Member Publications

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151 Member Publications for March 2022

Exploring the Role of Transglutaminase in Patients with Glioblastoma: Current Perspectives.
1. Onco Targets Ther - published March 28, 2022
2. Katt WP, Aplin C, Cerione RA
Membrane transport of cobalamin.
1. Vitam Horm - published March 26, 2022
2. Nijland M, Martínez Felices JM, Slotboom DJ, Thangaratnarajah C
Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy.
1. Front Cell Neurosci - published March 23, 2022
2. Silva MC, Nandi G, Donovan KA, Cai Q, Berry BC, Nowak RP, Fischer ES, Gray NS, Ferguson FM, Haggarty SJ
The Collagen Receptor Discoidin Domain Receptor 1b Enhances Integrin β1-Mediated Cell Migration by Interacting With Talin and Promoting Rac1 Activation.
1. Front Cell Dev Biol - published March 21, 2022
2. Borza CM, Bolas G, Zhang X, Browning Monroe MB, Zhang MZ, Meiler J, Skwark MJ, Harris RC, Lapierre LA, Goldenring JR, Hook M, Rivera J, Brown KL, Leitinger B, Tyska MJ, Moser M, Böttcher RT, Zent R, Pozzi A
The Structure of the Arabidopsis PEX4-PEX22 Peroxin Complex-Insights Into Ubiquitination at the Peroxisomal Membrane.
1. Front Cell Dev Biol - published March 18, 2022
2. Traver MS, Bradford SE, Olmos JL Jr, Wright ZJ, Miller MD, Xu W, Phillips GN Jr, Bartel B
Structural basis for activation and gating of IP(3) receptors.
1. Nat Commun - published March 17, 2022
2. Schmitz EA, Takahashi H, Karakas E
The Influence of Employee Emotion Fluctuation on Service Performance: An Experience Sampling Data Analysis.
1. Front Psychol - published March 10, 2022
2. Zhang B, Zhao L, Liu X, Bu Y, Ren Y
Introduction to the BioChemical Library (BCL): An Application-Based Open-Source Toolkit for Integrated Cheminformatics and Machine Learning in Computer-Aided Drug Discovery.
1. Front Pharmacol - published March 10, 2022
2. Brown BP, Vu O, Geanes AR, Kothiwale S, Butkiewicz M, Lowe EW Jr, Mueller R, Pape R, Mendenhall J, Meiler J
Virus-Like Particles Containing the E2 Core Domain of Hepatitis C Virus Generate Broadly Neutralizing Antibodies in Guinea Pigs.
1. J Virol - published March 9, 2022
2. McGregor J, Hardy JM, Lay CS, Boo I, Piontek M, Suckow M, Coulibaly F, Poumbourios P, Center RJ, Drummer HE
Selective pressure of endocrine therapy activates the integrated stress response through NFκB signaling in a subpopulation of ER positive breast cancer cells.
1. Breast Cancer Res - published March 9, 2022
2. Semina SE, Pal P, Kansara NS, Huggins RJ, Alarid ET, Greene GL, Frasor J
Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks.
1. Structure - published March 9, 2022
2. Huang QJ, Song K, Xu C, Bolon DNA, Wang JP, Finberg RW, Schiffer CA, Somasundaran M
The C-terminal actin-binding domain of talin forms an asymmetric catch bond with F-actin.
1. Proc Natl Acad Sci U S A - published March 8, 2022
2. Owen LM, Bax NA, Weis WI, Dunn AR
Ca²⁺-inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM.
1. Elife - published March 8, 2022
2. Nayak AR, Samsó M
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex.
1. Nat Struct Mol Biol - published March 8, 2022
2. Chen J, Wang Q, Malone B, Llewellyn E, Pechersky Y, Maruthi K, Eng ET, Perry JK, Campbell EA, Shaw DE, Darst SA
Click chemistry and optogenetic approaches to visualize and manipulate phosphatidic acid signaling.
1. J Biol Chem - published March 8, 2022
2. Tei R, Baskin JM
Fragment-Based Drug Discovery by NMR. Where Are the Successes and Where can It Be Improved?
1. Front Mol Biosci - published March 7, 2022
2. Mureddu LG, Vuister GW
How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition.
1. Elife - published March 7, 2022
2. Goodman KM, Katsamba PS, Rubinstein R, Ahlsén G, Bahna F, Mannepalli S, Dan H, Sampogna RV, Shapiro L, Honig B
Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
1. EMBO Rep - published March 7, 2022
2. Walter JD, Scherer M, Hutter CAJ, Garaeva AA, Zimmermann I, Wyss M, Rheinberger J, Ruedin Y, Earp JC, Egloff P, Sorgenfrei M, Hürlimann LM, Gonda I, Meier G, Remm S, Thavarasah S, van Geest G, Bruggmann R, Zimmer G, Slotboom DJ, Paulino C, Plattet P, Seeger MA
A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies.
1. Front Mol Biosci - published March 7, 2022
2. Skeens E, Pantouris G, Shah D, Manjula R, Ombrello MJ, Maluf NK, Bhandari V, Lisi GP, Lolis EJ
StrainGE: a toolkit to track and characterize low-abundance strains in complex microbial communities.
1. Genome Biol - published March 7, 2022
2. van Dijk LR, Walker BJ, Straub TJ, Worby CJ, Grote A, Schreiber HL 4th, Anyansi C, Pickering AJ, Hultgren SJ, Manson AL, Abeel T, Earl AM
Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer.
