Member Publications

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147 Member Publications for September 2024

Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.
1. PLoS One - published September 26, 2024
2. Imelio JA, Trajtenberg F, Mondino S, Zarantonelli L, Vitrenko I, Lemée L, Cokelaer T, Picardeau M, Buschiazzo A
Identification of a recessive gene RgM4G52 conferring red glume, stem, and rachis in a Triticum boeoticum mutant.
1. Front Plant Sci - published September 10, 2024
2. Chen L, Zhang J, Ma P, Miao Y, Wu L, Zhou K, Yang J, Zhang M, Liu X, Jiang B, Hao M, Huang L, Ning S, Chen X, Chen X, Liu D, Wan H, Zhang L
RBM25 is required to restrain inflammation via ACLY RNA splicing-dependent metabolism rewiring.
1. Cell Mol Immunol - published September 9, 2024
2. Zhang Y, Gao Y, Wang Y, Jiang Y, Xiang Y, Wang X, Wang Z, Ding Y, Chen H, Rui B, Huai W, Cai B, Ren X, Ma F, Xu S, Zhan Z, Liu X
Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics.
1. Nat Rev Microbiol - published September 9, 2024
2. Timm MR, Russell SK, Hultgren SJ
The Structure of Cilium Inner Junctions Revealed by Electron Cryo-tomography.
1. bioRxiv - published September 9, 2024
2. Li S, Fernandez JJ, Ruehle MD, Howard-Till RA, Fabritius A, Pearson CG, Agard DA, Winey ME
Conjugative transfer of the IncN plasmid pKM101 is mediated by dynamic interactions between the TraK accessory factor and TraI relaxase.
1. FEBS Lett - published September 8, 2024
2. Li YG, Breidenstein A, Berntsson RP, Christie PJ
Fluorescence-detection size-exclusion chromatography specifically detects autoantibodies targeting the ganglionic acetylcholine receptor in patients with autoimmune autonomic ganglionopathy.
1. J Neuroimmunol - published September 8, 2024
2. Baxter L, Hopkins S, O'Connor KC, Pham MC, Nowak RJ, Monson NL, Blackburn K, Hibbs RE, Vernino S, Noviello CM
Structural basis of the excitatory amino acid transporter 3 substrate recognition.
1. bioRxiv - published September 8, 2024
2. Qiu B, Boudker O
Molecular glues that inhibit specific Zn(2+)-dependent DUB activity and inflammation.
1. bioRxiv - published September 7, 2024
2. Chandler F, Reddy PAN, Bhutda S, Ross RL, Walden M, Walker K, Di Donato S, Cassel JA, Prakesch MA, Aman A, Datti A, Campbell LJ, Foglizzo M, Bell L, Stein DN, Ault JR, Al-Awar RS, Calabrese AN, Sicheri F, Del Galdo F, Salvino JM, Greenberg RA, Zeqiraj E
Temperature Sensitive Glutamate Gating of AMPA-subtype iGluRs.
1. bioRxiv - published September 7, 2024
2. Mondal AK, Carrillo E, Jayaraman V, Twomey EC
Short CDRL1 in intermediate VRC01-like mAbs is not sufficient to overcome key glycan barriers on HIV-1 Env.
1. J Virol - published September 6, 2024
2. Agrawal P, Knudsen ML, MacCamy A, Hurlburt NK, Khechaduri A, Salladay KR, Kher GM, Kallur Siddaramaiah L, Stuart AB, Bontjer I, Shen X, Montefiori D, Gristick HB, Bjorkman PJ, Sanders RW, Pancera M, Stamatatos L
Distinct stabilization of the human T cell leukemia virus type 1 immature Gag lattice.
1. Nat Struct Mol Biol - published September 6, 2024
2. Obr M, Percipalle M, Chernikova D, Yang H, Thader A, Pinke G, Porley D, Mansky LM, Dick RA, Schur FKM
An artificial intelligence accelerated virtual screening platform for drug discovery.
1. Nat Commun - published September 5, 2024
2. Zhou G, Rusnac DV, Park H, Canzani D, Nguyen HM, Stewart L, Bush MF, Nguyen PT, Wulff H, Yarov-Yarovoy V, Zheng N, DiMaio F
Structural and functional diversity of Resistance-Nodulation-Division (RND) efflux pump transporters with implications for antimicrobial resistance.
1. Microbiol Mol Biol Rev - published September 5, 2024
2. Kavanaugh LG, Dey D, Shafer WM, Conn GL
Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase.
1. bioRxiv - published September 5, 2024
2. Skeens E, Maschietto F, Manjula R, Shillingford S, Lolis EJ, Batista VS, Bennett AM, Lisi GP
Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A.
1. bioRxiv - published September 5, 2024
2. Khandelwal NK, Gupta M, Gomez JE, Barkho S, Guan Z, Eng AY, Kawate T, Balasubramani SG, Sali A, Hung DT, Stroud RM
Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance.
1. Viruses - published September 5, 2024
2. Azzolino VN, Shaqra AM, Ali A, Kurt Yilmaz N, Schiffer CA
Small LEA proteins mitigate air-water interface damage to fragile cryo-EM samples during plunge freezing.
1. Nat Commun - published September 4, 2024
2. Abe KM, Li G, He Q, Grant T, Lim CJ
Accurate identification of periplasmic urea-binding proteins by structure- and genome context-assisted functional analysis.
1. J Mol Biol - published September 4, 2024
2. Allert MJ, Kumar S, Wang Y, Beese LS, Hellinga HW
Structural basis of transcription: RNA polymerase II substrate binding and metal coordination using a free-electron laser.
1. Proc Natl Acad Sci U S A - published September 3, 2024
2. Lin G, Barnes CO, Weiss S, Dutagaci B, Qiu C, Feig M, Song J, Lyubimov A, Cohen AE, Kaplan CD, Calero G
An Updated Structure of Oxybutynin Hydrochloride.
