Member Publications

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149 Member Publications for October 2024

Do COVID-19 Infectious Disease Models Incorporate the Social Determinants of Health? A Systematic Review.
1. Public Health Rev - published October 25, 2024
2. John-Baptiste AA, Moulin M, Li Z, Hamilton D, Crichlow G, Klein DE, Alemu FW, Ghattas L, McDonald K, Asaria M, Sharpe C, Pandya E, Moqueet N, Champredon D, Moghadas SM, Cooper LA, Pinto A, Stranges S, Haworth-Brockman MJ, Galvani A, Ali S
AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution.
1. Nature - published October 9, 2024
2. Schade AE, Perurena N, Yang Y, Rodriguez CL, Krishnan A, Gardner A, Loi P, Xu Y, Nguyen VTM, Mastellone GM, Pilla NF, Watanabe M, Ota K, Davis RA, Mattioli K, Xiang D, Zoeller JJ, Lin JR, Morganti S, Garrido-Castro AC, Tolaney SM, Li Z, Barbie DA, Sorger PK, Helin K, Santagata S, Knott SRV, Cichowski K
A modular circuit coordinates the diversification of courtship strategies.
1. Nature - published October 9, 2024
2. Coleman RT, Morantte I, Koreman GT, Cheng ML, Ding Y, Ruta V
A multispecific antibody against SARS-CoV-2 prevents immune escape in vitro and confers prophylactic protection in vivo.
1. Sci Transl Med - published October 9, 2024
2. Misasi J, Wei RR, Wang L, Pegu A, Wei CJ, Oloniniyi OK, Zhou T, Moliva JI, Zhao B, Choe M, Yang ES, Zhang Y, Boruszczak M, Chen M, Leung K, Li J, Yang ZY, Andersen H, Carlton K, Godbole S, Harris DR, Henry AR, Ivleva VB, Lei QP, Liu C, Longobardi L, Merriam JS, Nase D, Olia AS, Pessaint L, Porto M, Shi W, Wallace SM, Wolff JJ, Douek DC, Suthar MS, Gall JG, Koup RA, Kwong PD, Mascola JR, Nabel GJ, Sullivan NJ
Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements.
1. Commun Biol - published October 9, 2024
2. Raimondi F, Siow KM, Wrona D, Fuster-García C, Pastukhov O, Schmitz M, Bargsten K, Kissling L, Swarts DC, Andrieux G, Cathomen T, Modlich U, Jinek M, Siler U, Reichenbach J
Steering research on mRNA splicing in cancer towards clinical translation.
1. Nat Rev Cancer - published October 9, 2024
2. Anczukow O, Allain FH, Angarola BL, Black DL, Brooks AN, Cheng C, Conesa A, Crosse EI, Eyras E, Guccione E, Lu SX, Neugebauer KM, Sehgal P, Song X, Tothova Z, Valcárcel J, Weeks KM, Yeo GW, Thomas-Tikhonenko A
Structural basis of μ-opioid receptor targeting by a nanobody antagonist.
1. Nat Commun - published October 9, 2024
2. Yu J, Kumar A, Zhang X, Martin C, Van Holsbeeck K, Raia P, Koehl A, Laeremans T, Steyaert J, Manglik A, Ballet S, Boland A, Stoeber M
UHPLC-Q/Orbitrap HRMS combined with spectrum-effect relationship and network pharmacology to discovery the gastrointestinal motility-promoting material basis in Citri Sarcodactylis Fructus.
1. J Ethnopharmacol - published October 9, 2024
2. Liu X, Gong Q, Deng X, Li L, Luo R, Li X, Guo D, Deng F
Effects of polyphenols from Tasmannia lanceolata on structural, emulsifying, and antioxidant properties of pea protein.
1. Food Chem - published October 9, 2024
2. Kim W, Zia MB, Naik RR, Ho KKHY, Selomulya C
Gut Bacteria Metabolize Natural and Synthetic Steroid Hormones via the Reductive OsrABC Pathway.
1. bioRxiv - published October 9, 2024
2. Jacoby C, Scorza K, Ecker L, McMillin M, Ramaswamy R, Sundararajan A, Sidebottom AM, Lin H, Dufault-Thompson K, Hall B, Jiang X, Light SH
TRIM37 employs peptide motif recognition and substrate-dependent oligomerization to prevent ectopic spindle pole assembly.
1. bioRxiv - published October 9, 2024
2. Bellaart A, Brambila A, Xu J, Mendez Diaz F, Deep A, Anzola J, Meitinger F, Ohta M, Corbett KD, Desai A, Oegema K
Capturing a methanogenic carbon monoxide dehydrogenase/acetyl-CoA synthase complex via cryogenic electron microscopy.
1. Proc Natl Acad Sci U S A - published October 8, 2024
2. Biester A, Grahame DA, Drennan CL
Mex3a Protects Against Atherosclerosis: Evidence From Mice and Humans.
1. Circulation - published October 8, 2024
2. Santovito D, Henderson JM, Bidzhekov K, Triantafyllidou V, Jansen Y, Chen Z, Farina FM, Diagel A, Aslani M, Blanchet X, Schunkert H, Megens RTA, Döring Y, Sattler M, Weber C
Structural basis for Vipp1 membrane binding: from loose coats and carpets to ring and rod assemblies.
1. Nat Struct Mol Biol - published October 8, 2024
2. Junglas B, Kartte D, Kutzner M, Hellmann N, Ritter I, Schneider D, Sachse C
Enhanced Staphylococcus aureus protection by uncoupling of the α-toxin-ADAM10 interaction during murine neonatal vaccination.
1. Nat Commun - published October 8, 2024
2. Tomaszewski KL, Blanchard M, Olaniyi R, Brenton HR, Hayes S, Fatma F, Amarasinghe GK, Cho BK, Goo YA, DeDent AC, Fritz SA, Wardenburg JB
Targeting the Hippo pathway in Schwann cells ameliorates peripheral nerve degeneration via a polypharmacological mechanism.