1. Nat Commun - published March 7, 2022
2. Lopez A, Reyna DE, Gitego N, Kopp F, Zhou H, Miranda-Roman MA, Nordstrøm LU, Narayanagari SR, Chi P, Vilar E, Tsirigos A, Gavathiotis E
Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability.
1. Microb Cell - published March 7, 2022
2. Berroyer A, Bacolla A, Tainer JA, Kim N
Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting.
1. Cell Rep - published March 7, 2022
2. Hauser BM, Sangesland M, St Denis KJ, Lam EC, Case JB, Windsor IW, Feldman J, Caradonna TM, Kannegieter T, Diamond MS, Balazs AB, Lingwood D, Schmidt AG
African American Views of COVID-19 Contact Tracing and Testing.
1. Am J Infect Control - published March 6, 2022
2. Kas-Osoka C, Moss J, Alexander L, Davis J, Parham I, Barre I, Cunningham-Erves J
Disruption of Claudin-Made Tight Junction Barriers by Clostridium perfringens Enterotoxin: Insights from Structural Biology.
1. Cells - published March 5, 2022
2. Ogbu CP, Roy S, Vecchio AJ
Isolation and Crystallization of the D156C Form of Optogenetic ChR2.
1. Cells - published March 5, 2022
2. Zhang L, Wang K, Ning S, Pedersen PA, Duelli AS, Gourdon PE
Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification.
1. Sci Adv - published March 4, 2022
2. Bärland N, Rueff AS, Cebrero G, Hutter CAJ, Seeger MA, Veening JW, Perez C
Structure of the Wilson disease copper transporter ATP7B.
1. Sci Adv - published March 4, 2022
2. Bitter RM, Oh S, Deng Z, Rahman S, Hite RK, Yuan P
Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C.
1. Nat Commun - published March 4, 2022
2. Paluda A, Middleton AJ, Rossig C, Mace PD, Day CL
Structures of RGL1 RAS-Association domain in complex with KRAS and the oncogenic G12V mutant.
1. J Mol Biol - published March 4, 2022
2. Eves BJ, Gebregiworgis T, Gasmi-Seabrook GMC, Kuntz DA, Privé GG, Marshall CB, Ikura M
Small integral membrane protein 10 like 1 enhances differentiation of adipose progenitor cells.
1. Biochem Biophys Res Commun - published March 4, 2022
2. Nebe M, Kehr S, Schmitz S, Breitfeld J, Lorenz J, Le Duc D, Stadler PF, Meiler J, Kiess W, Garten A, Kirstein AS
Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase.
1. Front Mol Biosci - published March 3, 2022
2. Frey KM, Bertoletti N, Chan AH, Ippolito JA, Bollini M, Spasov KA, Jorgensen WL, Anderson KS
Discovery and Optimization of 6-(1-Substituted pyrrole-2-yl)-s-triazine Containing Compounds as Antibacterial Agents.
1. ACS Infect Dis - published March 3, 2022
2. Green KD, Pang AH, Thamban Chandrika N, Garzan A, Baughn AD, Tsodikov OV, Garneau-Tsodikova S
Sampling alternative conformational states of transporters and receptors with AlphaFold2.
1. Elife - published March 3, 2022
2. Del Alamo D, Sala D, Mchaourab HS, Meiler J
Efficient discovery of SARS-CoV-2-neutralizing antibodies via B cell receptor sequencing and ligand blocking.
1. Nat Biotechnol - published March 3, 2022
2. Shiakolas AR, Kramer KJ, Johnson NV, Wall SC, Suryadevara N, Wrapp D, Periasamy S, Pilewski KA, Raju N, Nargi R, Sutton RE, Walker LM, Setliff I, Crowe JE Jr, Bukreyev A, Carnahan RH, McLellan JS, Georgiev IS
The oxytocin signaling complex reveals a molecular switch for cation dependence.
1. Nat Struct Mol Biol - published March 3, 2022
2. Meyerowitz JG, Robertson MJ, Barros-Álvarez X, Panova O, Nwokonko RM, Gao Y, Skiniotis G
Development of an atmospheric plasma jet device for versatile treatment of electron microscope sample grids.
1. J Biol Chem - published March 3, 2022
2. Ahn E, Tang T, Kim B, Lee HJ, Cho US
The In Vivo and In Vitro Architecture of the Hepatitis C Virus RNA Genome Uncovers Functional RNA Secondary and Tertiary Structures.
1. J Virol - published March 3, 2022
2. Wan H, Adams RL, Lindenbach BD, Pyle AM
Rixosomal RNA degradation contributes to silencing of Polycomb target genes.
1. Nature - published March 3, 2022
2. Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, Zhang J, Luo Z, Gygi SP, Adelman K, Moazed D
Structures of Tetrahymena's respiratory chain reveal the diversity of eukaryotic core metabolism.
1. Science - published March 3, 2022
2. Zhou L, Maldonado M, Padavannil A, Guo F, Letts JA
NMR-derived secondary structure of the full-length Ox40 mRNA 3'UTR and its multivalent binding to the immunoregulatory RBP Roquin.
1. Nucleic Acids Res - published March 3, 2022
2. Tants JN, Becker LM, McNicoll F, Müller-McNicoll M, Schlundt A
Assembly mechanism of the pleomorphic immature poxvirus scaffold.