1. Adv Sci (Weinh) - published September 3, 2024
2. Lin J, Bu G, Unge J, Gonen T
Structural and functional effects of phosphopriming and scaffolding in the kinase GSK-3β.
1. Sci Signal - published September 3, 2024
2. Enos MD, Gavagan M, Jameson N, Zalatan JG, Weis WI
Neu5Gc binding loss of subtype H7 influenza A virus facilitates adaptation to gallinaceous poultry following transmission from waterbirds.
1. J Virol - published September 3, 2024
2. Guan M, DeLiberto TJ, Feng A, Zhang J, Li T, Wang S, Li L, Killian ML, Praena B, Giri E, Deliberto ST, Hang J, Olivier A, Torchetti MK, Tao YJ, Parrish C, Wan X-F
Early Preclinical Studies of Ergosterol Peroxide and Biological Evaluation of Its Derivatives.
1. ACS Omega - published September 3, 2024
2. Ling T, Arroyo-Cruz LV, Smither WR, Seighman EK, Martínez-Montemayor MM, Rivas F
SARS-CoV-2 IgG seroprevalence in the Okinawa Main Island and remote islands in Okinawa, Japan, 2020-2021.
1. Jpn J Infect Dis - published September 3, 2024
2. Takayama Y, Shimakawa Y, Aizawa Y, Butcher C, Chibana N, Collins M, Kamegai K, Kim TG, Koyama S, Matsuyama R, Matthews MM, Mori T, Nagamoto T, Narita M, Omori R, Shibata N, Shibata S, Shiiki S, Takakura S, Toyozato N, Tsuchiya H, Wolf M, Yamamoto T, Yokoyama S, Yonaha S, Mizumoto K
Comprehensive Profiling of Roquin Binding Preferences for RNA Stem-Loops.
1. Angew Chem Int Ed Engl - published September 3, 2024
2. Oberstrass L, Tants JN, Lichtenthaeler C, Ali SE, Koch L, Mathews DH, Schlundt A, Weigand J
Supramolecular Architectures of Dendritic Polymers Provide Irreversible Inhibitor to Block Viral Infection.
1. Adv Mater - published September 3, 2024
2. Mohammadifar E, Gasbarri M, Dimde M, Nie C, Wang H, Povolotsky TL, Kerkhoff Y, Desmecht D, Prevost S, Zemb T, Ludwig K, Stellacci F, Haag R
On the function of TRAP substrate-binding proteins: conformational variation of the sialic acid binding protein SiaP.
1. J Biol Chem - published September 3, 2024
2. King-Hudson TJ, Davies JS, Quan S, Currie MJ, Tillett ZD, Copping J, Panjikar S, Friemann R, Allison JR, North RA, Dobson RCJ
Transcription of HIV-1 at sites of intact latent provirus integration.
1. J Exp Med - published September 2, 2024
2. Teixeira AR, Bittar C, Silva Santos GS, Oliveira TY, Huang AS, Linden N, Ferreira IATM, Murdza T, Muecksch F, Jones RB, Caskey M, Jankovic M, Nussenzweig MC
The synaptonemal complex aligns meiotic chromosomes by wetting.
1. bioRxiv - published September 2, 2024
2. Gordon SG, Rodriguez AA, Gu Y, Corbett KD, Lee CF, Rog O
Distinct binding conformations of epinephrine with α- and β-adrenergic receptors.
1. Exp Mol Med - published September 2, 2024
2. Lou JS, Su M, Wang J, Do HN, Miao Y, Huang XY
A structural decryption of cryptochromes.
1. Front Chem - published September 2, 2024
2. DeOliveira CC, Crane BR
The yin and yang of the universal transcription factor NusG.
1. Curr Opin Microbiol - published September 2, 2024
2. Delbeau M, Froom R, Landick R, Darst SA, Campbell EA
Crossing the membrane - what does it take to flip a phospholipid? Structural and biochemical advances on P4-ATPase flippases.
1. J Biol Chem - published September 2, 2024
2. Sai KV, Lee JY
Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity.
1. Cell - published September 2, 2024
2. Fontana P, Du G, Zhang Y, Zhang H, Vora SM, Hu JJ, Shi M, Tufan AB, Healy LB, Xia S, Lee DJ, Li Z, Baldominos P, Ru H, Luo HR, Agudo J, Lieberman J, Wu H
Lipids from a snail host regulate the multicellular behavior of a predator of parasitic schistosomes.
1. iScience - published September 2, 2024
2. Kidner RQ, Goldstone EB, Laidemitt MR, Sanchez MC, Gerdt C, Brokaw LP, Ros-Rocher N, Morris J, Davidson WS, Gerdt JP
Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs.
1. bioRxiv - published September 2, 2024
2. Carroll EC, Yang H, Jones JG, Oehler A, Charvat AF, Montgomery KM, Yung A, Millbern Z, Vinueza NR, DeGrado WF, Mordes DA, Condello C, Gestwicki JE
Conformational ensembles in Klebsiella pneumoniae FimH impact uropathogenesis.
1. Proc Natl Acad Sci U S A - published September 2, 2024
2. Lopatto EDB, Pinkner JS, Sanick DA, Potter RF, Liu LX, Bazán Villicaña J, Tamadonfar KO, Ye Y, Zimmerman MI, Gualberto NC, Dodson KW, Janetka JW, Hunstad DA, Hultgren SJ
Large library docking identifies positive allosteric modulators of the calcium-sensing receptor.
1. Science - published September 2, 2024
2. Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G
Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway.
1. Sci Adv - published September 2, 2024
2. Xiao L, Pi X, Goss AC, El-Baba T, Ehrmann JF, Grinkevich E, Bazua-Valenti S, Padovano V, Alper SL, Carey D, Udeshi ND, Carr SA, Pablo JL, Robinson CV, Greka A, Wu H
Cryo-EM structures of the Spo11 core complex bound to DNA.
