Member Publications

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110 Member Publications for December 2019

In Vitro Reconstitution Assays of Microtubule Amplification and Lattice Repair by the Microtubule-Severing Enzymes Katanin and Spastin.
1. Methods Mol Biol - published December 28, 2019
2. Vemu A, Szczesna E, Roll-Mecak A
In Vitro Microtubule Dynamics Assays Using Dark-Field Microscopy.
1. Methods Mol Biol - published December 28, 2019
2. Spector JO, Vemu A, Roll-Mecak A
Labeling surface proteins with high specificity: Intrinsic limitations of phosphopantetheinyl transferase systems.
1. PLoS One - published December 20, 2019
2. Stüber JC, Plückthun A
An intrinsically disordered proteins community for ELIXIR.
1. F1000Res - published December 12, 2019
2. Davey NE, Babu MM, Blackledge M, Bridge A, Capella-Gutierrez S, Dosztanyi Z, Drysdale R, Edwards RJ, Elofsson A, Felli IC, Gibson TJ, Gutmanas A, Hancock JM, Harrow J, Higgins D, Jeffries CM, Le Mercier P, Mészáros B, Necci M, Notredame C, Orchard S, Ouzounis CA, Pancsa R, Papaleo E, Pierattelli R, Piovesan D, Promponas VJ, Ruch P, Rustici G, Romero P, Sarntivijai S, Saunders G, Schuler B, Sharan M, Shields DC, Sussman JL, Tedds JA, Tompa P, Turewicz M, Vondrasek J, Vranken WF, Wallace BA, Wichapong K, Tosatto SCE
Molecular structures of the human Slo1 K+ channel in complex with β4.
1. Elife - published December 9, 2019
2. Tao X, MacKinnon R
Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalis.
1. Proc Natl Acad Sci U S A - published December 9, 2019
2. Khan A, Davlieva M, Panesso D, Rincon S, Miller WR, Diaz L, Reyes J, Cruz MR, Pemberton O, Nguyen AH, Siegel SD, Planet PJ, Narechania A, Latorre M, Rios R, Singh KV, Ton-That H, Garsin DA, Tran TT, Shamoo Y, Arias CA
A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases.
1. Nature - published December 9, 2019
2. Mendoza SD, Nieweglowska ES, Govindarajan S, Leon LM, Berry JD, Tiwari A, Chaikeeratisak V, Pogliano J, Agard DA, Bondy-Denomy J
Regulation of cGAS- and RLR-mediated immunity to nucleic acids.
1. Nat Immunol - published December 9, 2019
2. Ablasser A, Hur S
Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum.
1. Nat Commun - published December 9, 2019
2. Bortnov V, Tonelli M, Lee W, Lin Z, Annis DS, Demerdash ON, Bateman A, Mitchell JC, Ge Y, Markley JL, Mosher DF
PreDSLpmo: a neural network-based prediction tool for functional annotation of lytic polysaccharide monooxygenases.
1. J Biotechnol - published December 9, 2019
2. Srivastava PA, Hegg EL, Fox BG, Yennamalli RM
Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation.
1. J Am Chem Soc - published December 6, 2019
2. Dick M, Sarai NS, Martynowycz MW, Gonen T, Arnold FH
Structures of the AMPA receptor in complex with its auxiliary subunit cornichon.
1. Science - published December 6, 2019
2. Nakagawa T
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.
1. Science - published December 6, 2019
2. Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Inferring reaction network structure from single-cell, multiplex data, using toric systems theory.
1. PLoS Comput Biol - published December 6, 2019
2. Wang S, Lin JR, Sontag ED, Sorger PK
Unravelling Receptor and RGD Motif Dependence of Retargeted Adenoviral Vectors using Advanced Tumor Model Systems.
1. Sci Rep - published December 6, 2019
2. Chernyavska M, Schmid M, Freitag PC, Palacio-Castañeda V, Piruska A, Huck WTS, Plückthun A, Verdurmen WPR
TBK1 is a Synthetic Lethal Target in Cancer with VHL Loss.
1. Cancer Discov - published December 6, 2019
2. Hu L, Xie H, Liu X, Potjewyd F, James LI, Wilkerson EM, Herring LE, Xie L, Chen X, Cabrera JC, Hong K, Liao C, Tan X, Baldwin AS, Gong K, Zhang Q
Evidence for a Catalytic Strategy to Promote Nucleophile Activation in Metal-Dependent RNA-Cleaving Ribozymes and 8-17 DNAzyme.
