Member Publications

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139 Member Publications for April 2024

TMC function, dysfunction, and restoration in mouse vestibular organs.
1. Front Neurol - published April 19, 2024
2. Ratzan EM, Lee J, Madison MA, Zhu H, Zhou W, Géléoc GSG, Holt JR
The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products.
1. PLoS One - published April 18, 2024
2. Garb J, Amitai G, Lu A, Ofir G, Brandis A, Mehlman T, Kranzusch PJ, Sorek R
Treatment algorithms of relapsing multiple sclerosis: an exploration based on the available disease-modifying therapies in China.
1. Ther Adv Neurol Disord - published April 15, 2024
2. Guo J, Wu J, Wang L, Liu H, Wu X, Yang H, Li W, Wang H, Bu B, Yang C, Zhou H, Guo S, Zhao Y, Wang Z, Li C, Tian DC, Chen S, Xue H, Zhang Y, Xu Y, Liang H, Wu Z, Zhang Y, Dong Q, Wang J, Quan C
Induction of islet autoimmunity to defective ribosomal product of the insulin gene as neoantigen after anti-cancer immunotherapy leading to autoimmune diabetes.
1. Front Immunol - published April 10, 2024
2. van Tienhoven R, Jansen DTSL, Park M, Williams JC, Larkin J, Quezada SA, Roep BO
Mechanism of autocatalytic activation during proteasome assembly.
1. Nat Struct Mol Biol - published April 10, 2024
2. Velez B, Walsh RM Jr, Rawson S, Razi A, Adams L, Perez EF, Jiao F, Blickling M, Rajakumar T, Fung D, Huang L, Hanna J
Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51.
1. Nat Cell Biol - published April 9, 2024
2. Liu A, Kage F, Abdulkareem AF, Aguirre-Huamani MP, Sapp G, Aydin H, Higgs HN
Emerging strategies for prospective discovery of molecular glue degraders.
1. Curr Opin Struct Biol - published April 9, 2024
2. Wang B, Cao S, Zheng N
The graduate school guide: How to prepare for the qualifying exam and assemble a thesis/graduate committee.
1. J Cell Physiol - published April 9, 2024
2. Rogers CD, Kirabo A, McReynolds M, Sweetwyne MT, Wanjalla C, Benjamin J, Williams EM, Gaddy JA, Williams CR, Damo SM, Murray SA, Hinton A Jr
Hypothiocyanous acid reductase is critical for host colonization and infection by Streptococcus pneumoniae.
1. J Biol Chem - published April 9, 2024
2. Shearer HL, Currie MJ, Agnew HN, Trappetti C, Stull F, Pace PE, Paton JC, Dobson RCJ, Dickerhof N
De novo variants in the non-coding spliceosomal snRNA gene RNU4-2 are a frequent cause of syndromic neurodevelopmental disorders.
1. medRxiv - published April 9, 2024
2. Chen Y, Dawes R, Kim HC, Stenton SL, Walker S, Ljungdahl A, Lord J, Ganesh VS, Ma J, Martin-Geary AC, Lemire G, D'Souza EN, Dong S, Ellingford JM, Adams DR, Allan K, Bakshi M, Baldwin EE, Berger SI, Bernstein JA, Brown NJ, Burrage LC, Chapman K, Compton AG, Cunningham CA, D'Souza P, Délot EC, Dias KR, Elias ER, Evans CA, Ewans L, Ezell K, Fraser JL, Gallacher L, Genetti CA, Grant CL, Haack T, Kuechler A, Lalani SR, Leitão E, Fevre AL, Leventer RJ, Liebelt JE, Lockhart PJ, Ma AS, Macnamara EF, Maurer TM, Mendez HR, Montgomery SB, Nassogne MC, Neumann S, O'Leary M, Palmer EE, Phillips J, Pitsava G, Pysar R, Rehm HL, Reuter CM, Revencu N, Riess A, Rius R, Rodan L, Roscioli T, Rosenfeld JA, Sachdev R, Simons C, Sisodiya SM, Snell P, Clair L, Stark Z, Tan TY, Tan NB, Temple SE, Thorburn DR, Tifft CJ, Uebergang E, VanNoy GE, Vilain E, Viskochil DH, Wedd L, Wheeler MT, White SM, Wojcik M, Wolfe LA, Wolfenson Z, Xiao C, Zocche D, Rubenstein JL, Markenscoff-Papadimitriou E, Fica SM, Baralle D, Depienne C, MacArthur DG, Howson JM, Sanders SJ, O'Donnell-Luria A, Whiffin N
Phase 1 trial evaluating safety and pharmacokinetics of HIV-1 broadly neutralizing mAbs 10E8VLS and VRC07-523LS.