1. Nat Commun - published March 3, 2022
2. Hyun J, Matsunami H, Kim TG, Wolf M
Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine.
1. Cell Chem Biol - published March 3, 2022
2. Hulce KR, Jaishankar P, Lee GM, Bohn MF, Connelly EJ, Wucherer K, Ongpipattanakul C, Volk RF, Chuo SW, Arkin MR, Renslo AR, Craik CS
Proteomic elucidation of the targets and primary functions of the picornavirus 2A protease.
1. J Biol Chem - published March 3, 2022
2. Serganov AA, Udi Y, Stein ME, Patel V, Fridy PC, Rice CM, Saeed M, Jacobs EY, Chait BT, Rout MP
Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site.
1. Structure - published March 3, 2022
2. Zhou T, Chen L, Gorman J, Wang S, Kwon YD, Lin BC, Louder MK, Rawi R, Stancofski ED, Yang Y, Zhang B, Quigley AF, McCoy LE, Rutten L, Verrips T, Weiss RA, VRC Production Program., Doria-Rose NA, Shapiro L, Kwong PD
Structural Insight into KsBcl-2 Mediated Apoptosis Inhibition by Kaposi Sarcoma Associated Herpes Virus.
1. Viruses - published March 3, 2022
2. Suraweera CD, Hinds MG, Kvansakul M
A Structural Perspective on Calprotectin as a Ligand of Receptors Mediating Inflammation and Potential Drug Target.
1. Biomolecules - published March 3, 2022
2. Garcia V, Perera YR, Chazin WJ
Secondary structural ensembles of the SARS-CoV-2 RNA genome in infected cells.
1. Nat Commun - published March 2, 2022
2. Lan TCT, Allan MF, Malsick LE, Woo JZ, Zhu C, Zhang F, Khandwala S, Nyeo SSY, Sun Y, Guo JU, Bathe M, Näär A, Griffiths A, Rouskin S
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes.
1. Nat Struct Mol Biol - published March 2, 2022
2. Costello SM, Shoemaker SR, Hobbs HT, Nguyen AW, Hsieh CL, Maynard JA, McLellan JS, Pak JE, Marqusee S
Verteporfin is a Substrate-Selective γ-Secretase Inhibitor that Binds the Amyloid Precursor Protein Transmembrane Domain.
1. J Biol Chem - published March 2, 2022
2. Castro MA, Parson KF, Beg I, Wilkinson MC, Nurmakova K, Levesque I, Voehler MW, Wolfe MS, Ruotolo BT, Sanders CR
Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors.
1. Cell - published March 2, 2022
2. Xiong X, Tian S, Yang P, Lebreton F, Bao H, Sheng K, Yin L, Chen P, Zhang J, Qi W, Ruan J, Wu H, Chen H, Breault DT, Wu H, Earl AM, Gilmore MS, Abraham J, Dong M
The Molecular Basis of FIX Deficiency in Hemophilia B.
1. Int J Mol Sci - published March 2, 2022
2. Shen G, Gao M, Cao Q, Li W
Correlation between structure and function in phosphatidylinositol lipid-dependent Kir2.2 gating.
1. Proc Natl Acad Sci U S A - published March 2, 2022
2. Zhang Y, Tao X, MacKinnon R
Interleukin-2 superkines by computational design.
1. Proc Natl Acad Sci U S A - published March 2, 2022
2. Ren J, Chu AE, Jude KM, Picton LK, Kare AJ, Su L, Montano Romero A, Huang PS, Garcia KC
Influence of Oxidation On Structure, Performance, and Application of Metallic Glasses.
1. Adv Mater - published March 2, 2022
2. Zhang M, Huang T, Zhang J, Deng L, Gong P, Wang X
Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases.
1. mBio - published March 2, 2022
2. Bradley NP, Wahl KL, Steenwyk JL, Rokas A, Eichman BF
Phosphorylation of SHP2 at Tyr62 enables acquired resistance to SHP2 allosteric inhibitors in FLT3-ITD-driven AML.
1. Cancer Res - published March 2, 2022
2. Pfeiffer A, Franciosa G, Locard-Paulet M, Piga I, Reckzeh K, Vemulapalli V, Blacklow SC, Theilgaard-Mönch K, Jensen LJ, Olsen JV
Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins.
1. Elife - published March 2, 2022
2. Lambey P, Otun O, Cong X, Hoh F, Brunel L, Verdié P, Grison CM, Peysson F, Jeannot S, Durroux T, Bechara C, Granier S, Leyrat C
Ligand binding remodels protein side chain conformational heterogeneity.
1. Elife - published March 2, 2022
2. Wankowicz SA, de Oliveira SH, Hogan DW, van den Bedem H, Fraser JS
Eicosanoid signaling blockade protects middle-aged mice from severe COVID-19.
1. Nature - published March 2, 2022
2. Wong LR, Zheng J, Wilhelmsen K, Li K, Ortiz ME, Schnicker NJ, Thurman A, Pezzulo AA, Szachowicz PJ, Li P, Pan R, Klumpp K, Aswad F, Rebo J, Narumiya S, Murakami M, Zuniga S, Sola I, Enjuanes L, Meyerholz DK, Fortney K, McCray PB Jr, Perlman S
Hitting the hotspots.