1. Neurotherapeutics - published October 8, 2024
2. Chung HJ, Nguyen TNC, Lee JW, Huh Y, Ko S, Lim H, Seo H, Ha YG, Chang JH, Woo JS, Song JJ, Kim SW, Lee JS, Mo JS, Park B, Min KW, Yoon JH, Kim MS, Jung J, Jeong NY
Structure of TnsABCD transpososome reveals mechanisms of targeted DNA transposition.
1. Cell - published October 8, 2024
2. Wang S, Siddique R, Hall MC, Rice PA, Chang L
Evidence for phospholipid self-organisation in concentrated ammonia-water environments.
1. Biochim Biophys Acta Biomembr - published October 8, 2024
2. Mackay SM, Sutherland B, Easingwood RA, Hopkins A, Bostina M, Tan EW
MreC-MreD structure reveals a multifaceted interface that controls MreC conformation.
1. bioRxiv - published October 8, 2024
2. Gilman MSA, Shlosman I, Guerra DDS, Domecillo M, Fivenson EM, Bourett C, Bernhardt TG, Polizzi NF, Loparo JJ, Kruse AC
Self-assembly and condensation of intermolecular poly(UG) RNA quadruplexes.
1. Nucleic Acids Res - published October 7, 2024
2. Roschdi S, Montemayor EJ, Vivek R, Bingman CA, Butcher SE
Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway.
1. J Am Chem Soc - published October 7, 2024
2. Aluri KC, Datta D, Waldron S, Taneja N, Qin J, Donnelly DP, Theile CS, Guenther DC, Lei L, Harp JM, Pallan PS, Egli M, Zlatev I, Manoharan M
Cellular NS1-BP Protein Interacts with the mRNA Export Receptor NXF1 to Mediate Nuclear Export of Influenza Virus M mRNAs.
1. J Biol Chem - published October 7, 2024
2. Zhang K, Cagatay T, Xie D, Angelos AE, Cornelius S, Aksenova V, Aslam S, He Z, Esparza M, Vazhavilla A, Dasso M, García-Sastre A, Ren Y, Fontoura BMA
The membrane curvature-inducing REEP1-4 proteins generate an ER-derived vesicular compartment.
1. Nat Commun - published October 5, 2024
2. Shibata Y, Mazur EE, Pan B, Paulo JA, Gygi SP, Chavan S, Valerio LSA, Zhang J, Rapoport TA
The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses.
1. Cell Rep - published October 5, 2024
2. Palakurty S, Raju S, Sariol A, Chong Z, Wagoner N, Ma H, Zimmerman O, Adams LJ, Carmona C, Liu Z, Fremont DH, Whelan SPJ, Klimstra WB, Diamond MS
Experimental variables determine the outcome of RAS-RAS interactions.
1. J Biol Chem - published October 5, 2024
2. Zhou Z, Nguyen TL, Li X, Poujol C, Berlinska E, Michelina SV, Kapp JN, Plückthun A, Winslow MM, Ambrogio C, Shan Y, Santamaría D, Westover KD
NusG-Spt5 Transcription Factors: Universal, Dynamic Modulators of Gene Expression.
1. J Mol Biol - published October 5, 2024
2. Mooney RA, Zhu J, Saba J, Landick R
The role of structure in regulatory RNA elements.
1. Biosci Rep - published October 4, 2024
2. Tants JN, Schlundt A
Platelet integrin αIIbβ3 plays a key role in a venous thrombogenesis mouse model.
1. Nat Commun - published October 4, 2024
2. Adair BD, Field CO, Alonso JL, Xiong JP, Deng SX, Ahn HS, Mashin E, Clish CB, van Agthoven J, Yeager M, Guo Y, Tess DA, Landry DW, Poncz M, Arnaout MA
Activity and phosphatidylcholine transfer protein interactions of skeletal muscle thioesterase Them2 enable hepatic steatosis and insulin resistance.
1. J Biol Chem - published October 4, 2024
2. Xie Y, Liu X, Liu W, Carr LR, Lee LP, Imai N, Ortlund EA, Cohen DE
Shortening the early diagnostic window of Hg(2+)-induced liver injury with a H(2)O(2)-activated fluorescence/afterglow imaging assay.
1. J Hazard Mater - published October 4, 2024
2. Li L, Li J, Liu X, Zhao X, Zhang A, Deng Y, Peng C, Cao Z, Dehaen W, Fang Y
Exploring the energetic and conformational properties of the sequence space connecting naturally occurring RNA tetraloop receptor motifs.
1. RNA - published October 3, 2024
2. Shin JH, Cuevas LM, Roy R, Bonilla SL, Al-Hashimi H, Greenleaf WJ, Herschlag D
Regulation and signaling of the LIM domain kinases.
1. Bioessays - published October 3, 2024
2. Casanova-Sepúlveda G, Boggon TJ
Long-term follow-up of givosiran treatment in patients with acute intermittent porphyria from a phase 1/2, 48-month open-label extension study.
1. Orphanet J Rare Dis - published October 3, 2024
2. Sardh E, Balwani M, Rees DC, Anderson KE, Jia G, Sweetser MT, Wang B
Interactions that define the arrangement of sugar-binding sites in BDCA-2 and dectin-2 dimers.
1. Glycobiology - published October 3, 2024
2. Liu Y, Kim JW, Feinberg H, Cull N, Weis WI, Taylor ME, Drickamer K
Recent advances in correlative cryo-light and electron microscopy.
1. Curr Opin Struct Biol - published October 3, 2024
2. Pierson JA, Yang JE, Wright ER
PRC2-RNA interactions: Viewpoint from Tom Cech, Chen Davidovich, and Richard Jenner.
