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173 Member Publications for September 2020

Cryo-EM structures reveal two distinct conformational states in a picornavirus cell entry intermediate.
1. PLoS Pathog - published September 30, 2020
2. Shah PNM, Filman DJ, Karunatilaka KS, Hesketh EL, Groppelli E, Strauss M, Hogle JM
Breakage of the Oligomeric CaMKII Hub by the Regulatory Segment of the Kinase.
1. Elife - published September 9, 2020
2. Karandur D, Bhattacharyya M, Xia Z, Lee YK, Muratcioglu S, McAffee D, McSpadden E, Qiu B, Groves JT, Williams ER, Kuriyan J
High seroprevalence of anti-SARS-CoV-2 antibodies in Chelsea, Massachusetts.
1. J Infect Dis - published September 9, 2020
2. Naranbhai V, Chang CC, Beltran WFG, Miller TE, Astudillo MG, Villalba JA, Yang D, Gelfand J, Bernstein BE, Feldman J, Hauser BM, Caradonna TM, Alter G, Murali MR, Jasrasaria R, Quinlan J, Xerras DC, Betancourt JR, Louis DN, Schmidt AG, Lennerz J, Poznansky MC, Iafrate AJ
Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch.
1. Proc Natl Acad Sci U S A - published September 9, 2020
2. Gaubitz C, Liu X, Magrino J, Stone NP, Landeck J, Hedglin M, Kelch BA
SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation.
1. Nat Struct Mol Biol - published September 9, 2020
2. Schubert K, Karousis ED, Jomaa A, Scaiola A, Echeverria B, Gurzeler LA, Leibundgut M, Thiel V, Mühlemann O, Ban N
The native structure of the assembled matrix protein 1 of influenza A virus.
1. Nature - published September 9, 2020
2. Peukes J, Xiong X, Erlendsson S, Qu K, Wan W, Calder LJ, Schraidt O, Kummer S, Freund SMV, Kräusslich HG, Briggs JAG
Two-Step Testing for Clostridioides Difficile is Inadequate in Differentiating Infection From Colonization in Children.
1. J Pediatr Gastroenterol Nutr - published September 9, 2020
2. Parnell JM, Fazili I, Bloch SC, Lacy DB, Garcia-Lopez VA, Bernard R, Skaar EP, Edwards KM, Nicholson MR
Enhanced SARS-CoV-2 Neutralization by Secretory IgA in vitro.
1. bioRxiv - published September 9, 2020
2. Wang Z, Lorenzi JCC, Muecksch F, Finkin S, Viant C, Gaebler C, Cipolla M, Hoffman HH, Oliveira TY, Oren DA, Ramos V, Nogueira L, Michailidis E, Robbiani DF, Gazumyan A, Rice CM, Hatziioannou T, Bieniasz PD, Caskey M, Nussenzweig MC
Synthetic half-reactions.
1. Chem Sci - published September 9, 2020
2. Yudin AK
An International Multicenter Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of CASQ2-Catecholaminergic Polymorphic Ventricular Tachycardia.
1. Circulation - published September 8, 2020
2. Ng K, Titus EW, Lieve KV, Roston TM, Mazzanti A, Deiter FH, Denjoy I, Ingles J, Till J, Robyns T, Connors SP, Steinberg C, Abrams DJ, Pang B, Scheinman MM, Bos JM, Duffett SA, van der Werf C, Maltret A, Green MS, Rutberg J, Balaji S, Cadrin-Tourigny J, Orland KM, Knight LM, Brateng C, Wu J, Tang AS, Skanes AC, Manlucu J, Healey JS, January CT, Krahn AD, Collins KK, Maginot KR, Fischbach P, Etheridge SP, Eckhardt LL, Hamilton RM, Ackerman MJ, Noguer FRI, Semsarian C, Jura N, Leenhardt A, Gollob MH, Priori SG, Sanatani S, Wilde AAM, Deo RC, Roberts JD
Structure-Based Rational Design of Two Enhanced Bacterial Lipocalin Blc Tags for Protein-PAINT Super-resolution Microscopy.
1. ACS Chem Biol - published September 8, 2020
2. Muslinkina L, Gavrikov AS, Bozhanova NG, Mishin AS, Baranov MS, Meiler J, Pletneva NV, Pletnev VZ, Pletnev S
Suptavumab for the Prevention of Medically Attended Respiratory Syncytial Virus Infection in Preterm Infants.
1. Clin Infect Dis - published September 8, 2020
2. Simões EAF, Forleo-Neto E, Geba GP, Kamal M, Yang F, Cicirello H, Houghton MR, Rideman R, Zhao Q, Benvin SL, Hawes A, Fuller ED, Wloga E, Pizarro JMN, Munoz FM, Rush SA, McLellan JS, Lipsich L, Stahl N, Yancopoulos GD, Weinreich DM, Kyratsous CA, Sivapalasingam S
Ultra-sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease.
1. Clin Chem - published September 8, 2020
2. Ogata AF, Maley AM, Wu C, Gilboa T, Norman M, Lazarovits R, Mao CP, Newton G, Chang M, Nguyen K, Kamkaew M, Zhu Q, Gibson TE, Ryan ET, Charles RC, Marasco WA, Walt DR
Who are the Researchers? Where are the Librarians?
1. Res Synth Methods - published September 8, 2020
2. Goldberg J, Godwin K, Boyce L
HDAC3 deacetylates the DNA mismatch repair factor MutSβ to stimulate triplet repeat expansions.
1. Proc Natl Acad Sci U S A - published September 8, 2020
2. Williams GM, Paschalis V, Ortega J, Muskett FW, Hodgkinson JT, Li GM, Schwabe JWR, Lahue RS
Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes.
1. Proc Natl Acad Sci U S A - published September 8, 2020
2. Painter MM, Zimmerman GE, Merlino MS, Robertson AW, Terry VH, Ren X, McLeod MR, Gomez-Rodriguez L, Garcia KA, Leonard JA, Leopold KE, Neevel AJ, Lubow J, Olson E, Piechocka-Trocha A, Collins DR, Tripathi A, Raghavan M, Walker BD, Hurley JH, Sherman DH, Collins KL
The Structure of the Cysteine-Rich Domain of Plasmodium falciparum P113 Identifies the Location of the RH5 Binding Site.
1. mBio - published September 8, 2020
2. Campeotto I, Galaway F, Mehmood S, Barfod LK, Quinkert D, Kotraiah V, Phares TW, Wright KE, Snijders AP, Draper SJ, Higgins MK, Wright GJ
Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism.
1. J Cell Biol - published September 7, 2020
2. Khalaj AJ, Sterky FH, Sclip A, Schwenk J, Brunger AT, Fakler B, Südhof TC
The pseudoGTPase group of pseudoenzymes.
1. FEBS J - published September 7, 2020
2. Stiegler AL, Boggon TJ
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation.
1. Nat Cell Biol - published September 7, 2020
2. Daneshvar K, Ardehali MB, Klein IA, Hsieh FK, Kratkiewicz AJ, Mahpour A, Cancelliere SOL, Zhou C, Cook BM, Li W, Pondick JV, Gupta SK, Moran SP, Young RA, Kingston RE, Mullen AC
Discovery of Covalent MKK4/7 Dual Inhibitor.