1. Nat Chem Biol - published March 2, 2022
2. Marshall CB, Ikura M
Confirmation of association of TGFBI p.Ser591Phe mutation with variant lattice corneal dystrophy.
1. Ophthalmic Genet - published March 2, 2022
2. Choo CH, Chung DD, Ledwitch KV, Kassels A, Meiler J, Aldave AJ
Mechanisms of loading and release of the 9-1-1 checkpoint clamp.
1. Nat Struct Mol Biol - published March 2, 2022
2. Castaneda JC, Schrecker M, Remus D, Hite RK
Time to complete hepatitis C cascade of care among patients identified during mass screening campaigns in rural Rwanda: a retrospective cohort study.
1. BMC Infect Dis - published March 2, 2022
2. Kamali I, Shumbusho F, Barnhart DA, Nyirahabihirwe F, Gakuru JP, Dusingizimana W, Nizeyumuremyi E, Habinshuti P, Walker S, Makuza JD, Serumondo J, Nshogoza Rwibasira G, Ndahimana JD
Identification of natural compounds tubercidin and lycorine HCl against small-cell lung cancer and BCAT1 as a therapeutic target.
1. J Cell Mol Med - published March 2, 2022
2. Chen J, Barrett L, Lin Z, Kendrick S, Mu S, Dai L, Qin Z
Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2.
1. Adv Sci (Weinh) - published March 2, 2022
2. Gao N, Gai Y, Meng L, Wang C, Wang W, Li X, Gu T, Louder MK, Doria-Rose NA, Wiehe K, Nazzari AF, Olia AS, Gorman J, Rawi R, Wu W, Smith C, Khant H, de Val N, Yu B, Luo J, Niu H, Tsybovsky Y, Liao H, Kepler TB, Kwong PD, Mascola JR, Qin C, Zhou T, Yu X, Gao F
Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike.
1. Elife - published March 2, 2022
2. Diaz-Salinas MA, Li Q, Ejemel M, Yurkovetskiy L, Luban J, Shen K, Wang Y, Munro JB
Publisher Correction: ER proteins decipher the tubulin code to regulate organelle distribution.
1. Nature - published March 2, 2022
2. Zheng P, Obara CJ, Szczesna E, Nixon-Abell J, Mahalingan KK, Roll-Mecak A, Lippincott-Schwartz J, Blackstone C
Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides.
1. Nature - published March 2, 2022
2. Lai Y, Fois G, Flores JR, Tuvim MJ, Zhou Q, Yang K, Leitz J, Peters J, Zhang Y, Pfuetzner RA, Esquivies L, Jones P, Frick M, Dickey BF, Brunger AT
Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529.
1. Science - published March 2, 2022
2. Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Glutathione binding to the plant AtAtm3 transporter and implications for the conformational coupling of ABC transporters.
1. Elife - published March 2, 2022
2. Fan C, Rees DC
Bound nucleotide can control the dynamic architecture of monomeric actin.
1. Nat Struct Mol Biol - published March 2, 2022
2. Ali R, Zahm JA, Rosen MK
pH regulates potassium conductance and drives a constitutive proton current in human TMEM175.
1. Sci Adv - published March 2, 2022
2. Zheng W, Shen C, Wang L, Rawson S, Xie WJ, Nist-Lund C, Wu J, Shen Z, Xia S, Holt JR, Wu H, Fu TM
New COL6A6 Variant Causes Autosomal Dominant Retinitis Pigmentosa in a Four-Generation Family.
1. Invest Ophthalmol Vis Sci - published March 2, 2022
2. Vaclavik V, Tiab L, Sun YJ, Mahajan VB, Moulin A, Allaman-Pillet N, Munier FL, Schorderet DF
Design of protein binding proteins from target structure alone.
1. Nature - published March 2, 2022
2. Cao L, Coventry B, Goreshnik I, Huang B, Park JS, Jude KM, Marković I, Kadam RU, Verschueren KHG, Verstraete K, Walsh STR, Bennett N, Phal A, Yang A, Kozodoy L, DeWitt M, Picton L, Miller L, Strauch EM, DeBouver ND, Pires A, Bera AK, Halabiya S, Hammerson B, Yang W, Bernard S, Stewart L, Wilson IA, Ruohola-Baker H, Schlessinger J, Lee S, Savvides SN, Garcia KC, Baker D
Enzymatic Analysis of WWP2 E3 Ubiquitin Ligase Using Protein Microarrays Identifies Autophagy-Related Substrates.
1. J Biol Chem - published March 2, 2022
2. Jiang H, Chiang CY, Chen Z, Nathan S, D'Agostino G, Paulo JA, Song G, Zhu H, Gabelli SB, Cole PA
Native-like environments afford novel mechanistic insights into membrane proteins.
1. Trends Biochem Sci - published March 2, 2022
2. Notti RQ, Walz T
CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.
1. Nat Commun - published March 2, 2022
2. Joung J, Kirchgatterer PC, Singh A, Cho JH, Nety SP, Larson RC, Macrae RK, Deasy R, Tseng YY, Maus MV, Zhang F
The Atypical Cobalamin-Dependent S-Adenosyl-l-Methionine Nonradical Methylase TsrM and Its Radical Counterparts.
1. J Am Chem Soc - published March 2, 2022
2. Ulrich EC, Drennan CL
Functional and Highly Cross-Linkable HIV-1 Envelope Glycoproteins Enriched in a Pretriggered Conformation.