1. JCI Insight - published April 8, 2024
2. Awan SF, Pegu A, Strom L, Carter CA, Hendel CS, Holman LA, Costner PJ, Trofymenko O, Dyer R, Gordon IJ, Rothwell RSS, Hickman SP, Conan-Cibotti M, Doria-Rose NA, Lin BC, O'Connell S, Narpala SR, Almasri CG, Liu C, Ko S, Kwon YD, Namboodiri AM, Pandey JP, Arnold FJ, Carlton K, Gall JG, Kwong PD, Capparelli EV, Bailer RT, McDermott AB, Chen GL, Koup RA, Mascola JR, Coates EE, Ledgerwood JE, Gaudinski MR, VRC 610 study team
The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili.
1. Nat Commun - published April 8, 2024
2. Zyla DS, Wiegand T, Bachmann P, Zdanowicz R, Giese C, Meier BH, Waksman G, Hospenthal MK, Glockshuber R
The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers.
1. Cancer Discov - published April 8, 2024
2. Ryan MB, Quade B, Schenk N, Fang Z, Zingg M, Cohen SE, Swalm BM, Li C, Ozen A, Ye C, Ritorto MS, Huang X, Dar AC, Han Y, Hoeflich KP, Hale M, Hagel M
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.
1. Nat Neurosci - published April 8, 2024
2. Hacisuleyman E, Hale CR, Noble N, Luo JD, Fak JJ, Saito M, Chen J, Weissman JS, Darnell RB
Intestinal inflammation marker calprotectin regulates epithelial intestinal zinc metabolism and proliferation in mouse jejunal organoids.
1. Biomed Pharmacother - published April 8, 2024
2. González R, Ceacero-Heras D, Tena-Garitaonaindia M, Álvarez-Mercado A, Gámez-Belmonte R, Chazin WJ, Sánchez de Medina F, Martínez-Augustin O
Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics.
1. bioRxiv - published April 7, 2024
2. Carlson RJ, Patten JJ, Stefanakis G, Soong BY, Radhakrishnan A, Singh A, Thakur N, Amarasinghe GK, Hacohen N, Basler CF, Leung D, Uhler C, Davey RA, Blainey PC
Uncovering Protein Ensembles: Automated Multiconformer Model Building for X-ray Crystallography and Cryo-EM.
1. bioRxiv - published April 6, 2024
2. Wankowicz SA, Ravikumar A, Sharma S, Riley BT, Raju A, Flowers J, Hogan D, van den Bedem H, Keedy DA, Fraser JS
NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation.
1. Cell Rep - published April 6, 2024
2. Yu T, Hou D, Zhao J, Lu X, Greentree WK, Zhao Q, Yang M, Conde DG, Linder ME, Lin H
The 3' UTR of vigR is required for virulence in Staphylococcus aureus and has expanded through STAR sequence repeat insertions.
1. Cell Rep - published April 6, 2024
2. Mediati DG, Dan W, Lalaouna D, Dinh H, Pokhrel A, Rowell KN, Michie KA, Stinear TP, Cain AK, Tree JJ
Biochemical characterization of E. coli DnaC variants that alter DnaB helicase loading onto DNA.
1. J Biol Chem - published April 6, 2024
2. McMillan SD, Keck JL
The structure of the monobactam-producing thioesterase domain of SulM forms a unique complex with the upstream carrier protein domain.
