Member Publications

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120 Member Publications for November 2024

Protein Secondary Structure and DNA/RNA Detection for Cryo-EM and Cryo-ET Using Emap2sec and Emap2sec().
1. Methods Mol Biol - published November 22, 2024
2. Baghirov J, Zhu H, Wang X, Kihara D
Combining external physical stimuli and nanostructured materials for upregulating pro-regenerative cellular pathways in peripheral nerve repair.
1. Front Cell Dev Biol - published November 21, 2024
2. Redolfi Riva E, Özkan M, Stellacci F, Micera S
Discovery of selective Orai channel blockers bearing an indazole or a pyrazole scaffold.
1. Eur J Med Chem - published November 15, 2024
2. Liardo E, Pham AT, Ghilardi AF, Zhelay T, Szteyn K, Gandi NL, Ekkati A, Koerner S, Kozak JA, Sun L
Secondary Structure Detection and Structure Modeling for Cryo-EM.
1. Methods Mol Biol - published November 14, 2024
2. Punuru P, Jain A, Kihara D
Engineered bispecific antibodies with enhanced breadth and potency against SARS-CoV-2 variants and SARS-related coronaviruses.
1. Med Microbiol Immunol - published November 9, 2024
2. Chang F, Wu Q, Hu Y, Pan Z, Liu YC, Li YZ, Bostina M, Liu W, Zhao P, Qu X, Li YP
Lamins and chromatin join forces.
1. Adv Biol Regul - published November 9, 2024
2. Wang B, Luo Q, Medalia O
A proteolytic AAA+ machine poised to unfold protein substrates.
1. Nat Commun - published November 8, 2024
2. Ghanbarpour A, Sauer RT, Davis JH
Two dynamic, N-terminal regions are required for function in Ribosomal RNA Adenine Dimethylase family members.
1. RNA - published November 8, 2024
2. McGaha DA, Collins A, Ajisafe LO, Perdigao CC, Bondrowski JL, Fetsch K, Dunkle JA
Author Correction: Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis.
1. Nat Chem Biol - published November 8, 2024
2. Imai Y, Hauk G, Quigley J, Liang L, Son S, Ghiglieri M, Gates MF, Morrissette M, Shahsavari N, Niles S, Baldisseri D, Honrao C, Ma X, Guo JJ, Berger JM, Lewis K
Expanding the Substrate Selectivity of the Fimsbactin Biosynthetic Adenylation Domain, FbsH.
1. ACS Chem Biol - published November 8, 2024
2. Ahmed SF, Balutowski A, Yang J, Wencewicz TA, Gulick AM
Fabrication of core-shell nanostructure via novel ligand-defect reassembly strategy for efficient photocatalytic hydrogen evolution and NO removal.
1. J Colloid Interface Sci - published November 8, 2024
2. Liu X, Wu K, Jia C, He Y, Qiu Y, Fang Y, Ma H, Wang S, Wei S, Dong F
Hope for Others: Research Results from the University of Pittsburgh Rapid Autopsy Program for Breast Cancer.
1. bioRxiv - published November 8, 2024
2. Chang AC, Balic M, Bartholow T, Bhargava R, Brown DD, Brown L, Brufsky A, Cao Y, Carleton N, Clark AM, Cody M, Ding K, Deible C, Elangovan A, Foldi J, Geisler D, Hodgdon C, Howard N, Li Z, Liu JB, Lopez-Nunez O, Mary SJ, McGinn O, Miller L, Mori K, Pecar G, Priedigkeit N, Puhalla S, Rosenzweig MQ, Roy P, Savariau L, Walker S, Waltermire H, Wedn AM, Wells A, Yates ME, Xavier J, Lee AV, Oesterreich S
Protein degradation kinetics measured by microinjection and live-cell fluorescence microscopy.
1. Sci Rep - published November 7, 2024
2. Vukovic D, Winkelvoß D, Kapp JN, Hänny AC, Bürgisser H, Riermeier L, Udovcic A, Tiefenboeck P, Plückthun A
Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
1. J Med Chem - published November 7, 2024
2. Xu R, Zhou H, Bai L, McEachern D, Wu D, Acharyya RK, Wang M, Tošović J, Yang CY, Chinnaswamy K, Meagher JL, Stuckey JA, Liu C, Wang M, Wen B, Sun D, Wang S
Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain.
