Member Publications

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129 Member Publications for October 2021

Challenges in Detection of Serum Oncoprotein: Relevance to Breast Cancer Diagnostics.
1. Breast Cancer (Dove Med Press) - published October 27, 2021
2. Lengfeld J, Zhang H, Stoesz S, Murali R, Pass F, Greene MI, Goel PN, Grover P
Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization.
1. Front Immunol - published October 25, 2021
2. Thornlow DN, Macintyre AN, Oguin TH, Karlsson AB, Stover EL, Lynch HE, Sempowski GD, Schmidt AG
Sirtuin Modulators in Cellular and Animal Models of Human Diseases.
1. Front Pharmacol - published October 15, 2021
2. Hong JY, Lin H
Indirubin Derivatives as Dual Inhibitors Targeting Cyclin-Dependent Kinase and Histone Deacetylase for Treating Cancer.
1. J Med Chem - published October 8, 2021
2. Cao Z, Yang F, Wang J, Gu Z, Lin S, Wang P, An J, Liu T, Li Y, Li Y, Lin H, Zhao Y, He B
Use of Community Listening Sessions to Disseminate Research Findings to Past Participants and Communities.
1. J Community Health - published October 8, 2021
2. Cunningham-Erves J, Stewart EC, Duke J, Alexander L, Davis J, Wilus D, Wyche-Etheridge K, Miller ST
Sulfation of glycosaminoglycans depends on catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro.
1. J Biol Chem - published October 8, 2021
2. Eisele BS, Luka Z, Wu AJ, Yang F, Hale AT, York JD
Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex.
1. Cell Rep - published October 8, 2021
2. Wu J, Wang H, Liu Q, Li R, Gao Y, Fang X, Zhong Y, Wang M, Wang Q, Rao Z, Gong P
Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD.
1. Cell Rep - published October 8, 2021
2. Errico JM, Zhao H, Chen RE, Liu Z, Case JB, Ma M, Schmitz AJ, Rau MJ, Fitzpatrick JAJ, Shi PY, Diamond MS, Whelan SPJ, Ellebedy AH, Fremont DH
Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity.
1. Blood - published October 7, 2021
2. Park J, Daniels J, Wartewig T, Ringbloom KG, Martinez-Escala ME, Choi S, Thomas JJ, Doukas PG, Yang J, Snowden C, Law C, Lee Y, Lee K, Zhang Y, Conran C, Tegtmeyer K, Mo SH, Pease DR, Jothishankar B, Kwok PY, Abdulla FR, Pro B, Louissaint A, Boggon TJ, Sosman J, Guitart J, Rao D, Ruland J, Choi J
Triple reassortment increases compatibility among viral ribonucleoprotein genes of contemporary avian and human influenza A viruses.
1. PLoS Pathog - published October 7, 2021
2. Waters K, Gao C, Ykema M, Han L, Voth L, Tao YJ, Wan XF
Mechanistic insights into gasdermin pore formation and regulation in pyroptosis.
1. J Mol Biol - published October 7, 2021
2. Wang C, Ruan J
Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.
1. Cell - published October 7, 2021
2. Tal N, Morehouse BR, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ, Sorek R
Domain-specific biochemical and serological characterization of SARS-CoV-2 nucleocapsid protein.
1. STAR Protoc - published October 7, 2021
2. Wu C, Qavi AJ, Moyle AB, Wagner ND, Hachim A, Kavian N, Cole AR, Sweeney-Gibbons J, Rohrs HW, Peiris JSM, Basler CF, Gross ML, Valkenburg SA, Farnsworth CW, Amarasinghe GK, Leung DW
The structural and functional workings of KEOPS.
1. Nucleic Acids Res - published October 6, 2021
2. Beenstock J, Sicheri F
Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly.
1. Nat Cell Biol - published October 6, 2021
2. Cereghetti G, Wilson-Zbinden C, Kissling VM, Diether M, Arm A, Yoo H, Piazza I, Saad S, Picotti P, Drummond DA, Sauer U, Dechant R, Peter M
Putting the Pieces Together: the Hair Cell Transduction Complex.
1. J Assoc Res Otolaryngol - published October 6, 2021
2. Holt JR, Tobin M, Elferich J, Gouaux E, Ballesteros A, Yan Z, Ahmed ZM, Nicolson T
Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.
1. Chem Sci - published October 6, 2021
2. Lee KY, Enomoto M, Gebregiworgis T, Gasmi-Seabrook GMC, Ikura M, Marshall CB
Structural origins of Escherichia coli RNA polymerase open promoter complex stability.
1. Proc Natl Acad Sci U S A - published October 5, 2021
2. Saecker RM, Chen J, Chiu CE, Malone B, Sotiris J, Ebrahim M, Yen LY, Eng ET, Darst SA
A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants.
1. mBio - published October 5, 2021
2. Haslwanter D, Dieterle ME, Wec AZ, O'Brien CM, Sakharkar M, Florez C, Tong K, Rappazzo CG, Lasso G, Vergnolle O, Wirchnianski AS, Bortz RH 3rd, Laudermilch E, Fels JM, Mengotto A, Malonis RJ, Georgiev GI, Quiroz JA, Wrapp D, Wang N, Dye KE, Barnhill J, Dye JM, McLellan JS, Daily JP, Lai JR, Herbert AS, Walker LM, Chandran K, Jangra RK
Expression and characterization of SARS-CoV-2 spike proteins.