1. bioRxiv - published April 6, 2024
2. Patel KD, Oliver RA, Lichstrahl MS, Li R, Townsend CA, Gulick AM
De novo design of drug-binding proteins with predictable binding energy and specificity.
1. Science - published April 5, 2024
2. Lu L, Gou X, Tan SK, Mann SI, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti ME, Ashworth A, Polizzi NF, DeGrado WF
Nutritional, physicochemical, and functional properties of Hawaiian taro (Colocasia esculenta) flours: A comparative study.
1. J Food Sci - published April 5, 2024
2. Saxby SM, Dong L, Ho KKHY, Lee CN, Wall M, Li Y
Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes.
1. Sci Adv - published April 5, 2024
2. Sauer PV, Cupellini L, Sutter M, Bondanza M, Domínguez Martin MA, Kirst H, Bína D, Koh AF, Kotecha A, Greber BJ, Nogales E, Polívka T, Mennucci B, Kerfeld CA
Membrane Lipids Augment Cell Envelope Stress Signaling via the MadRS System to Defend Against Antimicrobial Peptides and Antibiotics in Enterococcus faecalis.
1. J Infect Dis - published April 5, 2024
2. Miller WR, Nguyen A, Singh KV, Rizvi S, Khan A, Erickson SG, Egge SL, Cruz M, Dinh AQ, Diaz L, Thornton PC, Zhang R, Xu L, Garsin DA, Shamoo Y, Arias CA
A highly optimized human in vitro translation system.
1. Cell Rep Methods - published April 5, 2024
2. Bothe A, Ban N
Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling.
1. Mol Cell - published April 5, 2024
2. Caveney NA, Rodriguez GE, Pollmann C, Meyer T, Borowska MT, Wilson SC, Wang N, Xiang X, Householder KD, Tao P, Su LL, Saxton RA, Piehler J, Garcia KC
RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells.
1. Cell - published April 5, 2024
2. Xia X, Sung PY, Martynowycz MW, Gonen T, Roy P, Zhou ZH
Anaerobic cryoEM protocols for air-sensitive nitrogenase proteins.
1. Nat Protoc - published April 4, 2024
2. Warmack RA, Wenke BB, Spatzal T, Rees DC
Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.
1. Front Mol Neurosci - published April 4, 2024
2. Chofflet N, Naito Y, Pastore AJ, Padmanabhan N, Nguyen PT, Poitras C, Feller B, Yi N, Van Prooijen J, Khaled H, Coulombe B, Clapcote SJ, Bourgault S, Siddiqui TJ, Rudenko G, Takahashi H
The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2.
1. PLoS Pathog - published April 4, 2024
2. de Sautu M, Herrmann T, Scanavachi G, Jenni S, Harrison SC
Intrinsic disorder: A term to define the specific physicochemical characteristic of protein conformational heterogeneity.
1. Mol Cell - published April 4, 2024
2. Lemke EA, Babu MM, Kriwacki RW, Mittag T, Pappu RV, Wright PE, Forman-Kay JD
Structural characterization of methylation-independent PP2A assembly guides Alphafold2Multimer prediction of family-wide PP2A complexes.
1. J Biol Chem - published April 4, 2024
2. Wachter F, Nowak RP, Ficarro S, Marto J, Fischer ES
Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors.
1. Cell Chem Biol - published April 4, 2024
2. Dates AN, Jones DTD, Smith JS, Skiba MA, Rich MF, Burruss MM, Kruse AC, Blacklow SC
Activating point mutations in the MET kinase domain represent a unique molecular subset of lung cancer and other malignancies targetable with MET inhibitors.
1. Cancer Discov - published April 3, 2024
2. Pecci F, Nakazawa S, Ricciuti B, Harada G, Lee JK, Alessi JV, Barrichello A, Vaz VR, Lamberti G, Di Federico A, Gandhi MM, Gazgalis D, Feng WW, Jiang J, Baldacci S, Locquet MA, Gottlieb FH, Chen MF, Lee E, Haradon D, Smokovich A, Voligny E, Nguyen T, Goel VK, Zimmerman Z, Atwal S, Wang X, Bahcall M, Heist RS, Iqbal S, Gandhi N, Elliott A, Vanderwalde AM, Ma PC, Halmos B, Liu SV, Che J, Schrock AB, Drilon A, Janne PA, Awad MM
Therapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primates.
