Luo N, Li X
Molecular sociology of virus-induced cellular condensates supporting reovirus assembly and replication.
1. Nat Commun - published December 6, 2024
2. Liu X, Xia X, Martynowycz MW, Gonen T, Zhou ZH
Phospholipid Transport Across the Bacterial Periplasm Through the Envelope-spanning Bridge YhdP.
1. J Mol Biol - published December 6, 2024
2. Cooper BF, Clark R, Kudhail A, Dunn D, Tian Q, Bhabha G, Ekiert DC, Khalid S, Isom GL
Identification of an Intrinsically Disordered Region (IDR) in Arginyltransferase 1 (ATE1).
1. Biochemistry - published December 6, 2024
2. Cartwright M, Parakra R, Oduwole A, Zhang F, Deredge DJ, Smith AT
Hederagenin is a Highly Selective Antagonist of the Neuro-peptide FF Receptor 1 that Reveals Mechanisms for Subtype Selectivity.
1. Angew Chem Int Ed Engl - published December 6, 2024
2. Lentschat H, Liessmann F, Tydings C, Schermeng T, Stichel J, Urban N, Schaefer M, Meiler J, Beck-Sickinger AG
Discovery of BBO-8520, a first-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C.
1. Cancer Discov - published December 6, 2024
2. Maciag AE, Stice JP, Wang B, Sharma AK, Chan AH, Lin K, Singh D, Dyba M, Yang Y, Setoodeh S, Smith BP, Ju JH, Jeknic S, Rabara D, Zhang Z, Larsen EK, Esposito D, Denson JP, Ranieri M, Meynardie M, Mehdizadeh S, Alexander PA, Abreu Blanco M, Turner DM, Xu R, Lightstone FC, Wong KK, Stephen AG, Wang K, Simanshu DK, Sinkevicius KW, Nissley DV, Wallace E, McCormick F, Beltran PJ
A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis.
1. Sci Immunol - published December 6, 2024
2. Bohnacker S, Henkel FDR, Hartung F, Geerlof A, Riemer S, Prodjinotho UF, Salah EB, Mourão ASD, Bohn S, Teder T, Thomas D, Gurke R, Boeckel C, Ud-Dean M, König AC, Quaranta A, Alessandrini F, Lechner A, Spitzlberger B, Kabat AM, Pearce E, Haeggström JZ, Hauck SM, Wheelock CE, Jakobsson PJ, Sattler M, Voehringer D, Feige MJ, da Costa CP, Bieren JE
Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.
1. Nat Commun - published December 6, 2024
2. Valerie NCK, Sanjiv K, Mortusewicz O, Zhang SM, Alam S, Pires MJ, Stigsdotter H, Rasti A, Langelier MF, Rehling D, Throup A, Purewal-Sidhu O, Desroses M, Onireti J, Wakchaure P, Almlöf I, Boström J, Bevc L, Benzi G, Stenmark P, Pascal JM, Helleday T, Page BDG, Altun M
Eco-friendly antibacterial electrospinning nanofibrous film containing nano-silver green-synthesized by natural glycoprotein for infected wound healing.
1. J Colloid Interface Sci - published December 6, 2024
2. Li X, Pang L, Duan J, Huang N, Chen X, Huang W, Liu Y, Fu C, Zhang C, Tu H, Zeng C, Liu X, Zhang J
Structural mechanisms of PIP(2) activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1.
1. bioRxiv - published December 6, 2024
2. Xue J, Zeng W, John S, Attiq N, Ottolia M, Jiang Y
Kinetic Implications of IP(6) Anion Binding on the Molecular Switch of the HIV-1 Capsid Assembly.
1. bioRxiv - published December 6, 2024
2. Gupta M, Hudait A, Yeager M, Voth GA
Disruption of LEDGF/p75-directed integration derepresses antisense transcription of the HIV-1 genome.
1. bioRxiv - published December 6, 2024
2. Tedbury PR, Mahboubi D, Puray-Chavez M, Shah R, Ukah OB, Wahoski CC, Fadel HJ, Poeschla EM, Gao X, McFadden WM, Gaitanidou M, Kesesidis N, Kirby KA, Vanderford TH, Kvaratskhelia M, Achuthan V, Behrens RT, Engelman AN, Sarafianos SG
β-1,6-Glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall.
1. Elife - published December 5, 2024
2. Bekirian C, Valsecchi I, Bachellier-Bassi S, Scandola C, Guijarro JI, Chauvel M, Mourer T, Gow NAR, Aimanianda VK, d'Enfert C, Fontaine T
Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer.
1. NPJ Vaccines - published December 5, 2024
2. DeLaitsch AT, Keeffe JR, Gristick HB, Lee JA, Ding W, Liu W, Skelly AN, Shaw GM, Hahn BH, Björkman PJ
Structures of KEOPS bound to tRNA reveal functional roles of the kinase Bud32.