1. Nat Struct Mol Biol - published September 2, 2024
2. Yu Y, Wang J, Liu K, Zheng Z, Arter M, Claeys Bouuaert C, Pu S, Patel DJ, Keeney S
Author Correction: Drosophila immune cells transport oxygen through PPO2 protein phase transition.
1. Nature - published September 2, 2024
2. Shin M, Chang E, Lee D, Kim N, Cho B, Cha N, Koranteng F, Song JJ, Shim J
A genus-specific nsp12 region impacts polymerase assembly in Alpha- and Gammacoronaviruses.
1. J Biol Chem - published September 2, 2024
2. Hoferle PJ, Anderson TK, Kirchdoerfer RN
Discovery of AK-1690: A Potent and Highly Selective STAT6 PROTAC Degrader.
1. J Med Chem - published September 2, 2024
2. Kaneshige A, Yang Y, Bai L, Wang M, Xu R, Mallik L, Chinnaswamy K, Metwally H, Wang Y, McEachern D, Tošović J, Yang CY, Kirchhoff PD, Meagher JL, Stuckey JA, Wang S
Chemical and topological design of multicapped mRNA and capped circular RNA to augment translation.
1. Nat Biotechnol - published September 2, 2024
2. Chen H, Liu D, Aditham A, Guo J, Huang J, Kostas F, Maher K, Friedrich MJ, Xavier RJ, Zhang F, Wang X
Silybin: A Review of Its Targeted and Novel Agents for Treating Liver Diseases Based on Pathogenesis.
1. Phytother Res - published September 2, 2024
2. Wu J, Wen L, Liu X, Li Q, Sun Z, Liang C, Xie F, Li X
Chemical tools for probing the Ub/Ubl conjugation cascades.
1. Chembiochem - published September 2, 2024
2. Kochanczyk T, Fishman M, Lima CD
The Next Twenty Years of the Journal of Chemical Theory and Computation.
1. J Chem Theory Comput - published September 2, 2024
2. Cui Q, De Vivo M, Gagliardi L
Author Correction: PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation.
1. EMBO J - published September 2, 2024
2. Kar P, Chatrin C, Đukić N, Suyari O, Schuller M, Zhu K, Prokhorova E, Bigot N, Baretić D, Ahel J, Elsborg JD, Nielsen ML, Clausen T, Huet S, Niepel M, Sanyal S, Ahel D, Smith R, Ahel I
Partial closure of the γ-tubulin ring complex by CDK5RAP2 activates microtubule nucleation.
1. Dev Cell - published September 2, 2024
2. Xu Y, Muñoz-Hernández H, Krutyhołowa R, Marxer F, Cetin F, Wieczorek M
Increasing intracellular dNTP levels improves prime editing efficiency.
1. Nat Biotechnol - published September 2, 2024
2. Liu P, Ponnienselvan K, Nyalile T, Oikemus S, Joynt AT, Iyer S, Kelly K, Guo D, Kyawe PP, Vanderleeden E, Redick SD, Huang L, Chen Z, Lee JM, Schiffer CA, Harlan DM, Wang JP, Emerson CP Jr, Lawson ND, Watts JK, Sontheimer EJ, Luban J, Wolfe SA
Reduction of prolonged excitatory neuron swelling after spinal cord injury improves locomotor recovery in mice.
1. Sci Transl Med - published September 2, 2024
2. Li Q, Sandoval A, Moth J, Shang J, Liew JY, Dunn T, Yang Z, Su J, Henwood M, Williams P, Chen B
Structure-guided in vitro evolution of nanobodies targeting new viral variants.
1. PLoS Pathog - published September 2, 2024
2. Ye G, Bu F, Pan R, Mendoza A, Yang G, Spiller B, Wadzinski BE, Du L, Perlman S, Liu B, Li F
Artificial targeting of the NEIL1 DNA glycosylase to the mitochondria.
1. Environ Mol Mutagen - published September 2, 2024
2. Thompson MK, Eggers MH, Benton RG, Johnsten T, Prakash A
Structure-Based Design of CBP/EP300 Degraders: When Cooperativity Overcomes Affinity.
1. JACS Au - published September 2, 2024
2. Cheng-Sánchez I, Gosselé K, Palaferri L, Laul E, Riccabella G, Bedi RK, Li Y, Müller A, Corbeski I, Caflisch A, Nevado C
A Method for Treating Significant Conformational Changes in Alchemical Free Energy Simulations of Protein-Ligand Binding.
1. J Chem Theory Comput - published September 2, 2024
2. Liao J, Sergeeva AP, Harder ED, Wang L, Sampson JM, Honig B, Friesner RA
Bifunctional Hexadentate Pyclen-based Chelating Agent for Mild Radiofluorination in Aqueous Solution at Room Temperature with a Ga-18F Ternary Complex.
1. Chemistry - published September 2, 2024
2. Dioury F, San C, Gnanalingam G, Henoumont C, Haouz A, Shepard W, Rousselin Y, Vijayakumar K, Hosten B, Laurent S, Port M
Differential responses in the core, active site and peripheral regions of cytochrome c peroxidase to extreme pressure and temperature.
1. J Mol Biol - published September 2, 2024
2. Zawistowski RK, Crane BR
Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues.
1. Eur J Med Chem - published September 2, 2024
2. Hassan MM, Li YD, Ma MW, Teng M, Byun WS, Puvar K, Lumpkin R, Sandoval B, Rutter JC, Jin CY, Wang MY, Xu S, Schmoker AM, Cheong H, Groendyke BJ, Qi J, Fischer ES, Ebert BL, Gray NS
A human-serum-free medium can induce more infectious P. falciparum gametocytes than a conventional human-serum-containing medium.
