Member Publications

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142 Member Publications for June 2023

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
1. bioRxiv - published June 28, 2023
2. Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken SJ, Locksley RM, Fraser JS
The structure of a Type III-A CRISPR-Cas effector complex reveals conserved and idiosyncratic contacts to target RNA and crRNA among Type III-A systems.
1. PLoS One - published June 23, 2023
2. Paraan M, Nasef M, Chou-Zheng L, Khweis SA, Schoeffler AJ, Hatoum-Aslan A, Stagg SM, Dunkle JA
Bioprocess development for universal influenza vaccines based on inactivated split chimeric and mosaic hemagglutinin viruses.
1. Front Bioeng Biotechnol - published June 21, 2023
2. Puente-Massaguer E, Beyer A, Loganathan M, Sapse I, Carreño JM, Bajic G, Sun W, Palese P, Krammer F
Magnetic resonance imaging using a nonuniform Bo (NuBo) field-cycling magnet.
1. PLoS One - published June 15, 2023
2. Selvaganesan K, Wan Y, Ha Y, Wu B, Hancock K, Galiana G, Constable RT
Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis.
1. PLoS One - published June 13, 2023
2. Bajaj T, Kuriyan J, Gee CL
Rapid Kinetics of Pistol Ribozyme: Insights into Limits to RNA Catalysis.
1. Biochemistry - published June 9, 2023
2. Yoon S, Ollie E, York DM, Piccirilli JA, Harris ME
Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase.
1. J Med Chem - published June 9, 2023
2. Singh I, Li F, Fink EA, Chau I, Li A, Rodriguez-Hernández A, Glenn I, Zapatero-Belinchón FJ, Rodriguez ML, Devkota K, Deng Z, White K, Wan X, Tolmachova NA, Moroz YS, Kaniskan HÜ, Ott M, García-Sastre A, Jin J, Fujimori DG, Irwin JJ, Vedadi M, Shoichet BK
Mild SARS-CoV-2 infection results in long-lasting microbiota instability.
1. mBio - published June 9, 2023
2. Upadhyay V, Suryawanshi RK, Tasoff P, McCavitt-Malvido M, Kumar RG, Murray VW, Noecker C, Bisanz JE, Hswen Y, Ha CWY, Sreekumar B, Chen IP, Lynch SV, Ott M, Lee S, Turnbaugh PJ
Systematic detection of tertiary structural modules in large RNAs and RNP interfaces by Tb-seq.
1. Nat Commun - published June 9, 2023
2. Patel S, Sexton AN, Strine MS, Wilen CB, Simon MD, Pyle AM
Tryptophan-like side chain holding aptamers inhibit respiratory syncytial virus infection of lung epithelial cells.
1. Sci Rep - published June 9, 2023
2. Percze K, Tolnai ZJ, Eleveld M, Ou L, Du H, Olia AS, Kwong PD, de Jonge MI, Mészáros T
A recombinant technique for mapping functional sites of hetero-trimeric collagen helices: collagen IV CB3 fragment as a prototype for integrin binding.
1. J Biol Chem - published June 9, 2023
2. Boudko SP, Konopka EH, Kim W, Taga Y, Mizuno K, Springer TA, Hudson BG, Moy TI, Lin FY
Chiral growth of adherent filopodia.
1. Biophys J - published June 9, 2023
2. Li W, Chung WL, Kozlov MM, Medalia O, Geiger B, Bershadsky AD
Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication.
1. RSC Adv - published June 9, 2023
2. Bajaj T, Wehri E, Suryawanshi RK, King E, Pardeshi KS, Behrouzi K, Khodabakhshi Z, Schulze-Gahmen U, Kumar GR, Mofrad MRK, Nomura DK, Ott M, Schaletzky J, Murthy N
Structure of a modular polyketide synthase reducing region.
1. Structure - published June 9, 2023
2. McCullough TM, Dhar A, Akey DL, Konwerski JR, Sherman DH, Smith JL
Targeted adenovirus-mediated transduction of human T cells in vitro and in vivo.
1. Mol Ther Methods Clin Dev - published June 8, 2023
2. Freitag PC, Kaulfuss M, Flühler L, Mietz J, Weiss F, Brücher D, Kolibius J, Hartmann KP, Smith SN, Münz C, Chijioke O, Plückthun A
Molecular earplugs to protect the inner ear.
1. Mol Ther Methods Clin Dev - published June 8, 2023
2. Chaves MG, Holt JR
Hexahydroquinoline Derivatives are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1/GPR56.
1. Mol Pharmacol - published June 8, 2023
2. Vizurraga AL, Robertson MJ, Yu M, Skiniotis G, Tall GG
Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression.
1. Nat Methods - published June 8, 2023
2. Zengel J, Wang YX, Seo JW, Ning K, Hamilton JN, Wu B, Raie M, Holbrook C, Su S, Clements DR, Pillay S, Puschnik AS, Winslow MM, Idoyaga J, Nagamine CM, Sun Y, Mahajan VB, Ferrara KW, Blau HM, Carette JE
Molecular Dynamics Simulations with Grand-Canonical Reweighting Suggest Cooperativity Effects in RNA Structure Probing Experiments.
1. J Chem Theory Comput - published June 8, 2023
2. Calonaci N, Bernetti M, Jones A, Sattler M, Bussi G
Vaccine elicitation and structural basis for antibody protection against alphaviruses.