1. Nat Commun - published December 5, 2024
2. Ona Chuquimarca SM, Beenstock J, Daou S, Porat J, Keszei AFA, Yin JZ, Beschauner T, Bayfield MA, Mazhab-Jafari MT, Sicheri F
Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function.
1. Nat Commun - published December 4, 2024
2. Kordon SP, Cechova K, Bandekar SJ, Leon K, Dutka P, Siffer G, Kossiakoff AA, Vafabakhsh R, Araç D
Multicamera simultaneous total internal reflection and interference reflection microscopy.
1. J Microsc - published December 4, 2024
2. Spector JO, Chen J, Szczesna E, Roll-Mecak A
Structural basis for Rab6 activation by the Ric1-Rgp1 complex.
1. Nat Commun - published December 4, 2024
2. Feathers JR, Vignogna RC, Fromme JC
Author Correction: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.
1. Nature - published December 4, 2024
2. Blanchard JW, Akay LA, Davila-Velderrain J, von Maydell D, Mathys H, Davidson SM, Effenberger A, Chen CY, Maner-Smith K, Hajjar I, Ortlund EA, Bula M, Agbas E, Ng A, Jiang X, Kahn M, Blanco-Duque C, Lavoie N, Liu L, Reyes R, Lin YT, Ko T, R'Bibo L, Ralvenius WT, Bennett DA, Cam HP, Kellis M, Tsai LH
Identification of a depupylation regulator for an essential enzyme in Mycobacterium tuberculosis.
1. Proc Natl Acad Sci U S A - published December 3, 2024
2. Kahne SC, Yoo JH, Chen J, Nakedi K, Iyer LM, Putzel G, Samhadaneh NM, Pironti A, Aravind L, Ekiert DC, Bhabha G, Rhee KY, Darwin KH
Channel Gating in a Post-Translational Protein Translocase.
1. Biochemistry - published December 3, 2024
2. Shan SO
Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent "Type V" Kinase Inhibitors.
1. J Med Chem - published December 3, 2024
2. Wittlinger F, Chitnis SP, Pham CD, Damghani T, Patel KB, Möllers M, Schaeffner IK, Abidakun OA, Deng MQ, Ogboo BC, Rasch A, Beyett TS, Buckley B, Feru F, Shaurova T, Knappe C, Eck MJ, Hershberger PA, Scott DA, Brandt AL, Laufer SA, Heppner DE
Yatakemycin biosynthesis requires two deoxyribonucleases for toxin self-resistance.
1. RSC Chem Biol - published December 3, 2024
2. Dorival J, Yuan H, Walker AS, Tang GL, Eichman BF
Bacteroides expand the functional versatility of a conserved transcription factor and transcribed DNA to program capsule diversity.
1. Nat Commun - published December 3, 2024
2. Saba J, Flores K, Marshall B, Engstrom MD, Peng Y, Garje AS, Comstock LE, Landick R
An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode.
1. Nat Commun - published December 3, 2024
2. Jia X, Jing X, Li M, Gao M, Zhong Y, Li E, Liu Y, Li R, Yao G, Liu Q, Zhou M, Hou Y, An L, Hong Y, Li S, Zhang J, Wang W, Zhang K, Gong P, Chiu S
Communication between DNA polymerases and Replication Protein A within the archaeal replisome.
1. Nat Commun - published December 3, 2024
2. Martínez-Carranza M, Vialle L, Madru C, Cordier F, Tekpinar AD, Haouz A, Legrand P, Le Meur RA, England P, Dulermo R, Guijarro JI, Henneke G, Sauguet L
Functional anatomy of zinc finger antiviral protein complexes.
1. Nat Commun - published December 3, 2024
2. Bohn JA, Meagher JL, Takata MA, Gonçalves-Carneiro D, Yeoh ZC, Ohi MD, Smith JL, Bieniasz PD
DNA end sensing and cleavage by the Shedu anti-phage defense system.
1. Cell - published December 3, 2024
2. Loeff L, Walter A, Rosalen GT, Jinek M
Advances in protein structure prediction highlight unexpected commonalities between Gram-positive and Gram-negative conjugative T4SSs.
1. J Mol Biol - published December 3, 2024
2. Breidenstein A, Svedberg D, Ter Beek J, Berntsson RP
Octahedral small virus-like particles of dengue virus type 2.
1. J Virol - published December 3, 2024
2. Johnson A, Dodes Traian M, Walsh RM Jr, Jenni S, Harrison SC
MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi.
1. PLoS Pathog - published December 3, 2024
2. Raghunandanan S, Zhang K, Zhang Y, Priya R, Sze CW, Lou Y, Lynch MJ, Crane BR, Kaplan MH, Li C, Yang XF
A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense.
1. bioRxiv - published December 3, 2024
2. Chang RB, Toyoda HC, Hobbs SJ, Richmond-Buccola D, Wein T, Burger N, Chouchani ET, Sorek R, Kranzusch PJ
Donor Strand Complementation and Calcium Ion Coordination Drive the Chaperone-free Polymerization of Archaeal Cannulae.