1. Sci Transl Med - published April 3, 2024
2. Zeitlin L, Cross RW, Woolsey C, West BR, Borisevich V, Agans KN, Prasad AN, Deer DJ, Stuart L, McCavitt-Malvido M, Kim DH, Pettitt J, Crowe JE Jr, Whaley KJ, Veesler D, Dimitrov A, Abelson DM, Geisbert TW, Broder CC
Buffer Choice and pH Strongly Influence Phase Separation of SARS-CoV-2 Nucleocapsid with RNA.
1. Mol Biol Cell - published April 3, 2024
2. Kathe NC, Novakovic M, Allain FH
Combining Rosetta Sequence Design with Protein Language Model Predictions Using Evolutionary Scale Modeling (ESM) as Restraint.
1. ACS Synth Biol - published April 3, 2024
2. Ertelt M, Meiler J, Schoeder CT
Cell penetration of oxadiazole-containing macrocycles.
1. RSC Chem Biol - published April 3, 2024
2. Huh S, Batistatou N, Wang J, Saunders GJ, Kritzer JA, Yudin AK
Variable orthogonality of RDF - large serine integrase interactions within the ϕC31 family.
1. bioRxiv - published April 3, 2024
2. MacDonald AI, Baksh A, Holland A, Shin H, Rice PA, Stark WM, Olorunniji FJ
Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis.
1. Proc Natl Acad Sci U S A - published April 3, 2024
2. Hou D, Yu T, Lu X, Hong JY, Yang M, Zi Y, Ho TT, Lin H
Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
1. Nat Commun - published April 3, 2024
2. Hibshman GN, Bravo JPK, Hooper MM, Dangerfield TL, Zhang H, Finkelstein IJ, Johnson KA, Taylor DW
Keratin isoform shifts modulate motility signals during wound healing.
1. bioRxiv - published April 2, 2024
2. Nanes BA, Bhatt K, Boujemaa-Paterski R, Azarova E, Munawar S, Rajendran D, Isogai T, Dean KM, Medalia O, Danuser G
Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters.
1. bioRxiv - published April 2, 2024
2. Reddy KD, Rasool B, Akher FB, Kutlešić N, Pant S, Boudker O
Correction: Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications.
1. Breast Cancer Res - published April 2, 2024
2. Bashari MH, Fan F, Vallet S, Sattler M, Arn M, Luckner-Minden C, Schulze-Bergkamen H, Zörnig I, Marme F, Schneeweiss A, Cardone MH, Opferman JT, Jäger D, Podar K
Structural basis for promiscuity in ligand recognition by yjdF riboswitch.
1. Cell Discov - published April 2, 2024
2. Krochmal D, Roman C, Lewicka A, Shao Y, Piccirilli JA
Author Correction: Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology.
1. Nat Commun - published April 2, 2024
2. Filandr F, Sarpe V, Raval S, Crowder DA, Khan MF, Douglas P, Coales S, Viner R, Syed A, Tainer JA, Lees-Miller SP, Schriemer DC
Backbone chemical shift and secondary structure assignments for mouse siderocalin.
1. Biomol NMR Assign - published April 2, 2024
2. Moeller J, Bozhanova NG, Voehler M, Meiler J, Schoeder CT
Author Correction: SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
1. Nature - published April 2, 2024
2. Barnes CO, Jette CA, Abernathy ME, Dam KA, Esswein SR, Gristick HB, Malyutin AG, Sharaf NG, Huey-Tubman KE, Lee YE, Robbiani DF, Nussenzweig MC, West AP Jr, Bjorkman PJ
Structural basis of ligand specificity and channel activation in an insect gustatory receptor.
1. Cell Rep - published April 2, 2024
2. Frank HM, Walujkar S, Walsh RM Jr, Laursen WJ, Theobald DL, Garrity PA, Gaudet R
Viral Receptor-Binding Protein Evolves New Function through Mutations That Cause Trimer Instability and Functional Heterogeneity.