1. Cell - published June 8, 2023
2. Sutton MS, Pletnev S, Callahan V, Ko S, Tsybovsky Y, Bylund T, Casner RG, Cerutti G, Gardner CL, Guirguis V, Verardi R, Zhang B, Ambrozak D, Beddall M, Lei H, Yang ES, Liu T, Henry AR, Rawi R, Schön A, Schramm CA, Shen CH, Shi W, Stephens T, Yang Y, Florez MB, Ledgerwood JE, Burke CW, Shapiro L, Fox JM, Kwong PD, Roederer M
Juneteenth in STEMM and the barriers to equitable science.
1. Cell - published June 8, 2023
2. Mays A, Byars-Winston A, Hinton A Jr, Marshall AG, Kirabo A, August A, Marlin BJ, Riggs B, Tolbert B, Wanjalla C, Womack C, Evans CS, Barnes C, Starbird C, Williams C, Reynolds C, Taabazuing C, Cameron CE, Murray DD, Applewhite D, Morton DJ, Lee D, Williams DW, Lynch D, Brady D, Lynch E, Rutaganira FUN, Silva GM, Shuler H, Saboor IA, Davis J, Dzirasa K, Hammonds-Odie L, Reyes L, Sweetwyne MT, McReynolds MR, Johnson MDL, Smith NA, Pittman N, Ajijola OA, Smith Q, Robinson RAS, Lewis SC, Murray SA, Black S, Neal SE, Andrisse S, Townsend S, Damo SM, Griffith TN, Lambert WM, Clemons WM Jr
Disease mutations and phosphorylation alter the allosteric pathways involved in autoinhibition of protein phosphatase 2A.
1. J Chem Phys - published June 7, 2023
2. Konovalov KA, Wu CG, Qiu Y, Balakrishnan VK, Parihar PS, O'Connor MS, Xing Y, Huang X
The role of CenKR in the coordination of Rhodobacter sphaeroides cell elongation and division.
1. mBio - published June 7, 2023
2. Lakey BD, Alberge F, Parrell D, Wright ER, Noguera DR, Donohue TJ
Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power.
1. Chemistry - published June 7, 2023
2. Hobbs KF, Propp J, Vance NR, Kalenkiewicz A, Witkin KR, Spies MA
A Single DNA Point Mutation Leads to the Formation of a Cysteine-Tyrosine Crosslink in the Cysteine Dioxygenase from Bacillus subtilis.
1. Biochemistry - published June 7, 2023
2. Schultz RL, Sabat G, Fox BG, Brunold TC
The preference signature of the SARS-CoV-2 Nucleocapsid NTD for its 5'-genomic RNA elements.
1. Nat Commun - published June 7, 2023
2. Korn SM, Dhamotharan K, Jeffries CM, Schlundt A
Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A.
1. Org Biomol Chem - published June 7, 2023
2. Kurup HM, Kvach MV, Harjes S, Jameson GB, Harjes E, Filichev VV
Structures and coordination chemistry of transporters involved in manganese and iron homeostasis.
1. Biochem Soc Trans - published June 7, 2023
2. Ray S, Gaudet R
Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane.
1. Nature - published June 7, 2023
2. Shi W, Cai Y, Zhu H, Peng H, Voyer J, Rits-Volloch S, Cao H, Mayer ML, Song K, Xu C, Lu J, Zhang J, Chen B
Structural biology of an organ.
1. Cell Rep - published June 7, 2023
2. Taylor DW
Plastic recognition and electrogenic uniport translocation of 1(st)-, 2(nd)-, and 3(rd)-row transition and post-transition metals by primary-active transmembrane P(1B-2)-type ATPase pumps.
1. Chem Sci - published June 7, 2023
2. Abeyrathna SS, Abeyrathna NS, Basak P, Irvine GW, Zhang L, Meloni G
Scribble scrambles parathyroid hormone receptor interactions to regulate phosphate and vitamin D homeostasis.
1. Proc Natl Acad Sci U S A - published June 6, 2023
2. Stewart BZ, Mamonova T, Sneddon WB, Javorsky A, Yang Y, Wang B, Nolin TD, Humbert PO, Friedman PA, Kvansakul M
PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers.
1. Proc Natl Acad Sci U S A - published June 6, 2023
2. Hemphill WO, Fenske R, Gooding AR, Cech TR
Structures of Langya Virus Fusion Protein Ectodomain in Pre- and Postfusion Conformation.
1. J Virol - published June 6, 2023
2. May AJ, Pothula KR, Janowska K, Acharya P
A dual, catalytic role for the fission yeast Ccr4-Not complex in gene silencing and heterochromatin spreading.
1. Genetics - published June 6, 2023
2. Challal D, Menant A, Goksal C, Leroy E, Al-Sady B, Rougemaille M
Free ferrous ions sustain activity of mammalian stearoyl-CoA desaturase-1.
1. J Biol Chem - published June 6, 2023
2. Shen J, Wu G, Pierce BS, Tsai AL, Zhou M
A general method for quantitative fractionation of mammalian cells.
1. J Cell Biol - published June 5, 2023
2. Udi Y, Zhang W, Stein ME, Ricardo-Lax I, Pasolli HA, Chait BT, Rout MP
A flexible symbolic regression method for constructing interpretable clinical prediction models.
