Member Publications

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110 Member Publications for October 2019

cAb-Rep: A Database of Curated Antibody Repertoires for Exploring Antibody Diversity and Predicting Antibody Prevalence.
1. Front Immunol - published October 26, 2019
2. Guo Y, Chen K, Kwong PD, Shapiro L, Sheng Z
Naturally Acquired Antibody Response to Malaria Transmission Blocking Vaccine Candidate Pvs230 Domain 1.
1. Front Immunol - published October 23, 2019
2. Tentokam BCN, Amaratunga C, Alani NAH, MacDonald NJ, Narum DL, Salinas ND, Kwan JL, Suon S, Sreng S, Pereira DB, Tolia NH, Fujiwara RT, Bueno LL, Duffy PE, Coelho CH
MARTINI-Based Protein-DNA Coarse-Grained HADDOCKing.
1. Front Mol Biosci - published October 22, 2019
2. Honorato RV, Roel-Touris J, Bonvin AMJJ
Structural Insight of Gasdermin Family Driving Pyroptotic Cell Death.
1. Adv Exp Med Biol - published October 20, 2019
2. Ruan J
Expression, Purification, and Crystallization of Full-Length HSV-1 gB for Structure Determination.
1. Methods Mol Biol - published October 17, 2019
2. Cooper RS, Heldwein EE
Expression, Purification, and Crystallization of HSV-1 Glycoproteins for Structure Determination.
1. Methods Mol Biol - published October 17, 2019
2. White EM, Stampfer SD, Heldwein EE
The Neurospora RNA polymerase II kinase CTK negatively regulates Catalase expression in a chromatin context dependent manner.
1. Environ Microbiol - published October 9, 2019
2. Duan J, Liu Q, Su S, Cha J, Zhou Y, Tang R, Liu X, Wang Y, Liu Y, He Q
The Urfold: Structural Similarity Just above the Superfold Level?
1. Protein Sci - published October 9, 2019
2. Mura C, Veretnik S, Bourne PE
Treatment patterns and outcomes in goblet cell carcinoid tumors of the appendix.
1. J Surg Oncol - published October 8, 2019
2. Fields AC, Lu P, Enzinger A, Goldberg J, Irani J, Bleday R, Nash G, Melnitchouk N
Small angle X-ray scattering-assisted protein structure prediction in CASP13 and emergence of solution structure differences.
1. Proteins - published October 7, 2019
2. Hura GL, Hodge CD, Rosenberg D, Guzenko D, Duarte JM, Monastyrskyy B, Grudinin S, Kryshtafovych A, Tainer JA, Fidelis K, Tsutakawa SE
An ensemble of flexible conformations underlies mechanotransduction by the cadherin-catenin adhesion complex.
1. Proc Natl Acad Sci U S A - published October 7, 2019
2. Bush M, Alhanshali BM, Qian S, Stanley CB, Heller WT, Matsui T, Weiss TM, Nicholl ID, Walz T, Callaway DJE, Bu Z
Structural pathway for allosteric activation of the autophagic PI 3-kinase complex I.
1. Proc Natl Acad Sci U S A - published October 7, 2019
2. Young LN, Goerdeler F, Hurley JH
Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases.
1. Proc Natl Acad Sci U S A - published October 7, 2019
2. Amatya N, Wales TE, Kwon A, Yeung W, Joseph RE, Fulton DB, Kannan N, Engen JR, Andreotti AH
Publisher Correction: Ca2+-regulated Ca2+ channels with an RCK gating ring control plant symbiotic associations.
1. Nat Commun - published October 7, 2019
2. Kim S, Zeng W, Bernard S, Liao J, Venkateshwaran M, Ane JM, Jiang Y
High-resolution cryo-EM structures of TFIIH and their functional implications.
1. Curr Opin Struct Biol - published October 7, 2019
2. Nogales E, Greber BJ
Identification of an adhesive interface for the non-clustered δ1 protocadherin-1 involved in respiratory diseases.
1. Commun Biol - published October 5, 2019
2. Modak D, Sotomayor M
ADAM proteases: Emerging role and targeting of the non-catalytic domains.