1. Nat Protoc - published October 5, 2021
2. Schaub JM, Chou CW, Kuo HC, Javanmardi K, Hsieh CL, Goldsmith J, DiVenere AM, Le KC, Wrapp D, Byrne PO, Hjorth CK, Johnson NV, Ludes-Meyers J, Nguyen AW, Wang N, Lavinder JJ, Ippolito GC, Maynard JA, McLellan JS, Finkelstein IJ
Mechanisms of SARS-CoV-2 entry into cells.
1. Nat Rev Mol Cell Biol - published October 5, 2021
2. Jackson CB, Farzan M, Chen B, Choe H
PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice.
1. EMBO Rep - published October 4, 2021
2. Zhang X, Schuhmachers P, Mourão A, Giansanti P, Murer A, Thumann S, Kuklik-Roos C, Beer S, Hauck SM, Hammerschmidt W, Küppers R, Kuster B, Raab M, Strebhardt K, Sattler M, Münz C, Kempkes B
mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy.
1. J Am Soc Nephrol - published October 4, 2021
2. Schlingmann KP, Jouret F, Shen K, Nigam A, Arjona FJ, Dafinger C, Houillier P, Jones DP, Kleinerüschkamp F, Oh J, Godefroid N, Eltan M, Güran T, Burtey S, Parotte MC, König J, Braun A, Bos C, Serra MI, Rehmann H, Zwartkruis FJT, Renkema KY, Klingel K, Schulze-Bahr E, Schermer B, Bergmann C, Altmüller J, Thiele H, Beck BB, Dahan K, Sabatini D, Liebau MC, Vargas-Poussou R, Knoers NVAM, Konrad M, de Baaij JHF
Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
1. Protein Sci - published October 3, 2021
2. Hobbs HT, Shah NH, Badroos JM, Gee CL, Marqusee S, Kuriyan J
Classifying Liganded States in Heterogeneous Single-Particle Cryo-EM Datasets.
1. Microscopy (Oxf) - published October 3, 2021
2. Arnold WR, Asarnow D, Cheng Y
Dendrimer-Like Supramolecular Assembly of Proteins with a Tunable Size and Valency Through Stepwise Iterative Growth.
1. Adv Sci (Weinh) - published October 3, 2021
2. Bae JH, Kim HS, Kim G, Song JJ, Kim HS
Contributions of single-particle cryoelectron microscopy toward fighting COVID-19.
1. Trends Biochem Sci - published October 3, 2021
2. Rapp M, Shapiro L, Frank J
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.
1. Proc Natl Acad Sci U S A - published October 2, 2021
2. Mahoney M, Damalanka VC, Tartell MA, Chung DH, Lourenço AL, Pwee D, Mayer Bridwell AE, Hoffmann M, Voss J, Karmakar P, Azouz NP, Klingler AM, Rothlauf PW, Thompson CE, Lee M, Klampfer L, Stallings CL, Rothenberg ME, Pöhlmann S, Whelan SPJ, O'Donoghue AJ, Craik CS, Janetka JW
Discovery and mechanism of action of small molecule inhibitors of ceramidases.
1. Angew Chem Int Ed Engl - published October 2, 2021
2. Healey RD, Saied EM, Cong X, Karsai G, Gabellier L, Saint Paul J, Del Nero E, Jeannot S, Drapeau M, Fontanel S, Maurel D, Basu S, Leyrat C, Golebiowski J, Bossis G, Bechara C, Hornemann T, Arenz C, Granier S
High throughput screening identifies inhibitors for parvovirus B19 infection of human erythroid progenitor cells.
1. J Virol - published October 2, 2021
2. Ning K, Roy A, Cheng F, Xu P, Kleiboeker S, Escalante CR, Wang J, Qiu J
Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
1. J Med Chem - published October 2, 2021
2. Wittlinger F, Heppner DE, To C, Günther M, Shin BH, Rana JK, Schmoker AM, Beyett TS, Berger LM, Berger BT, Bauer N, Vasta JD, Corona CR, Robers MB, Knapp S, Jänne PA, Eck MJ, Laufer SA
Susceptibilities of human ACE2 genetic variants in coronavirus infection.
1. J Virol - published October 2, 2021
2. Ren W, Zhu Y, Lan J, Chen H, Wang Y, Shi H, Feng F, Chen DY, Close B, Zhao X, Wu J, Tian B, Yuan Z, Zhou D, Saeed M, Wang X, Zhang R, Ding Q
An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats.
1. NPJ Vaccines - published October 2, 2021
2. Langereis MA, Albulescu IC, Stammen-Vogelzangs J, Lambregts M, Stachura K, Miller S, Bosco-Lauth AM, Hartwig AE, Porter SM, Allen M, Mogler M, van Kuppeveld FJM, Bosch BJ, Vermeij P, de Groof A, Bowen RA, Davis R, Xu Z, Tarpey I
Congenital X-linked Neutropenia with Myelodysplasia and Somatic Tetraploidy due to a Germline Mutation in SEPT6.