1. J Virol - published March 2, 2022
2. Nguyen HT, Qualizza A, Anang S, Zhao M, Zou S, Zhou R, Wang Q, Zhang S, Deshpande A, Ding H, Chiu TJ, Smith AB 3rd, Kappes JC, Sodroski JG
A stereochemical journey around spirocyclic glutamic acid analogs.
1. Org Biomol Chem - published March 2, 2022
2. Chernykh AV, Chernykh AV, Radchenko DS, Chheda PR, Rusanov EB, Grygorenko OO, Spies MA, Volochnyuk DM, Komarov IV
Structural and mechanistic basis for redox sensing by the cyanobacterial transcription regulator RexT.
1. Commun Biol - published March 2, 2022
2. Li B, Jo M, Liu J, Tian J, Canfield R, Bridwell-Rabb J
PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites.
1. Nucleic Acids Res - published March 2, 2022
2. Lin X, Jiang W, Rudolph J, Lee BJ, Luger K, Zha S
Self-amplifying mRNA SARS-CoV-2 vaccines raise cross-reactive immune response to variants and prevent infection in animal models.
1. Mol Ther Methods Clin Dev - published March 2, 2022
2. Palladino G, Chang C, Lee C, Music N, De Souza I, Nolasco J, Amoah S, Suphaphiphat P, Otten GR, Settembre EC, Wen Y
A feature-guided, focused 3D signal permutation method for subtomogram averaging.
1. J Struct Biol - published March 2, 2022
2. Jacob Peters J, Leitz J, Guo Q, Beck F, Baumeister W, Brunger AT
Convergent evolution in two bacterial replicative helicase loaders.
1. Trends Biochem Sci - published March 2, 2022
2. Chase J, Berger J, Jeruzalmi D
Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs.
1. J Struct Biol - published March 2, 2022
2. Obr M, Jh Hagen W, Dick RA, Yu L, Kotecha A, Km Schur F
Improved Anti-Vulcanization and Bonding Performance of a Silver Alloy Bonding Wire by a Cathodic Passivation Treatment with Palladium.
1. Materials (Basel) - published March 2, 2022
2. Yang G, Zhou Z, Zhang H, Zhang Y, Peng Z, Gong P, Wang X, Cui C
Optical and Mechanical Properties of Self-Repairing Pectin Biopolymers.
1. Polymers (Basel) - published March 2, 2022
2. Pierce AF, Liu BS, Liao M, Wagner WL, Khalil HA, Chen Z, Ackermann M, Mentzer SJ
Metazoans and Intrinsic Apoptosis: An Evolutionary Analysis of the Bcl-2 Family.
1. Int J Mol Sci - published March 2, 2022
2. Suraweera CD, Banjara S, Hinds MG, Kvansakul M
mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron.
1. Cell - published March 2, 2022
2. Gagne M, Moliva JI, Foulds KE, Andrew SF, Flynn BJ, Werner AP, Wagner DA, Teng IT, Lin BC, Moore C, Jean-Baptiste N, Carroll R, Foster SL, Patel M, Ellis M, Edara VV, Maldonado NV, Minai M, McCormick L, Honeycutt CC, Nagata BM, Bock KW, Dulan CNM, Cordon J, Flebbe DR, Todd JM, McCarthy E, Pessaint L, Van Ry A, Narvaez B, Valentin D, Cook A, Dodson A, Steingrebe K, Nurmukhambetova ST, Godbole S, Henry AR, Laboune F, Roberts-Torres J, Lorang CG, Amin S, Trost J, Naisan M, Basappa M, Willis J, Wang L, Shi W, Doria-Rose NA, Zhang Y, Yang ES, Leung K, O'Dell S, Schmidt SD, Olia AS, Liu C, Harris DR, Chuang GY, Stewart-Jones G, Renzi I, Lai YT, Malinowski A, Wu K, Mascola JR, Carfi A, Kwong PD, Edwards DK, Lewis MG, Andersen H, Corbett KS, Nason MC, McDermott AB, Suthar MS, Moore IN, Roederer M, Sullivan NJ, Douek DC, Seder RA
Structural diversity of the SARS-CoV-2 Omicron spike.
1. Mol Cell - published March 2, 2022
2. Gobeil SM, Henderson R, Stalls V, Janowska K, Huang X, May A, Speakman M, Beaudoin E, Manne K, Li D, Parks R, Barr M, Deyton M, Martin M, Mansouri K, Edwards RJ, Eaton A, Montefiori DC, Sempowski GD, Saunders KO, Wiehe K, Williams W, Korber B, Haynes BF, Acharya P
Co-Operative Biofilm Interactions between Aspergillus fumigatus and Pseudomonas aeruginosa through Secreted Galactosaminogalactan Exopolysaccharide.
1. J Fungi (Basel) - published March 2, 2022
2. Ostapska H, Le Mauff F, Gravelat FN, Snarr BD, Bamford NC, Van Loon JC, McKay G, Nguyen D, Howell PL, Sheppard DC
Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice.
1. Cell - published March 2, 2022
2. Ying B, Scheaffer SM, Whitener B, Liang CY, Dmytrenko O, Mackin S, Wu K, Lee D, Avena LE, Chong Z, Case JB, Ma L, Kim TTM, Sein CE, Woods A, Berrueta DM, Chang GY, Stewart-Jones G, Renzi I, Lai YT, Malinowski A, Carfi A, Elbashir SM, Edwards DK, Thackray LB, Diamond MS
Electron cryo-tomography structure of axonemal doublet microtubule from Tetrahymena thermophila.