1. NPJ Digit Med - published June 5, 2023
2. La Cava WG, Lee PC, Ajmal I, Ding X, Solanki P, Cohen JB, Moore JH, Herman DS
Two cold shock domain containing proteins trigger the development of infectious Trypanosoma brucei.
1. PLoS Pathog - published June 5, 2023
2. Toh JY, Nkouawa A, Dong G, Kolev NG, Tschudi C
Author Correction: Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model.
1. NPJ Vaccines - published June 5, 2023
2. Ludwig J, Scally SW, Costa G, Hoffmann S, Murugan R, Lossin J, Prieto K, Obraztsova A, Lobeto N, Franke-Fayard B, Janse CJ, Lebas C, Collin N, Binter S, Kellam P, Levashina EA, Wardemann H, Julien JP
Fluorescent Labeling of RNA and DNA on the Hoogsteen Edge using Sulfinate Chemistry.
1. RNA - published June 5, 2023
2. Bassi T, Hirlinger A, Grayson L, Vantourout J, Toor N
EvdS6 is a bifunctional decarboxylase from the everninomicin gene cluster.
1. J Biol Chem - published June 5, 2023
2. Dulin CC, Sharma P, Frigo L, Voehler MW, Iverson TM, Bachmann BO
RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations.
1. Cancer Discov - published June 4, 2023
2. Subbiah V, Sahai V, Maglic D, Bruderek K, Toure BB, Zhao S, Valverde R, O'Hearn PJ, Moustakas DT, Schonherr H, Gerami-Moayed N, Taylor AM, Hudson BM, Houde DJ, Pal D, Foster L, Gunaydin H, Ayaz P, Sharon DA, Goyal L, Schram AM, Kamath S, Sherwin CA, Schmidt-Kittler O, Jen KY, Ricard F, Wolf BB, Shaw DE, Bergstrom DA, Watters J, Casaletto JB
Correlative light-electron microscopy: integrating dynamics to structure.
1. Trends Biochem Sci - published June 3, 2023
2. Marshall AG, Krystofiak E, Damo SM, Hinton A Jr
Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease.
1. ACS Infect Dis - published June 3, 2023
2. Flynn JM, Huang QYJ, Zvornicanin SN, Schneider-Nachum G, Shaqra AM, Yilmaz NK, Moquin SA, Dovala D, Schiffer CA, Bolon DNA
MDTOMO method for continuous conformational variability analysis in cryo electron subtomograms based on molecular dynamics simulations.
1. Sci Rep - published June 3, 2023
2. Vuillemot R, Rouiller I, Jonić S
Conformation-specific synthetic antibodies discriminate multiple functional states of the ion channel CorA.
1. J Mol Biol - published June 3, 2023
2. Erramilli SK, Dominik PK, Deneka D, Tokarz P, Kim SS, Reddy BG, Skrobek BM, Dalmas O, Perozo E, Kossiakoff AA
Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.
1. Ann Transl Med - published June 3, 2023
2. Rashmi P, Sigdel TK, Rychkov D, Damm I, Da Silva AA, Vincenti F, Lourenco AL, Craik CS, Reiser J, Sarwal MM
Reduced dynamic complexity allows structure elucidation of an excited state of KRAS(G13D).
1. Commun Biol - published June 2, 2023
2. Chao FA, Chan AH, Dharmaiah S, Schwieters CD, Tran TH, Taylor T, Ramakrishnan N, Esposito D, Nissley DV, McCormick F, Simanshu DK, Cornilescu G
30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC.
1. Proc Natl Acad Sci U S A - published June 2, 2023
2. Srinivas P, Nosrati M, Zelinskaya N, Dey D, Comstock LR, Dunham CM, Conn GL
A critical appraisal of the four systematic reviews and meta- analysis on stereotactic body radiation therapy versus external beam radiotherapy for painful bone metastases and where we go from here.
1. Ann Palliat Med - published June 2, 2023
2. Wong HCY, Chan AW, Johnstone P, Simone CB 2nd, Navarro-Domenech I, Hoskin P, Johnstone C, Recht A, Menten J, van der Linden YM, van der Velden JM, Nguyen QN, Lutz S, Andratschke N, Wilmann J, Kazmierska J, Spalek M, Lim F, Yu HM, Perez B, Marta GN, Vassiliou V, Lee SF, Bonomo P, Rembielak A, Chow E, Oldenburger E, Raman S
Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.
1. Protein Sci - published June 2, 2023
2. Gedeon A, Ayoub N, Brûlé S, Raynal B, Karimova G, Gelin M, Mechaly A, Haouz A, Labesse G, Munier-Lehmann H
A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance.
1. mBio - published June 2, 2023
2. Grimes SL, Choi YJ, Banerjee A, Small G, Anderson-Daniels J, Gribble J, Pruijssers AJ, Agostini ML, Abu-Shmais A, Lu X, Darst SA, Campbell E, Denison MR
A conditional gene expression system in Porphyromonas gingivalis for study of the secretion mechanisms of lipoproteins and T9SS cargo proteins.
1. Mol Oral Microbiol - published June 2, 2023
2. Sasaki Y, Shoji M, Sueyoshi T, Shibata S, Matsuo T, Yukitake H, Wolf M, Naito M
Structure-Activity Relationship Study of the High-Affinity Neuropeptide Y(4) Receptor Positive Allosteric Modulator VU0506013.