1. Am J Hematol - published October 2, 2021
2. Renella R, Gagne K, Beauchamp E, Fogel J, Perlov A, Sola M, Schlaeger T, Hofmann I, Shimamura A, Ebert BL, Schmitz-Abe K, Markianos K, Murphy K, Sun L, Rockowitz S, Sliz P, Campagna DR, Springer TA, Bahl C, Agarwal S, Fleming MD, Williams DA
Publisher Correction: Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention.
1. Nat Commun - published October 2, 2021
2. Dumbović G, Braunschweig U, Langner HK, Smallegan M, Biayna J, Hass EP, Jastrzebska K, Blencowe B, Cech TR, Caruthers MH, Rinn JL
Single-molecule mechanical fingerprinting with DNA nanoswitch calipers.
1. Nat Nanotechnol - published October 2, 2021
2. Shrestha P, Yang D, Tomov TE, MacDonald JI, Ward A, Bergal HT, Krieg E, Cabi S, Luo Y, Nathwani B, Johnson-Buck A, Shih WM, Wong WP
RCSB Protein Data Bank: Celebrating 50 years of the PDB with new tools for understanding and visualizing biological macromolecules in 3D.
1. Protein Sci - published October 2, 2021
2. Burley SK, Bhikadiya C, Bi C, Bittrich S, Chen L, Crichlow GV, Duarte JM, Dutta S, Fayazi M, Feng Z, Flatt JW, Ganesan SJ, Goodsell DS, Ghosh S, Kramer Green R, Guranovic V, Henry J, Hudson BP, Lawson CL, Liang Y, Lowe R, Peisach E, Persikova I, Piehl DW, Rose Y, Sali A, Segura J, Sekharan M, Shao C, Vallat B, Voigt M, Westbrook JD, Whetstone S, Young JY, Zardecki C
Highly Accurate Filters to Flag Frequent Hitters in AlphaScreen Assays by Suggesting their Mechanism.
1. Mol Inform - published October 2, 2021
2. Ghosh D, Koch U, Hadian K, Sattler M, Tetko IV
Immunogenicity of In Vitro-Transcribed RNA.
1. Acc Chem Res - published October 2, 2021
2. Mu X, Hur S
Structural evidence for visual arrestin priming via complexation of phosphoinositols.
1. Structure - published October 2, 2021
2. Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD
AraC-type regulators HilC and RtsA are directly controlled by an intestinal fatty acid to regulate Salmonella invasion.
1. Mol Microbiol - published October 2, 2021
2. Chowdhury R, Pavinski Bitar PD, Adams MC, Chappie JS, Altier C
Aberrant RNA methylation triggers recruitment of an alkylation repair complex.
1. Mol Cell - published October 2, 2021
2. Tsao N, Brickner JR, Rodell R, Ganguly A, Wood M, Oyeniran C, Ahmad T, Sun H, Bacolla A, Zhang L, Lukinović V, Soll JM, Townley BA, Casanova AG, Tainer JA, He C, Vindigni A, Reynoird N, Mosammaparast N
NMR ¹H, ¹³C, ¹⁵N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation.
1. Biomol NMR Assign - published October 2, 2021
2. Sharma AK, Dyba M, Tonelli M, Smith B, Gillette WK, Esposito D, Nissley DV, McCormick F, Maciag AE
Prestin's conformational cycle underlies outer hair cell electromotility.
1. Nature - published October 2, 2021
2. Bavi N, Clark MD, Contreras GF, Shen R, Reddy BG, Milewski W, Perozo E
Structure of the Streptococcus pyogenes NADase translocation domain and its essential role in toxin binding to oropharyngeal keratinocytes.
1. J Bacteriol - published October 2, 2021
2. Velarde JJ, Piai A, Lichtenstein IJ, Lynskey NN, Chou JJ, Wessels MR
Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides.
1. Faraday Discuss - published October 2, 2021
2. Kratochvil HT, Newberry RW, Mensa B, Mravic M, DeGrado WF
Immunotargeting of Nanocrystals by SpyCatcher Conjugation of Engineered Antibodies.
1. ACS Nano - published October 2, 2021
2. Pedroso CCS, Mann VR, Zuberbühler K, Bohn MF, Yu J, Altoe V, Craik CS, Cohen BE
The role of water coordination in the pH-dependent gating of hAQP10.
1. Biochim Biophys Acta Biomembr - published October 2, 2021
2. Truelsen SF, Missel JW, Gotfryd K, Pedersen PA, Gourdon P, Lindorff-Larsen K, Hélix-Nielsen C
Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope.
1. NPJ Vaccines - published October 2, 2021
2. Abernathy ME, Gristick HB, Vielmetter J, Keeffe JR, Gnanapragasam PNP, Lee YE, Escolano A, Gautam R, Seaman MS, Martin MA, Nussenzweig MC, Bjorkman PJ
Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant.