1. Mol Cell - published October 3, 2024
2. Cech TR, Davidovich C, Jenner RG
Cryo-EM vs. Disease X.
1. Cell - published October 3, 2024
2. Coulibaly F
Which cryptic sites are feasible drug targets?
1. Drug Discov Today - published October 3, 2024
2. Lazou M, Kozakov D, Joseph-Mccarthy D, Vajda S
Nature-inspired recycling of a protein mixture into a green fluorescent protein-based hydrogel.
1. RSC Sustain - published October 3, 2024
2. Roset Julià L, Maerkl SJ, Stellacci F
Dynamic interplay between a TonB-dependent heme transporter and a TonB protein in a membrane environment.
1. mBio - published October 3, 2024
2. Somboon K, Melling O, Lejeune M, Pinheiro GMS, Paquelin A, Bardiaux B, Nilges M, Delepelaire P, Khalid S, Izadi-Pruneyre N
Activity and cryo-EM structure of the polymerase domain of the human norovirus ProPol precursor.
1. J Virol - published October 3, 2024
2. McSweeney AM, Eruera A-R, McKenzie-Goldsmith GM, Bouwer JC, Brown SHJ, Stubbing LA, Hubert JG, Shrestha R, Sparrow KJ, Brimble MA, Harris LD, Evans GB, Bostina M, Krause KL, Ward VK
Electron tomography visualization of HIV-1 virions trapped by fusion inhibitors to host cells in infected tissues.
1. J Virol - published October 3, 2024
2. Ladinsky MS, Zhu L, Ullah I, Uchil PD, Kumar P, Kay MS, Bjorkman PJ
A bacterial transcription activator dedicated to the expression of the enzyme catalyzing the first committed step in fatty acid biosynthesis.
1. Nucleic Acids Res - published October 3, 2024
2. Xu Y, Lin Z, Hou J, Ye K, Han S, Liang Y, Liang H, Wu S, Tao YJ, Gao H
PilY1 regulates the dynamic architecture of the type IV pilus machine in Pseudomonas aeruginosa.
1. Nat Commun - published October 3, 2024
2. Guo S, Chang Y, Brun YV, Howell PL, Burrows LL, Liu J
Evading resistance at the double.
1. Nat Chem Biol - published October 3, 2024
2. Barmada MI, Conn GL
Engineered odorant receptors illuminate the basis of odour discrimination.
1. Nature - published October 3, 2024
2. de March CA, Ma N, Billesbølle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex.
1. Cell Commun Signal - published October 3, 2024
2. Hong S, Kim K, Shim YR, Park J, Choi SE, Min H, Lee S, Song JJ, Kang SJ, Jeong WI, Seong RH, Kim S
Development of a Limosilactobacillus reuteri therapeutic delivery platform with reduced colonization potential.
1. Appl Environ Microbiol - published October 3, 2024
2. Alexander LM, Khalid S, Gallego-Lopez GM, Astmann TJ, Oh J-H, Heggen M, Huss P, Fisher R, Mukherjee A, Raman S, Choi IY, Smith MN, Rogers CJ, Epperly MW, Knoll LJ, Greenberger JS, van Pijkeren J-P
Quality control for single-cell analysis of high-plex tissue profiles using CyLinter.
1. Nat Methods - published October 3, 2024
2. Baker GJ, Novikov E, Zhao Z, Vallius T, Davis JA, Lin JR, Muhlich JL, Mittendorf EA, Santagata S, Guerriero JL, Sorger PK
REliable PIcking by Consensus (REPIC): a consensus methodology for harnessing multiple cryo-EM particle pickers.
1. Commun Biol - published October 3, 2024
2. Cameron CJF, Seager SJH, Sigworth FJ, Tagare HD, Gerstein MB
Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress.
1. Cell - published October 3, 2024
2. Cao S, Garcia SF, Shi H, James EI, Kito Y, Shi H, Mao H, Kaisari S, Rona G, Deng S, Goldberg HV, Ponce J, Ueberheide B, Lignitto L, Guttman M, Pagano M, Zheng N
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.
1. bioRxiv - published October 2, 2024
2. Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CP, Bose R, Travaglini KJ, Lam VL, Goodness D, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan H, Carroll EC, Lawrence RE, Gestwicki JE, Eisenberg D, Kanaan NM, Southworth DR, Gross JD, Gan L, Swaney DL, Kampmann M
Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST.
1. bioRxiv - published October 2, 2024
2. Kraus F, He Y, Swarup S, Overmyer KA, Jiang Y, Brenner J, Capitanio C, Bieber A, Jen A, Nightingale NM, Anderson BJ, Lee C, Paulo JA, Smith IR, Plitzko JM, Gygi SP, Schulman BA, Wilfling F, Coon JJ, Harper JW
An interpretable deep learning framework identifies proteomic drivers of Alzheimer's disease.
1. Front Cell Dev Biol - published October 2, 2024
2. Panizza E, Cerione RA
Identification, characterization, and structure of a tRNA splicing enzyme RNA 5'-OH kinase from the pathogenic fungi Mucorales.
1. RNA - published October 2, 2024
2. Ghosh S, Wimberly-Gard G, Jacewicz A, Schwer B, Shuman S
Dramatic changes in mitochondrial subcellular location and morphology accompany activation of the CO(2) concentrating mechanism.
1. Proc Natl Acad Sci U S A - published October 2, 2024
2. Findinier J, Joubert LM, Fakhimi N, Schmid MF, Malkovskiy AV, Chiu W, Burlacot A, Grossman AR
Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling.
1. Nat Commun - published October 2, 2024
2. Zhang R, Jagessar KL, Brownd M, Polasa A, Stein RA, Moradi M, Karakas E, Mchaourab HS
Conformation matters: siRNAs with antisense strands with 5'-(E)-vinyl-phosphonate-α-L-LNA elicit stronger RNAi-mediated gene silencing than those with 5'-(E)-vinyl-phosphonate-LNA.