1. Life Sci Alliance - published March 1, 2022
2. Li S, Fernandez JJ, Fabritius AS, Agard DA, Winey M
Cryo-EM analysis of Ebola virus nucleocapsid-like assembly.
1. STAR Protoc - published March 1, 2022
2. Wang Y, Binning JM, Pintilie GD, Chiu W, Amarasinghe GK, Leung DW, Su Z
A protocol to inject ocular drug implants into mouse eyes.
1. STAR Protoc - published March 1, 2022
2. Lin CH, Sun YJ, Lee SH, Mujica EM, Kunchur CR, Wu MR, Yang J, Jung YS, Chiang B, Wang S, Mahajan VB
Nuclear lamins: Structure and function in mechanobiology.
1. APL Bioeng - published March 1, 2022
2. Vahabikashi A, Adam SA, Medalia O, Goldman RD
Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion.
1. Proc Natl Acad Sci U S A - published March 1, 2022
2. Vora SM, Fontana P, Mao T, Leger V, Zhang Y, Fu TM, Lieberman J, Gehrke L, Shi M, Wang L, Iwasaki A, Wu H
Molecular basis of multistep voltage activation in plant two-pore channel 1.
1. Proc Natl Acad Sci U S A - published March 1, 2022
2. Dickinson MS, Lu J, Gupta M, Marten I, Hedrich R, Stroud RM
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2.
1. Proc Natl Acad Sci U S A - published March 1, 2022
2. Singh RK, Soliman A, Guaitoli G, Störmer E, von Zweydorf F, Dal Maso T, Oun A, Van Rillaer L, Schmidt SH, Chatterjee D, David JA, Pardon E, Schwartz TU, Knapp S, Kennedy EJ, Steyaert J, Herberg FW, Kortholt A, Gloeckner CJ, Versées W
Erratum for Benler et al., "Cargo Genes of Tn7-Like Transposons Comprise an Enormous Diversity of Defense Systems, Mobile Genetic Elements, and Antibiotic Resistance Genes".
1. mBio - published March 1, 2022
2. Benler S, Faure G, Tran HA, Shmakov S, Zhang F, Koonin E
Establishing the role of the gut microbiota in susceptibility to recurrent urinary tract infections.
1. J Clin Invest - published March 1, 2022
2. Worby CJ, Olson BS, Dodson KW, Earl AM, Hultgren SJ
Programming 2D Supramolecular Assemblies with Wireframe DNA Origami.
1. J Am Chem Soc - published March 1, 2022
2. Wang X, Jun H, Bathe M
Crystal structure of a hypothetical protein from Giardia lamblia. Corrigendum.
1. Acta Crystallogr F Struct Biol Commun - published March 1, 2022
2. Beard DK, Bristol S, Cosby K, Davis A, Manning C, Perry L, Snapp L, Toy A, Wheeler K, Young J, Staker B, Arakaki TL, Abendroth J, Subramanian S, Edwards TE, Myler PJ, Asojo OA
ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis.
1. Nat Commun - published March 1, 2022
2. Ramirez NP, Lee J, Zheng Y, Li L, Dennis B, Chen D, Challa A, Planelles V, Westover KD, Alto NM, D'Orso I
Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system.
1. Open Biol - published March 1, 2022
2. Natarajan V, Simoneau CR, Erickson AL, Meyers NL, Baron JL, Cooper S, McDevitt TC, Ott M
Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx.
1. Acta Crystallogr F Struct Biol Commun - published March 1, 2022
2. Maddy J, Staker BL, Subramanian S, Abendroth J, Edwards TE, Myler PJ, Hybiske K, Asojo OA
A simple technique to classify diffraction data from dynamic proteins according to individual polymorphs.
1. Acta Crystallogr D Struct Biol - published March 1, 2022
2. Nguyen T, Phan KL, Kozakov D, Gabelli SB, Kreitler DF, Andrews LC, Jakoncic J, Sweet RM, Soares AS, Bernstein HJ
Surgical management of acanthamoeba chorioretinitis.
1. Am J Ophthalmol Case Rep - published March 1, 2022
2. Mishra K, Velez G, Roybal CN, Mahajan VB
SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo.
1. Cancer Lett - published March 1, 2022
2. Wang Y, Yang C, Sims MM, Sacher JR, Raje M, Deokar H, Yue P, Turkson J, Buolamwini JK, Pfeffer LM
Fast automated energy changes at synchrotron radiation beamlines equipped with transfocator or focusing mirrors.
1. J Synchrotron Radiat - published March 1, 2022
2. Stepanov S, Kissick D, Makarov O, Hilgart M, Becker M, Venugopalan N, Xu S, Smith JL, Fischetti RF
Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells.
1. NAR Cancer - published March 1, 2022
2. Florian AC, Woodley CM, Wang J, Grieb BC, Slota MJ, Guerrazzi K, Hsu CY, Matlock BK, Flaherty DK, Lorey SL, Fesik SW, Howard GC, Liu Q, Weissmiller AM, Tansey WP
Accurate positioning of functional residues with robotics-inspired computational protein design.
1. Proc Natl Acad Sci U S A - published March 1, 2022
2. Krivacic C, Kundert K, Pan X, Pache RA, Liu L, Conchúir SO, Jeliazkov JR, Gray JJ, Thompson MC, Fraser JS, Kortemme T
Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.