1. Cancer Lett - published October 5, 2019
2. Saha N, Robev D, Himanen JP, Nikolov DB
Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.
1. Structure - published October 5, 2019
2. Das S, Malaby AW, Nawrotek A, Zhang W, Zeghouf M, Maslen S, Skehel M, Chakravarthy S, Irving TC, Bilsel O, Cherfils J, Lambright DG
Potent Neutralization of Staphylococcal Enterotoxin B In Vivo by Antibodies that Block Binding to the T-Cell Receptor.
1. J Mol Biol - published October 4, 2019
2. Chen G, Karauzum H, Long H, Carranza D, Holtsberg FW, Howell KA, Abaandou L, Zhang B, Jarvik N, Ye W, Liao GC, Gross ML, Leung DW, Amarasinghe GK, Aman MJ, Sidhu SS
Mucosal Immunization with a pH-Responsive Nanoparticle Vaccine Induces Protective CD8+ Lung-Resident Memory T Cells.
1. ACS Nano - published October 4, 2019
2. Knight FC, Gilchuk P, Kumar A, Becker KW, Sevimli S, Jacobson ME, Suryadevara N, Wang-Bishop L, Boyd KL, Crowe JE Jr, Joyce S, Wilson JT
Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity.
1. Nat Commun - published October 4, 2019
2. Kim G, Azmi L, Jang S, Jung T, Hebert H, Roe AJ, Byron O, Song JJ
Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases.
1. Science - published October 4, 2019
2. Kondo Y, Ognjenović J, Banerjee S, Karandur D, Merk A, Kulhanek K, Wong K, Roose JP, Subramaniam S, Kuriyan J
Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
1. Nature - published October 3, 2019
2. Park E, Rawson S, Li K, Kim BW, Ficarro SB, Pino GG, Sharif H, Marto JA, Jeon H, Eck MJ
Green Synthesis of Substituted Anilines and Quinazolines from Isatoic Anhydride-8-amide.
1. Sci Rep - published October 3, 2019
2. Gondi SR, Bera AK, Westover KD
ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion.
1. Biochem Soc Trans - published October 3, 2019
2. Zein AA, Kaur R, Hussein TOK, Graf GA, Lee JY
New views into class B GPCRs from the crystal structure of PTH1R.
1. FEBS J - published October 3, 2019
2. Ehrenmann J, Schöppe J, Klenk C, Plückthun A
Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II.
1. Genes (Basel) - published October 3, 2019
2. Lee JH, Berger JM
Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
1. Science - published October 3, 2019
2. Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R
Ethanol Impairs NRF2/Antioxidant and Growth Signaling in the Intact Placenta In Vivo and in Human Trophoblasts.
1. Biomolecules - published October 3, 2019
2. Shanmugam S, Patel D, Wolpert JM, Keshvani C, Liu X, Bergeson SE, Kidambi S, Mahimainathan L, Henderson GI, Narasimhan M
Soyuretox, an Intrinsically Disordered Polypeptide Derived from Soybean (Glycine Max) Ubiquitous Urease with Potential Use as a Biopesticide.
1. Int J Mol Sci - published October 3, 2019
2. Kappaun K, Martinelli AHS, Broll V, Zambelli B, Lopes FC, Ligabue-Braun R, Fruttero LL, Moyetta NR, Bonan CD, Carlini CR, Ciurli S
A new chemotype with promise against Trypanosoma cruzi.
1. Bioorg Med Chem Lett - published October 3, 2019
2. Wang X, Cal M, Kaiser M, Buckner FS, Lepesheva GI, Sanford AG, Wallick AI, Davis PH, Vennerstrom JL
CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations.
1. Am J Hum Genet - published October 3, 2019
2. Mann N, Kause F, Henze EK, Gharpure A, Shril S, Connaughton DM, Nakayama M, Klämbt V, Majmundar AJ, Wu CW, Kolvenbach CM, Dai R, Chen J, van der Ven AT, Ityel H, Tooley MJ, Kari JA, Bownass L, El Desoky S, De Franco E, Shalaby M, Tasic V, Bauer SB, Lee RS, Beckel JM, Yu W, Mane SM, Lifton RP, Reutter H, Ellard S, Hibbs RE, Kawate T, Hildebrandt F
Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure.