1. Chem Commun (Camb) - published October 2, 2024
2. Datta D, Kumar P, Mandal S, Krampert M, Egli M, Hrdlicka PJ, Manoharan M
DiffModeler: large macromolecular structure modeling for cryo-EM maps using a diffusion model.
1. Nat Methods - published October 2, 2024
2. Wang X, Zhu H, Terashi G, Taluja M, Kihara D
Clamping Pol ε to the leading strand.
1. Nat Struct Mol Biol - published October 2, 2024
2. Singh N, Johansson E
Discovery of Truncated Cyclic Peptides Targeting an Induced-Fit Pocket on PCSK9.
1. ChemMedChem - published October 2, 2024
2. Grosche P, Flyer AN, Gattlen R, Xu M, Golosov AA, Vera V, Pickett S, Brousseau ME, Chopra R, Clairmont KB, Koch A, Liu E, Reid P, Perry L, Yang L, Yang Q, Monovich LG
Reconstitution of Rab11-FIP4 Expression Rescues Cellular Homeostasis in Cystinosis.
1. Mol Cell Biol - published October 2, 2024
2. Rahman F, Johnson JL, Ait Kbaich M, Meneses-Salas E, Shukla A, Chen D, Kiosses WB, Gavathiotis E, Cuervo AM, Cherqui S, Catz SD
Characterization of Medusavirus encoded histones reveals nucleosome-like structures and a unique linker histone.
1. Nat Commun - published October 2, 2024
2. Toner CM, Hoitsma NM, Weerawarana S, Luger K
Dissecting the Conformational Heterogeneity of Stem-Loop Substructures of the Fifth Element in the 5'-Untranslated Region of SARS-CoV-2.
1. J Am Chem Soc - published October 2, 2024
2. Mertinkus KR, Oxenfarth A, Richter C, Wacker A, Mata CP, Carazo JM, Schlundt A, Schwalbe H
3D Cryo-Electron Microscopy Reveals the Structure of a 3-Fluorenylmethyloxycarbonyl Zipper Motif Ensuring the Self-Assembly of Tripeptide Nanofibers.
1. ACS Nano - published October 2, 2024
2. Bigo-Simon A, Estrozi LF, Chaumont A, Schurhammer R, Schoehn G, Combet J, Schmutz M, Schaaf P, Jierry L
Structurally Minimalized and Druglike TGase2 Inhibitors Based on 7-Aminoquinoline-5,8-dione Scaffolds for the Treatment of Diabetic Retinopathy.
1. J Med Chem - published October 2, 2024
2. Kang J, Jeon HY, Lee J, Bae S, Park GY, Min KJ, Joo J, Lee AJ, Kim HJ, Im CY, Kim EB, Lee JH, Hwang JS, Lee S, Lee JY, Navals P, Keillor JW, Ha KS, Song M
Supercharged fluorescent proteins detect lanthanides via direct antennae signaling.
1. Nat Commun - published October 2, 2024
2. Huang KY, Cardenas L, Ellington AD, Walker DJF
Orientation-dependent CD45 inhibition with viral and engineered ligands.
1. Sci Immunol - published October 2, 2024
2. Borowska MT, Liu LD, Caveney NA, Jude KM, Kim WJ, Masubuchi T, Hui E, Majzner RG, Garcia KC
Non-canonical amino acids for site-directed spin labeling of membrane proteins.
1. Curr Opin Struct Biol - published October 2, 2024
2. Ledwitch K, Künze G, Okwei E, Sala D, Meiler J
Hyaluronic acid-coated zein nanoparticle-mediated resveratrol therapy for the reduction of cisplatin-associated nephrotoxicity.
1. Biochem Biophys Res Commun - published October 2, 2024
2. Ning Y, Chen P, Shen Z, Liu X, Gu H
Young investigators in parasitology meeting: building foundations and supporting early-career researchers.
1. Trends Parasitol - published October 2, 2024
2. Rijo-Ferreira F, Ho CM, Rosenberg A
Engineered protein subunit COVID19 vaccine is as immunogenic as nanoparticles in mouse and hamster models.
1. Sci Rep - published October 2, 2024
2. Matthews MM, Kim TG, Kim KY, Meshcheryakov V, Iha HA, Tamai M, Sasaki D, Laurino P, Toledo-Patiño S, Collins M, Hsieh TY, Shibata S, Shibata N, Obata F, Fujii J, Ito T, Ito H, Ishikawa H, Wolf M
In-Situ Structure and Topography of AMPA Receptor Scaffolding Complexes Visualized by CryoET.
1. bioRxiv - published October 2, 2024
2. Held RG, Liang J, Esquivies L, Khan YA, Wang C, Azubel M, Brunger AT
Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
1. Cell - published October 2, 2024
2. Wang H, Cheng C, Dal Santo JL, Shen CH, Bylund T, Henry AR, Howe CA, Hwang J, Morano NC, Morris DJ, Pletnev S, Roark RS, Zhou T, Hansen BT, Hoyt FH, Johnston TS, Wang S, Zhang B, Ambrozak DR, Becker JE, Bender MF, Changela A, Chaudhary R, Corcoran M, Corrigan AR, Foulds KE, Guo Y, Lee M, Li Y, Lin BC, Liu T, Louder MK, Mandolesi M, Mason RD, McKee K, Nair V, O'Dell S, Olia AS, Ou L, Pegu A, Raju N, Rawi R, Roberts-Torres J, Sarfo EK, Sastry M, Schaub AJ, Schmidt SD, Schramm CA, Schwartz CL, Smith SC, Stephens T, Stuckey J, Teng IT, Todd JP, Tsybovsky Y, Van Wazer DJ, Wang S, Doria-Rose NA, Fischer ER, Georgiev IS, Karlsson Hedestam GB, Sheng Z, Woodward RA, Douek DC, Koup RA, Pierson TC, Shapiro L, Shaw GM, Mascola JR, Kwong PD
The CRISPR-associated adenosine deaminase Cad1 converts ATP to ITP to provide antiviral immunity.