1. ACS Catal - published December 6, 2019
2. Ganguly A, Weissman BP, Piccirilli JA, York DM
Programmable Inhibition and Detection of RNA Viruses Using Cas13.
1. Mol Cell - published December 5, 2019
2. Freije CA, Myhrvold C, Boehm CK, Lin AE, Welch NL, Carter A, Metsky HC, Luo CY, Abudayyeh OO, Gootenberg JS, Yozwiak NL, Zhang F, Sabeti PC
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
1. J Med Chem - published December 5, 2019
2. Macdonald JD, Chacón Simon S, Han C, Wang F, Shaw JG, Howes JE, Sai J, Yuh JP, Camper D, Alicie BM, Alvarado J, Nikhar S, Payne W, Aho ER, Bauer JA, Zhao B, Phan J, Thomas LR, Rossanese OW, Tansey WP, Waterson AG, Stauffer SR, Fesik SW
Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds.
1. Elife - published December 5, 2019
2. Manatschal C, Pujol-Giménez J, Poirier M, Reymond JL, Hediger MA, Dutzler R
On crucial roles of two hydrated Mg2+ ions in reaction catalysis of the pistol ribozyme.
1. Angew Chem Int Ed Engl - published December 5, 2019
2. Teplova M, Falschlunger C, Krasheninina O, Egger M, Ren A, Patel DJ, Micura R
Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
1. Nat Commun - published December 5, 2019
2. Park SH, Ayoub A, Lee YT, Xu J, Kim H, Zheng W, Zhang B, Sha L, An S, Zhang Y, Cianfrocco MA, Su M, Dou Y, Cho US
Production of MR1 Tetramers Loaded with Microbial Ligands.
1. Methods Mol Biol - published December 4, 2019
2. Ladd NA, Froyd CA, Adams EJ
Binding of HasA by its transmembrane receptor HasR follows a conformational funnel mechanism.
1. Eur Biophys J - published December 4, 2019
2. Exner TE, Becker S, Becker S, Boniface-Guiraud A, Delepelaire P, Diederichs K, Welte W
Immune repertoire fingerprinting by principal component analysis reveals shared features in subject groups with common exposures.
1. BMC Bioinformatics - published December 4, 2019
2. Sevy AM, Soto C, Bombardi RG, Meiler J, Crowe JE Jr
Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis.
1. Proc Natl Acad Sci U S A - published December 4, 2019
2. Dasgupta M, Budday D, de Oliveira SHP, Madzelan P, Marchany-Rivera D, Seravalli J, Hayes B, Sierra RG, Boutet S, Hunter MS, Alonso-Mori R, Batyuk A, Wierman J, Lyubimov A, Brewster AS, Sauter NK, Applegate GA, Tiwari VK, Berkowitz DB, Thompson MC, Cohen AE, Fraser JS, Wall ME, van den Bedem H, Wilson MA
Multiomic Fermentation Using Chemically Defined Synthetic Hydrolyzates Revealed Multiple Effects of Lignocellulose-Derived Inhibitors on Cell Physiology and Xylose Utilization in Zymomonas mobilis.
1. Front Microbiol - published December 3, 2019
2. Zhang Y, Vera JM, Xie D, Serate J, Pohlmann E, Russell JD, Hebert AS, Coon JJ, Sato TK, Landick R
A Conserved Regulatory Circuit Controls Large Adhesins in Vibrio cholerae.
1. MBio - published December 3, 2019
2. Kitts G, Giglio KM, Zamorano-Sánchez D, Park JH, Townsley L, Cooley RB, Wucher BR, Klose KE, Nadell CD, Yildiz FH, Sondermann H
Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1.
1. J Med Chem - published December 3, 2019
2. Maben Z, Arya R, Rane D, An WF, Metkar S, Hickey M, Bender S, Ali A, Nguyen TT, Evnouchidou I, Schilling R, Stratikos E, Golden J, Stern LJ
The structure of the endogenous ESX-3 secretion system.
1. Elife - published December 3, 2019
2. Poweleit N, Czudnochowski N, Nakagawa R, Trinidad D, Murphy KC, Sassetti CM, Rosenberg OS
Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement.