1. Science - published October 2, 2021
2. Zhang J, Xiao T, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Walsh RM, Jr, Rits-Volloch S, Wesemann DR, Yang W, Seaman MS, Lu J, Chen B
Rafting through the palms: S-acylation of SARS-CoV-2 spike protein induces lipid reorganization.
1. Dev Cell - published October 2, 2021
2. Vilmen G, Banerjee A, Freed EO
Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways.
1. Nat Neurosci - published October 2, 2021
2. Zolin A, Cohn R, Pang R, Siliciano AF, Fairhall AL, Ruta V
GABRB3-related epilepsy: novel variants, clinical features and therapeutic implications.
1. J Neurol - published October 2, 2021
2. Yang Y, Zeng Q, Cheng M, Niu X, Xiangwei W, Gong P, Li W, Ma J, Zhang X, Yang X, Yang Z, Sun D, Zhou S, Liao J, Jiang Y, Zhang Y
Author Correction: Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly.
1. Nat Cell Biol - published October 2, 2021
2. Cereghetti G, Wilson-Zbinden C, Kissling VM, Diether M, Arm A, Yoo H, Piazza I, Saad S, Picotti P, Drummond DA, Sauer U, Dechant R, Peter M
Cryo-Electron Microscopy Structure and Interactions of the Human Cytomegalovirus gHgLgO Trimer with Platelet-Derived Growth Factor Receptor Alpha.
1. mBio - published October 2, 2021
2. Liu J, Vanarsdall A, Chen DH, Chin A, Johnson D, Jardetzky TS
Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.
1. Sci Adv - published October 2, 2021
2. St-Cyr D, Ceccarelli DF, Orlicky S, van der Sloot AM, Tang X, Kelso S, Moore S, James C, Posternak G, Coulombe-Huntington J, Bertomeu T, Marinier A, Sicheri F, Tyers M
Conserved Trigger Loop Histidine of RNA Polymerase II Functions as a Positional Catalyst Primarily through Steric Effects.
1. Biochemistry - published October 2, 2021
2. Palo MZ, Zhu J, Mishanina TV, Landick R
Dispatched uses Na⁺ flux to power release of lipid-modified Hedgehog.
1. Nature - published October 2, 2021
2. Wang Q, Asarnow DE, Ding K, Mann RK, Hatakeyama J, Zhang Y, Ma Y, Cheng Y, Beachy PA
AKIRIN2 controls the nuclear import of proteasomes in vertebrates.
1. Nature - published October 2, 2021
2. de Almeida M, Hinterndorfer M, Brunner H, Grishkovskaya I, Singh K, Schleiffer A, Jude J, Deswal S, Kalis R, Vunjak M, Lendl T, Imre R, Roitinger E, Neumann T, Kandolf S, Schutzbier M, Mechtler K, Versteeg GA, Haselbach D, Zuber J
Single Nucleotide Resolution RNA-Protein Cross-Linking Mass Spectrometry: A Simple Extension of the CLIR-MS Workflow.
1. Anal Chem - published October 2, 2021
2. Götze M, Sarnowski CP, de Vries T, Knörlein A, Allain FH, Hall J, Aebersold R, Leitner A
A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge.
1. NPJ Vaccines - published October 2, 2021
2. Wuertz KM, Barkei EK, Chen WH, Martinez EJ, Lakhal-Naouar I, Jagodzinski LL, Paquin-Proulx D, Gromowski GD, Swafford I, Ganesh A, Dong M, Zeng X, Thomas PV, Sankhala RS, Hajduczki A, Peterson CE, Kuklis C, Soman S, Wieczorek L, Zemil M, Anderson A, Darden J, Hernandez H, Grove H, Dussupt V, Hack H, de la Barrera R, Zarling S, Wood JF, Froude JW, Gagne M, Henry AR, Mokhtari EB, Mudvari P, Krebs SJ, Pekosz AS, Currier JR, Kar S, Porto M, Winn A, Radzyminski K, Lewis MG, Vasan S, Suthar M, Polonis VR, Matyas GR, Boritz EA, Douek DC, Seder RA, Daye SP, Rao M, Peel SA, Joyce MG, Bolton DL, Michael NL, Modjarrad K
Selective G protein signaling driven by substance P-neurokinin receptor dynamics.
1. Nat Chem Biol - published October 2, 2021
2. Harris JA, Faust B, Gondin AB, Dämgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A
Pan-ebolavirus protective therapy by two multifunctional human antibodies.
1. Cell - published October 2, 2021
2. Gilchuk P, Murin CD, Cross RW, Ilinykh PA, Huang K, Kuzmina N, Borisevich V, Agans KN, Geisbert JB, Zost SJ, Nargi RS, Sutton RE, Suryadevara N, Bombardi RG, Carnahan RH, Bukreyev A, Geisbert TW, Ward AB, Crowe JE Jr
Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations.