1. Mol Biol Evol - published April 2, 2024
2. Strobel HM, Labador SD, Basu D, Sane M, Corbett KD, Meyer JR
NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks.
1. Cell - published April 2, 2024
2. David L, Borges JP, Hollingsworth LR, Volchuk A, Jansen I, Garlick E, Steinberg BE, Wu H
Proof-of-concept studies with a computationally designed M(pro) inhibitor as a synergistic combination regimen alternative to Paxlovid.
1. Proc Natl Acad Sci U S A - published April 2, 2024
2. Papini C, Ullah I, Ranjan AP, Zhang S, Wu Q, Spasov KA, Zhang C, Mothes W, Crawford JM, Lindenbach BD, Uchil PD, Kumar P, Jorgensen WL, Anderson KS
Lipid scrambling is a general feature of protein insertases.
1. Proc Natl Acad Sci U S A - published April 2, 2024
2. Li D, Rocha-Roa C, Schilling MA, Reinisch KM, Vanni S
Cryo-EM Structure of AAV2 Rep68 bound to integration site AAVS1: Insights into the mechanism of DNA melting.
1. bioRxiv - published April 2, 2024
2. Jaiswal R, Santosh V, Braud B, Washington A, Escalante CR
Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex.
1. Proc Natl Acad Sci U S A - published April 2, 2024
2. Nguyen DM, Rath DH, Devost D, Pétrin D, Rizk R, Ji AX, Narayanan N, Yong D, Zhai A, Kuntz DA, Mian MUQ, Pomroy NC, Keszei AFA, Benlekbir S, Mazhab-Jafari MT, Rubinstein JL, Hébert TE, Privé GG
Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix.
1. Proc Natl Acad Sci U S A - published April 2, 2024
2. Bellone S, Jeong K, Halle MK, Krakstad C, McNamara B, Greenman M, Mutlu L, Demirkiran C, Hartwich TMP, Yang-Hartwich Y, Zipponi M, Buza N, Hui P, Raspagliesi F, Lopez S, Paolini B, Milione M, Perrone E, Scambia G, Altwerger G, Ravaggi A, Bignotti E, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz PE, Quick CM, Angioli R, Terranova C, Zaidi S, Nandi S, Alexandrov LB, Siegel ER, Choi J, Schlessinger J, Santin AD
A comprehensive dataset of protein-protein interactions and ligand binding pockets for advancing drug discovery.
1. Sci Data - published April 2, 2024
2. Moine-Franel A, Mareuil F, Nilges M, Ciambur CB, Sperandio O
NLRP inflammasomes in health and disease.
1. Mol Biomed - published April 2, 2024
2. Xu Z, Kombe Kombe AJ, Deng S, Zhang H, Wu S, Ruan J, Zhou Y, Jin T
GS-441524-Diphosphate-Ribose Derivatives as Nanomolar Binders and Fluorescence Polarization Tracers for SARS-CoV-2 and Other Viral Macrodomains.
1. ACS Chem Biol - published April 2, 2024
2. Peng K, Wallace SD, Bagde SR, Shang J, Anmangandla A, Jana S, Fromme JC, Lin H
Compositional Analysis of Complex Mixtures using Automatic MicroED Data Collection.
1. Adv Sci (Weinh) - published April 2, 2024
2. Unge J, Lin J, Weaver SJ, Sae Her A, Gonen T
Covalent Polymer-RNA Conjugates for Potent Activation of the RIG-I Pathway.
1. Adv Healthc Mater - published April 2, 2024
2. Palmer CR, Pastora LE, Kimmel BR, Pagendarm HM, Kwiatkowski AJ, Stone PT, Arora K, Francini N, Fedorova O, Pyle AM, Wilson JT
Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway.
1. Nat Microbiol - published April 2, 2024
2. Yan Y, Xiao J, Huang F, Xian W, Yu B, Cheng R, Wu H, Lu X, Wang X, Huang W, Li J, Oyejobi GK, Robinson CV, Wu H, Wu D, Liu X, Wang L, Zhu B
Nanoparticle Retinoic Acid-Inducible Gene I Agonist for Cancer Immunotherapy.
