Member Publications
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162 Member Publications for July 2024
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Nematocida displodere mechanosensitive ion channel of small conductance 2 assembles into a unique 6-channel super-structure in vitro.
- PLoS One - published July 22, 2024
- Berg A, Berntsson RP, Barandun J
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POTRA domains of the TamA insertase interact with the outer membrane and modulate membrane properties.
- Proc Natl Acad Sci U S A - published July 9, 2024
- Mellouk A, Jaouen P, Ruel LJ, Lê M, Martini C, Moraes TF, El Bakkouri M, Lagüe P, Boisselier E, Calmettes C
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Roles for PMP22 in Schwann cell cholesterol homeostasis in health and disease.
- Biochem Soc Trans - published July 9, 2024
- Stefanski KM, Wilkinson MC, Sanders CR
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Functional and structural insights into RAS effector proteins.
- Mol Cell - published July 9, 2024
- Mozzarelli AM, Simanshu DK, Castel P
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CRISPR-based rapid molecular diagnostic tests for fusion-driven leukemias.
- Blood - published July 8, 2024
- Vedula RS, Karp HQ, Koob J, Lim F, Garcia JS, Winer ES, Luskin MR, Ghiaur G, Kim AS, Beppu LW, Sala-Torra O, Radich JP, Gootenberg JS, Abudayyeh O, Zhang F, Lindsley RC
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Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments.
- ChemMedChem - published July 8, 2024
- Tyndall J, Putha L, Kok LK, Fellner M, Rutledge MT, Gamble AB, Wilbanks SM, Vernall AJ
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Assessing and engineering the IscB-ωRNA system for programmed genome editing.
- Nat Chem Biol - published July 8, 2024
- Yan H, Tan X, Zou S, Sun Y, Ke A, Tang W
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The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation.
- Cell Rep - published July 8, 2024
- Xiao YX, Lee SY, Aguilera-Uribe M, Samson R, Au A, Khanna Y, Liu Z, Cheng R, Aulakh K, Wei J, Farias AG, Reilly T, Birkadze S, Habsid A, Brown KR, Chan K, Mero P, Huang JQ, Billmann M, Rahman M, Myers C, Andrews BJ, Youn JY, Yip CM, Rotin D, Derry WB, Forman-Kay JD, Moses AM, Pritišanac I, Gingras AC, Moffat J
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Chromosome compaction is triggered by an autonomous DNA-binding module within condensin.
- Cell Rep - published July 8, 2024
- Pastic A, Nosella ML, Kochhar A, Liu ZH, Forman-Kay JD, D'Amours D
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Development and Characterization of 50 nanometer diameter Genetically Encoded Multimeric Nanoparticles.
- bioRxiv - published July 7, 2024
- Hernandez CM, Duran-Chaparro DC, van Eeuwen T, Rout MP, Holt LJ
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The GoldX Fiducial Eraser.
- Int J Mol Sci - published July 6, 2024
- Van Blerkom P, Bezault A, Sauvanet C, Hanein D, Volkmann N
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TRPML1 gating modulation by allosteric mutations and lipids (Design of allosteric mutations that recapitulate the gating of TRPML1 ).
- bioRxiv - published July 6, 2024
- Gan N, Han Y, Zeng W, Jiang Y
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Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.
- bioRxiv - published July 5, 2024
- Giese APJ, Weng WH, Kindt KS, Chang HHV, Montgomery JS, Ratzan EM, Beirl AJ, Rivera RA, Lotthammer JM, Walujkar S, Foster MP, Zobeiri OA, Holt JR, Riazuddin S, Cullen KE, Sotomayor M, Ahmed ZM
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An intron endonuclease facilitates interference competition between coinfecting viruses.
- Science - published July 5, 2024
- Birkholz EA, Morgan CJ, Laughlin TG, Lau RK, Prichard A, Rangarajan S, Meza GN, Lee J, Armbruster E, Suslov S, Pogliano K, Meyer JR, Villa E, Corbett KD, Pogliano J
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Amino Acids and Their Biological Derivatives Modulate Protein-Protein Interactions in an Additive Way.
- J Phys Chem Lett - published July 5, 2024
- Xu X, Stellacci F
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An αIIbβ3 Monoclonal Antibody Traps a Semi-Extended Conformation and Allosterically Inhibits Large Ligand Binding.