1. Nat Immunol - published October 2, 2021
2. Dussupt V, Sankhala RS, Mendez-Rivera L, Townsley SM, Schmidt F, Wieczorek L, Lal KG, Donofrio GC, Tran U, Jackson ND, Zaky WI, Zemil M, Tritsch SR, Chen WH, Martinez EJ, Ahmed A, Choe M, Chang WC, Hajduczki A, Jian N, Peterson CE, Rees PA, Rutkowska M, Slike BM, Selverian CN, Swafford I, Teng IT, Thomas PV, Zhou T, Smith CJ, Currier JR, Kwong PD, Rolland M, Davidson E, Doranz BJ, Mores CN, Hatziioannou T, Reiley WW, Bieniasz PD, Paquin-Proulx D, Gromowski GD, Polonis VR, Michael NL, Modjarrad K, Joyce MG, Krebs SJ
CST does not evict elongating telomerase but prevents initiation by ssDNA binding.
1. Nucleic Acids Res - published October 2, 2021
2. Zaug AJ, Lim CJ, Olson CL, Carilli MT, Goodrich KJ, Wuttke DS, Cech TR
The neuroprotective effects of Insulin-Like Growth Factor 1 via the Hippo/YAP signaling pathway are mediated by the PI3K/AKT cascade following cerebral ischemia/reperfusion injury.
1. Brain Res Bull - published October 2, 2021
2. Gong P, Zou Y, Zhang W, Tian Q, Han S, Xu Z, Chen Q, Wang X, Li M
Glycosylation and serological reactivity of an expression-enhanced SARS-CoV-2 viral spike mimetic.
1. J Mol Biol - published October 2, 2021
2. Chawla H, Jossi SE, Faustini SE, Samsudin F, Allen JD, Watanabe Y, Newby ML, Marcial-Juárez E, Lamerton RE, McLellan JS, Bond PJ, Richter AG, Cunningham AF, Crispin M
Protein-Ligand Binding Molecular Details Revealed by Terahertz Optical Kerr Spectroscopy: A Simulation Study.
1. JACS Au - published October 2, 2021
2. Pan Z, Huang J, Zhuang W
In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.
1. ACS Cent Sci - published October 2, 2021
2. Zhao N, Bardine C, Lourenço AL, Wang YH, Huang Y, Cleary SJ, Wilson DM, Oh DY, Fong L, Looney MR, Evans MJ, Craik CS
RCSB Protein Data Bank resources for structure-facilitated design of mRNA vaccines for existing and emerging viral pathogens.
1. Structure - published October 2, 2021
2. Goodsell DS, Burley SK
The GPCR-β-arrestin complex allosterically activates C-Raf by binding its amino-terminus.
1. J Biol Chem - published October 2, 2021
2. Zang Y, Kahsai AW, Pakharukova N, Huang LY, Lefkowitz RJ
Systematic Profiling of Temperature- and Retinal-Sensitive Rhodopsin Variants by Deep Mutational Scanning.
1. J Biol Chem - published October 2, 2021
2. McKee AG, Kuntz CP, Ortega JT, Woods H, Most V, Roushar FJ, Meiler J, Jastrzebska B, Schlebach JP
An uncommon [K⁺(Mg²⁺)₂] metal ion triad imparts stability and selectivity to the Guanidine-I riboswitch.
1. RNA - published October 1, 2021
2. Trachman RJ 3rd, Ferré-D'Amaré AR
Emerging roles of Sirtuin 2 in cardiovascular diseases.
1. FASEB J - published October 1, 2021
2. Taneja A, Ravi V, Hong JY, Lin H, Sundaresan NR
The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases.
1. Science - published October 1, 2021
2. Altae-Tran H, Kannan S, Demircioglu FE, Oshiro R, Nety SP, McKay LJ, Dlakić M, Inskeep WP, Makarova KS, Macrae RK, Koonin EV, Zhang F
The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes.
1. Science - published October 1, 2021
2. Tran NH, Carter SD, De Mazière A, Ashkenazi A, Klumperman J, Walter P, Jensen GJ
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
1. Science - published October 1, 2021
2. Swaney DL, Ramms DJ, Wang Z, Park J, Goto Y, Soucheray M, Bhola N, Kim K, Zheng F, Zeng Y, McGregor M, Herrington KA, O'Keefe R, Jin N, VanLandingham NK, Foussard H, Von Dollen J, Bouhaddou M, Jimenez-Morales D, Obernier K, Kreisberg JF, Kim M, Johnson DE, Jura N, Grandis JR, Gutkind JS, Ideker T, Krogan NJ
Multiplexed Single-Molecule Experiments Reveal Nucleosome Invasion Dynamics of the Cas9 Genome Editor.
1. J Am Chem Soc - published October 1, 2021
2. Makasheva K, Bryan LC, Anders C, Panikulam S, Jinek M, Fierz B
Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogues.
1. Chem Commun (Camb) - published October 1, 2021
2. Dowman LJ, Agten SM, Ripoll-Rozada J, Calisto BM, Pereira PJB, Payne RJ
Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3).
1. J Med Chem - published October 1, 2021
2. Rietz TA, Teuscher KB, Mills JJ, Gogliotti RD, Lepovitz LT, Scaggs WR, Yoshida K, Luong K, Lee T, Fesik SW
The Atlas of Bacterial & Archaeal Cell Structure: an Interactive Open-Access Microbiology Textbook.