1. Nat Commun - published November 7, 2024
2. Wu W, Kumar P, Brautigam CA, Tso SC, Baniasadi HR, Kober DL, Gilles-Gonzalez MA
PARP enzyme de novo synthesis of protein-free poly(ADP-ribose).
1. Mol Cell - published November 7, 2024
2. Langelier MF, Mirhasan M, Gilbert K, Sverzhinksy A, Furtos A, Pascal JM
Role of the GRK2/3 N-terminus in discriminating the endocytic effects of opioid agonist drugs.
1. Mol Pharmacol - published November 6, 2024
2. Li J, Inoue A, Manglik A, von Zastrow M
RH5 antigenic landscape shapes vaccine and antibody development.
1. Trends Pharmacol Sci - published November 6, 2024
2. Patel PN, Tolia NH
Targeting adhesion G protein-coupled receptors. Current status and future perspectives.
1. Structure - published November 6, 2024
2. Liessmann F, von Bredow L, Meiler J, Liebscher I
AlphaFold2 enables accurate deorphanization of ligands to single-pass receptors.
1. Cell Syst - published November 6, 2024
2. Banhos Danneskiold-Samsøe N, Kavi D, Jude KM, Nissen SB, Wat LW, Coassolo L, Zhao M, Santana-Oikawa GA, Broido BB, Garcia KC, Svensson KJ
The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling.
1. bioRxiv - published November 6, 2024
2. Jamaluddin A, Wyatt RA, Lee J, Dowsett GKC, Tadross JA, Broichhagen J, Yeo GSH, Levitz J, Gorvin CM
Lrp1 facilitates infection of neurons by Jamestown Canyon virus.
1. bioRxiv - published November 6, 2024
2. Frey ZD, Price DA, Connors KA, Rush RE, Brown G, Sterling CE, Fatma F, Schwarz MM, Ganaie S, Cui X, Wills ZP, Leung DW, Amarasinghe GK, Hartman AL
Biochemical analysis of EGFR exon20 insertion variants insASV and insSVD and their inhibitor sensitivity.
1. Proc Natl Acad Sci U S A - published November 5, 2024
2. Zhao H, Beyett TS, Jiang J, Rana JK, Schaeffner IK, Santana J, Jänne PA, Eck MJ
2.6-Å resolution cryo-EM structure of a class Ia ribonucleotide reductase trapped with mechanism-based inhibitor N(3)CDP.
1. Proc Natl Acad Sci U S A - published November 5, 2024
2. Westmoreland DE, Feliciano PR, Kang G, Cui C, Kim A, Stubbe J, Nocera DG, Drennan CL
Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library.
1. J Am Chem Soc - published November 5, 2024
2. Razumkov H, Jiang Z, Baek K, You I, Geng Q, Donovan KA, Tang MT, Metivier RJ, Mageed N, Seo P, Li Z, Byun WS, Hinshaw SM, Sarott RC, Fischer ES, Gray NS
Ren-Shen-Bu-Qi decoction alleviates exercise fatigue through activating PI3K/AKT/Nrf2 pathway in mice.
1. Chin Med - published November 5, 2024
2. Chen Y, Gao T, Bai J, Zhang W, Zhou Y, Zhao R, Deng Y, Liu X, Huang Z, Wang S, Shen C, Liu S, Guo J
Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination.
1. Cell Rep - published November 5, 2024
2. Clark JJ, Hoxie I, Adelsberg DC, Sapse IA, Andreata-Santos R, Yong JS, Amanat F, Tcheou J, Raskin A, Singh G, González-Domínguez I, Edgar JE, Bournazos S, Sun W, Carreño JM, Simon V, Ellebedy AH, Bajic G, Krammer F
Mechanisms of amphibian arrestin 1 self-association and dynamic distribution in retinal photoreceptors.
1. J Biol Chem - published November 5, 2024
2. Barnes CL, Salom D, Namitz K, Smith WC, Knutson BA, Cosgrove MS, Kiser PD, Calvert PD
Optimizing Transmembrane Protein Assemblies in Nanodiscs for Structural Studies: A Comprehensive Manual.
1. Bio Protoc - published November 5, 2024
2. Vilela F, Sauvanet C, Bezault A, Volkmann N, Hanein D
DISTANT RIBOSE 2'-O-METHYLATION OF 23S rRNA HELIX 69 PRE-ORDERS THE CAPREOMYCIN DRUG BINDING POCKET AT THE RIBOSOME SUBUNIT INTERFACE.