1. Cell Chem Biol - published September 7, 2020
2. Jiang J, Jiang B, He Z, Ficarro SB, Che J, Marto JA, Gao Y, Zhang T, Gray NS
Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo.
1. Nucleic Acids Res - published September 5, 2020
2. Shao Z, Lee BJ, Rouleau-Turcotte É, Langelier MF, Lin X, Estes VM, Pascal JM, Zha S
Beyond Shielding: The Roles of Glycans in SARS-CoV-2 Spike Protein.
1. bioRxiv - published September 4, 2020
2. Casalino L, Gaieb Z, Goldsmith JA, Hjorth CK, Dommer AC, Harbison AM, Fogarty CA, Barros EP, Taylor BC, McLellan JS, Fadda E, Amaro RE
Transcriptional interference at tandem lncRNA and protein-coding genes: an emerging theme in regulation of cellular nutrient homeostasis.
1. Nucleic Acids Res - published September 4, 2020
2. Shuman S
Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
1. MAbs - published September 4, 2020
2. Austin M, Burschowsky D, Chan DTY, Jenkinson L, Haynes S, Diamandakis A, Seewooruthun C, Addyman A, Fiedler S, Ryman S, Whitehouse J, Slater LH, Hadjinicolaou AV, Gileadi U, Gowans E, Shibata Y, Barnard M, Kaserer T, Sharma P, Luheshi NM, Wilkinson RW, Vaughan TJ, Holt SV, Cerundolo V, Carr MD, Groves MAT
The gammaherpesviral TATA-box-binding protein directly interacts with the CTD of host RNA Pol II to direct late gene transcription.
1. PLoS Pathog - published September 4, 2020
2. Castañeda AF, Didychuk AL, Louder RK, McCollum CO, Davis ZH, Nogales E, Glaunsinger BA
Msp1/ATAD1 in Protein Quality Control and Regulation of Synaptic Activities.
1. Annu Rev Cell Dev Biol - published September 4, 2020
2. Wang L, Walter P
A defined structural unit enables de novo design of small-molecule-binding proteins.
1. Science - published September 4, 2020
2. Polizzi NF, DeGrado WF
2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales.
1. Arch Virol - published September 4, 2020
2. Kuhn JH, Adkins S, Alioto D, Alkhovsky SV, Amarasinghe GK, Anthony SJ, Avšič-Županc T, Ayllón MA, Bahl J, Balkema-Buschmann A, Ballinger MJ, Bartonička T, Basler C, Bavari S, Beer M, Bente DA, Bergeron É, Bird BH, Blair C, Blasdell KR, Bradfute SB, Breyta R, Briese T, Brown PA, Buchholz UJ, Buchmeier MJ, Bukreyev A, Burt F, Buzkan N, Calisher CH, Cao M, Casas I, Chamberlain J, Chandran K, Charrel RN, Chen B, Chiumenti M, Choi IR, Clegg JCS, Crozier I, da Graça JV, Dal Bó E, Dávila AMR, de la Torre JC, de Lamballerie X, de Swart RL, Di Bello PL, Di Paola N, Di Serio F, Dietzgen RG, Digiaro M, Dolja VV, Dolnik O, Drebot MA, Drexler JF, Dürrwald R, Dufkova L, Dundon WG, Duprex WP, Dye JM, Easton AJ, Ebihara H, Elbeaino T, Ergünay K, Fernandes J, Fooks AR, Formenty PBH, Forth LF, Fouchier RAM, Freitas-Astúa J, Gago-Zachert S, Gāo GF, García ML, García-Sastre A, Garrison AR, Gbakima A, Goldstein T, Gonzalez JJ, Griffiths A, Groschup MH, Günther S, Guterres A, Hall RA, Hammond J, Hassan M, Hepojoki J, Hepojoki S, Hetzel U, Hewson R, Hoffmann B, Hongo S, Höper D, Horie M, Hughes HR, Hyndman TH, Jambai A, Jardim R, Jiāng D, Jin Q, Jonson GB, Junglen S, Karadağ S, Keller KE, Klempa B, Klingström J, Kobinger G, Kondō H, Koonin EV, Krupovic M, Kurath G, Kuzmin IV, Laenen L, Lamb RA, Lambert AJ, Langevin SL, Lee B, Lemos ERS, Leroy EM, Li D, Lǐ J, Liang M, Liú W, Liú Y, Lukashevich IS, Maes P, Marciel de Souza W, Marklewitz M, Marshall SH, Martelli GP, Martin RR, Marzano SL, Massart S, McCauley JW, Mielke-Ehret N, Minafra A, Minutolo M, Mirazimi A, Mühlbach HP, Mühlberger E, Naidu R, Natsuaki T, Navarro B, Navarro JA, Netesov SV, Neumann G, Nowotny N, Nunes MRT, Nylund A, Økland AL, Oliveira RC, Palacios G, Pallas V, Pályi B, Papa A, Parrish CR, Pauvolid-Corrêa A, Pawęska JT, Payne S, Pérez DR, Pfaff F, Radoshitzky SR, Rahman AU, Ramos-González PL, Resende RO, Reyes CA, Rima BK, Romanowski V, Robles Luna G, Rota P, Rubbenstroth D, Runstadler JA, Ruzek D, Sabanadzovic S, Salát J, Sall AA, Salvato MS, Sarpkaya K, Sasaya T, Schwemmle M, Shabbir MZ, Shí X, Shí Z, Shirako Y, Simmonds P, Širmarová J, Sironi M, Smither S, Smura T, Song JW, Spann KM, Spengler JR, Stenglein MD, Stone DM, Straková P, Takada A, Tesh RB, Thornburg NJ, Tomonaga K, Tordo N, Towner JS, Turina M, Tzanetakis I, Ulrich RG, Vaira AM, van den Hoogen B, Varsani A, Vasilakis N, Verbeek M, Wahl V, Walker PJ, Wang H, Wang J, Wang X, Wang LF, Wèi T, Wells H, Whitfield AE, Williams JV, Wolf YI, Wú Z, Yang X, Yáng X, Yu X, Yutin N, Zerbini FM, Zhang T, Zhang YZ, Zhou G, Zhou X
The roles of SDHAF2 and dicarboxylate in covalent flavinylation of SDHA, the human complex II flavoprotein.
1. Proc Natl Acad Sci U S A - published September 4, 2020
2. Sharma P, Maklashina E, Cecchini G, Iverson TM
The Third Coiled Coil Domain of Atg11 Is Required for Shaping Mitophagy Initiation Sites.
1. J Mol Biol - published September 4, 2020
2. Margolis HK, Katzenell S, Leary KA, Ragusa MJ
Crystallographic Characterization of the Carbonylated A-Cluster in Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase.
1. ACS Catal - published September 4, 2020
2. Cohen SE, Can M, Wittenborn EC, Hendrickson RA, Ragsdale SW, Drennan CL
Genome-Wide Identification of Transcription Start Sites in Two Alphaproteobacteria, Rhodobacter sphaeroides 2.4.1 and Novosphingobium aromaticivorans DSM 12444.