1. bioRxiv - published December 3, 2024
2. Sleutel M, Sonani RR, Miller JG, Wang F, Socorro AG, Chen Y, Martin R, Demeler B, Rudolph MJ, Alva V, Remaut H, Egelman EH, Conticello VP
Suppression of melanoma by mice lacking MHC-II: Mechanisms and implications for cancer immunotherapy.
1. J Exp Med - published December 2, 2024
2. Shi H, Medler D, Wang J, Browning R, Liu A, Schneider S, Duran Bojorquez C, Kumar A, Li X, Quan J, Ludwig S, Moresco JJ, Xing C, Moresco EMY, Beutler B
Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis.
1. J Exp Med - published December 2, 2024
2. Ghasempour S, Warner N, Guan R, Rodari MM, Ivanochko D, Whittaker Hawkins R, Marwaha A, Nowak JK, Liang Y, Mulder DJ, Stallard L, Li M, Yu DD, Pluthero FG, Batura V, Zhao M, Siddiqui I, Upton JEM, Hulst JM, Kahr WHA, Mendoza-Londono R, Charbit-Henrion F, Hoefsloot LH, Khiat A, Moreira D, Trindade E, Espinheira MDC, Pinto Pais I, Weerts MJA, Douben H, Kotlarz D, Snapper SB, Klein C, Dowling JJ, Julien JP, Joosten M, Cerf-Bensussan N, Freeman SA, Parlato M, van Ham TJ, Muise AM
Structural evolution of nitrogenase states under alkaline turnover.
1. Nat Commun - published December 2, 2024
2. Warmack RA, Rees DC
Patterns of breast cancer locoregional relapse, metastasis, and subtypes in Ghana.
1. BMC Cancer - published December 2, 2024
2. Boaitey GA, Martini R, Stonaker B, Bonsu EO, Adjei E, Kyei I, Ansah MB, Newman L, Obirikorang C, Davis MB, Fondjo LA
Hospital-wide access to genomic data advanced pediatric rare disease research and clinical outcomes.
1. NPJ Genom Med - published December 2, 2024
2. French CE, Andrews NC, Beggs AH, Boone PM, Brownstein CA, Chopra M, Chou J, Chung WK, D'Gama AM, Doan RN, Ebrahimi-Fakhari D, Goldstein RD, Irons M, Jacobsen C, Kenna M, Lee T, Madden JA, Majmundar AJ, Mann N, Morton SU, Poduri A, Randolph AG, Roberts AE, Roberts S, Sampson MG, Shao DD, Shao W, Sharma A, Shearer E, Shimamura A, Snapper SB, Srivastava S, Thiagarajah JR, Whitman MC, Wojcik MH, Rockowitz S, Sliz P
EF-P and its paralog EfpL (YeiP) differentially control translation of proline-containing sequences.
1. Nat Commun - published December 2, 2024
2. Sieber A, Parr M, von Ehr J, Dhamotharan K, Kielkowski P, Brewer T, Schäpers A, Krafczyk R, Qi F, Schlundt A, Frishman D, Lassak J
De novo variants in LRRC8C resulting in constitutive channel activation cause a human multisystem disorder.
1. EMBO J - published December 2, 2024
2. Quinodoz M, Rutz S, Peter V, Garavelli L, Innes AM, Lehmann EF, Kellenberger S, Peng Z, Barone A, Campos-Xavier B, Unger S, Rivolta C, Dutzler R, Superti-Furga A
Methods to Study Poxvirus Structures by Cryo-EM Imaging Modalities.
1. Methods Mol Biol - published December 2, 2024
2. Hyun J, Hsieh LT, Ayala R, Chang W, Wolf M
Endo-IP and lyso-IP toolkit for endolysosomal profiling of human-induced neurons.
1. Proc Natl Acad Sci U S A - published December 2, 2024
2. Hundley FV, Gonzalez-Lozano MA, Gottschalk LM, Cook ANK, Zhang J, Paulo JA, Harper JW
Bacterial suppressor-of-copper-sensitivity proteins exhibit diverse thiol-disulfide oxidoreductase cellular functions.
1. iScience - published December 2, 2024
2. Hong Y, Qin J, Mitchell L, Paxman JJ, Heras B, Totsika M
Biofilm formation by Staphylococcus aureus is triggered by a drop in the levels of a cyclic dinucleotide.
1. Proc Natl Acad Sci U S A - published December 2, 2024
2. Syed AK, Baral R, Van Vlack ER, Gil-Marqués ML, Lenhart T, Hooper DC, Kahne D, Losick R, Bradshaw N
Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography.