1. bioRxiv - published November 5, 2024
2. Nandi S, Dey D, Srinivas P, Dunham CM, Conn GL
OXA β-lactamases from Acinetobacter spp. are membrane-bound and secreted into outer membrane vesicles.
1. bioRxiv - published November 5, 2024
2. Capodimonte L, Meireles FTP, Bahr G, Bonomo RA, Dal Peraro M, López C, Vila AJ
Structure of the microtubule anchoring factor NEDD1 bound to the γ-tubulin ring complex.
1. bioRxiv - published November 5, 2024
2. Muñoz-Hernández H, Xu Y, Zhang D, Xue A, Aher A, Camardiel AP, Walker E, Marxer F, Kapoor TM, Wieczorek M
Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses.
1. Elife - published November 4, 2024
2. Matsui A, Spangler C, Elferich J, Shiozaki M, Jean N, Zhao X, Qin M, Zhong H, Yu Z, Gouaux E
PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation.
1. EMBO Rep - published November 4, 2024
2. Chin Sang C, Moore G, Tereshchenko M, Zhang H, Nosella ML, Dasovich M, Alderson TR, Leung AKL, Finkelstein IJ, Forman-Kay JD, Lee HO
Determinants in the HTLV-1 capsid major homology region that are critical for virus particle assembly.
1. J Mol Biol - published November 4, 2024
2. Yang H, Arndt WG, Zhang W, Mansky LM
Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies.
1. bioRxiv - published November 4, 2024
2. Perez Almeria CV, Otun O, Schlimgen R, Lamme TD, Crudden C, Youssef N, Musli L, Jenjak S, Bobkov V, Drube J, Hoffmann C, Volkman BF, Granier S, Bechara C, Siderius M, Heukers R, Schafer CT, Smit MJ
Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.
1. Nat Commun - published November 3, 2024
2. Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF
Structural diversity and clustering of bacterial flagellar outer domains.
1. Nat Commun - published November 3, 2024
2. Fields JL, Zhang H, Bellis NF, Petersen HA, Halder SK, Rich-New ST, Krupovic M, Wu H, Wang F
A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores.
1. bioRxiv - published November 3, 2024
2. Stewart MG, Carrier JS, Zahm JA, Harrison SC, Miller MP
Publisher Correction: Massively parallel single-cell sequencing of diverse microbial populations.
1. Nat Methods - published November 3, 2024
2. Lan F, Saba J, Ross TD, Zhou Z, Krauska K, Anantharaman K, Landick R, Venturelli OS
Open-source Electrophilic Fragment Screening Platform to Identify Chemical Starting Points for UCHL1 Covalent Inhibitors.
1. SLAS Discov - published November 3, 2024
2. Ficarro SB, Marto ZH, Girardi NM, Deng D, Maisonet IJ, Adelmant G, Fleming LE, Sharafi M, Tavares I, Zhao A, Kim H, Seo HS, Dhe-Paganon S, Buhrlage SJ, Marto JA
Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection.
1. Nat Commun - published November 2, 2024
2. Young MG, Straub TJ, Worby CJ, Metsky HC, Gnirke A, Bronson RA, van Dijk LR, Desjardins CA, Matranga C, Qu J, Villicana JB, Azimzadeh P, Kau A, Dodson KW, Schreiber HL 4th, Manson AL, Hultgren SJ, Earl AM
FREE FATTY ACIDS INHIBIT AN ION-COUPLED MEMBRANE TRANSPORTER BY DISSIPATING THE ION GRADIENT.
1. J Biol Chem - published November 2, 2024
2. Wang X, Rusinova R, Gregorio GG, Boudker O
Oligomerization of Protein Arginine Methyltransferase 1 and Its Functional Impact on Substrate Arginine Methylation.
1. J Biol Chem - published November 2, 2024
2. Dang T, EswarKumar N, Tripathi SK, Yan C, Wang CH, Cao M, Paul TK, Agboluaje EO, Xiong MP, Ivanov I, Ho MC, Zheng YG
Social state alters vision using three circuit mechanisms in Drosophila.
1. Nature - published November 2, 2024
2. Schretter CE, Hindmarsh Sten T, Klapoetke N, Shao M, Nern A, Dreher M, Bushey D, Robie AA, Taylor AL, Branson K, Otopalik A, Ruta V, Rubin GM
Predicting multiple conformations of ligand binding sites in proteins suggests that AlphaFold2 may remember too much.