1. Microbiol Resour Announc - published September 3, 2020
2. Myers KS, Vera JM, Lemmer KC, Linz AM, Landick R, Noguera DR, Donohue TJ
Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters.
1. Nat Med - published September 3, 2020
2. Tostanoski LH, Wegmann F, Martinot AJ, Loos C, McMahan K, Mercado NB, Yu J, Chan CN, Bondoc S, Starke CE, Nekorchuk M, Busman-Sahay K, Piedra-Mora C, Wrijil LM, Ducat S, Custers J, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Jacob-Dolan C, Lin Z, Mahrokhian SH, Nampanya F, Nityanandam R, Pessaint L, Porto M, Ali V, Benetiene D, Tevi K, Andersen H, Lewis MG, Schmidt AG, Lauffenburger DA, Alter G, Estes JD, Schuitemaker H, Zahn R, Barouch DH
SnapShot: β-Arrestin Functions.
1. Cell - published September 3, 2020
2. Ahn S, Shenoy SK, Luttrell LM, Lefkowitz RJ
SYLARAS: A Platform for the Statistical Analysis and Visual Display of Systemic Immunoprofiling Data and Its Application to Glioblastoma.
1. Cell Syst - published September 3, 2020
2. Baker GJ, Muhlich JL, Palaniappan SK, Moore JK, Davis SH, Santagata S, Sorger PK
Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2.
1. Cell Host Microbe - published September 3, 2020
2. Nielsen SCA, Yang F, Jackson KJL, Hoh RA, Röltgen K, Jean GH, Stevens BA, Lee JY, Rustagi A, Rogers AJ, Powell AE, Hunter M, Najeeb J, Otrelo-Cardoso AR, Yost KE, Daniel B, Nadeau KC, Chang HY, Satpathy AT, Jardetzky TS, Kim PS, Wang TT, Pinsky BA, Blish CA, Boyd SD
Collision-Induced Unfolding Differentiates Functional Variants of the KCNQ1 Voltage Sensor Domain.
1. J Am Soc Mass Spectrom - published September 3, 2020
2. Fantin SM, Huang H, Sanders CR, Ruotolo BT
EMPAS: Electron Microscopy Screening for Endogenous Protein Architectures.
1. Mol Cells - published September 3, 2020
2. Kim G, Jang S, Lee E, Song JJ
Accuracy of serological testing for SARS-CoV-2 antibodies: first results of a large mixed-method evaluation study.
1. Allergy - published September 3, 2020
2. Brigger D, Horn MP, Pennington LF, Powell AE, Siegrist D, Weber B, Engler O, Piezzi V, Damonti L, Iseli P, Hauser C, Froehlich TK, Villiger PM, Bachmann MF, Leib SL, Bittel P, Fiedler M, Largiadèr C, Marschall J, Stalder H, Kim PS, Jardetzky TS, Eggel A, Nagler M
The rapid "teabag" method for high-end purification of membrane proteins.
1. Sci Rep - published September 3, 2020
2. Hering J, Missel JW, Zhang L, Gunnarsson A, Castaldo M, Pedersen PA, Ek M, Gourdon P, Snijder HJ
Structural basis for pH gating of the two-pore domain K⁺ channel TASK2.
1. Nature - published September 3, 2020
2. Li B, Rietmeijer RA, Brohawn SG
Functional plasticity and evolutionary adaptation of allosteric regulation.
1. Proc Natl Acad Sci U S A - published September 3, 2020
2. Leander M, Yuan Y, Meger A, Cui Q, Raman S
A Survey of Genome Editing Activity for 16 Cas12a Orthologs.
1. Keio J Med - published September 2, 2020
2. Zetsche B, Abudayyeh OO, Gootenberg JS, Scott DA, Zhang F
HNK-1 sulfotransferase modulates α-dystroglycan glycosylation by 3-O-sulfation of glucuronic acid on matriglycan.
1. Glycobiology - published September 2, 2020
2. Sheikh MO, Venzke D, Anderson ME, Yoshida-Moriguchi T, Glushka JN, Nairn AV, Galizzi M, Moremen KW, Campbell KP, Wells L
Multimodal small-molecule screening for human prion protein binders.
1. J Biol Chem - published September 2, 2020
2. Reidenbach AG, Mesleh MF, Casalena D, Vallabh SM, Dahlin JL, Leed AJ, Chan AI, Usanov DL, Yehl JB, Lemke CT, Campbell AJ, Shah RN, Shrestha OK, Sacher JR, Rangel VL, Moroco JA, Sathappa M, Nonato MC, Nguyen KT, Wright SK, Liu DR, Wagner FF, Kaushik VK, Auld DS, Schreiber SL, Minikel EV
Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library.
1. ACS Chem Biol - published September 2, 2020
2. Powell CE, Du G, Che J, He Z, Donovan KA, Yue H, Wang ES, Nowak RP, Zhang T, Fischer ES, Gray NS
Structural analysis of the Legionella pneumophila Dot/Icm Type IV Secretion System Core Complex.
1. Elife - published September 2, 2020
2. Durie CL, Sheedlo MJ, Chung JM, Byrne BG, Su M, Knight T, Swanson M, Lacy DB, Ohi MD
Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex.
1. Elife - published September 2, 2020
2. Sheedlo MJ, Chung JM, Sawhney N, Durie CL, Cover TL, Ohi MD, Lacy DB
A way to thioacetate esters compatible with non-oxidative prebiotic conditions.
1. Sci Rep - published September 2, 2020
2. Leqraa N, Nicolet Y, Milet A, Vallée Y
An autoinhibitory role for the GRF zinc finger domain of DNA glycosylase NEIL3.
1. J Biol Chem - published September 2, 2020
2. Rodriguez AA, Wojtaszek JL, Greer BH, Haldar T, Gates KS, Williams RS, Eichman BF
Publisher Correction: SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.
1. Nat Immunol - published September 2, 2020
2. Winkler ES, Bailey AL, Kafai NM, Nair S, McCune BT, Yu J, Fox JM, Chen RE, Earnest JT, Keeler SP, Ritter JH, Kang LI, Dort S, Robichaud A, Head R, Holtzman MJ, Diamond MS
Properties of protein unfolded states suggest broad selection for expanded conformational ensembles.
1. Proc Natl Acad Sci U S A - published September 2, 2020
2. Bowman MA, Riback JA, Rodriguez A, Guo H, Li J, Sosnick TR, Clark PL
Probing the Conformational States of Neurotensin Receptor 1 Variants by NMR Site-Directed Methyl Labeling.
1. Chembiochem - published September 2, 2020
2. Goba I, Goricanec D, Schum D, Hillenbrand M, Plückthun A, Hagn F
An ABSINTH-Based Protocol for Predicting Binding Affinities between Proteins and Small Molecules.
1. J Chem Inf Model - published September 2, 2020
2. Marchand JR, Knehans T, Caflisch A, Vitalis A
Sapphire-Based Clustering.
1. J Chem Theory Comput - published September 2, 2020
2. Cocina F, Vitalis A, Caflisch A
Tuning the Baird aromatic triplet-state energy of cyclooctatetraene to maximize the self-healing mechanism in organic fluorophores.
