Member Publications

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124 Member Publications for December 2022

Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings.
1. Front Immunol - published December 30, 2022
2. Boswell KL, Watkins TA, Cale EM, Samsel J, Andrews SF, Ambrozak DR, Driscoll JI, Messina MA, Narpala S, Hopp CS, Cagigi A, Casazza JP, Yamamoto T, Zhou T, Schief WR, Crompton PD, Ledgerwood JE, Connors M, Gama L, Kwong PD, McDermott A, Mascola JR, Koup RA
Histone variants and chromatin structure, update of advances.
1. Comput Struct Biotechnol J - published December 30, 2022
2. Sokolova V, Sarkar S, Tan D
Evidence of Chronic Complement Activation in Asymptomatic Pediatric Brain Injury Patients: A Pilot Study.
1. Children (Basel) - published December 26, 2022
2. Holmes SA, Mar'i J, Lemme J, Maallo AM, Lebel A, Simons L, O'Brien MJ, Zurakowski D, Burnstein R, Borsook D
Characterization of a novel positive allosteric modulator of the α(1A)-Adrenergic receptor.
1. Curr Res Pharmacol Drug Discov - published December 22, 2022
2. Papay RS, Macdonald JD, Stauffer SR, Perez DM
No magic bullet: Limiting in-school transmission in the face of variable SARS-CoV-2 viral loads.
1. Front Public Health - published December 19, 2022
2. Van Egeren D, Stoddard M, Malakar A, Ghosh D, Acharya A, Mainuddin S, Majumdar B, Luo D, Nolan RP, Joseph-McCarthy D, White LF, Hochberg NS, Basu S, Chakravarty A
Changes of bacterial and fungal communities and relationship between keystone taxon and physicochemical factors during dairy manure ectopic fermentation.
1. PLoS One - published December 19, 2022
2. Gong P, Gao D, Hu X, Tan J, Wu L, Liu W, Yang Y, Jin E
Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity.
1. PLoS One - published December 15, 2022
2. Heintz MM, Eccles JA, Olack EM, Maner-Smith KM, Ortlund EA, Baldwin WS
Analyzing PARP1 Activity: Small Molecule Reactants and Attached Chains of Poly (ADP-Ribose).
1. Methods Mol Biol - published December 14, 2022
2. Rudolph J, Luger K
Rosetta FlexPepDock to predict peptide-MHC binding: An approach for non-canonical amino acids.
1. PLoS One - published December 13, 2022
2. Bloodworth N, Barbaro NR, Moretti R, Harrison DG, Meiler J
Cell polarity signalling at the birth of multicellularity: What can we learn from the first animals.
1. Front Cell Dev Biol - published December 12, 2022
2. Wright BA, Kvansakul M, Schierwater B, Humbert PO
Selective posttranslational inhibition of Ca(V)β(1)-associated voltage-dependent calcium channels with a functionalized nanobody.
1. Nat Commun - published December 9, 2022
2. Morgenstern TJ, Nirwan N, Hernández-Ochoa EO, Bibollet H, Choudhury P, Laloudakis YD, Ben Johny M, Bannister RA, Schneider MF, Minor DL Jr, Colecraft HM
Structure of the AlgKX modification and secretion complex required for alginate production and biofilm attachment in Pseudomonas aeruginosa.
1. Nat Commun - published December 9, 2022
2. Gheorghita AA, Li YE, Kitova EN, Bui DT, Pfoh R, Low KE, Whitfield GB, Walvoort MTC, Zhang Q, Codée JDC, Klassen JS, Howell PL
Analyses of Cullin1 homologs reveal functional redundancy in S-RNase-based self-incompatibility and evolutionary relationships in eudicots.
1. Plant Cell - published December 8, 2022
2. Sun L, Cao S, Zheng N, Kao TH
A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair.
1. Nucleic Acids Res - published December 8, 2022
2. Bralić A, Tehseen M, Sobhy MA, Tsai CL, Alhudhali L, Yi G, Yu J, Yan C, Ivanov I, Tsutakawa SE, Tainer JA, Hamdan SM
Crystal structure of a pre-chemistry viral RNA-dependent RNA polymerase suggests participation of two basic residues in catalysis.
1. Nucleic Acids Res - published December 8, 2022
2. Li R, Wang M, Gong P
Variants in CLDN5 cause a syndrome characterized by seizures, microcephaly and brain calcifications.
1. Brain - published December 8, 2022
2. Deshwar AR, Cytrynbaum C, Murthy H, Zon J, Chitayat D, Volpatti J, Newbury-Ecob R, Ellard S, Lango Allen H, Yu EP, Noche R, Walker S, Scherer SW, Mahida S, Elitt CM, Nicolas G, Goldenberg A, Saugier-Veber P, Lecoquierre F, Dabaj I, Meddaugh H, Marble M, Keppler-Noreuil KM, Drayson L, Barañano KW, Chassevent A, Agre K, Létard P, Bilan F, Le Guyader G, Laquerrière A, Ramsey K, Henderson L, Brady L, Tarnopolsky M, Bainbridge M, Friedman J, Capri Y, Athayde L, Kok F, Gurgel-Giannetti J, Ramos LLP, Blaser S, Dowling JJ, Weksberg R
The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3.