- Blood Adv - published July 5, 2024
- Wang L, Wang J, Li J, Walz T, Coller BS
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Protocol to detect and quantify interactions between proteins expressed in Drosophila S2 cells.
- STAR Protoc - published July 5, 2024
- DeOliveira CC, Lin C, Crane BR
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NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.
- Sci Rep - published July 4, 2024
- Simoneau CR, Chen PY, Xing GK, Hayashi JM, Chen IP, Khalid MM, Meyers NL, Taha TY, Leon KE, Suryawanshi RK, McCavitt-Malvido M, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose JP, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M
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Memantine Inhibits Calcium-Permeable AMPA Receptors.
- bioRxiv - published July 4, 2024
- Carrillo E, Montaño Romero A, Gonzalez CU, Turcu AL, Chen SR, Chen H, Pan HL, Vázquez S, Twomey EC, Jayaraman V
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DCAF15 control of cohesin dynamics sustains acute myeloid leukemia.
- Nat Commun - published July 3, 2024
- Grothusen GP, Chang R, Cao Z, Zhou N, Mittal M, Datta A, Wulfridge P, Beer T, Wang B, Zheng N, Tang HY, Sarma K, Greenberg RA, Shi J, Busino L
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A µ-opioid receptor modulator that works cooperatively with naloxone.
- Nature - published July 3, 2024
- O'Brien ES, Rangari VA, El Daibani A, Eans SO, Hammond HR, White E, Wang H, Shiimura Y, Krishna Kumar K, Jiang Q, Appourchaux K, Huang W, Zhang C, Kennedy BJ, Mathiesen JM, Che T, McLaughlin JP, Majumdar S, Kobilka BK
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High-Density Lipoprotein Particle Concentration and Size Predict Incident Coronary Artery Disease Events in a Cohort With Type 1 Diabetes.
- J Am Heart Assoc - published July 3, 2024
- Costacou T, Vaisar T, Miller RG, Davidson WS, Heinecke JW, Orchard TJ, Bornfeldt KE
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Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats.
- Proc Natl Acad Sci U S A - published July 3, 2024
- Celona B, Salomonsson SE, Wu H, Dang B, Kratochvil HT, Clelland CD, DeGrado WF, Black BL
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Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.
- Proc Natl Acad Sci U S A - published July 3, 2024
- Zhong X, Moresco JJ, SoRelle JA, Song R, Jiang Y, Nguyen MT, Wang J, Bu CH, Moresco EMY, Beutler B, Choi JH
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High-resolution yeast actin structures indicate the molecular mechanism of actin filament stiffening by cations.
- Commun Chem - published July 3, 2024
- Xu XP, Cao W, Swift MF, Pandit NG, Huehn AE, Sindelar CV, De La Cruz EM, Hanein D, Volkmann N
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Missense variants in CMS22 patients reveal that PREPL has both enzymatic and non-enzymatic functions.
- JCI Insight - published July 3, 2024
- Monnens Y, Theodoropoulou A, Rosier K, Bhalla K, Mahy A, Vanhoutte R, Meulemans S, Cavani E, Antanasijevic A, Lemmens I, Lee JA, Spellicy CJ, Schroer RJ, Maselli RA, Laverty CG, Agostinis P, Pagliarini DJ, Verhelst S, Marcaida MJ, Rochtus A, Dal Peraro M, Creemers JW
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Unraveling the structure and function of a novel SegC protein interacting with the SegAB chromosome segregation complex in Archaea.
- Nucleic Acids Res - published July 3, 2024
- Lin MG, Yen CY, Shen YY, Huang YS, Ng IW, Barillà D, Sun YJ, Hsiao CD
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Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccine.
- Nat Commun - published July 3, 2024
- Kuzmin IV, Soto Acosta R, Pruitt L, Wasdin PT, Kedarinath K, Hernandez KR, Gonzales KA, Hill K, Weidner NG, Mire C, Engdahl TB, Moon WJ, Popov V, Crowe JE Jr, Georgiev IS, Garcia-Blanco MA, Abbott RK, Bukreyev A
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Mutagenesis Supports AlphaFold Prediction of How Modular Polyketide Synthase Acyl Carrier Proteins Dock With Downstream Ketosynthases.
- Proteins - published July 3, 2024
- Hirsch M, Desai RR, Annaswamy S, Keatinge-Clay AT
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Divergent folding-mediated epistasis among unstable membrane protein variants.