1. ACS Nano - published April 2, 2024
2. Wang-Bishop L, Wehbe M, Pastora LE, Yang J, Kimmel BR, Garland KM, Becker KW, Carson CS, Roth EW, Gibson-Corley KN, Ulkoski D, Krishnamurthy V, Fedorova O, Richmond A, Pyle AM, Wilson JT
Human Airway and Alveolar Organoids from Bronchoalveolar Lavage Fluid.
1. Am J Respir Crit Care Med - published April 2, 2024
2. Liu MY, Chen B, Borji M, Garcia de Alba Rivas C, Dost AFM, Moye AL, Movval Abdulla N, Paschini M, Rollins SD, Wang R, Schnapp LM, Khalil HA, Wu CJ, Sharma NS, Kim CF
Discovering mechanisms of human genetic variation and controlling cell states at scale.
1. Trends Genet - published April 2, 2024
2. Frenkel M, Raman S
PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association.
1. Elife - published April 2, 2024
2. Proske M, Janowski R, Bacher S, Kang HS, Monecke T, Koehler T, Hutten S, Tretter J, Crois A, Molitor L, Varela-Rial A, Fino R, Donati E, De Fabritiis G, Dormann D, Sattler M, Niessing D
Structural basis for α-tubulin-specific and modification state-dependent glutamylation.
1. Nat Chem Biol - published April 2, 2024
2. Mahalingan KK, Grotjahn DA, Li Y, Lander GC, Zehr EA, Roll-Mecak A
Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry.
1. Bioconjug Chem - published April 2, 2024
2. Auger SA, Venkatachalapathy S, Suazo KFG, Wang Y, Sarkis AW, Bernhagen K, Justyna K, Schaefer JV, Wollack JW, Plückthun A, Li L, Distefano MD
NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair.
1. DNA Repair (Amst) - published April 2, 2024
2. Oswalt LE, Eichman BF
Engineering, structure, and immunogenicity of a Crimean-Congo hemorrhagic fever virus pre-fusion heterotrimeric glycoprotein complex.
1. bioRxiv - published April 2, 2024
2. McFadden E, Monticelli SR, Wang A, Ramamohan AR, Batchelor TG, Kuehne AI, Bakken RR, Tse AL, Chandran K, Herbert AS, McLellan JS
Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists.
1. bioRxiv - published April 2, 2024
2. Hollingsworth LR, Veeraraghavan P, Paulo JA, Harper JW, Rauch I
Transcriptome-wide mRNA condensation precedes stress granule formation and excludes stress-induced transcripts.
1. bioRxiv - published April 2, 2024
2. Glauninger H, Bard JAM, Wong Hickernell CJ, Airoldi EM, Li W, Singer RH, Paul S, Fei J, Sosnick TR, Wallace EWJ, Allan Drummond D
Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction.
1. Cell Host Microbe - published April 2, 2024
2. Wiehe K, Saunders KO, Stalls V, Cain DW, Venkatayogi S, Martin Beem JS, Berry M, Evangelous T, Henderson R, Hora B, Xia SM, Jiang C, Newman A, Bowman C, Lu X, Bryan ME, Bal J, Sanzone A, Chen H, Eaton A, Tomai MA, Fox CB, Tam YK, Barbosa C, Bonsignori M, Muramatsu H, Alam SM, Montefiori DC, Williams WB, Pardi N, Tian M, Weissman D, Alt FW, Acharya P, Haynes BF
Chemical screening by time-resolved X-ray scattering to discover allosteric probes.
1. Nat Chem Biol - published April 2, 2024
2. Brosey CA, Link TM, Shen R, Moiani D, Burnett K, Hura GL, Jones DE, Tainer JA
Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins.
1. Nat Struct Mol Biol - published April 2, 2024
2. Khare S, Villalba MI, Canul-Tec JC, Cajiao AB, Kumar A, Backovic M, Rey FA, Pardon E, Steyaert J, Perez C, Reyes N
Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques.