1. Cell - published October 2, 2024
2. Baca CF, Majumder P, Hickling JH, Ye L, Teplova M, Brady SF, Patel DJ, Marraffini LA
Dynamic sampling of a surveillance state enables DNA proofreading by Cas9.
1. Cell Chem Biol - published October 2, 2024
2. De Paula VS, Dubey A, Arthanari H, Sgourakis NG
Dissecting the Membrane Association Mechanism of Aerolysin Pores at Femtomolar Concentrations Using Water as a Probe.
1. Nano Lett - published October 2, 2024
2. Roesel T, Cao C, Bada Juarez JF, Dal Peraro M, Roke S
Structural and biophysical characterisation of ubiquitin variants that inhibit the ubiquitin conjugating enzyme Ube2d2.
1. FEBS J - published October 2, 2024
2. McAlpine JMRB, Zhu G, Pudjihartono N, Teyra J, Currie MJ, Tillett ZD, Dobson RCJ, Sidhu SS, Day CL, Middleton AJ
Ovarian cancer-derived IL-4 promotes immunotherapy resistance.
1. Cell - published October 2, 2024
2. Mollaoglu G, Tepper A, Falcomatà C, Potak HT, Pia L, Amabile A, Mateus-Tique J, Rabinovich N, Park MD, LaMarche NM, Brody R, Browning L, Lin JR, Zamarin D, Sorger PK, Santagata S, Merad M, Baccarini A, Brown BD
IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion.
1. Cell - published October 2, 2024
2. Herhaus L, Gestal-Mato U, Eapen VV, Mačinković I, Bailey HJ, Prieto-Garcia C, Misra M, Jacomin AC, Ammanath AV, Bagarić I, Michaelis J, Vollrath J, Bhaskara RM, Bündgen G, Covarrubias-Pinto A, Husnjak K, Zöller J, Gikandi A, Ribičić S, Bopp T, van der Heden van Noort GJ, Langer JD, Weigert A, Harper JW, Mancias JD, Dikic I
A nanobody toolbox for recognizing distinct epitopes on Cas9.
1. J Mol Biol - published October 2, 2024
2. Boylan J, Shrem RA, Vallecillo-Viejo IC, Duvall CL, Wadzinski BE, Spiller BW
A high throughput single molecule platform to study DNA supercoiling effect on protein-DNA interactions.
1. bioRxiv - published October 2, 2024
2. Lee H, Hwang J, Rashid F, London JA, Fishel R, Berger JM, Myong S, Ha T
Cryo-EM structures of the Plasmodium falciparum apicoplast DNA polymerase.
1. J Mol Biol - published October 2, 2024
2. Lo CY, Ung AR, Koley T, Nelson SW, Gao Y
APOA2 Increases Cholesterol Efflux Capacity to Plasma HDL by Displacing the C-terminus of Resident APOA1.
1. J Lipid Res - published October 2, 2024
2. Sarkar S, Morris J, You Y, Sexmith H, Street SE, Thibert SM, Attah IK, Hutchinson Bunch CM, Novikova I, Evans J, Shah AS, Gordon SM, Segrest JP, Bornfeldt KE, Vaisar T, Heinecke JW, Davidson WS, Melchior JT
DNA nanodevice for analysis of force-activated protein extension and interactions.
1. bioRxiv - published October 2, 2024
2. Zhou K, Chung M, Cheng J, Powell JT, Liu J, Xiong Y, Schwartz MA, Lin C
Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons.
1. Nat Biotechnol - published October 1, 2024
2. Hergenreder E, Minotti AP, Zorina Y, Oberst P, Zhao Z, Munguba H, Calder EL, Baggiolini A, Walsh RM, Liston C, Levitz J, Garippa R, Chen S, Ciceri G, Studer L
Structural analysis and shape-based identification of novel inhibitors targeting the Trypanosoma cruzi proteasome.
1. Int J Biol Macromol - published October 1, 2024
2. Silva GM, Gomes SQ, Lopes CD, de Albuquerque S, de Paula da Silva CHT
Inherited PURA Pathogenic Variant Associated With a Mild Neurodevelopmental Disorder.
1. Neurol Genet - published October 1, 2024
2. Hildebrand MS, Braden RO, Lauretta ML, Kaspi A, Leventer RJ, Anderson M, Goel H, Bahlo M, Scheffer IE, Amor DJ, Janowski R, Niessing D, Morgan AT
Analysis of EGFR binding hotspots for design of new EGFR inhibitory biologics.
1. Protein Sci - published October 1, 2024
2. Tydings CW, Singh B, Smith AW, Ledwitch KV, Brown BP, Lovly CM, Walker AS, Meiler J
Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity.
1. Protein Sci - published October 1, 2024
2. Narayanan D, Larsen ASG, Gauger SJ, Adafia R, Hammershøi RB, Hamborg L, Bruus-Jensen J, Griem-Krey N, Gee CL, Frølund B, Stratton MM, Kuriyan J, Kastrup JS, Langkilde AE, Wellendorph P, Solbak SMØ
Ternary structure of Plasmodium vivaxN-myristoyltransferase with myristoyl-CoA and inhibitor IMP-0001173.
1. Acta Crystallogr F Struct Biol Commun - published October 1, 2024
2. Bolling C, Mendez A, Taylor S, Makumire S, Reers A, Zigweid R, Subramanian S, Dranow DM, Staker B, Edwards TE, Tate EW, Bell AS, Myler PJ, Asojo OA, Chakafana G
Alternating access of a bacterial homolog of neurotransmitter: sodium symporters determined from AlphaFold2 ensembles and DEER spectroscopy.