1. Proc Natl Acad Sci U S A - published March 1, 2022
2. Zhang S, Nelson OD, Price IR, Zhu C, Lu X, Fernandez IR, Weiss RS, Lin H
Inhibitors of PARP: Number crunching and structure gazing.
1. Proc Natl Acad Sci U S A - published March 1, 2022
2. Rudolph J, Jung K, Luger K
A possible role for VPS13-family proteins in bulk lipid transfer, membrane expansion and organelle biogenesis.
1. J Cell Sci - published March 1, 2022
2. Melia TJ, Reinisch KM
Small molecule modulation of protein polymerization.
1. Chem Soc Rev - published March 1, 2022
2. Fischer ES, Jones LH
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.
1. Science - published March 1, 2022
2. Glassman CR, Tsutsumi N, Saxton RA, Lupardus PJ, Jude KM, Garcia KC
Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales).
1. J Virol - published March 1, 2022
2. Kuang W, Zhang H, Cai Y, Zhang G, Deng F, Li H, Zhou Y, Wang M, Gong P, Guo Y, Hu Z
Atomic structure of the predominant GII.4 human norovirus capsid reveals novel stability and plasticity.
1. Nat Commun - published March 1, 2022
2. Hu L, Salmen W, Chen R, Zhou Y, Neill F, Crowe JE Jr, Atmar RL, Estes MK, Prasad BVV
Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies.
1. Sci Adv - published March 1, 2022
2. Wrapp D, Ye X, Ku Z, Su H, Jones HG, Wang N, Mishra AK, Freed DC, Li F, Tang A, Li L, Jaijyan DK, Zhu H, Wang D, Fu TM, Zhang N, An Z, McLellan JS
A saturation-mutagenesis analysis of the interplay between stability and activation in Ras.
1. Elife - published March 1, 2022
2. Hidalgo F, Nocka LM, Shah NH, Gorday K, Latorraca NR, Bandaru P, Templeton S, Lee D, Karandur D, Pelton JG, Marqusee S, Wemmer D, Kuriyan J
The Bacterial Cell Wall: From Lipid II Flipping to Polymerization.
1. Chem Rev - published March 1, 2022
2. Kumar S, Mollo A, Kahne D, Ruiz N
MITI minimum information guidelines for highly multiplexed tissue images.
1. Nat Methods - published March 1, 2022
2. Schapiro D, Yapp C, Sokolov A, Reynolds SM, Chen YA, Sudar D, Xie Y, Muhlich J, Arias-Camison R, Arena S, Taylor AJ, Nikolov M, Tyler M, Lin JR, Burlingame EA, Human Tumor Atlas Network., Chang YH, Farhi SL, Thorsson V, Venkatamohan N, Drewes JL, Pe'er D, Gutman DA, Herrmann MD, Gehlenborg N, Bankhead P, Roland JT, Herndon JM, Snyder MP, Angelo M, Nolan G, Swedlow JR, Schultz N, Merrick DT, Mazzili SA, Cerami E, Rodig SJ, Santagata S, Sorger PK
Incidence and prevalence of COVID-19 within a healthcare worker cohort during the first year of the SARS-CoV-2 pandemic.
1. Clin Infect Dis - published March 1, 2022
2. Doernberg SB, Holubar M, Jain V, Weng Y, Lu D, Bollyky JB, Sample H, Huang B, Craik CS, Desai M, Rutherford GW, Maldonado Y, CHART Study Consortium.
Simultaneous strength and ductility enhancements of high thermal conductive Ag7.5Cu alloy by selective laser melting.
1. Sci Rep - published March 1, 2022
2. Xiong W, Hao L, Peijs T, Yan C, Cheng K, Gong P, Cui Q, Tang D, Al Islam S, Li Y
Structure and Function of an N-acetyltransferase from the Human Pathogen Acinetobacter baumannii Isolate BAL_212.
1. Proteins - published March 1, 2022
2. Herkert NR, Thoden JB, Holden HM
Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2.
1. J Biol Chem - published March 1, 2022
2. Cale EM, Driscoll JI, Lee M, Gorman J, Zhou T, Lu M, Geng H, Lai YT, Chuang GY, Doria-Rose NA, Mothes W, Kwong PD, Mascola JR
Advances in Mass Spectrometry-Based Footprinting of Membrane Proteins.
1. Proteomics - published March 1, 2022
2. Sun J, Li W, Gross ML
Developing a COVID-19 WHO Clinical Progression Scale Inpatient Database from Electronic Health Record Data.
1. J Am Med Inform Assoc - published March 1, 2022
2. Ramaswamy P, Gong JJ, Saleh SN, McDonald SA, Blumberg S, Medford RJ, Liu X
Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins.
1. Nat Commun - published March 1, 2022
2. Hsieh CL, Rush SA, Palomo C, Chou CW, Pickens W, Más V, McLellan JS
Omicron variant Spike-specific antibody binding and Fc activity is preserved in recipients of mRNA or inactivated COVID-19 vaccines.
1. Sci Transl Med - published March 1, 2022
2. Bartsch YC, Tong X, Kang J, Avendaño MJ, Serrano EF, García-Salum T, Pardo-Roa C, Riquelme A, Cai Y, Renzi I, Stewart-Jones G, Chen B, Medina RA, Alter G
Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape.