1. J Microbiol Biol Educ - published October 1, 2021
2. Oikonomou CM, Jensen GJ
Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5-Tetrahydrobenzo[F][1,4]oxazepines as Potential New Trypanocidal Agents.
1. J Chem Inf Model - published October 1, 2021
2. Fino R, Lenhart D, Kalel VC, Softley CA, Napolitano V, Byrne R, Schliebs W, Dawidowski M, Erdmann R, Sattler M, Schneider G, Plettenburg O, Popowicz GM
Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses.
1. Circ Genom Precis Med - published October 1, 2021
2. Wang M, Lee-Kim VS, Atri DS, Elowe NH, Yu J, Garvie CW, Won HH, Hadaya JE, MacDonald BT, Trindade K, Melander O, Rader DJ, Natarajan P, Kathiresan S, Kaushik VK, Khera AV, Gupta RM
NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner.
1. Cell Death Discov - published October 1, 2021
2. Huang C, Santofimia-Castaño P, Liu X, Xia Y, Peng L, Gotorbe C, Neira JL, Tang D, Pouyssegur J, Iovanna J
Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.
1. Nat Commun - published October 1, 2021
2. Dudas G, Hong SL, Potter BI, Calvignac-Spencer S, Niatou-Singa FS, Tombolomako TB, Fuh-Neba T, Vickos U, Ulrich M, Leendertz FH, Khan K, Huber C, Watts A, Olendraitė I, Snijder J, Wijnant KN, Bonvin AMJJ, Martres P, Behillil S, Ayouba A, Maidadi MF, Djomsi DM, Godwe C, Butel C, Šimaitis A, Gabrielaitė M, Katėnaitė M, Norvilas R, Raugaitė L, Koyaweda GW, Kandou JK, Jonikas R, Nasvytienė I, Žemeckienė Ž, Gečys D, Tamušauskaitė K, Norkienė M, Vasiliūnaitė E, Žiogienė D, Timinskas A, Šukys M, Šarauskas M, Alzbutas G, Aziza AA, Lusamaki EK, Cigolo JM, Mawete FM, Lofiko EL, Kingebeni PM, Tamfum JM, Belizaire MRD, Essomba RG, Assoumou MCO, Mboringong AB, Dieng AB, Juozapaitė D, Hosch S, Obama J, Ayekaba MO, Naumovas D, Pautienius A, Rafaï CD, Vitkauskienė A, Ugenskienė R, Gedvilaitė A, Čereškevičius D, Lesauskaitė V, Žemaitis L, Griškevičius L, Baele G
Structural characterization of DynU16, a START/Bet v1-like protein involved in dynemicin biosynthesis.
1. Acta Crystallogr F Struct Biol Commun - published October 1, 2021
2. Alvarado SK, Miller MD, Bhardwaj M, Thorson JS, Van Lanen SG, Phillips GN Jr
Differentiable biology: using deep learning for biophysics-based and data-driven modeling of molecular mechanisms.
1. Nat Methods - published October 1, 2021
2. AlQuraishi M, Sorger PK
Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies).
1. Proc Natl Acad Sci U S A - published October 1, 2021
2. Wu X, Rapoport TA
The structural basis of PTEN regulation by multi-site phosphorylation.
1. Nat Struct Mol Biol - published October 1, 2021
2. Dempsey DR, Viennet T, Iwase R, Park E, Henriquez S, Chen Z, Jeliazkov JR, Palanski BA, Phan KL, Coote P, Gray JJ, Eck MJ, Gabelli SB, Arthanari H, Cole PA
A structural model of a Ras-Raf signalosome.
1. Nat Struct Mol Biol - published October 1, 2021
2. Mysore VP, Zhou ZW, Ambrogio C, Li L, Kapp JN, Lu C, Wang Q, Tucker MR, Okoro JJ, Nagy-Davidescu G, Bai X, Plückthun A, Jänne PA, Westover KD, Shan Y, Shaw DE
The AAA+ superfamily: a review of the structural and mechanistic principles of these molecular machines.
1. Crit Rev Biochem Mol Biol - published October 1, 2021
2. Khan YA, White KI, Brunger AT
Critical discussion on drug efflux in Mycobacterium tuberculosis.
1. FEMS Microbiol Rev - published October 1, 2021
2. Remm S, Earp JC, Dick T, Dartois V, Seeger MA
Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection.
1. mBio - published October 1, 2021
2. Wessel AW, Doyle MP, Engdahl TB, Rodriguez J, Crowe JE Jr, Diamond MS
Structural basis of chromatin regulation by histone variant H2A.Z.
1. Nucleic Acids Res - published October 1, 2021
2. Lewis TS, Sokolova V, Jung H, Ng H, Tan D
Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription.
1. Cell Rep - published October 1, 2021
2. Pei J, Beri NR, Zou AJ, Hubel P, Dorando HK, Bergant V, Andrews RD, Pan J, Andrews JM, Sheehan KCF, Pichlmair A, Amarasinghe GK, Brody SL, Payton JE, Leung DW
Perturbing HIV-1 ribosomal frameshifting frequency reveals a cis preference for Gag-Pol incorporation into assembling virions.