1. J Med Chem - published June 2, 2023
2. Schüß C, Vu O, Mishra NM, Tough IR, Du Y, Stichel J, Cox HM, Weaver CD, Meiler J, Emmitte KA, Beck-Sickinger AG
Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation.
1. Nat Commun - published June 2, 2023
2. Song R, McAlpine W, Fond AM, Nair-Gill E, Choi JH, Nyström EEL, Arike L, Field S, Li X, SoRelle JA, Moresco JJ, Moresco EMY, Yates JR 3rd, Azadi P, Ni J, Birchenough GMH, Beutler B, Turer EE
Multiple RNA- and DNA-binding proteins exhibit direct transfer of polynucleotides with implications for target-site search.
1. Proc Natl Acad Sci U S A - published June 2, 2023
2. Hemphill WO, Voong CK, Fenske R, Goodrich JA, Cech TR
Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray scattering and cryoelectron microscopy.
1. Proc Natl Acad Sci U S A - published June 2, 2023
2. Watkins MB, Wang H, Burnim A, Ando N
A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein.
1. Proc Natl Acad Sci U S A - published June 2, 2023
2. Thijssen V, Hurdiss DL, Debski-Antoniak OJ, Spence MA, Franck C, Norman A, Aggarwal A, Mokiem NJ, van Dongen DAA, Vermeir SW, Liu M, Li W, Chatziandreou M, Donselaar T, Du W, Drulyte I, Bosch BJ, Snijder J, Turville SG, Payne RJ, Jackson CJ, van Kuppeveld FJM, Jongkees SAK
How to be a GREAT Mentor.
1. Adv Physiol Educ - published June 2, 2023
2. Davis JS, Sakwe AM, Ramesh A, Lindsey ML, Woods L
High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers.
1. Nat Cancer - published June 2, 2023
2. Lin JR, Chen YA, Campton D, Cooper J, Coy S, Yapp C, Tefft JB, McCarty E, Ligon KL, Rodig SJ, Reese S, George T, Santagata S, Sorger PK
NAC controls cotranslational N-terminal methionine excision in eukaryotes.
1. Science - published June 2, 2023
2. Gamerdinger M, Jia M, Schloemer R, Rabl L, Jaskolowski M, Khakzar KM, Ulusoy Z, Wallisch A, Jomaa A, Hunaeus G, Scaiola A, Diederichs K, Ban N, Deuerling E
Engineering Exciton Dynamics with Synthetic DNA Scaffolds.
1. Acc Chem Res - published June 2, 2023
2. Hart SM, Gorman J, Bathe M, Schlau-Cohen GS
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria.
1. Nat Metab - published June 2, 2023
2. Lu KJ, Chang CW, Wang CH, Chen FY, Huang IY, Huang PH, Yang CH, Wu HY, Wu WJ, Hsu KC, Ho MC, Tsai MD, Liao JC
PARP-nucleic acid interactions: Allosteric signaling, PARP inhibitor types, DNA bridges, and viral RNA surveillance.
1. Curr Opin Struct Biol - published June 2, 2023
2. Pascal JM
Sequential apoptotic and multiplexed proteomic evaluation of single cancer cells.
1. Sci Adv - published June 2, 2023
2. Lecky E, Mukherji A, German R, Antonellis G, Lin JR, Yorsz M, McQueeney KE, Ryan J, Ng K, Sicinska E, Sorger PK, Letai A, Bhola PD
Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange.
1. Elife - published June 2, 2023
2. Tippett DN, Breen C, Butler SJ, Sawicka M, Dutzler R
G·U base pairing motifs in long non-coding RNAs.
1. Biochimie - published June 2, 2023
2. Sabalette KB, Makarova L, Marcia M
Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium.
1. Lancet - published June 2, 2023
2. Thakar MS, Logan BR, Puck JM, Dunn EA, Buckley RH, Cowan MJ, O'Reilly RJ, Kapoor N, Satter LF, Pai SY, Heimall J, Chandra S, Ebens CL, Chellapandian D, Williams O, Burroughs LM, Saldana BD, Rayes A, Madden LM, Chandrakasan S, Bednarski JJ 2nd, DeSantes KB, Cuvelier GDE, Teira P, Gillio AP, Eissa H, Knutsen AP, Goldman FD, Aquino VM, Shereck EB, Moore TB, Caywood EH, Lugt MTV, Rozmus J, Broglie L, Yu LC, Shah AJ, Andolina JR, Liu X, Parrott RE, Dara J, Prockop S, Martinez CA, Kapadia M, Jyonouchi SC, Sullivan KE, Bleesing JJ, Chaudhury S, Petrovic A, Keller MD, Quigg TC, Parikh S, Shenoy S, Seroogy C, Rubin T, Decaluwe H, Routes JM, Torgerson TR, Leiding JW, Pulsipher MA, Kohn DB, Griffith LM, Haddad E, Dvorak CC, Notarangelo LD
SARS-CoV-2 protein ORF8 limits expression levels of Spike antigen and facilitates immune evasion of infected host cells.
1. J Biol Chem - published June 2, 2023
2. Kim IJ, Lee YH, Khalid MM, Chen IP, Zhang Y, Ott M, Verdin E
Free Energy Perturbation Calculations of Mutation Effects on SARS-CoV-2 RBD::ACE2 Binding Affinity.