- Elife - published July 3, 2024
- Chamness LM, Kuntz CP, McKee AG, Penn WD, Hemmerich CM, Rusch DB, Woods H, Dyotima, Meiler J, Schlebach JP
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Cleavage-independent GSDME activation by UVC.
- Nat Cell Biol - published July 3, 2024
- Zhang E, Healy L, Du G, Wu H
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Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
- Nature - published July 3, 2024
- Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, Larsson HP, Nimigean CM
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A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates.
- Sci Transl Med - published July 3, 2024
- Arunachalam PS, Ha N, Dennison SM, Spreng RL, Seaton KE, Xiao P, Feng Y, Zarnitsyna VI, Kazmin D, Hu M, Santagata JM, Xie X, Rogers K, Shirreff LM, Chottin C, Spencer AJ, Dutta S, Prieto K, Julien JP, Tomai M, Fox CB, Villinger F, Hill AVS, Tomaras GD, Pulendran B
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Engineering bacterial biomanufacturing: characterization and manipulation of Sphingomonas sp. LM7 extracellular polymers.
- Soft Matter - published July 3, 2024
- van Wijngaarden EW, Goetsch AG, Brito IL, Hershey DM, Silberstein MN
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Nucleotide Immune Signaling in CBASS, Pycsar, Thoeris, and CRISPR Antiphage Defense.
- Annu Rev Microbiol - published July 3, 2024
- Hobbs SJ, Kranzusch PJ
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Structural switch in acetylcholine receptors in developing muscle.
- Nature - published July 3, 2024
- Li H, Teng J, Hibbs RE
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Author Correction: Antibodies targeting the glycan cap of Ebola virus glycoprotein are potent inducers of the complement system.
- Commun Biol - published July 3, 2024
- Ilinykh PA, Huang K, Gunn BM, Kuzmina NA, Kedarinath K, Jurado-Cobena E, Zhou F, Subramani C, Hyde MA, Velazquez JV, Williamson LE, Gilchuk P, Carnahan RH, Alter G, Crowe JE Jr, Bukreyev A
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Structural and dynamic changes in P-Rex1 upon activation by PIP(3) and inhibition by IP(4).
- Elife - published July 3, 2024
- Ravala SK, Adame-Garcia SR, Li S, Chen CL, Cianfrocco MA, Silvio Gutkind J, Cash JN, Tesmer JJG
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Metabolic profiling of different parts of Physalis alkekengi L. var. franchetii (Mast.) Makino based on UPLC-Q-Orbitrap-HRMS coupled with bioactivity assays.
- J Pharm Biomed Anal - published July 3, 2024
- Zhang C, Yang L, Gong Q, Liu X, Deng F
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Biochemical characterization of a high affinity phosphate transporter (PiPT) from root endophyte fungus Piriformospora indica.
- Protein Expr Purif - published July 3, 2024
- Kumar H, Bajaj A, Kumar P, Aggarwal R, Chalia V, Pradhan RK, Yadav R, Sinha S, Aggarwal V, Harries W, Dua M, Stroud RM, Johri AK
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Activation of the helper NRC4 immune receptor forms a hexameric resistosome.
- Cell - published July 3, 2024
- Liu F, Yang Z, Wang C, You Z, Martin R, Qiao W, Huang J, Jacob P, Dangl JL, Carette JE, Luan S, Nogales E, Staskawicz BJ
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Structural determinants of DNA cleavage by a CRISPR HNH-Cascade system.
- Mol Cell - published July 3, 2024
- Hirano S, Altae-Tran H, Kannan S, Macrae RK, Zhang F
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The potential for drug incompatibility and its drivers - A hospital wide retrospective descriptive study.
- Int J Med Inform - published July 3, 2024
- Keum N, Yoo J, Hur S, Shin SY, Dykes PC, Kang MJ, Lee YS, Cha WC
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Proteomic changes orchestrate metabolic acclimation of a unicellular diazotrophic cyanobacterium during light-dark cycle and nitrogen fixation states.
- bioRxiv - published July 3, 2024
- Panda P, Giri SJ, Sherman LA, Kihara D, Aryal UK
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Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules.
- Proc Natl Acad Sci U S A - published July 2, 2024
- Stark Y, Menard F, Jeliazkov JR, Ernst P, Chembath A, Ashraf M, Hine AV, Plückthun A
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Nanoscale architecture of synaptic vesicles and scaffolding complexes revealed by cryo-electron tomography.