1. Nucleic Acids Res - published December 8, 2022
2. Hall D, Giaimo BD, Park SS, Hemmer W, Friedrich T, Ferrante F, Bartkuhn M, Yuan Z, Oswald F, Borggrefe T, Rual JF, Kovall RA
Establishment of a diverse head and neck squamous cancer cell bank using conditional reprogramming culture methods.
1. J Med Virol - published December 8, 2022
2. Li D, Thomas C, Shrivastava N, Gersten A, Gadsden N, Schlecht N, Kawachi N, Schiff BA, Smith RV, Rosenblatt G, Augustine S, Gavathiotis E, Burk R, Prystowsky MB, Guha C, Mehta V, Ow TJ
The TRAPP Complexes: Discriminating GTPases in Context.
1. FEBS Lett - published December 8, 2022
2. Bagde SR, Fromme JC
Principles of mitoribosomal small subunit assembly in eukaryotes.
1. Nature - published December 8, 2022
2. Harper NJ, Burnside C, Klinge S
A broad specificity β-propeller enzyme from Rhodopseudomonas palustris that hydrolyzes many lactones including γ-valerolactone.
1. J Biol Chem - published December 8, 2022
2. Hall BW, Bingman CA, Fox BG, Noguera DR, Donohue TJ
Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
1. ACS Med Chem Lett - published December 8, 2022
2. Heppner DE, Wittlinger F, Beyett TS, Shaurova T, Urul DA, Buckley B, Pham CD, Schaeffner IK, Yang B, Ogboo BC, May EW, Schaefer EM, Eck MJ, Laufer SA, Hershberger PA
A network of mixed actin polarity in the leading edge of spreading cells.
1. Commun Biol - published December 7, 2022
2. Chung WL, Eibauer M, Li W, Boujemaa-Paterski R, Geiger B, Medalia O
Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis.
1. Elife - published December 7, 2022
2. Schwager SC, Young K, Hapach LA, Carlson CM, Mosier JA, McArdle TJ, Wang W, Schunk C, Jayathilake AL, Bates ME, Bordeleau F, Antonyak MA, Cerione RA, Reinhart-King CA
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth.
1. Elife - published December 7, 2022
2. Costantino L, Ferrari S, Santucci M, Salo-Ahen OMH, Carosati E, Franchini S, Lauriola A, Pozzi C, Trande M, Gozzi G, Saxena P, Cannazza G, Losi L, Cardinale D, Venturelli A, Quotadamo A, Linciano P, Tagliazucchi L, Moshella MG, Guerrini R, Pacifico S, Luciani R, Genovese F, Henrich S, Alboni S, Santarem N, da Silva Cordeiro A, Giovannetti E, Peters GJ, Pinton P, Rimessi A, Cruciani G, Stroud RM, Wade RC, Mangani S, Marverti G, D'Arca D, Ponterini G, Paola Costi M
An in silico method to assess antibody fragment polyreactivity.
1. Nat Commun - published December 7, 2022
2. Harvey EP, Shin JE, Skiba MA, Nemeth GR, Hurley JD, Wellner A, Shaw AY, Miranda VG, Min JK, Liu CC, Marks DS, Kruse AC
Computational epitope mapping of class I fusion proteins using low complexity supervised learning methods.
1. PLoS Comput Biol - published December 7, 2022
2. Fischer MFS, Crowe JE, Meiler J
Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
1. Nature - published December 7, 2022
2. Yang X, Garner LI, Zvyagin IV, Paley MA, Komech EA, Jude KM, Zhao X, Fernandes RA, Hassman LM, Paley GL, Savvides CS, Brackenridge S, Quastel MN, Chudakov DM, Bowness P, Yokoyama WM, McMichael AJ, Gillespie GM, Garcia KC
DNA damage independent inhibition of NF-kB transcription by anthracyclines.
1. Elife - published December 7, 2022
2. Chora AF, Pedroso D, Kyriakou E, Pejanovic N, Colaço H, Gozzelino R, Barros A, Willmann K, Velho TR, Moita C, Santos I, Pereira P, Carvalho S, Martins FB, Ferreira JA, de Almeida SF, Benes V, Anrather J, Weis S, Soares MP, Geerlof A, Neefjes J, Sattler M, Messias AC, Neves Costa A, Moita LF
Mitochondrial dynamics proteins as emerging drug targets.
1. Trends Pharmacol Sci - published December 7, 2022
2. Zacharioudakis E, Gavathiotis E
Surface electrostatics dictate RNA-binding protein CAPRIN1 condensate concentration and hydrodynamic properties.
1. J Biol Chem - published December 7, 2022
2. Toyama Y, Rangadurai AK, Forman-Kay JD, Kay LE
Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.
1. bioRxiv - published December 7, 2022
2. Oâ Meara TR, Nanishi E, McGrath ME, Barman S, Dong D, Dillen C, Menon M, Seo HS, Dhe-Paganon S, Ernst RK, Levy O, Frieman MB, Dowling DJ
Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination.