1. Proc Natl Acad Sci U S A - published November 2, 2024
2. Lazou M, Khan O, Nguyen T, Padhorny D, Kozakov D, Joseph-McCarthy D, Vajda S
Design principles for accurate folding of DNA origami.
1. Proc Natl Acad Sci U S A - published November 2, 2024
2. Aksel T, J Navarro E, Fong N, Douglas SM
Na(+)-V-ATPase inhibitor curbs VRE growth and unveils Na(+) pathway structure.
1. Nat Struct Mol Biol - published November 2, 2024
2. Suzuki K, Goto Y, Otomo A, Shimizu K, Abe S, Moriyama K, Yasuda S, Hashimoto Y, Kurushima J, Mikuriya S, Imai FL, Adachi N, Kawasaki M, Sato Y, Ogasawara S, Iwata S, Senda T, Ikeguchi M, Tomita H, Iino R, Moriya T, Murata T
SARS-CoV-2 evolution balances conflicting roles of N protein phosphorylation.
1. PLoS Pathog - published November 2, 2024
2. Syed AM, Ciling A, Chen IP, Carlson CR, Adly AN, Martin HS, Taha TY, Khalid MM, Price N, Bouhaddou M, Ummadi MR, Moen JM, Krogan NJ, Morgan DO, Ott M, Doudna JA
In memoriam: Ana Jonas, PhD.
1. J Lipid Res - published November 2, 2024
2. Anne-Rye K, Davidson WS
Lymphocytic choriomeningitis arenavirus utilises intercellular connections for cell to cell spread.
1. Sci Rep - published November 2, 2024
2. Byford O, Shaw AB, Tse HN, Moon-Walker A, Saphire EO, Whelan SPJ, Stacey M, Hewson R, Fontana J, Barr JN
Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.
1. Nat Commun - published November 2, 2024
2. Mabanglo MF, Wilson B, Noureldin M, Kimani SW, Mamai A, Krausser C, González-Álvarez H, Srivastava S, Mohammed M, Hoffer L, Chan M, Avrumutsoae J, Li ASM, Hajian T, Tucker S, Green S, Szewczyk M, Barsyte-Lovejoy D, Santhakumar V, Ackloo S, Loppnau P, Li Y, Seitova A, Kiyota T, Wang JG, Privé GG, Kuntz DA, Patel B, Rathod V, Vala A, Rout B, Aman A, Poda G, Uehling D, Ramnauth J, Halabelian L, Marcellus R, Al-Awar R, Vedadi M
The neonatal Fc receptor is a cellular receptor for human astrovirus.
1. Nat Microbiol - published November 2, 2024
2. Ingle H, Molleston JM, Hall PD, Bui D, Wang L, Bhatt KD, Foster L, Antia A, Ding S, Lee S, Fremont DH, Baldridge MT
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification.
1. Cell - published November 2, 2024
2. Liu B, Wu T, Miao BA, Ji F, Liu S, Wang P, Zhao Y, Zhong Y, Sundaram A, Zeng TB, Majcherska-Agrawal M, Keenan RJ, Pan T, He C
Optimized Production of Concanamycins Using a Rational Metabolic Engineering Strategy.
1. Metab Eng - published November 2, 2024
2. Pereira F, McCauley M, Lev K, Verhey-Henke L, Condren AR, Harte RJ, Galvez J, Sherman DH
Structural mechanisms of human sodium-coupled high-affinity choline transporter CHT1.
1. Cell Discov - published November 2, 2024
2. Xue J, Chen H, Wang Y, Jiang Y
Protein data bank: From two epidemics to the global pandemic to mRNA vaccines and Paxlovid.
1. Curr Opin Struct Biol - published November 2, 2024
2. Burley SK
Discovery of Nanosota-9 as anti-Omicron nanobody therapeutic candidate.
1. PLoS Pathog - published November 2, 2024
2. Ye G, Bu F, Saxena D, Turner-Hubbard H, Herbst M, Spiller B, Wadzinski BE, Du L, Liu B, Zheng J, Li F
Bacterial WYL domain transcriptional repressors sense single-stranded DNA to control gene expression.
1. Nucleic Acids Res - published November 2, 2024
2. Blankenchip CL, Corbett KD
Structural characterization of human monoclonal antibodies targeting uncommon antigenic sites on spike glycoprotein of SARS-CoV.