1. Sci Rep - published September 2, 2024
2. Miura K, Deng B, Varadharajan Suresh R, Gebremicale YT, Zhou L, Pham TP, Roche K, Diouf A, Lovell JF, Julien JP, Long CA
Production of hybrid macrolide antibiotics by exploiting the specific substrate recognition characteristics of multifunctional cytochrome P450 enzyme MycG.
1. FEMS Microbiol Lett - published September 2, 2024
2. Iizaka Y, Yamada M, Koshino S, Takahashi S, Saito R, Sherman DH, Anzai Y
Enriched G4 forming repeats in the human genome are associated with robust well-coordinated transcription and reduced cancer transcriptome variation.
1. J Biol Chem - published September 2, 2024
2. De-Paula RB, Bacolla A, Syed A, Tainer JA
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation.
1. Cell Chem Biol - published September 2, 2024
2. Mutlu B, Sharabi K, Sohn JH, Yuan B, Latorre-Muro P, Qin X, Yook JS, Lin H, Yu D, Camporez JPG, Kajimura S, Shulman GI, Hui S, Kamenecka TM, Griffin PR, Puigserver P
Unraveling MLL1-fusion Leukemia: Epigenetic Revelations from an iPS Cell Point Mutation.
1. J Biol Chem - published September 2, 2024
2. Kobrossy L, Xu W, Zhang C, Feng W, Turner CE, Cosgrove MS
Selective Transfection of a Transferrin Receptor-Expressing Cell Line with DNA-Lipid Nanoparticles.
1. ACS Omega - published September 2, 2024
2. Vinales I, Silva-Espinoza JC, Medina BA, Urbay JEM, Beltran MA, Salinas DE, Ramirez-Ramos MA, Maldonado RA, Poon W, Penichet ML, Almeida IC, Michael K
A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development.
1. bioRxiv - published September 2, 2024
2. Fan AT, Gadbois GE, Huang HT, Jiang J, Sigua LH, Smith ER, Wu S, Dunne-Dombrink K, Goyal P, Tao AJ, Sellers W, Fischer ES, Donovan KA, Ferguson FM
Allosteric mechanism of membrane fusion activation in a herpesvirus.
1. bioRxiv - published September 2, 2024
2. González-Del Pino GL, Walsh RM Jr, Atanasiu D, Cairns TM, Saw WT, Cohen GH, Heldwein EE
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.
1. Neuron - published September 2, 2024
2. Carling GK, Fan L, Foxe NR, Norman K, Wong MY, Zhu D, Corona C, Razzoli A, Yu F, Yarahmady A, Ye P, Chen H, Huang Y, Amin S, Sereda R, Lopez-Lee C, Zacharioudakis E, Chen X, Xu J, Cheng F, Gavathiotis E, Cuervo AM, Holtzman DM, Mok SA, Sinha SC, Sidoli S, Ratan RR, Luo W, Gong S, Gan L
A simple benzothiazolium-based sensor for cyanide detection: Applications in environmental analysis and bioimaging.
1. Spectrochim Acta A Mol Biomol Spectrosc - published September 2, 2024
2. Uota S, Hwang BJ, Butcher R, Mullins R, Wachira J, Hijji Y, Abebe F
Discovery of electrophilic degraders that exploit S(N)Ar chemistry.
1. bioRxiv - published September 2, 2024
2. Zhuang Z, Byun WS, Kozicka Z, Dwyer BG, Donovan KA, Jiang Z, Jones HM, Abeja DM, Nix MN, Zhong J, Słabicki M, Fischer ES, Ebert BL, Gray NS
Flagellar switch inverted repeat impacts flagellar invertibility and varies Clostridioides difficile RT027/MLST1 virulence.
1. bioRxiv - published September 2, 2024
2. Nhu NTQ, Lin H, Pigli Y, Sia JK, Kuhn P, Snitkin ES, Young V, Kamboj M, Pamer EG, Rice PA, Shen A, Dong Q
Expanding Automated Multiconformer Ligand Modeling to Macrocycles and Fragments.
1. bioRxiv - published September 2, 2024
2. Flowers J, Echols N, Correy G, Jaishankar P, Togo T, Renslo AR, van den Bedem H, Fraser JS, Wankowicz SA
A one-step protocol to generate impermeable fluorescent HaloTag substrates for in situ live cell application and super-resolution imaging.
1. bioRxiv - published September 2, 2024
2. Roßmann K, Sun S, Olesen CH, Kowald M, Tapp E, Pabst U, Bieck M, Birke R, Shields BC, Jeong P, Hong J, Tadross MR, Levitz J, Lehmann M, Lipstein N, Broichhagen J
Structural Basis for Antibody Neutralization of Pertussis Toxin.
1. bioRxiv - published September 2, 2024
2. Goldsmith JA, Nguyen AW, Wilen RE, Wijagkanalan W, McLellan JS, Maynard JA
Endo-IP and Lyso-IP Toolkit for Endolysosomal Profiling of Human Induced Neurons.
1. bioRxiv - published September 2, 2024
2. Hundley FV, Gonzalez-Lozano MA, Gottschalk LM, Cook ANK, Zhang J, Paulo JA, Harper JW
CLCC1 promotes membrane fusion during herpesvirus nuclear egress.
1. bioRxiv - published September 2, 2024
2. Dai B, Polack L, Sperl A, Dame H, Huynh T, Deveney C, Lee C, Doench JG, Heldwein EE
Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma.
1. bioRxiv - published September 2, 2024
2. Kader T, Lin JR, Hug C, Coy S, Chen YA, de Bruijn I, Shih N, Jung E, Pelletier RJ, Leon ML, Mingo G, Omran DK, Lee JS, Yapp C, Satravada BA, Kundra R, Xu Y, Chan S, Tefft JB, Muhlich J, Kim S, Gysler SM, Agudo J, Heath JR, Schultz N, Drescher C, Sorger PK, Drapkin R, Santagata S
Directed evolution of an orthogonal transcription engine for programmable gene expression in eukaryotes.