1. Proc Natl Acad Sci U S A - published October 1, 2024
2. Schwartz AC, Stein RA, Gil-Iturbe E, Quick M, Mchaourab HS
Structural basis for adhesin secretion by the outer-membrane usher in type 1 pili.
1. Proc Natl Acad Sci U S A - published October 1, 2024
2. Bitter RM, Zimmerman MI, Summers BT, Pinkner JS, Dodson KW, Hultgren SJ, Yuan P
Factors associated with the choice of treatment for coronoid fractures.
1. Bone Joint J - published October 1, 2024
2. de Klerk HH, Verweij LPE, Doornberg JN, Jaarsma RL, Murase T, Chen NC, van den Bekerom MPJ, and the Elbow Injury Management Consortium, and the Elbow Injury Management Consortium (EIMC), Al K, Ar B, Ac W, A VT, Ac AP, A T, A B, B M, B T, B J, Cs M, Cm L, Cg L, Cg T, C R, D R, Ds R, D E, E AG, E K, Et E, Gi B, Jn L, Ja W, J P, J A, K S, K S, Al B, Ms C, M M, Ml R, Mj S, N A, N W, Nwl S, P A, P M, R B, Rj T, R VR, R G, S S, Sd D, S T, T M, Y C
The molecular dissection of TRIM25's RNA-binding mechanism provides key insights into its antiviral activity.
1. Nat Commun - published October 1, 2024
2. Álvarez L, Haubrich K, Iselin L, Gillioz L, Ruscica V, Lapouge K, Augsten S, Huppertz I, Choudhury NR, Simon B, Masiewicz P, Lethier M, Cusack S, Rittinger K, Gabel F, Leitner A, Michlewski G, Hentze MW, Allain FHT, Castello A, Hennig J
Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair.
1. Nat Commun - published October 1, 2024
2. Yu J, Yan C, Paul T, Brewer L, Tsutakawa SE, Tsai CL, Hamdan SM, Tainer JA, Ivanov I
Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition.
1. Oncotarget - published October 1, 2024
2. Rackear M, Quijano E, Ianniello Z, Colón-Ríos DA, Krysztofiak A, Abdullah R, Liu Y, Rogers FA, Ludwig DL, Dwivedi R, Bleichert F, Glazer PM
SARS-CoV-2 ferritin nanoparticle vaccines produce hyperimmune equine sera with broad sarbecovirus activity.
1. iScience - published October 1, 2024
2. Martinez EJ, Chang WC, Chen WH, Hajduczki A, Thomas PV, Jensen JL, Choe M, Sankhala RS, Peterson CE, Rees PA, Kimner J, Soman S, Kuklis C, Mendez-Rivera L, Dussupt V, King J, Corbett C, Mayer SV, Fernandes A, Murzello K, Cookenham T, Hvizdos J, Kummer L, Hart T, Lanzer K, Gambacurta J, Reagan M, Duso D, Vasan S, Collins ND, Michael NL, Krebs SJ, Gromowski GD, Modjarrad K, Kaundinya J, Joyce MG
Biochemical simulation of mutation synthesis and repair during SARS-CoV-2 RNA polymerization.
1. Virology - published October 1, 2024
2. Oo A, Chen Z, Cao D, Cho YJ, Liang B, Schinazi RF, Kim B
The structural landscape of Microprocessor-mediated processing of pri-let-7 miRNAs.
1. Mol Cell - published October 1, 2024
2. Garg A, Shang R, Cvetanovic T, Lai EC, Joshua-Tor L
Erratum: Studying Orthodontic Tooth Movement in Mice.
1. J Vis Exp - published October 1, 2024
2. Dukes MJ, Gilmore BL, Tanner JR, McDonald SM, Kelly DF
Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions.
1. J Virol - published October 1, 2024
2. Trimarco JD, Spurrier MA, Skavicus S, Luo Z, Dutta M, Janowska K, Acharya P, Heaton BE, Heaton NS
Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation.
1. Proc Natl Acad Sci U S A - published October 1, 2024
2. Hu Y, Lopez VA, Xu H, Pfister JP, Song B, Servage KA, Sakurai M, Jones BT, Mendell JT, Wang T, Wu J, Lambowitz AM, Tomchick DR, Pawłowski K, Tagliabracci VS
How bacteria initiate DNA replication comes into focus.
1. Bioessays - published October 1, 2024
2. Rashid F, Berger JM
Structures of the Foamy virus fusion protein reveal an unexpected link with the F protein of paramyxo- and pneumoviruses.
1. Sci Adv - published October 1, 2024
2. Fernández I, Bontems F, Brun D, Coquin Y, Goverde CA, Correia BE, Gessain A, Buseyne F, Rey FA, Backovic M
Assessing Military Mental Health during the Pandemic: A Five Country Collaboration.
1. Curr Psychiatry Rep - published October 1, 2024
2. Lee JEC, Bennett C, Bennett N, Bouak F, Goldenberg I, Harrison K, Edge HM, Bell AM, Quartana PJ, Simms MA, Adler AB
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
1. Nat Commun - published October 1, 2024
2. Scott DC, Dharuman S, Griffith E, Chai SC, Ronnebaum J, King MT, Tangallapally R, Lee C, Gee CT, Yang L, Li Y, Loudon VC, Lee HW, Ochoada J, Miller DJ, Jayasinghe T, Paulo JA, Elledge SJ, Harper JW, Chen T, Lee RE, Schulman BA
Enhancing Spectrometer Performance with Unsupervised Machine Learning.