1. J Clin Invest - published November 2, 2024
2. Suryadevara N, Kose N, Bangaru S, Binshtein E, Munt J, Martinez DR, Schäfer A, Myers L, Scobey TD, Carnahan RH, Ward AB, Baric RS, Crowe JE Jr
Global analysis of endogenous protein disorder in cells.
1. Nat Methods - published November 2, 2024
2. Zhang S, Owyong TC, Sanislav O, Englmaier L, Sui X, Wang G, Greening DW, Williamson NA, Villunger A, White JM, Heras B, Wong WWH, Fisher PR, Hong Y
Preparation of Polarity-Marked Microtubules Using a Plus-End Capping DARPin.
1. Bio Protoc - published November 2, 2024
2. Henkin G, Brito C, Plückthun A, Surrey T
Comprehensive Assessment of Initial Adaptation of ESBL Positive ST131 Escherichia coli to Carbapenem Exposure.
1. J Infect Dis - published November 2, 2024
2. Shropshire WC, Song X, Bremer J, Seo S, Rodriguez S, Selvaraj Anand S, Dinh AQ, Bhatti MM, Konovalova A, Arias CA, Kalia A, Shamoo Y, Shelburne SA
Structural Transition of NRC4 to Hexameric Resistosome Activates Plant Immunity.
1. Mol Plant - published November 2, 2024
2. Ashraf MA, Rashidzade M
A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development.
1. Angew Chem Int Ed Engl - published November 2, 2024
2. Fan AT, Gadbois GE, Huang HT, Chaudhry C, Jiang J, Sigua LH, Smith ER, Wu S, Poirier GJ, Dunne-Dombrink K, Goyal P, Tao AJ, Sellers WR, Fischer ES, Donovan KA, Ferguson FM
The High-Resolution Structure of a Variable Lymphocyte Receptor From Petromyzon marinus Capable of Binding to the Brain Extracellular Matrix.
1. Proteins - published November 2, 2024
2. Appelt EA, Thoden JB, Gehrke SA, Bachmeier HD, Rayment I, Shusta EV, Holden HM
A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing.
1. Science - published November 2, 2024
2. Zheng G, Yin M, Mehta S, Chu IT, Wang S, AlShaye A, Drainville K, Buyanbat A, Bienfait F, Tenglin K, Zhu Q, Orkin SH
Molecular basis of mRNA delivery to the bacterial ribosome.
1. Science - published November 2, 2024
2. Webster MW, Chauvier A, Rahil H, Graziadei A, Charles K, Miropolskaya N, Takacs M, Saint-André C, Rappsilber J, Walter NG, Weixlbaumer A
Multiple mechanisms for licensing human replication origins.
1. Nature - published November 2, 2024
2. Yang R, Hunker O, Wise M, Bleichert F
The pentameric chloride channel BEST1 is activated by extracellular GABA.
1. bioRxiv - published November 2, 2024
2. Pant S, Tam SW, Long SB
Determination of Pseudomonas aeruginosa MexXY-OprM substrate profile in a major efflux knockout system reveals distinct antibiotic substrate classes.
1. bioRxiv - published November 2, 2024
2. Kavanaugh LG, Hariharan SM, Conn GL
Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second strand nicking.
1. bioRxiv - published November 2, 2024
2. Thawani A, Rodríguez-Vargas A, Van Treeck B, Hassan NT, Adelson DL, Nogales E, Collins K
Machine learning application to predict binding affinity between peptide containing non-canonical amino acids and HLA0201.
1. bioRxiv - published November 2, 2024
2. Jiang S, Su Z, Bloodworth N, Liu Y, Martina C, Harrison DG, Meiler J
Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway.
1. bioRxiv - published November 2, 2024
2. Ye Q, Gong M, Chambers LR, Corbett KD
Structural diversity and oligomerization of bacterial ubiquitin-like proteins.
1. bioRxiv - published November 2, 2024
2. Gong M, Ye Q, Gu Y, Chambers LR, Bobkov AA, Arakawa NK, Matyszewski M, Corbett KD
SuperWater: Predicting Water Molecule Positions on Protein Structures by Generative AI.
1. bioRxiv - published November 2, 2024
2. Kuang X, Su Z, Liu YL, Lin X, Spencer-Smith J, Derr T, Wu Y, Meiler J
Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia.