1. bioRxiv - published December 2, 2024
2. Zhou H, Hutchings J, Shiozaki M, Zhao X, Doolittle LK, Yang S, Yan R, Jean N, Riggi M, Yu Z, Villa E, Rosen MK
A minimal complex of KHNYN and zinc-finger antiviral protein binds and degrades single-stranded RNA.
1. Proc Natl Acad Sci U S A - published December 2, 2024
2. Yeoh ZC, Meagher JL, Kang CY, Bieniasz PD, Smith JL, Ohi MD
The three-dimensional genome drives the evolution of asymmetric gene duplicates via enhancer capture-divergence.
1. Sci Adv - published December 2, 2024
2. Lee U, Arsala D, Xia S, Li C, Ali M, Svetec N, Langer CB, Sobreira DR, Eres I, Sosa D, Chen J, Zhang L, Reilly P, Guzzetta A, Emerson JJ, Andolfatto P, Zhou Q, Zhao L, Long M
The nucleocapsid architecture and structural atlas of the prototype baculovirus define the hallmarks of a new viral realm.
1. Sci Adv - published December 2, 2024
2. Johnstone BA, Hardy JM, Ha J, Butkovic A, Koszalka P, Accurso C, Venugopal H, de Marco A, Krupovic M, Coulibaly F
CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples.
1. Elife - published December 2, 2024
2. Elferich J, Kong L, Zottig X, Grigorieff N
Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14.
1. Sci Adv - published December 2, 2024
2. Zhang C, Scott RL, Tunes L, Hsieh MH, Wang P, Kumar A, Khadgi BB, Yang YY, Doxtader Lacy KA, Herrell E, Zhang X, Evers B, Wang Y, Xing C, Zhu H, Nam Y
Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma.
1. Cancer Discov - published December 2, 2024
2. Kader T, Lin JR, Hug CB, Coy S, Chen YA, de Bruijn I, Shih N, Jung E, Pelletier RJ, Lopez Leon M, Mingo G, Omran DK, Lee JS, Yapp C, Satravada BA, Kundra R, Xu Y, Chan S, Tefft JB, Muhlich JL, Kim SH, Gysler SM, Agudo J, Heath JR, Schultz N, Drescher CW, Sorger PK, Drapkin R, Santagata S
Comprehensive microcrystal electron diffraction sample preparation for cryo-EM.
1. Nat Protoc - published December 2, 2024
2. Nicolas WJ, Gillman C, Weaver SJ, Clabbers MTB, Shiriaeva A, Her AS, Martynowycz MW, Gonen T
WD repeat domain 5 (WDR5) inhibitors: a patent review (2016-present).
1. Expert Opin Ther Pat - published December 2, 2024
2. Coker JA, Stauffer SR
Creativity gain or drain: The dual association between boundary-spanning and creativity.
1. Acta Psychol (Amst) - published December 2, 2024
2. Tang M, Liu X, Walsh GS, Gruda D
CryoSamba: Self-supervised deep volumetric denoising for cryo-electron tomography data.
1. J Struct Biol - published December 2, 2024
2. Costa-Filho JI, Theveny L, de Sautu M, Kirchhausen T
A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose.
1. NPJ Vaccines - published December 2, 2024
2. Rostad CA, Yildirim I, Kao C, Yi J, Kamidani S, Peters E, Stephens K, Gibson T, Hsiao HM, Singh K, Spearman P, McCracken C, Agbakoba V, Tomashek KM, Goll JB, Gelber CE, Johnson RA, Lee S, Maner-Smith K, Bosinger S, Ortlund EA, Chen X, Anderson LJ, Wrammert J, Suthar M, Rouphael N, Anderson EJ
Discovery of Nanosota-EB1 and -EB2 as Novel Nanobody Inhibitors Against Ebola Virus Infection.
1. PLoS Pathog - published December 2, 2024
2. Bu F, Ye G, Morsheimer K, Mendoza A, Turner-Hubbard H, Herbst M, Spiller B, Wadzinski BE, Eaton B, Anantpadma M, Yang G, Liu B, Davey R, Li F
Virus adaptation to heparan sulfate comes with capsid stability tradeoff.
1. Elife - published December 2, 2024
2. Tee HK, Crouzet S, Muliyil A, Mathez G, Cagno V, Dal Peraro M, Antanasijevic A, Clément S, Tapparel C
Neoantigen-Displaying Protein Nanoparticles as a Therapeutic Cancer Vaccine Against Melanoma.
1. Adv Healthc Mater - published December 2, 2024
2. Kim Y, Lee S, Yoon J, Shin Y, Kang S, Kim SY, Woo S, Song JJ, Jon S
MolecularWebXR: Multiuser discussions in chemistry and biology through immersive and inclusive augmented and virtual reality.
1. J Mol Graph Model - published December 2, 2024
2. Cortés Rodríguez FJ, Frattini G, Phloi-Montri S, Pinto Meireles FT, Terrien DA, Cruz-León S, Dal Peraro M, Schier E, Lindorff-Larsen K, Limpanuparb T, Moreno DM, Abriata LA
Disruption of deoxyribonucleotide triphosphate biosynthesis leads to RAS proto-oncogene activation and perturbation of mitochondrial metabolism.