1. Nature - published December 6, 2022
2. Schaefer-Babajew D, Wang Z, Muecksch F, Cho A, Loewe M, Cipolla M, Raspe R, Johnson B, Canis M, DaSilva J, Ramos V, Turroja M, Millard KG, Schmidt F, Witte L, Dizon J, Shimelovich I, Yao KH, Oliveira TY, Gazumyan A, Gaebler C, Bieniasz PD, Hatziioannou T, Caskey M, Nussenzweig MC
Machine Learning Modeling of Protein-intrinsic Features Predicts Tractability of Targeted Protein Degradation.
1. Genomics Proteomics Bioinformatics - published December 6, 2022
2. Zhang W, Roy Burman SS, Chen J, Donovan KA, Cao Y, Shu C, Zhang B, Zeng Z, Gu S, Zhang Y, Li D, Fischer ES, Tokheim C, Shirley Liu X
A rapid RIG-I signaling relay mediates efficient antiviral response.
1. Mol Cell - published December 6, 2022
2. Thoresen DT, Galls D, Götte B, Wang W, Pyle AM
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans.
1. J Exp Med - published December 5, 2022
2. Wang Z, Zhou P, Muecksch F, Cho A, Ben Tanfous T, Canis M, Witte L, Johnson B, Raspe R, Schmidt F, Bednarski E, Da Silva J, Ramos V, Zong S, Turroja M, Millard KG, Yao KH, Shimeliovich I, Dizon J, Kaczynska A, Jankovic M, Gazumyan A, Oliveira TY, Caskey M, Gaebler C, Bieniasz PD, Hatziioannou T, Nussenzweig MC
Mitoguardin-2-mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation.
1. J Cell Biol - published December 5, 2022
2. Hong Z, Adlakha J, Wan N, Guinn E, Giska F, Gupta K, Melia TJ, Reinisch KM
Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS.
1. J Cell Biol - published December 5, 2022
2. Kono Y, Adam SA, Sato Y, Reddy KL, Zheng Y, Medalia O, Goldman RD, Kimura H, Shimi T
Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States.
1. mBio - published December 5, 2022
2. Benjamin B, Goldgur Y, Jork N, Jessen HJ, Schwer B, Shuman S
Editorial: Molecular chaperones and human disease.
1. Front Mol Biosci - published December 5, 2022
2. Chakafana G, Makumire S, Makhoba XH
Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.
1. Nat Commun - published December 5, 2022
2. Zhang L, Simonsen C, Zimova L, Wang K, Moparthi L, Gaudet R, Ekoff M, Nilsson G, Hellmich UA, Vlachova V, Gourdon P, Zygmunt PM
Acetophenone protection against cisplatin-induced end-organ damage.
1. Transl Oncol - published December 5, 2022
2. Geohagen B, Zeldin E, Reidy K, Wang T, Gavathiotis E, Fishman YI, LoPachin R, Loeb DM, Weiser DA
Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.
1. Cell Chem Biol - published December 5, 2022
2. Arnold MR, Langelier MF, Gartrell J, Kirby IT, Sanderson DJ, Bejan DS, Šileikytė J, Sundalam SK, Nagarajan S, Marimuthu P, Duell AK, Shelat AA, Pascal JM, Cohen MS
Single-molecule characterization of subtype-specific β1 integrin mechanics.
1. Nat Commun - published December 3, 2022
2. Jo MH, Li J, Jaumouillé V, Hao Y, Coppola J, Yan J, Waterman CM, Springer TA, Ha T
Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA.
1. Nucleic Acids Res - published December 3, 2022
2. Keil P, Wulf A, Kachariya N, Reuscher S, Hühn K, Silbern I, Altmüller J, Keller M, Stehle R, Zarnack K, Sattler M, Urlaub H, Sträßer K
Kinetics of elementary steps in loop-mediated isothermal amplification (LAMP) show that strand invasion during initiation is rate-limiting.
1. Nucleic Acids Res - published December 3, 2022
2. Dangerfield TL, Paik I, Bhadra S, Johnson KA, Ellington AD
Innate Immune Stimulation Using 3D Wireframe DNA Origami.
1. ACS Nano - published December 2, 2022
2. Du RR, Cedrone E, Romanov A, Falkovich R, Dobrovolskaia MA, Bathe M
Activation of IL1 signaling molecules by Kaposi's sarcoma-associated herpesvirus.
1. Front Cell Infect Microbiol - published December 2, 2022
2. Chen J, Song J, James J, Plaisance-Bonstaff K, Post SR, Qin Z, Dai L
Identification, binding, and structural characterization of single domain anti-PD-L1 antibodies inhibitory of immune regulatory proteins PD-1 and CD80.
1. J Biol Chem - published December 2, 2022
2. Kang-Pettinger T, Walker K, Brown R, Cowan R, Wright H, Baravalle R, Waters LC, Muskett FW, Bowler MW, Sawmynaden K, Coombs PJ, Carr MD, Hall G
Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
1. Nat Commun - published December 2, 2022
2. Blair K, Tehseen M, Raducanu VS, Shahid T, Lancey C, Rashid F, Creuhet R, Hamdan SM, De Biasio A
Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions.