- Proc Natl Acad Sci U S A - published July 2, 2024
- Held RG, Liang J, Brunger AT
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An interstrand DNA crosslink glycosylase aids Acinetobacter baumannii pathogenesis.
- Proc Natl Acad Sci U S A - published July 2, 2024
- Kunkle DE, Cai Y, Eichman BF, Skaar EP
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Observing isolated synaptic vesicle association and fusion ex vivo.
- Nat Protoc - published July 2, 2024
- Leitz J, Wang C, Esquivies L, Peters JJ, Gopal N, Pfuetzner RA, Wang AL, Brunger AT
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Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity.
- EMBO Rep - published July 2, 2024
- Russell J, Chen L, Liu A, Wang J, Ghosh S, Zhong X, Shi H, Beutler B, Nair-Gill E
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Structure and RNA-binding of the helically extended Roquin CCCH-type zinc finger.
- Nucleic Acids Res - published July 2, 2024
- Tants JN, Oberstrass L, Weigand JE, Schlundt A
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Protocol for phospho-SrcKD: rPTPεD1 complex preparation and BLI binding assays to demonstrate their exosite interface.
- STAR Protoc - published July 2, 2024
- EswarKumar N, TewarySunil K, Ho MC
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CCAR1 promotes DNA repair via alternative splicing.
- Mol Cell - published July 2, 2024
- Karasu ME, Jahnke L, Joseph BJ, Amerzhanova Y, Mironov A, Shu X, Schröder MS, Gvozdenovic A, Sala I, Zavolan M, Jonas S, Corn JE
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Low power supercycled TPPM decoupling.
- J Magn Reson - published July 2, 2024
- Garg R, DeZonia B, Paterson AL, Rienstra CM
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Conformational dynamics underlying atypical chemokine receptor 3 activation.
- Proc Natl Acad Sci U S A - published July 2, 2024
- Otun O, Aljamous C, Del Nero E, Arimont-Segura M, Bosma R, Zarzycka B, Girbau T, Leyrat C, de Graaf C, Leurs R, Durroux T, Granier S, Cong X, Bechara C
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Multimerization of TREM2 is impaired by Alzheimer's disease-associated variants.
- Alzheimers Dement - published July 2, 2024
- Dean HB, Greer RA, Yang SZ, Elston DS, Brett TJ, Roberson ED, Song Y
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Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases.
- Nat Biotechnol - published July 2, 2024
- Ferreira da Silva J, Tou CJ, King EM, Eller ML, Rufino-Ramos D, Ma L, Cromwell CR, Metovic J, Benning FMC, Chao LH, Eichler FS, Kleinstiver BP
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Time-Resolved Ion Mobility-Mass Spectrometry Reveals Structural Transitions in the Disassembly of Modular Polyketide Syntheses.
- J Am Soc Mass Spectrom - published July 2, 2024
- Zhao C, Slocum ST, Sherman DH, Ruotolo BT
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SARS-CoV-2 monoclonal antibody treatment followed by vaccination shifts human memory B cell epitope recognition suggesting antibody feedback.
- J Infect Dis - published July 2, 2024
- Bloom N, Ramirez SI, Cohn H, Parikh UM, Heaps A, Sieg SF, Greninger A, Ritz J, Moser C, Eron JJ, Bajic G, Currier JS, Klekotka P, Wohl DA, Daar ES, Li J, Hughes MD, Chew KW, Smith DM, Crotty S, Coelho CH, Accelerating COVID-19 Therapeutic Interventions and Vaccines–2/A5401 (ACTIV-2/A5401) Study Team
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Dissemination of pathogenic bacteria is reinforced by a MARTX toxin effector duet.
- Nat Commun - published July 2, 2024
- Choi S, Lee Y, Park S, Jang SY, Park J, Oh DW, Kim SM, Kim TH, Lee GS, Cho C, Kim BS, Lee D, Kim EH, Cheong HK, Moon JH, Song JJ, Hwang J, Kim MH
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Versatile roles of protein flavinylation in bacterial extracyotosolic electron transfer.
- mSystems - published July 2, 2024
- Huang S, Méheust R, Barquera B, Light SH
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Design, Synthesis, and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes and Applications in Single-Molecule Microscopy of Wild-Type Receptors.