1. J Biol Chem - published December 2, 2024
2. Suspène R, Raymond KA, Guardado-Calvo P, Dairou J, Bonhomme F, Bonenfant C, Guyetant S, Lecomte T, Pagès JC, Vartanian JP
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.
1. Elife - published December 2, 2024
2. Joseph RE, Wales TE, Jayne S, Britton RG, Fulton DB, Engen JR, Dyer MJS, Andreotti AH
PTEN loss in glioma cell lines leads to increased extracellular vesicle biogenesis and PD-L1 cargo in a PI3K-dependent manner.
1. J Biol Chem - published December 2, 2024
2. Sanchez JC, Pierpont TM, Argueta-Zamora D, Wilson K, August A, Cerione RA
Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains.
1. Mol Cell - published December 2, 2024
2. Gu Y, Li H, Deep A, Enustun E, Zhang D, Corbett KD
The human zinc-binding cysteine proteome.
1. Cell - published December 2, 2024
2. Burger N, Mittenbühler MJ, Xiao H, Shin S, Wei SM, Henze EK, Schindler S, Mehravar S, Wood DM, Petrocelli JJ, Sun Y, Sprenger HG, Latorre-Muro P, Smythers AL, Bozi LHM, Darabedian N, Zhu Y, Seo HS, Dhe-Paganon S, Che J, Chouchani ET
Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase.
1. bioRxiv - published December 2, 2024
2. Baytshtok V, DiMattia MA, Lima CD
Microcomputed Tomography for the Microstructure Evaluation of 3D Bioprinted Scaffolds.
1. ACS Appl Bio Mater - published December 1, 2024
2. Ramirez SP, Hernandez I, Balcorta HV, Kumar P, Kumar V, Poon W, Joddar B
A lineage-specific protein network at the trypanosome nuclear envelope.
1. Nucleus - published December 1, 2024
2. Butterfield ER, Obado SO, Scutts SR, Zhang W, Chait BT, Rout MP, Field MC
MicroED structure of the C11 cysteine protease clostripain.
1. J Struct Biol X - published December 1, 2024
2. Ruma YN, Bu G, Hattne J, Gonen T
G-PLIP: Knowledge graph neural network for structure-free protein-ligand bioactivity prediction.
1. Comput Struct Biotechnol J - published December 1, 2024
2. Crouzet SJ, Lieberherr AM, Atz K, Nilsson T, Sach-Peltason L, Müller AT, Dal Peraro M, Zhang JD
Diverse roles of Primary Health Care in COVID-19 vaccination across 28 European countries - Insights from the Eurodata study.
1. Eur J Gen Pract - published December 1, 2024
2. Guisado-Clavero M, Gómez-Bravo R, Gefaell Larrondo I, Ramos Del Rio L, Fitzgerald L, Vinker S, Vaes B, Tsigarovski G, Torzsa P, Ticmane G, Sentker T, Serafini A, Sattler M, Streit S, Petricek G, Petrazzuoli F, Petek D, Perjés Á, Penakacherla N, Senn O, Neves AL, Nessler K, Murauskienė L, Mossong J, Kozlovska L, Segernäs A, Krztoń-Królewiecka A, Kostić M, Kırkoç Üçüncü E, Çimen Korkmaz B, Knežević S, Jandrić-Kočić M, Kastbom L, Shushman I, Ilkov O, Hoffmann K, Heleno B, Hanževački M, Gjorgjievski D, Feldman S, Domeyer PR, Delphin Peña M, Ćosić Divjak A, Busneag IC, Brutskaya-Stempkovskaya E, Bensemmane S, Bayen S, Bakola M, Adler L, Assenova R, Ares-Blanco S, Astier-Peña MP, Lingner H
Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies.
1. Comput Struct Biotechnol J - published December 1, 2024
2. Fouillen A, Couvineau P, Gaibelet G, Riché S, Orcel H, Mendre C, Kanso A, Lanotte R, Nguyen J, Dimon J, Urbach S, Sounier R, Granier S, Bonnet D, Cong X, Mouillac B, Déméné H
On the function of TRAP substrate-binding proteins: the isethionate-specific binding protein IseP.
1. Biochem J - published December 1, 2024
2. Newton-Vesty MC, Currie MJ, Davies JS, Panjikar S, Sethi A, Whitten AE, Tillett ZD, Wood DM, Wright JD, Love MJ, Allison TM, Jamieson SA, Mace PD, North RA, Dobson RCJ
Molecular investigation of harmful cyanobacteria reveals hidden risks and niche partitioning in Kenyan Lakes.