1. Nucleic Acids Res - published December 2, 2022
2. Malki I, Liepina I, Kogelnik N, Watmuff H, Robinson S, Lightfoot A, Gonchar O, Bottrill A, Fry AM, Dominguez C
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.
1. Science - published December 2, 2022
2. Lee D, Le Pen J, Yatim A, Dong B, Aquino Y, Ogishi M, Pescarmona R, Talouarn E, Rinchai D, Zhang P, Perret M, Liu Z, Jordan I, Elmas Bozdemir S, Bayhan GI, Beaufils C, Bizien L, Bisiaux A, Lei W, Hasan M, Chen J, Gaughan C, Asthana A, Libri V, Luna JM, Jaffré F, Hoffmann HH, Michailidis E, Moreews M, Seeleuthner Y, Bilguvar K, Mane S, Flores C, Zhang Y, Arias AA, Bailey R, Schlüter A, Milisavljevic B, Bigio B, Le Voyer T, Materna M, Gervais A, Moncada-Velez M, Pala F, Lazarov T, Levy R, Neehus AL, Rosain J, Peel J, Chan YH, Morin MP, Pino-Ramirez RM, Belkaya S, Lorenzo L, Anton J, Delafontaine S, Toubiana J, Bajolle F, Fumadó V, DeDiego ML, Fidouh N, Rozenberg F, Pérez-Tur J, Chen S, Evans T, Geissmann F, Lebon P, Weiss SR, Bonnet D, Duval X, CoV-Contact Cohort§, Covid HGE, Pan-Hammarström Q, Planas AM, Meyts I, Haerynck F, Pujol A, Sancho-Shimizu V, Dalgard C, Bustamante J, Puel A, Boisson-Dupuis S, Boisson B, Maniatis T, Zhang Q, Bastard P, Notarangelo L, Béziat V, Perez de Diego R, Rodriguez-Gallego C, Su HC, Lifton RP, Jouanguy E, Cobat A, Alsina L, Keles S, Haddad E, Abel L, Belot A, Quintana-Murci L, Rice CM, Silverman RH, Zhang SY, Casanova JL
Morphological control enables nanometer-scale dissection of cell-cell signaling complexes.
1. Nat Commun - published December 2, 2022
2. Dow LP, Gaietta G, Kaufman Y, Swift MF, Lemos M, Lane K, Hopcroft M, Bezault A, Sauvanet C, Volkmann N, Pruitt BL, Hanein D
Actin cytoskeleton and complex cell architecture in an Asgard archaeon.
1. Nature - published December 2, 2022
2. Rodrigues-Oliveira T, Wollweber F, Ponce-Toledo RI, Xu J, Rittmann SKR, Klingl A, Pilhofer M, Schleper C
Multi-micron crisscross structures grown from DNA-origami slats.
1. Nat Nanotechnol - published December 2, 2022
2. Wintersinger CM, Minev D, Ershova A, Sasaki HM, Gowri G, Berengut JF, Corea-Dilbert FE, Yin P, Shih WM
The tetraspanin CD53 protects stressed hematopoietic stem cells via promotion of DREAM complex- mediated quiescence.
1. Blood - published December 2, 2022
2. Greenberg ZJ, Monlish D, Chiquetto Paracatu L, Dong Q, Rettig MP, Roundy ND, Gaballa R, Li W, Yang W, Luke CJ, Schuettpelz L
The mitotic role of Adenomatous Polyposis Coli requires its bilateral interaction with tubulin and microtubules.
1. J Cell Sci - published December 2, 2022
2. Serre L, Delaroche J, Vinit A, Schoehn G, Denarier E, Fourest-Lieuvin A, Arnal I
Multilayered allosteric modulation of coupled folding and binding by phosphorylation, peptidyl-prolyl cis/trans isomerization, and diversity of interaction partners.
1. J Chem Phys - published December 2, 2022
2. Buholzer KJ, McIvor J, Zosel F, Teppich C, Nettels D, Mercadante D, Schuler B
Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site.
1. PLoS Pathog - published December 2, 2022
2. van Vliet VJE, Huynh N, Palà J, Patel A, Singer A, Slater C, Chung J, van Huizen M, Teyra J, Miersch S, Luu GK, Ye W, Sharma N, Ganaie SS, Russell R, Chen C, Maynard M, Amarasinghe GK, Mark BL, Kikkert M, Sidhu SS
Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity.
1. Biochemistry - published December 2, 2022
2. Komaniecki G, Camarena MDC, Gelsleichter E, Mendoza R, Subler M, Windle JJ, Dozmorov MG, Lai Z, Sarkar D, Lin H
Prevention of acute GVHD disease using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T-cells in vivo.
1. Blood - published December 2, 2022
2. Lopes Ramos T, Bolivar-Wagers S, Jin S, Thangavelu G, Simonetta F, Lin PY, Hirai T, Saha A, Koehn BH, L Su L, Picton LK, Baker J, Lohmeyer JK, Riddle MJ, Eide C, Tolar J, Panoskaltsis-Mortari A, Wagner JE, Garcia KC, Negrin RS, Blazar BR
Mechanism of IFT-A polymerization into trains for ciliary transport.