1. bioRxiv - published September 2, 2024
2. Kar S, Gardner EC, Javanmardi K, Boutz DR, Shroff R, Horton AP, Segall-Shapiro TH, Ellington AD, Gollihar J
Reposition: Focalizing β-Alanine Metabolism and the Anti-Inflammatory Effects of Its Metabolite Based on Multi-Omics Datasets.
1. Int J Mol Sci - published September 2, 2024
2. Luo W, Zhang H, Zhang H, Xu Y, Liu X, Xu S, Wang P
Genome Instability Induced by Topoisomerase Misfunction.
1. Int J Mol Sci - published September 2, 2024
2. Nitiss KC, Bandak A, Berger JM, Nitiss JL
Targeted knock-in of NCF1 cDNA into the NCF2 locus leads to myeloid phenotypic correction of p47 (phox) -deficient chronic granulomatous disease.
1. Mol Ther Nucleic Acids - published September 1, 2024
2. Siow KM, Güngör M, Wrona D, Raimondi F, Pastukhov O, Tsapogas P, Menzi T, Schmitz M, Kulcsár PI, Schwank G, Schulz A, Jinek M, Modlich U, Siler U, Reichenbach J
Identification of potential candidate miRNAs related to semen quality in seminal plasma extracellular vesicles and sperms of male duck (Anas Platyrhynchos).
1. Poult Sci - published September 1, 2024
2. Luo X, Huang L, Guo Y, Yang Y, Gong P, Ye S, Wang L, Feng Y
In situ serial crystallography facilitates 96-well plate structural analysis at low symmetry.
1. IUCrJ - published September 1, 2024
2. Foos N, Florial JB, Eymery M, Sinoir J, Felisaz F, Oscarsson M, Beteva A, Bowler MW, Nurizzo D, Papp G, Soler-Lopez M, Nanao M, Basu S, McCarthy AA
DARPin-fused T cell engager for adenovirus-mediated cancer therapy.
1. Mol Ther Oncol - published September 1, 2024
2. Freitag PC, Kolibius J, Wieboldt R, Weber R, Hartmann KP, van Gogh M, Brücher D, Läubli H, Plückthun A
Structures of Brucella ovis leucine-, isoleucine-, valine-, threonine- and alanine-binding protein reveal a conformationally flexible peptide-binding cavity.
1. Acta Crystallogr F Struct Biol Commun - published September 1, 2024
2. Chakafana G, Boswell R, Chandler A, Jackson KA, Neblett S, Postal T, Subramanian S, Abendroth J, Myler PJ, Asojo OA
Solvent organization in the ultrahigh-resolution crystal structure of crambin at room temperature.
1. IUCrJ - published September 1, 2024
2. Chen JCH, Gilski M, Chang C, Borek D, Rosenbaum G, Lavens A, Otwinowski Z, Kubicki M, Dauter Z, Jaskolski M, Joachimiak A
Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation.
1. Proc Natl Acad Sci U S A - published September 1, 2024
2. Sponholtz MR, Byrne PO, Lee AG, Ramamohan AR, Goldsmith JA, McCool RS, Zhou L, Johnson NV, Hsieh CL, Connors M, Karthigeyan KP, Crooks CM, Fuller AS, Campbell JD, Permar SR, Maynard JA, Yu D, Bottomley MJ, McLellan JS
Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α.
1. Proc Natl Acad Sci U S A - published September 1, 2024
2. He W, Gasmi-Seabrook GMC, Ikura M, Lee JE, Ohh M
The C-terminus of CFAP410 forms a tetrameric helical bundle that is essential for its localization to the basal body.
1. Open Biol - published September 1, 2024
2. Stadler A, De Liz LV, Gabriel HB, Alonso-Gil S, Crickley R, Korbula K, Žagrović B, Vaughan S, Sunter JD, Dong G
Organoid culture promotes dedifferentiation of mouse myoblasts into stem cells capable of complete muscle regeneration.
1. Nat Biotechnol - published September 1, 2024
2. Price FD, Matyas MN, Gehrke AR, Chen W, Wolin EA, Holton KM, Gibbs RM, Lee A, Singu PS, Sakakeeny JS, Poteracki JM, Goune K, Pfeiffer IT, Boswell SA, Sorger PK, Srivastava M, Pfaff KL, Gussoni E, Buchanan SM, Rubin LL
HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration.
1. Nucleic Acids Res - published September 1, 2024
2. Jang S, Bedwell GJ, Singh SP, Yu HJ, Arnarson B, Singh PK, Radhakrishnan R, Douglas AW, Ingram ZM, Freniere C, Akkermans O, Sarafianos SG, Ambrose Z, Xiong Y, Anekal PV, Montero Llopis P, KewalRamani VN, Francis AC, Engelman AN
Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models.
1. Sci Transl Med - published September 1, 2024
2. Dejoux A, Zhu Q, Ganneau C, Goff OR, Godon O, Lemaitre J, Relouzat F, Huetz F, Sokal A, Vandenberghe A, Pecalvel C, Hunault L, Derenne T, Gillis CM, Iannascoli B, Wang Y, Rose T, Mertens C, Nicaise-Roland P, NASA Study Group, England P, Mahévas M, de Chaisemartin L, Le Grand R, Letscher H, Saul F, Pissis C, Haouz A, Reber LL, Chappert P, Jönsson F, Ebo DG, Millot GA, Bay S, Chollet-Martin S, Gouel-Chéron A, Bruhns P
Substrate dependence of transport coupling and phenotype of a small multidrug resistance transporter in Pseudomonas aeruginosa.