1. Harmful Algae - published December 1, 2024
2. Zepernick BN, Hart LN, Chase EE, Natwora KE, Obuya JA, Olokotum M, Houghton KA, Kiledal EA, NSF-IRES 2022 Lake Victoria Research Consortium, Sheik CS, Sherman DH, Dick GJ, Wilhelm SW, Sitoki L, Otiso KM, McKay RML, Bullerjahn GS
Development of Broad-Spectrum β-Cyclodextrins-Based Nanomaterials Against Influenza Viruses.
1. J Med Virol - published December 1, 2024
2. Zwygart AC, Medaglia C, Zhu Y, Bart Tarbet E, Jonna W, Fage C, Le Roy D, Roger T, Clément S, Constant S, Huang S, Stellacci F, Silva PJ, Tapparel C
TOMOMAN: a software package for large-scale cryo-electron tomography data preprocessing, community data sharing and collaborative computing.
1. J Appl Crystallogr - published December 1, 2024
2. Khavnekar S, Erdmann PS, Wan W
HIV-1-envelope trimer transitions from prefusion-closed to CD4-bound-open conformations through an occluded-intermediate state.
1. Comput Struct Biotechnol J - published December 1, 2024
2. Lee M, Lu M, Zhang B, Zhou T, Katte R, Han Y, Rawi R, Kwong PD
HyperMPNN-A general strategy to design thermostable proteins learned from hyperthermophiles.
1. bioRxiv - published December 1, 2024
2. Ertelt M, Schlegel P, Beining M, Kaysser L, Meiler J, Schoeder CT
Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C-MHC I complex Demonstrates the Antitumor Efficacy of Hapten-Based Strategies.
1. Cancer Res - published December 1, 2024
2. Pandey A, Rohweder PJ, Chan LM, Ongpipattanakul C, Chung DH, Paolella B, Quimby FM, Nguyen N, Verba KA, Evans MJ, Craik CS
Rational design yields RNA-binding zinc finger domains with altered sequence specificity.
1. RNA - published December 1, 2024
2. Liang Q, Xiang J, Yeo GW, Corbett KD
Efn1 and Efn2 are extracellular 5'-nucleotidases induced during the fission yeast response to phosphate starvation.
1. mBio - published December 1, 2024
2. Innokentev A, Sanchez AM, Monetti M, Schwer B, Shuman S
Structure and assembly of the dystrophin glycoprotein complex.
1. Nature - published December 1, 2024
2. Wan L, Ge X, Xu Q, Huang G, Yang T, Campbell KP, Yan Z, Wu J
Cryo-EM structure of Nipah virus RNA polymerase complex.
1. Sci Adv - published December 1, 2024
2. Wang Y, Zhao L, Zhang Y, Wang Y, Tang J, Liu S, Gao H, Zhang X, Zinzula L, Kornberg RD, Zhang H
SRC kinase drives multidrug resistance induced by KRAS-G12C inhibition.
1. Sci Adv - published December 1, 2024
2. Song X, Zhou Z, Elmezayen A, Wu R, Yu C, Gao B, Minna JD, Westover KD, Zeh HJ, Kroemer G, Heasley LE, Kang R, Tang D
Structure of apolipoprotein B100 bound to the low-density lipoprotein receptor.
1. Nature - published December 1, 2024
2. Reimund M, Dearborn AD, Graziano G, Lei H, Ciancone AM, Kumar A, Holewinski R, Neufeld EB, O'Reilly FJ, Remaley AT, Marcotrigiano J
Discovery and engineering of the antibody response to a prominent skin commensal.
1. Nature - published December 1, 2024
2. Bousbaine D, Bauman KD, Chen YE, Lalgudi PV, Nguyen TTD, Swenson JM, Yu VK, Tsang E, Conlan S, Li DB, Jbara A, Zhao A, Naziripour A, Veinbachs A, Lee YE, Phung JL, Dimas A, Jain S, Meng X, Pham TPT, McLaughlin MI, Barkal LJ, Gribonika I, Van Rompay KKA, Kong HH, Segre JA, Belkaid Y, Barnes CO, Fischbach MA
Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity.
1. PLoS Genet - published December 1, 2024
2. Dai Q, Preusse K, Yu D, Kovall RA, Thorner K, Lin X, Kopan R
The C-terminal activating domain promotes pannexin 1 channel opening.
1. Proc Natl Acad Sci U S A - published December 1, 2024
2. Henze E, Ehrlich JJ, Robertson JL, Gelsleichter E, Kawate T
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells.
1. Cell Stem Cell - published December 1, 2024
2. Zeng J, Nguyen MA, Liu P, da Silva LF, Levesque S, Lin LY, Justus DG, Petri K, Clement K, Porter SN, Verma A, Neri NR, Rosanwo T, Ciuculescu MF, Abriss D, Mintzer E, Maitland SA, Demirci S, Cha HJ, Orkin SH, Tisdale JF, Williams DA, Zhu LJ, Pruett-Miller SM, Pinello L, Joung JK, Pattanayak V, Manis JP, Armant M, Pellin D, Brendel C, Wolfe SA, Bauer DE
A general system for targeting MHC class II-antigen complex via a single adaptable loop.