1. Sci Adv - published November 2, 2024
2. Martínez-Rivera A, Fetcho RN, Birmingham L, Xu J, Yang R, Foord C, Scala-Chávez D, Mekawy N, Pleil K, Pickel VM, Liston C, Castorena CM, Levitz J, Pan YX, Briand LA, Rajadhyaksha AM, Lee FS
Supporting structural biologists in Africa requires resources and capacity building.
1. Nat Struct Mol Biol - published November 2, 2024
2. Nji E, Moumbock AFA, Cramer KC, Rüffin NV, Davis J, Asojo OA, Griese JJ, Larbi AA, Fodje MN
Self-organized spatial targeting of contractile actomyosin rings for synthetic cell division.
1. Nat Commun - published November 2, 2024
2. Reverte-López M, Kanwa N, Qutbuddin Y, Belousova V, Jasnin M, Schwille P
Elucidating the phytotoxic endpoints of sub-chronic exposure to titanium dioxide nanoparticles in Endemic Persian Dracocephalum Species.
1. Chemosphere - published November 2, 2024
2. Chahardoli A, Sharifan H
Artesunate: a potential drug for the prevention and treatment from hepatitis to hepatocellular carcinoma.
1. Pharmacol Res - published November 2, 2024
2. Liu X, Cai Y, Zhang Y, Zhang H, Tian S, Gong Y, Song Q, Chen X, Ma X, Wen Y, Chen Y, Zeng J
Loop-extrusion-mediated plasmid DNA cleavage by the bacterial SMC Wadjet complex.
1. Mol Cell - published November 2, 2024
2. Pradhan B, Deep A, König J, Baaske MD, Corbett KD, Kim E
GABA(A) receptor π forms channels that stimulate ERK through a G-protein-dependent pathway.
1. Mol Cell - published November 2, 2024
2. Wang Y, Zhang Y, Li W, Salovska B, Zhang J, Li T, Li H, Liu Y, Kaczmarek LK, Pusztai L, Klein DE
Cost-benefit analysis of cryogenic electron tomography subtomogram averaging of chaperonin MmCpn at near atomic resolution.
1. Structure - published November 2, 2024
2. Zhao Y, Schmid MF, Chiu W
Development of a Rapid Visual Detection Assay for Duck Tembusu Virus Using RT-LAMP-CRISPR/Cas12a.
1. Animals (Basel) - published November 2, 2024
2. Chen J, Tao D, Yang F, Pan C, Bao X, Xie S, Gong P, Zhao C, Lin R
EMhub: a web platform for data management and on-the-fly processing in scientific facilities.
1. Acta Crystallogr D Struct Biol - published November 1, 2024
2. de la Rosa-Trevin JM, Sharov G, Fleischmann S, Morado D, Bollinger JC, Miller DJ, Terry DS, Blanchard SC, Fernandez IS, Carroni M
Expression and characterization of pantothenate energy-coupling factor transporters as an anti-infective drug target.
1. Protein Sci - published November 1, 2024
2. Shams A, Bousis S, Diamanti E, Elgaher WAM, Zeimetz L, Haupenthal J, Slotboom DJ, Hirsch AKH
Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors.
1. Protein Sci - published November 1, 2024
2. Cazzanelli G, Dalle Vedove A, Sbardellati N, Valer L, Caflisch A, Lolli G
Variable orthogonality of serine integrase interactions within the ϕC31 family.
1. Sci Rep - published November 1, 2024
2. MacDonald AI, Baksh A, Holland A, Shin H, Rice PA, Stark WM, Olorunniji FJ
The structures of protein kinase A in complex with CFTR: Mechanisms of phosphorylation and noncatalytic activation.
1. Proc Natl Acad Sci U S A - published November 1, 2024
2. Fiedorczuk K, Iordanov I, Mihályi C, Szollosi A, Csanády L, Chen J
Improved In Vivo Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications.
1. Org Lett - published November 1, 2024
2. Datta D, Kumar P, Kundu J, Qin J, Gilbert JA, Schofield S, Donnelly DP, Liu J, Degaonkar R, Egli M, Manoharan M
Patient centered HCC surveillance - complementary roles of ultrasound and CT/MRI.
1. Abdom Radiol (NY) - published November 1, 2024
2. Heald J, Fetzer DT, Rodgers S, Jain V, Fung A, Liu X, Wilson S, Kamaya A, Marks RM
Dimming the corona: studying SARS-coronavirus-2 at reduced biocontainment level using replicons and virus-like particles.