1. J Bacteriol - published September 1, 2024
2. Wegrzynowicz AK, Heelan WJ, Demas SP, McLean MS, Peters JM, Henzler-Wildman KA
Restoration of LAMP2A expression in old mice leads to changes in the T cell compartment that support improved immune function.
1. Proc Natl Acad Sci U S A - published September 1, 2024
2. Reynolds CA, Pelka S, Gjergjova F, Tasset I, Khawaja RR, Lindenau K, Krause GJ, Gavathiotis E, Cuervo AM, Macian F
C1ql1 expression in oligodendrocyte progenitor cells promotes oligodendrocyte differentiation.
1. FEBS J - published September 1, 2024
2. Altunay ZM, Biswas J, Cheung HW, Pijewski RS, Papile LE, Akinlaja YO, Tang A, Kresic LC, Schouw AD, Ugrak MV, Caro K, Peña Palomino PA, Ressl S, Nishiyama A, Crocker SJ, Martinelli DC
The prolyl isomerase FKBP11 is a secretory translocon accessory factor.
1. Mol Biol Cell - published September 1, 2024
2. DiGuilio A, Cheng B, Zhong F, Jha R, Wan Y, Anghel A, Hu H, Shishkova E, Ji Z, Coon JJ, Keenan RJ
DNA Replication across α-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase η.
1. Biochemistry - published September 1, 2024
2. Tomar R, Ghodke PP, Patra A, Smyth E, Pontarelli A, Copp W, Guengerich FP, Chaput JJ, Wilds CJ, Stone MP, Egli M
Sec18 side-loading is essential for universal SNARE recycling across cellular contexts.
1. bioRxiv - published September 1, 2024
2. Khan YA, Ian White K, Pfuetzner RA, Singal B, Esquivies L, Mckenzie G, Liu F, DeLong K, Choi UB, Montabana E, Mclaughlin T, Wickner WT, Brunger AT
Antibody sequence determinants of viral antigen specificity.
1. mBio - published September 1, 2024
2. Abu-Shmais AA, Vukovich MJ, Wasdin PT, Suresh YP, Marinov TM, Rush SA, Gillespie RA, Sankhala RS, Choe M, Joyce MG, Kanekiyo M, McLellan JS, Georgiev IS
Structural and Functional Characterization of a Novel Class A Flavin Monooxygenase from Bacillus niacini.
1. Biochemistry - published September 1, 2024
2. Richardson BC, Turlington ZR, Vaz Ferreira de Macedo S, Phillips SK, Perry K, Brancato SG, Cooke EW, Gwilt JR, Dasovich MA, Roering AJ, Rossi FM, Snider MJ, French JB, Hicks KA
Chemiosmotic nutrient transport in synthetic cells powered by electrogenic antiport coupled to decarboxylation.
1. Nat Commun - published September 1, 2024
2. Patiño-Ruiz MF, Anshari ZR, Gaastra B, Slotboom DJ, Poolman B
Characterization of bi-segmented and tri-segmented recombinant Pichinde virus particles.
1. J Virol - published September 1, 2024
2. Murphy H, Huang Q, Jensen J, Weber N, Mendonça L, Ly H, Liang Y
Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP.
1. Nat Commun - published September 1, 2024
2. Nadel CM, Pokhrel S, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE
Determination of Initial Rates of Lipopolysaccharide Transport.
1. Biochemistry - published September 1, 2024
2. Nava M, Rowe SJ, Taylor RJ, Kahne D, Nocera DG
Editorial: Modern approaches in cytoskeleton-related topics.
1. Curr Opin Cell Biol - published September 1, 2024
2. Janke C, Medalia O
A pleiotropic recurrent dominant ITPR3 variant causes a complex multisystemic disease.
1. Sci Adv - published September 1, 2024
2. Molitor A, Lederle A, Radosavljevic M, Sapuru V, Zavorka Thomas ME, Yang J, Shirin M, Collin-Bund V, Jerabkova-Roda K, Miao Z, Bernard A, Rolli V, Grenot P, Castro CN, Rosenzwajg M, Lewis EG, Person R, Esperón-Moldes US, Kaare M, Nokelainen PT, Batzir NA, Hoffer GZ, Paul N, Stemmelen T, Naegely L, Hanauer A, Bibi-Triki S, Grün S, Jung S, Busnelli I, Tripolszki K, Al-Ali R, Ordonez N, Bauer P, Song E, Zajo K, Partida-Sanchez S, Robledo-Avila F, Kumanovics A, Louzoun Y, Hirschler A, Pichot A, Toker O, Mejía CAM, Parvaneh N, Knapp E, Hersh JH, Kenney H, Delmonte OM, Notarangelo LD, Goetz JG, Kahwash SB, Carapito C, Bajwa RPS, Thomas C, Ehl S, Isidor B, Carapito R, Abraham RS, Hite RK, Marcus N, Bertoli-Avella A, Bahram S
Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.
1. Elife - published September 1, 2024
2. Estevam GO, Linossi EM, Macdonald CB, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS
Small-molecule properties define partitioning into biomolecular condensates.
1. Nat Chem - published September 1, 2024
2. Ambadi Thody S, Clements HD, Baniasadi H, Lyon AS, Sigman MS, Rosen MK
Three classes of propofol binding sites on GABA(A) receptors.
1. J Biol Chem - published September 1, 2024
2. Chen ZW, Chintala SM, Bracamontes J, Sugasawa Y, Pierce SR, Varga BR, Smith EH, Edge CJ, Franks NP, Cheng WWL, Akk G, Evers AS
Identification of a Polypeptide Inhibitor of O-GlcNAc Transferase with Picomolar Affinity.
1. J Am Chem Soc - published September 1, 2024
2. Hammel FA, Payne NC, Marando VM, Mazitschek R, Walker S
A single diiron enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile.