1. Proc Natl Acad Sci U S A - published September 2, 2020
2. Pati AK, El Bakouri O, Jockusch S, Zhou Z, Altman RB, Fitzgerald GA, Asher WB, Terry DS, Borgia A, Holsey MD, Batchelder JE, Abeywickrama C, Huddle B, Rufa D, Javitch JA, Ottosson H, Blanchard SC
Genetically Encoded Quinone Methides Enabling Rapid, Site-Specific, and Photocontrolled Protein Modification with Amine Reagents.
1. J Am Chem Soc - published September 2, 2020
2. Liu J, Cheng R, Van Eps N, Wang N, Morizumi T, Ou WL, Klauser PC, Rozovsky S, Ernst OP, Wang L
Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps.
1. J Am Chem Soc - published September 2, 2020
2. Zhou XX, Bracken CJ, Zhang K, Zhou J, Mou Y, Wang L, Cheng Y, Leung KK, Wells JA
Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition.
1. bioRxiv - published September 2, 2020
2. Greaney AJ, Starr TN, Gilchuk P, Zost SJ, Binshtein E, Loes AN, Hilton SK, Huddleston J, Eguia R, Crawford KHD, Dingens AS, Nargi RS, Sutton RE, Suryadevara N, Rothlauf PW, Liu Z, Whelan SPJ, Carnahan RH, Crowe JE Jr, Bloom JD
Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics.
1. J Am Chem Soc - published September 2, 2020
2. Watkins LC, DeGrado WF, Voth GA
Substrate-Dependent Modulation of SIRT2 by a Fluorescent Probe, 1-Aminoanthracene.
1. Biochemistry - published September 2, 2020
2. Bi D, Yang J, Hong JY, Parikh P, Hinds N, Infanti J, Lin H, Weiser BP
Reply to Arora et al.: Concerns and considerations about using the CV as an equity tool.
1. Proc Natl Acad Sci U S A - published September 2, 2020
2. Malisch JL, Harris BN, Sherrer SM, Lewis KA, Shepherd SL, McCarthy PC, Spott JL, Karam EP, Moustaid-Moussa N, Calarco JM, Ramalingam L, Talley AE, Cañas-Carrell JE, Ardon-Dryer K, Weiser DA, Bernal XE, Deitloff J
Correction to: The role of NMR in leveraging dynamics and entropy in drug design.
1. J Biomol NMR - published September 2, 2020
2. Dubey A, Takeuchi K, Reibarkh M, Arthanari H
Assembly and Maintenance of Lipids at the Bacterial Outer Membrane.
1. Chem Rev - published September 2, 2020
2. Lundstedt E, Kahne D, Ruiz N
A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics.
1. J Vis Exp - published September 2, 2020
2. Ge Y, Boopathy S, Smith A, Chao LH
Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency.
1. J Clin Invest - published September 2, 2020
2. Bastard P, Manry J, Chen J, Rosain J, Seeleuthner Y, AbuZaitun O, Lorenzo L, Khan T, Hasek M, Hernandez N, Bigio B, Zhang P, Lévy R, Shrot S, Garcia Reino EJ, Lee YS, Boucherit S, Aubart M, Gijsbers R, Béziat V, Li Z, Pellegrini S, Meyts I, Rozenberg F, Marr N, Boisson B, Cobat A, Bustamante J, Zhang Q, Jouanguy E, Abel L, Somech R, Casanova JL, Zhang SY
Disulfide Exchange in von Willebrand factor Dimerization in the Golgi.
1. Blood - published September 2, 2020
2. Dong X, Springer TA
The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis.
1. PLoS Pathog - published September 2, 2020
2. Bilverstone TW, Garland M, Cave RJ, Kelly ML, Tholen M, Bouley DM, Kaye P, Minton NP, Bogyo M, Kuehne SA, Melnyk RA
Synthesis and antimicrobial evaluation of new nitric oxide-donating fluoroquinolone/oxime hybrids.
1. Arch Pharm (Weinheim) - published September 2, 2020
2. Aziz HA, Moustafa GAI, Abuo-Rahma GEA, Rabea SM, Hauk G, Krishna VS, Sriram D, Berger JM, Abbas SH
A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency.
1. Proc Natl Acad Sci U S A - published September 2, 2020
2. Daou S, Talukdar M, Tang J, Dong B, Banerjee S, Li Y, Duffy NM, Ogunjimi AA, Gaughan C, Jha BK, Gish G, Tavernier N, Mao D, Weiss SR, Huang H, Silverman RH, Sicheri F
NCBP3 positively impacts mRNA biogenesis.
1. Nucleic Acids Res - published September 2, 2020
2. Dou Y, Barbosa I, Jiang H, Iasillo C, Molloy KR, Schulze WM, Cusack S, Schmid M, Le Hir H, LaCava J, Jensen TH
Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.
1. Proc Natl Acad Sci U S A - published September 2, 2020
2. Choudhary D, Narui Y, Neel BL, Wimalasena LN, Klanseck CF, De-la-Torre P, Chen C, Araya-Secchi R, Tamilselvan E, Sotomayor M
Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM.
1. Prog Biophys Mol Biol - published September 2, 2020
2. Hammel M, Rosenberg DJ, Bierma J, Hura GL, Lees-Miller SP, Tainer JA
Synthetic group A streptogramin antibiotics that overcome Vat resistance.
1. Nature - published September 2, 2020
2. Li Q, Pellegrino J, Lee DJ, Tran AA, Chaires HA, Wang R, Park JE, Ji K, Chow D, Zhang N, Brilot AF, Biel JT, van Zundert G, Borrelli K, Shinabarger D, Wolfe C, Murray B, Jacobson MP, Mühle E, Chesneau O, Fraser JS, Seiple IB
Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico.
1. Nat Commun - published September 2, 2020
2. Broom A, Rakotoharisoa RV, Thompson MC, Zarifi N, Nguyen E, Mukhametzhanov N, Liu L, Fraser JS, Chica RA
Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.
1. Nature - published September 2, 2020
2. Xu D, Zhao H, Jin M, Zhu H, Shan B, Geng J, Dziedzic SA, Amin P, Mifflin L, Naito MG, Najafov A, Xing J, Yan L, Liu J, Qin Y, Hu X, Wang H, Zhang M, Manuel VJ, Tan L, He Z, Sun ZJ, Lee VMY, Wagner G, Yuan J
Protease protection assays show polypeptide movement into the SecY channel by power strokes of the SecA ATPase.
1. EMBO Rep - published September 2, 2020
2. Catipovic MA, Rapoport TA
POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan.