1. J Phys Chem B - published October 1, 2024
2. Harding BD, Hu Z, Hiett A, Delaglio F, Henzler-Wildman KA, Rienstra CM
Native Mass Spectrometry of Membrane Protein-Lipid Interactions in Different Detergent Environments.
1. Anal Chem - published October 1, 2024
2. Kumar S, Stover L, Wang L, Bahramimoghaddam H, Zhou M, Russell DH, Laganowsky A
Characterization of conformational states of the homodimeric enzyme fluoroacetate dehalogenase by (19)F-(13)C two-dimensional NMR.
1. RSC Chem Biol - published October 1, 2024
2. Suleiman M, Frere GA, Törner R, Tabunar L, Bhole GV, Taverner K, Tsuchimura N, Pichugin D, Lichtenecker RJ, Vozny O, Gunning P, Arthanari H, Sljoka A, Prosser RS
GoToCloud optimization of cloud computing environment for accelerating cryo-EM structure-based drug design.
1. Commun Biol - published October 1, 2024
2. Moriya T, Yamada Y, Yamamoto M, Senda T
TRPML1 gating modulation by allosteric mutations and lipids.
1. Elife - published October 1, 2024
2. Gan N, Han Y, Zeng W, Jiang Y
Molecular basis of cell membrane adaptation in daptomycin-resistant Enterococcus faecalis.
1. JCI Insight - published October 1, 2024
2. Nguyen AH, Tran TT, Panesso D, Hood KS, Polamraju V, Zhang R, Khan A, Miller WR, Mileykovskaya E, Shamoo Y, Xu L, Vitrac H, Arias CA
Advances and challenges in RAS signaling targeted therapy in leukemia.
1. Mol Cancer Ther - published October 1, 2024
2. Chen Y, Yin Z, Westover KD, Zhou Z, Shu L
Notch induces transcription by stimulating release of paused RNA polymerase II.
1. Genes Dev - published October 1, 2024
2. Rogers JM, Mimoso CA, Martin BJE, Martin AP, Aster JC, Adelman K, Blacklow SC
Total Synthesis and Structural Reassignment of the Antitubercular Natural Product Evybactin.
1. Chemistry - published October 1, 2024
2. Lysenko V, Son S, Theriault ME, Slingerland CJ, Hauk G, Cleenewerk L, Speer A, Berger JM, Lewis K, Martin N
Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa.
1. Nucleic Acids Res - published October 1, 2024
2. He S, Taher NM, Simard AR, Hvorecny KL, Ragusa MJ, Bahl CD, Hickman AB, Dyda F, Madden DR
Chikungunya virus E2 B domain nanoparticle immunogen elicits homotypic neutralizing antibody in mice.
1. Vaccine - published October 1, 2024
2. Tong K, Hernandez EM, Basore K, Fremont DH, Lai JR
Mechanism of bacterial predation via ixotrophy.
1. Science - published October 1, 2024
2. Lien YW, Amendola D, Lee KS, Bartlau N, Xu J, Furusawa G, Polz MF, Stocker R, Weiss GL, Pilhofer M
2.6-Å resolution cryo-EM structure of a class Ia ribonucleotide reductase trapped with mechanism-based inhibitor N(3)CDP.
1. bioRxiv - published October 1, 2024
2. Westmoreland DE, Feliciano PR, Kang G, Cui C, Kim A, Stubbe J, Nocera DG, Drennan CL
Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity.
1. bioRxiv - published October 1, 2024
2. Ali A, Zhang Z, Gao T, Aleksic S, Gavathiotis E, Barzilai N, Milman S
Bond-centric modular design of protein assemblies.
1. bioRxiv - published October 1, 2024
2. Wang S, Favor A, Kibler R, Lubner J, Borst AJ, Coudray N, Redler RL, Chiang HT, Sheffler W, Hsia Y, Li Z, Ekiert DC, Bhabha G, Pozzo LD, Baker D
Characterization of neural infection by Oropouche orthobunyavirus.
1. bioRxiv - published October 1, 2024
2. Connors KA, Pedlow MR, Frey ZD, McGaughey JJ, Amarasinghe GK, Duprex WP, D'Aiuto L, Wills ZP, Hartman AL
In situ crystalline structure of the human eosinophil major basic protein-1.
1. bioRxiv - published October 1, 2024
2. Yang JE, Mitchell JM, Bingman CA, Mosher DF, Wright ER
ExoSloNano: Multi-Modal Nanogold Tags for identification of Macromolecules in Live Cells & Cryo-Electron Tomograms.
1. bioRxiv - published October 1, 2024
2. Young LN, Sherrard A, Zhou H, Shaikh F, Hutchings J, Riggi M, Rosen MK, Giraldez AJ, Villa E
Association of COVID-19 risk factors with systemic fungal infections in hospitalized patients.
1. medRxiv - published October 1, 2024
2. Wilbourn AC, Tsodikov OV, Garneau-Tsodikova S
Systematic, high-throughput characterization of bacteriophage gene essentiality on diverse hosts.
1. bioRxiv - published October 1, 2024
2. Chen J, Nilsen ED, Chitboonthavisuk C, Mo CY, Raman S
An approach for coherent periodogram averaging of tilt-series data for improved CTF estimation.
1. bioRxiv - published October 1, 2024
2. Khavnekar S, Wan W
MPXV Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to MVA-BN Vaccination.
1. J Infect Dis - published October 1, 2024
2. Selverian CN, Monticelli SR, Jaleta YM, Lasso G, DeMouth ME, Meola A, Berrigan J, Batchelor TG, Battini L, Guardado-Calvo P, Herbert AS, Chandran K, Meyerowitz E, Miller EH
A flagellar accessory protein links chemotaxis to surface sensing.
1. J Bacteriol - published October 1, 2024
2. Salemi RI, Cruz AK, Hershey DM
An ILC2-chitinase circuit restores lung homeostasis after epithelial injury.