1. Nat Chem - published September 1, 2024
2. Adak S, Ye N, Calderone LA, Duan M, Lubeck W, Schäfer RJB, Lukowski AL, Houk KN, Pandelia ME, Drennan CL, Moore BS
Mint/X11 PDZ domains from non-bilaterian animals recognize and bind Ca(V)2 calcium channel C-termini in vitro.
1. Sci Rep - published September 1, 2024
2. Harracksingh AN, Singh A, Mayorova TD, Bejoy B, Hornbeck J, Elkhatib W, McEdwards G, Gauberg J, Taha A, Islam IM, Erclik T, Currie MA, Noyes M, Senatore A
Cryo-EM structure of the CBC-ALYREF complex.
1. Elife - published September 1, 2024
2. Clarke BP, Angelos AE, Mei M, Hill PS, Xie Y, Ren Y
Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96.
1. ACS Chem Biol - published September 1, 2024
2. Mahran R, Kapp JN, Valtonen S, Champagne A, Ning J, Gillette W, Stephen AG, Hao F, Plückthun A, Härmä H, Pantsar T, Kopra K
Vinyl Ether Maleic Acid Polymers: Tunable Polymers for Self-Assembled Lipid Nanodiscs and Environments for Membrane Proteins.
1. Biomacromolecules - published September 1, 2024
2. Shah MZ, Rotich NC, Okorafor EA, Oestreicher Z, Demidovich G, Eapen J, Henoch Q, Kilbey J, Prempeh G, Bates A, Page RC, Lorigan GA, Konkolewicz D
Dynamic allostery drives autocrine and paracrine TGF-β signaling.
1. Cell - published September 1, 2024
2. Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
Silencing the transcriptionally active HIV reservoir to improve treatment outcomes.
1. Nat Microbiol - published September 1, 2024
2. Prigann J, Tavora R, Furler O'Brien RL, Schulze-Gahmen U, Boehm D, Roan NR, Nixon DF, Ndhlovu LC, Valente S, Ott M
Regulation of immune responses to food by commensal microbes.
1. Immunol Rev - published September 1, 2024
2. Light SH, Nagler CR
Intracellular lipid droplets are exploited by Junín virus: a nucleoprotein-dependent process.
1. J Cell Sci - published September 1, 2024
2. Vazquez CA, Escudero-Pérez B, Hayashi JM, Leon KE, Moreira JP, Cataña MAC, Groseth A, Ott M, Oestereich L, Muñoz-Fontela C, Garcia CC, Cordo SM
Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation.
1. Nat Chem - published September 1, 2024
2. Morishita Y, Ma S, De La Mora E, Li H, Chen H, Ji X, Usclat A, Amara P, Sugiyama R, Tooh YW, Gunawan G, Pérard J, Nicolet Y, Zhang Q, Morinaka BI
Cell envelope diversity and evolution across the bacterial tree of life.
1. Nat Microbiol - published September 1, 2024
2. Hashimi A, Tocheva EI
Isolation and characterization of IgG3 glycan-targeting antibodies with exceptional cross-reactivity for diverse viral families.
1. PLoS Pathog - published September 1, 2024
2. Vukovich MJ, Shiakolas AR, Lindenberger J, Richardson RA, Bass LE, Barr M, Liu Y, Go EP, Park CS, May AJ, Sammour S, Kambarami C, Huang X, Janowska K, Edwards RJ, Mansouri K, Spence TN, Abu-Shmais AA, Manamela NP, Richardson SI, Leonard SEW, Gripenstraw KR, Setliff I, Saunders KO, Bonami RH, Ross TM, Desaire H, Moore PL, Parks R, Haynes BF, Sheward DJ, Acharya P, Sautto GA, Georgiev IS
Intracellular Ebola virus nucleocapsid assembly revealed by in situ cryo-electron tomography.
1. Cell - published September 1, 2024
2. Watanabe R, Zyla D, Parekh D, Hong C, Jones Y, Schendel SL, Wan W, Castillon G, Saphire EO
PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.
1. Nat Commun - published September 1, 2024
2. Thon O, Wang Z, Schmidpeter PAM, Nimigean CM
Activation of parkin by a molecular glue.
1. Nat Commun - published September 1, 2024
2. Sauvé V, Stefan E, Croteau N, Goiran T, Fakih R, Bansal N, Hadzipasic A, Fang J, Murugan P, Chen S, Fon EA, Hirst WD, Silvian LF, Trempe JF, Gehring K
Jiawei Xionggui Decoction promotes meningeal lymphatic vessels clearance of β-amyloid by inhibiting arachidonic acid pathway.
1. Phytomedicine - published September 1, 2024
2. Liu X, Zhang H, Xiang J, Luo W, Zhang H, Wang P, Xu S
Purified CDT toxins and a clean deletion within the CDT locus provide novel insights into the contribution of binary toxin in cellular inflammation and Clostridioides difficile infection.
1. PLoS Pathog - published September 1, 2024
2. Nabukhotna K, Kordus SL, Shupe JA, Cano Rodríguez R, Smith A, Bohannon JK, Washington MK, Lacy DB
Photomorphogenesis of Myxococcus macrosporus: new insights for light-regulation of cell development.
1. Photochem Photobiol Sci - published September 1, 2024
2. Graniczkowska KB, Bizhga D, Noda M, Leon V, Saraf N, Feliz D, Sharma G, Nugent AC, Singer M, Stojković EA
Activation of automethylated PRC2 by dimerization on chromatin.
1. Mol Cell - published September 1, 2024
2. Sauer PV, Pavlenko E, Cookis T, Zirden LC, Renn J, Singhal A, Hunold P, Hoehne-Wiechmann MN, van Ray O, Kaschani F, Kaiser M, Hänsel-Hertsch R, Sanbonmatsu KY, Nogales E, Poepsel S
Inhibition of influenza virus infection in mice by pulmonary administration of a spray dried antiviral.