1. Nat Biotechnol - published December 1, 2024
2. Du H, Liu J, Jude KM, Yang X, Li Y, Bell B, Yang H, Kassardjian A, Blackson W, Mobedi A, Parekh U, Parra Sperberg RA, Julien JP, Mellins ED, Garcia KC, Huang PS
OXA β-lactamases from Acinetobacter spp. are membrane bound and secreted into outer membrane vesicles.
1. mBio - published December 1, 2024
2. Capodimonte L, Meireles FTP, Bahr G, Bonomo RA, Dal Peraro M, López C, Vila AJ
Epitope mapping via in vitro deep mutational scanning methods and its applications.
1. J Biol Chem - published December 1, 2024
2. Keen MM, Keith AD, Ortlund EA
An amino acid-resolution interactome for motile cilia identifies the structure and function of ciliopathy protein complexes.
1. Dev Cell - published December 1, 2024
2. McCafferty CL, Papoulas O, Lee C, Bui KH, Taylor DW, Marcotte EM, Wallingford JB
Influenza a virus antiparallel helical nucleocapsid-like pseudo-atomic structure.
1. Nucleic Acids Res - published December 1, 2024
2. Chenavier F, Zarkadas E, Freslon LL, Stelfox AJ, Schoehn G, Ruigrok RWH, Ballandras-Colas A, Crépin T
Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analogue.
1. J Biol Chem - published December 1, 2024
2. Weinberg J, Liu KH, Lee CM, Crandall WJ, Cuevas AR, Druzak SA, Morgan ET, Jarrell ZR, Ortlund EA, Martin GS, Singer G, Strobel FH, Go YM, Jones DP
Redirecting E3 Ubiquitin Ligases for Targeted Protein Degradation with Heterologous Recognition Domains.
1. J Biol Chem - published December 1, 2024
2. Yang H, Zheng G, Li GY, Alshaye A, Orkin SH
Abo1 ATPase facilitates the dissociation of FACT from chromatin.
1. Nucleic Acids Res - published December 1, 2024
2. Jang J, Kang Y, Zofall M, Woo S, An S, Cho C, Grewal S, Lee JY, Song JJ
Discovery of the Cytocapsular Membrane as Hallmark of Malignant Tumors.
1. Biochemistry - published December 1, 2024
2. Yi T, Wagner G
Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture.
1. PNAS Nexus - published December 1, 2024
2. Kono Y, Pack CG, Ichikawa T, Komatsubara A, Adam SA, Miyazawa K, Rolas L, Nourshargh S, Medalia O, Goldman RD, Fukuma T, Kimura H, Shimi T
Characterization of intact FeoB in a lipid bilayer using styrene-maleic acid (SMA) copolymers.
1. Biochim Biophys Acta Biomembr - published December 1, 2024
2. Lee M, Armstrong CM, Smith AT
Conformational Regulation of Vertebrate γ-Tubulin Ring Complexes by CM1 Proteins.
1. Cytoskeleton (Hoboken) - published December 1, 2024
2. Wieczorek M
DARPins as a novel tool to detect and degrade p73.
1. Cell Death Dis - published December 1, 2024
2. Münick P, Zielinski J, Strubel A, Gutfreund N, Dreier B, Schaefer JV, Schäfer B, Gebel J, Osterburg C, Chaikuad A, Knapp S, Plückthun A, Dötsch V
Automatic detection of alignment errors in cryo-electron tomography.
1. J Struct Biol - published December 1, 2024
2. de Isidro-Gómez FP, Vilas JL, Carazo JM, Sorzano COS
A global product of 150-m urban building height based on spaceborne lidar.
1. Sci Data - published December 1, 2024
2. Ma X, Zheng G, Xu C, Moskal LM, Gong P, Guo Q, Huang H, Li X, Liang X, Pang Y, Wang C, Xie H, Yu B, Zhao B, Zhou Y
Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes.
1. Cell - published December 1, 2024
2. McFadden E, Monticelli SR, Wang A, Ramamohan AR, Batchelor TG, Kuehne AI, Bakken RR, Tse AL, Chandran K, Herbert AS, McLellan JS
The nitrogenase mechanism: new roles for the dangler?
1. J Biol Inorg Chem - published December 1, 2024
2. Warmack RA, Rees DC
The alphavirus determinants of intercellular long extension formation.
1. mBio - published December 1, 2024
2. Martin CK, Wan JJ, Yin P, Morrison TE, Messer WB, Rivera-Amill V, Lai JR, Grau N, Rey FA, Couderc T, Lecuit M, Kielian M
Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors.