- J Med Chem - published July 2, 2024
- Drakopoulos A, Koszegi Z, Seier K, Hübner H, Maurel D, Sounier R, Granier S, Gmeiner P, Calebiro D, Decker M
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Human TMEFF1 is a restriction factor for herpes simplex virus in the brain.
- Nature - published July 2, 2024
- Chan YH, Liu Z, Bastard P, Khobrekar N, Hutchison KM, Yamazaki Y, Fan Q, Matuozzo D, Harschnitz O, Kerrouche N, Nakajima K, Amin P, Yatim A, Rinchai D, Chen J, Zhang P, Ciceri G, Chen J, Dobbs K, Belkaya S, Lee D, Gervais A, Aydın K, Kartal A, Hasek ML, Zhao S, Reino EG, Lee YS, Seeleuthner Y, Chaldebas M, Bailey R, Vanhulle C, Lorenzo L, Boucherit S, Rozenberg F, Marr N, Mogensen TH, Aubart M, Cobat A, Dulac O, Emiroglu M, Paludan SR, Abel L, Notarangelo L, Longnecker R, Smith G, Studer L, Casanova JL, Zhang SY
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Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants.
- Nat Biotechnol - published July 2, 2024
- Frenkel M, Corban JE, Hujoel MLA, Morris Z, Raman S
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Cultivation and visualization of a methanogen of the phylum Thermoproteota.
- Nature - published July 2, 2024
- Kohtz AJ, Petrosian N, Krukenberg V, Jay ZJ, Pilhofer M, Hatzenpichler R
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Gas-Phase Unfolding Reveals Stability Shifts Associated with Substrate Binding in Modular Polyketide Synthases.
- J Am Soc Mass Spectrom - published July 2, 2024
- Zhao C, Borotto NB, Schmidt J, Srivastava K, Lowell A, Hakansson K, Sherman DH, Ruotolo BT
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Development of a humanized anti-FABP4 monoclonal antibody for potential treatment of breast cancer.
- Breast Cancer Res - published July 2, 2024
- Hao J, Jin R, Yi Y, Jiang X, Yu J, Xu Z, Schnicker NJ, Chimenti MS, Sugg SL, Li B
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UNC-45 assisted myosin folding depends on a conserved FX(3)HY motif implicated in Freeman Sheldon Syndrome.
- Nat Commun - published July 2, 2024
- Vogel A, Arnese R, Gudino Carrillo RM, Sehr D, Deszcz L, Bylicki A, Meinhart A, Clausen T
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CDK9 inhibition by dinaciclib is a therapeutic vulnerability in epithelioid hemangioendothelioma.
- Clin Cancer Res - published July 2, 2024
- Pobbati AV, Burtscher A, Rajaram Siva N, Hallett A, Romigh T, Che K, Zhao B, Coker JA, Wang N, Stauffer SR, Rubin BP
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Endogenous Fusarium Endophthalmitis after Bone Marrow Transplant: A Case Report and Literature Review.
- Vision (Basel) - published July 2, 2024
- Zhao CS, Wai K, Koo EB, Rahimy E, Mruthyunjaya P, Mahajan VB, DeBoer CMT
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Modular polyketide synthase ketosynthases collaborate with upstream dehydratases to install double bonds.
- Chem Commun (Camb) - published July 2, 2024
- Ray KA, Saif N, Keatinge-Clay AT
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SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition.
- Mol Cell - published July 2, 2024
- Zhang QE, Lindenberger J, Parsons RJ, Thakur B, Parks R, Park CS, Huang X, Sammour S, Janowska K, Spence TN, Edwards RJ, Martin M, Williams WB, Gobeil S, Montefiori DC, Korber B, Saunders KO, Haynes BF, Henderson R, Acharya P
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Safety and tolerability of the protein C activator AB002 in end-stage renal disease patients on hemodialysis: a randomized phase 2 trial.
- Commun Med (Lond) - published July 2, 2024
- Verbout NG, Lorentz CU, Markway BD, Wallisch M, Marbury TC, Di Cera E, Shatzel JJ, Gruber A, Tucker EI
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Competition shapes the landscape of X-chromosome-linked genetic diversity.