1. mBio - published November 1, 2024
2. Neilsen G, Mathew AM, Castro JM, McFadden WM, Wen X, Ong YT, Tedbury PR, Lan S, Sarafianos SG
Synthesis of a Truncated Microcystin Tetrapeptide Molecule from a Partial Mcy Gene Cluster in Microcystis Cultures and Blooms.
1. Environ Sci Technol - published November 1, 2024
2. Yancey CE, Hart L, Lad AC, Birbeck JA, Song S, Mohamed OG, Fribley AM, Haller ST, Tripathi A, Kennedy DJ, Westrick JA, Sherman DH, Dick GJ
Channel width modulates the permeability of DNA origami-based nuclear pore mimics.
1. Sci Adv - published November 1, 2024
2. Feng Q, Saladin M, Wu C, Cao E, Zheng W, Zhang A, Bhardwaj P, Li X, Shen Q, Kapinos LE, Kozai T, Mariappan M, Lusk CP, Xiong Y, Lim RYH, Lin C
Architecture and activation of single-pass transmembrane receptor guanylyl cyclase.
1. Nat Struct Mol Biol - published November 1, 2024
2. Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Attenuation of high-fat diet-induced weight gain by apolipoprotein A4.
1. Obesity (Silver Spring) - published November 1, 2024
2. Kuo HN, LaRussa Z, Xu FM, Consitt LA, Liu M, Davidson WS, Puri V, Coschigano KT, Shi H, Lo CC
Systematic screens for fertility genes essential for malaria parasite transmission reveal conserved aspects of sex in a divergent eukaryote.
1. Cell Syst - published November 1, 2024
2. Sayers C, Pandey V, Balakrishnan A, Michie K, Svedberg D, Hunziker M, Pardo M, Choudhary J, Berntsson R, Billker O
Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants.
1. EMBO J - published November 1, 2024
2. Ke Z, Peacock TP, Brown JC, Sheppard CM, Croll TI, Kotecha A, Goldhill DH, Barclay WS, Briggs JAG
Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses.
1. PLoS Pathog - published November 1, 2024
2. Tse AL, Acreman CM, Ricardo-Lax I, Berrigan J, Lasso G, Balogun T, Kearns FL, Casalino L, McClain GL, Chandran AM, Lemeunier C, Amaro RE, Rice CM, Jangra RK, McLellan JS, Chandran K, Miller EH
Protective threshold of a potent neutralizing Zika virus monoclonal antibody in rhesus macaques.
1. J Virol - published November 1, 2024
2. Nkolola JP, Hope D, Guan R, Colarusso A, Aid M, Weiss D, Misamore J, Andersen H, Lewis MG, Williamson L, Carnahan RH, Crowe JE Jr, Barouch DH
Metagenomic sequencing of cyanobacterial-dominated Lake Victoria-an African Great Lake.
1. Microbiol Resour Announc - published November 1, 2024
2. Zepernick BN, Hart LN, Natwora KE, Brown KM, Obuya JA, Olokotum M, Okech EO, Keating NG, Lomeo D, Tebbs EJ, NSF-IRES 2022-2023 Lake Victoria Research Consortium, Sheik CS, Sherman DH, Dick GJ, Wilhelm SW, Drouillard KG, Lawrence T, Getabu A, Owuor B, Shitandi A, Omondi R, Njiru J, Sitoki L, Otiso KM, McKay RML, Bullerjahn GS
Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases.
1. Nat Commun - published November 1, 2024
2. Scott DC, Chittori S, Purser N, King MT, Maiwald SA, Churion K, Nourse A, Lee C, Paulo JA, Miller DJ, Elledge SJ, Harper JW, Kleiger G, Schulman BA
On the specificity of the recognition of m6A-RNA by YTH reader domains.
1. J Biol Chem - published November 1, 2024
2. Widmer J, Vitalis A, Caflisch A
Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation.
1. Nucleic Acids Res - published November 1, 2024
2. Niedner-Boblenz A, Monecke T, Hennig J, Klostermann M, Hofweber M, Davydova E, Gerber AP, Anosova I, Mayer W, Müller M, Heym RG, Janowski R, Paillart JC, Dormann D, Zarnack K, Sattler M, Niessing D
Structural aspects of CEACAM1 interactions.
1. Eur J Clin Invest - published November 1, 2024
2. Gandhi AK, Huang YH, Sun ZJ, Kim WM, Kondo Y, Hanley T, Beauchemin N, Blumberg RS
Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ.