1. Nat Commun - published October 2, 2019
2. Stone NP, Demo G, Agnello E, Kelch BA
How HIV Nef Proteins Hijack Membrane Traffic to Promote Infection.
1. J Virol - published October 2, 2019
2. Buffalo CZ, Iwamoto Y, Hurley JH, Ren X
Flexibility in nucleic acid binding is central to APOBEC3H antiviral activity.
1. J Virol - published October 2, 2019
2. Bohn JA, DaSilva J, Kharytonchyk S, Mercedes M, Vosters J, Telesnitsky A, Hatziioannou T, Smith JL
Tuning Radical Relay Residues by Proton Management Rescues Protein Electron Hopping.
1. J Am Chem Soc - published October 2, 2019
2. Yee EF, Dzikovski B, Crane BR
FSP1 is a glutathione-independent ferroptosis suppressor.
1. Nature - published October 2, 2019
2. Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Grocin AG, Xavier da Silva TN, Panzilius E, Scheel C, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O'Donnel V, Proneth B, Popowicz GM, Pratt D, Angeli JPF, Conrad M
Binding site plasticity in viral PPxY Late domain recognition by the third WW domain of human NEDD4.
1. Sci Rep - published October 2, 2019
2. Iglesias-Bexiga M, Palencia A, Corbi-Verge C, Martin-Malpartida P, Blanco FJ, Macias MJ, Cobos ES, Luque I
Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.
1. Nat Commun - published October 2, 2019
2. Hellerschmied D, Lehner A, Franicevic N, Arnese R, Johnson C, Vogel A, Meinhart A, Kurzbauer R, Deszcz L, Gazda L, Geeves M, Clausen T
Human VH1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis.
1. MBio - published October 2, 2019
2. Bennett MR, Dong J, Bombardi RG, Soto C, Parrington HM, Nargi RS, Schoeder CT, Nagel MB, Schey KL, Meiler J, Skaar EP, Crowe JE Jr
Characterization of resistance to a potent D-peptide HIV entry inhibitor.
1. Retrovirology - published October 2, 2019
2. Smith AR, Weinstock MT, Siglin AE, Whitby FG, Francis JN, Hill CP, Eckert DM, Root MJ, Kay MS
Synthesis of defined mono-de-N-acetylated β-(1→6)-N-acetyl-d-glucosamine oligosaccharides to characterize PgaB hydrolase activity.
1. Org Biomol Chem - published October 2, 2019
2. Forman A, Pfoh R, Eddenden A, Howell PL, Nitz M
The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer.
1. Cell Rep - published October 2, 2019
2. Cocce KJ, Jasper JS, Desautels TK, Everett L, Wardell S, Westerling T, Baldi R, Wright TM, Tavares K, Yllanes A, Bae Y, Blitzer JT, Logsdon C, Rakiec DP, Ruddy DA, Jiang T, Broadwater G, Hyslop T, Hall A, Laine M, Phung L, Greene GL, Martin LA, Pancholi S, Dowsett M, Detre S, Marks JR, Crawford GE, Brown M, Norris JD, Chang CY, McDonnell DP
Structural analysis of biological targets by host:guest crystal lattice engineering.
1. Sci Rep - published October 2, 2019
2. Ernst P, Plückthun A, Mittl PRE
EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins.
1. Cell Death Differ - published October 2, 2019
2. Fitzsimmons L, Cartlidge R, Chang C, Sejic N, Galbraith LCA, Suraweera CD, Croom-Carter D, Dewson G, Tierney RJ, Bell AI, Shannon-Lowe C, Herold MJ, Rickinson AB, Colman PM, Huang DCS, Strasser A, Kvansakul M, Rowe M, Kelly GL
A Dynamic Variation of Pulmonary ACE2 Is Required To Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice.
1. J Immunol - published October 2, 2019
2. Sodhi CP, Nguyen J, Yamaguchi Y, Werts AD, Lu P, Ladd MR, Fulton WB, Kovler ML, Wang S, Prindle T Jr, Zhang Y, Lazartigues ED, Holtzman MJ, Alcorn JF, Hackam DJ, Jia H
Characterization of Recurrences Following Second Breast-Conserving Surgery with Intraoperative Radiotherapy.