1. Cell - published December 2, 2022
2. Meleppattu S, Zhou H, Dai J, Gui M, Brown A
Biologic Therapy Is Not Associated with Increased COVID-19 Severity in Patients with Hidradenitis Suppurativa: Updated Findings from the Global Hidradenitis Suppurativa COVID-19 Registry.
1. Dermatology - published December 2, 2022
2. Williams JC, Alhusayen R, Guilbault S, Hills NK, Ingram JR, Kudlinski MV, Lowes MA, Marzano AV, Paul M, Villumsen B, Yannuzzi CA, Naik HB
DNMT1 inhibition by pUG-fold quadruplex RNA.
1. RNA - published December 2, 2022
2. Jansson-Fritzberg LI, Sousa CI, Smallegan MJ, Song JJ, Gooding AR, Kasinath V, Rinn JL, Cech TR
Functionalized DNA-Origami-Protein Nanopores Generate Large Transmembrane Channels with Programmable Size-Selectivity.
1. J Am Chem Soc - published December 2, 2022
2. Shen Q, Xiong Q, Zhou K, Feng Q, Liu L, Tian T, Wu C, Xiong Y, Melia TJ, Lusk CP, Lin C
Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
1. Mol Cell - published December 2, 2022
2. Rotheneder M, Stakyte K, van de Logt E, Bartho JD, Lammens K, Fan Y, Alt A, Kessler B, Jung C, Roos WP, Steigenberger B, Hopfner KP
Oncogenic RAS promotes MYC protein stability by upregulating the expression of the inhibitor of apoptosis protein (IAP) family member Survivin.
1. J Biol Chem - published December 2, 2022
2. Chang WH, Liu Y, Hammes EA, Bryant KL, Cerione RA, Antonyak MA
Plant-specific features of respiratory supercomplex I + III(2) from Vigna radiata.
1. Nat Plants - published December 2, 2022
2. Maldonado M, Fan Z, Abe KM, Letts JA
How T118M peripheral myelin protein 22 predisposes humans to Charcot-Marie-Tooth disease.
1. J Biol Chem - published December 2, 2022
2. Stefanski KM, Li GC, Marinko JT, Carter BD, Samuels DC, Sanders CR
The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes.
1. J Biol Chem - published December 2, 2022
2. Higgins CB, Adams JA, Ward MH, Greenberg ZJ, Milewska M, Sun J, Zhang Y, Chiquetto Paracatu L, Dong Q, Ballentine S, Li W, Wandzik I, Schuettpelz LG, DeBosch BJ
Development of potent and selective degraders of PI5P4Kγ.
1. Eur J Med Chem - published December 2, 2022
2. Ji W, Wang ES, Manz TD, Jiang J, Donovan KA, Abulaiti X, Fischer ES, Cantley LC, Zhang T, Gray NS
Quality and Safety Considerations in Image Guided Radiation Therapy: An ASTRO Safety White Paper Update.
1. Pract Radiat Oncol - published December 2, 2022
2. Qi XS, Albuquerque K, Bailey S, Dawes S, Kashani R, Li H, Mak RH, Mundt AJ, Sio TT
Organelle-Selective Membrane Labeling through Phospholipase D-Mediated Transphosphatidylation.
1. JACS Au - published December 2, 2022
2. Chiu DC, Baskin JM
Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
1. Cell Rep - published December 2, 2022
2. Kouba T, Dubankova A, Drncova P, Donati E, Vidossich P, Speranzini V, Pflug A, Huchting J, Meier C, De Vivo M, Cusack S
African American Women with Cardiometabolic Complications of Pregnancy Have Decreased Serum Abundance of Specialized Pro-Resolving Lipid Mediators and Endocannabinoids.
1. Nutrients - published December 2, 2022
2. Maner-Smith KM, Ferranti E, Dunlop A, Corwin E, Ortlund EA
Snapshots of ABCG1 and ABCG5/G8: A Sterol's Journey to Cross the Cellular Membranes.
1. Int J Mol Sci - published December 2, 2022
2. Rezaei F, Farhat D, Gursu G, Samnani S, Lee JY
AP-4 loss in CRISPR-edited zebrafish affects early embryo development.
1. Adv Biol Regul - published December 2, 2022
2. Pembridge OG, Wallace NS, Clements TP, Jackson LP
Unglycosylated Soluble SARS-CoV-2 Receptor Binding Domain (RBD) Produced in E. coli Combined with the Army Liposomal Formulation Containing QS21 (ALFQ) Elicits Neutralizing Antibodies against Mismatched Variants.
1. Vaccines (Basel) - published December 2, 2022
2. Balasubramaniyam A, Ryan E, Brown D, Hamza T, Harrison W, Gan M, Sankhala RS, Chen WH, Martinez EJ, Jensen JL, Dussupt V, Mendez-Rivera L, Mayer S, King J, Michael NL, Regules J, Krebs S, Rao M, Matyas GR, Joyce MG, Batchelor AH, Gromowski GD, Dutta S
Analysis of Template Variations on RNA Synthesis by Respiratory Syncytial Virus Polymerase.
1. Viruses - published December 2, 2022
2. Cao D, Gooneratne I, Mera C, Vy J, Royal M, Huang B, Park Y, Manjunath A, Liang B
Filament assembly of the C. elegans lamin in the absence of helix 1A.