1. Elife - published December 3, 2019
2. Patel AB, Moore CM, Greber BJ, Luo J, Zukin SA, Ranish J, Nogales E
Publisher Correction: Green Synthesis of Substituted Anilines and Quinazolines from Isatoic Anhydride-8-amide.
1. Sci Rep - published December 3, 2019
2. Gondi SR, Bera AK, Westover KD
A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase.
1. J Biol Chem - published December 3, 2019
2. Scarneo SA, Hughes PF, Yang KW, Carlson DA, Gurbani D, Westover KD, Haystead TAJ
Processing and integration of functionally oriented prespacers in the E. coli CRISPR system depends on bacterial host exonucleases.
1. J Biol Chem - published December 3, 2019
2. Ramachandran A, Summerville L, Learn BA, DeBell L, Bailey S
A Solvent-Exposed Cysteine Forms a Peculiar Ni^II -Binding Site in the Metallochaperone CooT from Rhodospirillum rubrum.
1. Chemistry - published December 2, 2019
2. Alfano M, Veronesi G, Musiani F, Zambelli B, Signor L, Proux O, Rovezzi M, Ciurli S, Cavazza C
cfr(B), cfr(C), and a New cfr-Like Gene, cfr(E), in Clostridium difficile Strains Recovered across Latin America.
1. Antimicrob Agents Chemother - published December 2, 2019
2. Stojković V, Ulate MF, Hidalgo-Villeda F, Aguilar E, Monge-Cascante C, Pizarro-Guajardo M, Tsai K, Tzoc E, Camorlinga M, Paredes-Sabja D, Quesada-Gómez C, Fujimori DG, Rodríguez C
Identification of new antiviral agents against Kaposi's sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation.
1. PLoS Pathog - published December 2, 2019
2. Chen J, Dai L, Goldstein A, Zhang H, Tang W, Forrest JC, Post SR, Chen X, Qin Z
Role of the I16-D194 ionic interaction in the trypsin fold.
1. Sci Rep - published December 2, 2019
2. Stojanovski BM, Chen Z, Koester SK, Pelc LA, Di Cera E
Molecular and structural insights into an asymmetric proteolytic complex (ClpP1P2) from Mycobacterium smegmatis.
1. Sci Rep - published December 2, 2019
2. Nagpal J, Paxman JJ, Zammit JE, Alhuwaider A, Truscott KN, Heras B, Dougan DA
General structural features that regulate integrin affinity revealed by atypical αVβ8.
1. Nat Commun - published December 2, 2019
2. Wang J, Su Y, Iacob RE, Engen JR, Springer TA
Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody.
1. Nat Struct Mol Biol - published December 2, 2019
2. Yang Z, Wang H, Liu AZ, Gristick HB, Bjorkman PJ
High-resolution imaging reveals microbial biofilms on patient urinary catheters despite antibiotic administration.
1. World J Urol - published December 2, 2019
2. Walker JN, Flores-Mireles AL, Lynch AJL, Pinkner C, Caparon MG, Hultgren SJ, Desai A
Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.
1. Cell Syst - published December 2, 2019
2. Chopra SS, Jenney A, Palmer A, Niepel M, Chung M, Mills C, Sivakumaren SC, Liu Q, Chen JY, Yapp C, Asara JM, Gray NS, Sorger PK
Nonspecific Binding of RNA to PARP1 and PARP2 Does Not Lead to Catalytic Activation.
1. Biochemistry - published December 2, 2019
2. Nakamoto MY, Rudolph J, Wuttke DS, Luger K
Structural insight into IAPP-derived amyloid inhibitors and their mechanism of action.
1. Angew Chem Int Ed Engl - published December 2, 2019
2. Niu Z, Prade E, Malideli E, Hille K, Jussupow A, Mideksa Y, Yan LM, Qian C, Fleisch M, Messias AC, Sarkar R, Sattler M, Lamb DC, Feige MJ, Camilloni C, Kapurniotu A, Reif B
A mitochondrial megachannel resides in monomeric F₁F_O ATP synthase.
1. Nat Commun - published December 2, 2019
2. Mnatsakanyan N, Llaguno MC, Yang Y, Yan Y, Weber J, Sigworth FJ, Jonas EA
A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability.
1. Nucleic Acids Res - published December 2, 2019
2. Shi W, Ye HQ, Deng CL, Li R, Zhang B, Gong P
Misannotations of the Genes Encoding Sugar N-formyltransferases.