1. Eur J Pharm Biopharm - published September 1, 2024
2. Heida R, Jacob Silva PH, Akkerman R, Moser J, de Vries-Idema J, Bornet A, Pawar S, Stellacci F, Frijlink HW, Huckriede ALW, Hinrichs WLJ
Development of a high throughput cytochrome P450-ligand binding assay.
1. J Biol Chem - published September 1, 2024
2. Frydendall E, Scott EE
Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics.
1. bioRxiv - published September 1, 2024
2. Baek K, Metivier RJ, Roy Burman SS, Bushman JW, Lumpkin RJ, Abeja DM, Lakshminarayan M, Yue H, Ojeda S, Verano AL, Gray NS, Donovan KA, Fischer ES
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands.
1. Res Sq - published September 1, 2024
2. Greven JA, Wydra JR, Greer RA, Zhi C, Camitta C, Song Y, Alexander-Brett JM, Brett TJ
Symmetry of loop extrusion by dimeric SMC complexes is DNA-tension-dependent.
1. bioRxiv - published September 1, 2024
2. Pradhan B, Pinto A, Kanno T, Tetiker D, Baaske MD, Cutt E, Chatzicharlampous C, Schüler H, Deep A, Corbett KD, Aragon L, Virnau P, Björkegren C, Kim E
Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing center.
1. bioRxiv - published September 1, 2024
2. Wang J, Wu M, Magupalli VG, Dahlberg PD, Wu H, Jensen GJ
Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors.
1. Structure - published September 1, 2024
2. Miyashita Y, Moriya T, Kato T, Kawasaki M, Yasuda S, Adachi N, Suzuki K, Ogasawara S, Saito T, Senda T, Murata T
Discovery and characterization of a pan-betacoronavirus S2-binding antibody.
1. Structure - published September 1, 2024
2. Johnson NV, Wall SC, Kramer KJ, Holt CM, Periasamy S, Richardson SI, Manamela NP, Suryadevara N, Andreano E, Paciello I, Pierleoni G, Piccini G, Huang Y, Ge P, Allen JD, Uno N, Shiakolas AR, Pilewski KA, Nargi RS, Sutton RE, Abu-Shmais AA, Parks R, Haynes BF, Carnahan RH, Crowe JE Jr, Montomoli E, Rappuoli R, Bukreyev A, Ross TM, Sautto GA, McLellan JS, Georgiev IS
Saturation mutagenesis-reinforced functional assays for disease-related genes.
1. Cell - published September 1, 2024
2. Ma K, Huang S, Ng KK, Lake NJ, Joseph S, Xu J, Lek A, Ge L, Woodman KG, Koczwara KE, Cohen J, Ho V, O'Connor CL, Brindley MA, Campbell KP, Lek M
Myrtus communis L. Essential Oil Exhibits Antiviral Activity against Coronaviruses.
1. Pharmaceuticals (Basel) - published September 1, 2024
2. Li DY, Donadu MG, Shue T, Dangas G, Athanasiadis A, Lan S, Wen X, Battah B, Zanetti S, Mazzarello V, Sarafianos SG, Ferrari M, Michailidis E
Real-space heterogeneous reconstruction, refinement, and disentanglement of CryoEM conformational states with HetSIREN.
1. bioRxiv - published September 1, 2024
2. Herreros D, Mata CP, Noddings C, Irene D, Krieger J, Agard DA, Tsai MD, Sorzano COS, Carazo JM
Strand dependent bypass of DNA lesions during fork reversal by ATP-dependent translocases SMARCAL1, ZRANB3, and HLTF.
1. bioRxiv - published September 1, 2024
2. Adolph MB, Warren GM, Couch FB, Greer BH, Eichman BF, Cortez D
MicroED Structures of Fluticasone Furoate and Fluticasone Propionate Provide New Insights to Their Function.
1. bioRxiv - published September 1, 2024
2. Lin J, Unge J, Gonen T
High-Resolution Cryo-EM Structure Determination of α-synuclein - A Prototypical Amyloid Fibril.
1. bioRxiv - published September 1, 2024
2. Sanchez JC, Pierson J, Borcik CG, Rienstra CM, Wright ER
The mechanism of peptidoglycan O-acetylation in Gram-negative bacteria typifies bacterial MBOAT-SGNH acyltransferases.
1. bioRxiv - published September 1, 2024
2. Anderson AC, Schultz BJ, Snow ED, Brott AS, Stangherlin S, Malloch T, London JR, Walker S, Clarke AJ
Design and immunogenicity of an HIV-1 clade C pediatric envelope glycoprotein stabilized by multiple platforms.
1. bioRxiv - published September 1, 2024
2. Kumar S, Del Moral-Sánchez I, Singh S, Newby ML, Allen JD, Bijl TPL, Vaghani Y, Jing L, Ortlund EA, Crispin M, Patel A, Sanders RW, Luthra K
Ejectosome of Pectobacterium bacteriophage ΦM1.
1. PNAS Nexus - published September 1, 2024
2. Eruera AR, Hodgkinson-Bean J, Rutter GL, Hills FR, Kumaran R, Crowe AJM, Jadav N, Chang F, McJarrow-Keller K, Jorge F, Hyun J, Kim H, Ryu B, Bostina M
Prodrug nanotherapy demonstrates in vivo anticryptosporidial efficacy in a mouse model of chronic Cryptosporidium infection.
1. RSC Pharm - published September 1, 2024
2. Ranjan AP, Czyzyk DJ, Martinez-Traverso G, Sadiqova A, Valhondo M, Schaefer DA, Spasov KA, Jorgensen WL, Vishwanatha JK, Riggs MW, Castellanos-Gonzalez A, Anderson KS