1. Elife - published September 2, 2020
2. Walimbe AS, Okuma H, Joseph S, Yang T, Yonekawa T, Hord JM, Venzke D, Anderson ME, Torelli S, Manzur A, Devereaux M, Cuellar M, Prouty S, Ocampo Landa S, Yu L, Xiao J, Dixon JE, Muntoni F, Campbell KP
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
1. Science - published September 2, 2020
2. Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann HH, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus AL, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen SZ, Alsohime F, Al Turki S, Hasanato R, van de Beek D, Biondi A, Bettini LR, D'Angio M, Bonfanti P, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Oler AJ, Tompkins MF, Alba C, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Soler-Palacin P, Martin-Nalda A, Colobran R, Morange PE, Keles S, Çölkesen F, Ozcelik T, Yasar KK, Senoglu S, Karabela ŞN, Gallego CR, Novelli G, Hraiech S, Tandjaoui-Lambiotte Y, Duval X, Laouénan C, COVID-STORM Clinicians., COVID Clinicians., Imagine COVID Group., French COVID Cohort Study Group., CoV-Contact Cohort., Amsterdam UMC Covid-19., Biobank., COVID Human Genetic Effort., NIAID-USUHS., TAGC COVID Immunity Group., Snow AL, Dalgard CL, Milner J, Vinh DC, Mogensen TH, Marr N, Spaan AN, Boisson B, Boisson-Dupuis S, Bustamante J, Puel A, Ciancanelli M, Meyts I, Maniatis T, Soumelis V, Amara A, Nussenzweig M, García-Sastre A, Krammer F, Pujol A, Duffy D, Lifton R, Zhang SY, Gorochov G, Béziat V, Jouanguy E, Sancho-Shimizu V, Rice CM, Abel L, Notarangelo LD, Cobat A, Su HC, Casanova JL
Human Antibodies Targeting Influenza B Virus Neuraminidase Active Site Are Broadly Protective.
1. Immunity - published September 2, 2020
2. Madsen A, Dai YN, McMahon M, Schmitz AJ, Turner JS, Tan J, Lei T, Alsoussi WB, Strohmeier S, Amor M, Mohammed BM, Mudd PA, Simon V, Cox RJ, Fremont DH, Krammer F, Ellebedy AH
Picky ABCG5/G8 and promiscuous ABCG2 - a tale of fatty diets and drug toxicity.
1. FEBS Lett - published September 2, 2020
2. Khunweeraphong N, Mitchell-White J, Szöllősi D, Hussein T, Kuchler K, Kerr ID, Stockner T, Lee JY
Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor.
1. J Med Chem - published September 2, 2020
2. Gunera J, Baker JG, van Hilten N, Rosenbaum DM, Kolb P
Transcriptional regulation of the N_ε -fructoselysine metabolism in Escherichia coli by global and substrate-specific cues.
1. Mol Microbiol - published September 2, 2020
2. von Armansperg BG, Koller F, Gericke N, Hellwig M, Jagtap PKA, Heermann R, Hennig J, Henle T, Lassak J
Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes.
1. J Biol Chem - published September 2, 2020
2. Pakharukova N, Masoudi A, Pani B, Staus DP, Lefkowitz RJ
Effects of antimicrobial photodynamic therapy on antibiotic-resistant Escherichia coli.
1. Photodiagnosis Photodyn Ther - published September 2, 2020
2. Garcez AS, Kaplan M, Jensen GJ, Scheidt FR, Oliveira EM, Suzuki SS
Characterization of Streptococcus pneumoniae PriA helicase and its ATPase and unwinding activities in DNA replication restart.
1. Biochem J - published September 2, 2020
2. Lin MG, Li YC, Hsiao CD
Whence Blobs? Phylogenetics of functional protein condensates.
1. Biochem Soc Trans - published September 2, 2020
2. Pritišanac I, Zarin T, Forman-Kay JD, Moses AM
Major Improvements in Robustness and Efficiency during the Screening of Novel Enzyme Effectors by the 3-Point Kinetics Assay.
1. SLAS Discov - published September 2, 2020
2. Pinto MF, Figueiredo F, Silva A, Pombinho AR, Pereira PJB, Macedo-Ribeiro S, Rocha F, Martins PM
The neuroligins and the synaptic pathway in Autism Spectrum Disorder.
1. Neurosci Biobehav Rev - published September 2, 2020
2. Trobiani L, Meringolo M, Diamanti T, Bourne Y, Marchot P, Martella G, Dini L, Pisani A, De Jaco A, Bonsi P
Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation.
1. J Biol Chem - published September 2, 2020
2. Nandi S, Razzaghi M, Srivastava D, Dey M
Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosine.
1. Nucleic Acids Res - published September 2, 2020
2. Mikami A, Erande N, Matsuda S, Kel'in A, Woods LB, Chickering T, Pallan PS, Schlegel MK, Zlatev I, Egli M, Manoharan M
SIRT1 is downregulated by autophagy in senescence and ageing.
1. Nat Cell Biol - published September 2, 2020
2. Xu C, Wang L, Fozouni P, Evjen G, Chandra V, Jiang J, Lu C, Nicastri M, Bretz C, Winkler JD, Amaravadi R, Garcia BA, Adams PD, Ott M, Tong W, Johansen T, Dou Z, Berger SL
Primary pulmonary vein stenosis among premature infants with single-vessel disease.
1. J Perinatol - published September 2, 2020
2. Zettler E, Rivera BK, Stiver C, Boe B, Cua C, Ball MK, Smith CV, Slaughter JL, Chen B, Callahan R, Backes CH
Characterization of tau binding by gosuranemab.
1. Neurobiol Dis - published September 2, 2020
2. Sopko R, Golonzhka O, Arndt J, Quan C, Czerkowicz J, Cameron A, Smith B, Murugesan Y, Gibbons G, Kim SJ, Trojanowski JQ, Lee VMY, Brunden KR, Weinreb PH, Graham DL, Hering H
Selective regulation of human TRAAK channels by biologically active phospholipids.
1. Nat Chem Biol - published September 2, 2020
2. Schrecke S, Zhu Y, McCabe JW, Bartz M, Packianathan C, Zhao M, Zhou M, Russell D, Laganowsky A
Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses.
1. bioRxiv - published September 2, 2020
2. Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano K, Hayashi JM, Carlson-Stevermer J, Oki J, Holden K, Krogan NJ, Ott M, Puschnik AS
Binding Mechanism Elucidation of the Acute Respiratory Disease Causing Agent Adenovirus of Serotype 7 to Desmoglein-2.
1. Viruses - published September 2, 2020
2. Hograindleur MA, Effantin G, Fenel D, Mas C, Lieber A, Schoehn G, Fender P, Vassal-Stermann E
Adaptation of Arginine Synthesis among Uropathogenic Branches of the Escherichia coli Phylogeny Reveals Adjustment to the Urinary Tract Habitat.
1. mBio - published September 2, 2020
2. Hibbing ME, Dodson KW, Kalas V, Chen SL, Hultgren SJ
Coronavirus hemagglutinin-esterase and spike proteins coevolve for functional balance and optimal virion avidity.
1. Proc Natl Acad Sci U S A - published September 2, 2020
2. Lang Y, Li W, Li Z, Koerhuis D, van den Burg ACS, Rozemuller E, Bosch BJ, van Kuppeveld FJM, Boons GJ, Huizinga EG, van der Schaar HM, de Groot RJ
Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors.
1. Cell Chem Biol - published September 2, 2020
2. Bushman JW, Donovan KA, Schauer NJ, Liu X, Hu W, Varca AC, Buhrlage SJ, Fischer ES
How Reversible Are the Effects of Fumed Silica on Macrophages? A Proteomics-Informed View.