1. J Mol Biol - published June 2, 2023
2. Sergeeva AP, Katsamba PS, Liao J, Sampson JM, Bahna F, Mannepalli S, Morano NC, Shapiro L, Friesner RA, Honig B
Nuclear myosin VI maintains replication fork stability.
1. Nat Commun - published June 2, 2023
2. Shi J, Hauschulte K, Mikicic I, Maharjan S, Arz V, Strauch T, Heidelberger JB, Schaefer JV, Dreier B, Plückthun A, Beli P, Ulrich HD, Wollscheid HP
The HIV-1 capsid core is an opportunistic nuclear import receptor.
1. Nat Commun - published June 2, 2023
2. Xue G, Yu HJ, Buffone C, Huang SW, Lee K, Goh SL, Gres AT, Guney MH, Sarafianos SG, Luban J, Diaz-Griffero F, KewalRamani VN
Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors.
1. Protein Sci - published June 2, 2023
2. Fink EA, Bardine C, Gahbauer S, Singh I, Detomasi T, White K, Gu S, Wan X, Chen J, Ary B, Glenn I, O'Connell J, O'Donnell H, Fajtová P, Lyu J, Vigneron S, Young NJ, Kondratov IS, Alisoltani A, Simons LM, Lorenzo-Redondo R, Ozer EA, Hultquist JF, O'Donoghue AJ, Moroz Y, Taunton J, Renslo AR, Irwin JJ, García-Sastre A, Shoichet BK, Craik CS
Cataract-causing Y204X mutation of crystallin protein CRYβB1 promotes its C-terminal degradation and higher-order oligomerization.
1. J Biol Chem - published June 2, 2023
2. Jing X, Zhu M, Lu X, Wei P, Shi L, Zhang BY, Xu Y, Tang YP, Xiang DM, Gong P
Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-Controlled Trial.
1. Am J Respir Crit Care Med - published June 2, 2023
2. Moskowitz A, Berg KM, Grossestreuer AV, Balaji L, Liu X, Cocchi MN, Chase M, Gong MN, Gong J, Parikh SM, Ngo L, Berlin N, Donnino MW
Ethanol inhibition of undifferentiated rat neural progenitor cell replication can be prevented by chlorogenic acid via the NFATc4/CSE signalling pathway.
1. Alcohol (Hanover) - published June 2, 2023
2. Shanmugam S, Patel D, Rodriguez AL, Walchale A, Liu X, Bergeson SE, Mahimainathan L, Narasimhan M, Henderson GI
D-amino acids signal a stress-dependent run-away response in Vibrio cholerae.
1. Nat Microbiol - published June 2, 2023
2. Irazoki O, Ter Beek J, Alvarez L, Mateus A, Colin R, Typas A, Savitski MM, Sourjik V, Berntsson RP, Cava F
Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria.
1. Hum Mol Genet - published June 2, 2023
2. Lucienne M, Gerlini R, Rathkolb B, Calzada-Wack J, Forny P, Wueest S, Kaech A, Traversi F, Forny M, Bürer C, Aguilar-Pimentel A, Irmler M, Beckers J, Sauer S, Kölker S, Dewulf JP, Bommer GT, Hoces D, Gailus-Durner V, Fuchs H, Rozman J, Froese DS, Baumgartner MR, de Angelis MH
A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy.
1. Mol Cell - published June 2, 2023
2. Townley BA, Buerer L, Tsao N, Bacolla A, Mansoori F, Rusanov T, Clark N, Goodarzi N, Schmidt N, Srivatsan SN, Sun H, Sample RA, Brickner JR, McDonald D, Tsai MS, Walter MJ, Wozniak DF, Holehouse AS, Pena V, Tainer JA, Fairbrother WG, Mosammaparast N
CBASS to cGAS-STING: The Origins and Mechanisms of Nucleotide Second Messenger Immune Signaling.
1. Annu Rev Virol - published June 2, 2023
2. Slavik KM, Kranzusch PJ
cGLRs are a diverse family of pattern recognition receptors in innate immunity.
1. Cell - published June 2, 2023
2. Li Y, Slavik KM, Toyoda HC, Morehouse BR, de Oliveira Mann CC, Elek A, Levy S, Wang Z, Mears KS, Liu J, Kashin D, Guo X, Mass T, Sebé-Pedrós A, Schwede F, Kranzusch PJ
Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice.
1. Sci Transl Med - published June 2, 2023
2. Mathiesen BK, Miyakoshi LM, Cederroth CR, Tserga E, Versteegh C, Bork PAR, Hauglund NL, Gomolka RS, Mori Y, Edvall NK, Rouse S, Møllgård K, Holt JR, Nedergaard M, Canlon B
Defining the Roles of Pyruvate Oxidation, TCA Cycle, and Mannitol Metabolism in Methicillin-Resistant Staphylococcus aureus Catheter-Associated Urinary Tract Infection.
1. Microbiol Spectr - published June 2, 2023
2. Paudel S, Guedry S, Obernuefemann CLP, Hultgren SJ, Walker JN, Kulkarni R
Fanzor is a eukaryotic programmable RNA-guided endonuclease.
1. Nature - published June 2, 2023
2. Saito M, Xu P, Faure G, Maguire S, Kannan S, Altae-Tran H, Vo S, Desimone A, Macrae RK, Zhang F
Phase separation of FSP1 promotes ferroptosis.
1. Nature - published June 2, 2023
2. Nakamura T, Hipp C, Santos Dias Mourão A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M
Advances in Structural Virology via Cryo-EM in 2022.