1. mBio - published March 1, 2022
2. Rochman ND, Faure G, Wolf YI, Freddolino PL, Zhang F, Koonin EV
Global Increases in Human Immunodeficiency Virus Neutralization Sensitivity Due to Alterations in the Membrane-Proximal External Region of the Envelope Glycoprotein Can Be Minimized by Distant State 1-Stabilizing Changes.
1. J Virol - published March 1, 2022
2. Wang Q, Esnault F, Zhao M, Chiu TJ, Smith AB 3rd, Nguyen HT, Sodroski JG
Computational Cosolvent Mapping Analysis Leads to Identify Salicylic Acid Analogs as Weak Inhibitors of ST2 and IL33 Binding.
1. J Phys Chem B - published March 1, 2022
2. Yuan X, Chinnaswamy K, Stuckey JA, Yang CY
Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A.
1. J Med Chem - published March 1, 2022
2. Hawkins PME, Hoi DM, Cheung CY, Wang T, Quan D, Sasi VM, Liu DY, Linington RG, Jackson CJ, Oehlers SH, Cook GM, Britton WJ, Clausen T, Payne RJ
Temporal and spatial topography of cell proliferation in cancer.
1. Nat Cell Biol - published March 1, 2022
2. Gaglia G, Kabraji S, Rammos D, Dai Y, Verma A, Wang S, Mills CE, Chung M, Bergholz JS, Coy S, Lin JR, Jeselsohn R, Metzger O, Winer EP, Dillon DA, Zhao JJ, Sorger PK, Santagata S
Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells.
1. J Med Chem - published March 1, 2022
2. Smalley JP, Baker IM, Pytel WA, Lin LY, Bowman KJ, Schwabe JWR, Cowley SM, Hodgkinson JT
Single cell transcriptome profile of mouse skin undergoing antigen driven allergic inflammation recapitulates findings in atopic dermatitis skin lesions.
1. J Allergy Clin Immunol - published March 1, 2022
2. Leyva-Castillo JM, Sun L, Wu SY, Rockowitz S, Sliz P, Geha R
Structural mechanism of muscle nicotinic receptor desensitization and block by curare.
1. Nat Struct Mol Biol - published March 1, 2022
2. Rahman MM, Basta T, Teng J, Lee M, Worrell BT, Stowell MHB, Hibbs RE
Andrographolide Attenuates Blood-Brain Barrier Disruption, Neuronal Apoptosis, and Oxidative Stress Through Activation of Nrf2/HO-1 Signaling Pathway in Subarachnoid Hemorrhage.
1. Neurotox Res - published March 1, 2022
2. Gong P, Zhang W, Zou C, Han S, Tian Q, Wang J, He P, Guo Y, Li M
Silybins inhibit human IAPP amyloid growth and toxicity through stereospecific interactions.
1. Biochim Biophys Acta Proteins Proteom - published March 1, 2022
2. García-Viñuales S, Ilie IM, Santoro AM, Romanucci V, Zarrelli A, Di Fabio G, Caflisch A, Milardi D
Special issue entitled Lipid transporters edited by Shamshad Cockcroft and Padinjat Raghu.
1. Biochim Biophys Acta Mol Cell Biol Lipids - published March 1, 2022
2. Dickson EJ, Leonzino M, Reinisch KM, De Camilli P, Noda NN, Schoop V, Martello A, Eden ER, Hoglinger D, Naito T, Saheki Y, Raghu P, Basak B, Krishnan H, Ashlin TG, Blunsom NJ, Cockcroft S, Holic R, Stastny D, Griac P, Backman APE, Mattjus P, Ressurreicao M, van Ooij C, Jamecna D, Antonny B
Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate.
1. J Biol Chem - published March 1, 2022
2. Sanchez AM, Jacewicz A, Shuman S
Facile discovery of surrogate cytokine agonists.
1. Cell - published March 1, 2022
2. Yen M, Ren J, Liu Q, Glassman CR, Sheahan TP, Picton LK, Moreira FR, Rustagi A, Jude KM, Zhao X, Blish CA, Baric RS, Su LL, Garcia KC
Oxygen-Sensitive Metalloprotein Structure Determination by Cryo-Electron Microscopy.
1. Biomolecules - published March 1, 2022
2. Cherrier MV, Vernède X, Fenel D, Martin L, Arragain B, Neumann E, Fontecilla-Camps JC, Schoehn G, Nicolet Y
Exploiting Radiation Induction of Antigens in Cancer: Targeted Drug Delivery.
1. Int J Mol Sci - published March 1, 2022
2. Kapoor V, Singh AK, Lewis CD, Deore S, Hallahan DE
Structural Comparative Modeling of Multi-Domain F508del CFTR.
1. Biomolecules - published March 1, 2022
2. McDonald EF, Woods H, Smith ST, Kim M, Schoeder CT, Plate L, Meiler J
Structural Basis of the Avian Influenza NS1 Protein Interactions with the Cell Polarity Regulator Scribble.
1. Viruses - published March 1, 2022
2. Javorsky A, Humbert PO, Kvansakul M
Harnessing coronavirus spike proteins' binding affinity to ACE2 receptor through a novel baculovirus surface display system.
1. Biochem Biophys Res Commun - published March 1, 2022
2. Wang L, Zhao L, Li Y, Ma P, Kornberg RD, Nie Y