1. Nanomaterials (Basel) - published September 2, 2020
2. Torres A, Dalzon B, Collin-Faure V, Diemer H, Fenel D, Schoehn G, Cianférani S, Carrière M, Rabilloud T
Ligand Incorporation into Protein Microcrystals for MicroED by On-Grid Soaking.
1. Structure - published September 2, 2020
2. Martynowycz MW, Gonen T
Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.
1. Mol Cell - published September 2, 2020
2. Gao Y, Eskici G, Ramachandran S, Poitevin F, Seven AB, Panova O, Skiniotis G, Cerione RA
Dual antagonists of α5β1/ αvβ1 integrin for airway hyperresponsiveness.
1. Bioorg Med Chem Lett - published September 2, 2020
2. Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H
Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses.
1. Immunity - published September 2, 2020
2. Wong R, Belk JA, Govero J, Uhrlaub JL, Reinartz D, Zhao H, Errico JM, D'Souza L, Ripperger TJ, Nikolich-Zugich J, Shlomchik MJ, Satpathy AT, Fremont DH, Diamond MS, Bhattacharya D
Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area.
1. medRxiv - published September 2, 2020
2. Long SW, Olsen RJ, Christensen PA, Bernard DW, Davis JJ, Shukla M, Nguyen M, Saavedra MO, Yerramilli P, Pruitt L, Subedi S, Kuo HC, Hendrickson H, Eskandari G, Nguyen HAT, Long JH, Kumaraswami M, Goike J, Boutz D, Gollihar J, McLellan JS, Chou CW, Javanmardi K, Finkelstein IJ, Musser JM
Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures.
1. IUCrJ - published September 2, 2020
2. Melero R, Sorzano COS, Foster B, Vilas JL, Martínez M, Marabini R, Ramírez-Aportela E, Sanchez-Garcia R, Herreros D, Del Caño L, Losana P, Fonseca-Reyna YC, Conesa P, Wrapp D, Chacon P, McLellan JS, Tagare HD, Carazo JM
Inappropriate Citation of Vaccine Article.
1. J Infect Dis - published September 1, 2020
2. Reif DM, Chanock SJ, Edwards KM, Crowe JE
Regulated redirection of central carbon flux enhances anaerobic production of bioproducts in Zymomonas mobilis.
1. Metab Eng - published September 1, 2020
2. Liu Y, Ghosh IN, Martien J, Zhang Y, Amador-Noguez D, Landick R
RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells.
1. Nat Genet - published September 1, 2020
2. Long Y, Hwang T, Gooding AR, Goodrich KJ, Rinn JL, Cech TR
X-ray structure of chromium(III)-containing transferrin: First structure of a physiological Cr(III)-binding protein.
1. J Inorg Biochem - published September 1, 2020
2. Petersen CM, Edwards KC, Gilbert NC, Vincent JB, Thompson MK
Structure of the Human Respiratory Syncytial Virus M2-1 Protein in Complex with a Short Positive-Sense Gene-End RNA.
1. Structure - published September 1, 2020
2. Gao Y, Cao D, Pawnikar S, John KP, Ahn HM, Hill S, Ha JM, Parikh P, Ogilvie C, Swain A, Yang A, Bell A, Salazar A, Miao Y, Liang B
Intramuscular Delivery of Replicon RNA Encoding ZIKV-117 Human Monoclonal Antibody Protects against Zika Virus Infection.
1. Mol Ther Methods Clin Dev - published September 1, 2020
2. Erasmus JH, Archer J, Fuerte-Stone J, Khandhar AP, Voigt E, Granger B, Bombardi RG, Govero J, Tan Q, Durnell LA, Coler RN, Diamond MS, Crowe JE Jr, Reed SG, Thackray LB, Carnahan RH, Van Hoeven N
EGFR forms ligand-independent oligomers that are distinct from the active state.
1. J Biol Chem - published September 1, 2020
2. Byrne PO, Hristova K, Leahy DJ
Opening the HIV envelope: potential of CD4 mimics as multifunctional HIV entry inhibitors.
1. Curr Opin HIV AIDS - published September 1, 2020
2. Laumaea A, Smith AB 3rd, Sodroski J, Finzi A
XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells.
1. NAR Cancer - published September 1, 2020
2. Eckelmann BJ, Bacolla A, Wang H, Ye Z, Guerrero EN, Jiang W, El-Zein R, Hegde ML, Tomkinson AE, Tainer JA, Mitra S
Intravitreal methotrexate and fluocinolone acetonide implantation for Vogt-Koyanagi-Harada uveitis.
1. Am J Ophthalmol Case Rep - published September 1, 2020
2. Park JG, Callaway NF, Ludwig CA, Mahajan VB
Peroxynitrous acid (ONOOH) modifies the structure of anastellin and influences its capacity to polymerize fibronectin.
1. Redox Biol - published September 1, 2020
2. He J, Becares ER, Thulstrup PW, Gamon LF, Pedersen JN, Otzen D, Gourdon P, Davies MJ, Hägglund P
The structure-based reaction mechanism of urease, a nickel dependent enzyme: tale of a long debate.
1. J Biol Inorg Chem - published September 1, 2020
2. Mazzei L, Musiani F, Ciurli S
Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection.
1. Virology - published September 1, 2020
2. Goodwin ML, Webster HS, Wang HY, Jenks JA, Nelson CS, Tu JJ, Mangold JF, Valencia S, Pollara J, Edwards W, McLellan JS, Wrapp D, Fu TM, Zhang N, Freed DC, Wang D, An Z, Permar SR
Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing.
1. Nat Hum Behav - published September 1, 2020
2. Allen WE, Altae-Tran H, Briggs J, Jin X, McGee G, Shi A, Raghavan R, Kamariza M, Nova N, Pereta A, Danford C, Kamel A, Gothe P, Milam E, Aurambault J, Primke T, Li W, Inkenbrandt J, Huynh T, Chen E, Lee C, Croatto M, Bentley H, Lu W, Murray R, Travassos M, Coull BA, Openshaw J, Greene CS, Shalem O, King G, Probasco R, Cheng DR, Silbermann B, Zhang F, Lin X
Computational design of transmembrane pores.
1. Nature - published September 1, 2020
2. Xu C, Lu P, Gamal El-Din TM, Pei XY, Johnson MC, Uyeda A, Bick MJ, Xu Q, Jiang D, Bai H, Reggiano G, Hsia Y, Brunette TJ, Dou J, Ma D, Lynch EM, Boyken SE, Huang PS, Stewart L, DiMaio F, Kollman JM, Luisi BF, Matsuura T, Catterall WA, Baker D
Expanded DNA and RNA Trinucleotide Repeats in Myotonic Dystrophy Type 1 Select Their Own Multitarget, Sequence-Selective Inhibitors.
1. Biochemistry - published September 1, 2020
2. Hagler LD, Luu LM, Tonelli M, Lee J, Hayes SM, Bonson SE, Vergara JI, Butcher SE, Zimmerman SC
International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium.