1. Protein Sci - published December 2, 2019
2. Girardi NM, Thoden JB, Holden HM
Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.
1. Elife - published December 2, 2019
2. Hill S, Reichermeier K, Scott DC, Samentar L, Coulombe-Huntington J, Izzi L, Tang X, Ibarra R, Bertomeu T, Moradian A, Sweredoski MJ, Caberoy N, Schulman BA, Sicheri F, Tyers M, Kleiger G
Trans-endocytosis of intact IL-15Rα-IL-15 complex from presenting cells into NK cells favors signaling for proliferation.
1. Proc Natl Acad Sci U S A - published December 2, 2019
2. Anton OM, Peterson ME, Hollander MJ, Dorward DW, Arora G, Traba J, Rajagopalan S, Snapp EL, Garcia KC, Waldmann TA, Long EO
High-Throughput Generation of Bispecific Binding Proteins by Sortase A-Mediated Coupling for Direct Functional Screening in Cell Culture.
1. Mol Cancer Ther - published December 2, 2019
2. Andres F, Schwill M, Boersma YL, Plückthun A
Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.
1. Cell Rep - published December 2, 2019
2. Wu H, Li L, Chen KM, Homolka D, Gos P, Fleury-Olela F, McCarthy AA, Pillai RS
An atomistic understanding of allosteric inhibition of glutamate racemase: a dampening of native activation dynamics.
1. ChemMedChem - published December 2, 2019
2. Spies MA, Witkin KR, Vance NR, Caldwell C, Li Q, Yu L
Estrogen receptor coregulator binding modulator (ERX-11) enhances the activity of CDK4/6 inhibitors against estrogen receptor-positive breast cancers.
1. Breast Cancer Res - published December 2, 2019
2. Viswanadhapalli S, Ma S, Sareddy GR, Lee TK, Li M, Gilbreath C, Liu X, Luo Y, Pratap UP, Zhou M, Blatt EB, Kassees K, Arteaga C, Alluri P, Rao M, Weintraub ST, Tekmal RR, Ahn JM, Raj GV, Vadlamudi RK
Combining Chalcones with Donepezil to Inhibit Both Cholinesterases and Aβ Fibril Assembly.
1. Molecules - published December 2, 2019
2. Thamban Chandrika N, Fosso MY, Tsodikov OV, LeVine Iii H, Garneau-Tsodikova S
Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS.
1. Elife - published December 2, 2019
2. Reddy B, Bavi N, Lu A, Park Y, Perozo E
Substrate selectivity by the exonuclease Rrp6p.
1. Proc Natl Acad Sci U S A - published December 2, 2019
2. Axhemi A, Wasmuth EV, Lima CD, Jankowsky E
Crystal structure of the N-terminal domain of the trypanosome flagellar protein BILBO1 reveals a ubiquitin fold with a long structured loop for protein binding.
1. J Biol Chem - published December 2, 2019
2. Vidilaseris K, Landrein N, Pivovarova Y, Lesigang J, Aeksiri N, Robinson DR, Bonhivers M, Dong G
Transmembrane helix 6b links proton- and metal-release pathways and drives conformational change in an Nramp-family transition metal transporter.
1. J Biol Chem - published December 2, 2019
2. Bozzi AT, McCabe AL, Barnett BC, Gaudet R
Inhibition of Haspin kinase promotes cell-intrinsic and extrinsic anti-tumor activity.
1. Cancer Res - published December 2, 2019
2. Melms JC, Vallabhaneni S, Mills CE, Yapp C, Chen JY, Morelli E, Waszyk P, Kumar S, Deming D, Moret N, Rodriguez S, Subramanian K, Rogava M, Cartwright ANR, Luoma A, Mei S, Brinker TJ, Miller DM, Spektor A, Schadendorf D, Riggi N, Wucherpfennig KW, Sorger PK, Izar B
Exploring Targeted Degradation Strategy for Oncogenic KRASG12C.
1. Cell Chem Biol - published December 2, 2019
2. Zeng M, Xiong Y, Safaee N, Nowak RP, Donovan KA, Yuan CJ, Nabet B, Gero TW, Feru F, Li L, Gondi S, Ombelets LJ, Quan C, Jänne PA, Kostic M, Scott DA, Westover KD, Fischer ES, Gray NS
Production, Crystallization, and Structure Determination of the IKK-binding Domain of NEMO.