1. Nat Commun - published April 2, 2024
2. Kaiser JA, Nelson CE, Liu X, Park HS, Matsuoka Y, Luongo C, Santos C, Ahlers LRH, Herbert R, Moore IN, Wilder-Kofie T, Moore R, Walker A, Yang L, Munir S, Teng IT, Kwong PD, Dowdell K, Nguyen H, Kim J, Cohen JI, Johnson RF, Garza NL, Via LE, Barber DL, Buchholz UJ, Le Nouën C
The hinge-engineered IgG1-IgG3 hybrid subclass IgGh(47) potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies.
1. Nat Commun - published April 2, 2024
2. Izadi A, Karami Y, Bratanis E, Wrighton S, Khakzad H, Nyblom M, Olofsson B, Happonen L, Tang D, Sundwall M, Godzwon M, Chao Y, Toledo AG, Schmidt T, Ohlin M, Nilges M, Malmström J, Bahnan W, Shannon O, Malmström L, Nordenfelt P
Mapping the contribution of C-linker domain to gating polarity in CNBD channels.
1. Biophys J - published April 2, 2024
2. Lin JL, Chang Y, Tewari D, Cowgill J, Chanda B
Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput.
1. Nat Methods - published April 2, 2024
2. Kennedy PH, Alborzian Deh Sheikh A, Balakar M, Jones AC, Olive ME, Hegde M, Matias MI, Pirete N, Burt R, Levy J, Little T, Hogan PG, Liu DR, Doench JG, Newton AC, Gottschalk RA, de Boer CG, Alarcón S, Newby GA, Myers SA
Structural basis of closed groove scrambling by a TMEM16 protein.
1. Nat Struct Mol Biol - published April 2, 2024
2. Feng Z, Alvarenga OE, Accardi A
Targeted protein degradation: from mechanisms to clinic.
1. Nat Rev Mol Cell Biol - published April 2, 2024
2. Tsai JM, Nowak RP, Ebert BL, Fischer ES
Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target.
1. J Med Chem - published April 2, 2024
2. Hargrove TY, Lamb DC, Wawrzak Z, Hull M, Kelly SL, Guengerich FP, Lepesheva GI
Author Correction: Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF.
1. Nature - published April 2, 2024
2. Radko-Juettner S, Yue H, Myers JA, Carter RD, Robertson AN, Mittal P, Zhu Z, Hansen BS, Donovan KA, Hunkeler M, Rosikiewicz W, Wu Z, McReynolds MG, Roy Burman SS, Schmoker AM, Mageed N, Brown SA, Mobley RJ, Partridge JF, Stewart EA, Pruett-Miller SM, Nabet B, Peng J, Gray NS, Fischer ES, Roberts CWM
Missing Wedge Completion via Unsupervised Learning with Coordinate Networks.
1. bioRxiv - published April 2, 2024
2. Van Veen D, Galaz-Montoya JG, Shen L, Baldwin P, Chaudhari AS, Lyumkis D, Schmid MF, Chiu W, Pauly J
A deoxynucleoside triphosphate triphosphohydrolase promotes cell cycle progression in Caulobacter crescentus.
1. bioRxiv - published April 2, 2024
2. Hellenbrand CN, Stevenson DM, Gromek KA, Amador-Noguez D, Hershey DM
Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states.
1. bioRxiv - published April 2, 2024
2. MacTavish B, Zhu D, Shang J, Shao Q, Yang ZJ, Kamenecka TM, Kojetin DJ
Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation.
1. bioRxiv - published April 2, 2024
2. Hu Y, Lopez VA, Xu H, Pfister JP, Song B, Servage KA, Sakurai M, Jones BT, Mendell JT, Wang T, Wu J, Lambowitz AM, Tomchick DR, Pawłowski K, Tagliabracci VS
Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations.
1. bioRxiv - published April 2, 2024
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Cell-free assays reveal the HIV-1 capsid protects reverse transcripts from cGAS.
1. bioRxiv - published April 2, 2024
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Transcription of HIV-1 at sites of intact latent provirus integration.
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Connexin Gap Junction Channels and Hemichannels: Insights from High-Resolution Structures.
1. Biology (Basel) - published April 2, 2024
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Development of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library.