- Nat Genet - published July 2, 2024
- Buenaventura T, Bagci H, Patrascan I, Graham JJ, Hipwell KD, Oldenkamp R, King JWD, Urtasun J, Young G, Mouzo D, Gomez-Cabrero D, Rowland BD, Panne D, Fisher AG, Merkenschlager M
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ASCT2 is a major contributor to serine uptake in cancer cells.
- Cell Rep - published July 2, 2024
- Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns P, Rawat V, Lietuvninkas L, Sheldon R, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL
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SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity.
- Nat Microbiol - published July 2, 2024
- Peña-Hernández MA, Alfajaro MM, Filler RB, Moriyama M, Keeler EL, Ranglin ZE, Kong Y, Mao T, Menasche BL, Mankowski MC, Zhao Z, Vogels CBF, Hahn AM, Kalinich CC, Zhang S, Huston N, Wan H, Araujo-Tavares R, Lindenbach BD, Homer R, Pyle AM, Martinez DR, Grubaugh ND, Israelow B, Iwasaki A, Wilen CB
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Template-assisted covalent modification underlies activity of covalent molecular glues.
- Nat Chem Biol - published July 2, 2024
- Li YD, Ma MW, Hassan MM, Hunkeler M, Teng M, Puvar K, Rutter JC, Lumpkin RJ, Sandoval B, Jin CY, Schmoker AM, Ficarro SB, Cheong H, Metivier RJ, Wang MY, Xu S, Byun WS, Groendyke BJ, You I, Sigua LH, Tavares I, Zou C, Tsai JM, Park PMC, Yoon H, Majewski FC, Sperling HT, Marto JA, Qi J, Nowak RP, Donovan KA, Słabicki M, Gray NS, Fischer ES, Ebert BL
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Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions.
- Neuron - published July 2, 2024
- Lam I, Ndayisaba A, Lewis AJ, Fu Y, Sagredo GT, Kuzkina A, Zaccagnini L, Celikag M, Sandoe J, Sanz RL, Vahdatshoar A, Martin TD, Morshed N, Ichihashi T, Tripathi A, Ramalingam N, Oettgen-Suazo C, Bartels T, Boussouf M, Schäbinger M, Hallacli E, Jiang X, Verma A, Tea C, Wang Z, Hakozaki H, Yu X, Hyles K, Park C, Wang X, Theunissen TW, Wang H, Jaenisch R, Lindquist S, Stevens B, Stefanova N, Wenning G, van de Berg WDJ, Luk KC, Sanchez-Pernaute R, Gómez-Esteban JC, Felsky D, Kiyota Y, Sahni N, Yi SS, Chung CY, Stahlberg H, Ferrer I, Schöneberg J, Elledge SJ, Dettmer U, Halliday GM, Bartels T, Khurana V
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Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination.
- Cell Rep Med - published July 2, 2024
- Voss WN, Mallory MA, Byrne PO, Marchioni JM, Knudson SA, Powers JM, Leist SR, Dadonaite B, Townsend DR, Kain J, Huang Y, Satterwhite E, Castillo IN, Mattocks M, Paresi C, Munt JE, Scobey T, Seeger A, Premkumar L, Bloom JD, Georgiou G, McLellan JS, Baric RS, Lavinder JJ, Ippolito GC
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A tethering mechanism underlies Pin1-catalyzed proline cis-trans isomerization at a noncanonical site.
- bioRxiv - published July 2, 2024
- Williams CC, Chuck J, Munoz-Tello P, Kojetin DJ
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A genus-specific nsp12 region impacts polymerase assembly in Alpha- and Gammacoronaviruses.
- bioRxiv - published July 2, 2024
- Hoferle PJ, Anderson TK, Kirchdoerfer RN
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PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation.
- bioRxiv - published July 2, 2024
- Fang R, Vallius T, Zhang A, Van Cura D, Alicandri F, Fischer G, Draper E, Xu S, Pelletier R, Katsyv I, Sorger PK, Murphy GF, Lian CG
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Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA.
- bioRxiv - published July 2, 2024
- Megrian D, Martinez M, Alzari PM, Wehenkel AM
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Mechanism-guided engineering of a minimal biological particle for genome editing.
- bioRxiv - published July 2, 2024
- Ngo W, Peukes JT, Baldwin A, Xue ZW, Hwang S, Stickels RR, Lin Z, Satpathy AT, Wells JA, Schekman R, Nogales E, Doudna JA
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Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration.