1. Elife - published November 1, 2024
2. Shang J, Kojetin DJ
Alternative splicing modulates chromatin interactome and phase separation of the RIF1 C-terminal domain.
1. bioRxiv - published November 1, 2024
2. Koo AS, Jia W, Kim SH, Scalf M, Boos CE, Chen Y, Wang D, Voter AF, Bajaj A, Smith LM, Keck JL, Bakkenist CJ, Guo L, Tibbetts RS
A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein.
1. bioRxiv - published November 1, 2024
2. Abu-Shmais AA, Guo L, Khalil AM, Miller RJ, Janke AK, Vukovich MJ, Bass LE, Suresh YP, Rush SA, Wolters RM, Kose N, Carnahan RH, Crowe JE Jr, Bonami RH, Mousa JJ, McLellan JS, Georgiev IS
ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion.
1. Cell Metab - published November 1, 2024
2. Zhu R, Ye X, Lu X, Xiao L, Yuan M, Zhao H, Guo D, Meng Y, Han H, Luo S, Wu Q, Jiang X, Xu J, Tang Z, Tao YJ, Lu Z
A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice.
1. Cell Host Microbe - published November 1, 2024
2. Case JB, Sanapala S, Dillen C, Rhodes V, Zmasek C, Chicz TM, Switzer CE, Scheaffer SM, Georgiev G, Jacob-Dolan C, Hauser BM, Dos Anjos DCC, Adams LJ, Soudani N, Liang CY, Ying B, McNamara RP, Scheuermann RH, Boon ACM, Fremont DH, Whelan SPJ, Schmidt AG, Sette A, Grifoni A, Frieman MB, Diamond MS
Association of stressful life events with subjective age and the mediating role of depression: A cross-sectional study of older adults in China.
1. J Psychosom Res - published November 1, 2024
2. Liu X, Lin J, Shi J, Zhao Q
Highly multiplexed design of an allosteric transcription factor to sense new ligands.
1. Nat Commun - published November 1, 2024
2. Nishikawa KK, Chen J, Acheson JF, Harbaugh SV, Huss P, Frenkel M, Novy N, Sieren HR, Lodewyk EC, Lee DH, Chávez JL, Fox BG, Raman S
Efficient convergent synthesis of 1,3-diazepinone nucleosides by ring-closing metathesis and direct glycosylation.
1. RSC Adv - published November 1, 2024
2. Hedger AK, Findell J, Barak DS, Schiffer CA, Watts JK, Ali A
Structure and dynamics of the active site of hen egg-white lysozyme from atomic resolution neutron crystallography.
1. Structure - published November 1, 2024
2. Ramos J, Laux V, Mason SA, Lemée MH, Bowler MW, Diederichs K, Haertlein M, Forsyth VT, Mossou E, Larsen S, Langkilde AE
Latent-TGF-β has a domain swapped architecture.
1. Res Sq - published November 1, 2024
2. Nishimura S, Jin M, Seed R, Shing T, Cheng Y
FZD5 controls intestinal crypt homeostasis and colonic Wnt surrogate agonist response.
1. Dev Cell - published November 1, 2024
2. Mu Q, Ha A, Santos AJM, Lo YH, van Unen V, Miao Y, Tomaske M, Guzman VK, Alwahabi S, Yuan JJ, Deng L, Li L, Garcia KC, Kuo CJ
In vivo Treatment of a Severe Vascular Disease via a Bespoke CRISPR-Cas9 Base Editor.
1. bioRxiv - published November 1, 2024
2. Alves CRR, Das S, Krishnan V, Ha LL, Fox LR, Stutzman HE, Shamber CE, Kalailingam P, McCarthy S, Lino Cardenas CL, Fong CE, Imai T, Mitra S, Yun S, Wood RK, Benning FMC, Lawton J, Kim N, Silverstein RA, da Silva JF, de la Cruz D, Richa R, Malhotra R, Chung DY, Chao LH, Tsai SQ, Maguire CA, Lindsay ME, Kleinstiver BP, Musolino PL
WelQrate: Defining the Gold Standard in Small Molecule Drug Discovery Benchmarking.
1. ArXiv - published November 1, 2024
2. Liu YL, Dong H, Wang X, Moretti R, Wang Y, Su Z, Gu J, Bodenheimer B, Weaver CD, Meiler J, Derr T
Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization.
1. RSC Chem Biol - published November 1, 2024
2. Roßmann K, Birke R, Levitz J, Jones B, Broichhagen J