1. Ann Surg Oncol - published October 2, 2019
2. Boehm KM, Chen J, Trichter S, Abdallah H, Zhuo R, Nowak EJ, Ng J, Swistel AJ
MAIT cells are imprinted by the microbiota in early life and promote tissue repair.
1. Science - published October 2, 2019
2. Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y
Structural Insights into the Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII).
1. Cold Spring Harb Perspect Biol - published October 2, 2019
2. Bhattacharyya M, Karandur D, Kuriyan J
Binding partner- and force-promoted changes in αE-catenin conformation probed by native cysteine labeling.
1. Sci Rep - published October 2, 2019
2. Terekhova K, Pokutta S, Kee YS, Li J, Tajkhorshid E, Fuller G, Dunn AR, Weis WI
Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities.
1. Protein Sci - published October 2, 2019
2. Teyra J, Ernst A, Singer A, Sicheri F, Sidhu SS
A novel AKR1C3 specific prodrug TH3424 with potent anti-tumor activity in liver cancer.
1. Clin Pharmacol Ther - published October 2, 2019
2. He P, Wang C, Wang Y, Wang C, Zhou C, Cao D, Li J, Bushnell DA, Li Q, Kornberg RD, Xie W, Wang Z
Mechanisms of virus dissemination in bone marrow of HIV-1-infected humanized BLT mice.
1. Elife - published October 2, 2019
2. Ladinsky MS, Khamaikawin W, Jung Y, Lin S, Lam J, An DS, Bjorkman PJ, Kieffer C
Structure of the P element transpososome reveals new twists on the DD(E/D) theme.
1. Nat Struct Mol Biol - published October 2, 2019
2. Rice PA
Vaccine innovations for emerging infectious diseases-a symposium report.
1. Ann N Y Acad Sci - published October 2, 2019
2. Cable J, Srikantiah P, Crowe JE Jr, Pulendran B, Hill A, Ginsberg A, Koff W, Mathew A, Ng T, Jansen K, Glenn G, Permar S, Wilson I, Weiner DB, Weissman D, Rappuoli R
Structure of a P element transposase-DNA complex reveals unusual DNA structures and GTP-DNA contacts.
1. Nat Struct Mol Biol - published October 2, 2019
2. Ghanim GE, Kellogg EH, Nogales E, Rio DC
Structure of an allosteric modulator bound to the CB1 cannabinoid receptor.
1. Nat Chem Biol - published October 2, 2019
2. Shao Z, Yan W, Chapman K, Ramesh K, Ferrell AJ, Yin J, Wang X, Xu Q, Rosenbaum DM
Alternative chloride transport pathways as pharmacological targets for the treatment of cystic fibrosis.
1. J Cyst Fibros - published October 2, 2019
2. Quesada R, Dutzler R
Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins.
1. Cell Rep - published October 2, 2019
2. Dunne M, Rupf B, Tala M, Qabrati X, Ernst P, Shen Y, Sumrall E, Heeb L, Plückthun A, Loessner MJ, Kilcher S
Structure and redox properties of the diheme electron carrier cytochrome c4 from Pseudomonas aeruginosa.
1. J Inorg Biochem - published October 2, 2019
2. Carpenter JM, Zhong F, Ragusa MJ, Louro RO, Hogan DA, Pletneva EV
Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS.
1. Mol Cell - published October 2, 2019
2. Hsu PL, Shi H, Leonen C, Kang J, Chatterjee C, Zheng N
Function and Dysfunction of TMC Channels in Inner Ear Hair Cells.
1. Cold Spring Harb Perspect Med - published October 1, 2019
2. Corey DP, Akyuz N, Holt JR
MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans.
1. Cell Death Differ - published October 1, 2019
2. Sendoel A, Subasic D, Ducoli L, Keller M, Michel E, Kohler I, Singh KD, Zheng X, Brümmer A, Imig J, Kishore S, Wu Y, Kanitz A, Kaech A, Mittal N, Matia-González AM, Gerber AP, Zavolan M, Aebersold R, Hall J, Allain FH, Hengartner MO
High-Throughput Fluorescence Polarization Assay to Identify Ligands Using Purified G Protein-Coupled Receptor.