1. Nucleus - published December 1, 2022
2. de Leeuw R, Kronenberg-Tenga R, Eibauer M, Medalia O
Presence and function of Hbl B', the fourth protein component encoded by the hbl operon in Bacillus cereus.
1. Virulence - published December 1, 2022
2. Jessberger N, Diedrich R, Janowski R, Niessing D, Märtlbauer E
Human IgE mAbs identify major antigens of parasitic worm infection.
1. J Allergy Clin Immunol - published December 1, 2022
2. Hadadianpour A, Daniel J, Zhang J, Spiller BW, Makaraviciute A, DeWitt ÅM, Walden HS, Hamilton RG, Peebles RS Jr, Nutman TB, Smith SA
RCSB Protein Data bank: Tools for visualizing and understanding biological macromolecules in 3D.
1. Protein Sci - published December 1, 2022
2. Burley SK, Bhikadiya C, Bi C, Bittrich S, Chao H, Chen L, Craig PA, Crichlow GV, Dalenberg K, Duarte JM, Dutta S, Fayazi M, Feng Z, Flatt JW, Ganesan SJ, Ghosh S, Goodsell DS, Green RK, Guranovic V, Henry J, Hudson BP, Khokhriakov I, Lawson CL, Liang Y, Lowe R, Peisach E, Persikova I, Piehl DW, Rose Y, Sali A, Segura J, Sekharan M, Shao C, Vallat B, Voigt M, Webb B, Westbrook JD, Whetstone S, Young JY, Zalevsky A, Zardecki C
Coatomer in the universe of cellular complexity.
1. Mol Biol Cell - published December 1, 2022
2. Field MC, Rout MP
Construction and Functionalization of a Clathrin Assembly for a Targeted Protein Delivery.
1. Small - published December 1, 2022
2. Kim HS, Bae JH, Kim G, Song JJ, Kim HS
Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge one year later.
1. Sci Transl Med - published December 1, 2022
2. Milligan EC, Olstad K, Williams CA, Mallory M, Cano P, Cross KA, Munt JE, Garrido C, Lindesmith L, Watanabe J, Usachenko JL, Hopkins L, Immareddy R, Lakshmanappa YS, Elizaldi SR, Roh JW, Sammak RL, Pollard RE, Yee JL, Herbek S, Scobey T, Miehlke D, Fouda G, Ferrari G, Gao H, Shen X, Kozlowski PA, Montefiori D, Hudgens MG, Edwards DK, Carfi A, Corbett KS, Graham BS, Fox CB, Tomai M, Iyer SS, Baric R, Reader R, Dittmer DP, Van Rompay KKA, Permar SR, De Paris K
SARS-CoV-2 exposure in Norway rats (Rattus norvegicus) from New York City.
1. bioRxiv - published December 1, 2022
2. Wang Y, Lenoch J, Kohler D, DeLiberto TJ, Tang C, Li T, Tao YJ, Guan M, Compton S, Zeiss C, Hang J, Wan XF
Structure of a hydrophobic leucinostatin derivative determined by host lattice display.
1. Acta Crystallogr D Struct Biol - published December 1, 2022
2. Kiss C, Gall FM, Dreier B, Adams M, Riedl R, Plückthun A, Mittl PRE
Residual Lung Abnormalities Following COVID-19 Hospitalization: Interim Analysis of the UKILD Post-COVID Study.
1. Am J Respir Crit Care Med - published December 1, 2022
2. Stewart I, Jacob J, George PM, Molyneaux PL, Porter JC, Allen RJ, Aslani S, Baillie JK, Barratt SL, Beirne P, Bianchi SM, Blaikley JF, Chalmers JD, Chambers RC, Chaudhuri N, Coleman C, Collier G, Denneny EK, Docherty A, Elneima O, Evans RA, Fabbri L, Gibbons MA, Gleeson FV, Gooptu B, Greening NJ, Guillen Guio B, Hall IP, Hanley NA, Harris V, Harrison EM, Heightman M, Hillman TE, Horsley A, Houchen-Wolloff L, Jarrold I, Johnson SR, Jones MG, Khan F, Lawson R, Leavy O, Lone N, Marks M, McAuley H, Mehta P, Parekh D, Piper Hanley K, Platé M, Pearl J, Poinasamy K, Quint JK, Raman B, Richardson M, Rivera-Ortega P, Saunders L, Saunders R, Semple MG, Sereno M, Shikotra A, Simpson AJ, Singapuri A, Smith DJ, Spears M, Spencer LG, Stanel S, Thickett D, Thompson AAR, Thorpe M, Walsh SL, Walker S, Weatherley ND, Weeks M, Wild JM, Wootton DG, Brightling CE, Ho LP, Wain LV, Jenkins RG
FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales.
1. Proc Natl Acad Sci U S A - published December 1, 2022
2. Gaday Q, Megrian D, Carloni G, Martinez M, Sokolova B, Ben Assaya M, Legrand P, Brûlé S, Haouz A, Wehenkel AM, Alzari PM
Unveiling molecular insights into the mechanism of activation of oncogenic phosphoinositide 3-kinase mutants.