1. J Virol - published October 1, 2021
2. Benner BE, Bruce JW, Kentala JR, Murray M, Becker JT, Garcia-Miranda P, Ahlquist P, Butcher SE, Sherer NM
Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor.
1. Nature - published October 1, 2021
2. Basore K, Ma H, Kafai NM, Mackin S, Kim AS, Nelson CA, Diamond MS, Fremont DH
Systems-level effects of allosteric perturbations to a model molecular switch.
1. Nature - published October 1, 2021
2. Perica T, Mathy CJP, Xu J, Jang GΜ, Zhang Y, Kaake R, Ollikainen N, Braberg H, Swaney DL, Lambright DG, Kelly MJS, Krogan NJ, Kortemme T
Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.
1. Nucleic Acids Res - published October 1, 2021
2. Schlegel MK, Matsuda S, Brown CR, Harp JM, Barry JD, Berman D, Castoreno A, Schofield S, Szeto J, Manoharan M, Charissé K, Egli M, Maier MA
Replication and single-cycle delivery of SARS-CoV-2 replicons.
1. Science - published October 1, 2021
2. Ricardo-Lax I, Luna JM, Thao TTN, Le Pen J, Yu Y, Hoffmann HH, Schneider WM, Razooky BS, Fernandez-Martinez J, Schmidt F, Weisblum Y, Trüeb BS, Berenguer Veiga I, Schmied K, Ebert N, Michailidis E, Peace A, Sánchez-Rivera FJ, Lowe SW, Rout MP, Hatziioannou T, Bieniasz PD, Poirier JT, MacDonald MR, Thiel V, Rice CM
The cellular environment shapes the nuclear pore complex architecture.
1. Nature - published October 1, 2021
2. Schuller AP, Wojtynek M, Mankus D, Tatli M, Kronenberg-Tenga R, Regmi SG, Dip PV, Lytton-Jean AKR, Brignole EJ, Dasso M, Weis K, Medalia O, Schwartz TU
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses.
1. Sci Immunol - published October 1, 2021
2. Feldman J, Bals J, Altomare CG, St Denis K, Lam EC, Hauser BM, Ronsard L, Sangesland M, Bracamonte Moreno T, Okonkwo V, Hartojo N, Balazs AB, Bajic G, Lingwood D, Schmidt AG
Prefused lysosomes cluster on autophagosomes regulated by VAMP8.
1. Cell Death Dis - published October 1, 2021
2. Chen Q, Hao M, Wang L, Li L, Chen Y, Shao X, Tian Z, Pfuetzner RA, Zhong Q, Brunger AT, Guan JL, Diao J
Lung cancer driven by BRAF^G469V mutation is targetable by EGFR kinase inhibitors.
1. J Thorac Oncol - published October 1, 2021
2. Huo KG, Notsuda H, Fang Z, Liu NF, Gebregiworgis T, Li Q, Pham NA, Li M, Liu N, Shepherd FA, Marshall CB, Ikura M, Moghal N, Tsao MS
Correction to: An automated iterative approach for protein structure refinement using pseudocontact shifts.
1. J Biomol NMR - published October 1, 2021
2. Cucuzza S, Güntert P, Plückthun A, Zerbe O
Biochemical Investigation of an N-acetyltransferase from Helicobacter pullorum.
1. Protein Sci - published October 1, 2021
2. Griffiths WA, Spencer KD, Thoden JB, Holden HM
Author Correction: Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses.
1. Nat Commun - published October 1, 2021
2. Alvarado G, Salmen W, Ettayebi K, Hu L, Sankaran B, Estes MK, Venkataram Prasad BV, Crowe JE Jr
Early cross-coronavirus reactive signatures of humoral immunity against COVID-19.
1. Sci Immunol - published October 1, 2021
2. Kaplonek P, Wang C, Bartsch Y, Fischinger S, Gorman MJ, Bowman K, Kang J, Dayal D, Martin P, Nowak RP, Villani AC, Hsieh CL, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Rojas-Lopez M, Russo BC, Sharma N, Tantivit J, Thomas MF, Sade-Feldman M, Feldman J, Julg B, Nilles EJ, Musk ER, Menon AS, Fischer ES, McLellan JS, Schmidt A, Goldberg MB, Filbin MR, Hacohen N, Lauffenburger DA, Alter G
miR-1 sustains muscle physiology by controlling V-ATPase complex assembly.
1. Sci Adv - published October 1, 2021
2. Gutiérrez-Pérez P, Santillán EM, Lendl T, Wang J, Schrempf A, Steinacker TL, Asparuhova M, Brandstetter M, Haselbach D, Cochella L
Scalable Nucleic Acid Storage and Retrieval Using Barcoded Microcapsules.
1. ACS Appl Mater Interfaces - published October 1, 2021
2. Banal JL, Bathe M
Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo.
1. J Med Chem - published October 1, 2021
2. Jones JH, Xin Z, Himmelbauer M, Dechantsreiter M, Enyedy I, Hedde J, Fang T, Coomaraswamy J, King KW, Murugan P, Santoro JC, Hesson T, Walther DM, Wei R, Zheng F, Marcotte DJ, Spilker K, Kumar PR, Liu Y, Gilfillan R, Gonzalez-Lopez de Turiso F
SMARCAD1 is an ATP-dependent histone octamer exchange factor with de novo nucleosome assembly activity.