1. SLAS Discov - published October 1, 2019
2. Heine P, Witt G, Gilardi A, Gribbon P, Kummer L, Plückthun A
The Innate Immune Protein S100A9 Protects from T-Helper Cell Type 2-mediated Allergic Airway Inflammation.
1. Am J Respir Cell Mol Biol - published October 1, 2019
2. Palmer LD, Maloney KN, Boyd KL, Goleniewska AK, Toki S, Maxwell CN, Chazin WJ, Peebles RS Jr, Newcomb DC, Skaar EP
Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling.
1. Biochim Biophys Acta Mol Cell Biol Lipids - published October 1, 2019
2. Cheng WWL, Budelier MM, Sugasawa Y, Bergdoll L, Queralt-Martín M, Rosencrans W, Rostovtseva TK, Chen ZW, Abramson J, Krishnan K, Covey DF, Whitelegge JP, Evers AS
The big picture of chromatin biology by cryo-EM.
1. Curr Opin Struct Biol - published October 1, 2019
2. Jang S, Song JJ
Structural Basis for Diltiazem Block of a Voltage-Gated Ca2+ Channel.
1. Mol Pharmacol - published October 1, 2019
2. Tang L, Gamal El-Din TM, Lenaeus MJ, Zheng N, Catterall WA
A conserved histidine in Group-1 influenza subtype hemagglutinin proteins is essential for membrane fusion activity.
1. Virology - published October 1, 2019
2. Trost JF, Wang W, Liang B, Galloway SE, Agbogu E, Byrd-Leotis L, Steinhauer DA
Editorial overview: The future after the cryo-EM resolution revolution.
1. Curr Opin Struct Biol - published October 1, 2019
2. Dal Peraro M, Song JJ
Regulation of histone methylation by automethylation of PRC2.
1. Genes Dev - published October 1, 2019
2. Wang X, Long Y, Paucek RD, Gooding AR, Lee T, Burdorf RM, Cech TR
CD23 is a glycan-binding receptor in some mammalian species.
1. J Biol Chem - published October 1, 2019
2. Jégouzo SAF, Feinberg H, Morrison AG, Holder A, May A, Huang Z, Jiang L, Lasanajak Y, Smith DF, Werling D, Drickamer K, Weis WI, Taylor ME
Less Is More: Coarse-Grained Integrative Modeling of Large Biomolecular Assemblies with HADDOCK.
1. J Chem Theory Comput - published October 1, 2019
2. Roel-Touris J, Don CG, V Honorato R, Rodrigues JPGLM, Bonvin AMJJ
SHERLOCK: nucleic acid detection with CRISPR nucleases.
1. Nat Protoc - published October 1, 2019
2. Kellner MJ, Koob JG, Gootenberg JS, Abudayyeh OO, Zhang F
Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor).
1. Arterioscler Thromb Vasc Biol - published October 1, 2019
2. Ben Djoudi Ouadda A, Gauthier MS, Susan-Resiga D, Girard E, Essalmani R, Black M, Marcinkiewicz J, Forget D, Hamelin J, Evagelidis A, Ly K, Day R, Galarneau L, Corbin F, Coulombe B, Çaku A, Tagliabracci VS, Seidah NG
The NSL complex maintains nuclear architecture stability via lamin A/C acetylation.
1. Nat Cell Biol - published October 1, 2019
2. Karoutas A, Szymanski W, Rausch T, Guhathakurta S, Rog-Zielinska EA, Peyronnet R, Seyfferth J, Chen HR, de Leeuw R, Herquel B, Kimura H, Mittler G, Kohl P, Medalia O, Korbel JO, Akhtar A
Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation.
1. Proc Natl Acad Sci U S A - published October 1, 2019
2. Wang X, Piersma SJ, Elliott JI, Errico JM, Gainey MD, Yang L, Nelson CA, Yokoyama WM, Fremont DH
Scribble co-operatively binds multiple α1D-adrenergic receptor C-terminal PDZ ligands.