1. NPJ Digit Med - published September 1, 2020
2. Brat GA, Weber GM, Gehlenborg N, Avillach P, Palmer NP, Chiovato L, Cimino J, Waitman LR, Omenn GS, Malovini A, Moore JH, Beaulieu-Jones BK, Tibollo V, Murphy SN, Yi SL, Keller MS, Bellazzi R, Hanauer DA, Serret-Larmande A, Gutierrez-Sacristan A, Holmes JJ, Bell DS, Mandl KD, Follett RW, Klann JG, Murad DA, Scudeller L, Bucalo M, Kirchoff K, Craig J, Obeid J, Jouhet V, Griffier R, Cossin S, Moal B, Patel LP, Bellasi A, Prokosch HU, Kraska D, Sliz P, Tan ALM, Ngiam KY, Zambelli A, Mowery DL, Schiver E, Devkota B, Bradford RL, Daniar M, Daniel C, Benoit V, Bey R, Paris N, Serre P, Orlova N, Dubiel J, Hilka M, Jannot AS, Breant S, Leblanc J, Griffon N, Burgun A, Bernaux M, Sandrin A, Salamanca E, Cormont S, Ganslandt T, Gradinger T, Champ J, Boeker M, Martel P, Esteve L, Gramfort A, Grisel O, Leprovost D, Moreau T, Varoquaux G, Vie JJ, Wassermann D, Mensch A, Caucheteux C, Haverkamp C, Lemaitre G, Bosari S, Krantz ID, South A, Cai T, Kohane IS
Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of Staphylococcus aureus.
1. ACS Infect Dis - published September 1, 2020
2. Fellner M, Lentz CS, Jamieson SA, Brewster JL, Chen L, Bogyo M, Mace PD
Limited Tryptic Digestion-Isotope Dilution Mass Spectrometry (LTD-IDMS): A Reagent-Free Analytical Assay To Quantify Hemagglutinin of A(H5N1) Vaccine Material.
1. Anal Chem - published September 1, 2020
2. Cooper HC, Xie Y, Palladino G, Barr JR, Settembre EC, Wen Y, Williams TL
Inhibitors of BRAF dimers using an allosteric site.
1. Nat Commun - published September 1, 2020
2. Cotto-Rios XM, Agianian B, Gitego N, Zacharioudakis E, Giricz O, Wu Y, Zou Y, Verma A, Poulikakos PI, Gavathiotis E
Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation.
1. Cell Rep - published September 1, 2020
2. Cheung CS, Fruehwirth A, Paparoditis PCG, Shen CH, Foglierini M, Joyce MG, Leung K, Piccoli L, Rawi R, Silacci-Fregni C, Tsybovsky Y, Verardi R, Wang L, Wang S, Yang ES, Zhang B, Zhang Y, Chuang GY, Corti D, Mascola JR, Shapiro L, Kwong PD, Lanzavecchia A, Zhou T
Crystal structure of the Escherichia coli transcription termination factor Rho.
1. Acta Crystallogr F Struct Biol Commun - published September 1, 2020
2. Fan C, Rees DC
Shared structural mechanisms of general anaesthetics and benzodiazepines.
1. Nature - published September 1, 2020
2. Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh RM Jr, Lindahl E, Hibbs RE
Structure based virtual screening identifies small molecule effectors for the sialoglycan binding protein Hsa.
1. Biochem J - published September 1, 2020
2. Agarwal R, Bensing BA, Mi D, Vinson P, Baudry J, Iverson TM, Smith JC
Real-time monitoring of single ZTP riboswitches reveals a complex and kinetically controlled decision landscape.
1. Nat Commun - published September 1, 2020
2. Hua B, Jones CP, Mitra J, Murray PJ, Rosenthal R, Ferré-D'Amaré AR, Ha T
General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM.
1. Proc Natl Acad Sci U S A - published September 1, 2020
2. Wang F, Liu Y, Yu Z, Li S, Feng S, Cheng Y, Agard DA
Structural basis of αE-catenin-F-actin catch bond behavior.
1. Elife - published September 1, 2020
2. Xu XP, Pokutta S, Torres M, Swift MF, Hanein D, Volkmann N, Weis WI
Allosteric coupling between α-rings of the 20S proteasome.
1. Nat Commun - published September 1, 2020
2. Yu Z, Yu Y, Wang F, Myasnikov AG, Coffino P, Cheng Y
Unimodular Methylation by Adenylation-Thiolation Domains Containing an Embedded Methyltransferase.
1. J Mol Biol - published September 1, 2020
2. Mori S, Garneau-Tsodikova S, Tsodikov OV
CHESPA/CHESCA-SPARKY: automated NMR data analysis plugins for SPARKY to map protein allostery.
1. Bioinformatics - published September 1, 2020
2. Shao H, Boulton S, Olivieri C, Mohamed H, Akimoto M, Subrahmanian MV, Veglia G, Markley JL, Melacini G, Lee W
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.
1. Nat Cell Biol - published September 1, 2020
2. Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, Nie L, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JL, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B, Tainer JA, Hung MC
Gender effects in the association between airway microbiome and asthma.
1. Ann Allergy Asthma Immunol - published September 1, 2020
2. Chen R, Wang L, Koch T, Curtis V, Yin-DeClue H, Handley SA, Shan L, Holtzman MJ, Castro M, Wang L
The Ig-like domain of Punctin/MADD-4 is the primary determinant for interaction with the ectodomain of neuroligin NLG-1.
1. J Biol Chem - published September 1, 2020
2. Platsaki S, Zhou X, Pinan-Lucarré B, Delauzun V, Tu H, Mansuelle P, Fourquet P, Bourne Y, Bessereau JL, Marchot P
SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease.
1. Emerg Microbes Infect - published September 1, 2020
2. Wang P, Liu L, Nair MS, Yin MT, Luo Y, Wang Q, Yuan T, Mori K, Solis AG, Yamashita M, Garg A, Purpura LJ, Laracy JC, Yu J, Joshua-Tor L, Sodroski J, Huang Y, Ho DD
Open science, communal culture, and women's participation in the movement to improve science.
1. Proc Natl Acad Sci U S A - published September 1, 2020
2. Murphy MC, Mejia AF, Mejia J, Yan X, Cheryan S, Dasgupta N, Destin M, Fryberg SA, Garcia JA, Haines EL, Harackiewicz JM, Ledgerwood A, Moss-Racusin CA, Park LE, Perry SP, Ratliff KA, Rattan A, Sanchez DT, Savani K, Sekaquaptewa D, Smith JL, Taylor VJ, Thoman DB, Wout DA, Mabry PL, Ressl S, Diekman AB, Pestilli F
Oncoprotein-specific molecular interaction maps (SigMaps) for cancer network analyses.
1. Nat Biotechnol - published September 1, 2020
2. Broyde J, Simpson DR, Murray D, Paull EO, Chu BW, Tagore S, Jones SJ, Griffin AT, Giorgi FM, Lachmann A, Jackson P, Sweet-Cordero EA, Honig B, Califano A
Structure activity studies of truncated latrunculin analogues with anti-malarial activity.
1. ChemMedChem - published September 1, 2020
2. Varghese S, Rahmani R, Drew DR, Beeson JG, Baum J, Smith BJ, Baell J
BAK core dimers bind lipids and can be bridged by them.
1. Nat Struct Mol Biol - published September 1, 2020
2. Cowan AD, Smith NA, Sandow JJ, Kapp EA, Rustam YH, Murphy JM, Brouwer JM, Bernardini JP, Roy MJ, Wardak AZ, Tan IK, Webb AI, Gulbis JM, Smith BJ, Reid GE, Dewson G, Colman PM, Czabotar PE
SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients.