1. Sci Immunol - published October 1, 2024
2. Jung H, Kim DH, Díaz RE, White JM, Rucknagel S, Mosby L, Wang Y, Reddy S, Winkler ES, Hassan AO, Ying B, Diamond MS, Locksley RM, Fraser JS, Van Dyken SJ
A conserved fertilization complex bridges sperm and egg in vertebrates.
1. Cell - published October 1, 2024
2. Deneke VE, Blaha A, Lu Y, Suwita JP, Draper JM, Phan CS, Panser K, Schleiffer A, Jacob L, Humer T, Stejskal K, Krssakova G, Roitinger E, Handler D, Kamoshita M, Vance TDR, Wang X, Surm JM, Moran Y, Lee JE, Ikawa M, Pauli A
Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6.
1. Structure - published October 1, 2024
2. Viennet T, Yin M, Jayaraj A, Kim W, Sun ZJ, Fujiwara Y, Zhang K, Seruggia D, Seo HS, Dhe-Paganon S, Orkin SH, Arthanari H
Phosphorylation regulates the chromatin remodeler SMARCAD1 in nucleosome binding, ATP hydrolysis, and histone exchange.
1. J Biol Chem - published October 1, 2024
2. Aboulache BL, Hoitsma NM, Luger K
Comprehensive functional evaluation of head and neck squamous cell carcinoma with BH3-profiling demonstrates apoptotic competency and therapeutic efficacy of BH3-mimetics.
1. Oral Oncol - published October 1, 2024
2. Li D, Lopez A, Shrivastava N, Chan W, Thomas C, Burk R, Segall J, Augustine S, Rosenblatt G, Mehta V, Schiff BA, Smith RV, Prystowsky MB, Schlecht NF, Guha C, Gavathiotis E, Ow TJ
Binding Mode of Cyclic Chemerin-9 Peptide and ChemerinS157 Protein at CMKLR1.
1. Chembiochem - published October 1, 2024
2. Schermeng T, Liessmann F, Katharina Ambrosius C, Meiler J, Beck-Sickinger AG
The homeodomain regulates stable DNA binding of prostate cancer target ONECUT2.
1. Nat Commun - published October 1, 2024
2. Chatterjee A, Gallent B, Katiki M, Qian C, Harter MR, Silletti S, Komives EA, Freeman MR, Murali R
Qingshen granules inhibits dendritic cell glycolipid metabolism to alleviate renal fibrosis via PI3K-AKT-mTOR pathway.
1. Phytomedicine - published October 1, 2024
2. Zhou WJ, Liang W, Hu MX, Ma YK, Yu S, Jin C, Li JQ, Wang C, Wang CZ, Gong P, Wu QQ, Wu CG, Wang YP, Liu TT
Nanobodies: from high-throughput identification to therapeutic development.
1. Mol Cell Proteomics - published October 1, 2024
2. Fridy PC, Rout MP, Ketaren NE
Determination of Protein-Ligand Binding Affinities by Thermal Shift Assay.
1. ACS Pharmacol Transl Sci - published October 1, 2024
2. Khan MF, Rahman MM, Xin Y, Mustafa A, Smith BJ, Ottemann KM, Roujeinikova A
Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase.
1. iScience - published October 1, 2024
2. Gedeon A, Yab E, Dinut A, Sadowski E, Capton E, Dreneau A, Petit J, Gioia B, Piveteau C, Djaout K, Lecat E, Wehenkel AM, Gubellini F, Mechaly A, Alzari PM, Deprez B, Baulard A, Aubry A, Willand N, Petrella S
Quinoline-based compounds can inhibit diverse enzymes that act on DNA.
1. Cell Chem Biol - published October 1, 2024
2. Zhou J, Chen Q, Ren R, Yang J, Liu B, Horton JR, Chang C, Li C, Maksoud L, Yang Y, Rotili D, Jain AK, Zhang X, Blumenthal RM, Chen T, Gao Y, Valente S, Mai A, Cheng X
The Role of General Acid Catalysis in the Mechanism of an Alkyl Transferase Ribozyme.
1. ACS Catal - published October 1, 2024
2. Wilson TJ, McCarthy E, Ekesan Ş, Giese TJ, Li NS, Huang L, Piccirilli JA, York DM, Lilley DMJ
Distinct roles of size-defined HDL subpopulations in cardiovascular disease.
1. Curr Opin Lipidol - published October 1, 2024
2. Davidson WS, Vaisar T, Heinecke JW, Bornfeldt KE
Cryo-electron microscopy reveals a single domain antibody with a unique binding epitope on fibroblast activation protein alpha.
1. bioRxiv - published October 1, 2024
2. Xu Z, Sinha A, Pandya DN, Schnicker NJ, Wadas TJ
Visualizing nucleation, condensation and propagation of β-tubulin folding in chaperonin TRiC.
1. bioRxiv - published October 1, 2024
2. Zhao Y, Schmid MF, Chiu W
Mechanistic Studies of Small Molecule Ligands Selective to RNA Single G Bulges.
1. bioRxiv - published October 1, 2024
2. Hegde S, Akhter S, Tang Z, Qi C, Yu C, Lewicka A, Liu Y, Koirala K, Reibarkh M, Battaile KP, Cooper A, Lovell S, Holmstrom ED, Wang X, Piccirilli JA, Gao Q, Miao Y, Wang J
Two conserved arginine residues facilitate C-S bond cleavage and persulfide transfer in Suf family cysteine desulfurases.
1. bioRxiv - published October 1, 2024
2. Gogar RK, Conte JV, Dunkle JA, Frantom PA
Initiation of ERAD by the bifunctional complex of Mnl1 mannosidase and protein disulfide isomerase.
1. bioRxiv - published October 1, 2024
2. Zhao D, Wu X, Rapoport TA