1. Viruses - published June 2, 2023
2. Schoehn G, Chenavier F, Crépin T
Structural biology: A golden era.
1. PLoS Biol - published June 2, 2023
2. Carugo O, Djinović-Carugo K
Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling.
1. Science - published June 2, 2023
2. Zhang M, Jungblut A, Kunert F, Hauptmann L, Hoffmann T, Kolesnikova O, Metzner F, Moldt M, Weis F, DiMaio F, Hopfner KP, Eustermann S
Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility.
1. Science - published June 2, 2023
2. Wu H, Muñoz EN, Hsieh LJ, Chio US, Gourdet MA, Narlikar GJ, Cheng Y
Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis.
1. Nat Genet - published June 2, 2023
2. Tenney AP, Di Gioia SA, Webb BD, Chan WM, de Boer E, Garnai SJ, Barry BJ, Ray T, Kosicki M, Robson CD, Zhang Z, Collins TE, Gelber A, Pratt BM, Fujiwara Y, Varshney A, Lek M, Warburton PE, Van Ryzin C, Lehky TJ, Zalewski C, King KA, Brewer CC, Thurm A, Snow J, Facio FM, Narisu N, Bonnycastle LL, Swift A, Chines PS, Bell JL, Mohan S, Whitman MC, Staffieri SE, Elder JE, Demer JL, Torres A, Rachid E, Al-Haddad C, Boustany RM, Mackey DA, Brady AF, Fenollar-Cortés M, Fradin M, Kleefstra T, Padberg GW, Raskin S, Sato MT, Orkin SH, Parker SCJ, Hadlock TA, Vissers LELM, van Bokhoven H, Jabs EW, Collins FS, Pennacchio LA, Manoli I, Engle EC
Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
1. Mol Cell - published June 2, 2023
2. Zhang J, Zeng W, Han Y, Lee WR, Liou J, Jiang Y
A conserved tryptophan in the acylated segment of RTX toxins controls their β(2)- integrin-independent cell penetration.
1. J Biol Chem - published June 2, 2023
2. Osickova A, Knoblochova S, Bumba L, Man P, Kalaninova Z, Lepesheva A, Jurnecka D, Cizkova M, Biedermannova L, Goldsmith JA, Maynard JA, McLellan JS, Osicka R, Sebo P, Masin J
Human Cytochrome P450 3A7 Binding Four Copies of Its Native Substrate Dehydroepiandrosterone 3-Sulfate.
1. J Biol Chem - published June 2, 2023
2. Liu J, Kandel SE, Lampe JN, Scott EE
Modeling conformational states of proteins with AlphaFold.
1. Curr Opin Struct Biol - published June 2, 2023
2. Sala D, Engelberger F, Mchaourab HS, Meiler J
Molecular basis of inherited protein C deficiency results from genetic variations in the signal peptide and propeptide regions.
1. J Thromb Haemost - published June 2, 2023
2. Cao Q, Hao Z, Li C, Chen X, Gao M, Jiang N, Liu H, Shen Y, Yang H, Zhang S, Yang A, Li W, Tie JK, Shen G
Oncogenic K-Ras suppresses global miRNA function.
1. Mol Cell - published June 2, 2023
2. Shui B, Beyett TS, Chen Z, Li X, La Rocca G, Gazlay WM, Eck MJ, Lau KS, Ventura A, Haigis KM
Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template.
1. Eur J Med Chem - published June 2, 2023
2. Marciniak M, Mróz P, Napolitano V, Kalel VC, Fino R, Pykacz E, Schliebs W, Plettenburg O, Erdmann R, Sattler M, Popowicz GM, Dawidowski M
Substitution of PINK1 Gly411 modulates substrate receptivity and turnover.
1. Autophagy - published June 1, 2023
2. Fiesel FC, Fričová D, Hayes CS, Coban MA, Hudec R, Bredenberg JM, Broadway BJ, Markham BN, Yan T, Boneski PK, Fiorino G, Watzlawik JO, Hou X, McCarty AM, Lewis-Tuffin LJ, Zhong J, Madden BJ, Ordureau A, An H, Puschmann A, Wszolek ZK, Ross OA, Harper JW, Caulfield TR, Springer W
Oaks to arteries: the Physiology Core Concept of flow down gradients supports transfer of student reasoning.
1. Adv Physiol Educ - published June 1, 2023
2. Doherty JH, Cerchiara JA, Scott EE, Jescovitch LN, McFarland JL, Haudek KC, Wenderoth MP
What a Difference in Pressure Makes! A Framework Describing Undergraduate Students' Reasoning about Bulk Flow Down Pressure Gradients.
1. CBE Life Sci Educ - published June 1, 2023
2. Doherty JH, Scott EE, Cerchiara JA, Jescovitch LN, McFarland JL, Haudek KC, Wenderoth MP
Prevalence and Homology of the Pneumococcal Serine-Rich Repeat Protein at the Global Scale.
1. Microbiol Spectr - published June 1, 2023
2. Aceil J, Venkat A, Pan E, Kannan N, Avci FY
Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma.
1. Life Sci Alliance - published June 1, 2023
2. Panizza E, Regalado BD, Wang F, Nakano I, Vacanti NM, Cerione RA, Antonyak MA
Therapeutic disruption of RAD52-ssDNA complexation via novel drug-like inhibitors.