1. Sci Rep - published October 1, 2019
2. Janezic EM, Harris DA, Dinh D, Lee KS, Stewart A, Hinds TR, Hsu PL, Zheng N, Hague C
Arachidonic Acid Kills Staphylococcus aureus through a Lipid Peroxidation Mechanism.
1. MBio - published October 1, 2019
2. Beavers WN, Monteith AJ, Amarnath V, Mernaugh RL, Roberts LJ 2nd, Chazin WJ, Davies SS, Skaar EP
Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer.
1. Cell Rep - published October 1, 2019
2. Lukey MJ, Cluntun AA, Katt WP, Lin MJ, Druso JE, Ramachandran S, Erickson JW, Le HH, Wang ZE, Blank B, Greene KS, Cerione RA
Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly.
1. Nat Struct Mol Biol - published October 1, 2019
2. Morris KL, Jones JR, Halebian M, Wu S, Baker M, Armache JP, Avila Ibarra A, Sessions RB, Cameron AD, Cheng Y, Smith CJ
Structure of an RNA helix with pyrimidine mismatches and cross-strand stacking.
1. Acta Crystallogr F Struct Biol Commun - published October 1, 2019
2. Montemayor EJ, Virta JM, Hagler LD, Zimmerman SC, Butcher SE
Phosphorylation of Nephrin induces phase separated domains that move through actomyosin contraction.
1. Mol Biol Cell - published October 1, 2019
2. Kim S, Kalappurakkal JM, Mayor S, Rosen MK
Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses.
1. J Exp Med - published October 1, 2019
2. Jiang X, Muthusamy V, Fedorova O, Kong Y, Kim DJ, Bosenberg M, Pyle AM, Iwasaki A
Structure and functional implications of WYL domain-containing bacterial DNA damage response regulator PafBC.
1. Nat Commun - published October 1, 2019
2. Müller AU, Leibundgut M, Ban N, Weber-Ban E
Accurate Prediction for Antibody Resistance of Clinical HIV-1 Isolates.
1. Sci Rep - published October 1, 2019
2. Rawi R, Mall R, Shen CH, Farney SK, Shiakolas A, Zhou J, Bensmail H, Chun TW, Doria-Rose NA, Lynch RM, Mascola JR, Kwong PD, Chuang GY
The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
1. EMBO J - published October 1, 2019
2. Acosta-Reyes F, Neupane R, Frank J, Fernández IS
Reinvestigating the synthesis and efficacy of small benzimidazole derivatives as presequence protease enhancers.
1. Eur J Med Chem - published October 1, 2019
2. Li NS, Liang W, Piccirilli JA, Tang WJ
Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau.
1. Elife - published October 1, 2019
2. Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS
Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination.
1. Nat Immunol - published October 1, 2019
2. Lo WL, Shah NH, Rubin SA, Zhang W, Horkova V, Fallahee IR, Stepanek O, Zon LI, Kuriyan J, Weiss A
KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis.
1. Proc Natl Acad Sci U S A - published October 1, 2019
2. Rabara D, Tran TH, Dharmaiah S, Stephens RM, McCormick F, Simanshu DK, Holderfield M
The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response.
1. Elife - published October 1, 2019
2. Perlaza K, Toutkoushian H, Boone M, Lam M, Iwai M, Jonikas MC, Walter P, Ramundo S
HP1 reshapes nucleosome core to promote heterochromatin phase separation.
1. Nature - published October 1, 2019
2. Sanulli S, Trnka MJ, Dharmarajan V, Tibble RW, Pascal BD, Burlingame AL, Griffin PR, Gross JD, Narlikar GJ
MMOD-induced structural changes of hydroxylase in soluble methane monooxygenase.
1. Sci Adv - published October 1, 2019
2. Kim H, An S, Park YR, Jang H, Yoo H, Park SH, Lee SJ, Cho US
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.
1. J Nat Prod - published October 1, 2019
2. Di Micco S, Masullo M, Bandak AF, Berger JM, Riccio R, Piacente S, Bifulco G
The Staphylococcus aureus ArlRS two-component system regulates virulence factor expression through MgrA.