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STING guides the STX17-SNAP29-VAMP8 complex assembly to control autophagy.
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Structural determination and modeling of ciliary microtubules.
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Efficient and economic protein labeling for NMR in mammalian expression systems: Application to a preT-cell and T-cell receptor protein.
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Integrating the analysis of human biopsies using post-translational modifications proteomics.
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Bridging structural and cell biology with cryo-electron microscopy.
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ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin.
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From solution to structure: empowering inclusive cryo-EM with a pre-characterization pipeline for biological samples.
1. J Appl Crystallogr - published April 1, 2024
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Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
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ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.
1. Nature - published April 1, 2024
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DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues.
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An adaptive biomolecular condensation response is conserved across environmentally divergent species.
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A targetable receptor-binding site on PfCyRPA to aid in the fight against malaria.
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Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer.
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A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments.
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Structural basis for human Ca(v)3.2 inhibition by selective antagonists.
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Medicinal and edible polysaccharides from ancient plants: extraction, isolation, purification, structure, biological activity and market trends of sea buckthorn polysaccharides.
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Plant-derived flavonoids are a potential source of drugs for the treatment of liver fibrosis.
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Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis.
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Structural Basis of Non-Latent Signaling by the Anti-Müllerian Hormone Procomplex.
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Skin emitted volatiles analysis for noninvasive diagnosis: the current advances in sample preparation techniques for biomedical application.
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Molecular basis of Gabija anti-phage supramolecular assemblies.
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DNA glycosylases provide antiviral defence in prokaryotes.
1. Nature - published April 1, 2024
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HS-AFM single-molecule structural biology uncovers basis of transporter wanderlust kinetics.
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Modulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif.
1. Nat Commun - published April 1, 2024
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CryoEM structures reveal how the bacterial flagellum rotates and switches direction.
1. Nat Microbiol - published April 1, 2024
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Promiscuous G-protein activation by the calcium-sensing receptor.
1. Nature - published April 1, 2024
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Discovery of Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening.
1. ACS Pharmacol Transl Sci - published April 1, 2024
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A secreted bacterial protein protects bacteria from cationic antimicrobial peptides by entrapment in phase-separated droplets.
1. PNAS Nexus - published April 1, 2024
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RNA targeting and cleavage by the type III-Dv CRISPR effector complex.
1. Nat Commun - published April 1, 2024
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Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages.
1. Immunity - published April 1, 2024
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Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells.
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Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.
1. Eur J Cell Biol - published April 1, 2024
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Sulfate-reducing bacteria (SRB) mediated carbonate dissolution and arsenic release: Behavior and mechanisms.
1. Sci Total Environ - published April 1, 2024
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The making and breaking of tRNAs by ribonucleases.
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The M3 muscarinic acetylcholine receptor can signal through multiple G protein families.
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Ensuring a sustained workforce to combat antibiotic resistance in the 21st century: the critical need for training the next-gen of scientists at the pre-doctoral level.
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Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis.
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Automated liver volumetry and hepatic steatosis quantification with magnetic resonance imaging proton density fat fraction.
1. J Formos Med Assoc - published April 1, 2024
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Small-Molecule Inhibitors of the m7G-RNA Writer METTL1.
1. ACS Bio Med Chem Au - published April 1, 2024
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Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST.
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Glia-derived secretory fatty acid binding protein Obp44a regulates lipid storage and efflux in the developing Drosophila brain.
1. bioRxiv - published April 1, 2024
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Assembly of the Bacterial Ribosome with Circularly Permuted rRNA.
1. bioRxiv - published April 1, 2024
2. Dong X, Sheng K, Gebert LFR, Aiyer S, MacRae IJ, Lyumkis D, Williamson JR
Multiple pathways for licensing human replication origins.
1. bioRxiv - published April 1, 2024
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Functional and antigenic landscape of the Nipah virus receptor binding protein.
1. bioRxiv - published April 1, 2024
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Molecular basis of proton-sensing by G protein-coupled receptors.
1. bioRxiv - published April 1, 2024
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Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses.
1. Immunity - published April 1, 2024
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