1. NAR Cancer - published June 1, 2023
2. Bhat DS, Malacaria E, Biagi LD, Razzaghi M, Honda M, Hobbs KF, Hengel SR, Pichierri P, Spies MA, Spies M
The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling.
1. J Biol Chem - published June 1, 2023
2. Lopez J, Bonsor DA, Sale MJ, Urisman A, Mehalko JL, Cabanski-Dunning M, Castel P, Simanshu DK, McCormick F
Engaging adults in organized physical activity: a scoping review of recruitment strategies.
1. Health Promot Int - published June 1, 2023
2. Mackenzie-Stewart R, de Lacy-Vawdon C, Murphy N, Smith BJ
Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand.
1. Nat Struct Mol Biol - published June 1, 2023
2. Chauvier A, Porta JC, Deb I, Ellinger E, Meze K, Frank AT, Ohi MD, Walter NG
Structural interplay of anesthetics and paralytics on muscle nicotinic receptors.
1. Nat Commun - published June 1, 2023
2. Goswami U, Rahman MM, Teng J, Hibbs RE
Prognostic value of early PET in patients with large B-cell lymphoma treated with anti-CD19 CAR T-cell therapy.
1. Haematologica - published June 1, 2023
2. Crombie JL, Jacobson CA, Redd R, Shouse G, Herrera AF, Chow VA, Gauthier J, Mullane E, Cahill K, Kline J, Romancik J, Cohen JB, Saucier A, Houot R, Armand P, Hess B
A Dual-Targeting Liposome Enhances Triple-Negative Breast Cancer Chemoimmunotherapy through Inducing Immunogenic Cell Death and Inhibiting STAT3 Activation.
1. Small - published June 1, 2023
2. Luo K, Yang L, Yan C, Zhao Y, Li Q, Liu X, Xie L, Sun Q, Li X
Repair and tolerance of DNA damage at the replication fork: A structural perspective.
1. Curr Opin Struct Biol - published June 1, 2023
2. Eichman BF
The Transposon-Encoded Protein TnpB Processes Its Own mRNA into ωRNA for Guided Nuclease Activity.
1. CRISPR J - published June 1, 2023
2. Nety SP, Altae-Tran H, Kannan S, Demircioglu FE, Faure G, Hirano S, Mears K, Zhang Y, Macrae RK, Zhang F
A specialized integrin-binding motif enables proTGF-β2 activation by integrin αVβ6 but not αVβ8.
1. Proc Natl Acad Sci U S A - published June 1, 2023
2. Le VQ, Zhao B, Ramesh S, Toohey C, DeCosta A, Mintseris J, Liu X, Gygi S, Springer TA
Development of an in vitro method for activation of X-succinate synthases for fumarate hydroalkylation.
1. iScience - published June 1, 2023
2. Andorfer MC, King-Roberts DT, Imrich CN, Brotheridge BG, Drennan CL
Allosteric activation of cell wall synthesis during bacterial growth.
1. Nat Commun - published June 1, 2023
2. Shlosman I, Fivenson EM, Gilman MSA, Sisley TA, Walker S, Bernhardt TG, Kruse AC, Loparo JJ
Transient water wires mediate selective proton transport in designed channel proteins.
1. Nat Chem - published June 1, 2023
2. Kratochvil HT, Watkins LC, Mravic M, Thomaston JL, Nicoludis JM, Somberg NH, Liu L, Hong M, Voth GA, DeGrado WF
The aflatoxin B(1) -induced imidazole ring-opened guanine adduct: high mutagenic potential that is minimally affected by sequence context.
1. Environ Mol Mutagen - published June 1, 2023
2. Minko IG, Kellum AH Jr, Stone MP, Lloyd RS
Conformational change of Plasmodium TRAP is essential for sporozoite migration and transmission.
1. EMBO Rep - published June 1, 2023
2. Braumann F, Klug D, Kehrer J, Song G, Feng J, Springer TA, Frischknecht F
Mechanism of D-alanine transfer to teichoic acids shows how bacteria acylate cell envelope polymers.
1. Nat Microbiol - published June 1, 2023
2. Schultz BJ, Snow ED, Walker S
Molecular Mechanism of Nucleosome Recognition by the Pioneer Transcription Factor Sox.
1. J Chem Inf Model - published June 1, 2023
2. Ozden B, Boopathi R, Barlas AB, Lone IN, Bednar J, Petosa C, Kale S, Hamiche A, Angelov D, Dimitrov S, Karaca E
Activity, substrate preference and structure of the HsMCM8/9 helicase.
1. Nucleic Acids Res - published June 1, 2023
2. McKinzey DR, Li C, Gao Y, Trakselis MA
Decrypting Integrins by Mixed-Solvent Molecular Dynamics Simulations.
1. J Chem Inf Model - published June 1, 2023
2. Ilie IM, Ehrhardt C, Caflisch A, Weitz-Schmidt G
Orthogonal translation with 5-cyanotryptophan as an infrared probe for local structural information, electrostatics, and hydrogen bonding.
1. Protein Sci - published June 1, 2023
2. Freiherr von Sass JG, Blain-Hartung M, Baumann T, Forest KT, Hildebrandt P, Budisa N
Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody.