- bioRxiv - published July 2, 2024
- Lv G, Sayles NM, Huang Y, Mancinelli CD, McAvoy K, Shneider NA, Manfredi G, Kawamata H, Eliezer D
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Expanding the substrate selectivity of the fimsbactin biosynthetic adenylation domain, FbsH.
- bioRxiv - published July 2, 2024
- Ahmed SF, Balutowski A, Yang J, Wencewicz TA, Gulick AM
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In-Silico Analyses of Molecular Force Sensors for Mechanical Characterization of Biological Systems.
- bioRxiv - published July 2, 2024
- Lopez DM, Castro CE, Sotomayor M
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Purification and Cryo-Electron Microscopy Analysis of Bacterial Appendages.
- Bio Protoc - published July 2, 2024
- Sanchez JC, Baumgardt JK, Wright ER
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Structural requirements for activity of Mind bomb1 in Notch signaling.
- Structure - published July 2, 2024
- Cao R, Gozlan O, Airich A, Tveriakhina L, Zhou H, Jiang H, Cole PA, Aster JC, Klein T, Sprinzak D, Blacklow SC
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Proteomic analysis of unicellular cyanobacterium Crocosphaera subtropica ATCC 51142 under extended light or dark growth.
- bioRxiv - published July 2, 2024
- Panda P, Giri SJ, Sherman L, Kihara D, Aryal UK
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Advancements in Ligand-Based Virtual Screening through the Synergistic Integration of Graph Neural Networks and Expert-Crafted Descriptors.
- bioRxiv - published July 1, 2024
- Liu YL, Moretti R, Wang Y, Dong H, Yan B, Bodenheimer B, Derr T, Meiler J
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Phospho-KNL-1 recognition by a TPR domain targets the BUB-1-BUB-3 complex to C. elegans kinetochores.
- J Cell Biol - published July 1, 2024
- Houston J, Vissotsky C, Deep A, Hakozaki H, Crews E, Oegema K, Corbett KD, Lara-Gonzalez P, Kim T, Desai A
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Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells.
- J Cell Biol - published July 1, 2024
- Chen YL, Jones AN, Crawford A, Sattler M, Ettinger A, Torres-Padilla ME
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The oligomeric states of dye-decolorizing peroxidases from Streptomyces lividans and their implications for mechanism of substrate oxidation.
- Protein Sci - published July 1, 2024
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A new lysine biosynthetic enzyme from a bacterial endosymbiont shaped by genetic drift and genome reduction.
- Protein Sci - published July 1, 2024
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Assessing the functional roles of coevolving PHD finger residues.
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Conserved C-Terminal Tail Is Responsible for Membrane Localization and Function of Pseudomonas aeruginosa Hemerythrin.
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Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy.
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VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates.
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Structural basis for Mis18 complex assembly and its implications for centromere maintenance.
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Limitations and Potential of κOR Biased Agonists for Pain and Itch Management.
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Bridging the microscopic divide: a comprehensive overview of micro-crystallization and in vivo crystallography.
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Comprehensive encoding of conformational and compositional protein structural ensembles through the mmCIF data structure.
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HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing.
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LRIG1 controls proliferation of adult neural stem cells by facilitating TGFβ and BMP signalling pathways.
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Targeting a microbiota Wolbachian aminoacyl-tRNA synthetase to block its pathogenic host.
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Structure of the flotillin complex in a native membrane environment.
- Proc Natl Acad Sci U S A - published July 1, 2024
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The West Nile virus genome harbors essential riboregulatory elements with conserved and host-specific functional roles.
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Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains.
- Proc Natl Acad Sci U S A - published July 1, 2024
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Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread.
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De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome.
- Nature - published July 1, 2024
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Author Correction: A new antibiotic traps lipopolysaccharide in its intermembrane transporter.
- Nature - published July 1, 2024
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Author Correction: A novel antibiotic class targeting the lipopolysaccharide transporter.
- Nature - published July 1, 2024
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Discovery of Uncommon Tryptophan-Containing Diketopiperazines from Aspergillus homomorphus CBS 101889 Using an Aspergillus nidulans Heterologous Expression System.
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Targeting soluble amyloid-beta oligomers with a novel nanobody.
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Phase Separation Modulates the Thermodynamics and Kinetics of RNA Hybridization.
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Modulating Weak Protein-Protein Cross-Interactions by the Addition of Free Amino Acids at Millimolar Concentrations.