1. J Vis Exp - published December 2, 2019
2. Barczewski AH, Ragusa MJ, Mierke DF, Pellegrini M
Galactosaminogalactan (GAG) and its multiple roles in Aspergillus pathogenesis.
1. Virulence - published December 1, 2019
2. Speth C, Rambach G, Lass-Flörl C, Howell PL, Sheppard DC
Why recombinant antibodies - benefits and applications.
1. Curr Opin Biotechnol - published December 1, 2019
2. Basu K, Green EM, Cheng Y, Craik CS
Influence of substrates and inhibitors on the structure of Klebsiella pneumoniae carbapenemase-2.
1. Exp Biol Med (Maywood) - published December 1, 2019
2. Shurina BA, Page RC
The crystal structure of Capicua HMG-box domain complexed with the ETV5-DNA and its implications for Capicua-mediated cancers.
1. FEBS J - published December 1, 2019
2. Lee H, Song JJ
The dystroglycan receptor maintains glioma stem cells in the vascular niche.
1. Acta Neuropathol - published December 1, 2019
2. Day BW, Lathia JD, Bruce ZC, D'Souza RCJ, Baumgartner U, Ensbey KS, Lim YC, Stringer BW, Akgül S, Offenhäuser C, Li Y, Jamieson PR, Smith FM, Jurd CLR, Robertson T, Inglis PL, Lwin Z, Jeffree RL, Johns TG, Bhat KPL, Rich JN, Campbell KP, Boyd AW
Recent advances in understanding bacterial and archaeoeukaryotic primases.
1. Curr Opin Struct Biol - published December 1, 2019
2. Bergsch J, Allain FH, Lipps G
cGAS and CD-NTase enzymes: structure, mechanism, and evolution.
1. Curr Opin Struct Biol - published December 1, 2019
2. Kranzusch PJ
Structural basis of a small molecule targeting RNA for a specific splicing correction.
1. Nat Chem Biol - published December 1, 2019
2. Campagne S, Boigner S, Rüdisser S, Moursy A, Gillioz L, Knörlein A, Hall J, Ratni H, Cléry A, Allain FH
Prolonged half-life of small-sized therapeutic protein using serum albumin-specific protein binder.
1. J Control Release - published December 1, 2019
2. Kim TY, Park JH, Shim HE, Choi DS, Lee DE, Song JJ, Kim HS
Flexible Binding of m6A Reader Protein YTHDC1 to Its Preferred RNA Motif.
1. J Chem Theory Comput - published December 1, 2019
2. Li Y, Bedi RK, Wiedmer L, Huang D, Śledź P, Caflisch A
ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5.
1. Nat Chem Biol - published December 1, 2019
2. Cao Y, Qiu T, Kathayat RS, Azizi SA, Thorne AK, Ahn D, Fukata Y, Fukata M, Rice PA, Dickinson BC
In vivo structure of the Legionella type II secretion system by electron cryotomography.
1. Nat Microbiol - published December 1, 2019
2. Ghosal D, Kim KW, Zheng H, Kaplan M, Truchan HK, Lopez AE, McIntire IE, Vogel JP, Cianciotto NP, Jensen GJ
Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies.
1. Cell Host Microbe - published December 1, 2019
2. Zhu X, Turner HL, Lang S, McBride R, Bangaru S, Gilchuk IM, Yu W, Paulson JC, Crowe JE Jr, Ward AB, Wilson IA
Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation.
1. ACS Chem Biol - published December 1, 2019
2. Koirala D, Lewicka A, Koldobskaya Y, Huang H, Piccirilli JA
General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases.
1. Chem Commun (Camb) - published December 1, 2019
2. Zhang Z, Cepeda AJ, Robles ML, Hirsch M, Kumru K, Zhou JA, Keatinge-Clay AT
Synthesis of Chiral Spin-Labeled Amino Acids.
1. Org Lett - published December 1, 2019
2. Vuong W, Mosquera-Guagua F, Sanichar R, McDonald TR, Ernst OP, Wang L, Vederas JC
Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice.
1. Eur Heart J - published December 1, 2019
2. Liu CL, Ren J, Wang Y, Zhang X, Sukhova GK, Liao M, Santos M, Luo S, Yang D, Xia M, Inouye K, Hotamisligil GS, Lu G, Upchurch GR, Libby P, Guo J, Zhang J, Shi GP
The structure of the Thermococcus gammatolerans McrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs.