1. Sci Transl Med - published June 1, 2023
2. Mittler E, Serris A, Esterman ES, Florez C, Polanco LC, O'Brien CM, Slough MM, Tynell J, Gröning R, Sun Y, Abelson DM, Wec AZ, Haslwanter D, Keller M, Ye C, Bakken RR, Jangra RK, Dye JM, Ahlm C, Rappazzo CG, Ulrich RG, Zeitlin L, Geoghegan JC, Bradfute SB, Sidoli S, Forsell MNE, Strandin T, Rey FA, Herbert AS, Walker LM, Chandran K, Guardado-Calvo P
Rescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F.
1. Mol Ther - published June 1, 2023
2. Peters CW, Hanlon KS, Ivanchenko MV, Zinn E, Linarte EF, Li Y, Levy JM, Liu DR, Kleinstiver BP, Indzhykulian AA, Corey DP
Mechanistic basis for potent neutralization of Sin Nombre hantavirus by a human monoclonal antibody.
1. Nat Microbiol - published June 1, 2023
2. Stass R, Engdahl TB, Chapman NS, Wolters RM, Handal LS, Diaz SM, Crowe JE Jr, Bowden TA
Bacterial meningitis in the early postnatal mouse studied at single-cell resolution.
1. Elife - published June 1, 2023
2. Wang J, Rattner A, Nathans J
Molecular mechanisms of Holliday junction branch migration catalyzed by an asymmetric RuvB hexamer.
1. Nat Commun - published June 1, 2023
2. Rish AD, Shen Z, Chen Z, Zhang N, Zheng Q, Fu TM
Teraryl Braces in Macrocycles: Synthesis and Conformational Landscape Remodeling of Peptides.
1. J Am Chem Soc - published June 1, 2023
2. Yang P, Širvinskas MJ, Li B, Heller NW, Rong H, He G, Yudin AK, Chen G
Comparison of Activity, Structure, and Dynamics of SF-1 and LRH-1 Complexed with Small Molecule Modulators.
1. J Biol Chem - published June 1, 2023
2. Cato ML, D'Agostino EH, Spurlin RM, Flynn AR, Cornelison JL, Johnson AM, Fujita RA, Abraham SM, Jui NT, Ortlund EA
Structural specializations of the sperm tail.
1. Cell - published June 1, 2023
2. Leung MR, Zeng J, Wang X, Roelofs MC, Huang W, Zenezini Chiozzi R, Hevler JF, Heck AJR, Dutcher SK, Brown A, Zhang R, Zeev-Ben-Mordehai T
Genotype-Phenotype Correlations in TMPRSS3 (DFNB10/DFNB8) with Emphasis on Natural History.
1. Audiol Neurootol - published June 1, 2023
2. Nisenbaum E, Yan D, Shearer AE, de Joya E, Thielhelm T, Russell N, Staecker H, Chen Z, Holt JR, Liu X
Modulating antibody effector functions by Fc glycoengineering.
1. Biotechnol Adv - published June 1, 2023
2. García-Alija M, van Moer B, Sastre DE, Azzam T, Du JJ, Trastoy B, Callewaert N, Sundberg EJ, Guerin ME
Multicellular communities are perturbed in the aging human brain and Alzheimer's disease.
1. Nat Neurosci - published June 1, 2023
2. Cain A, Taga M, McCabe C, Green GS, Hekselman I, White CC, Lee DI, Gaur P, Rozenblatt-Rosen O, Zhang F, Yeger-Lotem E, Bennett DA, Yang HS, Regev A, Menon V, Habib N, De Jager PL
Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3.
1. Nat Commun - published June 1, 2023
2. Torosyan H, Paul MD, Forget A, Lo M, Diwanji D, Pawłowski K, Krogan NJ, Jura N, Verba KA
PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems.
1. EMBO Rep - published June 1, 2023
2. Kraus F, Goodall EA, Smith IR, Jiang Y, Paoli JC, Adolf F, Zhang J, Paulo JA, Schulman BA, Harper JW
A structural blueprint for interleukin-21 signal modulation.
1. Cell Rep - published June 1, 2023
2. Abhiraman GC, Bruun TUJ, Caveney NA, Su LL, Saxton RA, Yin Q, Tang S, Davis MM, Jude KM, Garcia KC
Bringing GPCR Structural Biology to Medical Applications: Insights from Both V2 Vasopressin and Mu-Opioid Receptors.
1. Membranes (Basel) - published June 1, 2023
2. Fouillen A, Bous J, Granier S, Mouillac B, Sounier R
Molecular basis of RanGTP-activated release of Histones H2A-H2B from Importin-9.
1. Structure - published June 1, 2023
2. Shaffer JM, Jiou J, Tripathi K, Olaluwoye OS, Fung HYJ, Chook YM, D'Arcy S
In Silico Identification and In Vitro Validation of Repurposed Compounds Targeting the RSV Polymerase.
1. Microorganisms - published June 1, 2023
2. Xu E, Park S, Calderon J, Cao D, Liang B
Single-Molecule Analysis of the Improved Variants of the G-Quadruplex Recognition Protein G4P.
1. Int J Mol Sci - published June 1, 2023
2. Gaur P, Bain FE, Honda M, Granger SL, Spies M
Analyzing the Geometry and Dynamics of Viral Structures: A Review of Computational Approaches Based on Alpha Shape Theory, Normal Mode Analysis, and Poisson-Boltzmann Theories.
1. Viruses - published June 1, 2023
2. Hsieh YC, Delarue M, Orland H, Koehl P