1. bioRxiv - published September 1, 2020
2. Pérez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Ramadoss GN, Silva AC, Flanigan WR, Li H, Nakamura K, Whitman JD, Ott M, Conklin BR, McDevitt TC
SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike.
1. bioRxiv - published September 1, 2020
2. Guthmiller JJ, Stovicek O, Wang J, Changrob S, Li L, Halfmann P, Zheng NY, Utset H, Stamper CT, Dugan HL, Miller WD, Huang M, Dai YN, Nelson CA, Hall PD, Jansen M, Shanmugarajah K, Donington JS, Krammer F, Fremont DH, Joachimiak A, Kawaoka Y, Tesic V, Madariaga ML, Wilson PC
Heterozygous TLR3 Mutation in Patients with Hantavirus Encephalitis.
1. J Clin Immunol - published September 1, 2020
2. Partanen T, Chen J, Lehtonen J, Kuismin O, Rusanen H, Vapalahti O, Vaheri A, Anttila VJ, Bode M, Hautala N, Vuorinen T, Glumoff V, Kraatari M, Åström P, Saarela J, Kauma H, Lorenzo L, Casanova JL, Zhang SY, Seppänen M, Hautala T
Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase.
1. Structure - published September 1, 2020
2. Cohen SE, Brignole EJ, Wittenborn EC, Can M, Thompson S, Ragsdale SW, Drennan CL
New developments in RiPP discovery, enzymology and engineering.
1. Nat Prod Rep - published September 1, 2020
2. Montalbán-López M, Scott TA, Ramesh S, Rahman IR, van Heel AJ, Viel JH, Bandarian V, Dittmann E, Genilloud O, Goto Y, Grande Burgos MJ, Hill C, Kim S, Koehnke J, Latham JA, Link AJ, Martínez B, Nair SK, Nicolet Y, Rebuffat S, Sahl HG, Sareen D, Schmidt EW, Schmitt L, Severinov K, Süssmuth RD, Truman AW, Wang H, Weng JK, van Wezel GP, Zhang Q, Zhong J, Piel J, Mitchell DA, Kuipers OP, van der Donk WA
IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation.
1. Elife - published September 1, 2020
2. Pan L, Lemieux ME, Thomas T, Rogers JM, Lipper CH, Lee W, Johnson C, Sholl LM, South AP, Marto JA, Adelmant GO, Blacklow SC, Aster JC
Oncolytic HSV Vectors and Anti-Tumor Immunity.
1. Curr Issues Mol Biol - published September 1, 2020
2. Glorioso JC, Cohen JB, Goins WF, Hall B, Jackson JW, Kohanbash G, Amankulor N, Kaur B, Caligiuri MA, Chiocca EA, Holland EC, Quéva C
Gold Standard for macromolecular crystallography diffraction data.
1. IUCrJ - published September 1, 2020
2. Bernstein HJ, Förster A, Bhowmick A, Brewster AS, Brockhauser S, Gelisio L, Hall DR, Leonarski F, Mariani V, Santoni G, Vonrhein C, Winter G
MicroED in natural product and small molecule research.
1. Nat Prod Rep - published September 1, 2020
2. Danelius E, Halaby S, van der Donk WA, Gonen T
The ESCRTs - converging on mechanism.
1. J Cell Sci - published September 1, 2020
2. Remec Pavlin M, Hurley JH
Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans.
1. Nat Commun - published September 1, 2020
2. Hurdiss DL, Drulyte I, Lang Y, Shamorkina TM, Pronker MF, van Kuppeveld FJM, Snijder J, de Groot RJ
For Wnt Signaling, Fucosylation of LRP6 Is a Bitter Pill.
1. Cell Chem Biol - published September 1, 2020
2. Shami Shah A, Sun H, Baskin JM
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT_2A Serotonin Receptor.
1. Cell - published September 1, 2020
2. Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
1. Science - published September 1, 2020
2. Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H
A novel DNA primase-helicase pair encoded by SCCmec elements.
1. Elife - published September 1, 2020
2. Bebel A, Walsh MA, Mir-Sanchis I, Rice PA
Winding Down: Selectively Drugging a Promiscuous Pocket in Cryptochrome Slows Circadian Rhythms.
1. Cell Chem Biol - published September 1, 2020
2. Crane BR
An Investigation of Three-Finger Toxin-nAChR Interactions through Rosetta Protein Docking.
1. Toxins (Basel) - published September 1, 2020
2. Gulsevin A, Meiler J
Ultrasensitive high-resolution profiling of early seroconversion in patients with COVID-19.
1. Nat Biomed Eng - published September 1, 2020
2. Norman M, Gilboa T, Ogata AF, Maley AM, Cohen L, Busch EL, Lazarovits R, Mao CP, Cai Y, Zhang J, Feldman JE, Hauser BM, Caradonna TM, Chen B, Schmidt AG, Alter G, Charles RC, Ryan ET, Walt DR
Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface.
1. Neuron - published September 1, 2020
2. Shipley FB, Dani N, Xu H, Deister C, Cui J, Head JP, Sadegh C, Fame RM, Shannon ML, Flores VI, Kishkovich T, Jang E, Klein EM, Goldey GJ, He K, Zhang Y, Holtzman MJ, Kirchhausen T, Wyart C, Moore CI, Andermann ML, Lehtinen MK
Biomimetic nuclear lamin fibers with remarkable toughness and stiffness.
1. Int J Biol Macromol - published September 1, 2020
2. Khayat M, Deri S, Wolf D, Trigano T, Medalia O, Ben-Harush K
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
1. Cell - published September 1, 2020
2. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD
Open conformation of tetraspanins shapes interaction partner networks on cell membranes.
1. EMBO J - published September 1, 2020
2. Yang Y, Liu XR, Greenberg ZJ, Zhou F, He P, Fan L, Liu S, Shen G, Egawa T, Gross ML, Schuettpelz LG, Li W
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
1. Cell - published September 1, 2020
2. Yurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina NV, Shen K, Luban J
Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis.
1. Sci Adv - published September 1, 2020
2. Popgeorgiev N, Sa JD, Jabbour L, Banjara S, Nguyen TTM, Akhavan-E-Sabet A, Gadet R, Ralchev N, Manon S, Hinds MG, Osigus HJ, Schierwater B, Humbert PO, Rimokh R, Gillet G, Kvansakul M
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair.
1. DNA Repair (Amst) - published September 1, 2020
2. Tsutakawa SE, Tsai CL, Yan C, Bralić A, Chazin WJ, Hamdan SM, Schärer OD, Ivanov I, Tainer JA
A Computational Analysis of the Factors Governing the Dynamics of α7 nAChR and Its Homologs.
1. Biophys J - published September 1, 2020
2. Gulsevin A, Meiler J, Horenstein NA
Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of BAF complexes.
1. Nat Cancer - published September 1, 2020
2. Wang Z, Chen K, Jia Y, Chuang JC, Sun X, Lin YH, Celen C, Li L, Huang F, Liu X, Castrillon DH, Wang T, Zhu H