1. Mol Microbiol - published October 1, 2019
2. Crosby HA, Tiwari N, Kwiecinski JM, Xu Z, Dykstra A, Jenul C, Fuentes EJ, Horswill AR
RNA binding activates RIG-I by releasing an autorepressed signaling domain.
1. Sci Adv - published October 1, 2019
2. Dickey TH, Song B, Pyle AM
Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold.
1. ACS Med Chem Lett - published October 1, 2019
2. Remillard D, Buckley DL, Seo HS, Ferguson FM, Dhe-Paganon S, Bradner JE, Gray NS
Unique structural features in an Nramp metal transporter impart substrate-specific proton cotransport and a kinetic bias to favor import.
1. J Gen Physiol - published October 1, 2019
2. Bozzi AT, Bane LB, Zimanyi CM, Gaudet R
Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy.
1. Proc Natl Acad Sci U S A - published October 1, 2019
2. Zammataro L, Lopez S, Bellone S, Pettinella F, Bonazzoli E, Perrone E, Zhao S, Menderes G, Altwerger G, Han C, Zeybek B, Bianchi A, Manzano A, Manara P, Cocco E, Buza N, Hui P, Wong S, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Angioli R, Raspagliesi F, Scambia G, Choi J, Dong W, Bilguvar K, Alexandrov LB, Silasi DA, Huang GS, Ratner E, Azodi M, Schwartz PE, Pirazzoli V, Stiegler AL, Boggon TJ, Lifton RP, Schlessinger J, Santin AD
Filament-like Assemblies of Intracellular Nucleic Acid Sensors: Commonalities and Differences.
1. Mol Cell - published October 1, 2019
2. Cadena C, Hur S
Coordination of a single calcium ion in the EF-hand maintains the off state of the stromal interaction molecule luminal domain.
1. J Mol Biol - published October 1, 2019
2. Enomoto M, Nishikawa T, Back SI, Ishiyama N, Zheng L, Stathopulos PB, Ikura M
Properties of Stress Granule and P-Body Proteomes.
1. Mol Cell - published October 1, 2019
2. Youn JY, Dyakov BJA, Zhang J, Knight JDR, Vernon RM, Forman-Kay JD, Gingras AC
Computational approaches to therapeutic antibody design: established methods and emerging trends.
1. Brief Bioinform - published October 1, 2019
2. Norman RA, Ambrosetti F, Bonvin AMJJ, Colwell LJ, Kelm S, Kumar S, Krawczyk K
Structural and Functional Analysis of Ubiquitin-based inhibitors that Target the Backsides of E2 Enzymes.
1. J Mol Biol - published October 1, 2019
2. Garg P, Ceccarelli DF, Keszei AF, Kourinov I, Sicheri F, Sidhu SS
Editorial overview: Protein-nucleic acid interactions - cryo-EM, what else?
1. Curr Opin Struct Biol - published October 1, 2019
2. Allain FH, Jinek M
Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold.
1. Sci Adv - published October 1, 2019
2. Cash JN, Urata S, Li S, Ravala SK, Avramova LV, Shost MD, Gutkind JS, Tesmer JJG, Cianfrocco MA
SIBPA on the crest of the Adriatic Sea wave: Introduction to the SIBPA XXIV (2018 congress) special issue.
1. Biophys Chem - published October 1, 2019
2. Giacomazza D, Viappiani C, Di Cera E, Musio C
Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine.
1. Cell Metab - published October 1, 2019
2. Deshmukh AS, Peijs L, Beaudry JL, Jespersen NZ, Nielsen CH, Ma T, Brunner AD, Larsen TJ, Bayarri-Olmos R, Prabhakar BS, Helgstrand C, Severinsen MCK, Holst B, Kjaer A, Tang-Christensen M, Sanfridson A, Garred P, Privé GG, Pedersen BK, Gerhart-Hines Z, Nielsen S, Drucker DJ, Mann M, Scheele C
Single-particle cryo-EM: beyond the resolution.
1. Natl Sci Rev - published October 1, 2019
2. Armache JP, Cheng Y