1. Sci Adv - published October 1, 2021
2. Markert J, Zhou K, Luger K
Role of the major determinant of polar flagellation FlhG in the endoflagella-containing spirochete Leptospira.
1. Mol Microbiol - published October 1, 2021
2. Fule L, Halifa R, Fontana C, Sismeiro O, Legendre R, Varet H, Coppée JY, Murray GL, Adler B, Hendrixson DR, Buschiazzo A, Guo S, Liu J, Picardeau M
Characterization of Deposits in Calcific Tendinitis of the Shoulder: Deposits Are Composed of Large Aggregates of Highly Crystalline, Rod-Like Crystals.
1. Orthop J Sports Med - published October 1, 2021
2. Mateos JM, Singer G, Kaech A, Ziegler U, Eid K
Diethylpyrocarbonate Footprints a Membrane Protein in Micelles.
1. J Am Soc Mass Spectrom - published October 1, 2021
2. Guo C, Cheng M, Li W, Gross ML
Molecular insights into mechanisms of GPCR hijacking by Staphylococcus aureus.
1. Proc Natl Acad Sci U S A - published October 1, 2021
2. Grison CM, Lambey P, Jeannot S, Del Nero E, Fontanel S, Peysson F, Heuninck J, Sounier R, Durroux T, Leyrat C, Granier S, Bechara C
Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics.
1. Chem Rev - published October 1, 2021
2. Liu Y, Li Y, Koo S, Sun Y, Liu Y, Liu X, Pan Y, Zhang Z, Du M, Lu S, Qiao X, Gao J, Wang X, Deng Z, Meng X, Xiao Y, Kim JS, Hong X
Cryo-EM structure of human Pol κ bound to DNA and mono-ubiquitylated PCNA.
1. Nat Commun - published October 1, 2021
2. Lancey C, Tehseen M, Bakshi S, Percival M, Takahashi M, Sobhy MA, Raducanu VS, Blair K, Muskett FW, Ragan TJ, Crehuet R, Hamdan SM, De Biasio A
A Conversation with Dr. K. Christopher Garcia.
1. J Interferon Cytokine Res - published October 1, 2021
2. Garcia KC
Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome.
1. Cell - published October 1, 2021
2. Shen C, Li R, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S, Wu H
The Department of Veterans Affairs Gulf War Veterans' Illnesses Biorepository: Supporting Research on Gulf War Veterans' Illnesses.
1. Brain Sci - published October 1, 2021
2. Brady CB, Robey I, Stein TD, Huber BR, Riley J, Abdul Rauf N, Spencer KR, Walt G, Adams L, Averill JG, Walker S, McKee AC, Thomson SP, Kowall NW
ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.
1. Cell Rep - published October 1, 2021
2. Shi F, Mendrola JM, Sheetz JB, Wu N, Sommer A, Speer KF, Noordermeer JN, Kan ZY, Perry K, Englander SW, Stayrook SE, Fradkin LG, Lemmon MA
Space Power in Inclusive Development: Industrial Clusters and Rural Anti-Poverty.
1. Int J Environ Res Public Health - published October 1, 2021
2. Wu J, Liu X, Ruan J, Qi X, Wang C, Fan D
High Resolution Structure of the Mature Capsid of Ralstonia solanacearum Bacteriophage ϕRSA1 by Cryo-Electron Microscopy.
1. Int J Mol Sci - published October 1, 2021
2. Effantin G, Fujiwara A, Kawasaki T, Yamada T, Schoehn G
Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function.
1. Cell Rep - published October 1, 2021
2. Blockus H, Rolotti SV, Szoboszlay M, Peze-Heidsieck E, Ming T, Schroeder A, Apostolo N, Vennekens KM, Katsamba PS, Bahna F, Mannepalli S, Ahlsen G, Honig B, Shapiro L, de Wit J, Losonczy A, Polleux F
How Antibodies Recognize Pathogenic Viruses: Structural Correlates of Antibody Neutralization of HIV-1, SARS-CoV-2, and Zika.
1. Viruses - published October 1, 2021
2. Abernathy ME, Dam KA, Esswein SR, Jette CA, Bjorkman PJ
Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.
1. Neuron - published October 1, 2021
2. Xue J, Han Y, Zeng W, Jiang Y
Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain.
1. Cell Rep - published October 1, 2021
2. Cerutti G, Guo Y, Wang P, Nair MS, Wang M, Huang Y, Yu J, Liu L, Katsamba PS, Bahna F, Reddem ER, Kwong PD, Ho DD, Sheng Z, Shapiro L
Stabilized coronavirus spike stem elicits a broadly protective antibody.
1. Cell Rep - published October 1, 2021
2. Hsieh CL, Werner AP, Leist SR, Stevens LJ, Falconer E, Goldsmith JA, Chou CW, Abiona OM, West A, Westendorf K, Muthuraman K, Fritch EJ, Dinnon KH 3rd, Schäfer A, Denison MR, Chappell JD, Baric RS, Graham BS, Corbett KS, McLellan JS