1. ACS Pharmacol Transl Sci - published December 1, 2024
2. Tarullo M, Fernandez Rodriguez G, Iaiza A, Venezia S, Macone A, Incocciati A, Masciarelli S, Marchioni M, Giorgis M, Lolli ML, Fornaseri F, Proietti L, Grebien F, Rosignoli S, Paiardini A, Rotili D, Mai A, Bochenkova E, Caflisch A, Fazi F, Fatica A
Unveiling the versatility of the thioredoxin framework: Insights from the structural examination of Francisella tularensis DsbA1.
1. Comput Struct Biotechnol J - published December 1, 2024
2. Penning S, Hong Y, Cunliffe T, Hor L, Totsika M, Paxman JJ, Heras B
Affinity maturation of antibody responses is mediated by differential plasma cell proliferation.
1. Science - published December 1, 2024
2. MacLean AJ, Deimel LP, Zhou P, ElTanbouly MA, Merkenschlager J, Ramos V, Santos GS, Hägglöf T, Mayer CT, Hernandez B, Gazumyan A, Nussenzweig MC
Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen.
1. NPJ Vaccines - published December 1, 2024
2. Verhoeven D, Sponseller BA, Crowe JE Jr, Bangaru S, Webby RJ, Lee BM
The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A.
1. Cell Rep - published December 1, 2024
2. Kochen Rossi J, Nuevo-Tapioles C, O'Keefe RA, Hunkeler M, Schmoker AM, Fissore-O'Leary M, Su W, Ahearn IM, Branco C, Cheong H, Esposito D, Clotea I, Ueberheide B, Fischer ES, Philips MR
Inositol phosphates dynamically enhance stability, solubility and catalytic activity of mTOR.
1. J Biol Chem - published December 1, 2024
2. Rameh LE, York JD, Blind RD
Periodic ER-plasma membrane junctions support long-range Ca(2+) signal integration in dendrites.
1. Cell - published December 1, 2024
2. Benedetti L, Fan R, Weigel AV, Moore AS, Houlihan PR, Kittisopikul M, Park G, Petruncio A, Hubbard PM, Pang S, Xu CS, Hess HF, Saalfeld S, Rangaraju V, Clapham DE, De Camilli P, Ryan TA, Lippincott-Schwartz J
Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM.
1. Structure - published December 1, 2024
2. Iyer KA, Kobayashi T, Murayama T, Samsó M
Chlorophyllase from Arabidopsis thaliana Reveals an Emerging Model for Controlling Chlorophyll Hydrolysis.
1. ACS Bio Med Chem Au - published December 1, 2024
2. Knapp M, Jo M, Henthorn CL, Brimberry M, Gnann AD, Dowling DP, Bridwell-Rabb J
Trends in Specialty Training and National Institutes of Health Funding Among Surgeon-Scientists.
1. Ann Surg Open - published December 1, 2024
2. Velez G, Mahajan VB, Weigel RJ, Lentz SR
The human RAD52 complex undergoes phase separation and facilitates bundling and end-to-end tethering of RAD51 presynaptic filaments.
1. bioRxiv - published December 1, 2024
2. Alshareedah I, Pangeni S, Dewan PA, Honda M, Liao TW, Spies M, Ha T
Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins.
1. bioRxiv - published December 1, 2024
2. May AJ, Lella M, Lindenberger J, Berkman A, Dutta M, Barr M, Parks R, Newman A, Huang X, Kumar U, Song K, Ilevbare V, Sammour S, Park CS, Adhikari RD, Devkota P, Janowska K, Liu Y, Scapellato G, Spence TN, Mansouri K, Edwards RJ, Haynes BF, Acharya P
Unique structural features in a deep-sea CYP51 relate to high pressure adaptation.
1. Res Sq - published December 1, 2024
2. Hargrove TY, Lamb DC, Wawrzak Z, Minasov G, Goldstone JV, Kelly SL, Stegeman J, Lepesheva GI
Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI.
1. bioRxiv - published December 1, 2024
2. Lopatto EDB, Santiago-Borges JM, Sanick DA, Malladi SK, Azimzadeh PN, Timm MW, Fox IF, Schmitz AJ, Turner JS, Ahmed SS, Ortinau L, Gualberto NC, Pinkner JS, Dodson KW, Ellebedy AH, Kau AL, Hultgren SJ
Fe starvation induces a second LHCI tetramer to photosystem I in green algae.
1. bioRxiv - published December 1, 2024
2. Liu HW, Khera R, Grob P, Gallaher SD, Purvine SO, Nicora CD, Lipton MS, Niyogi KK, Nogales E, Iwai M, Merchant SS
Bioinformatics identification based on causal association inference using multi-omics reveals the underlying mechanism of Gui-Zhi-Shao-Yao-Zhi-Mu decoction in modulating rheumatoid arthritis.
1. Phytomedicine - published December 1, 2024
2. Yang J, Yang H, Wang F, Dai Y, Deng Y, Shi K, Zhu Z, Liu X, Ma X, Gao Y