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Polymerization of ZBTB transcription factors regulates chromatin occupancy.
- Mol Cell - published July 1, 2024
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Conformation of factor Xa in solution revealed by single molecule spectroscopy.
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Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38.
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Assembly of respiratory syncytial virus matrix protein lattice and its coordination with fusion glycoprotein trimers.
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An exopolysaccharide pathway from a freshwater Sphingomonas isolate.
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Native mass spectrometry and structural studies reveal modulation of MsbA-nucleotide interactions by lipids.
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Two-Metal Ion Mechanism of DNA Cleavage by Activated, Filamentous SgrAI.
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Structure and in vivo psoralen DNA crosslink repair activity of mycobacterial Nei2.
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Rational correction of pathogenic conformational defects in HTRA1.
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Kinetic and structural insights into the requirement of fungal tRNA ligase for a 2'-phosphate end.
- RNA - published July 1, 2024
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Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1.
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A systematic search for RNA structural switches across the human transcriptome.
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In vitro higher-order oligomeric assembly of the respiratory syncytial virus M2-1 protein with longer RNAs.
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Antibodies targeting the glycan cap of Ebola virus glycoprotein are potent inducers of the complement.
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A eukaryotic-like ubiquitination system in bacterial antiviral defence.
- Nature - published July 1, 2024
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Tubulin code eraser CCP5 binds branch glutamates by substrate deformation.
- Nature - published July 1, 2024
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Combined clinical, structural, and cellular studies discriminate pathogenic and benign TRPV4 variants.
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They all rock: A systematic comparison of conformational movements in LeuT-fold transporters.
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Molecular basis and functional consequences of the interaction between the Base Excision Repair DNA glycosylase NEIL1 and RPA.
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Mucosal signatures of pathogenic T cells in HLA-B*27+ anterior uveitis and axial spondyloarthritis.
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Allosteric activation of the co-receptor BAK1 by the EFR receptor kinase initiates immune signaling.
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Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation.
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Ligify: Automated Genome Mining for Ligand-Inducible Transcription Factors.
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Development of covalent chemogenetic K(2P) channel activators.
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Protein semisynthesis reveals plasticity in HECT E3 ubiquitin ligase mechanisms.
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Protein-protein interactions in the core nucleotide excision repair pathway.
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Structural Biology in Drug Discovery and Development: Call for Papers.
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Global siRNA Screen Reveals Critical Human Host Factors of SARS-CoV-2 Multicycle Replication.
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Proteostasis Landscapes of Selective versus Poorly Responsive CFTR Variants Reveals Structural Vulnerabilities to Correction.
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VARP binds SNX27 to promote endosomal supercomplex formation on membranes.
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The impact of Library Size and Scale of Testing on Virtual Screening.
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OpenTn5: Open-Source Resource for Robust and Scalable Tn5 Transposase Purification and Characterization.
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Structural Mapping of Polyclonal IgG Responses to HA After Influenza Virus Vaccination or Infection.
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Assembly mechanism of Integrator's RNA cleavage module.
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In vitro reconstitution of transition metal transporters.
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Humanization of Pan-HLA-DR mAb 44H10 Hinges on Critical Residues in the Antibody Framework.
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The Use of COVID-19 Mobile Apps in Connecting Patients with Primary Healthcare in 30 Countries: Eurodata Study.
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Deep Learning-Based Automated Measurement of Murine Bone Length in Radiographs.
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Selective Antineoplastic Potential of Fractionated Caribbean Native Ganoderma Species Extracts on Triple-Negative Breast Cancer Cells.
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CryoEM Workflow Acceleration with Feret Signatures.
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Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2.
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HIV-1-envelope trimer transitions from prefusion-closed to CD4-bound-open conformations through an occluded-intermediate state.
- bioRxiv - published July 1, 2024
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Dissecting human monoclonal antibody responses from mRNA- and protein-based XBB.1.5 COVID-19 monovalent vaccines.
- bioRxiv - published July 1, 2024
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Structure-Guided Design of Partial Agonists at an Opioid Receptor.
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Molecular basis of CRX/DNA recognition and stoichiometry at the Ret4 response element.
- Structure - published July 1, 2024
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CrysFormer: Protein structure determination via Patterson maps, deep learning, and partial structure attention.
- Struct Dyn - published July 1, 2024
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