1. J Biol Chem - published December 1, 2019
2. Hosford CJ, Bui AQ, Chappie JS
Clinical and Biochemical Phenotypes in a Family with ENPP1 Mutations.
1. J Bone Miner Res - published December 1, 2019
2. Kotwal A, Ferrer A, Kumar R, Singh RJ, Murthy V, Schultz-Rogers L, Zimmermann M, Lanpher B, Zimmerman K, Stabach PR, Klee E, Braddock DT, Wermers RA
Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism.
1. Cell Host Microbe - published December 1, 2019
2. Binning JM, Chesarino NM, Emerman M, Gross JD
Mapping of a Novel H3-Specific Broadly Neutralizing Monoclonal Antibody Targeting the Hemagglutinin Globular Head Isolated from an Elite Influenza Virus-Immunized Donor Exhibiting Serological Breadth.
1. J Virol - published December 1, 2019
2. Qiu Y, Stegalkina S, Zhang J, Boudanova E, Park A, Zhou Y, Prabakaran P, Pougatcheva S, Ustyugova IV, Vogel TU, Mundle ST, Oomen R, Delagrave S, Ross TM, Kleanthous H, Qiu H
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
1. Nat Commun - published December 1, 2019
2. Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, Nagel ZD, Ellenberger T, Kim IK, Jones DE, Ahmed Z, Tainer JA
Tensin1 expression and function in chronic obstructive pulmonary disease.
1. Sci Rep - published December 1, 2019
2. Stylianou P, Clark K, Gooptu B, Smallwood D, Brightling CE, Amrani Y, Roach KM, Bradding P
Structural basis for the evolution of cyclic phosphodiesterase activity in the U6 snRNA exoribonuclease Usb1.
1. Nucleic Acids Res - published December 1, 2019
2. Nomura Y, Montemayor EJ, Virta JM, Hayes SM, Butcher SE
Compound heterozygous novel frameshift variants in the PROM1 gene result in Leber congenital amaurosis.
1. Cold Spring Harb Mol Case Stud - published December 1, 2019
2. Ragi SD, Lima de Carvalho JR Jr, Tanaka AJ, Park KS, Mahajan VB, Maumenee IH, Tsang SH
The Chromosome-based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis.
1. Mol Plant - published December 1, 2019
2. Liu J, Shi C, Shi CC, Li W, Zhang QJ, Zhang Y, Li K, Lu HF, Shi C, Zhu ST, Xiao ZY, Nan H, Yue Y, Zhu XG, Wu Y, Hong XN, Fan GY, Tong Y, Zhang D, Mao CL, Liu YL, Hao SJ, Liu WQ, Lv MQ, Zhang HB, Liu Y, Hu-Tang GR, Wang JP, Wang JH, Sun YH, Ni SB, Chen WB, Zhang XC, Jiao YN, Eichler EE, Li GH, Liu X, Gao LZ
E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation.
1. Elife - published December 1, 2019
2. Chen J, Gopalkrishnan S, Chiu C, Chen AY, Campbell EA, Gourse RL, Ross W, Darst SA
In-silico Design of Peptide Inhibitors of K-Ras Target in Cancer Disease.
1. J Biomol Struct Dyn - published December 1, 2019
2. Ghufran M, Rehman AU, Shah M, Ayaz M, Ng HL, Wadood A
Publisher Correction: Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody.
1. Nat Struct Mol Biol - published December 1, 2019
2. Yang Z, Wang H, Liu AZ, Gristick HB, Bjorkman PJ
SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis.
1. Proc Natl Acad Sci U S A - published December 1, 2019
2. Greene KS, Lukey MJ, Wang X, Blank B, Druso JE, Lin MJ, Stalnecker CA, Zhang C, Negrón Abril Y, Erickson JW, Wilson KF, Lin H, Weiss RS, Cerione RA
Affinity maturation in a human humoral response to influenza hemagglutinin.
1. Proc Natl Acad Sci U S A - published December 1, 2019
2. McCarthy KR, Raymond DD, Do KT, Schmidt AG, Harrison SC
The structure of the periplasmic FlaG-FlaF complex and its essential role for archaellar swimming motility.
1. Nat Microbiol - published December 1, 2019
2. Tsai CL, Tripp P, Sivabalasarma S, Zhang C, Rodriguez-Franco M, Wipfler RL, Chaudhury P, Banerjee A, Beeby M, Whitaker RJ, Tainer JA, Albers SV
Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing.