1. Proc Natl Acad Sci U S A - published December 1, 2022
2. Krimmer SG, Schlessinger J
Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility.
1. Nat Commun - published December 1, 2022
2. Spreacker PJ, Thomas NE, Beeninga WF, Brousseau M, Porter CJ, Hibbs KM, Henzler-Wildman KA
Pseudomonas aeruginosa aggregation and Psl expression in sputum is associated with antibiotic eradication failure in children with cystic fibrosis.
1. Sci Rep - published December 1, 2022
2. Morris AJ, Yau YCW, Park S, Eisha S, McDonald N, Parsek MR, Howell PL, Hoffman LR, Nguyen D, DiGiandomenico A, Rooney AM, Coburn B, Grana-Miraglia L, Wang P, Guttman DS, Wozniak DJ, Waters VJ
Missense VKOR mutants exhibit severe warfarin resistance but lack VKCFD via shifting to an aberrantly reduced state.
1. Blood Adv - published December 1, 2022
2. Li S, Sun J, Liu S, Zhou F, Gross M, Li W
Motivators and Barriers to COVID-19 Research Participation at the Onset of the COVID-19 Pandemic in Black Communities in the USA: an Exploratory Study.
1. J Racial Ethn Health Disparities - published December 1, 2022
2. Barre I, Cunningham-Erves J, Moss J, Parham I, Alexander LR, Davis J
Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells.
1. NPJ Breast Cancer - published December 1, 2022
2. Hancock GR, Young KS, Hosfield DJ, Joiner C, Sullivan EA, Yildiz Y, Lainé M, Greene GL, Fanning SW
Neutralization fingerprinting technology for characterizing polyclonal antibody responses to dengue vaccines.
1. Cell Rep - published December 1, 2022
2. Raju N, Zhan X, Das S, Karwal L, Dean HJ, Crowe JE Jr, Carnahan RH, Georgiev IS
Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones.
1. Nat Commun - published December 1, 2022
2. Lima NS, Musayev M, Johnston TS, Wagner DA, Henry AR, Wang L, Yang ES, Zhang Y, Birungi K, Black WP, O'Dell S, Schmidt SD, Moon D, Lorang CG, Zhao B, Chen M, Boswell KL, Roberts-Torres J, Davis RL, Peyton L, Narpala SR, O'Connell S, Serebryannyy L, Wang J, Schrager A, Talana CA, Shimberg G, Leung K, Shi W, Khashab R, Biber A, Zilberman T, Rhein J, Vetter S, Ahmed A, Novik L, Widge A, Gordon I, Guech M, Teng IT, Phung E, Ruckwardt TJ, Pegu A, Misasi J, Doria-Rose NA, Gaudinski M, Koup RA, Kwong PD, McDermott AB, Amit S, Schacker TW, Levy I, Mascola JR, Sullivan NJ, Schramm CA, Douek DC
Structural insights into the mechanism of the sodium/iodide symporter.
1. Nature - published December 1, 2022
2. Ravera S, Nicola JP, Salazar-De Simone G, Sigworth FJ, Karakas E, Amzel LM, Bianchet MA, Carrasco N
Synthetic cytokine circuits that drive T cells into immune-excluded tumors.
1. Science - published December 1, 2022
2. Allen GM, Frankel NW, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA
Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay.
1. Int J Biol Macromol - published December 1, 2022
2. Xiang Y, Zhai G, Li Y, Wang M, Chen X, Wang R, Xie H, Zhang W, Ge G, Zhang Q, Xu Y, Caflisch A, Xu J, Chen H, Chen L
Achieving single nucleotide sensitivity in direct hybridization genome imaging.
1. Nat Commun - published December 1, 2022
2. Wang Y, Cottle WT, Wang H, Gavrilov M, Zou RS, Pham MT, Yegnasubramanian S, Bailey S, Ha T
Structure of a volume-regulated heteromeric LRRC8A/C channel.
1. Nat Struct Mol Biol - published December 1, 2022
2. Rutz S, Deneka D, Dittmann A, Sawicka M, Dutzler R
Structural insights into p300 regulation and acetylation-dependent genome organisation.
1. Nat Commun - published December 1, 2022
2. Ibrahim Z, Wang T, Destaing O, Salvi N, Hoghoughi N, Chabert C, Rusu A, Gao J, Feletto L, Reynoird N, Schalch T, Zhao Y, Blackledge M, Khochbin S, Panne D
Protein import into peroxisomes occurs through a nuclear pore-like phase.
1. Science - published December 1, 2022
2. Gao Y, Skowyra ML, Feng P, Rapoport TA
Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.
1. Circulation - published December 1, 2022
2. Bersell KR, Yang T, Mosley JD, Glazer AM, Hale AT, Kryshtal DO, Kim K, Steimle JD, Brown JD, Salem JE, Campbell CC, Hong CC, Wells QS, Johnson AN, Short L, Blair MA, Behr ER, Petropoulou E, Jamshidi Y, Benson MD, Keyes MJ, Ngo D, Vasan RS, Yang Q, Gerszten RE, Shaffer C, Parikh S, Sheng Q, Kannankeril PJ, Moskowitz IP, York JD, Wang TJ, Knollmann BC, Roden DM
Mechanisms of ion selectivity and throughput in the mitochondrial calcium uniporter.
1. Sci Adv - published December 1, 2022
2. Delgado BD, Long SB
Inhibition of Fosfomycin Resistance Protein FosB from Gram-Positive Pathogens by Phosphonoformate.
1. Biochemistry - published December 1, 2022
2. Travis S, Green KD, Gilbert NC, Tsodikov OV, Garneau-Tsodikova S, Thompson MK
Charge neutralization of the active site glutamates does not limit substrate binding and transport by small multidrug resistance transporter EmrE.
1. J Biol Chem - published December 1, 2022
2. Spreacker PJ, Brousseau M, Hisao GS, Soltani M, Davis JH Jr, Henzler-Wildman KA
Data on structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8.
1. Data Brief - published December 1, 2022
2. Farhat D, Rezaei F, Lee JY
The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding.
1. PLoS Biol - published December 1, 2022
2. Bennett JA, Steward LR, Rudolph J, Voss AP, Aydin H
Bifunctional Epimerase/Reductase Enzymes Facilitate the Modulation of 6-Deoxy-Heptoses Found in the Capsular Polysaccharides of Campylobacter jejuni.
1. Biochemistry - published December 1, 2022
2. Xiang DF, Ghosh MK, Riegert AS, Thoden JB, Holden HM, Raushel FM
Polymer Modification of SARS-CoV-2 Spike Protein Impacts its Ability to Bind Key Receptor.
1. Eur Polym J - published December 1, 2022
2. Sharfin Rahman M, De Alwis Watuthanthrige N, Chandrarathne BM, Page RC, Konkolewicz D
A single 2'-O-methylation of ribosomal RNA gates assembly of a functional ribosome.
1. Nat Struct Mol Biol - published December 1, 2022
2. Yelland JN, Bravo JPK, Black JJ, Taylor DW, Johnson AW
Structural Insights into the Advances and Mechanistic Understanding of Human Dicer.
1. Biochemistry - published December 1, 2022
2. Torrez RM, Ohi MD, Garner AL
Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model.
1. Bioorg Med Chem Lett - published December 1, 2022
2. Vandeveer G, Arduini RM, Baker DP, Barry K, Bohnert T, Bowden-Verhoek JK, Conlon P, Cullen PF, Guan B, Jenkins TJ, Liao A, Lin L, Liu YT, Marcotte D, Mertsching E, Metrick CM, Negrou E, Powell N, Scott D, Silvian LF, Hopkins BT
Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.
1. Bioorg Med Chem - published December 1, 2022
2. Orsi DL, Ferrara SJ, Siegel S, Friberg A, Bouché L, Pook E, Lienau P, Bluck JP, Lemke CT, Akcay G, Stellfeld T, Meyer H, Pütter V, Holton SJ, Korr D, Jerchel-Furau I, Pantelidou C, Strathdee CA, Meyerson M, Eis K, Goldstein JT
Research Infrastructure Core Facilities at Research Centers in Minority Institutions: Part I-Research Resources Management, Operation, and Best Practices.
1. Int J Environ Res Public Health - published December 1, 2022
2. Tchounwou PB, Malouhi M, Ofili EO, Fernández-Repollet E, Sarpong DF, Yanagihara R, Aguilera RJ, Ayón C, Chen X, Dasmahapatra A, Gao S, Hinton CV, Holt R, Kolesnichenko V, Powell MD, Merchant F, Redda KK, Roche-Lima A, Shikuma CM, Stevens JJ, Torres JA, Trotter RT, Wachira J, Wang P, Wells KJ, White J, Wu Y
Micronutrient Biosynthesis Potential of Spontaneous Grain Fermentation Microbiomes.
1. Int J Environ Res Public Health - published December 1, 2022
2. Dania MI, Faraji B, Wachira J
Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists.
1. Int J Mol Sci - published December 1, 2022
2. Curreli F, Kwon YD, Nicolau I, Burgos G, Altieri A, Kurkin AV, Verardi R, Kwong PD, Debnath AK
Continuous germinal center invasion contributes to the diversity of the immune response.
1. Cell - published December 1, 2022
2. Hägglöf T, Cipolla M, Loewe M, Chen ST, Mesin L, Hartweger H, ElTanbouly MA, Cho A, Gazumyan A, Ramos V, Stamatatos L, Oliveira TY, Nussenzweig MC, Viant C
Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM.
1. Structure - published December 1, 2022
2. Amann SJ, Keihsler D, Bodrug T, Brown NG, Haselbach D
Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.
1. Structure - published December 1, 2022
2. Dazzoni R, Li Y, López-Castilla A, Brier S, Mechaly A, Cordier F, Haouz A, Nilges M, Francetic O, Bardiaux B, Izadi-Pruneyre N
Identification of new inhibitors of NS5 from dengue virus using saturation transfer difference (STD-NMR) and molecular docking studies.
1. RSC Adv - published December 1, 2022
2. Ullah A, Atia-Tul-Wahab, Gong P, Khan AM, Choudhary MI