1. Proc Natl Acad Sci U S A - published December 1, 2019
2. Heng JS, Hackett SF, Stein-O'Brien GL, Winer BL, Williams J, Goff LA, Nathans J
RIG-I Recognition of RNA Targets: The Influence of Terminal Base Pair Sequence and Overhangs on Affinity and Signaling.
1. Cell Rep - published December 1, 2019
2. Ren X, Linehan MM, Iwasaki A, Pyle AM
RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.
1. Cell Rep - published December 1, 2019
2. Ngo TD, Partin AC, Nam Y
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.
1. Acta Neuropathol - published December 1, 2019
2. Corbett GT, Wang Z, Hong W, Colom-Cadena M, Rose J, Liao M, Asfaw A, Hall TC, Ding L, DeSousa A, Frosch MP, Collinge J, Harris DA, Perkinton MS, Spires-Jones TL, Young-Pearse TL, Billinton A, Walsh DM
Uncut but Primed for Change.
1. CRISPR J - published December 1, 2019
2. Jínek M
Novel mutations in the 3-box motif of the BACK domain of KLHL7 associated with nonsyndromic autosomal dominant retinitis pigmentosa.
1. Orphanet J Rare Dis - published December 1, 2019
2. Oh JK, Lima de Carvalho JR Jr, Sun YJ, Ragi S, Yang J, Levi SR, Ryu J, Bassuk AG, Mahajan VB, Tsang SH
Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling.
1. Cell Chem Biol - published December 1, 2019
2. You I, Erickson EC, Donovan KA, Eleuteri NA, Fischer ES, Gray NS, Toker A
Engineered bacteriophages as programmable biocontrol agents.
1. Curr Opin Biotechnol - published December 1, 2019
2. Huss P, Raman S
Integrative Structural Biology of Protein-RNA Complexes.
1. Structure - published December 1, 2019
2. Dimitrova-Paternoga L, Jagtap PKA, Chen PC, Hennig J
Structure of the Cardiac Sodium Channel.
1. Cell - published December 1, 2019
2. Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Amino and PEG-Amino Graphene Oxide Grids Enrich and Protect Samples for High-resolution Single Particle Cryo-electron Microscopy.
1. J Struct Biol - published December 1, 2019
2. Wang F, Yu Z, Betegon M, Campbell MG, Aksel T, Zhao J, Li S, Douglas SM, Cheng Y, Agard DA
Structural Basis of Human KCNQ1 Modulation and Gating.
1. Cell - published December 1, 2019
2. Sun J, MacKinnon R
Mechanistic Insights into Chemoresistance Mediated by Oncogenic Viruses in Lymphomas.
1. Viruses - published December 1, 2019
2. Chen J, Kendrick S, Qin Z
Rapid Simulation of Unprocessed DEER Decay Data for Protein Fold Prediction.
1. Biophys J - published December 1, 2019
2. Del Alamo D, Tessmer MH, Stein RA, Feix JB, Mchaourab HS, Meiler J
Defining and expanding the phenotype of QARS-associated developmental epileptic encephalopathy.
1. Neurol Genet - published December 1, 2019
2. Johannesen KM, Mitter D, Janowski R, Roth C, Toulouse J, Poulat AL, Ville DM, Chatron N, Brilstra E, Geleijns K, Born AP, McLean S, Nugent K, Baynam G, Poulton C, Dreyer L, Gration D, Schulz S, Dieckmann A, Helbig KL, Merkenschlager A, Jamra R, Finck A, Gardella E, Hjalgrim H, Mirzaa G, Brancati F, Bierhals T, Denecke J, Hempel M, Lemke JR, Rubboli G, Muschke P, Guerrini R, Vetro A, Niessing D, Lesca G, Møller RS
Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations.
1. ACS Pharmacol Transl Sci - published December 1, 2019
2. Li J, Fukase Y, Shang Y, Zou W, Muñoz-Félix JM, Buitrago L, van Agthoven J, Zhang Y, Hara R, Tanaka Y, Okamoto R, Yasui T, Nakahata T, Imaeda T, Aso K, Zhou Y, Locuson C, Nesic D, Duggan M, Takagi J, Vaughan RD, Walz T, Hodivala-Dilke K, Teitelbaum SL, Arnaout MA, Filizola M, Foley MA, Coller BS